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Contents

Cell & Tissue Engineering ..........................................3

Design & Rehabilitation ......................................14

BioMEMS..............................................................17

Solid & Fluid Mechanics ......................................19

Biotransport..........................................................25

General Books in Bioengineering ........................27

Forthcoming ........................................................37Page 3

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3

Cell & Tissue Engineering

For more information and complete contents, visit www.crcpress.com

Red Blood Cell AggregationOguz BaskurtAkdeniz University, Turkey

Björn NeuNanyang Technology University, Singapore

Herbert J. MeiselmanUniversity of Southern California, USA

Red blood cells in humans—and most othermammals—have a tendency to form aggregateswith a characteristic face-to-face morphology,similar to a stack of coins. Known as rouleaux,these aggregates are a normally occurring phe-nomenon and have a major impact on bloodrheology. What is the underlying mechanismthat produces this pattern? Does this really hap-pen in blood circulation? And do these rouleauxformations have a useful function? The first book to offer a comprehensive review ofthe subject, Red Blood Cell Aggregation tacklesthese and other questions related to red bloodcell (RBC) aggregates. The book covers basic,clinical, and physiological aspects of this impor-tant biophysical phenomenon and integratesthese areas with concepts in bioengineering. Itbrings together state-of-the-art research on thedeterminants, mechanisms, and measurementand effects of RBC aggregation as well as onvariations and comparative aspects. After an introductory overview, the book out-lines factors and conditions that affect RBCaggregation. It presents the two hypotheses—the bridging model and the depletion model—that provide potential mechanisms for the adhe-sive forces that lead to the regular packing of thecells in rouleaux formations. The book alsoreviews the methods used to quantify RBCaggregation in vitro, focusing on their impor-tance in clinical practice. Chapters discuss theeffect of RBC aggregation on the in vitro rheolo-gy of blood as well as on tube flow. The book also looks at what happens in the cir-culation when red blood cells aggregate andexamines variations due to physiological andpathophysiological challenges. The concludingchapter explores the formation of red blood cellaggregates in other mammals. Written by lead-ing researchers in the field, this is an invaluableresource for basic science, medical, and clinicalresearchers; graduate students; and cliniciansinterested in mammalian red blood cells.

• Provides extensive coverage of the basicmechanisms of RBC aggregation and supporting experimental evidence

• Covers the in vivo hemodynamic mechanismsinfluenced by RBC aggregation, includingpathophysiological and clinical consequences

• Presents methods to measure RBC aggregation for research and clinical purposes

• Describes experimental methods to modifyRBC aggregation (in vitro and in vivo) andrelated hemodynamic methodology

• Discusses comparative data on RBC aggregation and related evolutionary concepts

• Contains more than 150 illustrations

• Includes extensive references at the end ofeach chapter for additional study

Selected Contents

Introduction

Determinants of Red Blood Cell Aggregation

Mechanism of Red Blood Cell Aggregation

Measurement of Red Blood Cell Aggregation

Effect of Red Blood Cell Aggregation on In VitroBlood Rheology

Effect of Red Blood Cell Aggregation on Tube Flow

In Vivo Hemodynamics and Red Blood CellAggregation

Alterations in Red Blood Cell Aggregation

Comparative Aspects of Red Blood CellAggregation

Index

Catalog no. K11945, September 2011, 318 pp.ISBN: 978-1-4398-4180-8, $119.95 / £82.00Also available as eBook


4 Save when you order online at www.crcpress.com


Coming Soon!

Biomaterials and Stem Cells in Regenerative MedicineEdited by

Murugan RamalingamUniversity of Strasbourg, France

Seeram RamakrishnaNational University of Singapore, Singapore

Serena BestUniversity of Cambridge, UK

Biomaterials and Stem Cells in RegenerativeMedicine bridges the gap in experimentalapproaches and understanding among the keyareas of biomedical research. It provides all-important aspects dealing with the basic scienceinvolved in structure and properties, techniquesand technological innovations in processing andcharacterizations, and applications of biomateri-als and stem cells in tissue regeneration. Thecoverage ranges from fundamental principles tocurrent technological advancements in themajor field of regenerative medicine at themacro/micro/nano/molecular scales. It includesbreakthroughs in biomaterials, stem cells, tissueengineering, and drug delivery and the currentperspectives of these key elements in the con-text of regenerative medicine.

• Provides a self-contained resource for understanding the current perspectives onbiomaterials and stem cells in regenerativemedicine

• Offers extensive coverage of a range of biomaterials and their interaction with stemcells and other cellular elements

• Covers different length scales such asmacro/micro/nano/molecular level

• Supplies an integrated approach to theorganization of materials science and engineering, micro/nanotechnology, bioengineering, and biomedical sciences

• Incorporates useful figures and tables withcurrent data

Selected Contents

Identification and Application of Polymers asBiomaterials for Tissue Engineering andRegenerative Medicine. Hydrogel as Stem CellNiche for In Vivo Applications in RegenerativeMedicine. Fabrication and Application ofGradient Hydrogels in Cell and TissueEngineering. Smart Biomaterial Scaffold for InSitu Tissue Regeneration. Fabrication of 3D

Selected Contents continued...

Scaffolds and Organ Printing for TissueRegeneration. Natural Membranes as Scaffold forBiocompatible Aortic Valve Leaflets: Perspectivesfrom Pericardium? Spatially DesignedNanofibrous Membranes for Periodontal TissueRegeneration. Auto-Inductive Scaffolds forOsteogenic Differentiation of MesenchymalStem Cells. Ophthalmic Applications ofBiomaterials in Regenerative Medicine. CalciumPhosphates as Scaffolds for Mesenchymal StemCells. Bioactive Glasses as CompositeComponents: Technological Advantages andBone Tissue Engineering Applications. ProcessingMetallic Biomaterials for a Better Cell Response.Osteogenic Adult Stem Cells and TitaniumConstructs for Repair and Regeneration. StemCell Response to Biomaterial Topography.Growth Factors, Stem Cells, and Scaffolds andBiomaterials for Tendon Regeneration.Biomaterials and Stem Cells for MyocardialRepair. Perinatal Stem Cells in RegenerativeMedicine. Adult Stem Cell Survival Strategies.Immunobiology of Biomaterial – MesenchymalStem Cell Interactions. Autologous MesenchymalStem Cells for Tissue Engineering in Urology.Umbilical Cord Matrix Mesenchymal Stem Cells:A Potential Allogenic Cell Source for TissueEngineering and Regenerative Medicine. HumanEmbryonic Stem Cells and Tissue Regeneration.Clinical Applications of Mesenchymal Stem Cell-Biomaterial Constructs for Tissue Reconstruction.Clinical Aspects of the Use of Stem Cells andBiomaterials for Bone Repair and Regeneration.Clinical Translation of Tissue Engineering andRegenerative Medicine Technologies.

Catalog no. K13711, June 2012, 608 pp. ISBN: 978-1-4398-7925-2, $149.95 / £95.00Also available as eBook


5



Nanobiomaterials HandbookEdited by

Balaji SitharamanState University of New York at Stony Brook, USA

Nanobiomaterials exhibit distinctive characteristics, including mechanical,electrical, and optical properties, which make them suitable for a variety ofbiological applications. Because of their versatility, they are poised to play acentral role in nanobiotechnology and make significant contributions tobiomedical research and healthcare. Nanobiomaterials Handbook offersbroad introduction for those new to the subject and serves as a useful ref-erence for advanced professionals.

Analyzing major topics and disciplines in thisarena, this volume:

• Defines the scope, current status, and futureprospects of nanobiomaterials

• Surveys nanobiomaterials and examines various synthesis and processing techniquesimportant for developing nanobiomaterials

• Explores the unique nanoscopic physico-chemical properties of nanobiomaterials

• Discusses potential applications, emphasizingunique challenges in the design, fabrication,and evaluation of biomaterials for a particularapplication or field

• Provides a detailed overview of the interactions between bionanomaterials/biological systems and the biocompatibilityissues associated with bionanomaterials

Advances in nanobiomaterials requires a multi-disciplinary approach spanning major fields inphysical and biological sciences, engineering,and medicine with considerable collaborationbetween ethicists, regulatory bodies, and indus-try. This volume brings together the work of ateam of world-renowned experts from variousfields who discuss the vast potential for nanobio-materials in a myriad of applications.

Selected Contents

Nanobiomaterials: Current and FutureProspects. Multifunctional Gold Nanoparticlesfor Cancer Therapy. Synthesis, Processing, andCharacterization of Ceramic Nanobiomaterialsfor Biomedical Applications. Synthesis,Properties, Characterization, and Processing ofPolymeric Nanobiomaterials for BiomedicalApplications. Carbon-Based Nanomedicine.Synthetic and Toxicological Characteristics ofSilica Nanomaterials for Imaging and DrugDelivery Applications. Peptide-Based Self-Assembled Nanofibers for BiomedicalApplications. Electrostatically Self-Assembled

Selected Contents continued...

Nanomaterials. Peptide-Based Nanomaterialsfor siRNA Delivery: Design, Evaluation, andChallenges. Nucleic Acid Nanobiomaterials.Emerging Technologies in Nanomedicine.Nanomaterials for Therapeutic Drug Delivery.Nanobiomaterials for Nonviral Gene Delivery.Nanobiomaterials for Cancer-TargetingTherapy. Nanobiomaterials for OcularApplications. Nucleic Acid BasedNanobiosensing. Nanobiomaterials forMolecular Imaging. Gadolinium-BasedBionanomaterials for Magnetic ResonanceImaging. Nanostructured Materials forImproved Magnetic Resonance Imaging.Nanobiomaterials for Dual-Mode MolecularImaging: Advances in Probes for MR/OpticalImaging Applications. Nanoscale Probes for theImaging of RNA in Living Cells. Nanomaterialsfor Artificial Cells. Nanobiomaterials forMusculoskeletal Tissue Engineering.Nanocomposite Polymer Biomaterials for TissueRepair of Bone and Cartilage: A MaterialScience Perspective. Collagen: A NaturalNanobiomaterial for High-Resolution Studies inTissue Engineering. Nanotopography onImplant Biomaterials. NanoarrayBionanotechnology. PhotopatternableMultifunctional Nanobiomaterials.Nanobiomaterials for Preclinical Studies andClinical Diagnostic. Biocompatibility ofNanomaterials: Physical and ChemicalProperties of Nanomaterials Relevant toToxicological Studies, In Vitro and In Vivo.Hemocompatibility of Nanoparticles. Breakingthe Carbon Barrier: Nanobiomaterials andCommunal Ethics. Index.

Catalog no. 94661, June 2011, 737 pp.ISBN: 978-1-4200-9466-4, $169.95 / £108.00Also available as eBook




Coming Soon!

Biomaterials ScienceAn Integrated Clinical and Engineering ApproachEdited by

Yitzhak RosenSuperior NanoBioSystems, Washington DC, USA

Noel ElmanCambridge, Massachusetts, USA

Rather than approaching biomaterials sciencefrom just a materials science and engineeringperspective, this book also covers the clinicalside. The goal is to engage biomaterials engi-neers and physicians in a much-needed discus-sion that integrates both fields at many levels inorder to increase the rate of successful deploy-ment of biomaterials, lower the side effects ofsuch a deployment, and accumulate knowledgefor improving current methodologies and meet-ing future challenges. Leading contributorsaddress topics such as hemocompatibility, carcinogenesis, infections, cellular mechanisms,signal transduction, clinical trials, MEMS, nan-otechnology, FDA regulations, and ethical issues.

• Discusses hemocompatibility

• Covers biomaterials and carcinogenesis and infections

• Includes coverage of clinical trials of biomaterial designs

• Details the implementation of nanotechnologyand MEMs in biomaterials

• Addresses ethical issues and FDA standards

Selected Contents

Introduction

Principles of Clinical and EngineeringIntegration in Hemocompatibility

Medical Applications of Micro-Electro-Mechanical Systems (MEMS) Technology

Nanoparticles to Cross Biological Barriers

Biomaterials, Dental Materials, and DeviceRetrieval and Analysis

Biomaterials and the Central Nervous System:Neurosurgical Applications of Materials Science

Biomaterials in Obstetrics and Gynecology

Tissue Engineering: Focus on the CardiovascularSystem

Tissue Engineering: Focus on theMusculoskeletal System

Regulatory Challenges in Biomaterials: Focus onMedical Devices

Innovative Product Development andTechnology Adoption for Medical Applications

Appendix: Some Examples of FDA-ApprovedProducts

Catalog no. K10223, May 2012, c. 328 pp. ISBN: 978-1-4398-0404-9, $149.95 / £95.00Also available as eBook


7



New Edition of Bestseller!

An Introductionto BiomaterialsSecond EditionEdited by

Jeffrey O. HollingerCarnegie Mellon University,Pittsburgh, Pennsylvania, USA

The second edition of this popular text includesnine new chapters that provide a comprehensiveand up-to-date educational framework for bio-materials education. A new chapter on the biolo-gy of wound healing sets the stage for the basicrequirements of standardized biomaterials test-ing and explains the reactions between biomate-rials and the living system into which it isimplanted. The book explains in vitro and in vivotesting paradigms and provides numerous exam-ples in the chapters on experimental design, lab-oratory assays, and animal models. Emphasizingthe importance of the regulatory process, itdescribes how innovation in the biomaterialsprocess relates to patentability and inventorship.

• Covers wound healing biology and hostresponse to implanted biomaterials

• Examines the regulatory process, includingstandardized product testing

• Reviews the innovativeness of biomaterials,with inventorship and patents in mind

• Considers experimental design, basic scientificmethods, and statistics

• Contains end-of-chapter questions and answers

Solutions manual available upon qualifying course adoption

Selected Contents

Consensus Definitions, Fundamental Concepts,and a Standardized Approach to AppliedBiomaterials Sciences. Biology, Biomechanics,Biomaterial Interactions: Wound HealingBiology. Biology, Biomechanics, BiomaterialInteractions: Cellular Mechanics. Biology,Biomechanics, Biomaterial Interactions:Materials–Host Interactions. BiomaterialsTesting, Statistics, Regulatory Considerations,Intellectual Property: Standardized MaterialsTesting. Biomaterials Testing, Statistics,Regulatory Considerations, IntellectualProperty: Statistics. Biomaterials Compositions.Biomaterials Applications. Index.

