Bioactive Small Molecules

468
biomolecules Small Molecules 2011   2012 Catalog

Transcript of Bioactive Small Molecules

  • biomolecules

    Small Molecules 20112012 Catalog

  • Making connections in bio logical.

    Sigma and Sigma-Aldrich are registered trademarks of Sigma-Aldrich Co. and its affi liate Sigma-Aldrich Biotechnology, L.P. Ingenuity is a registered trademark of Ingenuity Systems.

    Save time searching biological information.Find bioactive small molecules in the context of your research.Your Favorite Gene powered by Ingenuity has:

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    Bioconnect.

    Welcome to the Sigma Life Science 20112012 Bioactive Small Molecules catalog.

    This edition contains over 3,000 small molecule tools, including 300 new products for understanding pathway biology.

    This catalog is your window into the largest and most diverse collection of inhibitors, activators, modulators, and approved drugs. From cyclopamine to fl uoxetine and celecoxib, we have bioactive small molecules for the study of all major biological pathways and drug targets. They are backed by world-class technical and customer service, state-of-the-art manufacturing, and an award-winning website.

    Relevant compounds and pharmacological activities

    Hand-picked for characterization and target relevance potent, selective tools for ultimate control of your system

    Ligands, inhibitors, and drugs for almost any pathway or target class

    World-class consistency and quality have confi dence in your results

    The LOPAC 1280 library the power of our small molecule modulators and approved drugs in a convenient, ready-to-screen collection

    Additionally, all of our bioactive small molecules are available for exploration through our powerful Your Favorite Gene search and our new, dedicated bioactive small molecule search so you can fi nd product data faster than ever before.

    Sigmas expanding antibody collection, high-performance proteins, exclusive zinc-fi nger nuclease technology for targeted genome editing, the worlds fi rst knockout rats, the most highly validated RNAi screening portfolio, and our bioactive small molecules are all part of the largest selection of tools and technologies available to further our understanding of biology.

    Sigma Life Science is where bio begins.

    wherebiobegins.com/bioactivity

    biomolecules

    75140_SMC_cvr_r4.indd 475140_SMC_cvr_r4.indd 4 3/7/2011 11:08:53 AM3/7/2011 11:08:53 AM

  • 98% (HPLC)ship: ambient store at: room temp

    E8409-5MG 5 mg

    E8409-25MG 25 mg

    Erastin 8

    2-[1-[4-[2-(4-Chlorophenoxy)acetyl]-1-piperazinyl]ethyl]-3-(2-ethoxyphenyl)-4(3H)-Quinazolinone[571203786] C30H31ClN4O4 FW 547.04

    N

    O

    NN

    O

    CH3

    NO O

    Cl

    CH3

    Erastin is an antitumor agent selective for tumor cells bearing oncogenic RAS.

    98% (HPLC)ship: ambient store at: room temp

    E7781-1MG 1 mg

    E7781-5MG 5 mg

    10058-F4 8

    S

    NH

    O SH3C

    5-[(4-Ethylphenyl)methylene]-2-thioxo-4-thiazolidinone[403811552] C12H11NOS2 FW 249.35

    10058-F4 is a c-Myc inhibitor.

    98% (HPLC)ship: ambient store at: room temp

    F3680-5MG 5 mg

    F3680-25MG 25 mg

    Fasentin 8

    N-[4-Chloro-3-(trifluoromethyl)phenyl]-3-oxobutan-amide[392721378] C11H9ClF3NO2 FW 279.64

    H3C NH

    OO ClCF3

    Fastentin is a novel of glucose uptake, GluT1 inhibitor.

    98% (HPLC)ship: ambient store at: room temp

    F5557-5MG 5 mg

    F5557-25MG 25 mg

    Gambogic acid 8

    O

    O

    OO

    O

    CH3H3C

    H3C

    CH3

    O

    OHH

    H

    H3C

    H3C

    OH

    H3C

    CH3

    Beta-Guttiferrin; B"-Guttiferrin; Cambogic acid; Guttic acid; Guttatic acid; Beta-Guttilactone; 1,51,5-Methano-1H,3H,11H-furo(3,4-G)pyrano(3,2-B)xanthene-1-crotonic acid[2752650] C38H44O8 FW 628.75

    Gambogic acid acts as a caspase activator and apoptosis inducer.

    >97% (HPLC)ship: ambient store at: room temp

    G8171-5MG 5 mg

    G8171-25MG 25 mg

    Gemcitabine hydrochloride 8

    2-Deoxy-2,2-difluorocytidine; dFdC; dFdC; dFdCyd;LY-188011; Gemzar (Lilly)[122111039] C9H11F2N3O4 HCl FW 299.66

    OH F

    FO

    N

    N

    O

    NH2

    HO HCl

    Gemcitabine is a widely used antineoplastic agent and antimetabolite.

    98% (HPLC)ship: ambient store at: room temp

    G6423-10MG 10 mg

    G6423-50MG 50 mg

    HA 14-1

    2-Amino-6-bromo--cyano-3-(ethoxycarbonyl)-4H-1-benzopyran-4-acetic acidethyl ester; Ethyl [2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)]-4H-chromene-3-carboxylateC17H17BrN2O5 FW 409.23

    HA 14-1 is a nonpeptide apoptosis inducer; Bcl-2 antagonist.

    94% (HPLC)ship: ambient store at: room temp

    H8787-5MG 5 mg

    H8787-25MG 25 mg

    Muristerone A

    MurA; 2,3,5,11,14,20R,22R-Heptahydroxycholest-7-en-6-oneC27H44O8

    Muristerone A is a native phytosteroid known to have insecticidal properties.Induces apoptosis in cell transfected with wild-type Bax and ecdysone-inducible gene expression systems in mammalian cells and transgenicanimals.

    90%ship: ambient store at: room temp

    M7888-1MG 1 mg

    Apoptosis and Cell CycleApoptosis Inducers

    Extract Data: #2393, SMC Pg Count File UNP 1215b

    51 Table of Contents

    Introduction 1General Information 2Licensing Requirements 4

    LOPAC Libraries 16Apoptosis and Cell Cycle 19

    Apoptosis Inducers 19Apoptosis Inhibitors 24Caspases 26Cathepsins and Granzymes 28Cell Cycle Regulators 28DNA Metabolism 34Non-apoptotic Cell Death 40PARP 40

    Cytokines Growth Factors and Hormones 43Cytokines and Growth Factors 43Hormones 45

    Cytoskeleton and Extracellular Matrix 63Actin Inhibitors and Probes 63Adhesion Molecules and Related Proteins 64Cell Migration 65Extracellular Matrix 65Microtubule Inhibitors 69Trafficking 71

    Gene Regulation and Expression 73DNA-RNA Transcription Regulators 73Gene Regulation 79Nuclear Receptors 83Nuclear Transport 89RNA-Protein Translation Inhibitors 90

    G Proteins and Cyclic Nucleotides 93G Protein Function 93Cyclic Nucleotide Metabolism 97

    Immune Cell Signaling and Blood 107Immune System Regulation 107Blood 126

    Intracellular Calcium Signaling 127Calcium Antagonists 127Calcium Signaling Research Tools 129Intracellular Calcium Regulators 133

    Ion Channels 135Calcium Channel Modulators 135Monovalent Ion Channels 141

    Kinase/Phosphatase Biology 161Glycogen Phosphorylase 161Non-receptor Tyrosine Kinase Inhibitors 161Receptor Tyrosine Kinase Inhibitors 164Serine/Threonine Kinase Activators 168Serine/Threonine Kinase Inhibitors 171Serine/Threonine Phosphatase Inhibitors 184Tyrosine Kinase-like Inhibitors 184Tyrosine Phosphatase Inhibitors 185

    Lipids in Cell Signaling 189Arachidonic Acid Cascade 189Cholesterol and Cholesterol Metabolism 202Diacylglycerols 206Gangliosides 206Inositol Phosphates 208Palmitoylation and Myristoylation 211Phospholipids 212Phospholipid Metabolism 215Platelet Activating Factors 218Sphingolipids 219Sphingolipid Metabolism 223Other Bioactive Lipids 223

    Multi-Drug Resistance and Drug Metabolism 225Multi-Drug Resistance 225Drug and Xenobiotic Metabolism 230

    Neurobiology 239Alzheimers and Neurodegenerative

    Disease Research 239Pharmacologicals 242

    Neurotransmission 265Neuropeptides 265Neurotransmitters 272Neurotransmitter Metabolism 350

    Nitric Oxide and Cell Stress 357Nitric Oxide Metabolism 357Cell Stress 366Intracellular Protein Degradation 377

    Signal Transduction Research Tools 379Hypoxia Marker 379Neuronal Dyes and Tracers 379PKH Fluorescent Cell Linker Kits 379Protease Inhibitors 380

    Indexes 389Alphabetical 389Catalog Number/Hazard Information 437Trademarks 464

  • CHM-1 hydrate 8

    2-(2-fluorophenyl)-6,7-methylenedioxy-2-4-quinolonehydrate; NSC 656158C16H10FNO3 xH2O FW 283.25 (Anh)

    NH

    OO

    OF

    xH2O

    CHM-1 possess antimitotic and antiangiogenic antitumor activity.

    99% (HPLC)ship: ambient store at: room temp

    C1244-5MG 5 mg

    C1244-25MG 25 mg

    CIL-102

    1-[4-(Furo[2,3-b]quinolin-4-ylamino)phenyl]ethanone[479077764] C19H14N2O2 FW 302.33

    CIL-102 is a tubulin polymerization inhibitor: apoptosis inducer.

    95% (HPLC)

    US Patent No. 6,750,223. Sold for non-human research purposes under a non-exclusive license agreement with Kaohsiung Medical University.ship: ambient store at: room temp

    C5492-10MG 10 mg

    Clofarabine 8

    (2R,3R,4S,5R)-5-(6-amino-2-chloropurin-9-yl)-4-fluoro-2-(hydroxymethyl)oxolan-3-ol, 2-chloro-2-arabino-fluoro-2-deoxyadenosine[123318821] C10H11ClFN5O3 FW 303.68

    N

    N N

    NNH2

    O

    OH

    F

    HOCl

    Clofarabine is an antimetabolite toxic to nondividing lymphocytes andmonocytes.

    98% (HPLC)ship: ambient store at: room temp

    C7495-5MG 5 mg

    C7495-25MG 25 mg

    Combretastatin A4 8

    H3CO

    H3CO OCH3

    OH

    OCH3

    2-Methoxy-5-[(1Z)-2-(3,4,5-trimethoxyphenyl)ethenyl]phenol; CA4; 1-(3,4,5-Tri-methoxyphenyl)-2-(3-hydroxy-4-methoxyphenyl) ethane 3,4,5-trimethoxy-3-hydroxy-4-methoxystilbene[117048596] C18H20O5 FW 316.35

    Combretastatin A4 is a vascular disrupting agent (VDA) that targets tumorvasculature to inhibit angiogenesis.

    98% (HPLC)ship: ambient store at: room temp

    C7744-5MG 5 mg

    C7744-25MG 25 mg

    CP-31398 dihydrochloride hydrate 8

    N

    N

    HN

    OCH3

    2HCl xH2O

    NCH3

    CH3

    N-[2-[2-(4-Methoxyphenyl)ethenyl]-4-quinazolinyl]-N,N-dimethyl-1,3-propanedi-amine dihydrochloride hydrateC22H26N4O2HCl xH2O FW 435.39 (Anh)

    CP-31398 dihyrochloride hydrate is a p53 stabilizer; apoptosis inducer.

