BDA LIBRARY MEDLINE SEARCH USE OF ALOE VERA IN … · 2015-06-12 · BDA LIBRARY MEDLINE SEARCH USE...

BDA LIBRARY MEDLINE SEARCH

USE OF ALOE VERA IN DENTISTRY

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Database: Ovid MEDLINE(R) In-Process & Other Non-Indexed Citations and Ovid MEDLINE(R) <1946 to Present> Search Strategy: -------------------------------------------------------------------------------- 1 (aloe adj vera).tw. (813) 2 limit 1 to dentistry journals (39) 3 exp Tooth Diseases/ (145760) 4 exp Periodontal Diseases/ (72291) 5 exp Oral Surgical Procedures/ (53018) 6 1 and (3 or 4 or 5) (10) 7 (tooth or teeth or gingiv$ or periodont$ or dental$ or dentist$ or dentition).ti. (222634) 8 1 and 7 (27) 9 2 or 6 or 8 (53) 10 limit 9 to english language (52) *************************** <1> Unique Identifier 26015726 Status PubMed-not-MEDLINE Authors Mangaiyarkarasi SP; Manigandan T; Elumalai M; Cholan PK; Kaur RP. Authors Full Name Mangaiyarkarasi, S P; Manigandan, T; Elumalai, M; Cholan, Priyanka K; Kaur, Roopam Pal. Institution Mangaiyarkarasi,S P. Department of Pedodontics and Preventive Dentistry, SRM Dental College and Hospital, Ramapuram, Chennai, Tamil Nadu, India. Manigandan,T. Department of Oral Medicine and Radiology, Sree Balaji Dental College and Hospital, Pallikaranai, Chennai, Tamil Nadu, India. Elumalai,M. Department of Pharmacology, Sree Balaji Dental College and Hospital, Pallikaranai, Chennai, Tamil Nadu, India. Cholan,Priyanka K. Department of Pedodontics and Preventive Dentistry, SRM Dental College and Hospital, Ramapuram, Chennai, Tamil Nadu, India. Kaur,Roopam Pal. Department of Pharmacology, Sree Balaji Dental College and Hospital, Pallikaranai, Chennai, Tamil Nadu, India. Title Benefits of Aloe vera in dentistry. [Review] Source Journal of pharmacy and bioallied sciences.. 7(Suppl 1):S255-9, 2015 Apr. Other ID Source: NLM. PMC4439686 Abstract

Aloe vera (Aloe barbadensis) is a plant that belongs to Liliaceae family. The name Aloe derives from the Arabic word "Alloeh" meaning shining bitter substance while "vera" in Latin means true. It contains various minerals and vitamins. It has got various properties such as immunomodulatory, antiviral and antiinflammatory in nature. A. vera can play a significant role in dentistry in treatment of lichen planus, oral submucous fibrosis, recurrent aphthous stomatitis, alveolar osteitis, periodontitis, etc. Publication Type Journal Article. Review. Date Created 20150527 Year of Publication 2015 <2> Unique Identifier 25821369 Status PubMed-not-MEDLINE Authors Prabhakar AR; Karuna YM; Yavagal C; Deepak BM. Authors Full Name Prabhakar, A R; Karuna, Y M; Yavagal, C; Deepak, B M. Institution Prabhakar,A R. Department of Pedodontics and Preventive Dentistry, Bapuji Dental College and Hospital, Davangere, Karnataka, India. Karuna,Y M. Department of Pedodontics and Preventive Dentistry, Bapuji Dental College and Hospital, Davangere, Karnataka, India. Yavagal,C. Department of Pedodontics and Preventive Dentistry, Bapuji Dental College and Hospital, Davangere, Karnataka, India. Deepak,B M. Department of Pedodontics and Preventive Dentistry, Bapuji Dental College and Hospital, Davangere, Karnataka, India. Title Cavity disinfection in minimally invasive dentistry - comparative evaluation of Aloe vera and propolis: A randomized clinical trial. Source Contemporary Clinical Dentistry. 6(Suppl 1):S24-31, 2015 Mar. Other ID Source: NLM. PMC4374313 Abstract CONTEXT: The survival of atraumatic restorative treatment (ART) restorations would probably increase if near total elimination of cariogenic microorganisms could be done in the process of cavity cleaning before going ahead with the restoration. Thus, use of naturally occurring disinfecting agents for achieving this goal could herald a new beginning in the field of contemporary minimum intervention dentistry.




AIMS: To evaluate the efficacy of hand instruments in excavating dental caries and comparatively evaluate the roles of Aloe vera and propolis as potential cavity disinfecting agents after minimally invasive hand excavation of dental caries. SETTINGS AND DESIGNS: Experimental, in vivo intergroup split mouth, randomized clinical trial. SUBJECTS AND METHODS: The study included Group I (Control), Group II (A. vera) and Group III (propolis). Ten patients with three teeth each have occlusal/occlusoproximal lesions suitable for ART were selected. Dentinal samples were collected three times from each tooth viz., preexcavation, postexcavation and postdisinfection of the cavities. These dentinal samples were subjected to microbiological analyses for total viable count. STATISTICAL ANALYSIS USED: Repeated measures of analysis of variance (ANOVA) with Bonferroni post-hoc test and one-way ANOVA with Tukey post-hoc test. RESULTS: In all the three groups, significant amount of bacteria were left behind after hand excavation. Group II and Group III, in which cavities were treated with A. vera and propolis extracts respectively, showed a significant reduction in the bacterial counts when compared to control the group. CONCLUSIONS: Hand excavation alone does not completely eliminate bacteria, which may predispose treated teeth to secondary caries. Both propolis and A. vera extracts can be used as potential natural disinfecting agents, thereby embracing the concept of phytotherapy in minimum intervention dentistry. Publication Type Journal Article. Date Created 20150330 Year of Publication 2015 <3> Unique Identifier 24603910 Status PubMed-not-MEDLINE Authors Karim B; Bhaskar DJ; Agali C; Gupta D; Gupta RK; Jain A; Kanwar A. Authors Full Name Karim, Bushra; Bhaskar, Dara John; Agali, Chandan; Gupta, Devanand; Gupta, Rajendra Kumar; Jain, Ankita; Kanwar, Alpana. Institution Karim,Bushra. Post graduate student, Department of Public Health Dentistry, Teerthankar Mahaveer Dental College and Research Centre, Moradabad, Uttar Pradesh, India; Tel: +91-9808683192; e-mail: [email protected].

Title Effect of Aloe vera mouthwash on periodontal health: triple blind randomized control trial. Source Oral Helath & Dental Management. 13(1):14-9, 2014 Mar. Abstract BACKGROUND: With the increasing incidence of periodontal diseases and development of antibiotic resistance, the global need for alternative treatment modalities, safe, effective, and economical products is the need of time. Aloe vera is a medicinal plant which has the greater medicinal value and enormous properties for curing and preventing oral diseases disease. AIM: The aim of the study was to access the effect of Aloe vera mouthwash on the dental plaque and gingivitis and comparing it with the bench mark control chlorhexidine and placebo. MATERIAL AND METHODS: 345 healthy subjects were randomly allocated in 3 groups to the test group (n=115) - mouthwash containing Aloe vera, Control group (n=115) -chlorhexidene group, Distilled water - Placebo (n=115) . Plaque Index (PI) and Gingival Index (GI) were assessed at days 0, 15 and 30. Subjects were asked to rinse their mouth with the stated mouthwash, twice a day, during a 30-day period. RESULTS: Our result showed that Aloe vera mouthrinse is equally effective in reducing periodontal indices as Chlorhexidine. The results demonstrated a significant reduction of gingival bleeding and plaque indices in both groups over a period of 15 and 30 days as compared to placebo group. There was a significant reduction on plaque and gingivitis in Aloe vera and chlorhexidine groups and no statistically significant difference was observed among them (p>0.05). Aloe vera mouthwash showed no side effects as seen with chlorhexidine. CONCLUSION: The results of the present study indicate that Aloe vera may prove to be an effective mouthwash owing to its ability in reducing periodontal indices. Publication Type Journal Article. Date Created 20140307 Year of Publication 2014 <4> Unique Identifier 25478478 Status PubMed-not-MEDLINE Authors Sujatha G; Kumar GS; Muruganandan J; Prasad TS. Authors Full Name Sujatha, G; Kumar, G Senthil; Muruganandan, J; Prasad, T Srinivasa.




Institution Sujatha,G. Reader, Department of Oral & Maxillofacial Pathology, Sri Venkateswara Dental College & Hospital , Thalambur, Chennai, India . Kumar,G Senthil. Professor, Department of Conservative Dentistry, Sri Venkateswara Dental College & Hospital , Thalambur, Chennai, India . Muruganandan,J. Reader, Department of Oral & Maxillofacial Pathology, Sri Venkateswara Dental College & Hospital , Thalambur, Chennai, India . Prasad,T Srinivasa. Professor & H.O.D, Department of Oral & Maxillofacial Surgery, Dental College & Hospital , Thalambur, Chennai, India . Title Aloe vera in dentistry. Source Journal of Clinical and Diagnostic Research JCDR. 8(10):ZI01-2, 2014 Oct. Other ID Source: NLM. PMC4253296 Abstract Aloe vera is a medicinal plant which has been used for thousands of years. The health benefits of aloe vera is well known and the dental uses of this plant is multiple. Interest is gathering among researchers regarding the use of this plant. Studies have proved the antiseptic, anti inflammatory, antiviral and antifungal properties of aloe vera and the use of this plant is proved beneficial. This plant is proved to be non allergic and very good in building up the immune system. Aloe vera is gaining popularity in dentistry as it is completely natural and there is no side effects being reported with its use. This paper gives an overview of the uses of this miracle plant and its uses in dentistry. Publication Type Journal Article. Date Created 20141205 Year of Publication 2014 <5> Unique Identifier 25252256 Status In-Process Authors Batista VE; Olian DD; Mori GG. Authors Full Name Batista, Victor Eduardo de Souza; Olian, Douglas Daquila; Mori, Graziela Garrido. Institution Batista,Victor Eduardo de Souza. Department of Dental Materials and Prosthodontics, Aracatuba School of Dentistry, UNESP - Univ Estadual Paulista, Aracatuba, SP, Brazil. Olian,Douglas Daquila. Private Practice, Sao Paulo, SP, Brazil. Mori,Graziela Garrido. Department of Integrated Clinics, Adamantina School of Dentistry, FAI - Integrated Colleges of Adamantina, Adamantina, SP, Brazil.

Title Diffusion of hydroxyl ions from calcium hydroxide and Aloe vera pastes. Source Brazilian Dental Journal. 25(3):212-6, 2014. Local Messages *SOME ISSUES AVAILABLE IN BDA LIBRARY - PLEASE ASK, GO TO https://www.bda.org/library/journals-articles/Documents/photocopy-request-form.pdf TO REQUEST THIS ARTICLE FROM THE LIBRARY Abstract This study evaluated the diffusion through the dentinal tubules of hydroxyl ions from different calcium hydroxide (CH) pastes containing Aloe vera. Sixty single-rooted bovine teeth were used. The tooth crowns were removed, the root canals were instrumented and the specimens were assigned to 4 groups (n=15) according to the intracanal medication: Group CH/S - CH powder and saline paste; Group CH/P - CH powder and propylene glycol paste; Group CH/A - calcium hydroxide powder and Aloe vera gel paste; Group CH/A/P - CH powder, Aloe vera powder and propylene glycol paste. After placement of the root canal dressings, the teeth were sealed coronally and apically with a two-step epoxy adhesive. The teeth were placed in identified flasks containing deionized water and stored in an oven with 100% humidity at 37 degreeC. After 3 h, 24 h, 72 h, 7 days, 15 days and 30 days, the deionized water in the flasks was collected and its pH was measured by a pH meter. The obtained data were subjected to statistical analysis at a significance level of 5%. The results demonstrated that all pastes provided diffusion of hydroxyl ions through the dentinal tubules. The combination of Aloe vera and CH (group CH/A) provided a constant release of calcium ions. Group CH/A/P showed the highest pH at 24 and 72 h. In conclusion, the experimental pastes containing Aloe vera were able to enable the diffusion of hydroxyl ions through the dentinal tubules. Publication Type Journal Article. Research Support, Non-U.S. Gov't. Date Created 20140925 Year of Publication 2014 <6> Unique Identifier 25231144 Status In-Process Authors Nejaim Y; I V Silva A; V Vasconcelos T; J N L Silva E; M de Almeida S. Authors Full Name Nejaim, Yuri; I V Silva, Amaro; V Vasconcelos, Taruska; J N L Silva, Emmanuel; M de Almeida, Solange. Institution Nejaim,Yuri. Department of Oral Diagnosis, Piracicaba Dental School, State University of Campinas.




