January 2013

LEADING

REGENERATIVE

MEDICINE

This presentation is intended to present a summary of ACT’s (“ACT”, or “Advanced Cell

Technology Inc”, or “the Company”) salient business characteristics.

The information herein contains “forward-looking statements” as defined under the federal

securities laws. Actual results could vary materially. Factors that could cause actual results

to vary materially are described in our filings with the Securities and Exchange Commission.

You should pay particular attention to the “risk factors” contained in documents we file from

time to time with the Securities and Exchange Commission. The risks identified therein, as

well as others not identified by the Company, could cause the Company’s actual results to

differ materially from those expressed in any forward-looking statements. Ropes Gray

Cautionary Statement Concerning Forward-Looking Statements

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ACT is a publicly-traded biotechnology company

• Develop cellular therapies for the treatment of diseases and conditions that impact hundreds of millions of people worldwide

• Premier scientific and research development team

• Cell therapies are traditionally derided for being high cost, high touch and having lack of scalability. Not our approach at all

>> Centralized, Scalable, Cost Effective Cell Therapy Products <<

About ACT:

– Ticker – ACTC

– Market Capitalization: $160 million

– Principal lab and GMP facility: Marlborough, MA

– Corporate HQ: Santa Monica, CA

– Only hESC-derived tissue trials ongoing worldwide

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Company Overview

Multiple Pluripotent Cell Platforms

Single Blastomere-derived

Embryonic Stem Cell Lines

Generating hESC lines

WITHOUT DESTRUCTION OF EMBRYO

Utilizes a

SINGLE CELL BIOPSY

ACT never needs to make another hESC line again

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Final Product Definition: hESC-derived

products will be manufactured using

a cell line made in 2005 from single

cell isolated without the destruction of any embryos

Multiple Pluripotent Cell Platforms

Induced Pluripotency Stem Cells (iPS)

• Early Innovator in Pluripotency

(before iPS was even a term!) • Controlling Patent Filings (earliest priority date)

to use of OCT4 for inducing pluripotency

• Science is moving quickly, but

Regulatory Agencies (FDA, EMA)

proceeding carefully

• ACT pursuing platelets as first

iPS-derived product (cell fragments – no nucleus,

not mitotically active)

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RPE Clinical Program

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Structure of Retina

The Retina the light-sensitive tissue lining the inner surface of

the eye

Retina

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Life Support to Photoreceptors

Provides nutrients and growth factors

• photoreceptors see no blood

Recycles Vitamin A

• maintains photoreceptor excitability

Detoxifies photoreceptor layer

Maintains Bruch’s Membrane

• natural antiangiogenic barrier

• immune privilege of retina

Absorbs stray light / protects from UV

RPE Layer has

multiple critical roles

in the

health and function

of photoreceptors and the retina as a whole.

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Life Support to Photoreceptors

Loss of RPE cells

Build up of toxic waste

Loss of photoreceptors

Dry AMD

Bruch’s Mem. dehiscence

Choroidal neovascularization

Wet AMD

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RPE Therapy- Rationale

Dry AMD represents more than

90%

of all cases of AMD

North America & Europe

alone have more than 30 million dry AMD patients

who should be eligible for our RPE cell therapy

What if we could

replace missing RPE cells?

RPE cell therapy may impact

over 200 retinal diseases

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RPE Therapy- Rationale

• Massive unmet medical need

• Unique measuring and observation environment

• Easy to identify – aids manufacturing

• Small dosage size – less than 200K cells

• Immune-privileged site - minimal/no immunosuppression

• Ease of administration - no separate device approval

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RPE Therapy- Rationale

U.S. PATIENT POPULATION

EARLY STAGE (10-15M)

INTERMEDIATE (5-8M)

LATE STAGE (1.75M)

ACT’S RPE Cell Therapy should address the full range

of dry AMD patients:

Halt progression of vision loss in early

stage patients

Restore some visual acuity in later

stage patients

GMP process for differentiation and purification of RPE – Virtually unlimited supply from stem cell source

– Optimized for manufacturing

Ideal Cell Therapy Product

– Centralized Manufacturing

– Small Doses

– Easily Frozen and Shipped

– Simple Handling by Doctor

GMP Manufacturing

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Product Cold Chain is Easily Scaled for Global Sales

Preclinical - Examples

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control treated

Injected human RPE cells

repair monolayer structure in

eye

Photoreceptor

layer

photoreceptor layer

is only 0 to 1 cell

thick without

treatment

Phase I - Clinical Trial Design

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SMD and dry AMD Trials approved in U.S., SMD Trial approved in U.K.

