BMedSc Bachelor of Medical Science Year 2 Curriculum · BMedSc Bachelor of Medical Science Year 2...

BMedSc Bachelor of Medical Science Year 2 Curriculum Please set your programme to show “bookmarks”. By clicking on the bookmarks you can navigate to each separate module in the second year of the course. In addition to a description of the module, you will also find a list of the teaching sessions in the module. This will help you to gain detailed information about the Medical Science course. The modules in the first term are:

Molecular Biology Immunology and Haematology Analytical Methods in Biomedical Science (part 1) Neuroscience 2 Renal and Urinary System Cell Biology

In the second term you will study:

Infection 2 Social Responsibilities in Biomedical Science Cardiovascular and Respiratory Science 2 Endocrine and Reproductive Science Systems Pharmacology Analytical Methods in Biomedical Science (part 2)

Please note that all modules in the first and second years are compulsory. This means that by the end of two years you will have a good breadth and depth of understanding in all of the disciplines of medical science. Therefore, you will have a large choice of options to study in the final year. With this format there is no less choice than on a different course; but, for our course the choice is delayed to a time when you can make an informed decision.

BMedSc Bachelor of Medical Science Year 2 Modules: Molecular Biology

Module Description To review techniques involving recombinant DNA, the study of gene expression and their practical applications in clinical genetics and treatment of diseases. Detailed consideration is given to the theory and practice of studying the genome, gene expression and clinical genetics. Topics also include a review of recombinant DNA techniques and their application in transgenic animal studies, gene therapy and biotechnology. Sessions in this module are closely integrated with those in the Cell Biology module, and provide essential background to all level 3 modules. Module Content

Session Session Title

Lecture Introduction to Molecular Biology

Lecture Hybridisation

Lecture Restriction endonucleases and other enzymes

Tutorial Tutorial 1

Lecture DNA Sequencing

Lecture Southern blotting and related techniques

Lecture The nature and organisation of the Genome

Lecture The Role of RNA

Tutorial Tutorial 2

Lecture Bioinformatics I

Lecture Genes

Lecture Polymerase Chain Reaction

Lecture Bioinformatics II

Lecture Eukaryotic gene expression

Lecture Techniques for studying gene expression

Lecture Structure of genes

Lecture Transcription of protein coding genes

Lecture Sequence specific transcription factors

Lecture The nature of mutations

Lecture Chromosome Disease

Practical Computer Practical

Lecture Evolution

Tutorial Tutorial 3

Practical Lab Practical

Lecture Restriction mapping, linkage and recombination

Lecture Human Genome Project

Lecture Functional Cloning

Lecture Dominant Inheritance, Recessive Inheritance and DR and AR disorders

Lecture Expression of cloned DNA in vitro and in vivo

Lecture Transgenic Animals

Lecture Biotechnology I

Lecture Biotechnology II

Lecture Proteomics

Assessment

Learning Outcomes By the end of this module the student should have an understanding of:

1. The organisation of the human genome 2. The methods of identifying and manipulating gene sequences by cloning and related

techniques 3. Gene structure and expression 4. The use of molecular biology in the identification and characterisation of genes related to

human disease 5. The production of clinically important proteins by recombinant DNA technology 6. Gene therapy 7. Bioinformatics methods and their practical applications 8. Basimolecular evolution principles

Assessment The module is assessed by a combination of a written examination (25 MCQ and 2 essay questions) and course work:

Examination 75% (Semester 2) Course work 25% (Semester 1)

The course work component will include the following:

1 Essay (1000 – 1500 words) 33.3% 1 Practical write-up covering all practical sessions 33.3% 1 MCQ assessment 33.3%

Linked modules Cell Biology.