Title Evaluation of radioprotective effect of aloe vera and zinc/copper compounds against salivary dysfunction in irradiated rats. Source Journal of Oral Science. 56(3):191-4, 2014 Sep. Local Messages HELD AT BDA INFORMATION CENTRE FROM 2000 ONWARDS Abstract The aim of this study was to evaluate the radioprotective and reparative effects of compounds based on aloe vera, zinc, and copper against salivary gland dysfunction in Wistar rats. A total of 150 Wistar rats were randomly divided into 12 groups, in which the animals received aloe vera and/or zinc and copper. In eight of these groups the animals were also subjected to irradiation before or after administration of the substances. After 27 days, sialometry tests were performed. Data were analyzed using ANOVA and the Tukey test (P < 0.05). Rats that had been administered aloe vera before or after irradiation showed a significantly higher salivary flow rate than rats that had been simply irradiated. When both substances were administered, a statistically significant difference in the salivary flow rate was observed in comparison with the irradiation alone group seven days after irradiation. The present results suggest that aloe vera exerts positive protective and reparative effects, and can be considered a potential radioprotective substance. Publication Type Journal Article. Date Created 20140918 Year of Publication 2014 <7> Unique Identifier 25046828 Status In-Process Authors Vieira DR; Amaral FM; Maciel MC; Nascimento FR; Liberio SA; Rodrigues VP. Authors Full Name Vieira, Denise R P; Amaral, Flavia MaM; Maciel, Marcia C G; Nascimento, Flavia R F; Liberio, Silvana A; Rodrigues, Vandilson P. Institution Vieira,Denise R P. Federal University of Maranhao, Bacanga Campus, Portugueses Avenue, s/n, Odontology Building, 65085-580 Sao Luis, Maranhao, Brazil. Electronic address: [email protected]. Amaral,Flavia MaM. Federal University of Maranhao, Bacanga Campus, Portugueses Avenue, s/n, Pharmacy Building, 65085-580 Sao Luis, Maranhao, Brazil. Maciel,Marcia C G. Federal University of Maranhao, Bacanga Campus, Portugueses Avenue, s/n, Immune Physiology Laboratory, 65085-580 Sao Luis, Maranhao, Brazil.

Nascimento,Flavia R F. Federal University of Maranhao, Bacanga Campus, Portugueses Avenue, s/n, Immune Physiology Laboratory, 65085-580 Sao Luis, Maranhao, Brazil. Liberio,Silvana A. Federal University of Maranhao, Bacanga Campus, Portugueses Avenue, s/n, Odontology Building, 65085-580 Sao Luis, Maranhao, Brazil. Rodrigues,Vandilson P. Federal University of Maranhao, Bacanga Campus, Portugueses Avenue, s/n, Odontology Building, 65085-580 Sao Luis, Maranhao, Brazil. Title Plant species used in dental diseases: ethnopharmacology aspects and antimicrobial activity evaluation. Source Journal of Ethnopharmacology. 155(3):1441-9, 2014 Sep 29. Abstract ETHNOPHARMACOLOGICAL RELEVANCE: Ethnopharmacological surveys show that several plant species are used empirically by the population, in oral diseases. However, it is necessary to check the properties of these plant species. AIM OF THE STUDY: To evaluate in vitro antimicrobial activity against Streptococcus mutans from plant species selected in a previous ethnopharmacology study. MATERIALS AND METHODS: An ethnopharmacological survey was conducted with users of a dental clinic school services, located in Sao Luis, Maranhao, Brazil, aiming to identify plant species used in oral diseases treatment. From the ethnopharmacological survey, species were selected for in vitro antimicrobial activity evaluation against Streptococcus mutans, by agar diffusion method and determination of Minimum Inhibitory Concentration (MIC). RESULTS: Two hundred and seventy one people participated in the research: 55.7% reported the use of plants for medicinal purposes, 29.5% of which have knowledge and/or use plants for some type of oral disease. Thirty four species belonging to 24 (twenty four) botanical families were reported, being Aloe vera L., Anacardium occidentale L., Schinus terebinthifolius Raddi, Chenopodium ambrosioides L. and Punica granatum L. the most cited. The most commonly reported indications were healing after tooth extraction, followed by toothache, inflammation and bleeding gums., The determination of Minimum Inhibitory Concentration (MIC) demonstrated that Punica granatum L., Psidium guajava L. and Schinus terebinthifolius Raddi showed similar activity to 0.12% chlorhexidine, used as positive control. CONCLUSION: That result is important to follow up the study of these species in the search for new anticariogenic agents originated by plants.Copyright © 2014 Elsevier Ireland Ltd. All rights reserved. Publication Type Journal Article. Date Created 20140916 Year of Publication 2014




<8> Unique Identifier 23315202 Status In-Process Authors Boonyagul S; Banlunara W; Sangvanich P; Thunyakitpisal P. Authors Full Name Boonyagul, Sani; Banlunara, Wijit; Sangvanich, Polkit; Thunyakitpisal, Pasutha. Institution Boonyagul,Sani. Dental Biomaterials Science Program, Graduate School, Faculty of Dentistry, Chulalongkorn University, Bangkok, Thailand. Title Effect of acemannan, an extracted polysaccharide from Aloe vera, on BMSCs proliferation, differentiation, extracellular matrix synthesis, mineralization, and bone formation in a tooth extraction model. Source Odontology/The Society of the Nippon Dental University. 102(2):310-7, 2014 Jul. Abstract Aloe vera is a traditional wound healing medicine. We hypothesized acemannan, a polysaccharide extracted from Aloe vera gel, could affect bone formation. Primary rat bone marrow stromal cells (BMSCs) were treated with various concentrations of acemannan. New DNA synthesis, VEGF, BMP-2, alkaline phosphatase activity, bone sialoprotein, osteopontin expression, and mineralization were determined by [(3)H] thymidine incorporation assay, ELISA, biochemical assay, western blotting, and Alizarin Red staining, respectively. In an animal study, mandibular right incisors of male Sprague-Dawley rats were extracted and an acemannan treated sponge was placed in the socket. After 1, 2, and 4 weeks, the mandibles were dissected. Bone formation was evaluated by dual-energy X-ray absorptiometry and histopathological examination. The in vitro results revealed acemannan significantly increased BMSC proliferation, VEGF, BMP-2, alkaline phosphatase activity, bone sialoprotein and osteopontin expression, and mineralization. In-vivo results showed acemannan-treated groups had higher bone mineral density and faster bone healing compared with untreated controls. A substantial ingrowth of bone trabeculae was observed in acemannan-treated groups. These data suggest acemannan could function as a bioactive molecule inducing bone formation by stimulating BMSCs proliferation, differentiation into osteoblasts, and extracellular matrix synthesis. Acemannan could be a candidate natural biomaterial for bone regeneration. Publication Type Journal Article. Research Support, Non-U.S. Gov't. Date Created 20140814 Year of Publication 2014 <9> Unique Identifier

23607360 Status In-Process Authors Dhingra K. Authors Full Name Dhingra, K. Institution Dhingra,K. Department of Periodontology and Implantology, Bangalore Institute of Dental Sciences and Postgraduate Research Centre, Bangalore, Karnataka, India. Title Aloe vera herbal dentifrices for plaque and gingivitis control: a systematic review. Source Oral Diseases. 20(3):254-67, 2014 Apr. Local Messages THIS JOURNAL IS AVAILABLE IN THE BDA LIBRARY Abstract OBJECTIVES: To evaluate the effectiveness of aloe vera containing herbal dentifrices in improving plaque control and gingival health. METHODS: A manual and electronic literature (MEDLINE and Cochrane Central Register of Controlled Trials) search was performed up to July 2012, for randomized controlled trials presenting clinical, microbiological, immunological, and patient-centered data for the efficacy of aloe vera herbal dentifrices for controlling plaque and gingival inflammation in patients with gingivitis. RESULTS: From 79 titles and abstracts, eight full-text articles were screened and finally two randomized controlled trials were selected. These randomized controlled trials reported that aloe vera dentifrices were similar in efficacy to control dentifrices in effectively reducing plaque and gingival inflammation in gingivitis patients based on the assessment of clinical, microbiological, and patient-centered treatment outcomes. However, many important details (composition and characteristics of aloe vera and control dentifrices along with appropriate randomization, blinding, and outcomes assessed) were lacking in these trials, and therefore, the quality of reporting and methods was generally flawed with high risk of bias. CONCLUSION: Even though there are some promising results, the clinical effectiveness of aloe vera herbal dentifrices is not sufficiently defined at present and warrants further investigations based on reporting guidelines of herbal CONSORT statement.Copyright © 2013 John Wiley & Sons A/S. Publication Type Journal Article. Date Created 20140317 Year of Publication 2014




<10> Unique Identifier 24531599 Status In-Process Authors Khairwa A; Bhat M; Sharma R; Satish V; Maganur P; Goyal AK. Authors Full Name Khairwa, Abhishek; Bhat, Manohar; Sharma, Rajesh; Satish, V; Maganur, Prabhadevi; Goyal, Anil Kumar. Institution Khairwa,Abhishek. Department of Pedodontics with Preventive Dentistry, Jaipur Dental College and Hospital, Dhand, TehsiAmer, Jaipur-Delhi NH-11C, India. Title Clinical and radiographic evaluation of zinc oxide with aloe vera as an obturating material in pulpectomy: an in vivo study. Source Journal of the Indian Society of Pedodontics & Preventive Dentistry. 32(1):33-8, 2014 Jan-Mar. Abstract BACKGROUND: Pulp therapy for pulpally involved primary teeth continues to be a challenge to clinicians. One of the major areas of continued research is in the area of finding obturating materials to suit the specific properties of these teeth. Zinc oxide eugenol is used frequently in pulpectomy for the obturation of the primary teeth. AIMS: To evaluate clinically and radiographically a mixture of zinc oxide eugenol and aloe vera as an obturating material. MATERIALS AND METHODS: A total of 50 children, aged between 4 and 9 years, who were screened for unilateral or bilateral carious deciduous molars were studied. Out of these, 15 children were randomly selected for endodontic treatment. Obturation was done with a mixture of zinc oxide powder and aloe vera gel. Clinical and radiographic evaluation was done after 7 days, 1 month, 3 months, 6 months, and 9 months. The data were statistically analyzed. RESULTS AND CONCLUSION: Endodontic treatment using a mixture of zinc oxide powder and aloe vera gel in primary teeth has shown good clinical and radiographic success. A detailed observational study with longer follow-up will highlight the benefits of aloe vera in primary teeth as an obturating medium. Publication Type Journal Article. Date Created 20140217 Year of Publication 2014

<11> Unique Identifier 25031484 Status PubMed-not-MEDLINE Authors Badakhsh S; Eskandarian T; Esmaeilpour T. Authors Full Name Badakhsh, Samaneh; Eskandarian, Tahereh; Esmaeilpour, Tahereh. Institution Badakhsh,Samaneh. Department of Pediatric Dentistry, Zanjan University of Medical Sciences, Zanjan, Iran; Eskandarian,Tahereh. Department of Pediatric Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran; Esmaeilpour,Tahereh. Laboratory of Stem Cell Research, Department of Anatomy, Shiraz University of Medical Sciences, Shiraz, Iran. Title The use of aloe vera extract as a novel storage media for the avulsed tooth. Source Iranian Journal of Medical Sciences. 39(4):327-32, 2014 Jul. Other ID Source: NLM. PMC4100043 Abstract BACKGROUND: Tooth avulsion is one of the most severe dental traumas which most often occur in children. When immediate replantation is not possible, storage in a proper media may lead to a prolonged survival rate. Aloe Vera is a cactus like plant with green, tapered leaves that are filled with a transparent viscous gel. This medicinal plant has significant anti-inflammatory, antioxidant, antibacterial and antifungal effects. The purpose of this study was to assess the effectiveness of different concentrations of Aloe Vera extract compared to DMEM (cell culture medium) and egg white. METHODS: The periodontal ligament (PDL) cells were cultured and certain number of cells were treated with Aloe Vera extract (in four different concentrations), egg white and culture media for 1, 3, 6, and 9 hours. Cell viability was determined by using the (3-[4, 5-dimethylthiazolyl-2]-2, 5-diphenyltetrazolium bromide) assay. Moreover, One-way ANOVA and post hoc (LSD) test were used for analyzing the study groups. RESULTS: The results indicate that culture media and Aloe Vera extract (10, 30, and 50% concentration) were statistically similar and significantly preserved more PDL cells compared to other experimental storage media. CONCLUSION: Aloe Vera 10, 30, and 50% may be recommended as a suitable storage media for avulsed teeth. Publication Type Journal Article. Date Created




