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BDA LIBRARY MEDLINE SEARCH

RECENT SYSTEMATIC REVIEWS RELATED TO PERIODONTOLOGY

Database: Ovid MEDLINE(R) and Epub Ahead of Print, In-Process & Other Non-Indexed Citations, Daily and Versions(R) <1946 to October 23, 2018> Search Strategy: -------------------------------------------------------------------------------- 1 exp *Periodontics/ or exp *Periodontal Diseases/ (65630) 2 periodont$.ti. (41632) 3 1 or 2 (77638) 4 periodontoid.tw. (61) 5 3 not 4 (77615) 6 limit 5 to english language (59360) 7 limit 6 to systematic reviews (1641) 8 review.ti. and 6 (1973) 9 7 or 8 (2790) 10 exp animals/ not humans/ (4507543) 11 9 not 10 (2760) 12 (dog or dogs or rat or rats or mice or mouse).tw. (2543583) 13 11 not 12 (2742) 14 (periodont$ or gingiv$).ti. (59998) 15 13 and 14 (1776) 16 limit 15 to yr="2018 -Current" (150) 17 remove duplicates from 16 (149) *************************** <1> Unique Identifier 30348440 Title Meta-analysis of the association between serum and gingival crevicular fluid matrix metalloproteinase-9 and periodontitis. Source Journal of the American Dental Association. 2018 Oct 19. VI 1 Status Publisher Authors Yang S; Gu B; Zhao L; Shi Q; Xu J; Wen N. Authors Full Name Yang, Shuo; Gu, Bin; Zhao, Lisheng; Shi, Quan; Xu, Juan; Wen, Ning. Local Messages THIS JOURNAL IS AVAILABLE IN THE BDA LIBRARY, BDA MEMBERS CAN ALSO ACCESS THIS JOURNAL ONLINE FROM 1995 TO DATE. Go to www.bda.org/ejournals Abstract BACKGROUND: The authors of this meta-analysis evaluated whether there is a difference in the levels of serum and gingival crevicular fluid (GCF) matrix metalloproteinase (MMP)-9 between patients with periodontitis and periodontally healthy control participants. TYPES OF STUDIES REVIEWED: The authors searched PubMed, Embase, the Cochrane Library, and the China Biology Medicine disk databases for eligible studies in which the investigators reported the relationships between MMP-9 levels in serum and GCF and periodontitis. The authors pooled the standardized mean differences (SMDs) and 95% confidence intervals (CIs) from each study to evaluate the difference in the serum and GCF MMP-9 levels between patients with periodontitis and periodontally healthy control participants. RESULTS: Results of a meta-analysis of 6 case-control studies including a total of 923 healthy control participants and 557 patients with periodontitis indicated that serum MMP-9 levels were significantly higher in patients with periodontitis than in periodontally healthy control participants (SMD, 1.60; 95% CI, 0.17 to 3.03; P < .05). Results of a separate meta-analysis of 6 case-control studies including a total of 153 healthy control participants and 189 patients with periodontitis indicated that GCF MMP-9 levels were significantly higher in patients with periodontitis than in periodontally healthy control participants (SMD, 1.96; 95% CI, 0.76 to 3.16; P < .01). CONCLUSIONS AND PRACTICAL IMPLICATIONS: The results of the meta-analysis revealed statistically significant differences in the MMP-9 levels in serum and GCF between patients with periodontitis and periodontally healthy control participants. These results cannot be used to confirm causality because the included studies were all case-control studies in which the investigators reported associations. Moreover, readers should view the results with caution because of the considerable heterogeneity among the studies included in the meta-analysis. Copyright © 2018 American Dental Association. Published by Elsevier Inc. All rights reserved. Publication Type Journal Article. Year of Publication 2018 <2> Unique Identifier 30343215 Title

Interleukin-10 polymorphisms (rs1800871, rs1800872 and rs1800896) and periodontitis risk: A meta-analysis. Source Archives of Oral Biology. 97:59-66, 2018 Oct 12. VI 1 Status Publisher Authors Yang SL; Huang SJ. Authors Full Name Yang, Shu-Liang; Huang, Shi-Jie. Institution Yang, Shu-Liang. Polyclinic Department, Affiliated Stomatology Hospital, School of Medicine, Zhejiang University, Hangzhou, China. Electronic address: [email protected]. Huang, Shi-Jie. Department of Stomatology, Central Hospital of China Railway No. 2 Engineering Group, Chengdu, China. Local Messages THIS JOURNAL IS AVAILABLE IN THE BDA LIBRARY UP TO 2014, TO REQUEST THIS ARTICLE FROM THE LIBRARY GO TO: https://www.bda.org/library/journals-articles/Documents/photocopy-request-form.pdf Abstract OBJECTIVE: The objective of this meta-analysis was to assess the association between three interleukin-10 (IL-10) promoter single nucleotide polymorphisms (rs1800871, rs1800872, and rs1800896) and periodontitis risk. METHODS: A systematic search was conducted in PubMed, Embase, and China National Knowledge Infrastructure databases and the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines were followed. RESULTS: Twenty-six studies met the inclusion criteria. The pooled analysis showed that rs1800871 was associated with an increased periodontitis risk under dominant model (CT + TT vs. CC: p = 0.004, OR = 1.79, 95% CI: 1.21-2.65) in Latin American populations but not in Asian (CT + TT vs. CC: p = 0.229, OR = 0.81, 95% CI: 0.58-1.14) and Caucasian (CT + TT vs. CC: p = 0.910, OR = 1.02, 95% CI: 0.75-1.39) populations. Similarly, rs1800872 conferred an increased risk of periodontitis only in Latin American populations (CA + AA vs. CC: p = 0.012, OR = 2.32, 95% CI: 1.20-4.47; A allele vs. C allele: p = 0.001, OR = 1.61, 95% CI: 1.22-2.14). No significant association was observed between rs1800896 and periodontitis risk. Subgrouping data according to periodontitis type revealed that rs1800872 was associated with both chronic periodontitis (A allele vs. C allele: p = 0.011, OR = 1.72, 95% CI: 1.13-2.62) and aggressive periodontitis (A allele vs. C allele: p = 0.038, OR = 1.32, 95% CI: 1.02-1.72). CONCLUSION: The studies reviewed support that the IL-10 rs1800871 and rs1800872 polymorphisms may represent a potential genetic biomarker for periodontitis risk in Latin American populations. Copyright © 2018 Elsevier Ltd. All rights reserved. Publication Type Journal Article. Year of Publication 2018 <3> Unique Identifier 30193009 Title Evaluation of periodontal ligament cell viability in different storage media based on human PDL cell culture experiments-A systematic review. [Review] Source Dental Traumatology. 2018 Sep 07. VI 1 Status Publisher Authors Osmanovic A; Halilovic S; Kurtovic-Kozaric A; Hadziabdic N. Author NameID Hadziabdic, Naida; ORCID: http://orcid.org/0000-0003-4808-703X Authors Full Name Osmanovic, Ahmed; Halilovic, Sabina; Kurtovic-Kozaric, Amina; Hadziabdic, Naida. Institution Osmanovic, Ahmed. Department of Genetics and Bioengineering, International Burch University, Sarajevo, Bosnia and Herzegovina. Halilovic, Sabina. Department of Genetics and Bioengineering, International Burch University, Sarajevo, Bosnia and Herzegovina. Kurtovic-Kozaric, Amina. Department of Genetics and Bioengineering, International Burch University, Sarajevo, Bosnia and Herzegovina. Kurtovic-Kozaric, Amina. Department of Pathology, Cytology and Human Genetics, University Clinical Center Sarajevo, Sarajevo, Bosnia and Herzegovina. Hadziabdic, Naida. Department of Oral Surgery, Faculty of Dental Medicine, University of Sarajevo, Sarajevo, Bosnia and Herzegovina. Local Messages THIS JOURNAL IS AVAILABLE IN THE BDA LIBRARY, TO REQUEST THIS ARTICLE FROM THE LIBRARY GO TO: https://www.bda.org/library/journals-articles/Documents/photocopy-request-form.pdf Abstract

BACKGROUND/AIMS: The best treatment for an avulsed tooth is immediate replantation. If this is not possible, a proper transport medium is required for the maintenance of viability of the periodontal ligament cells (PDL). The aim was to systematically review the efficacy of different storage media used for the survival of PDL cells of avulsed teeth in the in vitro setting. METHODS: The search strategy was based on the MeSH keywords in PubMed/MEDLINE: "Transport media for avulsed teeth," "Storage media for avulsed teeth," "Knocked out teeth," "Tooth avulsion," "Biological transport of avulsed tooth," "Cell survival of avulsed tooth," "Cell viability of avulsed tooth," "Tooth replantation," and "Periodontal ligament in avulsed teeth." The "AND" and "OR" Boolean operators were applied to combine keywords. Each study was evaluated for eight criteria, including use of human PDL, in vitro cell culture models, the number of passages, types of storage media, percentages of surviving PDL cells, pH and osmolality of storage media, and the type of test used to asses PDL viability. RESULTS: In 15 selected studies, nine storage media (HBSS, tap water, DMEM, milk, saliva, 10% and 20% propolis, Gatorade, and Viaspan) were analyzed at six time points. For storage up to 2 hours, HBSS, DMEM, milk, 10% propolis, 20% propolis, and Viaspan conserved more than 80% of PDL viability. For storage at 24 hours, Viaspan showed best cell survival at 88.4%, followed by DMEM (70.9%) and 10% propolis (68.3%). Milk and HBSS showed similar PDL survival at 24 hours (57.2% and 57.3%, respectively). CONCLUSIONS: Milk remains the most convenient, cheapest, and readily available solution in most situations while also being capable of keeping PDL cells alive. Further studies are required to evaluate the efficacy of more commonly found storage media besides milk. Copyright © 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. Publication Type Journal Article. Review. Year of Publication 2018 <4> Unique Identifier 30341272 Title Periodontal treatment on patients with cardiovascular disease: Systematic review and meta-analysis. Source Medicina Oral, Patologia Oral y Cirugia Bucal. 