Catalog no. K10637, November 2011, 644 pp.ISBN: 978-1-4398-1256-3, $119.95 / £48.99Also available as eBook

A LaboratoryCourse inBiomaterialsWujing XianUniversity of Illinois at Urbana-Champaign, USA

A teaching tool for instructors in biomaterials andbioengineering, this is a comprehensive labora-tory textbook. It trains readers in laboratory skills,data analysis, problem solving, and scientificwriting. It integrates a variety of principles thatinclude materials science, chemistry, biochem-istry, molecular and cell biology, and engineer-ing. Providing detailed descriptions, explana-tions, and illustrations of experiments, the textalso includes a series of questions and answers atthe end of each chapter to clarify concepts.Many of the experiments presented are adaptedfrom research papers to reflect current progressin biomaterials and bioengineering.

• Presents detailed, step-by-step descriptions oflab procedures and explanations for theunderlying principles

• Contains user-friendly graphic illustrations forthe experiments

• Provides a series of questions and answers atthe end of each chapter to clarify conceptsand induce critical thinking

• Includes text boxes with in-depth information,case studies, and lab tips

• Offers information on equipment, reagents,and supplies for instructors

Selected Contents

Basic Laboratory Skills. Module I: Drug Delivery:Controlled Release of Encapsulated Proteinfrom PLGA Microspheres. Module II: NaturalBiomaterials: Collagen and Chitosan. BasicLaboratory Skills II: Cell Culture andMicroscopy. Module III: BiocompatibilityTesting: Cytotoxicity and Adhesion. Module IV:Tissue Engineering: Organotypic Cultures ofSkin Equivalents. Module V: Bioceramics:Porous Hydroxyapatite Composite. Appendix:Answers. Index.

Catalog no. 75829, June 2009, 216 pp.Soft Cover, ISBN: 978-1-4200-7582-3$64.95 / £41.99

Lecture and Lab Textbooks for Your Biomaterials Courses





The Physiologyof Bioelectricityin Development,TissueRegeneration,and CancerEdited by

Christine E. PullarUniversity of Leicester, UK

Exploring their role in the physiology of develop-ment and wound repair and pathophysiologies,such as cancer, this book describes the impor-tance of biological electric fields and their use astools to influence tissue repair, regeneration, andcancer. The text considers the generation andmeasurement of these fields, intercellular com-munication regarding local electrical guidancecues, and the role of bioelectricity in tissue devel-opment, regeneration, wound repair, and cancer.

• Focuses on the most relevant topics poised to drive the next generation of medicalbreakthroughs

• Demonstrates the role of bioelectricity in thedirectionality and speed of cell migration,proliferation, apoptosis, differentiation, andorientation

• Discusses the role of bioelectricity in cancerprogression and the potential for bioelectricity-based therapies to target both the tumor andmetastatic cancer cells

• Features contributions from world-classexperts in the field

• Includes clinical applications and extensivereferences to enhance additional study

Selected Contents

Measuring Endogenous Electric Fields.Investigation Systems to Study the BiologicalEffects of Weak Physiological Electric Fields.Endogenous Bioelectric Signals as MorphogeneticControls of Development, Regeneration, andNeoplasm. Stem Cell Physiological Responses toNoninvasive Electrical Stimulation. ElectricalSignals Control Corneal Epithelial Cell Physiologyand Wound Repair. Physiological Electric FieldsCan Direct Keratinocyte Migration and PromoteHealing in Chronic Wounds. Electrical Control ofAngiogenesis. Inflammatory Cell Electrotaxis.Effects of DC Electric Fields on Migration of Cellsof the Musculoskeletal System. Neuronal GrowthCone Guidance by Physiological DC ElectricFields. ...

Catalog no. K11686, March 2011, 342 pp. ISBN: 978-1-4398-3723-8, $119.95 / £76.99Also available as eBook

Nanotechnologyin TissueEngineering andRegenerativeMedicineEdited by

Ketul PopatColorado State University, Fort Collins, USA

Skillfully edited, with contributions from an expertpanel of researchers, Nanotechnology in TissueEngineering and Regenerative Medicine dis-cusses the use of nanotechnology for medicalapplications with a focus on its use for drug deliv-ery and tissue engineering. It sheds light on thechallenges facing the field and examines researchthat may provide solutions.Topics covered include:• Patterning of biomimetic substrates with AFM

lithography, primarily focusing on DPN nanotemplating polymer melts

• Nanotechnology-based approaches in thetreatment of injuries to tendons and ligaments

• Progress in the use of electrospinning processing techniques for fabricating nanofiberscaffolds for neural applications

• Nanotopography techniques for tissue-engineered scaffolds and the effects of nanotopography on cells and tissues

• Vertically aligned TiO2 nanotube surface structuring for optimization of Ti implants utilizing nanotechnology

• Applications originating from the harmony ofnanotechnology to biological systems, especiallyfor the regeneration in the nervous system

• Current understanding of the mechanisms bywhich cells sense nano-scale structure at themolecular level and how this understandingcan be useful in developing novel antifoulingmaterials

While there are books available on tissue engi-neering and nanotechnology and others aboutregenerative medicine, most do not comprehen-sively cover applications of nanotechnology toboth these areas. Focusing chiefly on drug deliv-ery, tissue engineering, and regenerative medi-cine, the book uses an application-basedapproach to relate laboratory-based research tothe development of technologies that can bereadily adaptable to an industrial environment.

Catalog no. K10090, November 2010, 302 pp.ISBN: 978-1-4398-0141-3, $125.95 / £80.99Also available as eBook



9



Cell MechanicsFrom Single Scale-Based Models toMultiscale ModelingEdited by

Arnaud Chauvière,Luigi Preziosi, and Claude VerdierUbiquitous and fundamental in cell mechanics,multiscale problems can arise in the growth oftumors, embryogenesis, tissue engineering, andmore. Cell Mechanics: From Single Scale-BasedModels to Multiscale Modeling brings togetherinsight and research on mechanical, mathemati-cal, physical, and biological approaches for simu-lating the behavior of cells, specifically tumor cells.The first part of the book discusses the powerfultool of microrheology for investigating cellmechanical properties, multiphysics and multi-scale approaches for studying intracellular mecha-nisms in cell motility, and the role of subcellulareffects involving certain genes for inducing cellmotility in cancer. Focusing on models based onphysical, mathematical, and computationalapproaches, the second part develops tools fordescribing the complex interplay of cell adhesionmolecules and the dynamic evolution of the cellcytoskeleton. The third part explores cell interac-tions with the environment, particularly the role ofexternal mechanical forces and their effects on cellbehavior. The final part presents innovative mod-els of multicellular systems for developmental biol-ogy, cancer, and embryogenesis.This book collects novel methods to apply to cellsand tissues through a multiscale approach. It pres-ents numerous existing tools while stimulating thediscovery of new approaches that can lead tomore effective and accurate predictions ofpathologies.

• Illustrates how phenomena occurring atvarious scales can be modeled and coupled toaccount for multiscale aspects

• Discusses experimental and theoretical topics,including biological and complex modelingissues

• Links subcellular effects to cellular properties• Covers the modeling of cell migration and

multicellular systems• Examines cell interactions with the environment

Catalog no. C4548, January 2010, 482 pp.ISBN: 978-1-4200-9454-1, $125.95 / £80.99Also available as eBook

ComputationalHydrodynamicsof Capsules andBiological CellsEdited by

C. PozrikidisUniversity of Massachusetts, Amherst, USA

“This book gives a quite extensive overview of different possible formulations for the motion ofrigid or deforming particles and for the solutionof flow-induced deformations. A wide range ofnumerical and methodological approaches areillustrated … The presence of many numericalexamples allows one to appreciate the capabili-ties of the approaches proposed and provides use-ful reference material. … This book is a highlyvaluable reference for any graduate student orresearcher interested in cellular mechanics, bio-fluid dynamics, bio-rheology or, in general, appli-cations involving the transport of micro-capsulesor cells by a fluid.”

—Luca Formaggia, Mathematical Reviews, 2012a

A roadmap to the current state of the art in com-putational cellular mechanics and biofluiddynamics, this book provides a comprehensiveand rigorous introduction to the fundamentalconcepts, mathematical formulation, alternativeapproaches, and predictions of this evolving field.

• Covers advanced numerical methods for simulating the motion of rigid particles(platelets) and the flow-induced deformationof liquid capsules and cells enclosed by viscoelastic membranes

• Enables readers to compare solutions producedby different numerical approaches and assessthe efficiency of alternative formulations

• Provides MATLAB® code and other data on thebook’s website

Selected Contents

Flow-Induced Deformation of Two-DimensionalBiconcave Capsules. Flow-Induced Deformationof Artificial Capsules. A High-Resolution FastBoundary-Integral Method for MultipleInteracting Blood Cells. Simulating MicroscopicHemodynamics and Hemorheology with theImmersed-Boundary Lattice-Boltzmann Method.Front-Tracking Methods for Capsules, Vesicles,and Blood Cells. ...

Catalog no. K11057, June 2010, 327 pp.ISBN: 978-1-4398-2005-6, $135.95 / £87.00Also available as eBook





Nanotechnologyand TissueEngineeringThe ScaffoldEdited by

Cato T. LaurencinUniversity of Virginia,Charlottesville, USA

Lakshmi S. NairUniversity of Connecticut, Farmington, USA

With chapters written by world-famousresearchers involved with various facets of nanos-tructured scaffolds, this is the first resource thatbrings together research and background infor-mation on a complete range of engineeringprocesses that have led to the development of anumber of highly useful tissues. It details the fun-damental and advanced aspects of nanofabrica-tion and includes an examination of cellular inter-actions at the nanoscale level. The book also dis-cusses clinical implications and applications, mak-ing it a critical resource for clinicians, engineers,and other scientists seeking to advance the field.• Provides background information on the

importance of scaffolds in tissue engineering • Discusses the structure and functions of the

extra-cellular matrix • Includes a comprehensive detailing of cell

responses to nano-features • Offers the contributions of experts with

outstanding reputations in the field

Selected Contents

Section I: Importance of Scaffolds in TissueEngineeringTissue Engineering: The Therapeutic Strategy ofthe Twenty-First Century. Top-Down Analysis of aDynamic Environment. ...Section II: Effect of Nanostructures on CellularResponses and Tissue RegenerationCell Response to Nanoscale Features and ItsImplications in Tissue Regeneration: AnOrthopedic Perspective. ...Section III: Promising NanofabricationTechniques to Develop Scaffolds for TissueEngineeringElectrospun Polymeric Nanofiber Scaffolds forTissue Regeneration. Structure and MechanicalProperties of Electrospun Nanofibers andNanocomposites. ...Section IV: Applications of NanostructuredScaffolds in Biology and MedicineNanotechnologies in Neural Tissue Engineering. ...


BiomaterialsA Nano ApproachSeeram Ramakrishna,Murugan Ramalingam,T.S. Sampath Kumar, andWinston O. Soboyejo

There are several well-known books on the mar-ket that cover biomaterials in a general way, butnone provide adequate focus on the future ofand potential for actual uses of emerging nanon-technology in this burgeoning field.Biomaterials: A Nano Approach is written froma multi-disciplinary point of view that integratesaspects of materials science and engineering,nanotechnology, bioengineering, and bio-sciences. The book fills a glaring void in the lit-erature by providing a comprehensive discus-sion of biomaterials and a scientifically plausibleextrapolation of likely scenarios in which nan-otechnology could play a significant role. Theauthors introduce and examine basic concepts,processing methodologies, and techniquesinvolved in the preparation and characterizationof nanobiomaterials that are specific to biomed-ical applications.

A Self-Contained Book Illustrating Past,Present, and Future Trends in Biomaterials

Spanning from the historical development of bio-materials to advances in the field, the textdescribes how basic concepts in nanotechnologyare applied to the processing of novel nanobio-materials, including nanostructured metals andalloys. With its illustrative examples and presen-tation of applications, this text offers a solidframework for understanding present and futuretrends of biomaterials in human healthcare sys-tems. It is an ideal companion resource for stu-dents, researchers, and industrial scientists whospecialize in biomaterials and nanobiomaterials.

Selected Contents

Overview of Biomaterials. Basics of HumanBiology. Degradation and Corrosion ofBiomaterials. Failure and Tribology ofBiomaterials. Nanoscale Phenomena. MetallicBiomaterials. Ceramic Biomaterials. PolymericBiomaterials. Composite Biomaterials.Nanobiomaterials for Tissue Engineering.Glossary. Exercises. References.

Catalog no. 47817, June 2010, 372 pp.ISBN: 978-1-4200-4781-3, $99.95 / £69.99



11For more information and complete contents, visit www.crcpress.com


BiologicalPerformance of MaterialsFundamentals ofBiocompatibility,Fourth EditionJonathan BlackClemson University (ProfessorEmeritus), South Carolina, USA

Biological Performance of Materials focuses onprinciples of biological performance at a funda-mental level, analyzing interactions betweenorganisms and nonliving materials used in med-ical devices. The book is divided into three sec-tions: the material response to biological sys-tems, host response to biomaterials, and testmethods for determining biological response invitro as well as in animal models and clinical set-tings. Subsections summarize the physical prop-erties of commonly used metallic, polymeric,and ceramic biomaterials and provide a guide tounderstanding the clinical performance ofimplanted biomaterials.

Catalog no. 3959, December 2005, 520 pp.ISBN: 978-0-8493-3959-2, $115.95 / £73.99

Coming Soon!

Optical ImagingTechniques inCell BiologySecond EditionEdited by

Guy CoxUniversity of Sydney, New South Wales, Australia

A reference on optical imaging techniques, thisbook covers the field, from the basics of the opti-cal microscope to highly advanced techniquessuch as Forster resonant energy transfer (FRET)and fluorescence lifetime imaging microscopy(FLIM), in a uniform style and format. It providesan understanding of the underlying principles, soreaders can understand the benefits and limita-tions of each technique described. Topics cov-ered include optical contrasting techniques, fluo-rescence and fluorescence microscopes, three-dimensional imaging, the confocal microscope,non-linear microscopy, advanced fluorescencetechniques, and breaking the diffraction limit.