20140717 Year of Publication 2014 <12> Unique Identifier 24738089 Status PubMed-not-MEDLINE Authors Sahebi S; Khosravifar N; Sedighshamsi M; Motamedifar M. Authors Full Name Sahebi, S; Khosravifar, N; Sedighshamsi, M; Motamedifar, M. Institution Sahebi,S. Dept. of Endodontics, School of Dentistry, Shiraz University of Medical Sciences, Shiraz,Iran. Khosravifar,N. Postgraduate Student of Radiology, Dept. of Radiology, School of Dentistry, Shiraz University of Medical Sciences, Shiraz,Iran. Sedighshamsi,M. Dept. of Endodontics, School of Dentistry, Shiraz University of Medical Sciences, Shiraz,Iran. Motamedifar,M. Dept. of Microbiology, School of Medicine, Shiraz University of Medical Sciences, Shiraz,Iran. Title Comparison of the antibacterial effect of sodium hypochlorite and aloe vera solutions as root canal irrigants in human extracted teeth contaminated with enterococcus faecalis. Source Journal of Dentistry. 15(1):39-43, 2014 Mar. Other ID Source: NLM. PMC3986570 Abstract STATEMENT OF PROBLEM: The main purpose of a root canal treatment is to eliminate the bacteria and their products from the pulp space. Sodium hypochlorite has excellent antibacterial properties, but also some negative features. PURPOSE: The aim of the present study is to compare the antimicrobial effect of Aloe Vera solution with sodium hypochlorite on E.faecalis in the root canals of human extracted teeth. MATERIALS AND METHOD: Sixty human extracted single rooted teeth were selected for this in vitro study. The teeth recruited in this study had no cracks, internal resorption, external resorption and calcification. Enterococcus faecalis was injected in the root canals of all teeth. The teeth were then divided into three groups randomly. Each group consisted of 20 teeth that were all rinsed with one of the following solutions: sodium hypochlorite 2.5%, Aloe vera and normal saline. Subsequent to rinsing, root canals of all teeth were sampled. The samples were cultured and growth of the bacteria was assessed after 48 hours. The number of colonies of the bacteria was then counted.

RESULTS: The difference between the inhibitory effect of Aloe vera and normal saline on E.faecalis was not significant according to independent t-test (p= 0.966). The inhibitory effect of sodium hypochlorite on E.faecalis was much greater than that of Aloe vera and normal saline (p< 0.001). CONCLUSION: Aloe vera solution is not recommended as a root canal irrigator, but future studies are suggested to investigate the antibacterial effect of Aloe vera with longer duration of exposure and as an intra canal medicament. Publication Type Journal Article. Date Created 20140416 Year of Publication 2014 <13> Unique Identifier 23710575 Status MEDLINE Authors Chantarawaratit P; Sangvanich P; Banlunara W; Soontornvipart K; Thunyakitpisal P. Authors Full Name Chantarawaratit, P; Sangvanich, P; Banlunara, W; Soontornvipart, K; Thunyakitpisal, P. Institution Chantarawaratit,P. Faculty of Dentistry, Dental Biomaterials Program, Graduate School, Chulalongkorn University, Bangkok, Thailand; Department of Materials Science, Faculty of Science, Chulalongkorn University, Bangkok, Thailand. Title Acemannan sponges stimulate alveolar bone, cementum and periodontal ligament regeneration in a canine class II furcation defect model. Source Journal of Periodontal Research. 49(2):164-78, 2014 Apr. Local Messages THIS JOURNAL IS AVAILABLE IN THE BDA LIBRARY Abstract BACKGROUND AND OBJECTIVE: Periodontal disease is a common infectious disease, found worldwide, causing the destruction of the periodontium. The periodontium is a complex structure composed of both soft and hard tissues, thus an agent applied to regenerate the periodontium must be able to stimulate periodontal ligament, cementum and alveolar bone regeneration. Recent studies demonstrated that acemannan, a polysaccharide extracted from Aloe vera gel, stimulated both soft and hard tissue healing. This study investigated effect of acemannan as a bioactive molecule and scaffold for periodontal tissue regeneration. MATERIAL AND METHODS: Primary human periodontal ligament cells were treated with acemannan in vitro. New DNA synthesis, expression of growth/differentiation factor 5 and




runt-related transcription factor 2, expression of vascular endothelial growth factor, bone morphogenetic protein-2 and type I collagen, alkaline phosphatase activity, and mineralized nodule formation were determined using [(3)H]-thymidine incorporation, reverse transcription-polymerase chain reaction, enzyme-linked immunoabsorbent assay, biochemical assay and alizarin red staining, respectively. In our in vivo study, premolar class II furcation defects were made in four mongrel dogs. Acemannan sponges were applied into the defects. Untreated defects were used as a negative control group. The amount of new bone, cementum and periodontal ligament formation were evaluated 30 and 60 d after the operation. RESULTS: Acemannan significantly increased periodontal ligament cell proliferation, upregulation of growth/differentiation factor 5, runt-related transcription factor 2, vascular endothelial growth factor, bone morphogenetic protein 2, type I collagen and alkaline phosphatase activity, and mineral deposition as compared with the untreated control group in vitro. Moreover, acemannan significantly accelerated new alveolar bone, cementum and periodontal ligament formation in class II furcation defects. CONCLUSION: Our data suggest that acemannan could be a candidate biomolecule for periodontal tissue regeneration.Copyright © 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. Publication Type Journal Article. Research Support, Non-U.S. Gov't. Date Created 20140317 Year of Publication 2014 <14> Unique Identifier 24164309 Status MEDLINE Authors Mansour G; Ouda S; Shaker A; Abdallah HM. Authors Full Name Mansour, Ghada; Ouda, Soliman; Shaker, Ahmed; Abdallah, Hossam M. Institution Mansour,Ghada. Department of Oral Basic and Clinical Sciences, Faculty of Dentistry, King Abdulaziz University, Jeddah, Saudi Arabia; Department of Oral Medicine, Periodontology, Oral Diagnosis and Oral Radiology, Faculty of Dentistry, Alexandria University, Alexandria, Egypt. Title Clinical efficacy of new aloe vera- and myrrh-based oral mucoadhesive gels in the management of minor recurrent aphthous stomatitis: a randomized, double-blind, vehicle-controlled study. Source Journal of Oral Pathology & Medicine. 43(6):405-9, 2014 Jul.

Local Messages THIS JOURNAL IS AVAILABLE IN THE BDA LIBRARY Abstract OBJECTIVE: To evaluate the clinical efficacy, and safety of newly customized natural oral mucoadhesive gels, containing either aloe vera or myrrh as active ingredients, in the management of minor recurrent aphthous stomatitis (MiRAS). SUBJECTS AND METHODS: Ninety subjects with MiRAS were recruited from Oral Medicine Clinic, at Faculty of Dentistry, King Abdulaziz University, Saudi Arabia, for this randomized, double-blind, placebo-controlled study. Two new natural gels, containing aloe vera and myrrh, were prepared in a concentration of (0.5% w/w), in addition to a plain mucoadhesive gel used as a placebo. Patients with fresh ulcers (<48-h duration) were instructed to apply either one of the three gels four times a day for a period of 5 days. Clinical efficacy was investigated in the form of changes in ulcer size, pain intensity, erythema, and exudation at days 4 and 6 of study entry. Participants were interviewed for the emergence of any side effects. RESULTS: 76.6% of patients using aloe gel showed complete ulcer healing, 86.7%, and 80% of them revealed subsidence of erythema and exudation, respectively, especially at day 6 visit, whereas 76.7% of myrrh-treated patients revealed almost absence of pain at day 6. No side effects were encountered with the use of any of the three gels. CONCLUSION: The new formulated aloe- and myrrh-based gels proved to be effective in topical management of MiRAS. Aloe was superior in decreasing ulcer size, erythema, and exudation; whereas myrrh resulted in more pain reduction.Copyright © 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. Publication Type Comparative Study. Journal Article. Randomized Controlled Trial. Research Support, Non-U.S. Gov't. Date Created 20140703 Year of Publication 2014 <15> Unique Identifier 24795515 Status MEDLINE Authors Gupta RK; Gupta D; Bhaskar DJ; Yadav A; Obaid K; Mishra S. Authors Full Name Gupta, Rajendra Kumar; Gupta, Devanand; Bhaskar, Dara John; Yadav, Ankit; Obaid, Khursheed; Mishra, Sumit. Institution




Gupta,Rajendra Kumar. Principal, Government Postgraduate College, Lansdowne, Uttrakhand, India. Gupta,Devanand. Department of Public Health Dentistry, T.M.D.C. & R.C., Moradabad, Uttar Pradesh, India. Bhaskar,Dara John. Department of Public Health Dentistry, T.M.D.C. & R.C., Moradabad, Uttar Pradesh, India. Yadav,Ankit. Departmentof Orthodontics and Dentofacial Orthopedics, T.M.D.C. & R.C., Moradabad, Uttar Pradesh, India. Obaid,Khursheed. Departmentof Pedodontics and Preventive Dentistry, K.D Dental College and Hospital, Mathura, Uttar Pradesh, India. Mishra,Sumit. Department of Prosthodontics, T.M.D.C. & R.C., Moradabad, Uttar Pradesh, India. Title Preliminary antiplaque efficacy of aloe vera mouthwash on 4 day plaque re-growth model: randomized control trial. Source Ethiopian Journal of Health Sciences. 24(2):139-44, 2014 Apr. Other ID Source: NLM. PMC4006208 Abstract BACKGROUND: Due to increasing resistance to antibiotics and rising incidence of oral diseases, there is a need for alternative treatment modalities to combat oral diseases. The aim of the present study was to access the effect of Aloe vera mouthwash on the dental plaque in the experimental period of 4 days and to compare it with the bench mark control chlorhexidine and placebo (saline water). MATERIAL AND METHODS: A total of 300 systemically healthy subjects were randomly allocated into 3 groups: Aloe vera mouthwash group (n=100), control group (=100)-chlorhexidene group and saline water-Placebo (n=100). To begin with, Gingival index (GI) and plaque index (PI) were recorded. Then, baseline plaque scores were brought to zero by professionally cleaning the teeth with scaling and polishing. After randomization of the participants into three groups they were refrained from regular mechanical oral hygiene measures. Subjects were asked to swish with respective mouthwash (Aloe vera mouthwash, 0.2%chlorhexidine gluconate mouthwash, or normal saline) as per therapeutic dose for 4 days. RESULTS: The results showed that Aloe vera mouthrinse is equally effective in reducing plaque as Chlorhexidine compared to placebo over a period of 4 days. There was a significant reduction on plaque in Aloe vera and chlorhexidine groups and no statistically significant difference was observed among them (p>0.05). Aloe vera mouthwash showed no side effects. CONCLUSION: The results of the present study indicated that Aloe vera may prove an effective mouthwash due to its ability in reducing dental plaque. Publication Type Comparative Study. Journal Article. Randomized Controlled Trial.

