Biophysical Immunology Laboratory Thomas Vorup-Jensen Institute for Medical Microbiology and Immunology University of Aarhus Denmark Innate Immunity Janeways Immunobiology Chapter 2&3 Lecture I:(mainly) Cellular factors Important messanges: Important cell types supporting innate immunity effector functions Important molecular mechanisms in leukocyte functions Molecules of microbial origin triggering an innate immune response 2 Humoral Immune response Chap. 10 Antigen capture Chap. 4-6 Cell mediated immunity Chap. 8&9 Immune pathogenesis (autoimmunity & cancer) Several chap. INNATE IMMUNITY Innate immunity: a role everywhere in the immune system 3 Figure 8-1 4 Figure 8-6 5 6 (macrophages are diffrentiated monocytes) 7 8 9 Further differentiation to macrophage, DC 10 (e.g. defensins, lysozyme) 11 Time (adaptive immunity) 12 13 14 15 16 Innate Immunity Janeways Immunobiology Chapter 2&3 Lecture I:(mainly) Cellular factors Important message !: Innate immunity protects the body against infection in the early phases of infection Damage to the host may occur as a consequence of innate immunity effector functions inflammation may be excessive 17 How to trigger the complement system: Discrimination between self and non-self by pattern recognition Janeway (1989) Cold Spring Harb Symp Quant Biol 54: 19 20 Mogensen (2010) Clin. Rev. Microbiol. 22: 22 23 24 Innate Immunity Janeways Immunobiology Chapter 2&3 Lecture I:(mainly) Cellular factors Important message !: Many molecules in innate immunity recognize patterns on microbial surfaces. This recognition leads to triggering on the immune response. 25 26 27 28 29 Innate Immunity Janeways Immunobiology Chapter 2&3 Lecture I:(mainly) Cellular factors Important message !: Innate immunity triggers the production bactericidal compounds and cytokines that control cell migration 30 31 32 33 34 35 37 Downloaded from: StudentConsult (on 29 October :52 PM) 2005 Elsevier 38 Carman (2009), J Leuk Biol 122: 40 41 Innate Immunity Janeways Immunobiology Chapter 2&3 Lecture I:(mainly) Cellular factors Important message !: Adhesion molecules play an important role in supporting contact between leukocytes and inflammed tissue during migration and phagocytosis. 42 43 Viruses: typically a job for the aqcuired immune system 44 45 46 47 48 49 50 51 Innate Immunity Janeways Immunobiology Chapter 2&3 Lecture II:(mainly) Soluble (humoral) factors Important messages: Important soluble molecules supporting innate immunity effector functions Connection between molecular structure and function in the immune system to be continued 52