Biotin(vitamin B7)

Maria Elisa Belarso

BSN 2-C

Index•Introduction to Biotin•Line Structure•3D Structure•Biochemical and Metabolic Functions

•Dietary Requirements

•Dietary Sources•Biochemical and Biochemical and Metabolic ReactionsMetabolic Reactions

•Deficiencies and Deficiencies and DisordersDisorders•SummarySummary•Biotin does not Biotin does not initiates muscle pain.initiates muscle pain.•hypotoniahypotonia

Meet Biotin!• Biotin is a member of the B vitamin family.

• Biotin is sulfur containing and water soluble.

• The primary function is a coenzyme in carbohydrate, protein, and lipid metabolism.

• Essential for cell growth and replication of DNA and RNA.

• Biotin is synthesized by bacteria, yeast, and fungi. It is also produced in small amounts in the human large intestine.

Line Structure

3-D Structure

Biochemical and Metabolic Functions• Aids in maintaining blood sugar.

• Metabolizes lipids, proteins, and carbohydrates.

• Maintains hair, nails, skin, and sweat glands.

• Assists with muscle pain.

• Prevents baldness and graying hair.

Dietary Requirements• The daily average intake for adults 19

years and older is 30-100 µg/day.

• Most filipinos consume 28-42 µg/day.

Dietary Sources• Biotin is found in these food sources:

-egg yolk-organ meat-poultry-milk & cheese-whole grains, rice

-salmonBest source of Biotin

Biotin can be found in nuts –almonds,peanuts etc, but those aren’t really useful sources.

However, carrots, bananas & avocados (in smoothies), and papaya are good sources. 

Biochemical and Metabolic Reactions• Egg White Injury: AVIDIN

-Research with rats that were fed egg white protein showed the symptoms of biotin deficiency.-Avidin is a glycoprotein found in egg whites. -Avidin binds very tightly to biotin preventing its absorption. -When egg whites are cooked the avidin is denatured and is digested by proteolytic enzymes.

Biochemical and Metabolic Reactions• Biotin is the coenzyme for 4 carboxylases.

1.Acetyl coenzyme A carboxylase: found in the mitochondria; catalyzes the carboxylation of Acetyl CoA to Malonyl CoA.2.Pyruvate carboxylase: found in the mitochondria; catalyzes the carboxylation of pyruvate to form oxaloacetate.3.Methylcrotonyl-CoA carboxylase: found in the mitochondria; involved in the metabolism of L-leucine.4.Propionyl-CoA carboxylase: involved in the metabolism of L-isoleucine, L-valine, L-threonine, and L-methionine.

Deficiencies and Disorders• Dermatitis• Hair Loss• Neuromuscular dysfunction• Signs & Symptoms:

-scaly skin-rash around eyes, nose, mouth, and ears-hypotonia-depression-lethargy-loss of appetite-high cholesterol

DermatitisSkin inflammation is one of the common

symptoms of biotin deficiency. The common form of dermatitis that is found in people who are suffering from biotin deficiency is seborrhoeic dermatitis. This disease causes flaking and itching on the scalp that may lead to balding. Children who are affected by this condition may suffer from muscle pain and hair problems. Symptoms such as thinning of hair, red-scaly skin and brittle nails are common signs of biotin deficiency. A proper supplement of biotin may reduce muscle cramps in kids.

Biotin deficiency manifests in symptoms such a hair loss, a scaly red rash in the face around the mouth, nose, eyes, and genitals, as well as depression, lethargy, hallucination, and peripheral neuropathy, such as tingling and numbness of the arms and legs.

Summary:

• Biotin is a coenzyme that is used in the metabolism of lipids, proteins, and carbohydrates.

• Biotin is known for maintaining hair, skin, and nails.

• Biotin is found in many natural food sources.

• References:

• Bullock, W.,2008, Nursing files, “life ahead vitamin deficiencies”. Poland. Page 346.

• ChemistryOfLife.com.ph

• www.wikipedia.net

• http://dailyglowp465.com.marivick graham.ph

• Thank You!