Date Created 20140505 Year of Publication 2014 <16> Unique Identifier 22788669 Status In-Process Authors Baccaglini L; Thongprasom K; Carrozzo M; Bigby M. Authors Full Name Baccaglini, L; Thongprasom, K; Carrozzo, M; Bigby, M. Institution Baccaglini,L. Department of Epidemiology, University of Nebraska Medical Center, Omaha, NE, USA Department of Oral Medicine, Faculty of Dentistry, Chulalongkorn University, Bangkok, Thailand Department of Oral Medicine, Centre for Oral Health Research, Newcastle University, Newcastle upon Tyne, UK Department of Dermatology, Harvard Medical School and Beth Israel Deaconess Medical Center, Boston, MA, USA. Title Urban legends series: lichen planus. Source Oral Diseases. 19(2):128-43, 2013 Mar. Local Messages THIS JOURNAL IS AVAILABLE IN THE BDA LIBRARY Abstract Oral Diseases (2012) Lichen planus (LP) is a common disorder affecting the oral cavity (OLP) and skin. Despite intensive research, LP/OLP etiology and treatment remain controversial. We investigated four controversial topics: (i) Is hepatitis C virus (HCV) infection associated with LP and involved in its pathogenesis? (ii) Should all patients with LP be screened for HCV? (iii) Should patients with OLP have all their amalgam restorations removed? (iv) Are there any new treatments for OLP? Results from extensive literature searches suggested that: (i) Robust evidence from three meta-analyses indicate that HCV is associated with LP and might be involved in OLP pathogenesis (ii) It would be prudent to screen patients with LP/OLP at significant risk with an ELISA for HCV antibodies using country-specific screening strategies (iii) There is no evidence that either OLP or oral lichenoid lesions patients would routinely benefit from having all their amalgam restorations replaced. Weak evidence from potentially very biased, small, non-randomized, unblinded studies suggests that a small fraction of patients may benefit from targeted amalgam replacement. (iv) There is weak evidence that, among new OLP treatments, topical pimecrolimus, aloe vera, and oral curcuminoids may be useful. The development of specific formulations for oral delivery of topical medications is a promising field. Copyright © 2012 John Wiley & Sons A/S. Publication Type Journal Article.




Date Created 20131001 Year of Publication 2013 <17> Unique Identifier 24047829 Status In-Process Authors Doddanna SJ; Patel S; Sundarrao MA; Veerabhadrappa RS. Authors Full Name Doddanna, Sunitha Jagalur; Patel, Shilpa; Sundarrao, Madhusudan Astekar; Veerabhadrappa, Ravindra Setru. Institution Doddanna,Sunitha Jagalur. Department of Oral Pathology and Microbiology, Teerthanker Mahaveer Institute of Dental Sciences and Research Centre, Teerthanker Mahaveer University, Bagarpur, Delhi Road, Moradabad, Uttar Pradesh, India. Title Antimicrobial activity of plant extracts on Candida albicans: an in vitro study. Source Indian Journal of Dental Research. 24(4):401-5, 2013 Jul-Aug. Abstract BACKGROUND AND OBJECTIVES: Plants as sources of medicinal compounds have continued to play a predominant role in the maintenance of human health since ancient times. Even though several effective antifungal agents are available for oral candida infections, the failure is not uncommon because isolates of Candida albicans may exhibits resistance to the drug during therapy. The present study was conducted to evaluate the antimicrobial effects of few plant extracts on Candida albicans. An additional objective was to identify an alternative, inexpensive, simple, and effective method of preventing and controlling Candida albicans. MATERIALS AND METHODS: Fine texture powder or paste form of leaves was soaked in sterile distilled water and 100% ethyl alcohol, which were kept in refrigerator at 4degreeC for 24 h. Then filtrates were prepared and kept in a hot air oven to get a black shining crystal powder/paste form. Stock solutions of plant extracts were inoculated on petri plates containing species of Candida albicans and incubated at 25 +/- 2degreeC for 72 h. RESULTS: Alcoholic curry leaves showed the maximum zone of inhibition on Candida albicans followed by aqueous tea leaves. The other plant extracts like alcoholic onion leaves, alcoholic tea leaves, alcoholic onion bulb, alcoholic aloe vera, and alcoholic mint leaves also inhibited the growth of Candida albicans but lesser extent. CONCLUSION: The present study renders few medicinal plants as an alternative medicines to the field of dentistry which can be used adjunct to conventional therapy of oral candidasis.

Publication Type Journal Article. Date Created 20130919 Year of Publication 2013 <18> Unique Identifier 23433693 Status In-Process Authors Osso D; Kanani N. Authors Full Name Osso, Diane; Kanani, Nehal. Institution Osso,Diane. Full-time faculty member at the Community College of Denver Dental Hygiene Program. Title Antiseptic mouth rinses: an update on comparative effectiveness, risks and recommendations. Source Journal of Dental Hygiene. 87(1):10-8, 2013 Feb. Local Messages THIS JOURNAL IS AVAILABLE IN THE BDA LIBRARY Abstract PURPOSE: Antiseptic mouth rinses are widely recommended and marketed to improve oral health. This article summarizes current studies on the comparative effectiveness of selected antiseptic mouth rinses in controlling plaque and gingivitis, as well as risks associated with daily exposure, including salivary flow rate, oral cancer and wear of composite restorations. METHODS: Electronic database searches were conducted using Google Scholar and PubMed to identify articles comparing the effectiveness of 4 commercially marketed antiseptic mouth rinses differing in active ingredients (0.12% chlorhexidine gluconate, essential oils (menthol, thymol and eucalyptol) and methyl salicylate, 0.7% cetylpyridinium chloride and 20% aloe vera gel) for controlling plaque and gingivitis. Criteria for inclusion included controlled clinical trials and systematic reviews appearing in English language publications evaluating the comparative effectiveness of the mouth rinses in controlling plaque and gingivitis, as well as risks associated with daily usage. RESULTS: The majority of studies have shown mouth rinses containing chlorhexidine gluconate or essential oils and methyl salicylate provide clinically significant anti-gingivitis and anti-plaque benefits. Cetylpyridinium chloride has been found to provide only limited clinical benefits compared to inactive control mouth rinse. Inadequate evidence is available to evaluate the clinical effectiveness of aloe vera gel. Chlorhexidine, essential oils and




cetylpyridinium have been found to be safe. However, limited data are available on the effects of the mouth rinse on wear patterns of dental restorations. Studies reviewed reported no significant difference in salivary flow rate related to alcohol based mouth rinse. CONCLUSION: Research supports the effectiveness of antiseptic mouth rinses in reducing plaque and gingivitis as an adjunct to home care. Insufficient evidence is available to support the claim that oral antiseptics can reduce the risk of developing periodontitis or the rate of progression of periodontitis. Publication Type Journal Article. Date Created 20130225 Year of Publication 2013 <19> Unique Identifier 24174720 Status PubMed-not-MEDLINE Authors Ajmera N; Chatterjee A; Goyal V. Authors Full Name Ajmera, Neha; Chatterjee, Anirban; Goyal, Vikas. Institution Ajmera,Neha. Department of Periodontics, Vaidik Dental College and Research Center, Daman, Union Territory, India. Title Aloe vera: It's effect on gingivitis. Source Journal of Indian Society of Periodontology. 17(4):435-8, 2013 Jul. Other ID Source: NLM. PMC3800403 Abstract OBJECTIVE: Aloe vera is the oldest medicinal plant that has maintained its popularity over the course of time. It is widely known for its medicinal uses in wound healing, as an analgesic, and for its anti-inflammatory properties. AIM: The aim of this study is to evaluate the anti-inflammatory property of aloe vera mouthwash on plaque-induced gingivitis. MATERIALS AND METHODS: Forty-five patients who were diagnosed with plaque-induced gingivitis were included in the study. They were divided into three groups with fifteen patients in each group. Group 1 was asked to rinse with 10 ml of aloe vera mouthwash twice daily for three months. Group 2 were treated with scaling only. Group 3 patients were asked to rinse with aloe vera mouthwash and scaling was done. The clinical changes were evaluated with

Loe and Silness gingival index (1963) and Muhlemann and Son's Sulcus bleeding index (1971) at baseline, after one month and three months, respectively. RESULTS: The data obtained was compared statistically. The paired 't' test was done for intragroup comparison and one-way analysis of variance with a post hoc Tukey test was used for intergroup comparison. The data was obtained at the baseline, end of first month, and end of the third month. The result suggested reduction in gingival inflammation in all the three groups, but it was more in the aloe vera mouthwash and scaling group. Hence, it was concluded that aloe vera had a significant anti-inflammatory property. Thus, it can be used as an adjunct to mechanical therapy for treating plaque-induced gingivitis. Publication Type Journal Article. Date Created 20131031 Year of Publication 2013 <20> Unique Identifier 24089615 Status PubMed-not-MEDLINE Authors Pareek S; Nagaraj A; Sharma P; Atri M; Walia S; Naidu S; Yousuf A. Authors Full Name Pareek, Sonia; Nagaraj, Anup; Sharma, Prateek; Atri, Mansi; Walia, Satinder; Naidu, Shravani; Yousuf, Asif. Institution Pareek,Sonia. Public Health Dentistry, Jaipur Dental College, Dhand-AmerJaipur Delhi, NH-8, Jaipur 303101, India. Title Disinfection of dental unit water line using aloe vera: in vitro study. Source International Journal of Dentistry. 2013:618962, 2013. Other ID Source: NLM. PMC3781845 Abstract Context. Dental unit waterlines may be heavily contaminated with microorganisms and are a potential source of infection for both practicing staff and immunocompromised patients particularly. Contamination of dental unit water lines could be inhibited with the use of disinfectants. The present study investigates the effect of aloe-vera-based disinfectant in reducing the microbial growth in dental unit water lines (DUWLs). Aims. To compare the efficacy of aloe vera, hydrogen peroxide (H2O2), and 5% sodium hypochlorite (NaOCl) in controlling microbial contamination of DUWLs. Materials and Methods. After obtaining baseline water samples, the dental unit waterlines were treated with aloe vera, 10% hydrogen peroxide, and 5% sodium hypochlorite. Each of the three disinfectants was used in increasing




concentrations and their inhibiting effect was compared. Water samples were analyzed for microbiological quality by the total viable count (TVC) method. Statistical Analysis Used. SPSS 16. Results. There was significant reduction in mean CFU/ml when treated with disinfectants each for a period of one week. Aloe-vera solution was found to be the most effective in reducing the microbial colonies. Conclusions. Improving the water quality from dental unit water lines is of considerable importance; chemical-based disinfectants can be replaced with herbal disinfectants for treating microbial contamination in dental unit waterlines. Publication Type Journal Article. Date Created 20131003 Year of Publication 2013 <21> Unique Identifier 23668304 Status MEDLINE Authors Thongprasom K; Prapinjumrune C; Carrozzo M. Authors Full Name Thongprasom, Kobkan; Prapinjumrune, Chanwit; Carrozzo, Marco. Institution Thongprasom,Kobkan. Oral Medicine Department, Faculty of Dentistry, Chulalongkorn University, Bangkok, Thailand. Title Novel therapies for oral lichen planus. [Review] Source Journal of Oral Pathology & Medicine. 42(10):721-7, 2013 Nov. Local Messages THIS JOURNAL IS AVAILABLE IN THE BDA LIBRARY Abstract Oral lichen planus (OLP) is a chronic mucocutaneous disorder commonly found in middle-aged women. Despite the progress in research and advance in knowledge on OLP, a successful management is still difficult to achieve. The main aim of OLP treatment is to control the symptoms of the affected patients. Steroids and other immunosuppressive drugs have been recommended and widely used in the treatment of OLP. Topical corticosteroids are the mainstay of OLP treatment, but strong evidence on their effectiveness is lacking. The effectiveness of alternative ways of managing OLP has been recently reported. Topical aloe vera, topical pimecrolimus and oral curcuminoids are the most promising of the new treatment modalities. Other interesting modalities are topically applied thalidomide and amlexanox. Nevertheless, the careful assessment between the risks and benefits of these drugs is crucial and larger and well-conducted trials need to confirm the above encouraging results. Copyright © 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Publication Type Journal Article. Review. Date Created 20140303 Year of Publication 2013 <22> Unique Identifier 24245466 Status MEDLINE Authors Patil BA; Bhaskar HP; Pol JS; Sodhi A; Madhu AV. Authors Full Name Patil, Bharati A; Bhaskar, Hebbar Pragati; Pol, Jyoti S; Sodhi, Amandeep; Madhu, Asha V. Institution Patil,Bharati A. Department of Oral Medicine and Radiology, Oxford Dental College and Hospital, Bangalore, India. [email protected] Title Aloe vera as cure for lichen planus. Source New York State Dental Journal. 79(5):65-8, 2013 Aug-Sep. Local Messages THIS JOURNAL IS AVAILABLE IN THE BDA LIBRARY Abstract Oral lichen planus is a difficult condition to treat because of its chronic nature. Various treatment modalities have resulted in partial regression of symptoms but not a complete cure. Aloe vera, a product with minimal adverse effects, can be tried to treat this disorder. A 38-year-old male patient diagnosed with lichen planus of the skin and the oral mucosa was suffering from severe pain and a burning sensation intraorally and pruritus of the skin lesions. Considering the extensive involvement, an herbal alternative was considered. The patient was prescribed aloe vera juice and gel application for two months. At the nine-month follow-up, the patient was symptom-free and totally cured of the intraoral and skin lesions. Publication Type Case Reports. Journal Article. Date Created 20131119 Year of Publication 2013 <23> Unique Identifier 24237724 Status