2018 Oct 20. VI 1 Status Publisher Authors Roca-Millan E; Gonzalez-Navarro B; Sabater-Recolons MM; Mari-Roig A; Jane-Salas E; Lopez-Lopez J. Authors Full Name Roca-Millan, E; Gonzalez-Navarro, B; Sabater-Recolons, M-M; Mari-Roig, A; Jane-Salas, E; Lopez-Lopez, J. Institution Roca-Millan, E. University Campus of Bellvitge Pabellon de Gobierno, 2nd floor, office 2:29 Feixa Llarga, s/n 08907- L' Hospitalet de Llobregat Barcelona, Spain [email protected]. Abstract BACKGROUND: Atherosclerotic cardiovascular disease is the main cause of mortality in developed countries. It is a chronic and systemic inflammatory disease with a multifactorial etiology. Periodontal disease is one of the many factors that contribute to its development. OBJECTIVE: To analyze the effects of periodontal treatment on cardiovascular risk parameters in patients with atherosclerotic cardiovascular disease. METHODS: A systematic research was conducted in the Pubmed/Medline databases for clinical trials published up to and including the year 2017. RESULTS: Ten articles were included for analysis. Periodontal treatment reduced C-reactive protein levels (77.8% of clinical trials), tumor necrosis factor-alpha (66.7%), interleukin-6 (100%) and leukocytes (50%). Fibrinogen levels also improved considerably (66.7%). Effects on lipid parameters were more limited, whereby only oxidized low density lipoprotein and very low density lipoprotein cholesterol decreased significantly. Meta-analysis showed a statistically significant decreased in C-reactive protein and leukocytes values when patients were submitted to non-surgical periodontal treatment in contrast to receiving no treatment at all (mean difference 1.199 mg/L, 95% confidence interval: 1.100-1.299, p<0.001; and mean difference 0,79 g/L, 95% confidence interval: 0.717-0.879, p<0.001, respectively). Publication Type Journal Article. Year of Publication 2018 <5> Unique Identifier 30327951 Title Effect of adjuvant use of metformin on periodontal treatment: a systematic review and meta-analysis. Source Clinical Oral Investigations. 2018 Oct 16. VI 1

Status Publisher Authors Nicolini AC; Grisa TA; Muniz FWMG; Rosing CK; Cavagni J. Authors Full Name Nicolini, Alessandra Cardoso; Grisa, Thaise Americo; Muniz, Francisco Wilker Mustafa Gomes; Rosing, Cassiano Kuchenbecker; Cavagni, Juliano. Institution Nicolini, Alessandra Cardoso. Department of Periodontology, Faculty of Dentistry, Federal University of Rio Grande do Sul, Rua Ramiro Barcelos, 2492, Porto Alegre, RS, 90035-003, Brazil. Grisa, Thaise Americo. Department of Periodontology, Faculty of Dentistry, Federal University of Rio Grande do Sul, Rua Ramiro Barcelos, 2492, Porto Alegre, RS, 90035-003, Brazil. Muniz, Francisco Wilker Mustafa Gomes. Department of Semiology and Clinics, Faculty of Dentistry, Federal University of Pelotas, Rua Goncalves Chaves, 457, Pelotas, RS, 96015-560, Brazil. Rosing, Cassiano Kuchenbecker. Department of Periodontology, Faculty of Dentistry, Federal University of Rio Grande do Sul, Rua Ramiro Barcelos, 2492, Porto Alegre, RS, 90035-003, Brazil. Cavagni, Juliano. Department of Periodontology, Faculty of Dentistry, Federal University of Rio Grande do Sul, Rua Ramiro Barcelos, 2492, Porto Alegre, RS, 90035-003, Brazil. [email protected]. Local Messages THIS JOURNAL IS AVAILABLE IN THE BDA LIBRARY, TO REQUEST THIS ARTICLE FROM THE LIBRARY GO TO: https://www.bda.org/library/journals-articles/Documents/photocopy-request-form.pdf Abstract OBJECTIVE: The aim of the study was to perform a systematic review of the literature regarding the adjuvant effects of metformin on the results of mechanical periodontal treatment. METHODS: First, a search on the PubMed, EMBASE, and Scopus databases was performed up to March 2018. Randomized clinical trials with at least 3 months of follow-up and using metformin associated with mechanical periodontal treatment were included in the review. As comparison group, mechanical or periodontal therapy alone or in combination with placebo. The studies should involve adults with at least 30 years of age diagnosed with chronic periodontitis. For the evaluation of the risk of bias of the articles, the Cochrane Collaboration tool was used. RESULTS: Studies (1912) were retrieved and 4 were included in the review. The articles are all from the same research center and used metformin in gel at concentrations of 0.5%, 1%, or 1.5%. The majority of included studies presented low risk of bias. A linear meta-analysis was conducted for probing depth and clinical attachment loss outcomes. The results showed a weighted mean difference of 2.12 mm (95% CI 1.83-2.42) and 2.29 mm (95% CI 1.72-2.86) for probing depth and clinical attachment level, respectively, favoring the group exposed to 1% adjunct metformin. CONCLUSION: The adjuvant use of metformin may promote an additional benefit to the results of mechanical periodontal therapy. CLINICAL SIGNIFICANCE: The metformin as an adjuvant on periodontal treatment shows potential to reduce needs of additional interventions and also reduces the inflammatory burden in patients. Publication Type Journal Article. Year of Publication 2018 <6> Unique Identifier 30189327 Title Stress, salivary cortisol and periodontitis: A systematic review and meta-analysis of observational studies. [Review] Source Archives of Oral Biology. 