    98% (HPLC)

    Sold for research purposes under agreement from Pfizer Inc.ship: ambient store at: room temp

    PZ0115-5MG 5 mg

    PZ0115-25MG 25 mg

    Darinaparsin 8

    NH2HO

    O

    HN

    ONH

    OOH

    OSAs CH3H3C

    L--Glutamyl-S-(dimethylarsanyl)-L-cysteinylglycine; S-dimethylarsino-glutathione[69819869] C12H22AsN3O6S FW 411.31

    Darinaparsin is a antineoplastic organic arsenic.

    95% (HPLC)ship: ambient store at: room temp

    D2071-5MG 5 mg

    D2071-25MG 25 mg

    DMXAA

    5,6-Dimethylxanthenone-4-acetic Acid; ASA404; Vadimezan[117570533] C17H14O4 FW 282.29

    DMXAA is an apoptosis inducer; anti-vascular.

    98% (HPLC)ship: ambient store at: room temp

    D5817-5MG 5 mg

    D5817-25MG 25 mg

    EF-24 8

    F

    NH

    FO

    HCl

    (3E,5E)-3,5-bis[(2-fluorophenyl)methylene]-4-piperidinone[342808406] C19H15F2NO FW 311.33

    EF-24 is an IKK inhibitor and curcumin analog. EF-24 is more potent andbioavailable than curcumin, with 10-fold greater potency in cell deathinduction.

    Apoptosis and Cell CycleApoptosis Inducers

    Extract Data: #2393, SMC Pg Count File UNP 1215b

    42 General Information

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  • 98% (HPLC)ship: ambient store at: room temp

    E8409-5MG 5 mg

    E8409-25MG 25 mg

    Erastin 8

    2-[1-[4-[2-(4-Chlorophenoxy)acetyl]-1-piperazinyl]ethyl]-3-(2-ethoxyphenyl)-4(3H)-Quinazolinone[571203786] C30H31ClN4O4 FW 547.04

    N

    O

    NN

    O

    CH3

    NO O

    Cl

    CH3

    Erastin is an antitumor agent selective for tumor cells bearing oncogenic RAS.

    98% (HPLC)ship: ambient store at: room temp

    E7781-1MG 1 mg

    E7781-5MG 5 mg

    10058-F4 8

    S

    NH

    O SH3C

    5-[(4-Ethylphenyl)methylene]-2-thioxo-4-thiazolidinone[403811552] C12H11NOS2 FW 249.35

    10058-F4 is a c-Myc inhibitor.

    98% (HPLC)ship: ambient store at: room temp

    F3680-5MG 5 mg

    F3680-25MG 25 mg

    Fasentin 8

    N-[4-Chloro-3-(trifluoromethyl)phenyl]-3-oxobutan-amide[392721378] C11H9ClF3NO2 FW 279.64

    H3C NH

    OO ClCF3

    Fastentin is a novel of glucose uptake, GluT1 inhibitor.

    98% (HPLC)ship: ambient store at: room temp

    F5557-5MG 5 mg

    F5557-25MG 25 mg

    Gambogic acid 8

    O

    O

    OO

    O

    CH3H3C

    H3C

    CH3

    O

    OHH

    H

    H3C

    H3C

    OH

    H3C

    CH3

    Beta-Guttiferrin; B"-Guttiferrin; Cambogic acid; Guttic acid; Guttatic acid; Beta-Guttilactone; 1,51,5-Methano-1H,3H,11H-furo(3,4-G)pyrano(3,2-B)xanthene-1-crotonic acid[2752650] C38H44O8 FW 628.75

    Gambogic acid acts as a caspase activator and apoptosis inducer.

    >97% (HPLC)ship: ambient store at: room temp

    G8171-5MG 5 mg

    G8171-25MG 25 mg

    Gemcitabine hydrochloride 8

    2-Deoxy-2,2-difluorocytidine; dFdC; dFdC; dFdCyd;LY-188011; Gemzar (Lilly)[122111039] C9H11F2N3O4 HCl FW 299.66

    OH F

    FO

    N

    N

    O

    NH2

    HO HCl

    Gemcitabine is a widely used antineoplastic agent and antimetabolite.

    98% (HPLC)ship: ambient store at: room temp

    G6423-10MG 10 mg

    G6423-50MG 50 mg

    HA 14-1

    2-Amino-6-bromo--cyano-3-(ethoxycarbonyl)-4H-1-benzopyran-4-acetic acidethyl ester; Ethyl [2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)]-4H-chromene-3-carboxylateC17H17BrN2O5 FW 409.23

    HA 14-1 is a nonpeptide apoptosis inducer; Bcl-2 antagonist.

    94% (HPLC)ship: ambient store at: room temp

    H8787-5MG 5 mg

    H8787-25MG 25 mg

    Muristerone A

    MurA; 2,3,5,11,14,20R,22R-Heptahydroxycholest-7-en-6-oneC27H44O8

    Muristerone A is a native phytosteroid known to have insecticidal properties.Induces apoptosis in cell transfected with wild-type Bax and ecdysone-inducible gene expression systems in mammalian cells and transgenicanimals.

    90%ship: ambient store at: room temp

    M7888-1MG 1 mg

    Apoptosis and Cell CycleApoptosis Inducers

    Extract Data: #2393, SMC Pg Count File UNP 1215b

    53 General Information

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  • CHM-1 hydrate 8

    2-(2-fluorophenyl)-6,7-methylenedioxy-2-4-quinolonehydrate; NSC 656158C16H10FNO3 xH2O FW 283.25 (Anh)

    NH

    OO

    OF

    xH2O

    CHM-1 possess antimitotic and antiangiogenic antitumor activity.

    99% (HPLC)ship: ambient store at: room temp

    C1244-5MG 5 mg

    C1244-25MG 25 mg

    CIL-102

    1-[4-(Furo[2,3-b]quinolin-4-ylamino)phenyl]ethanone[479077764] C19H14N2O2 FW 302.33

    CIL-102 is a tubulin polymerization inhibitor: apoptosis inducer.

    95% (HPLC)

    US Patent No. 6,750,223. Sold for non-human research purposes under a non-exclusive license agreement with Kaohsiung Medical University.ship: ambient store at: room temp

    C5492-10MG 10 mg

    Clofarabine 8

    (2R,3R,4S,5R)-5-(6-amino-2-chloropurin-9-yl)-4-fluoro-2-(hydroxymethyl)oxolan-3-ol, 2-chloro-2-arabino-fluoro-2-deoxyadenosine[123318821] C10H11ClFN5O3 FW 303.68

    N

    N N

    NNH2

    O

    OH

    F

    HOCl

    Clofarabine is an antimetabolite toxic to nondividing lymphocytes andmonocytes.

    98% (HPLC)ship: ambient store at: room temp

    C7495-5MG 5 mg

    C7495-25MG 25 mg

    Combretastatin A4 8

    H3CO

    H3CO OCH3

    OH

    OCH3

    2-Methoxy-5-[(1Z)-2-(3,4,5-trimethoxyphenyl)ethenyl]phenol; CA4; 1-(3,4,5-Tri-methoxyphenyl)-2-(3-hydroxy-4-methoxyphenyl) ethane 3,4,5-trimethoxy-3-hydroxy-4-methoxystilbene[117048596] C18H20O5 FW 316.35

    Combretastatin A4 is a vascular disrupting agent (VDA) that targets tumorvasculature to inhibit angiogenesis.

    98% (HPLC)ship: ambient store at: room temp

    C7744-5MG 5 mg

    C7744-25MG 25 mg

    CP-31398 dihydrochloride hydrate 8

    N

    N

    HN

    OCH3

    2HCl xH2O

    NCH3

    CH3

    N-[2-[2-(4-Methoxyphenyl)ethenyl]-4-quinazolinyl]-N,N-dimethyl-1,3-propanedi-amine dihydrochloride hydrateC22H26N4O2HCl xH2O FW 435.39 (Anh)

    CP-31398 dihyrochloride hydrate is a p53 stabilizer; apoptosis inducer.

    98% (HPLC)

    Sold for research purposes under agreement from Pfizer Inc.ship: ambient store at: room temp

    PZ0115-5MG 5 mg

    PZ0115-25MG 25 mg

    Darinaparsin 8

    NH2HO

    O

    HN

    ONH

    OOH

    OSAs CH3H3C

    L--Glutamyl-S-(dimethylarsanyl)-L-cysteinylglycine; S-dimethylarsino-glutathione[69819869] C12H22AsN3O6S FW 411.31

    Darinaparsin is a antineoplastic organic arsenic.

    95% (HPLC)ship: ambient store at: room temp

    D2071-5MG 5 mg

    D2071-25MG 25 mg

    DMXAA

    5,6-Dimethylxanthenone-4-acetic Acid; ASA404; Vadimezan[117570533] C17H14O4 FW 282.29

    DMXAA is an apoptosis inducer; anti-vascular.

    98% (HPLC)ship: ambient store at: room temp

    D5817-5MG 5 mg

    D5817-25MG 25 mg

    EF-24 8

    F

    NH

    FO

    HCl

    (3E,5E)-3,5-bis[(2-fluorophenyl)methylene]-4-piperidinone[342808406] C19H15F2NO FW 311.33

    EF-24 is an IKK inhibitor and curcumin analog. EF-24 is more potent andbioavailable than curcumin, with 10-fold greater potency in cell deathinduction.

    Apoptosis and Cell CycleApoptosis Inducers

    Extract Data: #2393, SMC Pg Count File UNP 1215b

    44 Licensing Requirements

    Sale of Controlled Substances: United States

    Fill in todays date Fill in the name of supplier as Sigma-Aldrich, Inc ,

    3050 Spruce, St Louis, MO 63103

    Fill in columns marked No of Packages, Size of Package, and Name of Item Use only one line per item ordered

    Fill in No of lines completed

    Supplied by the DEA Do not change Supplied by the DEA Do not change Sign with your Authorized Signature Do not fill in For Supplier use only

    Instructions appear on the back of the form Keep the blue copy and send the tan and green copy and carbons to supplier (Sigma-Aldrich, Inc )

    Orders for controlled substances can be purchased by internet ordering at sigma-aldrich.com or in writing and are available only to those licensed by the Drug Enforcement Administration (DEA) For information on obtaining a DEA license, visit www.DEAdiversion.usdoj.gov or contact your local DEA Office Telephone orders cannot be accepted

    Initial orders for all controlled substances must be accompanied by a photocopy of your institutions Federal Registration Form 223 (see adjacent column) We will keep this copy in our files for reference in filling future orders To prevent delays in shipment, please ensure that our copy of your license is current and reference this license number on all DEA purchase orders

    your written purchase order must include:

    A) Your DEA registration number

    B) The ship to address must exactly correspond to your name and address on the DEA registration

    C) A $60 00 administrative fee is charged to cover the special handling and paperwork required by the DEA The charge is the same, regardless of the number of items on the order Please include this line item on your purchase order

    Orders for Schedule I and II items must also include a completed DEA Form 222 (see sample below) Schedule numbers for these products are listed on the following pages Sigma-Aldrichs name and address must appear exactly as shown in the example below Product names must appear exactly as listed in this catalog We cannot fill an order submitted on an altered or incomplete form. erasures, typeovers, or use of whiteout will invalidate the 222 form. If your name and address have changed, contact your local DEA office immediately Shipment will be made only to the address printed on the form

  • 98% (HPLC)ship: ambient store at: room temp

    E8409-5MG 5 mg

    E8409-25MG 25 mg

    Erastin 8

    2-[1-[4-[2-(4-Chlorophenoxy)acetyl]-1-piperazinyl]ethyl]-3-(2-ethoxyphenyl)-4(3H)-Quinazolinone[571203786] C30H31ClN4O4 FW 547.04

    N

    O

    NN

    O

    CH3

    NO O

    Cl

    CH3

    Erastin is an antitumor agent selective for tumor cells bearing oncogenic RAS.