MEDLINE Authors Alam S; Ali I; Giri KY; Gokkulakrishnan S; Natu SS; Faisal M; Agarwal A; Sharma H. Authors Full Name Alam, Sarwar; Ali, Iqbal; Giri, K Y; Gokkulakrishnan, S; Natu, Subodh S; Faisal, Mohammad; Agarwal, Anshita; Sharma, Himanshu. Institution Alam,Sarwar. Senior Lecturer, Department of Oral and Maxillofacial Surgery, Institute of Dental Sciences, Bareilly, Uttar Pradesh. Electronic address: [email protected]. Title Efficacy of aloe vera gel as an adjuvant treatment of oral submucous fibrosis. Source Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology. 116(6):717-24, 2013 Dec. Abstract OBJECTIVE: Definitive therapy is not defined for the management of oral submucous fibrosis (OSMF). This study evaluated the efficacy of aloe vera gel as an adjuvant treatment of OSMF. STUDY DESIGN: A double-blind, placebo-controlled, parallel-group randomized controlled trial was conducted on 60 subjects with OSMF divided into medicinal treatment (submucosal injection of hyaluronidase and dexamethasone, n = 30) and surgical treatment (n = 30) categories. Each category was randomly divided into groups A (with aloe vera, n = 15 per category) and B (without aloe vera, n = 15 per category). Follow-up assessment for various symptoms was performed, and results were analyzed using paired and unpaired Student t tests. RESULTS: The group receiving aloe vera had a significant improvement in most symptoms of OSMF (P < .01) compared with the non-aloe vera group, in both the medicinal and surgical categories. CONCLUSIONS: Aloe vera gel was effective as an adjuvant in treatment of OSMF.Copyright © 2013 Elsevier Inc. All rights reserved. Publication Type Journal Article. Randomized Controlled Trial. Date Created 20131118 Year of Publication 2013 <24> Unique Identifier 23852230 Status MEDLINE Authors Bhardwaj A; Velmurugan N; Sumitha; Ballal S.

Authors Full Name Bhardwaj, Anuj; Velmurugan, Natanasabapathy; Sumitha; Ballal, Suma. Institution Bhardwaj,Anuj. Department of Conservative Dentistry and Endodontics, Modern Dental College and Research Centre, Gandhi Nagar, Indore, Madhya Pradesh, India. Title Efficacy of passive ultrasonic irrigation with natural irrigants (Morinda citrifolia juice, Aloe Vera and Propolis) in comparison with 1% sodium hypochlorite for removal of E. faecalis biofilm: an in vitro study. Source Indian Journal of Dental Research. 24(1):35-41, 2013 Jan-Feb. Abstract AIM: Present study evaluated the efficacy of natural derivative irrigants, Morinda citrifolia juice (MCJ), Aloe Vera and Propolis in comparison to 1% sodium hypochlorite with passive ultrasonic irrigation for removal of the intraradicular E. faecalis biofilms in extracted single rooted human permanent teeth. MATERIALS AND METHODS: Biofilms of E. faecalis were grown on the prepared root canal walls of 60 standardized root halves which were longitudinally sectioned. These root halves were re-approximated and the samples were divided into five groups of twelve each. The groups were, Group A (1% NaOCl), Group B (MCJ), Group C (Aloe vera), Group D (Propolis) and Group E (Saline). These groups were treated with passive ultrasonic irrigation (PUI) along with the respective irrigants. The root halves were processed for scanning electron microscopy. Three images (X2.5), coronal, middle and apical, were taken for the twelve root halves in each of the five groups. The images were randomized and biofilm coverage assessed independently by three calibrated examiners, using a four-point scoring system. RESULTS: 1% NaOCl with passive ultrasonic irrigation (PUI) was effective in completely removing E. faecalis biofilm and was superior to the natural irrigants like MCJ, Aloe vera and Propolis tested in this study. CONCLUSION: 1% NaOCl used along with passive ultrasonic irrigation was effective in completely removing E. faecalis biofilm when compared to natural irrigants (MCJ, Aloe Vera and Propolis). Publication Type Comparative Study. Journal Article. Date Created 20130715 Year of Publication 2013 <25> Unique Identifier 23485568 Status




MEDLINE Authors Tuzuner T; Ulusoy AT; Baygin O; Yahyaoglu G; Yalcin I; Buruk K; Nicholson J. Authors Full Name Tuzuner, Tamer; Ulusoy, Ayca Tuba; Baygin, Ozgul; Yahyaoglu, Gorkem; Yalcin, Ilkay; Buruk, Kurtulus; Nicholson, John. Institution Tuzuner,Tamer. Department of Pediatric Dentistry, Faculty of Dentistry, Karadeniz Technical University, Trabzon, Turkey. [email protected] Title Direct and transdentinal (indirect) antibacterial activity of commercially available dental gel formulations against Streptococcus mutans. Source Medical Principles & Practice. 22(4):397-401, 2013. Abstract OBJECTIVE: To evaluate the direct and transdentinal (indirect) agar diffusion antibacterial activity of different commercially available antibacterial dental gel formulations against Streptococcus mutans. MATERIALS AND METHODS: The commercially available dental gel formulations were Corsodyl (COG, 1% chlorhexidine), Cervitec (CEG, 0.2% chlorhexidine + 0.2% sodium fluoride), Forever Bright (FOB, aloe vera), Gengigel (GEG, 0.2% hyaluronic acid), 35% phosphoric acid gel and distilled water (control). Direct agar diffusion was performed by isolating three wells from brain-heart infusion agar plates using sterile glass pipettes attached to a vacuum pump and adding 0.1 ml of the gels to each well. Transdentinal (indirect) agar diffusion was performed by applying gel to 0.2- and 0.5-mm-thick human dentin discs previously etched with phosphoric acid and rinsed with distilled water. Zones formed around the wells and the dentin discs were measured and analyzed using Kruskal-Wallis and Mann-Whitney U tests with Bonferroni correction (p < 0.01). RESULTS: Direct agar diffusion tests showed significant differences among all gel formulations (p < 0.01) except for COG and CEG (p > 0.01). COG and CEG exhibited higher antibacterial effects compared to FOB and GEG (p < 0.01) in both direct and transdentinal (indirect) testing procedures. GEG did not show any antimicrobial activity in transdentinal (indirect) testing. CONCLUSION: Commercially available dental gels inhibited S. mutans, which may indicate their potential as cavity disinfectants.Copyright © 2013 S. Karger AG, Basel. Publication Type Journal Article. Date Created 20130611 Year of Publication 2013 <26>

Unique Identifier 23739849 Status MEDLINE Authors Valera MC; Maekawa LE; de Oliveira LD; Jorge AO; Shygei E; Carvalho CA. Authors Full Name Valera, Marcia Carneiro; Maekawa, Lilian Eiko; de Oliveira, Luciane Dias; Jorge, Antonio Olavo Cardoso; Shygei, Erika; Carvalho, Claudio Antonio Talge. Institution Valera,Marcia Carneiro. Restorative Dentistry Department, Univ. Estadual Paulista, Sao Jose dos Campos, Sao Paulo, SP, Brazil. [email protected] Title In vitro antimicrobial activity of auxiliary chemical substances and natural extracts on Candida albicans and Enterococcus faecalis in root canals. Source Journal of Applied Oral Science. 21(2):118-23, 2013 Mar-Apr. Other ID Source: NLM. PMC3881874 Abstract OBJECTIVE: The aim of this study was to evaluate the antimicrobial activity of auxiliary chemical substances and natural extracts on Candida albicans and Enterococcus faecalis inoculated in root canals. MATERIAL AND METHODS: Seventy-two human tooth roots were contaminated with C. albicans and E. faecalis for 21 days. The groups were divided according to the auxiliary chemical substance into: G1) 2.5% sodium hypochlorite (NaOCl), G2) 2% chlorhexidine gel (CHX), G3) castor oil, G4) glycolic Aloe vera extract, G5) glycolic ginger extract, and G6) sterile saline (control). The samples of the root canal were collected at different intervals: confirmation collection, at 21 days after contamination; 1st collection, after instrumentation; and 2nd collection, seven days after instrumentation. Microbiological samples were grown in culture medium and incubated at 37degreeC for 48 hours. RESULTS: The results were submitted to the Kruskal-Wallis and Dunn (5%) statistical tests. NaOCl and CHX completely eliminated the microorganisms of the root canals. Castor oil and ginger significantly reduced the number of CFU of the tested bacteria. Reduction of CFU/mL at the 1st and 2nd collections for groups G1, G2, G3 and G4 was greater in comparison to groups G5 and G6. CONCLUSION: It was concluded that 2.5% sodium hypochlorite and 2% chlorhexidine gel were more effective in eliminating C. albicans and E. faecalis, followed by the castor oil and glycolic ginger extract. The Aloe vera extract showed no antimicrobial activity. Publication Type Evaluation Studies. Journal Article. Research Support, Non-U.S. Gov't. Date Created 20130606




Year of Publication 2013 <27> Unique Identifier 22957483 Status MEDLINE Authors Lopez-Jornet P; Camacho-Alonso F; Molino-Pagan D. Authors Full Name Lopez-Jornet, Pia; Camacho-Alonso, Fabio; Molino-Pagan, Diana. Institution Lopez-Jornet,Pia. Department of Oral Medicine, Faculty of Medicine and Dentistry, University of Murcia, Murcia, Spain. [email protected] Title Prospective, randomized, double-blind, clinical evaluation of Aloe vera Barbadensis, applied in combination with a tongue protector to treat burning mouth syndrome. Source Journal of Oral Pathology & Medicine. 42(4):295-301, 2013 Apr. Local Messages THIS JOURNAL IS AVAILABLE IN THE BDA LIBRARY Abstract OBJECTIVES: The aim of this study was to evaluate the efficacy of aloe vera (AV) applied in combination with a tongue protector, comparing this with a placebo. METHODS: A total of 75 patients with burning mouth syndrome (BMS) were divided into three groups randomly: Group I (tongue protector three times a day), Group II (tongue protector and 0.5 ml AV at 70% three times a day) and Group III (tongue protector and 0.5 ml placebo three times a day). Symptoms were evaluated by visual analogue scale (VAS), while patient psychological profiles were assessed using the Hospital Anxiety-Depression scale and their quality of life using the Oral Health Impact Profile 49 (OHIP-49). Treatment continued for 3 months. RESULTS: Visual analogue scale pain values improved for all three study groups but without statistically significant differences between the groups (P = 0.210). Regarding quality of life, no significant differences were found between groups with the exception of the OHIP-49 score for handicap. The overall clinical improvement was greater for Group II, with a difference almost reaching significance. CONCLUSIONS: The concomitant prescription of tongue protector and AV is effective for treating patients with BMS.Copyright © 2012 John Wiley & Sons A/S. All rights reserved. Publication Type Comparative Study. Journal Article. Randomized Controlled Trial. Date Created 20130404

Year of Publication 2013 <28> Unique Identifier 23421308 Status MEDLINE Authors Namiranian H; Serino G. Authors Full Name Namiranian, Homa; Serino, Giovanni. Institution Namiranian,Homa. Public Dental Service, Ulricehamn, Sweden. Title The effect of a toothpaste containing aloe vera on established gingivitis. Source Swedish Dental Journal. 36(4):179-85, 2012. Local Messages THIS JOURNAL IS AVAILABLE IN THE BDA LIBRARY Abstract The aim of the study was to evaluate the effect of a toothpaste containing high concentrations of Aloe vera on the reduction of plaque and gingivitis in patients attending regular dental care by a dental hygienist. Fifteen subjects participated in this randomized, double-blind, intra-individual and controlled clinical study. Participants were non-smokers, with signs of gingivitis (bleeding index 30%) and no signs of periodontitis. Subjects were followed for three 6-month periods during which they used either their own toothpaste, or an Aloe vera or a control toothpaste. Plaque and gingival indices were recorded atthe start and end of each period. There was a statistically and clinically significant reduction of about 20% of the plaque and gingivitis indices at the end of the clinical trial compared to baseline values, but no differences between the Aloe vera and the control toothpaste. It may be concluded that in patients motivated to improve their oral hygiene habits, the use of a toothpaste containing Aloe Vera showed no additional effect on plaque and gingivitis compared to a control toothpaste. Publication Type Journal Article. Randomized Controlled Trial. Research Support, Non-U.S. Gov't. Date Created 20130220 Year of Publication 2012 <29> Unique Identifier 22650317 Status MEDLINE