12 Patients / trial

ascending dosages of 50K, 100K, 150K and 200K cells.

Regular Monitoring - including high definition imaging of retina

50K Cells 100K Cells 150K Cells 200K Cells

Patient 1 Patients 2/3

DSMB Review DSMB Review

Participating Retinal Surgeons

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Steven D. Schwartz, MD Chief, Retina Division

Ahmanson Professor of Ophthalmology

Director, Diabetic Eye Disease and Retinal Vascular Center

Director, Ophthalmic Photography Clinical Laboratory

Jules Stein Eye Institute

Wills Eye Institute

Carl D. Regillo, MD Director, Retina Service

Professor of Ophthalmology, Jefferson Medical College

Byron L. Lam, MD Director, Clinical Visual Physiology

Professor of Ophthalmology

Bascom Palmer Eye Institute

Participating Retinal Surgeons

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Dean Eliott, MD Associate Director, Retina Service

Professor, Harvard Medical School

Massachusetts Eye and Ear Infirmary

Moorfields Eye Hospital

James Bainbridge, MA MB BChir PhD FRCOphth Professor of Retinal Studies, UCL Institute of Ophthalmology

Philip J. Rosenfeld, MD PhD Professor of Ophthalmology

Bascom Palmer Eye Institute

Edinburgh Royal Infirmary

Baljean Dhillon BMed Sci, BM BS, FRCS Surgeon, Edinburgh Royal Infirmary

Surgeon, Lothian University Hospitals NHS Trust

Professor of Ophthalmology, University of Edinburgh

Professor of Visual Impairment Studies, Heriot Watt University

Surgical Overview

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Procedure:

• 25 Gauge Pars Plana

Vitrectomy

• Posterior Vitreous Separation

(PVD Induction)

• Subretinal hESC-derived RPE

cells injection

• Bleb Confirmation

• Air Fluid Exchange

Preliminary Results

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No Adverse Events

No signs of hyperproliferation,

abnormal growth, rejection or retinal

detachment.

Persistence of cells

Anatomical evidence of hESC-RPE

survival and engraftment.

Increased pigmentation within the bed

of the transplant.

Impact on Acuity

Recorded functional visual

improvements in both patients.

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Engraftment and Survival: SD-OCT image collected at month 3

show survival and engraftment of RPE

SMD001

3mo post-op

Preliminary Results – Structural

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Baseline

Injection site

Month 1 Month 2

SMD PATIENT UK04

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Baseline

Injection site

Month 1 Month 3

SMD PATIENT UK03

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Baseline 2 months

DRY AMD PATIENT 204

Preliminary Results – Functional

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Visual Acuity Measurements

• SMD Patient: BCVA improved from hand motions to 20/800 and

improved from 0 to 5 letters on the ETDRS visual acuity chart

• Dry AMD Patient: Vision improved in the patient with dry age-

related macular degeneration (21 ETDRS letters to 28)

14 month Follow-up:

• Visual acuity gains remain relatively stable for both patients

• SMD Patient continues to show improvement.

U.K. SMD01 Patient (at 9 month follow-up)

• ETDRS: Improved from 5 letters to 10 letters, and stable

• Subjective: Reports significantly improved ability to read text on TV

Current Safety Profile – Stargardt’s Trial

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12 SMD Patients Treated

3 patients (50K cells cohort) treated – US Trial > Cohort Complete

3 patients (50K cells cohort) treated – UK Trial > Cohort Complete

3 patient (100K cells cohort) treated – US Trial > Cohort Complete

3 patient (100K cells cohort) treated – UK Trial > Cohort Complete

No reports of any adverse events or complications due to

cells per se • No evidence of inflammation or infiltration

• No evidence of ectopic tissue formation

• No evidence of retinal detachment

Current Safety Profile – Dry AMD Trial

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6 dry AMD Patients Treated

3 patients (50K cells cohort) treated > Cohort Complete

3 patient (100K cells cohort) treated > Cohort Complete

No reports of any adverse events or complications due to

cells per se • No evidence of inflammation or infiltration

• No evidence of ectopic tissue formation

• No evidence of retinal detachment

RPE Program Milestone Objectives

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Key upcoming milestones

• Continue to treat and review patient data

• Define efficacy endpoints and targeted patient visual

criteria

• Treat earlier stage disease to determine curative

power of dissociated cell injections

• Simplify shipping and cell-prep to enhance scaled

distribution platform

Intellectual Property – RPE Program

Treatment Dominant Patent Position for Treating Retinal

Degeneration

Manufacturing Broad Coverage for Manufacturing RPE Cells from hESC

Preparations Claims directed to pharmaceutical preparations of RPE

Cells from hESC, including both cell suspensions and

scaffolded RPE layers.