96:58-65, 2018 Aug 30. VI 1 Status Publisher Authors Botelho J; Machado V; Mascarenhas P; Rua J; Alves R; Cavacas MA; Delgado A; Joao Mendes J. Authors Full Name Botelho, Joao; Machado, Vanessa; Mascarenhas, Paulo; Rua, Joao; Alves, Ricardo; Cavacas, Maria Alzira; Delgado, Ana; Joao Mendes, Jose. Institution Botelho, Joao. Periodontology Department, Clinical Research Unit (CRU), Centro de Investigacao Interdisciplinar Egas Moniz (CiiEM), Instituto Universitario Egas Moniz, Campus Universitario, Monte da Caparica, 2829-511 Caparica, Portugal. Electronic address: [email protected]. Machado, Vanessa. Periodontology Department, Clinical Research Unit (CRU), Centro de Investigacao Interdisciplinar Egas Moniz (CiiEM), Instituto Universitario Egas Moniz, Campus Universitario, Monte da Caparica, 2829-511 Caparica, Portugal. Mascarenhas, Paulo. Periodontology Department, Clinical Research Unit (CRU), Centro de Investigacao Interdisciplinar Egas Moniz (CiiEM), Instituto Universitario Egas Moniz, Campus Universitario, Monte da Caparica, 2829-511 Caparica, Portugal. Rua, Joao. Clinical Research Unit (CRU), Centro de Investigacao Interdisciplinar Egas Moniz (CiiEM), Instituto Universitario Egas Moniz, Campus Universitario, Monte da Caparica, 2829-511 Caparica, Portugal. Alves, Ricardo. Periodontology Department, Clinical Research Unit (CRU), Centro de Investigacao Interdisciplinar Egas Moniz (CiiEM), Instituto Universitario Egas Moniz, Campus Universitario, Monte da Caparica, 2829-511 Caparica, Portugal.

Cavacas, Maria Alzira. Environmental Health Research Line, Centro de Investigacao Interdisciplinar Egas Moniz (CiiEM), Instituto Universitario Egas Moniz, Campus Universitario, Monte da Caparica, 2829-511 Caparica, Portugal. Delgado, Ana. Clinical Research Unit (CRU), Centro de Investigacao Interdisciplinar Egas Moniz (CiiEM), Instituto Universitario Egas Moniz, Campus Universitario, Monte da Caparica, 2829-511 Caparica, Portugal. Joao Mendes, Jose. Clinical Research Unit (CRU), Centro de Investigacao Interdisciplinar Egas Moniz (CiiEM), Instituto Universitario Egas Moniz, Campus Universitario, Monte da Caparica, 2829-511 Caparica, Portugal. Local Messages THIS JOURNAL IS AVAILABLE IN THE BDA LIBRARY UP TO 2014, TO REQUEST THIS ARTICLE FROM THE LIBRARY GO TO: https://www.bda.org/library/journals-articles/Documents/photocopy-request-form.pdf Abstract OBJECTIVE: This meta-analysis aims to systematically assess whether periodontitis has a meaningful effect on salivary cortisol, reflecting changes on free blood cortisol levels. DESIGN: The Cochrane Handbook and the PRISMA statement were used as reporting guidelines. The MEDLINE-PubMed, Google Scholar, EMBASE, and CENTRAL databases were searched until September 2017 to identify eligible studies, screened by seven independent authors and verified by an eighth. Studies comparing salivary cortisol level of periodontitis cases to controls were included. Data were extracted using a predefined table and since all papers were non-randomized clinical trials they were appraised using Downs and Black tool. DerSimonian random effects meta-analysis was performed using OpenMetaAnalyst. RESULTS: Six cross-sectional studies were included, with 258 participants with chronic periodontitis and 72 with aggressive periodontitis, in a total of 573 participants. Overall results showed that aggressive periodontitis patients have, on average, 53% higher salivary cortisol levels than healthy controls 1.53 (1.11-2.12). Meta-regression exploring the relationship among salivary cortisol levels and periodontal measures, i.e., periodontitis severity, showed a global neutral effect, although this result requires future confirmation due to the low power of the model. CONCLUSION: Observational studies results suggest that subjects with aggressive periodontitis have higher salivary cortisol levels than healthy ones or patients with chronic periodontitis. Such salivary cortisol response difference may have a negative impact on the periodontium, contributing to worse the burden of aggressive periodontitis disease. In the future, wide and well-designed longitudinal studies should be carried out in order to extensively confirm this possible effect, considering the complex nature of periodontitis and its many confounders factors that may contribute to this outcome. Copyright © 2018 Elsevier Ltd. All rights reserved. Publication Type Journal Article. Review. Year of Publication 2018 <7> Unique Identifier 30165248 Title The association between periodontitis and interleukin-6 genetic polymorphism -174 G/C: A meta-analysis. Source Archives of Oral Biology. 