Hours 48 Hours (28 lectures (scheduled), 4x 3hr practicals (scheduled), 3x 1hr tutorials (scheduled), 1x 3hr CAL (scheduled), 1 MCQ assessment)

BMedSc Bachelor of Medical Science Year 2 Modules: Immunology and Haematology Module Description The module presents a coherent overview of the components of the immune system, their role in the induction of immune responses and as effector mechanisms that resolve infection. Abnormal immune responses are also covered, with reference to human disease. Blood cells are discussed from the viewpoint of the immunologist and the haematologist. The practicals illustrate effector functions mediated by antibodies. The basic science underpinning immune reactivity is emphasized in tutorials and the students are prepared for the practicals that are designed to illustrate principles Module Content


Lecture Introduction to Immunology and Haematology

Tutorial Tutorial 1

Lecture Recognition of pathogens by cells of the innate immune system

Lecture Complement

Tutorial Tutorial 2

Lecture Neutrophils and macrophages in the control of infection

Lecture Recognition of antigens by the adaptive immune system

Lecture Differentiation of cells in the bone marrow

Lecture Antigen processing and presentation

Tutorial Tutorial 3

Lecture T cell differentiation

Practical Practical 1

Tutorial Tutorial 4

Lecture Priming of naive T cells

Tutorial Tutorial 5

Lecture Effector functions of T cells

Lecture B cell differentiation

Tutorial Tutorial 6

Lecture B-T co-operation

Lecture Function of antibodies

Lecture Leukocyte migration

Practical Practical 2

Tutorial Tutorial 7

Lecture Tolerance and autoimmunity

Lecture Immunodeficiency

Tutorial Tutorial 8

Lecture Vaccination

Lecture Allergy, asthma and parasite immunity

Tutorial Tutorial 9

Learning Outcomes At completion of the course students should have an understanding of:

1. The innate and adaptive immune response. 2. Blood cells, their major functions and related diseases. 3. Primary and secondary lymphoid tissues and their role in the generation of both the cellular

and humoral immune repertoire. 4. Self, non-self discrimination. 5. Practical experience of outcomes from antigen-antibody interactions. 6. Abnormal immune responses.




Practical write-up 25%

Linked modules Infection level 2.

Hours 43 Hours. Lectures 18x1h; Tutorials 9x1hr; Practicals 2x8hr Guided independent study. We timetable a tutorial following each set of two lectures.

BMedSc Bachelor of Medical Science Year 2 Modules: Analytical Methods in Biomedical Science

Module Description The two aims of the statistics element of the course are: (1) to equip students with the conceptual understanding of statistics necessary for the interpretation of statistical evidence in the scientific literature and (2) to equip students with the practical skills required to enable them to undertake a basic analysis of data.

The basic principles and practice of experimental approaches are reviewed, together with consideration of how these are used to identify and visualise cellular components and cellular processes. Examples of different techniques along with an introduction to proteomic database analysis, microscopy and digital image processing are provided so as to enhance familiarity with the methodologies and to develop observational and deductive skills. The latter are the focus of cluster sessions in Semester 1 and PBL sessions in semester 2 to provide the foundation for effectively undertaking the final year research project.

Module Content


Statistics Strand

Lecture Introduction to Statistics

Lecture Vetting variability and pursuing population parameters

Lecture Do Smarties make you smarter?

SGT SG1 Overview of Statistics

Lecture The effect of the change in the HE tuition fee structure on subject choice

ComPrac CP1 Summary statistics and graphs

Lecture The stroop test

Lecture The effect of voter turnout on general election results

Lecture The effect of mRNA and protein concentration in Daoy medulloblastoma cells

Lecture The effect of school size on A-level performance

Lecture Can Vitamin D supplements help patients with prostate cancer?