Catalog no. K12150, June 2012, c. 320 pp.ISBN: 978-1-4398-4825-8, $149.95 / £95.00Also available as eBook

BiomaterialsFabrication andProcessingHandbookEdited by

Paul K. ChuCity University of Hong Kong,Kowloon

Xuanyong LiuShanghai Institute of Ceramics, China

Comprehensive in scope, this book focuses on avariety of production and processing aspects ofbiomaterials. It discusses how scaffolds are usedin tissue engineering and describes commonimplant materials, such as hard tissue, bloodcontacting, and soft tissue. The book also exam-ines the important role nanotechnology plays inthe preparation of drugs, protein delivery, tissueengineering, cardiovascular biomaterials, hardtissue replacements, biosensors, and bio-MEMS.With contributions from renowned internationalexperts and extensive reference lists in eachchapter, this book provides detailed, practicalguidance on producing biomaterials andemploying them in biomedicine.

Catalog no. 7973, March 2008, 720 pp.ISBN: 978-0-8493-7973-4, $169.95 / £108.00Also available as eBook

Porous MediaApplications inBiological Systemsand BiotechnologyEdited by

Kambiz VafaiUniversity of California, Riverside, USA

This volume explores innovative approaches toeffectively apply existing porous media technolo-gies to biomedical applications. In each peer-reviewed chapter, world-class scientists and engi-neers address significant problems and discussexciting research in biological systems. They covervarious transport processes, mechanical behavior,and material properties of biological tissues from aporous media point of view. The book also pres-ents pertinent aspects of experimental work andnumerical techniques and discusses the modelingof several phenomena, including flow changes incerebral aneurysms, biomass growth, marine sys-tems, and tissue homeostasis and repair.

Catalog no. 65416, August 2010, 632 pp.ISBN: 978-1-4200-6541-1, $149.95 / £95.00Also available as eBook







Fundamentalsof BiofilmResearchZbigniew LewandowskiMontana State University,Bozeman, USA

Haluk BeyenalWashington State University, Pullman, USA

“... describes the fundamentals of biofilm researchfrom a bioengineering perspective in an easy-to-read and straightforward manner. This is aninteresting, logical and well-written book . . . acomprehensive and well rounded book which iscomplementary to other literature in this area.”

—Microbiology Today

This book discusses compatible tools and meas-urements that can be used to conduct biofilmstudies and interpret their results in a consistentmanner. The authors introduce conceptual,physical, computational, and virtual tools tohelp achieve reproducible results, align researchspecific parameters, and ease difficulties in com-munication.

Catalog no. 3541, May 2007, 480 pp.ISBN: 978-0-8493-3541-9, $149.95 / £96.00

Biomaterials for MEMSEdited by

Mu ChiaoUniversity of British Columbia,Vancouver, Canada

J.C. ChiaoUniversity of Texas at Arlington, USA

This book serves as a guide for practicing engi-neers, researchers and students interested inMEMS devices and biomaterials and biomedicalapplications. It is also suitable for engineers andresearchers interested in MEMS and its applica-tions but who do not have the necessary back-ground in biomaterials. The book highlightsimportant features and issues of biomaterialsthat have been used in MEMS and biomedicalareas, including the fabrication of devices usingbiomaterials, biocompatible coatings and issues,thin-film biomaterials and MEMS for tissue engi-neering, and applications involving MEMS andbiomaterials.

Catalog no. N10421, March 2011, 292 pp. ISBN: 978-981-4241-46-5, $149.95 / £95.00Also available as an eBook

BiomaterialsEdited by

Joyce Y. WongBoston University,Massachusetts, USA

Joseph D. BronzinoTrinity College, Hartford,Connecticut, USA

To make sure that medical devices placed insidethe body are safe, reliable, economical, and bio-logically and physiologically compatible, the mod-ern biomedical engineer must have a broadknowledge of currently available materials and theproperties that affect their in-service performance.In chapters drawn from the third edition of thebestselling Biomedical Engineering Handbook,Biomaterials surveys the wide variety of biomate-rials in use as well as materials resulting from novelmicro- and nanoscale technologies. In addition tomaterial from the Handbook, nearly one-third ofthis sharply focused work is new.


TissueEngineeringEdited by

John P. FisherUniversity of Maryland, College Park, USA

Antonios G. MikosRice University, Houston, exas, USA

Joseph D. BronzinoTrinity College, Hartford, Connecticut, USA

The ability to engineer biocompatible tissue is thehallmark of modern biomedical engineering, inte-grating all aspects of every sub-discipline in thefield. Bringing in a diverse group of internationalcontributors with backgrounds in academia, clini-cal medicine, and industry, this book surveysadvances in this relatively young area. Divided intothree sections, it discusses the fundamental con-cepts of tissue engineering, enabling technologies,and tissue engineering applications. It examinesstrategies that incorporate scaffolds, nanocompos-ites, bioreactors, drug delivery systems, and genetherapy techniques that are being applied inregenerative medicine.

Catalog no. 9026, May 2007, 600 pp.ISBN: 978-0-8493-9026-5, $104.95 / £66.99Also available as eBook





13



New!

Handbook ofIntelligentScaffold for TissueEngineering andRegenerativeMedicineEdited byGilson KhangChonbuk National University, Jeonju, North Korea

Providing detailed knowledge about fullerenenanowhiskers and the related low-dimensionalfullerene nanomaterials, this book introducestubular nanofibers made of fullerenes, fullerenenanotubes, as well as the single crystalline thin filmmade of C60, called fullerene nanosheet. It is thefirst publication featuring the fullerenenanowhiskers made of C60, C70, and C60 derivatives.It demonstrates the synthetic method (liquid–liq-uid interfacial precipitation method) and the phys-ical and chemical properties such as electrical,mechanical, optical, magnetic, thermodynamic,and surface properties for the fullerenenanowhiskers, including their electronic deviceapplication.

Catalog no. N10464, February 2012, 974 pp.ISBN: 978-981-4267-85-4, $499.95 / £318.00Also available as eBook

Biointegrationof MedicalImplantMaterialsScience and DesignEdited by

Chandra P. SharmaSree Chitra Tirunal Institute for Medical Sciences andTechnology, India

This book provides a review of research intomaterial and tissue interaction and integration.The first section discusses soft tissue biointegra-tion with chapters on the biocompatibility ofengineered stem cells, corneal tissue engineer-ing, and vascular grafts. The second sectionreviews techniques in drug delivery, includinginorganic nanoparticles for targeted drug deliv-ery and alginate-based drug delivery devices.The third section covers design considerations,exploring biocompatibility of materials and itsrelevance to drug delivery and tissue engineer-ing, mechanisms of failure of medical implantsduring long-term use, and rapid prototyping inbiomedical engineering.

Catalog no. N10181, August 2010, 384 pp.ISBN: 978-1-4398-3064-2, $229.95 / £146.00

RegenerativeMedicine andBiomaterials forthe Repair ofConnectiveTissuesEdited by

Charles Archer and Jim RalphsCardiff University, UK

Regenerative medicine for the repair of connectivetissues is a fast moving field that generates a lot ofinterest. The biomaterials and biomechanics forsoft tissue repair has been under-represented inthe past; particularly the natural connectionbetween cartilage, tendons, and ligaments is oftennot made. This book addresses the gap by explor-ing the natural association of cartilage, tendons,and ligaments to provide a review of the differentstructures and biomechanics and to provide a dis-cussion of practical techniques and biomaterialsthat are being used to repair connective tissues.

Catalog no. N10011, February 2010, 600 pp.ISBN: 978-1-4398-0110-9, $249.95 / £159.00

Biomaterialsand TissueEngineering inUrologyEdited by

John DenstedtUniversity of Western Ontario.Canada

Anthony AtalaWake Forest University, Winston-Salem, North Carolina, USA

An invaluable resource for clinicians as well as forresearchers in materials and biomedical devices,this text summarizes research on the use of biomaterials and tissue engineering in the treat-ment of urological disorders. The book reviews thefundamentals and then discusses advances in bio-materials and the design of urological devices suchas metal ureteral stents, self-lubricating cathetermaterials, and penile implants. The final sectionaddresses urological tissue engineering, coveringartificial and natural biomaterials, nanotechnolo-gy, and placental stem cells used for the regenera-tion of urological tissue and organs.

Catalog no. N10041, June 2009, 500 pp.ISBN: 978-1-4398-0177-2, $247.95 / £150.00






Design & Rehabilitation

New!

Assistive Technology AssessmentHandbookEdited by

Stefano FedericiUniversity of Perugia, Italy

Marcia J. SchererInstitute for Matching Person & Technology, Webster, New York, USA

Assistive Technology Assessment Handbook fillsthe need for a reference that helps assistive tech-nology experts perform assessments that moreeffectively connect the person and the technol-ogy. Emphasizing the well-being of the individ-ual with a disability, the book proposes an idealmodel of the assistive technology assessmentprocess and outlines how this model can beapplied in practice internationally.Organized into three parts, the handbook:

• Gives readers a toolkit for performing assessments

• Describes the roles of the assessment teammembers, among them the new professionof the psychotechnologist, who is skilled inunderstanding individuals and their psychosocial and technological needs andpreferences

• Reviews cutting-edge technologies forrehabilitation and independent living,

including brain–computer interfaces andmicroswitches

The book synthesizes information scatteredthroughout the international literature, focusingon aspects that are particularly representative orinnovative. It also addresses the challengesposed by the variety of health and social caresystems and the different ways that individualswho need aid are defined—are they users,patients, clients, or consumers, and how doesthat affect the assessment?Edited by Stefano Federici and Marcia J. Scherer,internationally renowned leaders in the field ofassistive technology assessment, this cross-cul-tural handbook includes contributions fromleading experts across five continents. Guidingreaders in matching the person and the appro-priate assistive technology, it offers a frameworkfor future practice and research.

Catalog no. K11756, March 2012, 484 pp.ISBN: 978-1-4398-3865-5, $139.95 / £82.00Also available a eBook

“These colleagues are at the forefront of workwithin the field of assistive technology and havepioneered much of the current thinking resultingin both the delivery of services to individuals andtransformational research. ... This edited volumeincludes contributions from five continents andreinforces the global approach to responding tothe needs of individuals and in some cases com-munities requiring support and intervention. ...this book in the way it has brought together sucha wide range of committed individuals has as itsunderpinning philosophy a commitment to listen-ing to and responding positively to the voice ofthe individual participant.”

—from the Foreword by Dave J. Muller, Editor-in-Chief, Disability and Rehabilitation

Selected Contents

Section I: The Assistive TechnologyAssessment Model and Basic Definitions:Assessing Individual Functioning and Disability.Measuring Individual Functioning. Measuring theAssistive Technology Match. The Assessment ofthe Environments of AT Use: Accessibility,Sustainability, and Universal Design. Measuringthe Impact of AT on Family Caregivers. SectionII: Assessment Professionals: Working on theMultidisciplinary Team: The Cognitive Therapist.The Special Educator. The Psychologist. ThePsychotechnologist: A New Profession in theAssistive Technology Assessment. TheOptometrist. The Occupational Therapist:Enabling Activities and Participation UsingAssistive Technology. Pediatric Specialists inAssistive Solutions. The Geriatrician. Role ofSpeech–Language Pathologists in AssistiveTechnology Assessments. Section III: AssistiveTechnology Devices and Services: SystemicUser Experience. Web Solutions for Rehabilitationand Daily Life. Brain–Computer Interfaces: TheNew Landscape in Assistive Technology. ...


15



Usability Testing of Medical DevicesMichael Wiklund, Jonathan Kendler, and Allison Yale StrochlicWiklund Research Design, Inc., Concord, Massachusetts, USA

better suited to evaluating consumer, andbusiness products, for example, that pose different demands

• Presents the information in a highly visualformat, making it appealing to the audiencecomprised mostly marketers, engineers, andregulatory affairs specialists

• Draws on the experience of a widely recognized authority in the medical industryon usability testing of medical devices

• Includes an accompanying CD that containsvideos of mock usability tests, demonstratingthe techniques described in the book

• Supplies sample test plans for practitionerswho would prefer to "plug" content into anauthoritative template

Selected Contents

IntroductionRisk Management and Usability TestingThe Commercial ImperativeTesting CostsAnatomy of a Usability TestTypes of TestsWriting a Test PlanChoosing a Participant Sample and RecruitingParticipantsTest EnvironmentsAdding RealismSelecting TasksConducting the TestInteracting with Test ParticipantsDocumenting the TestAnalyzing Test DataReporting ResultsValidation TestingResourcesIndex

Catalog no. K10595, December 2010, 412 pp.ISBN: 978-1-4398-1183-2, $72.95 / £45.99Also available as an eBook

“A comprehensive guide to Human Factors testingfor medical device development. This book is anexcellent resource to guide your human factorsdecision making throughout the developmentprocess. A must have, as today's medical devicesbecome more and more targeted to users withoutformal medical training.”

—Dean Kamen, founder of DEKA Research & Development

“I highly recommend this text for anyone whosework involves any aspect of human factors andmedical devices. It is an excellent, easy-to-read,and comprehensive guide on usability testing andmedical devices. It will be an extremely valuableresource for ECRI Institute's future evaluationefforts.”

—James P. Keller, Vice President, Health TechnologyEvaluation and Safety, ECRI Institute

“Today, usability testing of medical devices is aregulatory and quality assurance imperative.Personally, I believe usability is a significant,under-recognized patient safety issue. This bookcomplements the latest standards with plenty ofdown-to-earth, ‘how-to’ advice for test managers.”

—Doug Hansell, M.D., Chief Medical Officer & Vice President, Covidien,

Respiratory & Monitoring Solutions

Informative, practical, and engaging, this hand-book covers how to conduct usability tests ofmedical devices. Recognizing that the intendedreaders are busy and disinclined to read lengthytextbooks, this book has been carefully designedto be concise and visual, allowing readers tojump from one section to another as needed.The book provides a general understanding ofusability testing and reviews key concepts. Ithighlights the challenges of validating that pro-tects against dangerous errors that could lead topatient injury and death.

• Provides a singular source of guidance onconducting a usability test in an industry-specific manner, as opposed to a manner




Ergonomics forRehabilitationProfessionalsEdited by

Shrawan KumarUniversity of North Texas, Fort Worth, USA

Designed to meet the diverse needs of thera-pists, this book presents a new approach torehabilitation that integrates ergonomics con-cepts to address the wide range of problemscommonly encountered by professionals. Itaddresses general concepts such as anthropom-etry and tissue mechanics and examines wholebody biomechanics, demonstrating theergonomic effects of physiological and biome-chanical factors. The author also focuses onregional biomechanics, explaining the rationalefor ergonomic intervention, and discusses theergonomic paradigm in rehabilitation, includingthe use of physical demands analysis.