    98% (HPLC)ship: ambient store at: room temp

    E7781-1MG 1 mg

    E7781-5MG 5 mg

    10058-F4 8

    S

    NH

    O SH3C

    5-[(4-Ethylphenyl)methylene]-2-thioxo-4-thiazolidinone[403811552] C12H11NOS2 FW 249.35

    10058-F4 is a c-Myc inhibitor.

    98% (HPLC)ship: ambient store at: room temp

    F3680-5MG 5 mg

    F3680-25MG 25 mg

    Fasentin 8

    N-[4-Chloro-3-(trifluoromethyl)phenyl]-3-oxobutan-amide[392721378] C11H9ClF3NO2 FW 279.64

    H3C NH

    OO ClCF3

    Fastentin is a novel of glucose uptake, GluT1 inhibitor.

    98% (HPLC)ship: ambient store at: room temp

    F5557-5MG 5 mg

    F5557-25MG 25 mg

    Gambogic acid 8

    O

    O

    OO

    O

    CH3H3C

    H3C

    CH3

    O

    OHH

    H

    H3C

    H3C

    OH

    H3C

    CH3

    Beta-Guttiferrin; B"-Guttiferrin; Cambogic acid; Guttic acid; Guttatic acid; Beta-Guttilactone; 1,51,5-Methano-1H,3H,11H-furo(3,4-G)pyrano(3,2-B)xanthene-1-crotonic acid[2752650] C38H44O8 FW 628.75

    Gambogic acid acts as a caspase activator and apoptosis inducer.

    >97% (HPLC)ship: ambient store at: room temp

    G8171-5MG 5 mg

    G8171-25MG 25 mg

    Gemcitabine hydrochloride 8

    2-Deoxy-2,2-difluorocytidine; dFdC; dFdC; dFdCyd;LY-188011; Gemzar (Lilly)[122111039] C9H11F2N3O4 HCl FW 299.66

    OH F

    FO

    N

    N

    O

    NH2

    HO HCl

    Gemcitabine is a widely used antineoplastic agent and antimetabolite.

    98% (HPLC)ship: ambient store at: room temp

    G6423-10MG 10 mg

    G6423-50MG 50 mg

    HA 14-1

    2-Amino-6-bromo--cyano-3-(ethoxycarbonyl)-4H-1-benzopyran-4-acetic acidethyl ester; Ethyl [2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)]-4H-chromene-3-carboxylateC17H17BrN2O5 FW 409.23

    HA 14-1 is a nonpeptide apoptosis inducer; Bcl-2 antagonist.

    94% (HPLC)ship: ambient store at: room temp

    H8787-5MG 5 mg

    H8787-25MG 25 mg

    Muristerone A

    MurA; 2,3,5,11,14,20R,22R-Heptahydroxycholest-7-en-6-oneC27H44O8

    Muristerone A is a native phytosteroid known to have insecticidal properties.Induces apoptosis in cell transfected with wild-type Bax and ecdysone-inducible gene expression systems in mammalian cells and transgenicanimals.

    90%ship: ambient store at: room temp

    M7888-1MG 1 mg

    Apoptosis and Cell CycleApoptosis Inducers

    Extract Data: #2393, SMC Pg Count File UNP 1215b

    55 Licensing Requirements

    DEA Controlled Substances Classes IVItems marked () may not be exported from the USA

    Cat. NodeA Class

    Name

    A5880 II d-AmphetamineA7755 III 5-Androstane-3,17-diolA8380 III 5-Androstan-17-ol-3-oneA8800 IV AlprazolamB159 I ()-1-(4-Bromo-2,5-dimethoxyphenyl)-2-ethanamineB8263 III BenzphetamineB9156 IV ButorphanolB9275 III BuprenorphineC124 II -CFT naphthalenedisulfonateC1277 IV ClonazepamC155 II ()-2-Carbomethoxy-3-(4-iodophenyl)nortropaneC222 IV CathineC2517 IV ChlordiazepoxideC3196 I S()-CathinoneC5776 II CocaineC8383 IV ChloralC8414 IV ClobazamC8912 II CocaineD0899 IV DiazepamD7412 I ()-2,5-Dimethoxy-4-bromoamphetamineE3638 IV EstazolamE8512 II EthylmorphineF103 IV FlurazepamF112 IV (+)-FenfluramineF3886 II FentanylF7751 III FluoxymesteroneF8507 IV ()-FenfluramineF9261 IV FlunitrazepamH2898 III 6-HydroxytestosteroneH3635 I -Hydroxybutyric acidH4128 III 11-HydroxytestosteroneH4516 II HydrocodoneH5136 II HydromorphoneH7909 I HU-210J2753 I JWH-133K113 III Ketamine hydrochloride/xylazine hydrochlorideK1884 III S-(+)-KetamineK2753 III ()-KetamineK8250 III 11-KetotestosteroneL1764 IV ()-LorazepamL5143 II LevorphanolL7007 I Lysergic acid diethylamideL7418 II LAAMM0267 II ()-MethadoneM139 I S(+)-3,4-MethylenedioxymethamphetamineM1796 I ()-3,4-Methylenedioxy-N- ethyl amphetamineM200 I ()-N-Methyl-1-(3,4-methylenedioxyphenyl)-2-

    butanamine

    M2017 IV Mazindol

    Cat. NodeA Class

    Name

    M2419 IV MidazolamM2892 II MethylphenidateM3142 II MeperidineM3404 I ()-p-MethoxyamphetamineM3528 II Morphine 6--d-glucuronideM5037 I 2-(Methylamino)propiophenoneM6267 I ()-3,4-MethylenedioxyamphetamineM6403 I ()-3,4-MethylenedioxymethamphetamineM6810 II d-threo-MethylphenidateM6935 II l-threo-MethylphenidateM6940 IV ModafinilM7252 III 17-MethyltestosteroneM8750 II (+)-MethamphetamineM8777 II MorphineN100 III NalorphineN3785 II NabiloneN3889 IV NitrazepamO5254 IV OxazepamP127 IV (+)-PentazocineP2279 I PsilocinP3029 II PhencyclidineP3654 IV PrazepamP3761 II PentobarbitalP5178 IV PhenobarbitalP5520 IV ParaldehydePZ0010 V PregabalinR0908 IIIN R1881S9944 IV SibutramineT133 III InactinT1500 III TestosteroneT1875 III Testosterone propionateT2000 III Testosterone -d-glucuronideT2019 II ThebaineT2386 I 9-TetrahydrocannabinolT8157 III Testosterone -d-glucuronideT9772 IV TriazolamUC161 II Morphine-3,6-diglucuronide tetrahydrateUC282 III 6-HydroxytestosteroneUC429 IV MidazolamZ0502 IV ZaleplonZ103 IV ZolpidemZ4900 IV ZopicloneC5901 II CodeineC6888 I CannabinolD7282 IV DesmethyldiazepamM3637 I MethaqualoneN2144 IV NorfludiazepamO0380 III Oxymetholone

  • CHM-1 hydrate 8

    2-(2-fluorophenyl)-6,7-methylenedioxy-2-4-quinolonehydrate; NSC 656158C16H10FNO3 xH2O FW 283.25 (Anh)

    NH

    OO

    OF

    xH2O

    CHM-1 possess antimitotic and antiangiogenic antitumor activity.

    99% (HPLC)ship: ambient store at: room temp

    C1244-5MG 5 mg

    C1244-25MG 25 mg

    CIL-102

    1-[4-(Furo[2,3-b]quinolin-4-ylamino)phenyl]ethanone[479077764] C19H14N2O2 FW 302.33

    CIL-102 is a tubulin polymerization inhibitor: apoptosis inducer.

    95% (HPLC)

    US Patent No. 6,750,223. Sold for non-human research purposes under a non-exclusive license agreement with Kaohsiung Medical University.ship: ambient store at: room temp

    C5492-10MG 10 mg

    Clofarabine 8

    (2R,3R,4S,5R)-5-(6-amino-2-chloropurin-9-yl)-4-fluoro-2-(hydroxymethyl)oxolan-3-ol, 2-chloro-2-arabino-fluoro-2-deoxyadenosine[123318821] C10H11ClFN5O3 FW 303.68

    N

    N N

    NNH2

    O

    OH

    F

    HOCl

    Clofarabine is an antimetabolite toxic to nondividing lymphocytes andmonocytes.

    98% (HPLC)ship: ambient store at: room temp

    C7495-5MG 5 mg

    C7495-25MG 25 mg

    Combretastatin A4 8

    H3CO

    H3CO OCH3

    OH

    OCH3

    2-Methoxy-5-[(1Z)-2-(3,4,5-trimethoxyphenyl)ethenyl]phenol; CA4; 1-(3,4,5-Tri-methoxyphenyl)-2-(3-hydroxy-4-methoxyphenyl) ethane 3,4,5-trimethoxy-3-hydroxy-4-methoxystilbene[117048596] C18H20O5 FW 316.35

    Combretastatin A4 is a vascular disrupting agent (VDA) that targets tumorvasculature to inhibit angiogenesis.

    98% (HPLC)ship: ambient store at: room temp

    C7744-5MG 5 mg

    C7744-25MG 25 mg

    CP-31398 dihydrochloride hydrate 8

    N

    N

    HN

    OCH3

    2HCl xH2O

    NCH3

    CH3

    N-[2-[2-(4-Methoxyphenyl)ethenyl]-4-quinazolinyl]-N,N-dimethyl-1,3-propanedi-amine dihydrochloride hydrateC22H26N4O2HCl xH2O FW 435.39 (Anh)

    CP-31398 dihyrochloride hydrate is a p53 stabilizer; apoptosis inducer.

    98% (HPLC)

    Sold for research purposes under agreement from Pfizer Inc.ship: ambient store at: room temp

    PZ0115-5MG 5 mg

    PZ0115-25MG 25 mg

    Darinaparsin 8

    NH2HO

    O

    HN

    ONH

    OOH

    OSAs CH3H3C

    L--Glutamyl-S-(dimethylarsanyl)-L-cysteinylglycine; S-dimethylarsino-glutathione[69819869] C12H22AsN3O6S FW 411.31

    Darinaparsin is a antineoplastic organic arsenic.

    95% (HPLC)ship: ambient store at: room temp

    D2071-5MG 5 mg

    D2071-25MG 25 mg

    DMXAA

    5,6-Dimethylxanthenone-4-acetic Acid; ASA404; Vadimezan[117570533] C17H14O4 FW 282.29

    DMXAA is an apoptosis inducer; anti-vascular.