SGT SG2 Statistics test

ComPrac CP2 Statistical tests

Lecture Practice MCQ and feedback

SGT SG3 Presentations

Exam MCQ Test

Analytical Methods – Semester 1

Lecture Biomedical applications of analytical methods

Lecture Biomedical Applications of Radioactivity

ComPrac Receptor Interactions

Lecture Spectroscopic applications in the biomedical sciences

Lecture Experiment design and data analysis

CompPrac Protein Mutations

CompPrac Rescuing cellular malfunction

Lecture Transgenic animal approaches

Lecture Preparation of abstract – self study session

Lecture Research Seminar

Lecture Magentic Resonance (MR) and imaging

CompPrac Proteomic analysis and MCQ

Practical MCQ feedback

Lecture Research methodology overview

Analytical Methods – Semester 2

Lecture Introduction

Lecture Research Methods 1

Lecture Fluorescence Activated Cell Sorting (FACS)

CompPrac FACS – Problem based learning

Lecture Optics & Light microscopy

CompPrac Extra session

Lecture Imaging Processing

SDL Microscopy applications

SGT Research Methods 2

Lecture Image Analysis


Lecture Third Year Projects

Lecture Research Seminar


SGT Journal club 1

SGT Experimental Design 1

SGT Journal club 2

SGT Experimental Design 2

Exam MCQ Assessment

Learning Outcomes By the end of the module the student should be able to:

Learning outcomes for Statistics

1. Recognise the different types of data which arise in the course of laboratory or medical investigations.

2. Select appropriate methods for the presentation of the data in summary form 3. Demonstrate knowledge of methods that are available for the analysis of data, and be able

to select (a) method(s) appropriate to the question(s) asked about a study 4. Demonstrate an understanding of the concepts of statistical significance, confidence

interval, hypothesis test and p-value arising from the statistical analysis of data. 5. Undertake simple statistical analyses using data provided.

6. Write a short report about an investigation of data, including presenting results both descriptively and analytically

Learning outcomes for Analytical Methods Part 1 (Semester 1)

7. Outline the information available from radioactive labelling, chromatography, electrophoresis, immunoassays and immunoblotting, mass spectrometry, absorption spectroscopy and transgenic approaches.

8. State what can be learnt about protein interactions from electrophoretic analysis, surface Plasmon resonance, spectroscopy and crystallography.

9. Outline the role of database scrutiny in proteomics research.

Learning outcomes for Analytical Methods Part 2 (Semester 2)

10. Describe microscopic techniques and imaging procedures relevant to medical science. 11. Demonstrate an understanding of the experimental process, critically evaluate primary

literature, plan experiments and interpret data

Assessment Statistics: MCQ to test basic knowledge (18 questions, 50 minutes). Short individual project using data from a real-life situation (up to 8 pages). Each is weighted 50% of the statistics element. (semester 1) Analytical methods Part 1: MCQ data analysis test (20 questions, 40 minute), 250 word abstract – equally weighted (semester 1) Analytical methods Part 2, MCQ (25 questions, 40 minutes), 2 reports, group submissions (2 sides A4 each, Research Methods report and Mini project proposal describing experimental rationale, methods etc,) all equally weighted (semester 2) Module assessment 33.3% for each of Statistics, Analytical Methods Part 1 and Analytical Methods Part 2 (no end of year examination) Hours 51 Hours (Analytical Methods Part 1 (12 hours): 8 lectures along with 4 computer cluster-based sessions

(one of which is 2 hours to allow for MCQ test) that are based on student participation in experimental design and data analysis. Handouts and reference to web-based learning resources, together with school-based IT instruction are also available. Analytical Methods Part 2 (23 hours): 8 hrs lectures, 5 x 2 hrs seminars to focus on research methods, data analysis and experimental design, 1 hr tutorial, and 4 hrs computer practicals. Stats (16 hours): 11 lectures (one of which is a practice MCQ), 5 SGTs (seminars) based on practicing statistical methods taught in the lectures. Handouts and Excel templates for undertaking various statistical tests are provided. Further formative MCQ tests available on WebCT.