Catalog no. 8146, April 2009, 640 pp.ISBN: 978-0-8493-8146-1, $107.95 / £69.99Also available as eBook

Second Editionof a Bestseller!

Design ofBiomedicalDevices andSystemsSecond EditionPaul H. KingVanderbilt University, Nashville, Tennessee, USA

Richard C. FriesBaxter Healthcare, Round Lake, Illinois, USA

The second edition of a bestseller, this book pro-vides a comprehensive overview of biomedicaldevice and system design—including topicsrelated to databases, process analysis, anddevice improvement—from a strong design perspective. It covers all aspects of design thatmust be considered for complex biomedicalprojects. Updated to reflect advances in thefield, this second edition features information ondevice definition and reliability, as well as testingand hardware verification. The book includescase studies.


DesigningUsability intoMedicalProductsMichael E. WiklundWiklund Research & Design, Inc.,Concord, Massachusetts, USA

Stephen B. WilcoxDesign Science, Philadelphia,Pennsylvania, USA

“This book should be on the shelf of anyoneinvolved in the development of medical products.Today devices are getting more and more complexwhile caregivers as a whole are much less experi-enced. User centered interface design has to makeup the difference and this book gives you a plan.”

—Nicholas Barker, Vice President - Design, Datascope Corp

Advocating a user-centered approach to medicaltechnology design, this book covers the essentialprocesses and specific techniques necessary toproduce safe, effective, usable, and appealingmedical systems and products.

Catalog no. 2843, February 2005, 376 pp.ISBN: 978-0-8493-2843-5, $139.95 / £89.00Also available as eBook

PaediatricRehabilitationEngineeringFrom Disability to PossibilityEdited by

Tom ChauBloorview Kids Rehab, Toronto, Canada

Jillian FairleyWritten by international experts, PaediatricRehabilitation Engineering provides a synopsisof advances in research in pediatric rehabilitationengineering. Offering a single comprehensiveresource on current findings, each chapter detailsa particular area of technology or those develop-ments of particular clinical relevance to pediatricrehabilitation. Each chapter also includes a con-ceptual description of the technology or underly-ing scientific principles, followed by a synthesis ofrelevant literature, research advances, selectedclinical case studies (where applicable), and per-spectives for future directions.

Catalog no. K10416, December 2010, 366 pp.ISBN: 978-1-4398-0842-9, $145.95 / £93.00





17

BioMEMS


Coming Soon!

Introduction to BioMEMSAlbert FolchUniversity of Washington,Seattle, USA

“The field has been waitingfor a true textbook that pro-vides a practical, historical, authoritative andcomprehensive introduction to bioMEMS. It hasfinally arrived, courtesy of Albert Folch, completewith PowerPoint lectures and thoughtful home-work questions. I highly recommend it.”

—David J. Beebe, University of Wisconsin–Madison

“A comprehensive, colorful textbook on theimportant field of bioMEMS. I will definitely recommend to my students!”

—Albert van den Berg, University of Twente

“Dr. Folch’s book is a monumental achievementwhich brings an authoritative and comprehensiveaccount to the rapidly growing, multidisciplinaryfield of bioMEMS. Many working scientists andengineers as well as students will find this bookfascinating.”

—Mehmet Toner, Helen Andrus Benedict Professor ofBioengineering, Harvard Medical School

“This book successfully integrates microfabrica-tion and the physics of microfluidics with numer-ous biological applications. It provides a visualfeast of images that lead to a comprehensiveunderstanding of many complex concepts.Applications presented range from biomoleculesto cells, tissues, and organisms, and are presentedin clear, logical steps. It serves as an outstandingtext for advanced undergraduates and graduatestudents, as well as an excellent review forresearchers who are new to the field.”

—Dr. Fawwaz Habbal, Harvard University

“An excellent, easy-to-ready textbook for everyonewho wants to obtain a fundamental understand-ing of bioMEMS technology and get inspiredabout micro/nano bioengineering.”

—Professor Nikos Chronis, University of Michigan

“With extensive citations of the current literature,explanations that really put the technology incontext, clear enunciation of the motivations forminiaturization, and historical perspective, theauthor has made the material very accessible andclear … I definitely recommend this textbook forbioengineering students.”—Professor Karen C. Cheung, University of British Columbia

Catalog no. K10966, May 2012, c. 528 pp.ISBN: 978-1-4398-1839-8, $89.95 / £57.99Also available as eBook

Third Edition of a Bestseller!

From MEMS toBio-MEMS andBio-NEMSManufacturingTechniques andApplicationsMarc J. MadouUniversity of California, Irvine, USA

The third volume in Fundamentals of Microfabrica-tion and Nanotechnology, Third Edition, Three-Volume Set, this book details manufacturing tech-niques applicable to bio-nanotechnology. Afterreviewing MEMS techniques, materials, and mod-eling, the author covers nanofabrication, geneti-cally engineered proteins, artificial cells, nano-chemistry, and self-assembly. He also discussesscaling laws in MEMS and NEMS, actuators, flu-idics, and power and brains in miniature devices.Coverage includes various MEMS and NEMSapplications.The book discusses top-down and bottom-upmanufacturing methods and explains how to usenature as a guide. It provides a better understand-ing of how to match different manufacturingoptions with a given application that students canuse to identify additional killer MEMS and NEMSapplications. Fully illustrated in color, the text con-tains end-of-chapter problems, worked examples,extensive references for further reading, and anextensive glossary of terms.Solutions manual, PowerPoint® lecture slides, and electronic

figures available upon qualifying course adoption

Selected Contents

From Traditional Manufacturing toNanotechnology: Nonlithography-Based(Traditional) and Lithography-Based(Nontraditional) Manufacturing Compared.Nature as an Engineering Guide: Biomimetics.Nanotechnology: Top-Down and Bottom-UpManufacturing Approaches Compared. ...

Catalog no. 5516X, June 2011, 650 pp.ISBN: 978-1-4200-5516-0, $99.95 / £63.99Also available as eBook

Also Available as Part of a Set

Fundamentals of Microfabricationand NanotechnologyThird Edition, Three-Volume SetMarc J. MadouUniversity of California, Irvine, USA

Catalog no. 3180, August 2011, 1992 pp.ISBN: 978-0-8493-3180-0, $249.95 / £159.00





BioMEMS

BiomedicalMicrosystemsEllis MengUniversity of Southern California,Los Angeles, USA

Biomedical Microsystemscovers the fundamentals ofminiaturization, biomateri-als, microfabrication, and nanotechnology, alongwith relevant applications.Written by an active researcher who was recentlynamed one of Technology Review’s Young InnovatorsUnder 35, the book begins with an introduction tothe benefits of miniaturization. It then introducesmaterials, fabrication technology, and the neces-sary components of all bioMEMS. The author alsocovers fundamental principles and buildingblocks, including microfluidic concepts, lab-on-a-chip systems, and sensing and detection methods.The final chapters explore several important appli-cations of bioMEMS, such as microdialysis,catheter-based sensors, MEMS implants, neuralprobes, and tissue engineering.

Features

• Presents a rigorous, in-depth treatment ofbioMEMS materials, methods, processes, andconcepts

• Emphasizes practical knowledge useful forapplication to real-world problems

• Describes research and commercializedbioMEMS devices as well as emerging applications

• Includes detailed examples, laboratory exercises,and a variety of homework problems

• Contains numerous illustrations of concepts,processes, and devices

For readers with a limited background in MEMSand bioMEMS, this book provides a practical intro-duction to the technology used to make thesedevices, the principles that govern their operation,and examples of their application. It offers a start-ing point for understanding advanced topics andencourages readers to begin to formulate theirown ideas about the design of novel bioMEMS.


Selected Contents

Introduction. BioMEMS Materials.Microfabrication Methods and Processes forBioMEMS. Microfluidics. ...

Catalog no. 51229, September 2010, 408 pp.ISBN: 978-1-4200-5122-3, $94.95 / £59.99Also available as an eBook

BioMEMSScience andEngineeringPerspectivesSimona Badilescu and MuthukumaranPackirisamyConcordia University, Montreal, Canada

Because BioMEMS researchand development require the input of expertswho use different technical languages and comefrom varying disciplines and backgrounds, scien-tists and students can avoid potential difficultiesin communication and understanding only ifthey possess a skill set and understanding thatenables them to work at the interface of engi-neering and biosciences.Keeping this duality in mind throughout,BioMEMS: Science and EngineeringPerspectives supports and expedites the multi-disciplinary learning involved in the develop-ment of biomicrosystems. Divided into ninechapters, it starts with a balanced introductionof biological, engineering, application, andcommercialization aspects of the field. With afocus on molecules of biological interest, thebook explores the building blocks of cells andviruses, as well as molecules that form the self-assembled monolayers (SAMs), linkers, andhydrogels used for making different surfaces bio-compatible through functionalization. The book also discusses:

• Different materials and platforms used todevelop biomicrosystems

• Various biological entities and pathogens (inascending order of complexity)

• The multidisciplinary aspects of engineeringbioactive surfaces

• Engineering perspectives, including methods ofmanufacturing bioactive surfaces and devices

• Microfluidics modeling and experimentation

• Device-level implementation of BioMEMSconcepts for different applications

Because BioMEMS is an application-driven field,the book also highlights the concepts of lab-on-a-chip (LOC) and micro total analysis system(�TAS), along with their pertinence to emergingpoint-of-care (POC) and point-of-need (PON)applications.


Catalog no. K10877, April 2011, 368 pp.ISBN: 978-1-4398-1699-8, $99.95 / £63.99Also available as an eBook



19

Solid & Fluid Mechanics


New!

Biofluid MechanicsThe Human Circulation, Second EditionKrishnan B. ChandranUniversity of Iowa, Iowa City, USA

Ajit P. YoganathanGeorgia Institute of Technology, Atlanta, USA

Stanley E. RittgersUniversity of Akron, Ohio, USA

“... the book provides a good platform in fluidmechanics prior to progressing to the physiologi-cal applications which make it an appropriatetextbook for BME students.”

—Professor Tim McGloughlin, Centre for AppliedBiomedical Engineering Research and Department of

Mechanical Aeronautical and Biomedical Engineering,University of Limerick

Designed for senior undergraduate or first-yeargraduate students in biomedical engineering,Biofluid Mechanics: The Human Circulation,Second Edition teaches students how fluidmechanics is applied to the study of the humancirculatory system. Reflecting changes in the fieldsince the publication of its predecessor, this sec-ond edition has been extensively revised andupdated.

New to the Second Edition

• Improved figures and additional examples

• More problems at the end of each chapter

• A chapter on the computational fluid dynamic analysis of the human circulation,which reflects the rapidly increasing use ofcomputational simulations in research andclinical arenas

Drawing on the authors’ experience teachingcourses on cardiovascular fluid mechanics, thebook begins with introductory material on fluidand solid mechanics as well as a review of car-diovascular physiology pertinent to the topicscovered in subsequent chapters. The authorsthen discuss fluid mechanics in the human cir-culation, primarily applied to blood flow at thearterial level. They also cover vascular implantsand measurements in the cardiovascular system.The text includes end-of-chapter references andproblems as well as numerous figures through-out that have been selected from the publica-tions of many eminent researchers.

• Provides a classroom-tested textbook for afirst course on fluid mechanics in human circulation, focusing on the heart and majorarteries

• Reviews fluid and solid mechanics and normalcardiovascular physiology

• Explains how to model steady and unsteadyflows

• Evaluates the design and development ofartificial heart valves, stent implants, and vascular grafts

• Describes various considerations and approachesinvolved in the computational modeling of cardiovascular diseases and therapies

• Includes end-of-chapter references and problems as well as numerous figuresthroughout that have been selected from thepublications of many eminent researchers


Selected Contents

Fluid and Solid Mechanics and CardiovascularPhysiologyFundamentals of Fluid Mechanics. Introductionto Solid Mechanics. Cardiovascular Physiology.Biomechanics of the Human CirculationRheology of Blood and Vascular Mechanics.Static and Steady Flow Models. Unsteady Flowand Nonuniform Geometric Models. NativeHeart Valves. Cardiovascular Implants, BiomechanicalMeasurements, and ComputationalSimulationsProsthetic Heart Valve Dynamics. VascularTherapeutic Techniques. Fluid DynamicMeasurement Techniques. Computational FluidDynamic Analysis of the Human Circulation.Index

Catalog no. K12006, March 2012, 451 pp.ISBN: 978-1-4398-4516-5, $104.95 / £66.99Also available as an eBook




Mechanobiology HandbookEdited by

Jiro NagatomiClemson University, South Carolina, USA

Mechanobiology—the study of the effects ofmechanical environments on the biologicalprocesses of cells—has evolved from traditionalbiomechanics via the incorporation of strong ele-ments of molecular and cell biology. Currently, abroad range of organ systems are being studiedby surgeons, physicians, basic scientists, and engi-neers. These mechanobiologists aim to create newtherapies and further biological understanding byquantifying the mechanical environment of cellsand the molecular mechanisms of mechanicallyinduced pathological conditions. To achieve these goals, investigators must befamiliar with both the basic concepts of mechan-ics and the modern tools of cellular/molecularbiology. Unfortunately, current literature containsnumerous studies that misuse standard mechani-cal estimations and terminology, or fail to imple-ment appropriate molecular analyses. Therefore,the Mechanobiology Handbook not only pres-ents cutting-edge research findings across variousfields and organ systems, but also provides the ele-mentary chapters on mechanics and molecularanalysis techniques to encourage cross-fieldunderstanding and appropriate planning. Aided by the continuous advancement of researchtools in both mechanics and biology more sophis-ticated experiments and analyses are possible,thus fueling the growth of the field of mechanobi-ology. Considering the complexity of the mechan-ics and the biology of the human body, most ofthe world of biomechanics remains to be studied.Since the field is still developing, theMechanobiology Handbook does not force oneunified theory, but brings out many different view-points and approaches to stimulate furtherresearch questions.

• Presents research data and viewpoints fromdiverse fields of mechanobiology

• Includes background information in mechanicsand cell biology

• Explores application areas such as tissue engineering

Selected Contents

Basic Science Tools for MechanobiologyResearchAn Introductory Guide to Solid Mechanics.Fluid Mechanics. Molecular Analysis inMechanobiology.