    98% (HPLC)ship: ambient store at: room temp

    D5817-5MG 5 mg

    D5817-25MG 25 mg

    EF-24 8

    F

    NH

    FO

    HCl

    (3E,5E)-3,5-bis[(2-fluorophenyl)methylene]-4-piperidinone[342808406] C19H15F2NO FW 311.33

    EF-24 is an IKK inhibitor and curcumin analog. EF-24 is more potent andbioavailable than curcumin, with 10-fold greater potency in cell deathinduction.

    Apoptosis and Cell CycleApoptosis Inducers

    Extract Data: #2393, SMC Pg Count File UNP 1215b

    46 Licensing Requirements

    Sale of Controlled Substances: United KingdomCustomer Declaration Forms and End-User StatementsCertain products or Customers require end-user declarations to be completed before we can proceed with your order

    End-use statements are required for various reasons as follows:

    they are legally required for several types of product such as Categories 1 & 2 drug precursors and ozone depletors;

    they enable orders, that legally require a written order, to be taken over the phone or internet, such as duty-free alcohol or controlled drugs;

    they are required by some countries so they can apply for an export licence, such as some dual-use products and chemical weapons materials;

    they are required for substances which are not controlled in the UK, but are controlled in other countries;

    we are not permitted to re-export some products that have been imported, such as some dual-use, chemical weapon and controlled drug products;

    they are a condition of our licence to sell patented products;they are a condition placed on us by our suppliers to ensure products are not misused, such as watch list drug precursors; and

    there are some products that, although not controlled, can be put to various inappropriate uses and we wish to ensure that this possibility is reduced

    All forms are listed below and are available from our UK website Our Customer Services Team will advise on the required form at the time of your order The completed form must be returned to us as described within the body of the form Please fax your completed forms to 01747 833569

    Form A Customer Declaration of Specific Use(s) of the Sched-uled Category 1 or 2 Drug Precursors

    Form B Customer Declaration Under The Chemicals Weapons Act 1996

    Form D End-User Statement Exporting Country RequirementForm E End-User Information U S RequirementForm G GMO IRMM Certified Reference Material Destination

    Information EC RequirementForm H Ozone Depletor End-User Statement EC RegulationForm J Home Office Licence Detailed end-user statement in

    accordance with Misuse of Drugs Regulations 2001 Form K End-User Information Customer Intra-organisation

    exportForm L End-User Information Customer Intra-site transfer

    within UKForm M End-User Information Duty-Free Spirit Declaration

    HM Revenue & CustomsForm N GMO Centre RegistrationForm R Software Registration Form for AldrichForm U End-User Statement General

  • 98% (HPLC)ship: ambient store at: room temp

    E8409-5MG 5 mg

    E8409-25MG 25 mg

    Erastin 8

    2-[1-[4-[2-(4-Chlorophenoxy)acetyl]-1-piperazinyl]ethyl]-3-(2-ethoxyphenyl)-4(3H)-Quinazolinone[571203786] C30H31ClN4O4 FW 547.04

    N

    O

    NN

    O

    CH3

    NO O

    Cl

    CH3

    Erastin is an antitumor agent selective for tumor cells bearing oncogenic RAS.

    98% (HPLC)ship: ambient store at: room temp

    E7781-1MG 1 mg

    E7781-5MG 5 mg

    10058-F4 8

    S

    NH

    O SH3C

    5-[(4-Ethylphenyl)methylene]-2-thioxo-4-thiazolidinone[403811552] C12H11NOS2 FW 249.35

    10058-F4 is a c-Myc inhibitor.

    98% (HPLC)ship: ambient store at: room temp

    F3680-5MG 5 mg

    F3680-25MG 25 mg

    Fasentin 8

    N-[4-Chloro-3-(trifluoromethyl)phenyl]-3-oxobutan-amide[392721378] C11H9ClF3NO2 FW 279.64

    H3C NH

    OO ClCF3

    Fastentin is a novel of glucose uptake, GluT1 inhibitor.

    98% (HPLC)ship: ambient store at: room temp

    F5557-5MG 5 mg

    F5557-25MG 25 mg

    Gambogic acid 8

    O

    O

    OO

    O

    CH3H3C

    H3C

    CH3

    O

    OHH

    H

    H3C

    H3C

    OH

    H3C

    CH3

    Beta-Guttiferrin; B"-Guttiferrin; Cambogic acid; Guttic acid; Guttatic acid; Beta-Guttilactone; 1,51,5-Methano-1H,3H,11H-furo(3,4-G)pyrano(3,2-B)xanthene-1-crotonic acid[2752650] C38H44O8 FW 628.75

    Gambogic acid acts as a caspase activator and apoptosis inducer.

    >97% (HPLC)ship: ambient store at: room temp

    G8171-5MG 5 mg

    G8171-25MG 25 mg

    Gemcitabine hydrochloride 8

    2-Deoxy-2,2-difluorocytidine; dFdC; dFdC; dFdCyd;LY-188011; Gemzar (Lilly)[122111039] C9H11F2N3O4 HCl FW 299.66

    OH F

    FO

    N

    N

    O

    NH2

    HO HCl

    Gemcitabine is a widely used antineoplastic agent and antimetabolite.

    98% (HPLC)ship: ambient store at: room temp

    G6423-10MG 10 mg

    G6423-50MG 50 mg

    HA 14-1

    2-Amino-6-bromo--cyano-3-(ethoxycarbonyl)-4H-1-benzopyran-4-acetic acidethyl ester; Ethyl [2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)]-4H-chromene-3-carboxylateC17H17BrN2O5 FW 409.23

    HA 14-1 is a nonpeptide apoptosis inducer; Bcl-2 antagonist.

    94% (HPLC)ship: ambient store at: room temp

    H8787-5MG 5 mg

    H8787-25MG 25 mg

    Muristerone A

    MurA; 2,3,5,11,14,20R,22R-Heptahydroxycholest-7-en-6-oneC27H44O8

    Muristerone A is a native phytosteroid known to have insecticidal properties.Induces apoptosis in cell transfected with wild-type Bax and ecdysone-inducible gene expression systems in mammalian cells and transgenicanimals.

    90%ship: ambient store at: room temp

    M7888-1MG 1 mg

    Apoptosis and Cell CycleApoptosis Inducers

    Extract Data: #2393, SMC Pg Count File UNP 1215b

    57 Licensing Requirements

    Home Office Schedule Reference Guide

    Cat. No.

    home Office

    Schedule Name

    A5880 2 d-AmphetamineA7755 4 2 5-Androstane-3,17-diolA8380 4 2 5-Androstan-17-ol-3-oneA8800 4 1 AlprazolamB159 1 ()-1-(4-Bromo-2,5-dimethoxyphenyl)-2-

    ethanamine

    B8263 3 BenzphetamineB9275 3 BuprenorphineC1277 4 1 ClonazepamC155 2 ()-2-Carbomethoxy-3-(4-iodophenyl)

    nortropane

    C222 3 CathineC2517 4 1 ChlordiazepoxideC3196 1 S()-CathinoneC5423 4 2 ClenbuterolC5776 2 CocaineC5901 2 CodeineC6888 1 CannabinolC8414 4 1 ClobazamC8912 2 CocaineC9635 1 dl-p-ChloroamphetamineD0899 4 1 DiazepamD101 1 ()-DOID153 1 (R)()-DOID5297 4 2 Dehydroisoandrosterone 3-sulfateD7282 4 1 DesmethyldiazepamD7412 1 ()-2,5-Dimethoxy-4-bromoamphetamineE3638 4 1 EstazolamE5878 4 2 EpitestosteroneE8512 2 EthylmorphineF103 4 1 FlurazepamF3886 2 FentanylF7751 4 2 FluoxymesteroneF9261 3 FlunitrazepamH2898 4 2 6-HydroxytestosteroneH3132 1 3-Hydroxy-4-methoxyphenethylamineH3635 4 1 -Hydroxybutyric acidH4128 4 2 11-HydroxytestosteroneH4516 2 HydrocodoneH5136 2 HydromorphoneJ2753 1 JWH-133K8250 4 2 11-KetotestosteroneL1764 4 1 ()-LorazepamL5143 2 LevorphanolL7007 1 Lysergic acid diethylamide

    Cat. No.

    home Office

    Schedule Name

    M0267 2 ()-MethadoneM139 1 S(+)-3,4-MethylenedioxymethamphetamineM1796 1 ()-3,4-Methylenedioxy-N- ethyl amphetamineM200 1 ()-N-Methyl-1-(3,4-methylenedioxyphenyl)-2-

    butanamine

    M2017 3 MazindolM2381 1 5-Methoxy-N,N-dimethyltryptamineM2419 3 MidazolamM2892 2 MethylphenidateM3142 2 MeperidineM3404 1 ()-p-MethoxyamphetamineM3528 2 Morphine 6--d-glucuronideM3637 2 MethaqualoneM4251 1 3-MethoxytyramineM5037 1 2-(Methylamino)propiophenoneM6267 1 ()-3,4-MethylenedioxyamphetamineM6403 1 ()-3,4-MethylenedioxymethamphetamineM6810 2 d-threo-MethylphenidateM6935 2 l-threo-MethylphenidateM7252 4 2 17-MethyltestosteroneM8750 2 (+)-MethamphetamineM8777 2 MorphineN2144 4 1 NorfludiazepamN3889 4 1 NitrazepamO0380 4 2 OxymetholoneO5254 4 1 OxazepamP127 3 (+)-PentazocineP2279 1 PsilocinP3029 2 PhencyclidineP3654 4 1 PrazepamP3761 3 PentobarbitalP5178 3 PhenobarbitalR0908 4 2 R1881 (Metribolone)T1500 4 2 TestosteroneT1875 4 2 Testosterone propionateT2000 4 2 Testosterone -d-glucuronideT2019 2 ThebaineT2386 2 9-TetrahydrocannabinolT4764 2 9-TetrahydrocannabinolT8157 4 2 Testosterone -d-glucuronideT8390 4 2 Testosterone 3-(O-carboxymethyl)oximeT9772 4 1 TriazolamUC282 4 2 6-HydroxytestosteroneUC429 3 MidazolamZ103 4 1 Zolpidem

  • CHM-1 hydrate 8

    2-(2-fluorophenyl)-6,7-methylenedioxy-2-4-quinolonehydrate; NSC 656158C16H10FNO3 xH2O FW 283.25 (Anh)

    NH

    OO

    OF

    xH2O

    CHM-1 possess antimitotic and antiangiogenic antitumor activity.

    99% (HPLC)ship: ambient store at: room temp

    C1244-5MG 5 mg

    C1244-25MG 25 mg

    CIL-102

    1-[4-(Furo[2,3-b]quinolin-4-ylamino)phenyl]ethanone[479077764] C19H14N2O2 FW 302.33

    CIL-102 is a tubulin polymerization inhibitor: apoptosis inducer.

    95% (HPLC)

    US Patent No. 6,750,223. Sold for non-human research purposes under a non-exclusive license agreement with Kaohsiung Medical University.ship: ambient store at: room temp

    C5492-10MG 10 mg

    Clofarabine 8

    (2R,3R,4S,5R)-5-(6-amino-2-chloropurin-9-yl)-4-fluoro-2-(hydroxymethyl)oxolan-3-ol, 2-chloro-2-arabino-fluoro-2-deoxyadenosine[123318821] C10H11ClFN5O3 FW 303.68

    N

    N N

    NNH2

    O

    OH

    F

    HOCl

    Clofarabine is an antimetabolite toxic to nondividing lymphocytes andmonocytes.