Authors Sudarshan R; Annigeri RG; Sree Vijayabala G. Authors Full Name Sudarshan, Ramachandran; Annigeri, Rajeshwari G; Sree Vijayabala, G. Institution Sudarshan,Ramachandran. Department of Oral Medicine and Radiology, Sibar Institute of Dental Sciences, Guntur, Andhra Pradesh, India. Title Aloe vera in the treatment for oral submucous fibrosis - a preliminary study. Source Journal of Oral Pathology & Medicine. 41(10):755-61, 2012 Nov. Local Messages THIS JOURNAL IS AVAILABLE IN THE BDA LIBRARY Abstract BACKGROUND AND OBJECTIVES: Oral submucous fibrosis (OSMF) is a potentially malignant disorder of the oral mucosa, mainly associated with the practice of chewing gutka and betel quid. The pathogenesis is obscure, and till date, no definitive therapy is available for the management of OSMF. Hence, this preliminary study was carried out to compare the efficacy of Aloe vera with antioxidants in the treatment for OSMF. METHODS: Twenty study subjects with OSMF were included in the study. Patients were divided into two groups. There were 10 patients in each group; group A subjects received 5 mg of aloe vera gel to be applied topically three times daily for 3 months and group B subjects received antioxidant capsules twice daily for 3 months. The results were analyzed with paired 't' test and unpaired 't' test. RESULTS: Aloe vera responded better in all the parameters assessed and responded in all the clinicohistopathological stages particularly in those with mild-stage clinically and early-stage histopathologically. Aloe vera showed a statistically significant reduction in burning sensation (P = 0.008), improvement in mouth opening (P = 0.02), and cheek flexibility (P = 0.01) on comparing with the antioxidant group. INTERPRETATION AND CONCLUSION: Overall assessment of the parameters depicted that Aloe vera group showed a better treatment response compared to the antioxidants group. It reduces the burning sensation and improves mouth opening thereby enhanced the patients' compliance. It proves to be a relatively safe, can be applied topically, easily available, economical, noninvasive, and efficacious in the treatment for OSMF.Copyright © 2012 John Wiley & Sons A/S. Publication Type Journal Article. Randomized Controlled Trial. Research Support, Non-U.S. Gov't. Date Created 20121105 Year of Publication 2012 <30>

Unique Identifier 23041995 Status MEDLINE Authors Reddy RL; Reddy RS; Ramesh T; Singh TR; Swapna LA; Laxmi NV. Authors Full Name Reddy, Reddy Lavanya; Reddy, Reddy Sudhakara; Ramesh, Tatapudi; Singh, Thakuri Rajesh; Swapna, Lingam Amara; Laxmi, Nimma Vijaya. Institution Reddy,Reddy Lavanya. Department of Oral Medicine and Radiology, Vishnu Dental College, Bhimavaram, Andhra Pradesh, India. [email protected] Title Randomized trial of aloe vera gel vs triamcinolone acetonide ointment in the treatment of oral lichen planus. Source Quintessence International. 43(9):793-800, 2012 Oct. Local Messages THIS JOURNAL IS AVAILABLE IN THE BDA LIBRARY Abstract OBJECTIVE: To determine the effectiveness of aloe vera gel in the treatment of oral lichen planus when compared with triamcinolone acetonide. METHOD AND MATERIALS: A randomized, double-blind, clinical trial was designed. The study sample constituted 40 patients (23 males and 17 females) who were randomly divided into two equal groups. Group A patients received aloe vera gel, while group B patients received triamcinolone acetonide. RESULTS: Forty patients were included in the study. Most of the sample presented with erosive (n = 18) and atrophic (n = 14) variants of oral lichen planus. When clinical signs and symptoms were observed after 8 weeks of therapy, it was determined that aloe vera gel was more effective than triamcinolone acetonide in the treatment of oral lichen planus. CONCLUSION: Aloe vera gel can be considered a safe alternative treatment for oral lichen planus. Publication Type Comparative Study. Journal Article. Randomized Controlled Trial. Date Created 20121008 Year of Publication 2012 <31> Unique Identifier 22087805 Status




MEDLINE Authors Pradeep AR; Agarwal E; Naik SB. Authors Full Name Pradeep, A R; Agarwal, Esha; Naik, Savitha B. Institution Pradeep,A R. Department of Periodontics, Government Dental College and Research Institute, Fort, Bangalore, Karnataka, India. [email protected] Title Clinical and microbiologic effects of commercially available dentifrice containing aloe vera: a randomized controlled clinical trial. Source Journal of Periodontology. 83(6):797-804, 2012 Jun. Local Messages THIS JOURNAL IS AVAILABLE IN THE BDA LIBRARY Abstract BACKGROUND: Certain plants used in folk medicine serve as a source of therapeutic agents that have antimicrobial and other multipotential effects. This prospective, randomized, placebo, and positively controlled clinical trial was designed to evaluate the clinical and microbiologic effects of a commercially available dentifrice containing aloe vera on the reduction of plaque and gingival inflammation in patients with gingivitis. METHODS: Ninety patients diagnosed with chronic generalized gingivitis were selected and randomly divided into three groups: group 1, placebo toothpaste; group 2, toothpaste containing aloe vera; and group 3, toothpaste with polymer and fluoride containing triclosan. Clinical evaluation was undertaken using a gingival index, plaque was assessed using a modification of the Quigley-Hein index, and microbiologic counts were assessed at baseline, 6 weeks, 12 weeks, and 24 weeks. A subjective evaluation was also undertaken by questionnaire. RESULTS: Toothpaste containing aloe vera showed significant improvement in gingival and plaque index scores as well as microbiologic counts compared with placebo dentifrice. These improvements were comparable to those achieved with toothpaste containing triclosan. CONCLUSION: Toothpaste containing aloe vera may be a useful herbal formulation for chemical plaque control agents and improvement in plaque and gingival status. Publication Type Comparative Study. Journal Article. Randomized Controlled Trial. Date Created 20120531 Year of Publication 2012 <32> Unique Identifier 22466882

Status MEDLINE Authors Fani M; Kohanteb J. Authors Full Name Fani, Mohammadmehdi; Kohanteb, Jamshid. Institution Fani,Mohammadmehdi. Department of Oral Medicine, School of Dentistry, Shiraz University of Medical Sciences, Iran. [email protected] Title Inhibitory activity of Aloe vera gel on some clinically isolated cariogenic and periodontopathic bacteria. Source Journal of Oral Science. 54(1):15-21, 2012 Mar. Local Messages HELD AT BDA INFORMATION CENTRE FROM 2000 ONWARDS Abstract Aloe vera is a medicinal plant with anti-inflammatory, antimicrobial, antidiabetic and immune-boosting properties. In the present study we investigated the inhibitory activities of Aloe vera gel on some cariogenic (Streptococcus mutans), periodontopathic (Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis) and an opportunistic periodontopathogen (Bacteroides fragilis) isolated from patients with dental caries and periodontal diseases. Twenty isolates of each of these bacteria were investigated for their sensitivity to Aloe vera gel using the disk diffusion and microdilution methods. S. mutans was the species most sensitive to Aloe vera gel with a MIC of 12.5 micro g/ml, while A. actinomycetemcomitans, P. gingivalis, and B. fragilis were less sensitive, with a MIC of 25-50 micro g/ml (P < 0.01). Based on our present findings it is concluded that Aloe vera gel at optimum concentration could be used as an antiseptic for prevention of dental caries and periodontal diseases. Publication Type Journal Article. Research Support, Non-U.S. Gov't. Date Created 20120402 Year of Publication 2012 <33> Unique Identifier 22437675 Status MEDLINE Authors Bertolini PF; Biondi Filho O; Pomilio A; Pinheiro SL; Carvalho MS. Authors Full Name Bertolini, Patricia Fernanda Roesler; Biondi Filho, Oswaldo; Pomilio, Arnaldo; Pinheiro, Sergio Luiz; Carvalho, Meghi Silva de.




Institution Bertolini,Patricia Fernanda Roesler. Department of Periodontics, Paulista University, Sorocaba, Brazil. [email protected] Title Antimicrobial capacity of Aloe vera and propolis dentifrice against Streptococcus mutans strains in toothbrushes: an in vitro study. Source Journal of Applied Oral Science. 20(1):32-7, 2012 Feb. Other ID Source: NLM. PMC3928769 Abstract OBJECTIVES: This study evaluated in vitro the efficiency of Aloe vera and propolis dentifrice on reducing the contamination of toothbrush bristles by a standard strain of Streptococcus mutans (ATCC 25175; SM), after toothbrushing. MATERIAL AND METHODS: Fifteen sterile toothbrushes were randomly divided into 5 toothbrushing groups: I (negative control): without dentifrice; II: with fluoridated dentifrice; III: with triclosan and gantrez dentifrice; IV (positive control): without dentifrice and irrigation with 10 mL of 0.12% chlorhexidine gluconate; V: with Aloe vera and propolis dentifrice. In each group, 1 sterile bovine tooth was brushed for 1 min, where the toothbrush bristles were contaminated with 25 micro L of SM. After toothbrushing, the bristles were stored in individual test tubes with 3 mL of BHI under anaerobiosis of 37degreeC for 48 h. Then, they were seeded with sterile swab in triplicate in the Mitis salivarius - Bacitracin culture medium. The samples were kept under anaerobiosis of 37degreeC for 48 h. Scores were used to count the number of colony forming units (cfu). The results were submitted to the Mann-Whitney statistical test at 5% significance level. RESULTS: There was statistically significant difference (p<0.05) for the reduction of bristle contamination comparing groups II, III, IV and V to group I. CONCLUSIONS: It may be stated that after toothbrushing, the Aloe vera and propolis dentifrice reduced the contamination of toothbrush bristles by SM, without differentiation from the other chemical agents used. Publication Type Journal Article. Date Created 20120322 Year of Publication 2012 <34> Unique Identifier 22028505 Status PubMed-not-MEDLINE Authors

Bhat G; Kudva P; Dodwad V. Authors Full Name Bhat, Geetha; Kudva, Praveen; Dodwad, Vidya. Institution Bhat,Geetha. Department of Periodontics, Jaipur Dental College, Jaipur, Rajasthan, India. Title Aloe vera: Nature's soothing healer to periodontal disease. Source Journal of Indian Society of Periodontology. 15(3):205-9, 2011 Jul. Other ID Source: NLM. PMC3200013 Abstract BACKGROUND: Recent interest and advances in the field of alternative medicine has promoted the use of various herbal and natural products for multiple uses in the field of medicine. Aloe vera is one such product exhibiting multiple benefits and has gained considerable importance in clinical research. This clinical study focuses on Aloe vera and highlights its property when used as a medicament in the periodontal pocket. MATERIALS AND METHODS: A total number of 15 subjects were evaluated for clinical parameters like plaque index, gingival index, probing pocket depth at baseline, followed by scaling and root planing (SRP). Test site comprised of SRP followed by intra-pocket placement of Aloe vera gel, which was compared with the control site in which only SRP was done, and clinical parameters were compared between the two sites at one month and three months from baseline. RESULTS: Results exhibited encouraging findings in clinical parameters of the role of Aloe vera gel as a drug for local delivery. CONCLUSION: We conclude that subgingival administration of Aloe vera gel results in improvement of periodontal condition. Aloe vera gel can be used as a local drug delivery system in periodontal pockets. Publication Type Journal Article. Date Created 20111026 Year of Publication 2011 <35> Unique Identifier 22117784 Status MEDLINE Authors Taheri JB; Azimi S; Rafieian N; Zanjani HA. Authors Full Name




Taheri, Jamile B; Azimi, Somayyeh; Rafieian, Nasrin; Zanjani, Hosein Akhavan. Institution Taheri,Jamile B. Oral Medicine, Shahid Beheshti University of Medical Science, Tehran, Iran. Title Herbs in dentistry. [Review] Source International Dental Journal. 61(6):287-96, 2011 Dec. Local Messages THIS JOURNAL IS AVAILABLE IN THE BDA LIBRARY Abstract Herbs have been used for centuries to prevent and control disease. Herbal extracts are effective because they interact with specific chemical receptors within the body and are in a pharmacodynamic sense, drugs themselves. By using herbal medicines, patients have averted the many side effects that generally come with traditional medicines, but this does not mean that side effects do not occur. Only knowledgeable practitioners can prescribe the right herb and its proper dosage. Herbal medicines had been considered in every culture, however, pharmaceutical companies overturned this type of thinking. Now, pharmaceuticals are called traditional and herbs are libeled as the 'alternative'. The biggest challenge and problem is lack of information about the effect of herbs in oral tissues, mechanism of effect, and side effects. Several popular conventional drugs on the market are derived from herbs. These include aspirin (from white willow bark), digitalis (from foxglove), and sudafed (modelled after a component in the plant ephedra). Herbal products can vary in their potency. Therefore, care must be taken in selecting herbs, even so, herbal medicines have dramatically fewer side effects and are safer to use than conventional medications. The herbs described in this article are Bloodroot, Caraway, Chamomile, Echinacea, Myrrh, Peppermint, Rosemary, Sage, Thyme, Aloe Vera, Propolis, and a summary of other herbs that are useful in dentistry. Herbs may be good alternatives to current treatments for oral health problems but it is clear that we need more research.Copyright © 2011 FDI World Dental Federation. Publication Type Journal Article. Review. Date Created 20111128 Year of Publication 2011 <36> Unique Identifier 21516276 Status MEDLINE Authors Bidra AS; Tarrand JJ; Roberts DB; Rolston KV; Chambers MS. Authors Full Name Bidra, Avinash S; Tarrand, Jeffery J; Roberts, Dianna B; Rolston, Kenneth V; Chambers, Mark S.