BMedSc Bachelor of Medical Science Year 2 Modules: Neuroscience 2

Module Description This modules builds upon information given in Neuroscience 1 and progresses from a detailed description of the properties and functioning of individual neurones and synapses through to a discussion of the operation of different brain systems and what goes wrong in diseases of the nervous system. The specific issues which are covered include: Cell and molecular biology of neurones and synapses; Pain transmission in the spinal cord; CNS control of motor function including the pathophysiology of motor disorders, such as Parkinson’s Disease; Mechanisms underlying disorders of cortical functioning such as Epilepsy, Depression and Schizophrenia. The therapy for all neurological/psychiatric conditions is described. Module Content


Lecture Membrane Properties

Lecture Ion Channels: Properties 1

Lecture Ion Channels: Properties 2

Lecture Ion Channels: Molecular Structure

Tutorial Ion Channels

Practical Action Potential/Ion Channels

Lecture Synapses: Ionotropic Receptors 1

Lecture Synapses: Ionotropic Receptors 2

Lecture Synapses: Metabotropic Receptors

Lecture Topography of Brain and Spinal Cord

Tutorial Synapses

Lecture Drugs affecting synaptic transmission in the CNS

Practical Basic neuroanatomy of the brain

Lecture Sensory System: Pain

Practical Topography of the Motor Systems

Lecture Motor Systems 1



Lecture Drugs used in movement disorders

Tutorial Motor System

Lecture Higher Cortical Function (Dys)Function: Anxiety

Tutorial Motor System

Practical EMG Practical

Lecture Higher Cortical Function (Dys)Function: Depression

Lecture Higher Cortical Function (Dys)Function: Schizophrenia

Lecture Neuroleptic Drugs

Lecture Drugs of Abuse and Drug Addiction

Tutorial Higher Cortical Function (Dys)Function: Psychiatry

Lecture Higher Cortical Function/Dysfunction: Neural Networks

Lecture Higher Cortical Function/Dysfunction: Epilepsy

Lecture Antiepileptic Drugs

Tutorial Higher Cortical Function (Dys)Function: Neurology

Learning Outcomes By the end of the module the student will be able to:

1. Demonstrate knowledge of the topography of the brain including aspects of its functional organisation.

2. Demonstrate an understanding of the means by which ion channels control the functional characteristics of neurons. Be aware of the methods used to measure channel activity.

3. Demonstrate an understanding of the control of synaptic function by various neurotransmitters and their receptors.

4. Demonstrate a working knowledge of the spinal and higher cortical control of motor function.

5. Demonstrate a working knowledge of the neural mechanisms that underlie pain transmission within the central nervous system

6. Demonstrate an understanding of the pathophysiological mechanisms that underlie various processes and disorders of the central nervous system (expecially pain, epilepsy, schizophrenia, depression and anxiety). Be familiar with the mechanisms of action of the pharmacological agents used for these disorders.




Practical write-up (1; 500 - 1000 words) 15 %

Web-based Assessments (2) 10%

Hours Student: 37 hrs (Lectures: 22 hrs (Scheduled); Tutorials: 9 hrs (Scheduled); Practicals: 6 hrs (Scheduled); Guided independent study: 63 hrs

BMedSc Bachelor of Medical Science Year 2 Modules: Renal and Urinary System

Module Description The anatomy, physiology and toxicology of the kidney and urinary tract and the role of the kidneys in homeostasis of osmolality, volume and acid-base. See links to Pharmacology II and Endocrine and Reproductive Systems Module Content


Lecture Control of fluids by kidneys

Lecture Origin of waste products

Lecture Topography and Histology of the urinary system

Lecture Urine as an indicator of disease

Lecture Glomerular filtration

Practical Histology of kidneys and urinary tract

Lecture Tubular function 1

Lecture Tubular function 2

Lecture Urine concentration and dilution

Lecture The renal blood supply

Tutorial Tutorial

Lecture Osmoregulation

Lecture Body fluid volume regulation

Tutorial Tutorial

Lecture The storage and passage of urine

Lecture Acid-Base Balance

Lecture Shock and Haemorrhage

Lecture Renal failure

Lecture Effects of drugs on kidney and role of kidney in drug excretion

Tutorial Tutorial

Practical Renal function Practical

Practical Urine Testing practical

Tutorial Tutorial/Practical Overview


1. Understand the ultrastructure and topography of the kidneys and the urinary tract and their relation to other organs in the abdomen

2. Understand the special features of the renal blood supply which adapt the organ for filtration and reabsorption, and how blood flow and GFR can be measured

3. Describe the transport properties of the nephron and how these relate to excretory function of the kidneys

4. Understand the role of the kidneys in regulating body fluid osmolarity, volume and acid-base balance; and the methods of investigation used to obtain this knowledge.

