Biofilm in fungal infections and therapeutic approaches ...fisftrust.org/upload/ebooks/ppt2.pdf ·...
Transcript of Biofilm in fungal infections and therapeutic approaches ...fisftrust.org/upload/ebooks/ppt2.pdf ·...
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Biofilm in fungal infections and therapeutic
approaches for infections caused by biofilm
forming fungi
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The NIH estimates that 80% of human infections result from
pathogenic biofilms
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• Clinically, biofilm infections represent an overwhelming problem due to the highly recalcitrant nature of the embedded microbes, which are resistant to both antimicrobial drugs as well as host defenses
• Biofilms are a protected niche for microorganisms, where they are safe from antimicrobial treatment and can create a source of persistent infection
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Quorum Sensing
• Allows bacteria /fungus to monitor the
environment for other bacteria/fungi and to
alter behavior on a population-wide scale in
response to changes in the number and/or
species present in a community.
• Quorum sensing confuses the distinction
between prokaryotes and eukaryotes because
it enables microbes to act as multicellular
organisms
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Mechanism of Resistance in a biofilm
• Penetration of drugs is diminished
• Inhibited growth of the organism
• Upregulated Gene expression of efflux pumps
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Targetting Micobes
• Blast them
• Fool them
• Do not irritate them