96:13-20, 2018 Aug 18. VI 1 Status Publisher Authors Zhao B; Li R. Authors Full Name Zhao, Bo; Li, Ronghua. Institution Zhao, Bo. Dental Department, Tianjin First Center Hospital, Tianjin, 300000, China. Li, Ronghua. Dental Department, Tianjin First Center Hospital, Tianjin, 300000, China. Electronic address: [email protected]. Local Messages THIS JOURNAL IS AVAILABLE IN THE BDA LIBRARY UP TO 2014, TO REQUEST THIS ARTICLE FROM THE LIBRARY GO TO: https://www.bda.org/library/journals-articles/Documents/photocopy-request-form.pdf Abstract BACKGROUND: To evaluate the association between periodontitis and interleukin-6 (IL6) -174 G/C polymorphism by data synthesis and subgroup analysis. METHODS: Eighteen case-control studies from 16 articles with 1616 cases and 1511 controls were included in this meta-analysis by searching the public databases including PubMed, Embase and Web of Science databases by Jun 2018. Data syntheses were performed using Stata 9.0. RESULTS: There were inverse associations of IL6 -174 G/C polymorphism with both general periodontitis and overall periodontitis. In CC vs. GG inheritance model, whose effect was the most profound, the genetic polymorphism reduced the risks of general and overall periodontitis by 60% (95% CI = 0.25-0.65, P < 0.01) and 31% (95% CI = 0.38-0.97, P = 0.04) respectively. In addition, the G/C variation was likely to be protective against moderate (allele C vs. allele G: OR = 0.61, 95% CI = 0.43-0.87, P = 0.01; CC + GC vs. GG: OR = 0.57, 95% CI = 0.37-0.89, P = 0.01) and severe periodontitis (allele C vs. allele G: OR = 0.58, 95% CI = 0.41-0.84, P < 0.01; CC vs. GG: OR = 0.33, 95% CI = 0.13-0.82, P = 0.02) exclusively in Brazilian people. No reliable evidence was found regarding chronic periodontitis.

CONCLUSION: This meta-analysis suggests that IL6 -174 G/C polymorphism may be negatively associated with risk of periodontitis. Copyright © 2018 Elsevier Ltd. All rights reserved. Publication Type Journal Article. Year of Publication 2018 <8> Unique Identifier 30306333 Title Differences in the subgingival microbial population of chronic periodontitis in subjects with and without type 2 diabetes mellitus-a systematic review. [Review] Source Clinical Oral Investigations. 2018 Oct 10. VI 1 Status Publisher Authors Liu LS; Gkranias N; Farias B; Spratt D; Donos N. Author NameID Gkranias, Nikolaos; ORCID: http://orcid.org/0000-0001-8686-5424 Authors Full Name Liu, Linda Sun; Gkranias, Nikolaos; Farias, Bruna; Spratt, Dave; Donos, Nikolaos. Institution Liu, Linda Sun. Periodontology Unit, UCL Eastman Dental Institute, London, UK. Gkranias, Nikolaos. Centre for Oral Clinical Research, Institute of Dentistry, Barts & The London School of Medicine & Dentistry, Queen Mary University of London (QMUL), Turner Street, London, UK. Farias, Bruna. Postgraduate Department, Federal University of Pernambuco, Recife, Brazil. Spratt, Dave. Microbiology Department, UCL Eastman Dental Institute, London, UK. Donos, Nikolaos. Centre for Oral Clinical Research, Institute of Dentistry, Barts & The London School of Medicine & Dentistry, Queen Mary University of London (QMUL), Turner Street, London, UK. [email protected]. Local Messages THIS JOURNAL IS AVAILABLE IN THE BDA LIBRARY, TO REQUEST THIS ARTICLE FROM THE LIBRARY GO TO: https://www.bda.org/library/journals-articles/Documents/photocopy-request-form.pdf Abstract OBJECTIVES: The purpose of this systematic review was to evaluate the available evidence in the literature in regard to the subgingival microbial population of chronic periodontitis in subjects with type 2 diabetes mellitus (T2DM+PD) compared to non-diabetic subjects (NDM+PD). MATERIALS AND METHODS: A literature search was conducted at Ovid MEDLINE and EMBASE database from 1980 to 2016, supplemented by hand searching as needed. Studies presenting with at least one of the primary outcomes (presence of any subgingival microorganisms, proportion and/or the amount of any subgingival plaque bacteria in T2DM+PD versus NDM+PD) were included. Screening, data extraction and quality assessment were conducted independently and in duplicate. RESULTS: From 611 citations, 19 full-text papers were screened and 11 articles were included for critical appraisal by both reviewers. Some evidence of a difference in the microbial profile between chronic PD subjects with and without T2DM was identified. The strength of evidence is strongest in Tannerella forthysia (T .forsythia) which was reported to be less frequent in the diabetic (T2DM+PD) group in five of the studies, followed by a weaker strength of evidence for other periodontal pathogens such as Porphyromonas gingivalis (P. gingivalis) and Aggregatibacter actinomycetemcomitans (A. actinomycetemcomitans), which were also found less frequent in the diabetic (T2DM+PD) group . CONCLUSION: Only few studies have compared T2DM+PD with NDM+PD. It is therefore strongly recommended that further studies which include four distinct groups of participants (NDM+PD, T2DM+PD, NDM+NPD, T2DM+NPD) instead of using intra-subject comparisons between healthy and diseased sites of the same subjects. CLINICAL RELEVANCE: Differences in bacterial populations of T2DM+PD in comparison to NDM+PD subjects may indicate the need of different protocols for the treatment of the diabetic patients with periodontal disease. Publication Type Journal Article. Review. Year of Publication 2018 <9> Unique Identifier 30230662 Title Specialized pro-resolving lipid mediators in experimental periodontitis: A systematic review. [Review] Source Oral Diseases. 2018 Sep 19. VI 1 Status Publisher

Authors Osorio Parra MM; Elangovan S; Lee CT. Author NameID Lee, Chun-Teh; ORCID: http://orcid.org/0000-0001-7812-5637 Authors Full Name Osorio Parra, Marcela M; Elangovan, Satheesh; Lee, Chun-Teh. Institution Osorio Parra, Marcela M. Department of Periodontics, The University of Iowa College of Dentistry, Iowa City, Iowa. Elangovan, Satheesh. Department of Periodontics, The University of Iowa College of Dentistry, Iowa City, Iowa. Lee, Chun-Teh. Department of Periodontics and Dental Hygiene, The University of Texas Health Science Center at Houston, Houston, Texas. Local Messages THIS JOURNAL IS AVAILABLE IN THE BDA LIBRARY, TO REQUEST THIS ARTICLE FROM THE LIBRARY GO TO: https://www.bda.org/library/journals-articles/Documents/photocopy-request-form.pdf Abstract Recently, several studies demonstrated the potential of using specialized pro-resolving lipid mediators (SPMs), as a novel approach, in treating periodontitis in pre-clinical models. This review aimed to systematically evaluate the biological actions of SPMs on periodontal tissues in animals with experimentally induced periodontitis. This systematic review was performed by following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Studies were searched in three databases. Meta-analysis was not performed because of the data heterogeneity. Study quality was assessed using Systematic Review Centre for Laboratory Animal Experimentation (SYRCLE) Risk of Bias tool. Six studies using an experimental periodontitis model to test the efficacy of SPMs were selected. Resolvin E1 and lipoxins were topically applied to treat experimental periodontitis. Alveolar bone loss could be significantly prevented and regenerated by applying SPMs, when compared to the control group. The dosages of SPMs and the periods of disease induction varied based on the pre-clinical model employed. Two studies further demonstrated the positive shift in microbial composition, in line with positive shift in inflammatory status, that are regulated by SPMs. Clinical studies are needed to optimize the application of SPMs in treating periodontal diseases in humans. Copyright © 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. All rights reserved. Publication Type Journal Article. Review. Year of Publication 2018 <10> Unique Identifier 30295312 Title Interleukin-10 gene polymorphisms and chronic periodontitis susceptibility: Evidence based on 33 studies. [Review] Source Journal of Periodontal Research. 2018 Oct 08. VI 1 Status Publisher Authors Zhang Z; Zheng Y; Li X. Author NameID Li, Xinyue; ORCID: http://orcid.org/0000-0002-0360-637X Authors Full Name Zhang, Zheng; Zheng, Youli; Li, Xinyue. Institution Zhang, Zheng. Department of Periodontology, Tianjin Stomatological Hospital, Nankai University, Tianjin, China. Zheng, Youli. Department of General Dentistry, Stomatological Hospital, Tianjin Medical University, Tianjin, China. Li, Xinyue. Department of Periodontology, Tianjin Stomatological Hospital, Nankai University, Tianjin, China. Local Messages THIS JOURNAL IS AVAILABLE IN THE BDA LIBRARY, TO REQUEST THIS ARTICLE FROM THE LIBRARY GO TO: https://www.bda.org/library/journals-articles/Documents/photocopy-request-form.pdf Abstract The purpose of the meta-analysis was to investigate the potential association of interleukin-10 (IL-10) polymorphisms with susceptibility to chronic periodontitis (CP). A total of 33 studies involving 3487 cases and 4356 controls were identified through a search of multiple electronic databases (last search was updated on 19 July 2018). Three single nucleotide polymorphisms (SNPs) were included in the meta-analysis: -1082A>G(rs1800896), -819C>T(rs1800871), and -592C>A(rs1800872). Odds ratios (ORs) and their 95% confidence intervals (CIs) using allele, dominant, and recessive genetic models were computed to assess the strength of the association. The -1082A>G(rs1800896) polymorphism was found to be associated with decreased CP risk in both Caucasians and Latinos under the dominant model. The -819C>T(rs1800871) and -592C>A(rs1800872) polymorphisms were both associated with increased CP risk in Latinos under the allele and dominant models. In Asians, no associations were observed for any of the polymorphisms under all comparison models. The present meta-analysis suggests that the -1082A>G(rs1800896) polymorphism might be a protective factor for CP in both Caucasians and Latinos, but the -819C>T(rs1800871) and -592C>A(rs1800872) polymorphisms might contribute to CP pathogenesis in Latinos. Copyright © 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. Publication Type Journal Article. Review. Year of Publication 2018

<11> Unique Identifier 30260723 Title Lasers in non-surgical periodontal treatment - a review. Source Journal of Cosmetic & Laser Therapy. 1-7, 2018 Sep 27. VI 1 Status Publisher Authors Sumra N; Kulshrestha R; Umale V; Chandurkar K. Author NameID Kulshrestha, Rohit; ORCID: http://orcid.org/0000-0002-8133-7515 Authors Full Name Sumra, Nida; Kulshrestha, Rohit; Umale, Vinay; Chandurkar, Kshama. Institution Sumra, Nida. a Consulting Periodontist, Private Practice , Mumbai , India. Kulshrestha, Rohit. b Consulting Orthodontist , Private Practice , Mumbai , India. Umale, Vinay. c Senior Lecturer , Department of Orthodontics , Yogita Dental College , Khed Maharashtra , India. Chandurkar, Kshama. d Senior Lecturer , Yogita Dental College , Khed Maharashtra , India. Abstract AIM: Aim of this review was to present a comprehensive outline of the use of hard tissue lasers in Periodontics with respect to non-surgical periodontal treatment. MATERIALS AND METHOD: Electronic databases of PubMed and Cochrane Library were searched from 1992 to 2018. 18 clinical studies were evaluated after the inclusion, exclusion criteria. RESULTS: It was deduced that Er:YAG laser is a feasible option for non-surgical periodontal therapy if proper parameters are followed i.e. the energy in the range of 140-160 mJ and frequency of 10 Hz. None of the studies favoured the use of Nd:YAG and CO2 laser because of their prospective adverse effects. CONCLUSION: It can be concluded that Er:YAG laser application in non-surgical periodontal therapy is valuable. In combination with mechanical debridement, the results are similar or better with significant gains in clinical attachment level as compared to other various lasers. It is an excellent alternative to control the proliferation of micro-organisms. Nd:YAP, diode and other low power lasers can be used but with caution since they offer no additional advantage over conventional treatment modalities. Publication Type Journal Article. Year of Publication 2018 <12> Unique Identifier 30145192 Title Periodontal Regenerative Therapy for Preventing Bone Defects Distal to Mandibular Second Molars After Surgical Removal of Impacted Third Molars: A Systematic Review and Meta-Analysis of Randomized Clinical Trials. [Review] Source Journal of Oral & Maxillofacial Surgery. 2018 Jul 30. VI 1 Status Publisher Authors Camps-Font O; Caro-Bonfill C; Sanchez-Garces MA; Gay-Escoda C. Authors Full Name Camps-Font, Octavi; Caro-Bonfill, Cristina; Sanchez-Garces, Maria Angels; Gay-Escoda, Cosme. Institution Camps-Font, Octavi. Master of Oral Surgery and Implantology, Associate Professor of Oral Surgery, and Professor of Master's Degree Program in Oral Surgery and Implantology, Faculty of Medicine and Health Sciences, University of Barcelona, Barcelona, Spain. Electronic address: [email protected]. Caro-Bonfill, Cristina. Dentist, Faculty of Medicine and Health Sciences, University of Barcelona, Barcelona, Spain. Sanchez-Garces, Maria Angels. Master of Oral Surgery and Implantology, Associate Professor of Oral Surgery, and Professor of Master's Degree Program in Oral Surgery and Implantology, Faculty of Medicine and Health Sciences, University of Barcelona, Barcelona, Spain; and Researcher, Bellvitge Biomedical Research Institute, Barcelona, Spain. Gay-Escoda, Cosme. Chairman and Professor of Oral and Maxillofacial Surgery, Faculty of Medicine and Health Sciences, University of Barcelona, Barcelona, Spain; Director of Master's Degree Program in Oral Surgery and Implantology, European Foundation for Health Research and Education International University, Belize City, Belize and Private Catalan Foundation for Oral Health, Barcelona, Spain; Coordinator/Researcher, Bellvitge Biomedical Research Institute, Barcelona, Spain; and Head of Oral Surgery, Implantology and Maxillofacial Surgery Department, Teknon Medical Center, Barcelona, Spain. Local Messages THIS JOURNAL IS AVAILABLE IN THE BDA LIBRARY, BDA MEMBERS CAN ALSO ACCESS THIS JOURNAL ONLINE FROM 2011 TO DATE. Go to www.bda.org/ejournals Abstract

