Biomedical applications of molecular imaging

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Biomedical applications of molecular imaging. Tony Lahoutte UMons Nov-Dec 2011. Course 1. Part 1: Introduction and general principles. Biomedical Imaging. R önt gen. Hand of Anna Berthe 1895. Biomedical Imaging. R önt gen. 22 dec 1895 Hand of Anna Berthe. 23 January 1896 - PowerPoint PPT Presentation

Transcript of Biomedical applications of molecular imaging

  • Biomedical applications of molecular imagingTony LahoutteUMonsNov-Dec 2011

  • Course 1Part 1: Introduction and general principles

  • Biomedical ImagingRntgenHand of Anna Berthe1895

  • Biomedical ImagingRntgen22 dec 1895Hand of Anna Berthe

    23 January 1896Hand of Albert von Klliker

  • Biomedical ImagingWeissleder and Pittet, Nature 2009

  • Biomedical Imaging1. Microscopy: In vitro samples or in vivo tissues2. Preclinical Imaging: In vivo imaging in animal models3. Clinical Imaging: Imaging in patients

  • Biomedical Imagingwww.mi-central.org

  • Biomedical ImagingAnatomical imaging: Organ and tissue morphologyPhysiologic Imaging: Organ and tissue functionMolecular Imaging: Molecules and cells

    MolecularAnatomyPhysiologyCell

  • Molecular ImagingDefinition:Molecular imaging is the visualization, the characterization and the measurement of biological processes at the molecular and cellular levels in living systems

  • Anatomical MolecularHybrid Imaging

  • AnatomicalCT scanof a women

  • MolecularGlucosemolecules

  • PET-CT scanComputed Tomography or CT scanAnatomical

    Positron Emission Tomography or PET scanMolecular

  • Anatomical + MolecularPET/CT fusion image

  • Anatomical

  • MolecularRadiolabeled antibody fragments that recognize cancer cells

  • SPECT-CT

  • Anatomical + MolecularSPECT/CT fusion image

  • AnatomicalMRI scan

  • Anatomical + Molecular

  • PET/MRI scannerCourtesy of University of Tbingen

  • FMT/MRIJ. Chen, JCI, 2009: Combined magnetic resonance and fluorescence imaging of the living mouse brain reveals glioma response to chemotherapyFluorescence Molecular Tomography/ Magnetic Resonance Imaging= FMT/MRIMRIFMT

  • FMT/CTFMT/CT fusion

    Nature 2008;452:580-589

  • FMT scannerVisen

    Imaging Near Infrared Fluorescence

  • Anatomical + MolecularPET/CTSPECT/CTPET/MRIFMT/MRIFMT/CT=Hybrid imaging

  • Physiological Imaging= Functional Imaging visualizing cardiac contraction Imaging blood perfusion ...

  • Planar and Tomographic ImagingPlanar = 2D projection

    Tomographic = 3D volume

  • Planar and Tomographic ImagingGamma Camera

  • Planar and Tomographic ImagingPlanar = 2D projectionAnterior and posterior view of a planar bone scintigraphy

  • Planar and Tomographic ImagingTomographic = 3D volume

  • Static and Dynamic ImagingStatic image= 1 time interval

    Dynamic image = multiple time intervals

  • Static and Dynamic ImagingStatic image = 1 time intervalStatic image of a radiolabeled antibody between 1-10 s after intravenous injection in a rat

  • Static and Dynamic ImagingDynamic image = multiple time intervalsDynamic image of a radiolabeled antibody between 1second and 10 min after intravenous injection in a rat. Every frame is 10 seconds

  • Special case of dynamic: Gated ImageGated image = images are synchronized with cardiac contraction or respiration

  • Special case of dynamic: Gated ImageGated image = images are synchronized with cardiac contraction or respiration

  • Static and Dynamic ImagingDifferent combinations are possible:

    Static planar imageDynamic planar imageStatic tomographic imageDynamic tomographic image

  • Slicing and orientation

  • Slicing and orientationTransverseSagittalCoronalRRAALL

  • Slicing and orientationOrientation: we look from the feet to the headRL

  • Slicing and orientationOrientation: we look from the feet to the headRL

  • Slicing and orientationOrientation: we look from the feet to the headRL

  • Slicing and orientationOrientation: we look from the feet to the headRL

  • Slicing and orientationOrientation: we look from the feet to the headRL

  • Slicing and orientationOrientation: we look from the feet to the headRL

  • Slicing and orientationOrientation: we look from the feet to the headRL

  • End of part 1

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