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Bimonthly Meeting on Jan. 23, 2009 Chemical Information on Phantom by Gaussian Function Amarjeet Bhullar

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15*15=225 Voxels

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7*7=49 Voxels

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7*7=49 Voxels and 15*15=225 Voxels

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Voxel Size Comparison

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Metabolite peaks fit by Gaussian function

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Cho=26.4059 Cre=38.3233 NAA=50.3961 Calculation of Metabolite Concentrations

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Cho=30.047 Cre=45.8772 NAA=51.899 Calculation of Metabolite Concentrations

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Cho=27.7975 Cre=39.7157 NAA=50.4718 Calculation of Metabolite Concentrations

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Cho=34.0246 Cre=49.0628 NAA=60.5868 Calculation of Metabolite Concentrations

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Cho=123.506 Cre=174.144 NAA=220.372 Calculation of Metabolite Concentrations

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Cho=67.1154 Cre=74.2094 NAA=93.7448 Calculation of Metabolite Concentrations

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15*15ChoCreNAA Vox#3326.405938.323350.3961 Vox#3430.047045.877251.8990 Vox#4827.797539.715750.4718 Vox#4934.024649.062860.5869 Total Con.110.6558172.979213.3538 15*15ChoCreNAA Vox#33+34+ 48+49 123.506174.144220.372 7*7ChoCreNAA Vox#967.115474.209493.7448 Voxel Comparison

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Conclusion: Even difference of smallest fraction between voxel size (7*7 and 15*15) creates different metabolite concentrations. Suggestions are welcome

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Row Wise Distribution of Cho/Cre

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Row Wise Distribution of Cho/NAA

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Voxel #1Gaussian Cho/Cre 0.751014 Cho/NAA0.82592 Voxel #2Gaussian Cho/Cre0.920288 Cho/NAA1.204818 Voxel #3Gaussian Cho/Cre1.026504 Cho/NAA1.00366 Metabolite Ratios by Gaussian function Voxel #4Gaussian Cho/Cre0.934274 Cho/NAA1.265779

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Voxel #4Gaussian Cho/Cre0.934274 Cho/NAA1.265779 Voxel #5Gaussian Cho/Cre0.913693 Cho/NAA0.950665 Voxel #6Gaussian Cho/Cre0.905497 Cho/NAA1.00024 Voxel #7Gaussian Cho/Cre0.890625 Cho/NAA1.284948 Metabolite Ratios by Gaussian function

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Voxel #8Gaussian Cho/Cre0.860931 Cho/NAA0.544306 Voxel #9Gaussian Cho/Cre0.904406 Cho/NAA0.715937 Voxel #10Gaussian Cho/Cre0.817914 Cho/NAA0.667594 Voxel #11Gaussian Cho/Cre0.836532 Cho/NAA0.680032 Metabolite Ratios by Gaussian function

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Voxel #12Gaussian Cho/Cre0.859035 Cho/NAA0.683185 Voxel #13Gaussian Cho/Cre0.84962 Cho/NAA0.697155 Voxel #14Gaussian Cho/Cre0.770389 Cho/NAA0.74367 Voxel #15Gaussian Cho/Cre0.915505 Cho/NAA0.559509 Metabolite Ratios by Gaussian function

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Voxel #16Gaussian Cho/Cre0.89351 Cho/NAA0.650015 Voxel #17Gaussian Cho/Cre 0.807657 Cho/NAA 0.605227 Voxel #18Gaussian Cho/Cre0.807195 Cho/NAA0.619962 Voxel #19Gaussian Cho/Cre0.839769 Cho/NAA0.611889 Metabolite Ratios by Gaussian function

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Voxel #20Gaussian Cho/Cre0.815158 Cho/NAA0.617085 Voxel #21Gaussian Cho/Cre0.691482 Cho/NAA0.592537 Voxel #22Gaussian Cho/Cre0.808174 Cho/NAA0.48208 Voxel #23Gaussian Cho/Cre0.842664 Cho/NAA0.615965 Metabolite Ratios by Gaussian function

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Voxel #24Gaussian Cho/Cre0.80954 Cho/NAA0.616462 Voxel #25Gaussian Cho/Cre0.824471 Cho/NAA0.620819 Voxel #26Gaussian Cho/Cre0.812873 Cho/NAA0.593714 Voxel #27Gaussian Cho/Cre0.764973 Cho/NAA0.614783 Metabolite Ratios by Gaussian function

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Voxel #28Gaussian Cho/Cre0.693088 Cho/NAA0-643046 Voxel #29Gaussian Cho/Cre0.820805 Cho/NAA0.541781 Voxel #30Gaussian Cho/Cre0.863645 Cho/NAA0.615628 Voxel #31Gaussian Cho/Cre0.822132 Cho/NAA0.615398 Metabolite Ratios by Gaussian function

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Voxel #32Gaussian Cho/Cre0.863442 Cho/NAA0.64706 Voxel #33Gaussian Cho/Cre0.829424 Cho/NAA0.630388 Voxel #34Gaussian Cho/Cre 0.826255 Cho/NAA 0.64566 Voxel #35Gaussian Cho/Cre0.838811 Cho/NAA0.755696 Metabolite Ratios by Gaussian function

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Voxel #36Gaussian Cho/Cre0.813257 Cho/NAA0.524243 Voxel #37Gaussian Cho/Cre0.883596 Cho/NAA0.565531 Voxel #38Gaussian Cho/Cre0.895173 Cho/NAA0.661893 Voxel #39Gaussian Cho/Cre0.915392 Cho/NAA0.724875 Metabolite Ratios by Gaussian function

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Voxel #40Gaussian Cho/Cre0.933848 Cho/NAA0.707293 Voxel #41Gaussian Cho/Cre 0.877934 Cho/NAA 0.739058 Voxel #42Gaussian Cho/Cre0.89324 Cho/NAA0.83322 Voxel #43Gaussian Cho/Cre0.620034 Cho/NAA0.399859 Metabolite Ratios by Gaussian function

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Voxel #44Gaussian Cho/Cre0.77063 Cho/NAA0.522992 Voxel #45Gaussian Cho/Cre0.77063 Cho/NAA0.529867 Voxel #46Gaussian Cho/Cre0.92655 Cho/NAA0.663082 Voxel #47Gaussian Cho/Cre 0.903481 Cho/NAA 0.627585 Metabolite Ratios by Gaussian function

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Voxel #48Gaussian Cho/Cre0.879797 Cho/NAA0.644314 Voxel #49Gaussian Cho/Cre0.659546 Cho/NAA0.601717 Metabolite Ratios by Gaussian function

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Conclusion: All the data reveals that the Gaussian Function is the best fit for Magnetic Resonance Spectroscopy. Suggestions are welcome