Assessment The module is assessed by a combination of written examination (25 MCQ and 2 essay questions) and course work:



Practical write-up with questions 25%

Linked modules Endocrine and Reproductive Science.

Hours 27 Hours (Lectures, practicals, tutorials - 17 x 1hr lectures, 4 x 1hr tutorials, 3 x 3hr practicals.)

BMedSc Bachelor of Medical Science Year 2 Modules: Cell Biology

Module Description The aim of this module is to review fundamental cellular processes, at the molecular level. Attention is focussed on subject areas at the forefront of cell biology today, including; chromatin structure and gene expression, differentiation, cell proliferation and cell death, cell-cell communication, cytoplasmic signalling, proteolysis, intracellular trafficking and the cell biology of cancer. Components of this module will explore the experimental process, both theoretically (in PBL sessions) and in practice (in laboratory practicals), drawing on examples from the subject areas covered by lectures. Coursework also seeks to develop IT, written and oral presentation skills. Sessions in this module are tightly integrated with those in the proposed Molecular Biology module. Module Content


Lecture Introduction to Cell Biology the module

Lecture Organisation of DNA 1

Lecture Organisation of DNA 2

SDL Cell Signalling 1

Lecture Cell Signalling 2

Lecture Chromatin and Gene Expression 1

Lecture Chromatin and Gene Expression 2

Lecture Cell Signalling 3

Tutorial Chromatin and Gene Expression PBL

Tutorial In-course Assessment (briefing)

Lecture Cells in Their Social Context 1

Practical Computer-based Learning session

Lecture Cells in Their Social Context 2

Lecture Control of Cell Numbers 1

Tutorial Cell Signalling: PBL

Lecture Control of Cell Numbers 2

Lecture Targeting Cell Signalling in Cancer Therapy

Tutorial Social Context PBL

Lecture Development 1

Lecture Intracellular Transport 1

Lecture Intracellular Transport 2

Tutorial Control of Cell Numbers: PBL

Lecture Proteolysis in cellular control 1

Lecture Proteolysis in cellular control 2

Practical Cell Biology Practical 1


Practical Cell Biology Practical 2

Lecture Cell Biology of Cancer 1





Tutorial Cell Biology of Cancer: PBL

Student Presentations


1. Demonstrate a knowledge and understanding of the molecular basis of fundamental cellular processes.

2. Understand how cells utilise and control these processes in multi-cellular organisms such as man.

3. Understand how various factors can influence normal cellular processes, resulting in diseases such as cancer.

4. Understand the experimental process and the value of model experimental systems 5. Prepare and deliver a short oral presentation 6. Prepare and present a short essay




1500 word essay 10% 10 minute oral presentation 10% questions based on practical 5%

Linked modules Molecular Biology

Hours 39 Hours (23 hrs lectures; 6 hrs seminars; 4hrs tutorials; 6 hrs practical.)

BMedSc Bachelor of Medical Science Year 2 Modules: Infection 2

Module Description The module extends the main structural features of microorganisms and enables a deeper understanding of molecular microbiology, diagnosis, control by vaccination. See links to Immunology and Haematology Module Content