Literature Review of Mechanobiology:Research Findings and Theories:

Cardiovascular SystemsEffects of Endovascular Intervention on VascularSmooth Muscle Cell Function. Effects ofPressure on Vascular Smooth Muscle Cells.Mechanobiology of Heart Valves.Mechanobiology of Cardiac Fibroblasts. ...

Musculoskeletal SystemsSkeletal Mechanobiology. Mechanical Control of Bone Remodeling. Cartilage Mechanobiology.Cell Mechanobiology: The Forces Applied toCells and Generated by Cells.

Other Organ SystemsPulmonary Vascular Mechanobiology. LungEchanobiology. Mechanical Signaling in theUrinary Bladder. Mechanobiology of BladderUrothelial Cells. ...

Frontiers of MechanobiologyMechanostimulation in Bone and TendonTissue Engineering. Mechanobiology in theStem Cell Niche: Integrating Physical andChemical Regulation of Differentiation.Mesenchymal Stem Cell Mechanobiology. The Use of Microfluidic Technology inMechanobiology Research. ...

Index

Catalog no. 91212, March 2011, 563 pp.ISBN: 978-1-4200-9121-2, $169.95 / £109.00Also available as an eBook


21



Biomechanics of the Upper LimbsMechanics, Modeling and Musculoskeletal Injuries,Second EditionAndris FreivaldsPennsylvania State University, University Park, USA

Despite a spike in the number of work-related musculoskeletal disorders(WRMSDs) in the upper limbs due to a sharp increase in the amount ofcomputer-related jobs, few books have focused exclusively on WRMSDs,until now.

Biomechanics of the Upper Limbs: Mechanics,Modeling and Musculoskeletal Injuries, SecondEdition offers vital information and tools toimprove analysis of external forces and theireffects on the human body. This can helpergonomists better understand job stressors andthe role they play in the development of disor-ders, enabling them to modify the work envi-ronment and educate practitioners to bettercontrol harmful situations.

Using the author’s medical and engineeringexpertise to distill essential subject matter anduseful technical data, this comprehensive textexplores:

• Biomechanics of the upper limbs and themotor control system

• The structure and physiology of the humanmusculoskeletal and neuromuscular systems

• Recent research findings and solutions to various ergonomic problems

• Models of various components of the neuromuscular systems, as well as larger systems in the upper limbs

• Risk factors for disorders and tools used toidentify their causes

Designed as a textbook for a typical semester-long graduate-level engineering or kinesiologycourse, this book includes a link to an ancillarywebsite that offers materials such as PowerPoint®

slides, sample exams, and an instructor's manu-al with complete solutions. It also serves as apractical, current, engineering-oriented resourcefor researchers, industrial ergonomists, industrialhygienists, and medical professionals whorequire supplementary material.

Catalog no. 91190, February 2011, 564 pp.ISBN: 978-1-4200-9119-9, $119.95 / £76.99Also available as eBook

Selected Contents

Introduction to BiomechanicsWhat Is Biomechanics? Basic Concepts.Coordinate Systems. Force Vector Algebra. StaticEquilibrium. Anthropometry and Center of MassDetermination. Friction. Dynamics.Structure of the Musculoskeletal SystemGross Overview of Movements. Skeletal System.Mechanical Properties of Bone. Soft ConnectiveTissue. Joints.Neuromuscular Physiology and Motor ControlIntroduction to Musculature. Structure of Muscle.Basic Cell Physiology. Nervous System. ...Modeling of Muscle MechanicsLaplace Transforms and Transfer Functions.Viscoelastic Theory. Hill’s Muscle Models.Frequency Analysis. ...Models of the Upper LimbsAnatomy of the Hand and Wrist. Static Tendon-Pulley Models. ...Musculoskeletal Disorders and Risk FactorsExtent of the Problem. Common MusculoskeletalDisorders and Their Etiology. Medical Diagnosisand Treatment of MSDs. ...InstrumentationWrist- and Finger-Motion Measurements. Pressure-and Force-Distribution Measurements. ...Job and Worksite AnalysisThe Need for Job Analysis. Reliability and Validityof Assessment Tools. Initial Identification ofMusculoskeletal Injury Problems. ...Hand ToolsGeneral Biomechanical Considerations of Tools.Handles for Single-Handled Tools. Handles forTwo-Handled Tools. ...The Office Environment General Musculoskeletal Problems. SeatedWorkplace. Keyboard. Mouse and Other Cursor-Positioning Devices. Notebooks and HandheldPCs. Interventions for Office Work.




Microfluidics and Nanofluidics HandbookTwo-Volume SetEdited by

Sushanta K. MitraUniversity of Alberta, Edmonton, Canada

Suman ChakrabortyIndian Institute of Technology (IIT), Kharagpur, India

The Microfluidics and Nanofluidics Handbook:Two-Volume Set comprehensively captures thecross-disciplinary breadth of micro- and nanoflu-idics, which encompass the biological sciences,chemistry, physics and engineering applications.To fill the knowledge gap between engineeringand the basic sciences, the editors pulled togetherkey individuals, well known in their respectiveareas, to author chapters that help graduate students, scientists, and practicing engineersunderstand the overall area of microfluidics andnanofluidics.

• Discusses basic microbiology and chemistryrelated to microfluidics

• Explains fabrication techniques

• Emphasizes applications of microfluidics inthe energy sector

• Describes micro-fuel cells and lab-on-a-chip

• Presents example tables, graphs, and equationsCovering physics and transport phenomena alongwith life sciences and related applications, VolumeOne: Chemistry, Physics, and Life Science Principlesprovides readers with the fundamental sciencebackground that are required for the study ofmicrofluidics and nanofluidics. Volume Two:Fabrication, Implementation, and Applications focuseson topics related to experimental and numericalmethods, followed by chapters on fabricationsand other applications, ranging from aerospace tobiological systems. Both volumes include as muchinterdisciplinary knowledge as possible to reflectthe inherent nature of this area, making themvaluable to students and practitioners.

Buy the Set and Save

Catalog no. K10859, September 2011, 1766 pp.ISBN: 978-1-4398-1671-4, $279.95 / £178.00Also available as an eBook

Microfluidics andNanofluidics HandbookChemistry, Physics, and Life Science Principles

Selected Contents

Physics and Transport Phenomena: AnOverview of Continuum Description of Fluid Flowand Transport Processes. Microscale Gas FlowDynamics and Molecular Models for Gas Flowand Heat Transfer. ... Life Sciences and Related Applications:Biotechnology for Bioengineers. CellularBiomicrofluidics. Cell Lysis Techniques in Lab-on-a-Chip Technology. ...


Microfluidics andNanofluidics HandbookFabrication, Implementation, and Applications

Selected Contents

Experimental and Numerical Methods: Image-Based Photonic Techniques for Microfluidics.Recent Developments in Microparticle ImageVelocimetry. ...Fabrication and Other Applications: SU-8Photolithography and Its Impact on Microfluidics.System Integration in Microfluidics. FluidicInterconnects for Microfluidics: Chip to Chip andWorld to Chip. Micro Total Analysis Systems.Microparticle and Nanoparticle Manipulation.Optoelectric Particle Manipulation. MicrofluidicParticle Counting Sensors. Magnetic-Particle-Based Microfluidics. ...





23



Principles ofBiomechanicsRonald L. HustonUniversity of Cincinnati, Ohio, USA

Presenting the fundamental concepts that arerequired for further research in this field, thisvolume emphasizes biodynamic modeling andhuman body models. Beginning with a reviewof gross human anatomy and a summary ofbasic terminology, it describes various methodsof analysis, including elementary mathematics,elementary mechanics, and the mechanics ofmaterials. Later chapters discuss the modeling ofbiosystems, tissue biomechanics, biodynamics,kinematics, kinetics, and the inertial propertiesof human body models. The book concludeswith a review of sample applications of biody-namic models in activities such as lifting,maneuvering in space, walking, and swimming.

• Focuses on fundamental principles in biosystems and the human body

• Discusses biosystem modeling and elementarymechanics

• Includes examples and problems to clarifymaterial

• Provides the basis for advanced study,research, and practice in biomechanics

Selected Contents

Introduction. Review of Human Anatomy andSome Basic Terminology. Methods of Analysis I:Review of Vectors, Dyadics, Matrices, andDeterminants. Methods of Analysis II: Forcesand Force Systems. Methods of Analysis III:Mechanics of Materials. Methods of Analysis IV:Modeling of Biosystems. Tissue Biomechanics.Kinematical Preliminaries: FundamentalEquations. Kinematic Preliminaries: Inertia ForceConsiderations. Human Body Inertia Properties.Kinematics of Human Body Models. Kinetics ofHuman Body Models. Dynamics of HumanBody Models. Numerical Methods. Simulationsand Applications. Appendix A. AnthropometricData Tables. Glossary. Bibliography. Index.

Catalog no. DK494X, December 2008, 442 pp.ISBN: 978-0-8493-3494-8, $115.95 / £73.99Also available a eBook

Introduction toEngineeringMechanicsA ContinuumApproachJenn Stroud RossmannLafayette College, Easton,Pennsylvania, USA

Clive L. DymHarvey Mudd College,Claremont, California, USA

“This book is a welcome addition to the family of resources for undergraduates majoring inmechanical, aerospace, civil, and other alliedengineering fields. It offers a unified treatment forsolid and fluid mechanics using a continuummechanics approach. This approach helps students understand both disciplines and preparesthem to face problems in interdisciplinary areassuch as biomechanical engineering . . . Overall,this lucidly presented work provides a valuableintroduction to engineering mechanics using acontinuum approach.”

—R. Kolar, Naval Postgraduate School, in Choice:Current Reviews for Academic Libraries

The essence of continuum mechanics—theinternal response of materials to external load-ing—is often obscured by the complex mathe-matics of its formulation. By building graduallyfrom one-dimensional to two- and three-dimen-sional formulations, this book provides an acces-sible introduction to the fundamentals of solidand fluid mechanics, covering stress and strainand other key topics. This undergraduate textpresents several real-world case studies, such asthe St. Francis Dam, to illustrate the mathemati-cal connections between solid and fluidmechanics. The emphasis is on practical applica-tions of these concepts to mechanical, civil, andelectrical engineering structures and design.

• Summarizes material usually covered overseveral semesters

• Uses case studies to demonstrate the signifi-cance of concepts to historical and contem-porary engineering design

• Features a conversational style that makes iteasily accessible to undergraduate students

• Covers both continuum mechanics andmathematics

• Makes explicit connections among conceptsthat are typically not understood until thegraduate level

Catalog no. 62719, November 2008, 485 pp.ISBN: 978-1-4200-6271-7, $99.95 / £63.99





BiomechanicsPrinciples andApplications, Second EditionEdited by

Donald R. PetersonUniversity of Connecticut,Farmington, USA

Joseph D. BronzinoTrinity College, Hartford,Connecticut, USA

Drawn from the third edition of the widelyacclaimed The Biomedical Engineering Handbook,Biomechanics is a comprehensive presentation ofthe current principles and applications of biome-chanics integrating both systems and subsystemsmodels. Presenting substantial updates and revi-sions and a new chapter on current methods andstrategies for modeling cellular mechanics, thebook covers musculoskeletal mechanics includinghard- and soft tissue and joint mechanics, biofluidmechanics and circulatory dynamics, the function-ing of the ear, and the performance characteristicsof the human body during exercise and exertion.

Catalog no. 8534, September 2007, 352 pp.,ISBN: 978-0-8493-8534-6, $104.95 / £66.99Also available as eBook

Biomechanics in ErgonomicsSecond EditionEdited by

Shrawan KumarUniversity of North Texas, Fort Worth, USA

Safety or comfort? Can you truly have one with-out the other? Is it feasible to have both?Although by no means the only factor, a deepunderstanding of biomechanics plays a leadingrole in the design of work and workplaces thatare both pain and injury free. Standing firmly onthe foundation built by the previous edition, thesecond edition of Biomechanics in Ergonomicsestablishes an understanding of gross biome-chanical loads on the human system at the tissuelevel, then brings that understanding through tothe whole body level

Produced under the aegis of editor ShrawanKumar with contributors who are leading schol-ars in the field, the book contains unique chap-ters such as Exposure Assessment Tools andTechniques and Cumulative Load and Models. Alsoincluded is a chapter on hand tools, which has areal application to the field of ergonomics.

The book dives deep into the biomechanics ofthe connective tissues then thoroughly coversupper and lower extremities, shoulder and neck,low back, and whole body mechanics. Withchapters selected and designed to provideextensive coverage of ergonomically relevantbiomechanics, the book supplies an integratedunderstanding of the inseparable relationshipbetween ergonomics and biomechanics that canbe translated into better safety design and bet-ter workplaces.

• Features a whole body approach, includingtissues, organs, and various regions of thebody

• Offers exposure assessment tools and techniques

• Supplies scientific bases and mechanisms ofhow risk factors precipitate injuries

• Considers posture, postural loads, posturecorrection, and their impact on body regions,working environments, and activities

Catalog no. 7908, December 2007, 744 pp.ISBN: 978-0-8493-7908-6, $115.95 / £73.99Also available as eBook

Foot and AnkleMotion AnalysisClinical Treatmentand TechnologyEdited by

Gerald F. Harris,Peter A. Smith, andRichard M. MarksOriginating as a one-day workshop sponsoredby the Shriner’s Hospitals and the NationalInstitutes of Health, this text is a one-stop refer-ence for assessment technologies and their clin-ical applications. Presenting basic and advancedclinical applications in pediatric and adult cases,the book also introduces the technologicaladvances themselves from a quantitative per-spective. It describes novel approaches andemerging horizons related to mechanical para-digms, imaging, kinetics, robotics and simula-tion, tri-planar force sensing, and more. Thebook also includes a chapter of references andsources of support for future research and devel-opment prospects.






Solid & Fluid Mechanics Biotransport

Biomechanicsand ExercisePhysiologyQuantitativeModelingArthur T. JohnsonUniversity of Maryland, College Park, USA

Using numerous worked examples to demonstratewhat and when to calculate, this text covers morethan just the fundamentals of exercise physiology;it demonstrates the vast amount of physiologicalmaterial that can be quantitatively predicted anddescribes how to translate this information intoapplications. The book examines the energetics ofexercise, biomechanics, circulation, respiration,and thermoregulation, and includes numericalexamples and homework problems. With anemphasis on quantitative description, it includestables and illustrations which make this book help-ful for estimating magnitudes, determining trends,and illustrating concepts.