    98% (HPLC)ship: ambient store at: room temp

    C7495-5MG 5 mg

    C7495-25MG 25 mg

    Combretastatin A4 8

    H3CO

    H3CO OCH3

    OH

    OCH3

    2-Methoxy-5-[(1Z)-2-(3,4,5-trimethoxyphenyl)ethenyl]phenol; CA4; 1-(3,4,5-Tri-methoxyphenyl)-2-(3-hydroxy-4-methoxyphenyl) ethane 3,4,5-trimethoxy-3-hydroxy-4-methoxystilbene[117048596] C18H20O5 FW 316.35

    Combretastatin A4 is a vascular disrupting agent (VDA) that targets tumorvasculature to inhibit angiogenesis.

    98% (HPLC)ship: ambient store at: room temp

    C7744-5MG 5 mg

    C7744-25MG 25 mg

    CP-31398 dihydrochloride hydrate 8

    N

    N

    HN

    OCH3

    2HCl xH2O

    NCH3

    CH3

    N-[2-[2-(4-Methoxyphenyl)ethenyl]-4-quinazolinyl]-N,N-dimethyl-1,3-propanedi-amine dihydrochloride hydrateC22H26N4O2HCl xH2O FW 435.39 (Anh)

    CP-31398 dihyrochloride hydrate is a p53 stabilizer; apoptosis inducer.

    98% (HPLC)

    Sold for research purposes under agreement from Pfizer Inc.ship: ambient store at: room temp

    PZ0115-5MG 5 mg

    PZ0115-25MG 25 mg

    Darinaparsin 8

    NH2HO

    O

    HN

    ONH

    OOH

    OSAs CH3H3C

    L--Glutamyl-S-(dimethylarsanyl)-L-cysteinylglycine; S-dimethylarsino-glutathione[69819869] C12H22AsN3O6S FW 411.31

    Darinaparsin is a antineoplastic organic arsenic.

    95% (HPLC)ship: ambient store at: room temp

    D2071-5MG 5 mg

    D2071-25MG 25 mg

    DMXAA

    5,6-Dimethylxanthenone-4-acetic Acid; ASA404; Vadimezan[117570533] C17H14O4 FW 282.29

    DMXAA is an apoptosis inducer; anti-vascular.

    98% (HPLC)ship: ambient store at: room temp

    D5817-5MG 5 mg

    D5817-25MG 25 mg

    EF-24 8

    F

    NH

    FO

    HCl

    (3E,5E)-3,5-bis[(2-fluorophenyl)methylene]-4-piperidinone[342808406] C19H15F2NO FW 311.33

    EF-24 is an IKK inhibitor and curcumin analog. EF-24 is more potent andbioavailable than curcumin, with 10-fold greater potency in cell deathinduction.

    Apoptosis and Cell CycleApoptosis Inducers

    Extract Data: #2393, SMC Pg Count File UNP 1215b

    48 Licensing Requirements

    Licensing and Ordering Requirements for Controlled Substances: IrelandSubstances listed in Schedules 1-4 of the Misuse of Drugs Regula-tions, 1988, (as amended), are available to users licensed by the Irish Medicines Board For your convenience, these compounds are listed on the following pages with their appropriate number

    Telephone and internet orders cannot be accepted for these items To help ensure the prompt processing of your order, please follow these instructions:

    1 Always send a written order Telephone or Internet orders cannot be accepted

    2 Your written order should (a) state the purpose for which the controlled substance is required and (b) be signed by the person in charge of the laboratory

    3 You must furnish a copy of your Irish Medicines Board licence (a photocopy will suffice) for our inspection when ordering a Schedule 1 controlled substance

    4 You must furnish a copy of your licence or authority for our inspection when ordering controlled substances falling within Schedules 2, 3 or 4 unless you are a facility falling within the scope of Regulation 8 (Supply in hospitals, etc ), such as a university, public authority hospital or approved governmental department

    Please note the following conditions:

    1 All products listed on the following pages are imported from Sigma-Aldrich offices, in various countries, against individual customer orders Many products that are not controlled in the R O I are controlled in the exporting country Written orders and further documentation may be required so the exporting country can obtain an export licence A fee of 68 will be applied when ordering such chemicals due to the level of documenta-tion required

    2 Due to the conditions of the originating countrys export licence, we cannot supply these products for onward export by our customer If you wish to supply to your customer or facility in another country, please ask your final user to contact their local Sigma-Aldrich office

  • 98% (HPLC)ship: ambient store at: room temp

    E8409-5MG 5 mg

    E8409-25MG 25 mg

    Erastin 8

    2-[1-[4-[2-(4-Chlorophenoxy)acetyl]-1-piperazinyl]ethyl]-3-(2-ethoxyphenyl)-4(3H)-Quinazolinone[571203786] C30H31ClN4O4 FW 547.04

    N

    O

    NN

    O

    CH3

    NO O

    Cl

    CH3

    Erastin is an antitumor agent selective for tumor cells bearing oncogenic RAS.

    98% (HPLC)ship: ambient store at: room temp

    E7781-1MG 1 mg

    E7781-5MG 5 mg

    10058-F4 8

    S

    NH

    O SH3C

    5-[(4-Ethylphenyl)methylene]-2-thioxo-4-thiazolidinone[403811552] C12H11NOS2 FW 249.35

    10058-F4 is a c-Myc inhibitor.

    98% (HPLC)ship: ambient store at: room temp

    F3680-5MG 5 mg

    F3680-25MG 25 mg

    Fasentin 8

    N-[4-Chloro-3-(trifluoromethyl)phenyl]-3-oxobutan-amide[392721378] C11H9ClF3NO2 FW 279.64

    H3C NH

    OO ClCF3

    Fastentin is a novel of glucose uptake, GluT1 inhibitor.

    98% (HPLC)ship: ambient store at: room temp

    F5557-5MG 5 mg

    F5557-25MG 25 mg

    Gambogic acid 8

    O

    O

    OO

    O

    CH3H3C

    H3C

    CH3

    O

    OHH

    H

    H3C

    H3C

    OH

    H3C

    CH3

    Beta-Guttiferrin; B"-Guttiferrin; Cambogic acid; Guttic acid; Guttatic acid; Beta-Guttilactone; 1,51,5-Methano-1H,3H,11H-furo(3,4-G)pyrano(3,2-B)xanthene-1-crotonic acid[2752650] C38H44O8 FW 628.75

    Gambogic acid acts as a caspase activator and apoptosis inducer.

    >97% (HPLC)ship: ambient store at: room temp

    G8171-5MG 5 mg

    G8171-25MG 25 mg

    Gemcitabine hydrochloride 8

    2-Deoxy-2,2-difluorocytidine; dFdC; dFdC; dFdCyd;LY-188011; Gemzar (Lilly)[122111039] C9H11F2N3O4 HCl FW 299.66

    OH F

    FO

    N

    N

    O

    NH2

    HO HCl

    Gemcitabine is a widely used antineoplastic agent and antimetabolite.

    98% (HPLC)ship: ambient store at: room temp

    G6423-10MG 10 mg

    G6423-50MG 50 mg

    HA 14-1

    2-Amino-6-bromo--cyano-3-(ethoxycarbonyl)-4H-1-benzopyran-4-acetic acidethyl ester; Ethyl [2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)]-4H-chromene-3-carboxylateC17H17BrN2O5 FW 409.23

    HA 14-1 is a nonpeptide apoptosis inducer; Bcl-2 antagonist.

    94% (HPLC)ship: ambient store at: room temp

    H8787-5MG 5 mg

    H8787-25MG 25 mg

    Muristerone A

    MurA; 2,3,5,11,14,20R,22R-Heptahydroxycholest-7-en-6-oneC27H44O8

    Muristerone A is a native phytosteroid known to have insecticidal properties.Induces apoptosis in cell transfected with wild-type Bax and ecdysone-inducible gene expression systems in mammalian cells and transgenicanimals.

    90%ship: ambient store at: room temp

    M7888-1MG 1 mg

    Apoptosis and Cell CycleApoptosis Inducers

    Extract Data: #2393, SMC Pg Count File UNP 1215b

    59 Licensing Requirements

    Irish Medicines Board Schedule Reference Guide

    Cat. No.

    homeOffice

    Schedule Name

    A8800 4 AlprazolamA5880 2 d-AmphetamineB8263 2 BenzphetamineB9156 2 ButorphanolB9275 2 BuprenorphineC1277 4 ClonazepamC155 2 ()-2-Carbomethoxy-3-(4-iodophenyl)

    nortropane

    C222 3 CathineC2517 4 ChlordiazepoxideC3196 1 S()-CathinoneC5776 2 CocaineC8414 4 ClobazamC8912 2 CocaineC9635 1 dl-p-ChloroamphetamineD0899 4 DiazepamD101 1 ()-DOID153 1 (R)()-DOID7412 1 ()-2,5-Dimethoxy-4-bromoamphetamineE3638 4 EstazolamE8512 2 EthylmorphineF103 4 FlurazepamF3886 2 FentanylF9261 3 FlunitrazepamH3132 1 3-Hydroxy-4-methoxyphenethylamineH3635 3 -Hydroxybutyric acidH4516 2 HydrocodoneH5136 2 HydromorphoneJ2753 1 JWH-133L1764 4 ()-LorazepamL5143 2 LevorphanolL7007 1 Lysergic acid diethylamideM0267 2 ()-MethadoneM139 1 S(+)-3,4-MethylenedioxymethamphetamineM1796 1 ()-3,4-Methylenedioxy-N- ethyl amphetamineM200 1 ()-N-Methyl-1-(3,4-methylenedioxyphenyl)-2-

    butanamine

    Cat. No.

    homeOffice

    Schedule Name

    M2017 3 MazindolM2381 1 5-Methoxy-N,N-dimethyltryptamineM2419 4 MidazolamM2892 2 MethylphenidateM3142 2 MeperidineM3404 1 ()-p-MethoxyamphetamineM3528 2 Morphine 6--d-glucuronideM4251 1 3-MethoxytyramineM5037 1 2-(Methylamino)propiophenoneM6267 1 ()-3,4-MethylenedioxyamphetamineM6403 1 ()-3,4-MethylenedioxymethamphetamineM6810 2 d-threo-MethylphenidateM6935 2 l-threo-MethylphenidateM8750 2 (+)-MethamphetamineM8777 2 MorphineN3889 4 NitrazepamO5254 4 OxazepamP127 3 (+)-PentazocineP2279 1 PsilocinP3029 2 PhencyclidineP3654 4 PrazepamP3761 3 PentobarbitalP5178 3 PhenobarbitalT2019 2 ThebaineT2386 2 9-TetrahydrocannabinolT9772 4 TriazolamUC161 2 Morphine-3,6-diglucuronide tetrahydrateUC429 4 MidazolamC5901 2 CodeineC6888 1 CannabinolD7282 4 DesmethyldiazepamM3637 2 MethaqualoneN2144 4 NorfludiazepamT4764 2 9-Tetrahydrocannabinol

  • CHM-1 hydrate 8

    2-(2-fluorophenyl)-6,7-methylenedioxy-2-4-quinolonehydrate; NSC 656158C16H10FNO3 xH2O FW 283.25 (Anh)

    NH

    OO

    OF

    xH2O

    CHM-1 possess antimitotic and antiangiogenic antitumor activity.

