The BioProfile Nutrigenomics is supported by

BioProfile NutrigenomicsArthur-Scheunert-Allee 114-116 | D-14558 NuthetalPhone +49 33200 88 385 | Fax +49 33200 88 398mail@nutrigenomik.de | www.nutrigenomik.de

NutrigenomicsNutrigenomics is a highly innovative and fast-growing interdisci-plinary field of research linking genome research, plant biotech-nology and molecular nutritional research and offering newapplications for medicine and nutrition. Nutrigenomics aims atproviding an understanding for how nutrition affects the balancebetween health and disease. Food ingredients interact with thehuman genome on a molecular and systemic level. To what extentdiet influences the balanced status may depend on an individuals’genetic makeup. Individual variants of genes need to be identifiedand characterized and the modifying effect of gene expressionand structure by food ingredients has yet to be elucidated. Thiswill open up new perspectives for the prevention, reliable earlydiagnosis and tailor-made therapies for nutrition-related diseases,promoting advanced technologies and services.

BioProfileNUTRIGENOMICS

Berlin-Brandenburg RegionThe Berlin-Brandenburg region is an outstanding location ofhuman and plant genome research. In addition, excellent expertisein the field of molecular and clinical nutritional research is available.Besides the well-known research institutes German Institute ofHuman Nutrition (Potsdam-Rehbrücke), Max Planck Institutes forMolecular Genetics (Berlin-Dahlem) and Molecular Plant Physiology(Potsdam-Golm) there are a lot of biotech and life-sciencecompanies. Since 1999 the regional Nutrigenomics network hasbeen established, supported by the non-profit association "Vereinzur Förderung der Nutrigenomforschung" and the regionalbiotechnology agency BioTOP Berlin-Brandenburg. Networkpartners include local universities and research institutes, privateenterprises, public-sector organizations and various collaborativeproject groups. In addition to activities in connection with thegovernment-sponsored BioProfile program, several long-terminfrastructural initiatives have been launched, such as involvementby the German Institute of Human Nutrition in the EU-fundedNetwork of Excellence on Nutrition and Genomics and the creationof the Center for Functional Genomics.

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BioProfileBioProfile is a development program of the German federalministry of education and research (BMBF) to expand theindustrial application of academic knowledge in the lifesciences. To shape their specific profile, financial support isgiven to German regions on a competitive basis. With aconcept termed “Genomics and Plant Biotechnology at theService of Diagnosis, Prevention and Therapy of Nutrition-Related Diseases“ the Berlin-Brandenburg region wassuccessful in this competition and will receive up to EUR 18million of funding for application-related projects in the fieldof nutrigenomics until 2006. Since the time of grant approval,the protagonists have been busy implementing their concept,with the aim of developing powerful resources, venturing intonew areas of application, building up skills and expertise andcreating a strong regional profile. Since 2003, the awardedfunds have helped to finance numerous innovative projects,ranging from basic research to the development of novelproducts and services and the formation of spin-off companies.Research and development activities focus on metabolicsyndrome, obesity, cardio-vascular diseases, diabetes, cancer,and allergies.

PROJECTS & PARTNERS

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Metabolomic analysis to diagnose nutritional diseasesmetanomics GmbHMax Planck Institute of Molecular Plant PhysiologyGerman Institute of Human Nutrition

Adipositas-ChipMicroarray-based identification and analysis of genetic factors in obesity for thedevelopment of therapeutics

Scienion AGFraunhofer Institute for Biomedical Engineering IBMTCharité – University Medicine Berlin

Metabolic and genetic profiles – MGPGerman Institute of Human NutritionTechnical University of Berlin, Food TechnologyFraunhofer Institute for Biomedical Engineering IBMT

Innovations in treatment concepts for the metabolic syndrome –with focus on hypertension

Charité – University Medicine BerlinGerman Institute of Human NutritionMax Planck Institute for Molecular Genetics

Genetics and pharmacogenomics of obesityMax Planck Institute for Molecular GeneticsMax Delbrück Center for Molecular MedicineCharité – University Medicine BerlinAGOWA

Novel Spiegelmer-based therapeutic approach to obesityNOXXON Pharma AG

Novel targets in diagnosis and treatment of obesityDeveloGen AGGerman Institute of Human Nutrition

PhysioSim - an in silico disease model for the diagnosis ofobesity-induced type-2-diabetes

MicroDiscovery GmbHGerman Institute of Human NutritionMax Planck Institute for Molecular Genetics

Development of the real-time nanowell PCR technology forhigh-throughput analysis of gene expression profiles applied tocardiovascular diseases

Max Planck Institute for Molecular Genetics

AllerGenChipAn integrated DNA-chip-based assay system for the clinically validatedthreshold detection of allergenic food components

Congen Biotechnologie GmbHFraunhofer Institute for Biomedical Engineering IBMTCharité – University Medicine Berlin

Allergen profiling in crop plants and plant-derived food usingnovel proteomic technologies

Proteome Factory AGMax Planck Institute of Molecular Plant PhysiologyCharité – University Medicine Berlin

DNA adducts for the assessment of safety of conventional andnovel foods

German Institute of Human NutritionMax Planck Institute of Molecular Plant Physiology

Humanized mouse models for xenobiotic-metabolising enzymesGerman Institute of Human NutritionMax Planck Institute for Molecular Genetics

Identification of novel diagnostic markers for coeliac diseaseand investigation of immuno-reactive compounds in nutritionalsources

in.vent Diagnostica GmbHCharité – University Medicine BerlinMax Planck Institute for Molecular Genetics

Identification of natural products for prevention of the metabolicsyndrome and cancer

AnalytiCon Discovery AGGerman Institute of Human NutritionMax Planck Institute for Molecular GeneticsUniversity of Potsdam

Development of food additives with tumour-prophylactic potentialfor gastrointestinal tumours based on micro organisms of thegut flora

Glycotope GmbHGerman Institute of Human Nutrition

Colon Cancer GenomicsDevelopment of a non-invasive assay for the early detection of preneoplasticand neoplastic lesions in the human colon

Biotecon Diagnostics GmbHUniversity of Potsdam

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