Catalog no. DK5813, March 2007, 688 pp.ISBN: 978-1-57444-906-8, $135.95 / £87.00

Biomechatronicsin Medicine andHealthcareEdited by

Raymond Tong KaiyuHong Kong PolytechnicUniversity, Hung Hom, Kowloon

This book presents experts’ insights into theemerging technologies and developments thatare being or will be utilized in the medical pro-fession to meet a variety of clinical challenges. Itdemonstrates the application of biomechatron-ics to provide better care and service. It alsoincorporates new and exciting multidisciplinaryareas of research across the medical and engi-neering fields, such as robotic therapeutic train-ing system for stroke rehabilitation, exoskeletonsfor daily activities on persons with disability,functional electrical stimulation, and wirelessactive capsule endoscopy. Each chapter providessubstantial background material relevant to theparticular subject.

Catalog no. N10425, August 2011, 250 pp.ISBN: 978-981-4241-61-8, $149.95 / £95.00Also available as eBook

Advances inNumerical Heat TransferVolume IIIEdited by

W.J. Minkowycz,E.M. Sparrow,and J.P. Abraham

With contributions from a team of renownedinternational researchers who cover both funda-mentals and applications, this volume provides adefinitive treatment of the numerical simulationof bioheat transfer and fluid flow. It covers novelmodeling techniques and numerical simulationfor solving problems in biomedical engineering.The book presents various forms of the bioheatequation appropriate for several thermal thera-pies, such as laser irradiation. It also discussestumor detection and treatment, shows hownanoparticles can be used to improve the effica-cy of tumor treatment, and includes a detailedcase study describing the thermal ablation of anenlarged prostate.

Selected Contents

Synthesis of Mathematical Models RepresentingBioheat Transport. Numerical Models of BloodFlow Effects in Biological Tissues. NumericalMethods for Solving Bioheat Transfer Equationsin Complex Situations. Discrete Vasculature(DIVA) Model Simulating the Thermal Impact ofIndividual Blood Vessels for In Vivo HeatTransfer. Numerical Bioheat Transfer in TumorDetection and Treatment. Thermal Interactionsbetween Blood and Tissue: Development of aTheoretical Approach in Predicting BodyTemperature during Blood Cooling andRewarming. Experimental and NumericalInvestigation on Simulating Nanocryosurgery ofTarget Tissues Embedded with Large BloodVessels. Whole-Body Human Thermal Models.Computational Infrastructure for the Real-TimePatient-Specific Treatment of Cancer. AMathematical Model to Predict TissueTemperatures and Necrosis during MicrowaveThermal Ablation of the Prostate.

Catalog no. 95218, March 2009, 400 pp.ISBN: 978-1-4200-9521-0, $174.95 / £112.00Also available as an eBook




Biotransport


Basic Transport Phenomena in Biomedical EngineeringThird EditionRonald L. FournierUniversity of Toledo, USA

Encompassing a variety of engineering disci-plines and life sciences, the very scope andbreadth of biomedical engineering presentschallenges to creating a concise, entry-level textthat introduces basic concepts without gettingoverly specialized in subject matter or rarified inlanguage. Basic Transport Phenomena inBiomedical Engineering, Third Edition meetsand overcomes these challenges to provide thebeginning student with the foundational toolsand the confidence they need to apply thesetechniques to problems of ever greater com-plexity.

Bringing together fundamental engineering andlife science principles, this highly accessible textprovides a focused coverage of key momentumand mass transport concepts in biomedical engi-neering. It offers a basic review of units anddimensions, material balances, and problem-solving tips, and then emphasizes those chemi-cal and physical transport processes that haveapplications in the development of artificial andbioartificial organs, controlled drug delivery sys-tems, and tissue engineering. The book alsoincludes a discussion of thermodynamic con-cepts and covers topics such as body fluids,osmosis and membrane filtration, physical andflow properties of blood, solute and oxygentransport, and pharmacokinetic analysis. It con-cludes with the application of these principles toextracorporeal devices as well as tissue engineer-ing and bioartificial organs.

Designed for the beginning student, this bookprovides a quantitative understanding of theunderlying physical, chemical, and biologicalphenomena involved. Encouraging students towork examples with the mathematical softwarepackage of their choice, this text provides themthe opportunity to explore various aspects of thesolution on their own, or apply these techniquesas starting points for the solution to their ownproblems

• Provides an introductory level text for students in bioengineering, chemical engineering, mechanical engineering, andthe life sciences

• Presents a basic understanding and the theories of transport in biological systems

• Shows real-world applications in the development and design of artificial organs,drug delivery systems, and tissue engineering

• Includes numerous examples with a discussion of the numerical methods used to solve the problems

• Contains an extensive bibliography of theresearch literature that supports the materialin the text

• Supplies homework problems that give students the opportunity to explore ingreater detail the material covered in each chapter


Selected Contents

Introduction. A Review of ThermodynamicConcepts. Physical Properties of the Body Fluidsand the Cell Membrane. The Physical and FlowProperties of Blood. Solute Transport inBiological Systems. Pharmacokinetic Analysis.Extracorporeal Devices. Tissue Engineering.Bioartificial Organs. Index.

Catalog no. K11304, August 2011, 483 pp.ISBN: 978-1-4398-2670-6, $89.95 / £44.99Also available as an eBook


27

General Books in Bioengineering


New!

Introduction to Biomedical Engineering TechnologySecond EditionLaurence StreetRosedale, British Colombia, Canada

Medical devices are often very complex, but whilethere are differences in design from one manufac-turer to another, the principles of operation and,more importantly, the physiological and anatomi-cal characteristics on which they operate are uni-versal. Introduction to Biomedical EngineeringTechnology, Second Edition explains the usesand applications of medical technology and theprinciples of medical equipment management tofamiliarize readers with their prospective workenvironment.

Written by an experienced biomedical engineer-ing technologist, the book describes the techno-logical devices, various hardware, tools, and testequipment used in today’s health-care arena.Photographs of representative equipment; thetechnical, physiological, and anatomical basis fortheir function; and where they are commonlyfound in hospitals are detailed for a wide range ofbiomedical devices, from defibrillators to electro-surgery units.

Throughout, the text incorporates real-life exam-ples of the work that biomedical engineering tech-nologists do. Appendices supply useful informa-tion such as normal medical values, a list of regu-latory bodies, Internet resources, and informationon training programs. Thoroughly revised andupdated, this second edition includes more exam-ples and illustrations as well as end-of-chapterquestions to test readers’ understanding.

This accessible text supplies an essential overviewof clinical equipment and the devices that are useddirectly with patients in the course of their care fordiagnostic or treatment purposes. The author’spractical approach and organization, outliningeveryday functions and applications of the variousmedical devices, prepares readers for situationsthey will encounter on the job.

• Covers a wider range of devices and includesan expanded section on equipment management

• Describes the day-to-day work of biomedicalengineering technologists using extensiveexamples

• Offers chapter summaries and questions toaid in reader comprehension

• Contains more than 360 illustrations

• Includes a 16-page grayscale insert with photographs of real-life equipment problems

• Provides appendices listing normal medicalvalues, biomedical associations, test equipment manufacturers, helpful Internetresources, and more


Selected Contents

Introduction. Diagnostic Devices: Part One.Diagnostic Devices: Part Two. DiagnosticDevices: Part Three. Diagnostic Imaging.Treatment Devices: Part One. TreatmentDevices: Part Two. Treatment Devices: PartThree. Biomedical Engineering Technologist(BMET) Work. Testers and Tools. Batteries,Radiation, and Computers. TechnologyManagement. Appendix A: Normal Values.Appendix B: Regulations and Standards.Appendix C: Biomedical EngineeringTechnology Programs in the United States andCanada. Appendix D: Biomedical Associations.Appendix E: Devices and Manufacturers.Appendix F: Test Equipment Manufacturers.Appendix G: Bibliography and InternetResources. Index.

Catalog no. K12781, October 2011, 391 pp.ISBN: 978-1-4398-6058-8, $89.95 / £56.99Also available as eBook




BiomimeticsNature-BasedInnovationEdited by

Yoseph Bar-CohenJPL/Caltech, Pasadena,California, USA

Humans have always looked to nature’s inven-tions as a source of inspiration. The observation offlying birds and insects leads to innovations inaeronautics. Collision avoidance sensors mimicthe whiskers of rodents. Optimization algorithmsare based on survival of the fittest, the seed-pick-ing process of pigeons, or the behavior of antcolonies. In recent years these efforts havebecome more intensive, with researchers seekingrules, concepts, and principles of biology toinspire new possibilities in materials, mechanisms,algorithms, and fabrication processes. A review ofthe current state of the art, Biomimetics: NatureBased Innovation documents key biological solu-tions that provide a model for innovations in engi-neering and science.

With contributions from leading experts, thebook explores a wide range of applications of bio-mimetics across a variety of fields. Offering myri-ad examples of technologies inspired by biology,the book discusses artificial senses and organs;mimicry at the cell–materials interface; and mod-eling of plant cell wall architecture and tissuemechanics. It also covers biomimetic composites,artificial muscles, refreshable braille displays, andmore. A series of chapters examines applicationsof biomimetics in manufacturing, products, med-icine, and robotics—including medical devices,implants, and the development of human-likerobots. Contributors also explore biologicallyinspired design as a tool for interdisciplinary edu-cation and describe the biomimetic process inartistic creation. The final chapter outlines thechallenges to biomimetic-related innovation andoffers a vision for the future.

This book features an abundance of illustrations,including a 32-page full-color insert, and providesextensive references for engineers and scientistsinterested in delving deeper into the study of bio-mimetics.


HealthcareSensorNetworksChallenges Toward PracticalImplementationEdited by

Daniel Tze Huei Lai and Rezaul BeggVictoria University, Melbourne, Australia

Marimuthu PalaniswamiUniversity of Melbourne, Parkville, Victoria, Australia

From network deployment to secure monitor-ing, this book addresses the latest developmentsin healthcare sensor networks—medical moni-toring devices implanted on the body or in thesurrounding infrastructure. The text discussesfundamental concepts and provides examples ofclinical applications, including sensors to moni-tor physical activity in children and wearablegait assistants for people with Parkinson’s. Eachchapter details a separate challenge in designand implementation. Addressing topics rangingfrom sensor hardware and the demand for high-er data bandwidth to portability and cost, thebook highlights the key areas that require fur-ther research for HSNs to become a technologi-cal and commercially viable reality.

• Presents new solutions to human motionmonitoring with sensors

• Addresses challenges in implementing HSNs• Explores low-power data communications

using wireless transmissions through thehuman body

• Highlights novel security measures for protecting confidential patient data

• Discusses prospect of continuous sensor network operation based on energy harvesting technology

• Offers practical case studies of healthcaresensor networks in use

• Includes more than 140 illustrations

Selected Contents

Sensor Networks in Healthcare: A NewParadigm for Improving Future Global Health.Healthcare and Accelerometry: Applications forActivity Monitoring, Recognition, andFunctional Assessment. IntrabodyCommunication Using Contact Electrodes inLow-Frequency Bands. ...






New!

BiologicallyInspiredRoboticsEdited by

Yunhui LiuThe Chinese University of Hong Kong

Dong SunCity University of Hong Kong, Kowloon

This reference contains cutting-edge material—considerably expanded and with additional analy-sis—from the 2009 IEEE International Conferenceon Robotics and Biomimetics. The 16 chapterscover biologically inspired robot design and con-trol; micro/nano robots for bio-systems and bio-medicine; biological measurement and actuation;and applications of robotics technology to biolog-ical problems. A state-of-the-art resource for grad-uate students and researchers in control engineer-ing, robotics, and biomedical engineering, thistext helps readers understand the technology andprinciples in this emerging field.

• Highlights research trends and future development of biorobotics and biologicallyinspired robot design

• Brings together contributions from well-known experts

• Examines the use of micro and nano robotsfor biomedical applications and cybernetics

• Includes a wealth of illustrations and equations

Selected Contents

Introduction to Biologically Inspired Robotics.CPG-Based Control of Serpentine Locomotion ofa Snake-Like Robot. Analysis and Design of aBionic Fitness Cycle. Human-InspiredHyperdynamic Manipulation. A School of RoboticFish for Pollution Detection in Port. Developmentof a Low-Noise Bio-Inspired Humanoid RobotNeck. Automatic Single-Cell Transfer Module.Biomechanical Characterization of Human RedBlood Cells with Optical Tweezers. NanoroboticManipulation for a Single Biological Cell.Measurement of Brain Activity Using Optical andElectrical Methods. Bowel Polyp Detection inCapsule Endoscopy Images with Color and ShapeFeatures. Classification of Hand Motion UsingSurface EMG Signals. Multifunctional ActuatorsUtilizing Magnetorheological Fluids for AssistiveKnee Braces. Mathematical Modeling of BrainCircuitry during Cerebellar Movement Control. ...

Catalog no. K12555, December 2011, 340 pp.ISBN: 978-1-4398-5488-4, $99.95 / £63.99Also available as eBook

BiomedicalEngineeringPrinciplesSecond EditionArthur B. Ritter,Vikki Hazelwood, and Antonio ValdevitStevens Institute of Technology,New Jersey, USA

Alfred N. AscioneAlcatel-Lucent Technologies, New Jersey, USA

“[Provides] not only an in-breadth overview oncurrent BME fields, but also an in-depth analysisof specific selected topics that are supported byappropriate mathematical models, equations,quantitative data charts and tables.”

—Biomedical Engineering Online

“... an excellent textbook for a class. Each chaptercontains numerous examples and contains manyfigures to enhance learning. ... Problems areincluded at the end of chapters, where they willbest test the student's knowledge. ... For practicingengineers without biomedical engineering back-ground, the book provides an excellent resource toexplain the many intricacies of biomedical engi-neering and provides sufficient background mate-rial to make the subject understandable.”