    99% (HPLC)ship: ambient store at: room temp

    C1244-5MG 5 mg

    C1244-25MG 25 mg

    CIL-102

    1-[4-(Furo[2,3-b]quinolin-4-ylamino)phenyl]ethanone[479077764] C19H14N2O2 FW 302.33

    CIL-102 is a tubulin polymerization inhibitor: apoptosis inducer.

    95% (HPLC)

    US Patent No. 6,750,223. Sold for non-human research purposes under a non-exclusive license agreement with Kaohsiung Medical University.ship: ambient store at: room temp

    C5492-10MG 10 mg

    Clofarabine 8

    (2R,3R,4S,5R)-5-(6-amino-2-chloropurin-9-yl)-4-fluoro-2-(hydroxymethyl)oxolan-3-ol, 2-chloro-2-arabino-fluoro-2-deoxyadenosine[123318821] C10H11ClFN5O3 FW 303.68

    N

    N N

    NNH2

    O

    OH

    F

    HOCl

    Clofarabine is an antimetabolite toxic to nondividing lymphocytes andmonocytes.

    98% (HPLC)ship: ambient store at: room temp

    C7495-5MG 5 mg

    C7495-25MG 25 mg

    Combretastatin A4 8

    H3CO

    H3CO OCH3

    OH

    OCH3

    2-Methoxy-5-[(1Z)-2-(3,4,5-trimethoxyphenyl)ethenyl]phenol; CA4; 1-(3,4,5-Tri-methoxyphenyl)-2-(3-hydroxy-4-methoxyphenyl) ethane 3,4,5-trimethoxy-3-hydroxy-4-methoxystilbene[117048596] C18H20O5 FW 316.35

    Combretastatin A4 is a vascular disrupting agent (VDA) that targets tumorvasculature to inhibit angiogenesis.

    98% (HPLC)ship: ambient store at: room temp

    C7744-5MG 5 mg

    C7744-25MG 25 mg

    CP-31398 dihydrochloride hydrate 8

    N

    N

    HN

    OCH3

    2HCl xH2O

    NCH3

    CH3

    N-[2-[2-(4-Methoxyphenyl)ethenyl]-4-quinazolinyl]-N,N-dimethyl-1,3-propanedi-amine dihydrochloride hydrateC22H26N4O2HCl xH2O FW 435.39 (Anh)

    CP-31398 dihyrochloride hydrate is a p53 stabilizer; apoptosis inducer.

    98% (HPLC)

    Sold for research purposes under agreement from Pfizer Inc.ship: ambient store at: room temp

    PZ0115-5MG 5 mg

    PZ0115-25MG 25 mg

    Darinaparsin 8

    NH2HO

    O

    HN

    ONH

    OOH

    OSAs CH3H3C

    L--Glutamyl-S-(dimethylarsanyl)-L-cysteinylglycine; S-dimethylarsino-glutathione[69819869] C12H22AsN3O6S FW 411.31

    Darinaparsin is a antineoplastic organic arsenic.

    95% (HPLC)ship: ambient store at: room temp

    D2071-5MG 5 mg

    D2071-25MG 25 mg

    DMXAA

    5,6-Dimethylxanthenone-4-acetic Acid; ASA404; Vadimezan[117570533] C17H14O4 FW 282.29

    DMXAA is an apoptosis inducer; anti-vascular.

    98% (HPLC)ship: ambient store at: room temp

    D5817-5MG 5 mg

    D5817-25MG 25 mg

    EF-24 8

    F

    NH

    FO

    HCl

    (3E,5E)-3,5-bis[(2-fluorophenyl)methylene]-4-piperidinone[342808406] C19H15F2NO FW 311.33

    EF-24 is an IKK inhibitor and curcumin analog. EF-24 is more potent andbioavailable than curcumin, with 10-fold greater potency in cell deathinduction.

    Apoptosis and Cell CycleApoptosis Inducers

    Extract Data: #2393, SMC Pg Count File UNP 1215b

    410 Licensing Requirements

    Orders of Products Covered by the German Act on Narcotics Betubungsmittelgesetz License and Ordering Conditions: GermanyAccording to 3 of the Betubungsmittelgesetz we are obliged to receive any order from a customer in written form and to obtain a copy of the customers licence (BTM-Erlaubnis)

    We charge the customer 50 EUR,- per consignment for the expenses resulting from the import and notification procedures

    We require the order in written from and an enduser declaration since the concerned products will be ordered directly in the USA

    The estimated delivery period for these products is 8 weeks starting from the receipt of all required documents

    Concerned products are not allowed to be re-exported from Germany The delivery will happen exclusively to end-users and not to dealers

    In Austria different requirements apply to narcotics and psycho-tropic substances Please contact our customer service in Vienna on this number 01-605 81 10

  • 98% (HPLC)ship: ambient store at: room temp

    E8409-5MG 5 mg

    E8409-25MG 25 mg

    Erastin 8

    2-[1-[4-[2-(4-Chlorophenoxy)acetyl]-1-piperazinyl]ethyl]-3-(2-ethoxyphenyl)-4(3H)-Quinazolinone[571203786] C30H31ClN4O4 FW 547.04

    N

    O

    NN

    O

    CH3

    NO O

    Cl

    CH3

    Erastin is an antitumor agent selective for tumor cells bearing oncogenic RAS.

    98% (HPLC)ship: ambient store at: room temp

    E7781-1MG 1 mg

    E7781-5MG 5 mg

    10058-F4 8

    S

    NH

    O SH3C

    5-[(4-Ethylphenyl)methylene]-2-thioxo-4-thiazolidinone[403811552] C12H11NOS2 FW 249.35

    10058-F4 is a c-Myc inhibitor.

    98% (HPLC)ship: ambient store at: room temp

    F3680-5MG 5 mg

    F3680-25MG 25 mg

    Fasentin 8

    N-[4-Chloro-3-(trifluoromethyl)phenyl]-3-oxobutan-amide[392721378] C11H9ClF3NO2 FW 279.64

    H3C NH

    OO ClCF3

    Fastentin is a novel of glucose uptake, GluT1 inhibitor.

    98% (HPLC)ship: ambient store at: room temp

    F5557-5MG 5 mg

    F5557-25MG 25 mg

    Gambogic acid 8

    O

    O

    OO

    O

    CH3H3C

    H3C

    CH3

    O

    OHH

    H

    H3C

    H3C

    OH

    H3C

    CH3

    Beta-Guttiferrin; B"-Guttiferrin; Cambogic acid; Guttic acid; Guttatic acid; Beta-Guttilactone; 1,51,5-Methano-1H,3H,11H-furo(3,4-G)pyrano(3,2-B)xanthene-1-crotonic acid[2752650] C38H44O8 FW 628.75

    Gambogic acid acts as a caspase activator and apoptosis inducer.

    >97% (HPLC)ship: ambient store at: room temp

    G8171-5MG 5 mg

    G8171-25MG 25 mg

    Gemcitabine hydrochloride 8

    2-Deoxy-2,2-difluorocytidine; dFdC; dFdC; dFdCyd;LY-188011; Gemzar (Lilly)[122111039] C9H11F2N3O4 HCl FW 299.66

    OH F

    FO

    N

    N

    O

    NH2

    HO HCl

    Gemcitabine is a widely used antineoplastic agent and antimetabolite.

    98% (HPLC)ship: ambient store at: room temp

    G6423-10MG 10 mg

    G6423-50MG 50 mg

    HA 14-1

    2-Amino-6-bromo--cyano-3-(ethoxycarbonyl)-4H-1-benzopyran-4-acetic acidethyl ester; Ethyl [2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)]-4H-chromene-3-carboxylateC17H17BrN2O5 FW 409.23

    HA 14-1 is a nonpeptide apoptosis inducer; Bcl-2 antagonist.

    94% (HPLC)ship: ambient store at: room temp

    H8787-5MG 5 mg

    H8787-25MG 25 mg

    Muristerone A

    MurA; 2,3,5,11,14,20R,22R-Heptahydroxycholest-7-en-6-oneC27H44O8

    Muristerone A is a native phytosteroid known to have insecticidal properties.Induces apoptosis in cell transfected with wild-type Bax and ecdysone-inducible gene expression systems in mammalian cells and transgenicanimals.

    90%ship: ambient store at: room temp

    M7888-1MG 1 mg

    Apoptosis and Cell CycleApoptosis Inducers

    Extract Data: #2393, SMC Pg Count File UNP 1215b

    511

    Cat. No. * NameA5880 B d-AmphetamineA8800 B AlprazolamB159 B ()-1-(4-Bromo-2,5-dimethoxyphenyl)-2-

    ethanamine

    B8263 B BenzphetamineB9275 B BuprenorphineC1277 B ClonazepamC222 B CathineC2517 B ChlordiazepoxideC3196 B S()-CathinoneC5776 B CocaineC8414 B ClobazamC8912 B CocaineD0899 B DiazepamD7412 B ()-2,5-Dimethoxy-4-bromoamphetamineE3638 B EstazolamE8512 B EthylmorphineF103 B FlurazepamF3886 B FentanylF9261 B FlunitrazepamH3635 B -Hydroxybutyric acidH4516 B HydrocodoneH5136 B HydromorphoneL1764 B ()-LorazepamL5143 B LevorphanolL7007 B Lysergic acid diethylamideL7418 B LAAMM0267 B ()-MethadoneM0896 B 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridineM139 B S(+)-3,4-MethylenedioxymethamphetamineM1796 B ()-3,4-Methylenedioxy-N- ethyl amphetamineM200 B ()-N-Methyl-1-(3,4-methylenedioxyphenyl)-2-

    butanamine

    M2017 B Mazindol

    Cat. No. * Name

    M2381 B 5-Methoxy-N,N-dimethyltryptamineM2419 B MidazolamM2892 B MethylphenidateM3142 B MeperidineM3404 B ()-p-MethoxyamphetamineM3528 B Morphine 6--d-glucuronideM5037 B 2-(Methylamino)propiophenoneM6267 B ()-3,4-MethylenedioxyamphetamineM6403 B ()-3,4-MethylenedioxymethamphetamineM6810 B d-threo-MethylphenidateM6935 B l-threo-MethylphenidateM8750 B (+)-MethamphetamineM8777 B MorphineN3785 B NabiloneN3889 B NitrazepamO5254 B OxazepamP127 B (+)-PentazocineP2279 B PsilocinP3029 B PhencyclidineP3654 B PrazepamP3761 B PentobarbitalP5178 B PhenobarbitalT2019 B ThebaineT2386 B 9-TetrahydrocannabinolT9772 B TriazolamUC161 B Morphine-3,6-diglucuronide tetrahydrateUC429 B MidazolamZ103 B Zolpidem68750 B 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridineC5901 B CodeineD7282 B DesmethyldiazepamM3637 B MethaqualoneT4764 B 9-Tetrahydrocannabinol

    *B = BTM-Erlaubnis, E = Endverbleibserklrung

    Licensing Requirements

  • CHM-1 hydrate 8

    2-(2-fluorophenyl)-6,7-methylenedioxy-2-4-quinolonehydrate; NSC 656158C16H10FNO3 xH2O FW 283.25 (Anh)

    NH

    OO

    OF

    xH2O

    CHM-1 possess antimitotic and antiangiogenic antitumor activity.