Lecture Introduction and classification

Lecture Virus nucleic acids

Lecture Virus Assay

Practical Tissue Culture

Practical Virus Assay

Lecture Virus structure and proteins 1

Lecture Diagnosis of viral infections

Lecture Virus structure and proteins 2

Lecture Attachment and penetration

Practical Data analysis

Tutorial Tutorial

LabPrac Virus Assay

Lecture DNA Viruses

Lecture RNA -ve strand viruses

Practical Data analysis

Lecture RNA +ve strand viruses 1

Tutorial RNA +ve strand viruses 2

Lecture Immunity, immunization

Tutorial Tutorial 2

Lecture Antiviral Therapy

Lecture Colonisation of the Host

Lecture Biogenesis of bacterial protein antigens

Lecture Bacterial Toxins

Lecture Regulation of gene expression

Lecture Evasion of the immune system

Lecture Overview of mechanisms of antimicrobial actions and

Lecture Immunoprophylaxis

Practical Basic Procedures I

Lecture Arthropod Borne Infections

Practical Basic Procedures II

Practical Basic Procedures III

Lecture Opportunistic Infections

Lecture Respiratory tract infections

Lecture Gastrointestinal infections

Lecture Urinary Tract Infections

Lecture Invasive bacterial disease

Lecture Sexualy Transmitted Bacterial Disease

Tutorial Tutorial 3


1. Demonstrate detailed understanding of major virus and bacterial families in human disease. 2. Understand the disease process and possible treatments 3. Acquire experience of isolating and characterising micro-organisms. 4. Analyse and interpret experimental work.




Virology practical write-up 22.5% Bacteriology practical write-up 2.5%

Linked modules Immunology and Haematology.

Hours 42 Hours (Bacteriology – 14 x 1hr lectures, 1 x 1hr tutorial, 3 x 2hr practicals. Virology – 13 x 1hr lectures, 2 x 1hr seminars, 3 x 2hr practicals.)

BMedSc Bachelor of Medical Science Year 2 Modules: Social Responsibilities in Biomedical Science

Module Description Module addresses current ethical debates, and includes sessions on how complex technical information should be presented in the public domain

Module Content


Lecture Knowledge Versus Application

Lecture Animal Experimentation and Animal Rights

Lecture Animal Legislation

Lecture Global Warming

Lecture Informing the Public about Science 1

Lecture Informing the Public about Science 2

Lecture Food and Health

Lecture Ethical Issues in Medicine

Lecture Food and the Environment

Lecture Complementary and Alternative Medicine

Learning Outcomes By the end of the module the student will:

1. Be aware of current ethical debates in science and medicine. 2. Be aware of how information is presented to the general public, and how public opinion can

be manipulated by the media 3. Be aware of the difficulties of presenting complex technical information to a naïve audience 4. Understand the legislation which controls animal experimentation, and genetic engineering

in the UK and how this differs from other countries. 5. Understand the history of conflict between science and religion, and the persecution of

scientists who have questioned religious dogma. 6. Recognise the legal dimensions of science and learn to distinguish between legal

judgement and ethical justification 7. Demonstrate skills of ethical argument – eg to be able to identify (at least) 2 sides of a

problem and argue coherently from each. 8. Recognise the importance of explicit reasoning in written and oral communication.

Assessment The module is assessed by coursework only: Course work 100% (Semester 2)

The course work component will include the following: Essay 100%

Hours 28 Hours (Seminars/Discussions 14x 2hr seminars, directed reading).

BMedSc Bachelor of Medical Science Year 2 Modules: Cardiovascular & Respiratory Science

Module Description The module follows on and expands the 1st Year Cardiovascular and Respiratory System Module. The lectures are organised into a series of themes: Haematology; Molecular and Cellular Cardiology; Special Tissue Circulations; Cardiovascular Pathology; Respiration and Integration of Cardiovascular and Respiratory Function. Lectures are integrated with the Level II Pharmacology module. Small Group sessions follow on from, and review the material of, the major themes. Practical sessions are designed to give students hands-on experience of cardiovascular and respiratory investigations in man. Students are given an overview lecture at the start of the course to orientate their learning, are provided with a range of online support material, and are encouraged to more fully engage with the SGTs and practical session by means of prior emails reminding them of the core principles to be explored. Module Content