—Richard C. Fries, PE, CRE, Baxter Healthcare, Inc., inIEEE Engineering in Medicine and Biology Magazine

“This book is written at a reasonably high scien-tific level; it employs mathematics, basic physics,chemistry, and thermodynamics of the main med-ical processes. It is well illustrated with figures,schemes, various plots, and mathematical equa-tions. This book will definitely be useful for bio-chemists, biophysicists, and specialists in cell biol-ogy and medicine.”

—G. Ya. Wiederschain, Doctor of Biological Science,Moscow State University, Russia

Integrating engineering, medicine, biology, andphysics, this book clearly defines basic principlesin image processing and biomechanics, model-ing physiological processes, and bioelectric sig-nal analysis to build a solid understanding ofdevices and designs for improved functioning ofthe human body.

Solutions manual and figure slides available upon qualifying course adoption

Selected Contents

Introduction: Modeling of PhysiologicalProcesses. Cell Physiology and Transport. ...

Catalog no. K10621, May 2011, 540 pp.ISBN: 978-1-4398-1232-7, $99.95 / £63.99Also available as eBook





New!

Biological andMedical SensorTechnologiesEdited by

Krzysztof IniewskiCMOS Emerging Technologies,Inc., Vancouver, BritishColumbia, Canada

Edited by a pioneer in the area of advancedsemiconductor materials, Biological andMedical Sensor Technologies contains contribu-tions from experts, exploring the developmentand use of sensors in biological and medicalapplications. It covers topics including advancedsensing and communications in biology, as wellas physics and modeling of DNA-derivativearchitecture, and the use of enzyme and quartzcrystal microbalance-based biosensors. Thebook also addresses biosensors in human behav-ior measurement, sweat rate wearable sensors,and the future of medical imaging, includingdevelopments in spatial and spectral resolutionof semiconductor detectors. Contributors coverapplication of high-resolution CdTe detectors ingamma ray imaging, and recent advances inpositron emission tomography technology.

Selected Contents

Part I: Sensors for Biological ApplicationsAdvanced Sensing and Communication inBiological World. Physics and Modeling ofDNA-Derivative Architectures for Long-Wavelength Bio-Sensing. Label-Free Biosensorsfor Biomedical Applications: The Potential ofIntegrated Optical Biosensors and SiliconPhotonics. Quartz Crystal Microbalance–BasedBiosensors. Toward Printable Lab-on-a-ChipTechnologies for Cell Analytics. Construction ofEnzyme Biosensors Based on a CommercialGlucose Sensor Platform. Future Directions forBreath Sensors. Solid-State Gas Sensors forClinical Diagnosis.Part II: Sensors for Medical ApplicationsBiosensors and Human Behavior Measurement:A State-of-the-Art Review. Sweat Rate WearableSensors. Future of Medical Imaging. Spatial andSpectral Resolution of Semiconductor Detectorsin Medical Imaging. Advances in CMOS SSPMDetectors. High-Resolution CdTe Detectors andTheir Application to Gamma-Ray Imaging.Recent Advances in Positron EmissionTomography Technology.

Catalog no. K13895, February 2012, 412 pp.ISBN: 978-1-4398-8267-2, $149.95 / £95.00Also available as an eBook

New!

Analysis andApplication ofAnalogElectronicCircuits toBiomedicalInstrumentationSecond EditionRobert B. NorthropUniversity of Connecticut, Storrs, USA

This book helps biomedical engineers under-stand and design signal conditioning systemsusing analog integrated circuits. It explains theelectronic components and subsystems—the"building blocks"—that are used in ECG, EEG,EMG, ERG, tomographic images, biochemicalspectrograms, and other crucial medical applica-tions. This second edition has been substantiallyupdated and revised. It now features a glossary,new end-of-chapter problems, and three newchapters that address wireless patient monitor-ing using UHF telemetry; power amplifiers andtheir applications to biomedical instruments;and RFID, GPS, and ultrasonic tags used in eco-logical research. • Introduces the basic mathematical tools used

to describe noise and its propagationthrough linear systems

• Describes, at a basic level, how to improvesignal-to-noise ratios with signal averagingand linear filtering

• Shows how op amps can be used to buildinstrumentation amplifiers, isolation amplifiers,active filters, and many other systems andsubsystems used in biomedicalinstrumentation

• Provides end-of-chapter problems and examples that emphasize biomedical electronic applicationsSolutions manual available upon qualifying course adoption

Selected Contents

Sources and Properties of Biomedical Signals.Properties and Models of Semiconductor DevicesUsed in Analog Electronic Systems. TheDifferential Amplifier. General Properties ofElectronic, Single-Loop Feedback Systems.Feedback, Frequency Response, and AmplifierStability. Operational Amplifiers andComparators. ...Catalog no. K12982, March 2012, 578 pp.,ISBN: 978-1-4398-6669-6, $119.95 / £76.99Also available as an eBook



31



New!

ElectromagneticFields inBiologicalSystemsEdited by

James C. LinUniversity of Illinois at Chicago, USA

As wireless technology becomes more sophisticat-ed and accessible to more users, the interactionsof electromagnetic fields with biological systemshave captured the interest not only of the scientif-ic community but also the general public.Unintended or deleterious biological effects ofelectromagnetic fields and radiation may indicategrounds for health and safety precautions in theiruse. Spanning static fields to terahertz waves,Electromagnetic Fields in Biological Systemsexplores the range of consequences these fieldshave on the human body. With contributions by an array of experts, topicsdiscussed include:

• Essential interactions and field couplingphenomena, highlighting their importance inresearch on biological effects and in scientific,industrial, and medical applications

• Electric field interactions in cells, focusing onultrashort, pulsed high-intensity fields

• The effect of exposure to naturally occurringand human-made static, low-frequency, andpulsed magnetic fields in biological systems

• Dosimetry or coupling of ELF fields into biolog-ical systems and the historical developmentsand recent trends in numerical dosimetry

• Mobile communication devices and thedosimetry or coupling of RF radiation into thehuman body

• Exposure and dosimetry associated with MRIand spectroscopy

• Available data on the interaction of terahertzradiation with biological tissues, cells,organelles, and molecules

There is great potential for communication,industrial, scientific, and medical use of electro-magnetic fields and radiation. To help advanceknowledge of the biological effects of such fieldsand to exploit their potential medical applica-tions, this book highlights critical issues relatingto their effects on living systems.

Catalog no. K12740, October 2011, 458 pp.ISBN: 978-1-4398-5999-5, $149.95 / £95.00Also available as an eBook

BiomedicalSensors andInstrumentsSecond EditionTatsuo Togawa,Toshiyo Tamura,and P. Åke Öberg

The living body is a difficult object to measure:accurate measurements of physiological signalsrequire sensors and instruments capable of highspecificity and selectivity that do not interferewith the systems under study. As a result,detailed knowledge of sensor and instrumentproperties is required to be able to select the“best” sensor from one of the many designed tomeet these challenges.

From the underlying principles to practical appli-cations, this updated edition of BiomedicalSensors and Instruments provides an easy-to-understand introduction to the various kinds ofbiomedical sensors. The book presents state-of-the-art discussions of sensors for the measure-ments of pressure, flow, motion, temperature,heat flow, evaporation, biopotential, biomag-netism, and chemical quantities.

Features

• Organizes topics so that it is easy to find thebest possible choice of sensors for eachmeasurement situation

• Includes more than 300 updated figures andtables to facilitate an intuitive understanding

• Supplies numerous examples of sensor appli-cations to demonstrate practical methods ofresearch

Selected Contents

Fundamental Concepts

Pressure Measurements

Flow Measurement

Motion and Force Measurement

Temperature, Heat Flow, and EvaporationMeasurements

Bioelectric and Biomagnetic Measurements

Chemical Measurement

Catalog no. 9078X, March 2011, 423 pp.ISBN: 978-1-4200-9078-9, $139.95 / £89.00Also available as an eBook





PracticalBiomedicalSignal AnalysisUsing MATLAB®K.J. Blinowska and J. ŻygierewiczUniversity of Warsaw, Poland

Practical Biomedical Signal Analysis Using MAT-LAB® presents a coherent treatment of varioussignal processing methods and applications. Thebook not only covers the current techniques ofbiomedical signal processing, but it also offersguidance on which methods are appropriate fora given task and different types of data.The first several chapters of the text describe sig-nal analysis techniques—including the newestand most advanced methods—in an easy andaccessible way. MATLAB routines are listed whenavailable and freely available software is dis-cussed where appropriate. The final chapterexplores the application of the methods to abroad range of biomedical signals, highlightingproblems encountered in practice.A unified overview of the field, this bookexplains how to properly use signal processingtechniques for biomedical applications andavoid misinterpretations and pitfalls. It helpsreaders to choose the appropriate method aswell as design their own methods.

• Provides hands-on guidance for those work-ing in the area of biomedical signal analysis

• Covers tools for stationary and non-stationarysignals, non-linear methods of signal analysis,and models and measures for multivariatesignals

• Compares the advantages and disadvantagesof different methods in the context of appli-cations

• Refers to MATLAB routines and freely avail-able software found on the Internet

• Applies the methods to a variety of electric,magnetic, and acoustic signals

Selected Contents

Introductory Concepts. Single Channel(Univariate) Signal. Multiple Channels(Multivariate) Signals. Application to BiomedicalSignals. References. Index.


Introduction toComplexity andComplexSystemsRobert B. NorthropUniversity of Connecticut, Storrs, USA

The boundaries betweensimple and complicated,and complicated and com-plex system designations are fuzzy and debatable,even using quantitative measures of complexity.However, if you are a biomedical engineer, a biol-ogist, physiologist, economist, politician, stockmarket speculator, or politician, you have encoun-tered complex systems. Furthermore, your successdepends on your ability to successfully interactwith and manage a variety of complex systems. Inorder not to be blindsided by unexpected results,we need a systematic, comprehensive way of ana-lyzing, modeling, and simulating complex systemsto predict non-anticipated outcomes. In its engaging first chapters, the book introducescomplex systems, Campbell's Law, and the Law ofUnintended Consequences, and mathematics nec-essary for conversations in complex systems.Subsequent chapters illustrate concepts via com-monly studied biological mechanisms. The finalchapters focus on higher-level complexity problems,and introduce complexity in economic systems. Designed as a reference for biologists and biologi-cal engineers, Introduction to Complexity andComplex Systems lends itself to use in a class-room course to introduce advanced studentsstudying biomedical engineering, biophysics, orphysiology to complex systems. Engaging andillustrative, this book aids scientists and decisionmakers in managing biological complexity andcomplex systems.

• Describes the characteristics of certain complex living systems

• Provides dynamic models for various complexsystems

• Offers present-day examples for dealing withcomplex systems

• Includes homework problems for better comprehension

Selected Contents

Introduction to Complexity and ComplexSystems. Introduction to Large Linear Systems.Introduction to Nonlinear Biochemical Systemsand Biochemical Oscillators. ...

Catalog no. K11775, December 2010, 551 pp.ISBN: 978-1-4398-3901-0, $83.95 / £53.99Also available as eBook



33



Dynamics of BiologicalSystemsMichael SmallHong Kong PolytechnicUniversity

From the spontaneous rapidfiring of cortical neurons tothe spatial diffusion of dis-ease epidemics, biologicalsystems exhibit rich dynamic behaviour over a vastrange of time and space scales. Unifying many ofthese diverse phenomena, Dynamics ofBiological Systems provides the computationaland mathematical platform from which to under-stand the underlying processes of the phenome-na.Through an extensive tour of various biologicalsystems, the text introduces computational meth-ods for simulating spatial diffusion processes inexcitable media, such as the human heart, as wellas mathematical tools for dealing with systems ofnonlinear ordinary and partial differential equa-tions, such as neuronal activation and disease dif-fusion. The mathematical models and computersimulations offer insight into the dynamics of tem-poral and spatial biological systems, including car-diac pacemakers, artificial electrical defibrillation,pandemics, pattern formation, flocking behaviour,the interaction of autonomous agents, and hierar-chical and structured network topologies. Toolsfrom complex systems and complex networks arealso presented for dealing with real phenomeno-logical systems.

Features

• Uses complex systems, complex networks,and dynamics to derive models and computersimulations of various biological systems

• Presents a wide range of models, from ECGsignal processing to pandemic modelling topopulation dynamics

• Requires no advanced knowledge of mathematics

• Includes exercises as well as computationaland research projects at the end of eachchapter

This classroom-tested text shows readers how toapply a variety of mathematical and computation-al techniques to model and analyze the temporaland spatial phenomena of biological systems.MATLAB® implementations of algorithms and casestudies are available on the author’s website.Solutions manual available upon qualifying course adoption

Catalog no. K12463, August 2011, 284 pp.ISBN: 978-1-4398-5336-8, $79.95 / £49.99Also available as eBook

Biology forEngineersArthur T. JohnsonUniversity of Maryland, College Park, USA

Biology is a critical applica-tion area for engineeringanalysis and design, and students in engineeringprograms must be well-versed in the fundamen-tals of biology as they relate to their field. Biologyfor Engineers is an introductory text that mini-mizes unnecessary memorization of connectionsand classifications and instead emphasizes con-cepts, technology, and the utilization of livingthings.Classroom-tested at the University of Maryland,this comprehensive text introduces concepts andterminology needed to understand moreadvanced biology literature. Filled with practicaldetailed examples, the book presents:

• Scientific principles relevant to biology thatall engineers must know

• A discussion of biological responses from theperspective of a broad range of fields such aspsychology, human factors, genetics, plantand animal physiology, imaging, control systems, actuary, and medicine

• A thorough examination of the scaling ofbiological responses and attributes

• A classification of different types of applicationsrelated to biological systems

• Tables of useful information that are nearlyimpossible to find elsewhere

Emphasizing the ever-present interactionsbetween a biological unit and its physical, chemi-cal, and biological environments, the book pro-vides ample instruction on the basics of physics,chemistry, mathematics, and engineering. Itbrings together all of the concepts one needs tounderstand the role of biology in modern tech-nology.


Selected Contents

Introduction. Principles from the Sciences.Responses of Living Systems. Scaling Factors.Utilizing Living Systems. Appendices.References. Index.