    99% (HPLC)ship: ambient store at: room temp

    C1244-5MG 5 mg

    C1244-25MG 25 mg

    CIL-102

    1-[4-(Furo[2,3-b]quinolin-4-ylamino)phenyl]ethanone[479077764] C19H14N2O2 FW 302.33

    CIL-102 is a tubulin polymerization inhibitor: apoptosis inducer.

    95% (HPLC)

    US Patent No. 6,750,223. Sold for non-human research purposes under a non-exclusive license agreement with Kaohsiung Medical University.ship: ambient store at: room temp

    C5492-10MG 10 mg

    Clofarabine 8

    (2R,3R,4S,5R)-5-(6-amino-2-chloropurin-9-yl)-4-fluoro-2-(hydroxymethyl)oxolan-3-ol, 2-chloro-2-arabino-fluoro-2-deoxyadenosine[123318821] C10H11ClFN5O3 FW 303.68

    N

    N N

    NNH2

    O

    OH

    F

    HOCl

    Clofarabine is an antimetabolite toxic to nondividing lymphocytes andmonocytes.

    98% (HPLC)ship: ambient store at: room temp

    C7495-5MG 5 mg

    C7495-25MG 25 mg

    Combretastatin A4 8

    H3CO

    H3CO OCH3

    OH

    OCH3

    2-Methoxy-5-[(1Z)-2-(3,4,5-trimethoxyphenyl)ethenyl]phenol; CA4; 1-(3,4,5-Tri-methoxyphenyl)-2-(3-hydroxy-4-methoxyphenyl) ethane 3,4,5-trimethoxy-3-hydroxy-4-methoxystilbene[117048596] C18H20O5 FW 316.35

    Combretastatin A4 is a vascular disrupting agent (VDA) that targets tumorvasculature to inhibit angiogenesis.

    98% (HPLC)ship: ambient store at: room temp

    C7744-5MG 5 mg

    C7744-25MG 25 mg

    CP-31398 dihydrochloride hydrate 8

    N

    N

    HN

    OCH3

    2HCl xH2O

    NCH3

    CH3

    N-[2-[2-(4-Methoxyphenyl)ethenyl]-4-quinazolinyl]-N,N-dimethyl-1,3-propanedi-amine dihydrochloride hydrateC22H26N4O2HCl xH2O FW 435.39 (Anh)

    CP-31398 dihyrochloride hydrate is a p53 stabilizer; apoptosis inducer.

    98% (HPLC)

    Sold for research purposes under agreement from Pfizer Inc.ship: ambient store at: room temp

    PZ0115-5MG 5 mg

    PZ0115-25MG 25 mg

    Darinaparsin 8

    NH2HO

    O

    HN

    ONH

    OOH

    OSAs CH3H3C

    L--Glutamyl-S-(dimethylarsanyl)-L-cysteinylglycine; S-dimethylarsino-glutathione[69819869] C12H22AsN3O6S FW 411.31

    Darinaparsin is a antineoplastic organic arsenic.

    95% (HPLC)ship: ambient store at: room temp

    D2071-5MG 5 mg

    D2071-25MG 25 mg

    DMXAA

    5,6-Dimethylxanthenone-4-acetic Acid; ASA404; Vadimezan[117570533] C17H14O4 FW 282.29

    DMXAA is an apoptosis inducer; anti-vascular.

    98% (HPLC)ship: ambient store at: room temp

    D5817-5MG 5 mg

    D5817-25MG 25 mg

    EF-24 8

    F

    NH

    FO

    HCl

    (3E,5E)-3,5-bis[(2-fluorophenyl)methylene]-4-piperidinone[342808406] C19H15F2NO FW 311.33

    EF-24 is an IKK inhibitor and curcumin analog. EF-24 is more potent andbioavailable than curcumin, with 10-fold greater potency in cell deathinduction.

    Apoptosis and Cell CycleApoptosis Inducers

    Extract Data: #2393, SMC Pg Count File UNP 1215b

    412 Licensing Requirements

    Regulatory Information: FranceOrdering Procedure for Controlled SubstancesFor both stupfiants and psychotropes, please provide a written order as well as the original purchasing authorization document

    Please send your request to the following agencies:

    for Narcotics (stupfiants):AGENCE FRANCAISE DE SECURITE SANITAIRE DES PRODUITS DE SANTE Unit Stupfiants et Psychotropes 143 145 Bd Anatole France 923 85 Saint Denis Cedex Tl : 01 55 87 35 91

    for psychotropic drugs (psychotropes):Your regional Prfecture DRASS services

    Administrative fees: for each controlled substances order placed in France, 61 HT of administrative fees will be added to the invoice, to support the importation and exportation authorization paper-work Sigma-Aldrich needs to obtain from French and/or American administrations

  • 98% (HPLC)ship: ambient store at: room temp

    E8409-5MG 5 mg

    E8409-25MG 25 mg

    Erastin 8

    2-[1-[4-[2-(4-Chlorophenoxy)acetyl]-1-piperazinyl]ethyl]-3-(2-ethoxyphenyl)-4(3H)-Quinazolinone[571203786] C30H31ClN4O4 FW 547.04

    N

    O

    NN

    O

    CH3

    NO O

    Cl

    CH3

    Erastin is an antitumor agent selective for tumor cells bearing oncogenic RAS.

    98% (HPLC)ship: ambient store at: room temp

    E7781-1MG 1 mg

    E7781-5MG 5 mg

    10058-F4 8

    S

    NH

    O SH3C

    5-[(4-Ethylphenyl)methylene]-2-thioxo-4-thiazolidinone[403811552] C12H11NOS2 FW 249.35

    10058-F4 is a c-Myc inhibitor.

    98% (HPLC)ship: ambient store at: room temp

    F3680-5MG 5 mg

    F3680-25MG 25 mg

    Fasentin 8

    N-[4-Chloro-3-(trifluoromethyl)phenyl]-3-oxobutan-amide[392721378] C11H9ClF3NO2 FW 279.64

    H3C NH

    OO ClCF3

    Fastentin is a novel of glucose uptake, GluT1 inhibitor.

    98% (HPLC)ship: ambient store at: room temp

    F5557-5MG 5 mg

    F5557-25MG 25 mg

    Gambogic acid 8

    O

    O

    OO

    O

    CH3H3C

    H3C

    CH3

    O

    OHH

    H

    H3C

    H3C

    OH

    H3C

    CH3

    Beta-Guttiferrin; B"-Guttiferrin; Cambogic acid; Guttic acid; Guttatic acid; Beta-Guttilactone; 1,51,5-Methano-1H,3H,11H-furo(3,4-G)pyrano(3,2-B)xanthene-1-crotonic acid[2752650] C38H44O8 FW 628.75

    Gambogic acid acts as a caspase activator and apoptosis inducer.

    >97% (HPLC)ship: ambient store at: room temp

    G8171-5MG 5 mg

    G8171-25MG 25 mg

    Gemcitabine hydrochloride 8

    2-Deoxy-2,2-difluorocytidine; dFdC; dFdC; dFdCyd;LY-188011; Gemzar (Lilly)[122111039] C9H11F2N3O4 HCl FW 299.66

    OH F

    FO

    N

    N

    O

    NH2

    HO HCl

    Gemcitabine is a widely used antineoplastic agent and antimetabolite.

    98% (HPLC)ship: ambient store at: room temp

    G6423-10MG 10 mg

    G6423-50MG 50 mg

    HA 14-1

    2-Amino-6-bromo--cyano-3-(ethoxycarbonyl)-4H-1-benzopyran-4-acetic acidethyl ester; Ethyl [2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)]-4H-chromene-3-carboxylateC17H17BrN2O5 FW 409.23

    HA 14-1 is a nonpeptide apoptosis inducer; Bcl-2 antagonist.

    94% (HPLC)ship: ambient store at: room temp

    H8787-5MG 5 mg

    H8787-25MG 25 mg

    Muristerone A

    MurA; 2,3,5,11,14,20R,22R-Heptahydroxycholest-7-en-6-oneC27H44O8

    Muristerone A is a native phytosteroid known to have insecticidal properties.Induces apoptosis in cell transfected with wild-type Bax and ecdysone-inducible gene expression systems in mammalian cells and transgenicanimals.

    90%ship: ambient store at: room temp

    M7888-1MG 1 mg

    Apoptosis and Cell CycleApoptosis Inducers

    Extract Data: #2393, SMC Pg Count File UNP 1215b

    513 Licensing Requirements

    Cat. No. rules Name

    A5880 stupfiant d-AmphetamineA8800 psychotrope AlprazolamB159 stupfiant ()-1-(4-Bromo-2,5-dimethoxyphenyl)-2-

    ethanamine

    B8263 stupfiant BenzphetamineB9156 psychotrope ButorphanolB9275 psychotrope BuprenorphineC1277 psychotrope ClonazepamC222 psychotrope CathineC2517 psychotrope ChlordiazepoxideC3196 stupfiant S()-CathinoneC5776 stupfiant CocaineC8414 psychotrope ClobazamC8912 stupfiant CocaineD0899 psychotrope DiazepamD7412 stupfiant ()-2,5-Dimethoxy-4-bromoamphetamineE3638 psychotrope EstazolamE8512 stupfiant EthylmorphineF103 psychotrope FlurazepamF3886 stupfiant FentanylF9261 psychotrope FlunitrazepamH1392 stupfiant HarmalineH3635 stupfiant -Hydroxybutyric acidH4516 stupfiant HydrocodoneH5136 stupfiant HydromorphoneH7909 stupfiant HU-210K113 stupfiant Ketamine hydrochloride/xylazine

    hydrochloride

    K1884 stupfiant S-(+)-KetamineK2753 stupfiant ()-KetamineL1764 psychotrope ()-LorazepamL5143 stupfiant LevorphanolL7007 stupfiant Lysergic acid diethylamideM0267 stupfiant ()-MethadoneM139 stupfiant S(+)-3,4-MethylenedioxymethamphetamineM1796 stupfiant ()-3,4-Methylenedioxy-N- ethyl-

    amphetamine

    M200 stupfiant ()-N-Methyl-1-(3,4-methylenedioxyphenyl)-2-butanamine

    Cat. No. rules Name

    M2017 psychotrope MazindolM2419 psychotrope MidazolamM2892 stupfiant MethylphenidateM3142 stupfiant MeperidineM3404 stupfiant ()-p-MethoxyamphetamineM3528 stupfiant Morphine 6--d-glucuronideM5037 stupfiant 2-(Methylamino)propiophenoneM6267 stupfiant ()-3,4-MethylenedioxyamphetamineM6403 stupfiant ()-3,4-Methylenedioxymeth amphetamine

    M6810 stupfiant d-threo-MethylphenidateM6935 stupfiant l-threo-MethylphenidateM8750 stupfiant (+)-MethamphetamineUC429 psychotrope Midazolam hydrochlorideM8777 stupfiant MorphineN3785 stupfiant NabiloneN3889 psychotrope NitrazepamO5254 psychotrope OxazepamP127 stupfiant (+)-PentazocineP2279 stupfiant PsilocinP3029 stupfiant PhencyclidineP3654 psychotrope PrazepamP3761 psychotrope PentobarbitalP5178 psychotrope PhenobarbitalT2019 stupfiant ThebaineT2386 stupfiant 9-TetrahydrocannabinolT9772 psychotrope TriazolamUC161 stupfiant Morphine-3,6-diglucuronide tetrahydrateZ0502 psychotrope ZaleplonZ103 psychotrope ZolpidemZ4900 psychotrope ZopicloneC5901 stupfiant CodeineD7282 psychotrope DesmethyldiazepamM3637 stupfiant MethaqualoneN2144 psychotrope NorfludiazepamT4764 stupfiant 9-Tetrahydrocannabinol

  • CHM-1 hydrate 8

    2-(2-fluorophenyl)-6,7-methylenedioxy-2-4-quinolonehydrate; NSC 656158C16H10FNO3 xH2O FW 283.25 (Anh)

    NH

    OO

    OF

    xH2O

    CHM-1 possess antimitotic and antiangiogenic antitumor activity.