Institution Bidra,Avinash S. Department of Prosthodontics, University of Texas Health Science Center, San Antonio, TX, USA. [email protected] Title Antimicrobial efficacy of oral topical agents on microorganisms associated with radiated head and neck cancer patients: an in vitro study. Source Quintessence International. 42(4):307-15, 2011 Apr. Local Messages THIS JOURNAL IS AVAILABLE IN THE BDA LIBRARY Abstract OBJECTIVE: A variety of oral topical agents have been used for prevention and management of radiotherapy-induced adverse effects. The antimicrobial nature of some of the commonly used agents is unknown. The purpose of this study was to evaluate antimicrobial efficacies of various oral topical agents on common microorganisms associated with radiated head and neck cancer patients. METHOD AND MATERIALS: Seven commonly used topical oral agents-0.12% chlorhexidine with alcohol, 0.12% chlorhexidine without alcohol, baking soda-salt rinse, 0.4% stannous fluoride gel, 0.63% stannous fluoride rinse, calcium phosphate mouthrinse, and acemannan hydrogel (aloe vera) rinse-were evaluated in vitro for their antimicrobial efficacies against four common microorganisms. A combination of baking soda-salt rinse and 0.4% stannous fluoride gel was evaluated as the eighth agent. The microorganisms used were Staphylococcus aureus, group B Streptococcus, Escherichia coli, and Candida albicans. An ELISA reader was used to measure the turbidity of microbial culture wells and optical density (OD) values for each of the 960 wells recorded. Mean OD values were rank ordered based on their turbidity. One-way ANOVA with Tukey HSD post hoc analysis was used to study differences in OD values (P < .05). RESULTS: Mean OD values classified for topical agents from lowest to highest were chlorhexidine with alcohol, chlorhexidine without alcohol, baking soda- salt, calcium phosphate rinse, and the combination of baking soda-salt and stannous fluoride gel. Mean OD values classified for microorganisms from lowest to highest were Escherichia coli, Staphylococcus aureus, group B Streptococcus, and Candida albicans. CONCLUSION: A significant difference among the antimicrobial efficacies of topical agents was evident for each of four microorganisms (P < .05). There was also a significant difference among the antimicrobial efficacies of the same topical agent on the four microorganisms tested (P < .05). Publication Type Comparative Study. Journal Article. Date Created 20110425 Year of Publication 2011




<37> Unique Identifier 20923446 Status MEDLINE Authors Salazar-Sanchez N; Lopez-Jornet P; Camacho-Alonso F; Sanchez-Siles M. Authors Full Name Salazar-Sanchez, N; Lopez-Jornet, P; Camacho-Alonso, F; Sanchez-Siles, M. Institution Salazar-Sanchez,N. Department of Oral Medicine, Faculty of Medicine and Odontology, University of Murcia, Avda. Marques de los Velez s / n, Murcia, Spain. Title Efficacy of topical Aloe vera in patients with oral lichen planus: a randomized double-blind study. Source Journal of Oral Pathology & Medicine. 39(10):735-40, 2010 Nov. Local Messages THIS JOURNAL IS AVAILABLE IN THE BDA LIBRARY Abstract BACKGROUND: Different treatments have been used in application to symptomatic oral lichen planus (OLP), with variable results, perhaps caused by the refractory nature of the disease. The objective of this study was to evaluate the efficacy of the topical application of aloe vera (AV) in OLP compared with placebo. METHODS: A total of 64 patients with OLP were randomized in a double-blind study to either AV (32 patients) or placebo (32 patients), at a dose of 0.4 ml (70% concentration) three times a day. A Visual Analog Scale was used for rating pain, with the application of a clinical scale for scoring the lesions, the Oral Health Impact Profile 49 (OHIP-49), and the Hospital Anxiety-Depression (HAD) scale. The patients were evaluated after 6 and 12 weeks. RESULTS: No statistically significant differences were recorded between both groups in relation to pain after 6 and 12 weeks. In the AV group, complete pain remission was achieved in 31.2% of the cases after 6 weeks, and in 61% after 12 weeks. In the placebo group, these percentages were 17.2% and 41.6%, respectively. There were no adverse effects in any of the groups. In relation to quality of life, significant differences were observed between the two groups in the psychological disability domain and total OHIP-49 score. CONCLUSION: The topical application of AV improves the total quality of life score in patients with OLP.Copyright © 2010 John Wiley & Sons A/S. Publication Type Journal Article. Randomized Controlled Trial. Date Created 20101027 Year of Publication 2010

<38> Unique Identifier 20088703 Status MEDLINE Authors Jittapiromsak N; Sahawat D; Banlunara W; Sangvanich P; Thunyakitpisal P. Authors Full Name Jittapiromsak, Nawaporn; Sahawat, Dusida; Banlunara, Wijit; Sangvanich, Polkit; Thunyakitpisal, Pasutha. Institution Jittapiromsak,Nawaporn. Dental Biomaterials Science Program, Graduate School, Faculty of Dentistry, Chulalongkorn University, Bangkok, Thailand. Title Acemannan, an extracted product from Aloe vera, stimulates dental pulp cell proliferation, differentiation, mineralization, and dentin formation. Source Tissue engineering. Part A.. 16(6):1997-2006, 2010 Jun. Abstract This study investigated the effect of acemannan (Aloe vera gel polysaccharide) on dentin formation. Primary human dental pulp cells were treated with acemannan. New DNA synthesis, bone morphogenetic protein-2, alkaline phosphatase activity, dentin sialoprotein expression, and mineralization were determined by [(3)H]-thymidine incorporation, enzyme-linked immunosorbent assay, biochemical assay, western blotting, and Alizarin Red staining, respectively. Then the upper first molars of 24 male Sprague Dawley rats were intentionally exposed and capped with either acemannan or calcium hydroxide. At day 28, the teeth were histopathologically examined and evaluated for the degree of inflammation, dentin bridge formation, and pulp tissue organization. The results revealed that acemannan significantly increased pulp cell proliferation, bone morphogenetic protein-2, alkaline phosphatase activity, dentin sialoprotein expression, and mineralization, compared with the untreated group. The acemannan-treated group also exhibited a complete homogeneous calcified dentin bridge and good pulp tissue organization, whereas neither was detected in the calcium hydroxide-treated and sham groups. In the acemannan-treated group, either mild or no inflammation was found, whereas the other groups had various degrees of inflammation. The data suggest that acemannan promotes dentin formation by stimulating primary human dental pulp cell proliferation, differentiation, extracellular matrix formation, and mineralization. Acemannan also has pulpal biocompatibility and promotes soft tissue organization. Publication Type Journal Article. Research Support, Non-U.S. Gov't. Date Created 20100531 Year of Publication 2010 <39>




Unique Identifier 19819812 Status MEDLINE Authors George D; Bhat SS; Antony B. Authors Full Name George, Dilip; Bhat, Sham S; Antony, Beena. Institution George,Dilip. Department of Pedodontics and Preventive Dentistry, Pushpagiri College of Dental Sciences, Tiruvalla, Kerala, India. Title Comparative evaluation of the antimicrobial efficacy of aloe vera tooth gel and two popular commercial toothpastes: an in vitro study. Source General Dentistry. 57(3):238-41, 2009 May-Jun. Local Messages THIS JOURNAL IS AVAILABLE IN THE BDA LIBRARY Abstract Aloe vera (Aloe barbadensis Miller) has been suggested for a wide variety of ailments but its use in dentistry is limited. This article reviews the uses of the plant and describes an in vitro investigation that compared the antimicrobial effectiveness of aloe vera tooth gel with two popular, commercially available dentifrices. The preliminary results showed that aloe vera tooth gel and the toothpastes were equally effective against Candida albicans, Streptococcus mutans, Lactobacillus acidophilus, Enterococcus faecalis, Prevotella intermedia, and Peptostreptococcus anaerobius. Aloe vera tooth gel demonstrated enhanced antibacterial effect against S. mitis. Publication Type Journal Article. Date Created 20091012 Year of Publication 2009 <40> Unique Identifier 19372635 Status MEDLINE Authors Jettanacheawchankit S; Sasithanasate S; Sangvanich P; Banlunara W; Thunyakitpisal P. Authors Full Name Jettanacheawchankit, Suwimon; Sasithanasate, Siriruk; Sangvanich, Polkit; Banlunara, Wijit; Thunyakitpisal, Pasutha. Institution

Jettanacheawchankit,Suwimon. Oral Biology Program, Faculty of Dentistry, Chulalongkorn University, Bangkok, Thailand. Title Acemannan stimulates gingival fibroblast proliferation; expressions of keratinocyte growth factor-1, vascular endothelial growth factor, and type I collagen; and wound healing. Source Journal of Pharmacological Sciences. 109(4):525-31, 2009 Apr. Abstract Aloe vera has long been used as a traditional medicine for inducing wound healing. Gingival fibroblasts (GFs) play an important role in oral wound healing. In this study, we investigated the effects of acemannan, a polysaccharide extracted from Aloe vera gel, on GF proliferation; keratinocyte growth factor-1 (KGF-1), vascular endothelial growth factor (VEGF), and type I collagen production; and oral wound healing in rats. [(3)H]-Thymidine incorporation assay and ELISA were used. Punch biopsy wounds were created at the hard palate of male Sprague Dawley rats. All treatments (normal saline; 0.1% triamcinolone acetonide; plain 1% Carbopol; and Carbopol containing 0.5%, 1%, and 2% acemannan (w/w)) were applied daily. Wounded areas and histological features were observed at day 7 after treatment. From our studies, acemannan at concentrations of 2, 4, 8, and 16 mg/ml significantly induced cell proliferation (P<0.05). Acemannan concentrations between 2 - 16 mg/ml significantly stimulated KGF-1, VEGF, and type I collagen expressions (P<0.05). Wound healing of animals receiving Carbopol containing 0.5% acemannan (w/w) was significantly better than that of the other groups (P<0.05). These findings suggest that acemannan plays a significant role in the oral wound healing process via the induction of fibroblast proliferation and stimulation of KGF-1, VEGF, and type I collagen expressions. Publication Type Journal Article. Research Support, Non-U.S. Gov't. Date Created 20090417 Year of Publication 2009 <41> Unique Identifier 19089263 Status MEDLINE Authors de Oliveira SM; Torres TC; Pereira SL; Mota OM; Carlos MX. Authors Full Name de Oliveira, Silvia Morgana Araujo; Torres, Ticiana Carneiro; Pereira, Sergio Luis da Silva; Mota, Olivia Morais de Lima; Carlos, Marlio Ximenes. Institution de Oliveira,Silvia Morgana Araujo. University of Fortaleza, Ceara, Brazil. Title Effect of a dentifrice containing Aloe vera on plaque and gingivitis control. A double-blind clinical study in humans.