Sources Issued patents cover RPE Cells derived from other

pluripotent stem cells (including iPS cells)

Vigilance Regularly Filing on Improvements • Extend patent life cycle, with significance to commercialization

• Include composition-of-matter claims (cell preparations,

pharmaceutical preparations, etc.)

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Price Justification

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Unmet Therapeutic Need

Efficacy

Patient Prevalence

Pharmacoeconomics

Patient Advocacy

Pricing Justification

across all categories

of consideration

RPE Program - Investment Thesis

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• Immense unmet medical need

• Small Doses

• Immunoprivileged – permits central (allogeneic) source of cells

• Noninvasive monitoring of retina

Market potential: More than 50 million patients in major markets.

1% market penetration may represent $5-10B market opportunity.

Orphan indications are meaningful: Estimating a 10% market penetration

with reoccurring treatments every 3-5 years, Stargardt’s disease can be a

$100+ million/year product.

Therapeutic Pipeline -

Ocular Programs

Retinal Pigment Epithelial Cells

Macular Degeneration - dry AMD

Retinitis Pigmentosa

Photoreceptor protection

Hemangioblast cells

Ischemic retinopathy

– diabetic retinopathy, vascular occlusions

Retinal Neural Progenitor cells

Isolated Protective Factors

Photoreceptor Loss, Modulation of Müller Cells

Protection of Retinal Ganglion cells (Glaucoma)

Corneal Endothelium, Corneal Epithelium,

Descemet’s Membrane

Corneal Disease

Mesenchymal Stromal Cells

Glaucoma, Uveitis

Retinitis Pigmentosa

Management of Ocular Surfaces

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Retina

Mesenchymal Stem Cell Program

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Mesenchymal Stem Cells in Therapy

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Mesenchymal stem cells (MSCs) regulate immune responses

provide therapeutic potential for treating autoimmune or

inflammatory diseases.

• Allogeneic - without HLA matching.

• Track Record - Adult-derived MSCs already in 200+ clinical trials. Derived from Bone Marrow and Adipost Tissue

However, allogeneic adult-derived MSC’s are limited

by replicative senescence, and as it turns out, a relative

lack of potency

hESC- and iPS – derived MSC

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ACT Proprietary Process • hESC- and iPS-derived MSCs

• virtually inexhaustible source of starting material

• replicative capacity is more than 33,000 times greater

Advantages for Manufacturing • Use Single Master Cell Bank

• Simplifies FDA/regulatory process

• No need for continually finding and qualifying

donors

• Less labor-intensive

Potential applications

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• >100 autoimmune diseases

• Multiple Sclerosis

• Osteoarthritis

• Crohn’s Disease/IBS

• Aplastic Anemia

• Chronic Pain

• Limb Ischemia

• Heart Failure/MI

• Stroke

• Graft-versus-host Disease

• Spinal Cord Injury

• Parkinson’s Disease

• Liver Cirrhosis

• Emphysema/Pulmonary Diseases

• Wound healing

(ulcers/decubitus/burns)

• HSC engraftment/irradiated

cancer patients

• Eye diseases (uveitis, retinal

degeneration, glaucoma)

ACT

Blood Components Program

Hemangioblast Program: Overview

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Hemangioblast: common precursor to hematopoietic and endothelial cells.

Multipotent cell produces all

cell types in the circulatory and

vascular systems

Generation of Blood Products

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Hemangioblasts RBCs Hemangioblasts Enucleated

RBC’s

Process generates large

quantities of functional

red blood cells and

megakaryocytes &

platelets

The Case for Platelets

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Platelets are key elements of

hemostasis and thrombosis as well as

tissue regeneration after injury or surgery.

• Maintain vascular integrity and play vital roles in wound repair

• Thrombocytopenia is a major cause of morbidity in sepsis,

cancer and preeclampsia

• Used regularly in soft- and hard-tissue applications in most fields

of surgery.