    99% (HPLC)ship: ambient store at: room temp

    C1244-5MG 5 mg

    C1244-25MG 25 mg

    CIL-102

    1-[4-(Furo[2,3-b]quinolin-4-ylamino)phenyl]ethanone[479077764] C19H14N2O2 FW 302.33

    CIL-102 is a tubulin polymerization inhibitor: apoptosis inducer.

    95% (HPLC)

    US Patent No. 6,750,223. Sold for non-human research purposes under a non-exclusive license agreement with Kaohsiung Medical University.ship: ambient store at: room temp

    C5492-10MG 10 mg

    Clofarabine 8

    (2R,3R,4S,5R)-5-(6-amino-2-chloropurin-9-yl)-4-fluoro-2-(hydroxymethyl)oxolan-3-ol, 2-chloro-2-arabino-fluoro-2-deoxyadenosine[123318821] C10H11ClFN5O3 FW 303.68

    N

    N N

    NNH2

    O

    OH

    F

    HOCl

    Clofarabine is an antimetabolite toxic to nondividing lymphocytes andmonocytes.

    98% (HPLC)ship: ambient store at: room temp

    C7495-5MG 5 mg

    C7495-25MG 25 mg

    Combretastatin A4 8

    H3CO

    H3CO OCH3

    OH

    OCH3

    2-Methoxy-5-[(1Z)-2-(3,4,5-trimethoxyphenyl)ethenyl]phenol; CA4; 1-(3,4,5-Tri-methoxyphenyl)-2-(3-hydroxy-4-methoxyphenyl) ethane 3,4,5-trimethoxy-3-hydroxy-4-methoxystilbene[117048596] C18H20O5 FW 316.35

    Combretastatin A4 is a vascular disrupting agent (VDA) that targets tumorvasculature to inhibit angiogenesis.

    98% (HPLC)ship: ambient store at: room temp

    C7744-5MG 5 mg

    C7744-25MG 25 mg

    CP-31398 dihydrochloride hydrate 8

    N

    N

    HN

    OCH3

    2HCl xH2O

    NCH3

    CH3

    N-[2-[2-(4-Methoxyphenyl)ethenyl]-4-quinazolinyl]-N,N-dimethyl-1,3-propanedi-amine dihydrochloride hydrateC22H26N4O2HCl xH2O FW 435.39 (Anh)

    CP-31398 dihyrochloride hydrate is a p53 stabilizer; apoptosis inducer.

    98% (HPLC)

    Sold for research purposes under agreement from Pfizer Inc.ship: ambient store at: room temp

    PZ0115-5MG 5 mg

    PZ0115-25MG 25 mg

    Darinaparsin 8

    NH2HO

    O

    HN

    ONH

    OOH

    OSAs CH3H3C

    L--Glutamyl-S-(dimethylarsanyl)-L-cysteinylglycine; S-dimethylarsino-glutathione[69819869] C12H22AsN3O6S FW 411.31

    Darinaparsin is a antineoplastic organic arsenic.

    95% (HPLC)ship: ambient store at: room temp

    D2071-5MG 5 mg

    D2071-25MG 25 mg

    DMXAA

    5,6-Dimethylxanthenone-4-acetic Acid; ASA404; Vadimezan[117570533] C17H14O4 FW 282.29

    DMXAA is an apoptosis inducer; anti-vascular.

    98% (HPLC)ship: ambient store at: room temp

    D5817-5MG 5 mg

    D5817-25MG 25 mg

    EF-24 8

    F

    NH

    FO

    HCl

    (3E,5E)-3,5-bis[(2-fluorophenyl)methylene]-4-piperidinone[342808406] C19H15F2NO FW 311.33

    EF-24 is an IKK inhibitor and curcumin analog. EF-24 is more potent andbioavailable than curcumin, with 10-fold greater potency in cell deathinduction.

    Apoptosis and Cell CycleApoptosis Inducers

    Extract Data: #2393, SMC Pg Count File UNP 1215b

    414 Licensing Requirements

    Label Licenses for BiotechnologyZFN License Agreement This Product and its use are the subject of one or more of the following

    patents controlled by Sangamo BioSciences, Inc : U S Patent Nos 6,534,261, 6,607,882, 6,746,838, 6,794,136, 6,824,978, 6,866,997, 6,933,113, 6,979,539, 7,013,219, 7,030,215, 7,220,719, 7,241,573, 7,241,574, 7,585,849, 7,595,376, 6,903,185, 6,479,626, US20030232410, US20090203140 and corresponding foreign patent applications and patents

    For the complete ZFN license agreement, visit http://www.sigmaaldrich.com/life-science/functional-genomics-and-rnai/zinc-finger-nuclease-technology/zfn-license-agreement.html

    PCR License Agreement1) roche enzyme products Conveying polymerase patent rights

    (research field)

    NOTICe TO purChASer: lImITed lICeNSe

    Use of this product is covered by one or more of the following U S patents and corresponding patent claims outside the U S : 5,789,224, 5,618,711, 6,127,155 and claims outside the U S corresponding to expired U S Patent No 5,079,352 The purchase of this product includes a limited, non-transferable immunity from suit under the foregoing patent claims for using only this amount of product for the purchasers own internal research No right under any other patent claim, no right to perform any patented method, and no right to perform commercial services of any kind, including without limitation reporting the results of purchasers activities for a fee or other commercial consideration, is conveyed expressly, by implication, or by estoppel This product is for research use only Diagnostic uses under Roche patents require a separate license from Roche Further information on purchasing licenses may be obtained by contacting the Director of Licensing, Applied Biosystems, 850 Lincoln Centre Drive, Foster City, California 94404, USA

    4) rT and rTpCr products (research field)

    NOTICe TO purChASer: lImITed lICeNSe

    Use of this product is covered by one or more of the following U S patents and corresponding patent claims outside the U S : 5,994,056 and 6,171,785 The purchase of this product includes a limited, non-transferable immunity from suit under the foregoing patent claims for using only this amount of product for the purchasers own internal research No right under any other patent claim (such as apparatus or system claims in U S Patent No 6,814,934) and no right to perform commercial services of any kind, including without limitation reporting the results of purchasers activities for a fee or other commercial consideration, is conveyed expressly, by implication, or by estoppel This product is for research use only Diagnostic uses under Roche patents require a separate license from Roche Further information on purchasing licenses may be obtained by contacting the Director of Licensing, Applied Biosystems, 850 Lincoln Centre Drive, Foster City, California 94404, USA

    5) licensed dsdNABinding dye research kits (research field)

    NOTICe TO purChASer: lImITed lICeNSe

    Use of this product is covered by one or more of the following U S patents and corresponding patent claims outside the U S : 5,994,056 and 6,171,785 The purchase of this product includes a limited, non-transferable immunity from suit under the foregoing patent claims for using only this amount of product for the purchasers own internal research No right under any other patent claim (such as apparatus or system claims in U S Patent No 6,814,934) and no right to perform commercial services of any kind, including without limitation reporting the results of purchasers activities for a fee or other commercial consideration, is conveyed expressly, by implication, or by estoppel This product is for research use only Diagnostic uses under Roche patents require a separate license from Roche Further information on purchasing licenses may be obtained by contacting the Director of Licensing, Applied Biosystems, 850 Lincoln Centre Drive, Foster City, California 94404, USA

    7) Authorized 5 Nuclease Core kit (i.e., without licensed probe) (research field)

    NOTICe TO purChASer: lImITed lICeNSe

    A license to perform the patented 5 Nuclease Process for research is obtained by the purchase of (i) both Authorized 5 Nuclease Core Kit and Licensed Probe, (ii) a Licensed 5 Nuclease Kit, or (iii) license rights from Applied Biosystems This product is an Authorized 5 Nuclease Core Kit Use of this product is covered by one or more of the following claims outside the U S corresponding to expired U S Patent Nos 5,210,015 and 5,487,972 The purchase of this product includes a limited, non-transferable immunity from suit under the foregoing patent claims for using only this amount of product for the purchasers own internal research Separate purchase of a Licensed Probe would convey rights under U S Patents and corresponding patent claims outside the U S : 5,538,848, 5,723,591, 5,876,930, 6,030,787, 6,258,569, 5,804,375 (claims 1-12 only), and claims outside the United States corresponding to U S Patent No 6,214,979 No right under any other patent claim and no right to perform commercial services of any kind, including without limitation reporting the results of purchasers activities for a fee or other commercial consideration, is conveyed expressly, by implication, or by estoppel This product is for research use only Diagnostic uses under Roche patents require a separate license from Roche Further information on purchasing licenses may be obtained from the Director of Licensing, Applied Biosystems, 850 Lincoln Centre Drive, Foster City, California 94404, USA

    13) for products Subject to Section 2.17(d) That Could Be Confused with licensed royaltyBearing products and That do Not Convey Necessary patent rights for the 5 Nuclease process and/or dsdNABinding dye process

    NOTICe TO purChASer: dISClAImer Of lICeNSe

    No license is conveyed with the purchase of this product under any of U S Patents Nos , 5,804,375, 5,994,056, 6,171,785, 5,538,848, 5,723,591, 5,876,930, 6,030,787, and 6,258,569, and corresponding patents outside the United States, or any other patents or patent applications, relating to the 5 Nuclease and dsDNA-Binding Dye Processes For further information contact the Director of Licensing, Applied Biosystems, 850 Lincoln Centre Drive, Foster City, California 94404, USA

  • bioeditingbioediting

    Biokinetic.Knockout your gene of interest with the power of CompoZr Zinc Finger Nuclease technology.

    Generate knockouts faster than ever with the precision of CompoZr Zinc Finger Nuclease technology from Sigma Life Science. Choose from a selection of pre-validated CompoZr Knockout ZFNs and help push your applications closer to breakthroughs and beyond.

    Target your gene for exceptional results.

    wherebiobegins.com/bioediting

    CompoZr, Sigma and Sigma-Aldrich are registered trademarks of Sigma-Aldrich Co. and its affiliate Sigma-Aldrich Biotechnology, LP.

  • LOPAC LibrariesLOPAC1280

    Library of Pharmacologically Active Compounds

    Includes the latest, drug-like molecules in the fields of Cell Signaling &Neuroscience:

    Apoptosis G Proteins & Cyclic Nucleotides Gene Regulation & Expression Ion Channels Lipid Signaling Multi-Drug Resistance Neurotransmission Phosphorylation

    SDFile provided to construct a database containing:

    Structure Primary Name Secondary Name Pharmacological Activity Product Number Rack Position

    For sale in the U.S. only. Customers outside of the U.S