Source Journal of Applied Oral Science. 16(4):293-6, 2008 Jul-Aug. Other ID Source: NLM. PMC4327540 Abstract The effect of Aloe vera on the reduction of plaque and gingivitis was evaluated in a randomized, parallel and double-blind clinical trial. Subjects were randomly allocated to the test group (n=15) - dentifrice containing Aloe vera - or the control group (n=15) - fluoridated dentifrice. Plaque index (PI) and gingival bleeding index (GBI) were assessed at days 0 and 30. Subjects were asked to brush their teeth with the control or test dentifrice, three times a day, during a 30-day period. There was a significant reduction on plaque and gingivitis in both groups, but no statistically significant difference was observed among them (p>0.01). The dentifrice containing Aloe vera did not show any additional effect on plaque and gingivitis control compared to the fluoridated dentifrice. Publication Type Journal Article. Randomized Controlled Trial. Date Created 20081217 Year of Publication 2008 <42> Unique Identifier 19089263 Status MEDLINE Authors de Oliveira SM; Torres TC; Pereira SL; Mota OM; Carlos MX. Authors Full Name de Oliveira, Silvia Morgana Araujo; Torres, Ticiana Carneiro; Pereira, Sergio Luis da Silva; Mota, Olivia Morais de Lima; Carlos, Marlio Ximenes. Institution de Oliveira,Silvia Morgana Araujo. University of Fortaleza, Ceara, Brazil. Title Effect of a dentifrice containing Aloe vera on plaque and gingivitis control. A double-blind clinical study in humans. Source Journal of Applied Oral Science. 16(4):293-6, 2008 Jul-Aug. Abstract The effect of Aloe vera on the reduction of plaque and gingivitis was evaluated in a randomized, parallel and double-blind clinical trial. Subjects were randomly allocated to the test group (n=15) - dentifrice containing Aloe vera - or the control group (n=15) - fluoridated dentifrice. Plaque index (PI) and gingival bleeding index (GBI) were assessed at days 0 and 30. Subjects were asked to brush their teeth with the control or test dentifrice, three times a day, during a 30-day period. There was a significant reduction on plaque and gingivitis in both groups, but no statistically significant difference was observed among them (p>0.01). The

dentifrice containing Aloe vera did not show any additional effect on plaque and gingivitis control compared to the fluoridated dentifrice. Publication Type Journal Article. Randomized Controlled Trial. Date Created 20081217 Year of Publication 2008 <43> Unique Identifier 15779214 Status MEDLINE Authors Wynn RL. Authors Full Name Wynn, Richard L. Title Aloe vera gel: update for dentistry. [Review] [41 refs] Source General Dentistry. 53(1):6-9, 2005 Jan-Feb. Local Messages THIS JOURNAL IS AVAILABLE IN THE BDA LIBRARY Publication Type Journal Article. Review. Date Created 20050322 Year of Publication 2005 <44> Unique Identifier 12199122 Status MEDLINE Authors Watts TL. Authors Full Name Watts, T L P. Title Gloves and aloe vera. Source British Dental Journal. 193(2):62, 2002 Jul 27. Local Messages




THIS JOURNAL IS AVAILABLE IN THE BDA LIBRARY, GO TO https://www.bda.org/library/journals-articles/Documents/photocopy-request-form.pdf TO REQUEST THIS ARTICLE FROM THE LIBRARY Publication Type Letter. Date Created 20020829 Year of Publication 2002 <45> Unique Identifier 11928091 Status MEDLINE Authors Poor MR; Hall JE; Poor AS. Authors Full Name Poor, Miles R; Hall, John E; Poor, Anne S. Institution Poor,Miles R. University of Texas Southwestern Medical School, Dallas, TX, USA. [email protected] Title Reduction in the incidence of alveolar osteitis in patients treated with the SaliCept patch, containing Acemannan hydrogel. Source Journal of Oral & Maxillofacial Surgery. 60(4):374-9; discussion 379, 2002 Apr. Local Messages THIS JOURNAL IS AVAILABLE IN THE BDA LIBRARY Abstract PURPOSE: In the present study, we compared the incidence of alveolar osteitis (AO) in patients treated with either clindamycin-soaked Gelfoam (Pharmacia and Upjohn Co, Kalamazoo, MI) or SaliCept Patches (Carrington Laboratories, Inc, Irving, TX). The SaliCept Patch is a freeze-dried pledget that contains Acemannan Hydrogel (Carrington Laboratories) obtained from the clear inner gel of Aloe vera L. PATIENTS AND METHODS: A retrospective evaluation was performed of the records of 587 patients (1,031 sockets) whose extraction sites had been treated with clindamycin-soaked Gelfoam. A prospective trial was conducted in which 607 patients (1,064 sockets) had 2 SaliCept Patches placed immediately after extraction. The same surgeon treated all patients. RESULTS: Analysis restricted to mandibular third molar sites showed that 78 of 975 sites (8.0%) in the Gelfoam group developed AO, whereas only 11 of 958 sites (1.1%) in the SaliCept group developed AO (P <.0001). Further analysis of all extraction sites revealed that

the incidence of AO in the Gelfoam group was 7.6% compared with 1.1% in the SaliCept-treated group (P <.0001). CONCLUSIONS: The study results suggest that the SaliCept Patch significantly reduces the incidence of AO compared with clindamycin-soaked Gelfoam.Copyright 2002 American Association of Oral and Maxillofacial Surgeons Publication Type Clinical Trial. Comparative Study. Journal Article. Research Support, Non-U.S. Gov't. Date Created 20020402 Year of Publication 2002 <46> Unique Identifier 11915398 Status MEDLINE Authors Rieger L; Carson RE. Authors Full Name Rieger, Lisa; Carson, Robert E. Institution Rieger,Lisa. Department of Dental Hygiene, University of Oklahoma, College of Dentistry, USA. Title The clinical effects of saline and aloe vera rinses on periodontal surgical sites. Source Journal - Oklahoma Dental Association. 92(3):40-3, 2002. Publication Type Clinical Trial. Comparative Study. Journal Article. Randomized Controlled Trial. Research Support, Non-U.S. Gov't. Date Created 20020327 Year of Publication 2002 <47> Unique Identifier 11314178 Status MEDLINE Authors Moore TE. Authors Full Name Moore, T E.




Title The M and M's of aloe vera--is it for dentistry?. Source Journal - Oklahoma Dental Association. 91(3):30-1, 36, 2001. Publication Type Historical Article. Journal Article. Date Created 20010420 Year of Publication 2001 <48> Unique Identifier 10687438 Status MEDLINE Authors Hayes SM. Authors Full Name Hayes, S M. Title Lichen planus--report of successful treatment with aloe vera. Source General Dentistry. 47(3):268-72, 1999 May-Jun. Local Messages THIS JOURNAL IS AVAILABLE IN THE BDA LIBRARY Abstract Lichen planus is a disease that involves the skin and mucous membranes. It is characterized by unique eruptions. The cause of this disease is unknown, but has been linked to emotional stress, and has also been attributed to viral infections. A case is described of a successful treatment of lichen planus. Publication Type Case Reports. Journal Article. Date Created 20000301 Year of Publication 1999 <49> Unique Identifier 9830646 Status MEDLINE Authors Garnick JJ; Singh B; Winkley G. Authors Full Name

Garnick, J J; Singh, B; Winkley, G. Institution Garnick,J J. Department of Periodontics, School of Dentistry, Medical College of Georgia, Augusta, USA. Title Effectiveness of a medicament containing silicon dioxide, aloe, and allantoin on aphthous stomatitis. Source Oral Surgery Oral Medicine Oral Pathology Oral Radiology & Endodontics. 86(5):550-6, 1998 Nov. Local Messages THIS JOURNAL IS AVAILABLE IN THE BDA LIBRARY Abstract This research protocol was designed to test the effectiveness of a gel containing silicon dioxide, aloe vera, and allantoin in the healing of recurrent aphthous ulcers. The subjects were patients with histories of developing multiple ulcers on the oral mucosa during a 3-to-4-month period. The parameters used to evaluate healing were number of lesions during a 3-to-4-month period, length of the interval between ulcers, size of ulcers, and pain from ulcers. An approach was used in which data were accumulated from diaries maintained by the subjects throughout the study intervals. Because 3 active substances were present in the gel, a preliminary study (study I) was performed to indicate the effect of each active substance and each combination. In this phase, different combinations of the substances were compared with the use of the 2(3) factorial experimental design. The results of this study demonstrated that statistical differences in the durations of lesions (P = .017) were present when all 3 substances were included in the gel. In the next study (study II), which was initiated to test the results of study I, additional subjects were divided into 2 groups; one used a control gel with silicon dioxide, and the other a gel with all 3 active substances. Study II found no statistical differences in the parameters when the 2 groups were compared. In study III, a modified crossover design was used with the subjects of study II, and a significant difference was found in lesion-free intervals (P = .0335) and length of time for the study (P = .0001). The differences in lesion intervals may have been caused by the differences in study length. Alteration in the occurrence of aphthous ulcers was demonstrated by the reduction in numbers of lesions in study I and by the increase in length of intervals between lesions in study III. However, a consistent pattern was not present; this indicated a lack of effect of the gel on aphthous ulcers. Publication Type Clinical Trial. Journal Article. Randomized Controlled Trial. Research Support, Non-U.S. Gov't. Date Created 19990113 Year of Publication 1998 <50> Unique Identifier 9807143




Status MEDLINE Authors Tello CG; Ford P; Iacopino AM. Authors Full Name Tello, C G; Ford, P; Iacopino, A M. Institution Tello,C G. Department of Restorative Dentistry, Baylor College of Dentistry, Dallas, Texas 75266-0677, USA. Title In vitro evaluation of complex carbohydrate denture adhesive formulations. Source Quintessence International. 29(9):585-93, 1998 Sep. Local Messages THIS JOURNAL IS AVAILABLE IN THE BDA LIBRARY Abstract OBJECTIVE: Acemannan, a complex mannose carbohydrate derived from the aloe vera plant, has an inherent stickiness/viscosity. Prototype Acemannan denture adhesive formulations were evaluated for pH changes, cytotoxicity to human gingival fibroblasts and adhesive strength in both dry and wet conditions. METHOD AND MATERIALS: The denture adhesive formulations consisted of five combinations of Acemannan with varying concentrations of preservatives and two other formulations without preservatives. The pH of each formulation was measured over 24 hours. Assessment of cytotoxicity was accomplished using the in vitro, tetrazolium-based colorimetric assay on cultures of human gingival fibroblasts after exposure to the adhesive formulations for up to 24 hours. The adhesive strength was evaluated with a universal testing machine under initial dry conditions and after immersion in a constant-temperature water bath for up to 20 minutes. RESULTS: Formulations 1 and 2 achieved and maintained pH values above 6.0 (the critical pH for hydroxyapatite dissolution) approximately 6 hours into the study. None of the prototypes demonstrated an initial pH above the critical pH. Formulations 1, 2, 3, and 5 exhibited significant cytotoxicity to human gingival fibroblasts over 24 hours. Formulations 4, 20:1, and 150:1 demonstrated minimal cytotoxicity. Formulation 1 exhibited the poorest adhesive strength, while the most viscous formulation (prototype 150:1) was by far the best performer. Generally, adhesive bond strengths for all prototypes were quite high and relatively stable over time in a wet environment. CONCLUSION: To achieve the ideal adhesive in terms of strength, pH, and cytotoxicity, Acemannan formulation 150:1 should be adjusted to contain the preservative concentration of formulation 4 and have an initial pH value of 6.0 or higher. Publication Type Journal Article. Date Created 19981110

Year of Publication 1998 <51> Unique Identifier 6590551 Status MEDLINE Authors Sturm PG; Hayes SM. Authors Full Name Sturm, P G; Hayes, S M. Title Aloe Vera in dentistry. Source Journal of the Bergen County Dental Society. 50(8):11-4, 1984 May. Publication Type Journal Article. Date Created 19841011 Year of Publication 1984 <52> Unique Identifier 5248724 Status MEDLINE Authors Brasher WJ; Zimmermann ER; Collings CK. Authors Full Name Brasher, W J; Zimmermann, E R; Collings, C K. Title The effects of prednisolone, indomethacin, and Aloe vera gel on tissue culture cells. Source Oral Surgery, Oral Medicine, Oral Pathology. 27(1):122-8, 1969 Jan. Local Messages THIS JOURNAL IS AVAILABLE IN THE BDA LIBRARY Publication Type Comparative Study. Journal Article. Date Created 19690207 Year of Publication 1969

BDA LIBRARY MEDLINE SEARCH USE OF ALOE VERA IN … · 2015-06-12 · BDA LIBRARY MEDLINE SEARCH USE...

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