Catalog no. 77635, September 2010, 775 pp.ISBN: 978-1-4200-7763-6, $104.95 / £66.99Also available as eBook





Signals andSystemsAnalysis inBiomedicalEngineeringSecond EditionRobert B. NorthropUniversity of Connecticut,Storrs, USA

The interdisciplinary field of biomedical engi-neering requires its practitioners to know andmaster not only engineering skills, but also adiversity of material in the biological sciences.This text helps biomedical engineering studentsand professionals strengthen their skills in thenetwork of applied mathematics that tiestogether these diverse disciplines. Based on theauthor's 30 years of experience in teaching aswell as his personal research on neurosensorysystems, this book, now in its second edition,provides a ready source of information on thespecialized mathematical techniques most usefulin describing and analyzing biomedical signals.

• Focuses on the mathematical tools required toanalyze and describe the signals and systemsfound in biomedical engineering

• Includes a comprehensive chapter on jointtime-frequency analysis of nonstationary biomedical signals, and the use of wavelets in JTFA

• Explores the mathematics of tomographicimaging

• Describes the analytical signal and the Hilberttransform

• Discusses the analysis of nonlinear systems,nonlinear oscillators, and biological clocks

• Introduces the analysis of and modeling strategies for complex systems


Selected Contents

Introduction to Biomedical Signals and Systems.Review of Linear Systems Theory. The LaplaceTransform and Its Applications. Fourier SeriesAnalysis of Periodic Signals. The ContinuousFourier Transform. The Discrete FourierTransform. Introduction to Joint TimeFrequencyAnalysis of Biomedical Signals. Introduction tothe Analysis of Stationary Noise, and SignalsContaminated with Noise. Basic MathematicalTools Used in the Characterization ofPhysiological Systems. Introduction to theMathematics of Tomographic Imaging. ...

Catalog no. K10633, March 2010, 654 pp.ISBN: 978-1-4398-1251-8, $104.95 / £66.99

Introduction toMolecularBiology,Genomics andProteomics forBiomedicalEngineersRobert B. Northrop and Anne N. ConnorUniversity of Connecticut, Storrs, USA

“The book provides a solid introduction and afoundation that the interested student might useas a basis for further study at a more advancedlevel.”

—Books-On-Line

A unique introductory text, this book is writtenfor engineers and scientists with little back-ground in molecular biology, genomics, andproteomics, who are working with, or planningto work with, living systems. The authors assumefamiliarity with basic calculus, physics, and linearalgebra. They describe the very complex bio-chemical relations that permit life to exist, high-lighting the specialized organic molecules in liv-ing organisms, and how they interact and react.This is a professional primer, not intended as areplacement for formal, in-depth course work,but intended to broaden the background andpique the interest of those new to this area.

• Defines complex terminology in a large, comprehensive glossary

• Addresses ethical issues in stem cell research,cloning, and the creation of genetically-modified plants and animals

• Contains a sizeable bibliography for furtherindependent study of discussed topics

• Describes the role of stem cells in regenerativemedicine and in cancer treatment

• Comprises robust chapters on nucleic acidsand proteins—the building blocks of molecularbiology

Selected Contents

Introduction. Life and Death. Review of Basic CellAnatomy and Physiology. Introduction to PhysicalBiochemistry and Biochemical Systems Modeling.The Basis of Genetic Inheritance. Nucleic Acidsand Their Functions. A Review of Proteins. TheGenetic Basis for Certain Inheritable Diseases:Genomic Medicine. Some Instrumental MethodsUsed in Genomics, Proteomics, and ForensicScience. Applications of Genomics. ...

Catalog no. 61194, October 2008, 480 pp.ISBN: 978-1-4200-6119-2, $107.95 / £69.99



35



AppliedBiomedicalEngineeringMechanicsDhanjoo N. GhistaWayland, Massachusetts, USA

Combining topics fromnumerous applications inbiomechanics, AppliedBiomedical EngineeringMechanics demonstrates how to analyze physio-logical processes from an engineering perspectiveand apply the results to tertiary medical care. Thebook extends its discussion to the investigation ofdiagnostic and surgical procedures. It also pres-ents guidelines for prostheses design and explainshow to optimize performance in sports such assoccer, baseball, and gymnastics.Using a problem-based format, the book explainshow to formulate diagnostic and interventionalprocedures based on the analysis of physiologicaland organ system-based processes and developorthopedic surgical approaches using pre-surgicalanalysis. It goes on to cover how to assess and pro-mote fitness and analyze sports games to maxi-mize competency.

• Incorporates material from solid mechanics,fluid mechanics, dynamics and vibrations, control systems, and mathematical modeling

• Provides biomechanical guidelines for internalfixation of bone and spinal fractures as well asthe treatment of herniated discs

• Presents the mechanics of heart function, heartstructures, the noninvasive determination ofaortic pressure, and the characterization of left-ventricular afterload

• Discusses the detection of infarcted myocardialsegments

• Assesses the constitutive properties and degen-eration of heart valves

• Covers the modeling of lung ventilation, itsapplication to lung disease diagnosis, lung gas-transfer mechanism, and indices to assessits performance

• Examines how human anatomical structuresand physiological processes are designed foroptimal functionalit

The world-class instruction presented withinApplied Biomedical Engineering Mechanicsclearly demonstrates how to quantify physiologi-cal processes in order to formulate solutions to var-ious medical problems.

Catalog no. DK8315, July 2008, 552 pp.ISBN: 978-0-8247-5831-8, $149.95 / £96.00Also available as eBook

Technology and MedicalSciencesEdited by

Renato Natal Jorge, João Manuel R.S.Tavares, Marcos Pinotti,and Alan Peter SladeThe use of more robust, affordable, and efficienttechniques and technologies in the applicationof medicine is presently a subject of huge inter-est and demand. The main purpose of this bookis to solidify knowledge in the fields of technolo-gy and medical sciences and to define their keystakeholders. It offers comprehensive coverageof the current state of the art, including com-puter assisted surgery, implantology, artificialorgans, medical robotics, minimally invasivedevices and techniques, bioengineering, techni-cal aids, telemedicine, computer aided diagno-sis, virtual reality, software development, simula-tion, and more.

Catalog no. K13050, January 2011, 376 pp.ISBN: 978-0-415-66822-4, $139.00 / £89.00Also available as eBook

Bionanotech-nology IIGlobal ProspectsEdited by

David E. ReisnerThe Nano Group, Inc.,Farmington, Connecticut, USA

A blend of information from the BiomedicalEngineering Handbook and new material, thisbook draws on the experience of experts fromaround the world. Reflecting the increasingimportance of nanomedicine and biotechnolo-gy, this material covers topics such as bio-mimicry, stem cells, optical togs, and nanocoat-ings. The book also provides insights into thefood and cosmetics industries, as well as cardiacdiagnosis, batteries, drug delivery, photonics,and DNA building blocks. It also discusses pro-tein devices, quantum dots, bioanalysis, optics,nanomedicine, personalized medicine, and thebusiness of emerging bionanotech companies.

Catalog no. K10254, August 2011, 583 pp.,ISBN: 978-1-4398-0463-6, $99.95 / £63.99Also available as eBook






BasicIntroduction toBioelectromag-neticsSecond EditionCynthia Furse, Douglas A. Christensen,and Carl H. DurneyUniversity of Utah, Salt Lake City, USA

This revised and updated edition facilitates theprocess of interdisciplinary research by introducinglife scientists to the basic concepts of electromag-netic fields. The book outlines elements of EM thatare helpful to life scientists working with physicistsand electrical engineers. Each concept is presentedwith an associated application and discussion.Example applications include MRI, NMR, ultra-sound, hyperthermia, neural stimulation, and car-diac pacing/defibrillation. With the liberal use ofdiagrams and graphs, this text covers the entire fre-quency spectrum through optical frequencies froma qualitative perspective beneficial to life scientists.

Catalog no. 55429, March 2009, 288 pp.ISBN: 978-1-4200-5542-9, $107.95 / £69.99Also available as eBook

Bionanotech-nologyGlobal ProspectsEdited by

David E. ReisnerThe Nano Group, Inc.,Farmington, Connecticut, USA

As the impact of nanotechnology continues togrow, it is important for biomedical engineers tohave a deeply rooted understanding of bionan-otechnologies. Featuring chapters drawn fromthe third edition of the bestselling Handbook ofBiomedical Engineering as well as new contribu-tions not found in the Handbook,Bionanotechnology takes a broad survey of theresearch and activities shaping this burgeoningfield. Covering technical and non-technicalareas, the book discusses the role of nanotech-nology in novel medical devices, bioanalyticaltechnologies, and nano-biomaterials, as well asintellectual property issues that are unique tonanotechnologies.

Catalog no. 7528, July 2008, 368 pp.ISBN: 978-0-8493-7528-6, $104.95 / £66.99Also available as eBook

Coming Soon!

Biosensors andMolecularTechnologiesfor CancerDiagnosticsEdited by

Keith E. Herold and Avraham RasoolyBiosensors are expected to play an expanding rolein the early detection and treatment of cancer.Addressing cancer molecular diagnostics from theperspective of biosensors and biodetection, thisbook examines the technology and applications ofa range of sensor systems, including optical, elec-trochemical, and optomechanical sensors. Eachchapter presents a different biosensor-based tech-nology and then explains their limitations, how thesensors are created, how they function, and howthey can be applied. The text also reviews alliedsubjects, such as ligands, molecular markers, andmicrofluidics, that are essential to understandingand developing new sensing technologies.

Catalog no. K11937, June 2012, c. 840 pp.,ISBN: 978-1-4398-4165-5, $169.95 / £108.00Also available as eBook

ComputationalIntelligence inBiomedicalEngineeringRezaul BeggVictoria University, Melbourne, Australia

Daniel T.H. Lai andMarimuthu PalaniswamiUniversity of Melbourne, Australia

In recent years, there has been an explosion ofinterest in CI techniques as evidenced by numer-ous applications in various fields. Biomedicalresearch and applications have benefited enor-mously as a result of applications of such toolsand techniques. However, most of the scientificliterature on the application of CI for modelingand pattern recognition is scattered in differentjournals and conference proceedings. This bookprovides a comprehensive account of recentresearch efforts in this emerging area. It bringstogether in a single volume research and appli-cations of computational intelligence.

Catalog no. 4080, December 2007, 392 pp.ISBN: 978-0-8493-4080-2, $149.95 / £96.00Also available as eBook





Forthcoming


The MedicalDevice R&DHandbookSecond EditionEdited by

Theodore R. KucklickTRKD Medical Devices, Los Gatos, California, USA

Catalog no. K10598, August 2012, c. 550 pp.ISBN: 978-1-4398-1189-4, $139.95 / £89.00Also available as eBook

AdvancedMaterials forJoint ImplantsGiuseppe PezzottiKyoto Institute of Technology,Japan

Catalog no. N10574, July 2012, c. 400 pp.,ISBN: 978-981-4316-88-0, $179.95 / £114.00Also available as eBook

Heart RateVariability(HRV) SignalAnalysisClinical ApplicationsEdited by

Markad V. KamathMcMaster University, Hamilton, Ontario, Canada

Mari A. WatanabeAdrian UptonMcMaster Medical Centre, Hamilton, Ontario, Canada

Catalog no. K12259, September 2012, c. 544 pp.ISBN: 978-1-4398-4980-4, $149.95 / £95.00

The BiomedicalEngineeringHandbookMolecularEngineering, Fourth EditionJoseph D. BronzinoDonald R. PetersonUniversity of Connecticut,Farmington, USA

Catalog no. K11202, August 2012, c. 1200 pp.Soft Cover, ISBN: 978-1-4398-2527-3$159.95 / £99.00Also available as eBook

BacterialCelluloseA SophisticatedMultifunctionalMaterialMiguel GamaUniversity of Minho,Braga, Portugal

Catalog no. K13216, September 2012, c. 250 pp.ISBN: 978-1-4398-6991-8, $99.95 / £63.99Also available as eBook

A LaboratoryCourse in TissueEngineeringEdited by

Melissa Kurtis MicouUniversity of California, San Diego, USA

Dawn KilkennyUniversity of Toronto, Ontario, Canada

Catalog no. K13694, August 2012, 256 pp.Soft Cover, ISBN: 978-1-4398-7893-4$59.95 / £38.99Also available as eBook








Forthcoming

Fundamentalsof BiomechanicsRonald L. HustonUniversity of Cincinnati, Ohio

Catalog no. K14776, September 2012, c. 500 pp.ISBN: 978-1-4665-1037-1, $99.95 / £63.99

Reliable Designof MedicalDevicesThird EditionRichard C. FriesIsorel, Inc., Fitchburg, Wisconsin, USA


RegenerativeEngineeringEdited by

Cato T. Laurencin and Yusuf KhanUniversity of Connecticut Health Center, Farmington, USA


Physics ofThermalTherapyFundamentals andClinical ApplicationsEdited by

Eduardo MorosMoffitt Cancer Center, Tampa, Florida, USA


Advances inTherapeuticEngineeringEdited by

Wenwei YueChiba University, Japan

SubhagataChattopadhyayNational Institute of Science and Technology, Orissa, India

Teik-Cheng LimSIM University, Singapore

Rajendra AcharyaNgee Ann Polytechnic, Singapore


AmbientAssisted LivingNuno M. GarciaLusophone University ofHumanities and Technologies,Lisbon, Portugal

Joel Jose P.C. RodriguesDirk Christian EliasFraunhofer Portugal, Porto

Miguel Sales DiasMSTF LDA, Quinta Do Conde, Portugal








Resources for Every EngineerContracts for EngineersIntellectual Property, Standards, and EthicsRobert D. HunterRobert D. Hunter Associates, Austin, Texas, USA

As an engineer, you encounter various formsof contracts at nearly every turn in yourcareer. This book helps you communicatecontractual issues to lawyers and betterunderstand the consequent legal advice youreceive. Learn about intellectual property(including patents, copyright, trademarks,and trade secrets), standards, and ethics.Catalog no. K12434, September 2011,368 pp. ISBN: 978-1-4398-5286-6$69.95 / £44.99Also available as eBook

Technical WritingA Practical Guide for Engineers and ScientistsPhillip A. LaplanteThe Pennsylvania State University, Malvern, USA

Written by a renowned engineer and widelypublished technical author, this guide showsyou how to write, edit, and publish materi-als of a technical nature, including books,articles, reports, and electronic media.Offering first-hand examples and personalanecdotes, it complements the traditionalwriter’s reference manuals and other bookson technical writing. Catalog no. K11106, July 2011250 pp., Soft Cover, ISBN: 978-1-4398-2085-8$39.95 / £25.99Also available as eBook



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