Blood and Blood Components Dr. Soheila Zareifar Pediatric Hematology/Oncology Department January 2016 Goals Of Blood Collection Maintain viability and function Maintain viability and function Prevent physical changes Prevent physical changes Minimize bacterial contamination Minimize bacterial contamination Blood safety/ Transfusion safety SAFE TRANSFUSION PROCESS SAFE BLOOD COMPONENT Blood Transfusion -Guidance and Regulations WHO recommendations WHO recommendations safe and adequate blood supply safe and adequate blood supply also clinical transfusion process also clinical transfusion process Appropriate use of blood Collection samples, patient ID compatibility testing Administration of blood Adverse event reporting Hospital transfusion committee Better Blood Transfusion Better Blood Transfusion EU Optimal Blood Use manual EU Optimal Blood Use manual (www.optimalblooduse.eu) (www.optimalblooduse.eu) Council of Europe 47 member countries Infective risks Infective risks National Institutes of Health Management chronic viral hepatitis in thalassemia: recommendations of an international panel Marco et al Blood Hep C antibody in thalassemia patients Ref no. Anti- HCV + % 2006 Iran Turkey Thailand Lebanon India10421 Malaysia Iraq Pakistan3560 Italy Bahrain Brazil Hong Kong UK Wonke B et al Clin Pathol 1990;43: % of 73 patients positive Thompson et al 2011 Brit Journal of Haematol, 153, 121128 Thalassemia Clinical Research Network Investigators: 169 of 697 Hep C Ab pos 24% Cunningham et al 2004 Blood 104, 34 5% patients aged