Lecture Introduction to the Cardiovascular and Respiratory System

Lecture Cardic arrhythmicity

Lecture Cardiac Function: EC coupling

Lecture Cardiac Function: Failing heart

Lecture Physical Characteristics of blood

Lecture Red and White cell circulation

SGT Cardiac Function: Review of Material in Lectures L04-L06

Lecture Atherosclerosis

Lecture coronary circulation

Lecture CNS control of cardiovascular system

Lecture Disturbances of blood pressue and volume

SGT Cardiovascular Pathology - Review of materials in lectures L10-L12

Lecture Cardiovascular Pathology 3: Shock and Haemorrhage

Practical Exercise and Blood pressure regulation

Tutorial Cardiovascular Pathology: Review of material in Lectures L10-L12

Lecture Pulmonary circulation

Lecture review of the respiratory system

Practical Exercise and Blood pressure reg

Lecture Peripheral (chemical) control of respiration

Lecture Normal & abnormal pulmonary function

Lecture Respiratory failure

Lecture Integration of Cardiovascular and Respiratory function

SGT Respiration: Review of materials in lectures L13-L17

Lecture Temperature regulation

Lecture CVRS integration: exercise

Lecture Integration: Alerting response, Vasovagal syncope

Lecture CVRS integration: sleep

Lecture acclimatisation to high Altitude

Practical Pulmonary function in Rest and Exercise

SGT 'Integrative Physiology: review of material in lectures L18-21

SGT Pulmonary function in rest and exercise - review of practical data'

Lecture Interactive Demonstration


1. Appreciate both the cardiovascular and respiratory systems as an integrated unit 2. Expand their understanding of the molecular and cellular basis of normal cardiovascular

and respiratory function. 3. Understand the biochemical, and physiological basis of pathological diseases of the

cardiovascular & respiratory systems. 4. Appreciate the experimental manner in which the different levels are investigated. 5. Use study skills and independent thought processes to discuss and evaluate scientific

material. Assessment The module is assessed by a combination of a written examination (4 short note and 2 essay questions) and course work: (Essays and practical write-ups.)


The course work component includes the following: Practical write-up of typically 1000 words plus data presentation 12.5% One essay of 1500 words 12.5%

Linked modules Systems Pharmacology level 2.

Hours 33 Hours: Lectures (24x1hr); Small Group Teaching (4x1hr); Practicals (1x1hr; 2x2hr).

BMedSc Bachelor of Medical Science Year 2 Modules: Endocrine & Reproductive Science

Module Description This module provides a basic understanding of endocrine and reproductive physiology. Information is delivered on the mechanisms of hormone biosynthesis, transport, interaction with receptors, action and control. Methods of measuring hormone levels and diseases related to endocrine function will be described. Early lectures will outline general features of endocrine physiology and these will be followed by more detailed lectures in which the function of each of the major glands will be dealt with in turn. The function of the reproductive organs will be covered in some detail with emphasis on germ cell production. The processes associated with fertilisation and infertility, embryo and foetal development, pregnancy and parturition, and the important developmental processes occurring during puberty will also discussed. Module Content


Lecture Overview of the Endocrine and Reproductive Module

Lecture Hormone Action

Lecture Clinical Endocrinology

Lecture Hormone Synthesis

Lecture Diagnosis of Endocrine disorders

Tutorial Hormone Action and Synthesis

Lecture Adrenal Cortex 1

Lecture Adrenal Cortex 2/ Arden Medulla

Practical Adrenal Gland CBL

Lecture Hormonal Control of Blood Sugar

Practical Measurement of Hormones

CompPrac

LabPrac Measurement of Hormones 2 – Cotisol

CompPrac Glucose Tolerance Test

Lecture Thyroid

Lecture Regulation of Calcium Metabolism

Lecture Pituitary Gland

Tutorial Understanding Thyroid Function

Lecture Testicular Function

Lecture Ovarian Function

Lecture Fertilisation and Contraception

Tutorial Reproduction 1

Lecture Embryogenesis

Lecture Infertility

Lecture Pregnancy and Parturition

Lecture Puberty



Learning Outcomes By the end of the module the student will have:

1. A basic knowledge of the anatomy of the major endocrine glands. 2. A good knowledge of the synthesis, secretion, physiological action and regulation of each of

the hormones from all of the major endocrine glands. 3. An understanding of methods by which hormones can be measured, diseases which can

arise due to endocrine malfunction, and methods for diagnosis and treatment of such diseases.

