Biological Effects of Radiation - Trainex Bio effects.pdf · Biological Effects We know more about...
Transcript of Biological Effects of Radiation - Trainex Bio effects.pdf · Biological Effects We know more about...
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Biological Effects of Radiation
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What are the effects from radiation?
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Radioactive Material can be Harmful !
It need not be feared; But it MUST command your respect Even as small as 1 Nanocurie (1 x 10 -9 Curie)
if deposited in the right place can cause cancer.
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Biological Effects We know more about biological effects with
ionizing radiation than other environmental factors.
Four large groups of people provided data: Early Radiologist Atomic bomb survivors Large accidents (Chernobyl) Radiation therapy patients
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Chernobyl Reactor Accident
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Chernobyl Radiation and Trauma Injuries
Acute Deaths: 31
Injuries and Hospitalizations: 300
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An acute exposure may only be to a part of the body.
Analytical x-ray machines may deliver doses of several millionmrem in a few seconds!
Accidents have resultedin the loss of fingers.
Strong beta emitters(P-32) can provide largedoses to the hands.
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Injury from X-ray Source
6 - 21 Weeks after exposure. Small ulcerated present.
After skin grafting18 – 21 months after exposure.Tissue necrosis.
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1945 criticality Accident @ Los ALomos
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General Public Perceptions
Common Views Mysterious Cannot detect by our five senses Sinister Unknown Danger Deadly Causes Cancer
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Media Perceptions
Media avoids complex risk assessments with only two words:
-Deadly Radiation-Lethal radioactivity-Ticking Time bomb-Toxic substances-Hazardous wastes
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General Scientific Perceptions
Scientists’ Views-Part of natural world-Easily measurable-Risks are well known-Major benefit in medicine-Cures Cancer
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Risks Associated With Occupational Exposure
Is There a Safe Level of Exposure to Ionizing Radiation ?
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Dose vs. Effect
LD 50 = 450 RADs to Whole Body(Gamma Radiation)
LD 50 = 400 RADs to Whole Body(30 Day Exposure)
(4 Gray = 400 RADs)
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Acute Radiation Syndrome
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Other Levels
100 RADs to Whole Body- Skin Redness- Hair Loss- Skin Cancer- Onset of radiation syndrome
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Other Symptoms
Nausea / Vomiting Malaise & Fatigue Increased Body Temperature Hemopoietic Syndrome – Blood
(100 RAD - Gamma) Gastrointestinal Syndrome (400 RADs
Gamma) Central Nervous System Syndrome
(1000 RADs - Gamma)
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Some Everyday Risks
Same Chance of Death (1 in 1,000,000)300 Mile Automobile RideEat 40 Tablespoons of Peanut ButterLiving 2 Days in BostonDrinking 0.5 Liter of WineLiving with a Smoker for 2 Months2.5 mRem to Whole Body
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Dose vs. Effect
Hiroshima Nagasaki Czech Mine Workers Industrial Accidents Military Accidents Medical Accidents Chernobyl
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High Dose Effects
But What About Low Dose Effects ?
Does ZERO Dose EQUAL ZERO Risk ?
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Acute Effects of Exposure
Skin Redness (Sunburn-like)
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Radiation Therapy Accident
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Very Lucky Lady!
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Health Effects
SomaticTissue DamageSkin RednessHair LossSterilityCancer
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Biological effects depends on whether it is an ACUTE DOSE or a CHRONIC
DOSE.
ACUTELarge dose in a short time
CHRONICSmall does over a long time
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Health Effects
GeneticMutations
DNA DamageBirth Defects
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Risks Associated With Occupational Exposure
Delayed EffectsCancer
Bone CancerLung Cancer
LeukemiaCataracts
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Annual Exposure Limits
Whole Body 5,000 mRem
Skin 30,000 mRem
Eyes 15,000 mRem
Hands, Feet, Arms 75,000 mRemAnkles (Extremities)
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Women of Reproductive Age
Lower Exposure Limits:
500 mRem per YearNo More Than 40 mRem / Month !First Trimester is most Sensitive Time
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Modes of Exposure
ExternalIrradiationExternal Surface Contamination
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Understanding Exposure
Exposure may be known and recognized or clandestine as:
>large radiation exposures, such as a nuclear bomb or catastrophic damage to a nuclear power station
>small radiation source emitting continuous gamma radiation producing chronic intermittent exposures( such as radiological sources from medical treatment)
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Understanding Exposure Cont’d
>skin contamination with radioactive material (“external contamination”)
>internal radiation from absorbed, inhaled, or ingested radioactive material ( “ internal contamination”)
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External Contamination
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Internal Contamination
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Modes of Exposure
InternalAvoid:
>Inhaling It>Absorbing It thru Your Skin>Eating It>Getting Punctured by a
Contaminated “Sharp”
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“ Enough Said … ”