Fetal hypoxia. Birth asphyxia. Sakharova Inna. Ye., MD, PhD.
Birth asphyxia
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Transcript of Birth asphyxia
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Birth asphyxia
รองศาสตราจารย์ นาย์แพทย์ อต�วุ�ทธ กมุ�ทมุาศ
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Asphyxia
APGAR score at 1 minute < 7 Interruption in oxygen delivery to the fetus
• Hypoxia
• Hypercapnia
Birth asphyxia เป็�นภาวะที่�ที่ารกแรกเก�ดไม่�สาม่ารถป็ร�บตั�วในการเป็ลี่�ยนแป็ลี่งที่างระบบหายใจแลี่ะการไหลี่เวยนเลี่�อดจากครรภ"ม่ารดา ม่าส$�ภาวะแวดลี่%อม่ภายนอก
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Neonatal Evaluation and Resuscitation
APGAR Scoring
A Appearance
P Pulse
G Grimace
A Activity
R Respirations
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APGAR Score
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Apgar Score
Total Score = 10
score 7-10 normal
score 5-6 mild birth asphyxia
score 3-4 moderate birth asphyxia
score 0-2 severe birth asphyxia
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Causes of Neonatal Mortality
Infection32%
Other5%
Congenital Anomalies
10%
Birth Asphyxia29%
Complications of Prematurity
24%
Source: WHO 2001 estimates (based on data collected around 1999)
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Etiology
Birth asphyxia in undeveloped countries 10% of newborns suffer mild to moderate birth
asphyxia 1% of newborns suffer severe birth asphyxia
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Risk factors
Antepartum :Maternal diabetes post-term gestation
Pregnancy induced hypertension multiple gestation
Chronic hypertension size-dates discrepancy
Previous Rh sensitization maternal drug abuse
Previous stillbirth maternal age >35 or<16
Bleeding in second or third trimester no prenatal care
Maternal infection
Polyhydramnios or oligohydramnios
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Risk factors
Intrapartum :Elective or emergency c/s
Precipitous labour, prolonged labour
Prolonged second stage of labour
Premature labour
Abnormal presentation
Rupture of membranes > 24 hours
Foul-smelling amniotic fluid
Non reassuring fetal heart rate patterns
Use of general anesthesia
Prolapsed cord
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Assessment
Fetal heart rate slows Electronic fetal monitoring
• persistent late deceleration of any magnitude
• persistent severe variable deceleration
• prolonged bradycardia
• decreased or absent beat-to-beat variability Thick meconium-stained amniotic fluid Fetal scalp blood analysis show pH less than 7.2
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Effects of Asphyxia
Central nervous system
• infarction, intracranial hemorrhage, cerebral edema, seizure, hypoxic-
ischemic encephalopathy
Cardiovascular
• bradycardia, ventricular hypertrophy, arrhythmia, hypotension, myocardial ischemia
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Effects of Asphyxia
Respiratory system • apnea, respiratory distress syndrome
cyanosis
KUB • acute tubular necrosis, bladder paralysis
Gastrointestinal tract • necrotizing enterocolitis , stress ulcer
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Effects of Asphyxia
Hematology • Disseminated intravascular coagulation
Metabolic • hypoglycemia, hyperglycemia, hypocalcemia, hyponatremia
Integument • subcutaneous fat necrosis
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Neonatal Resuscitation
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Newborn Resuscitation AHA/AAP Guidelines
Meconium -stained amniotic fluid: endotracheal suctioning of the depressed - not the vigorous child
Hyperthermia should be avoided
100% oxygen is still recommended, however if supplemental oxygen is unavailable room air should be used
Chest compression: Initiated if heart rate is absent or remains < 60 bpm despite adequate ventilation for 30 sec
Medications: Epinephrine 0.01-0.03 mg/kg if heart rate < 60 bpm in spite of 30 seconds adequate ventilation and chest compression
Volume: Isotonic crystalloid solution or 0-neg blood
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Prognosis
Apgar score < 5 at 10 minutes : nearly 50 %
death or disability (Leicester) No spontaneous respiration after 20 min : 60
% disability in survivors (USA). No spontaneous respiration after 30 minutes :
nearly 100 % disability in survivors (Newcastle).
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Facts About Newborn ResuscitationThe most important is to get air into the lungs
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Hypoxic-ischemic encephalopathy(HIE)
Hypoxic-ischemic encephalopathy is an important cause of permanent damage to central nervous system cells, which may result in
- neonatal death
- manifest later as cerebral palsy or mental deficiency
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Essential criteria:
1.Metabolic acidosis on cord blood or very early (1 hour) neonatal blood (pH 7.0 or base deficit > 12 mmol/l.)
2.Early onset of severe or moderate neonatal encephalopathy in infants of > 34 weeks gestation.
3.Cerebral palsy of the spastic quadriplegic or
dyskinetic type.
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Criteria that together suggest
A sentinel hypoxic event immediately before or during labour.
A sudden, rapid and sustained deterioration of fetal heart rate.
Apgar scores of 0-6 for longer than 5 minutes. Early evidence of multisystem involvement. Early imaging evidence of acute cerebral
abnormality.