4. An understanding of the importance of hormones in homeostasis. 5. An understanding of testicular and ovarian function. 6. A good knowledge of the processes associated with fertilisation and how infertility can

hinder these. 7. A good understanding of the mechanism of action of various contraceptives 8. An understanding of embryonic and foetal development, pregnancy and parturition. 9. A good knowledge of the processes associated with puberty 10. An understanding of analysis, interpretation and presentation of data in a concise, accurate

form.

Assessment The module is assessed by a combination of a written examination (4 short notes and 2 essay questions) and course work:



Abstract 400 words 12.5% Practical write-up 12.5% (Proforma on glucose tolerance test practical will be a formative assessment; 100% of mark for lab practical write up for cortisol measurement test)

Linked modules Renal and Urinary System.

Hours 36 Hours (5 x 1 hr tutorials; 2 x 2 hr and 1 x 3hr computer practical; 1 x 3 hr wet practicals (cortisol

measurement); 19 x 1 hr lectures

BMedSc Bachelor of Medical Science Year 2 Modules: Systems Pharmacology

Module Description This module complements the concurrent modules on the physiology of the cardiovascular, respiratory, renal and endocrine systems and aims to give the students an in depth understanding of the various mechanisms by which drugs may influence the functioning of these systems.

Module Content


Lecture Introduction to the Module

Lecture Diuretics

Lecture Toxic effect of drugs on the kidney

Lecture Drugs used in inflammatory conditions

Lecture Immunosuppressant drugs

Tutorial Tutorial 1

Lecture Drugs and the control of blood clotting

Lecture Drugs, lipids and atherosclerosis

Lecture Thyroid hormones and anti-thy drugs

Lecture Hypoglycaemic drugs

Lecture Cardiac Pharmacology 1

Tutorial Tutorial 2

Lecture Cardiac Pharmacology 2

Tutorial Tutorial 3

Lecture Pharmacological control of vascular tone: neuronal mediators

Lecture Blood borne mediators

Lecture Endothelium derived mediators

Lecture Vasodilator drugs

Tutorial Tutorial 4

Lecture Calcium ion channel pharmacology

Lecture Drugs and the control of blood pressure

Practical Peripheral control of vas tone

Lecture The pharmacology of 5-HT

Lecture Ecosanoid mediators

Tutorial Tutorial 5

Lecture Bronchial hypersensitivity and asthma

Lecture Assessment of Computer practical

Lecture Respiratory stimulants and depressants

Lecture Drug induced de-sensitisation

Tutorial Tutorial 6

Practical Binding Practical

Lecture Binding Practical – Data analysis session


1. Understand the variety of mechanisms by which drugs can influence the functioning of the cardiovascular, respiratory, renal and endocrine systems

2. Know the mechanisms of action and side effects of the main drugs in current use to influence these systems

3. Appreciate how of an in-depth understanding of these systems informs the rational development of new drugs and new treatment strategies

4. Follow a schedule to perform quantitative experiments to determine the effects of drugs and be able to present and interpret the data from these experiments

5. Assemble a logical argument, substantiated by facts. 6. Students will also learn to work as an effective member of a team during practical sessions.

Assessment The module is assessed by a combination of written examination (25 MCQ and 2 essay questions) and course work:



Two practical write-ups 12.5% each

Linked modules Cardiovascular and Respiratory Science (Level 2).

Hours 34 Hours (21 lectures, 6 tutorials, 1 laboratory and 1 computer practical).

BMedSc Bachelor of Medical Science Year 2 Curriculum · BMedSc Bachelor of Medical Science Year 2...

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