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PRINCIPLE

OF BICARBONATE UREA METHOD

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• A method based on the principe o!isotopic di"tion o! in!"sed abeedbicarbonate# and the ass"mptionthat the speci$c acti%it& o! "rinar&"rea ' ER (ibne& et a# )**+,

• An indicator o! CO) prod"ction -ithin

the bod&

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•  The e.tent o! isotopic di"tiondepends on the rate o! entr& o!abeed CO)# in!"sed as bicarbonate#

reati%e to the rate o! endo/eno"sCO) prod"ction

• 0hen CO) prod"ction is hi/h# the

enrichment or speci$c acti%it& o! CO)in "rinar& "rea is o-# and %ise %ersa