.

Beyond Donor Supply: Estimate

demand for additional 1-2M units/year

The Case for Platelets

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Donor-derived platelets raise concerns:

• variability of quality and quantity

• risk of infectious transmission

• short lifespan of stored platelets

• bacterial contamination during storage

• development of alloantibodies in multi-transfused patients

Platelets are the blood product most difficult to

maintain without unnecessary wastage. • Platelets do not tolerate refrigeration.

• Storage at room temperature is limited to 5–7 days

Need for new strategies to generate platelets for infusion therapy.

Platelets 2.0

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Ability to control platelet manufacturing provides

opportunities to improve storage, fine tune

platelets for use in wound healing applications, as well

as to engineer new roles for platelets beyond

traditional involvement in wound healing.

• Improve cryopreservation of platelets

• Make lyophilization of platelets tractable solution

• Utilize platelets for drug delivery

• Utilize platelets in imaging (load with contrast agents)

CONFIDENTIAL - BUSINESS PROPRIETARY

Platelet Production Stages

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Stem Cell

Promegakaryoblast

megakaryoblast

Promegakaryocyte

PFC: Proplatelet

Formation Cell

Platelets

Stage I Stage II Stage III

Stage IV

CFU-GEMM BFU-MK CFU-MK

endomitosis

Size and Polyploidy

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Average size (diameter) of cells

at the beginning and 6 days after MK culture

DNA ploidy analysis by flow cytometry of CD41a+ cells.

DNA ploidy up to 32N was observed in these cells.

Platelets

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Bone Marrow

Limited By Source Infinite Supply

Cord Blood hESC

Representative iPS-platelet prep

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Blood platelets iPS platelets

CD42b

CD

41a

Achieving Function and Scale

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• Ultrastructural and morphological features of SC-derived platelets are

indistinguishable from normal blood platelets.

• SC-derived platelets respond to thrombin stimulation, form

microaggregates, and facilitate clot formation and retraction.

• SC-platelets form lamellipodia and filopodia in response to thrombin

activation, and tethered to each other as observed in normal blood.

• SC-derived platelets contribute to developing thrombi at sites of laser-induced

vascular injury in mice - first evidence for in vivo functionality of SC-

derived platelets.

Activation

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iPS-PLT’s display appropriate

cytoskeletal function

in glass spreading assays.

Characterization of Platelets

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hESC- and iPS-derived platelets participate

in clot formation and retraction

Clinical Program Status

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• Animal model studies show

proper in vivo function

• Achieved clinical dose

scale manufacturing

• Completely feeder-free process

(bioreactor capable!)

• Pre-IND meeting requested

with FDA

Human platelets incorporating into

laser-induced into mouse thrombus

ACT Corporate Overview

Financial Update – Strong Balance Sheet

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• Company ended 2012 Q3 with $42 million in cash or

availability of cash through financing commitments

• $16 million annual cash-burn rate

(funded through early 2015)

• Settled nearly all litigation hangover from previous

management

ACT Management Team

Highly Experienced and Tightly Integrated Management Team

Gary Rabin – Chairman & CEO

Dr. Robert Lanza, M.D. – Chief Scientific Officer

Edmund Mickunas – Vice President of Regulatory Affairs

Dr. Irina Klimanskaya, Ph.D. – Director of Stem Cell Biology

Dr. Shi-Jiang (John) Lu, Ph.D. – Senior Director of Research

Dr. Roger Gay, Ph.D. - Senior Director of Manufacturing

Kathy Singh - Controller

Rita Parker – Director of Operations

Dr. Matthew Vincent, Ph.D. – Director of Business Development

Bill Douglass – Dir. of Corporate Communications & Social Media

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Dr. Ronald M. Green: Chairman

Dr. Judith Bernstein

Dr. Jeremy B.A. Green

Dr. Robert Kauffman

Dr. Carol A. Tauer

ACT Leadership

Gary Rabin: Chairman & CEO

Dr. Robert S. Langer, ScD: Prolific medical inventor; Chair – ACT SAB

Gregory S. Perry: EVP – Immunogen

Michael Heffernan: CEO – Collegium Pharma

Zohar Loshitzer: CEO Presbia; Founder LifeAlert Medical

Dr. Alan C. Shapiro: Renowned business school professor

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World Class Board of Directors

Highly-regarded Ethics Advisory Board

Thank you

For more information, visit www.advancedcell.com