PURPOSE: The purpose of this study was to assess which regenerative techniques are most effective for preventing periodontal defects after extraction of the third molars, as well as to compare these procedures with spontaneous healing of the socket. MATERIALS AND METHODS: Five electronic databases were searched to identify randomized clinical trials that fulfilled the eligibility criteria. Two independent reviewers conducted literature screening, article selection, and data extraction. The outcome measures were mean clinical attachment level (CAL) gain, mean probing depth (PD) reduction, mean alveolar bone level (ABL) gain, and adverse events. The influence of several variables of interest on the outcomes of periodontal regenerative therapy was explored via subgroup analyses. RESULTS: Among 1,205 potentially eligible articles, 21 randomized clinical trials were included. Eighteen trials assessed periodontal regenerative therapy as an alternative to extraction alone. Statistically significant differences were found in CAL gain (1.98 mm; 95% confidence interval [CI], 1.44 to 2.52 mm; P < .001), PD reduction (1.76 mm; 95% CI, 1.20 to 2.31 mm; P < .001), and ABL gain (1.21 mm; 95% CI, 0.21 to 2.21 mm; P = .018). The risk of complications developing at treated sites did not increase with the regenerative procedures (odds ratio, 1.49; 95% CI, 0.71 to 3.14; P = .290). There was no evidence of any regenerative procedure being better than any other. However, osseous grafting techniques were associated with a significantly higher adverse event rate. CONCLUSIONS: Regenerative periodontal therapy, in comparison with spontaneous healing of the wound, is more effective regarding initial improvement in CAL gain, PD reduction, and ABL gain, without increasing the risk of postoperative complications. Copyright © 2018 American Association of Oral and Maxillofacial Surgeons. Published by Elsevier Inc. All rights reserved. Publication Type Journal Article. Review. Year of Publication 2018 <13> Unique Identifier 30220644 Title Comment on: Relationship between bariatric surgery and periodontal status: a systematic review and meta-analysis. Source Surgery for Obesity & Related Diseases. 2018 Aug 08. VI 1 Status Publisher Authors Sanguankeo A; Upala S. Authors Full Name Sanguankeo, Anawin; Upala, Sikarin. Institution Sanguankeo, Anawin. Division of Nephrology, Johns Hopkins University School of Medicine, Baltimore, MD, USA. Upala, Sikarin. Department of Preventive and Social Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand. Publication Type Editorial. Year of Publication 2018 <14> Unique Identifier 30218097 Title Meta-analysis of genome-wide association studies of aggressive and chronic periodontitis identifies two novel risk loci. Source European Journal of Human Genetics. 2018 Sep 14. VI 1 Status Publisher Authors Munz M; Richter GM; Loos BG; Jepsen S; Divaris K; Offenbacher S; Teumer A; Holtfreter B; Kocher T; Bruckmann C; Jockel-Schneider Y; Graetz C; Ahmad I; Staufenbiel I; van der Velde N; Uitterlinden AG; de Groot LCPGM; Wellmann J; Berger K; Krone B; Hoffmann P; Laudes M; Lieb W; Franke A; Erdmann J; Dommisch H; Schaefer AS. Author NameID Munz, Matthias; ORCID: http://orcid.org/0000-0002-4728-3357 Divaris, Kimon; ORCID: http://orcid.org/0000-0003-1290-7251 Teumer, Alexander; ORCID: http://orcid.org/0000-0002-8309-094X de Groot, Lisette C P G M; ORCID: http://orcid.org/0000-0003-2778-2789 Franke, Andre; ORCID: http://orcid.org/0000-0003-1530-5811 Schaefer, Arne S; ORCID: http://orcid.org/0000-0001-5816-6765 Authors Full Name Munz, Matthias; Richter, Gesa M; Loos, Bruno G; Jepsen, Soren; Divaris, Kimon; Offenbacher, Steven; Teumer, Alexander; Holtfreter, Birte; Kocher, Thomas; Bruckmann, Corinna; Jockel-Schneider, Yvonne; Graetz, Christian; Ahmad, Ilyas; Staufenbiel, Ingmar; van der Velde, Nathalie; Uitterlinden, Andre G; de Groot, Lisette C P G M; Wellmann, Jurgen; Berger, Klaus; Krone,

Bastian; Hoffmann, Per; Laudes, Matthias; Lieb, Wolfgang; Franke, Andre; Erdmann, Jeanette; Dommisch, Henrik; Schaefer, Arne S. Institution Munz, Matthias. Department of Periodontology and Synoptic Dentistry, Institute of Health, Institute for Dental and Craniofacial Sciences, Charite-University Medicine Berlin, corporate member of Freie Universitat Berlin, Humboldt-Universitat zu Berlin, Berlin, Germany. Munz, Matthias. Institute for Cardiogenetics, University of Lubeck, 23562, Lubeck, Germany. Richter, Gesa M. Department of Periodontology and Synoptic Dentistry, Institute of Health, Institute for Dental and Craniofacial Sciences, Charite-University Medicine Berlin, corporate member of Freie Universitat Berlin, Humboldt-Universitat zu Berlin, Berlin, Germany. Loos, Bruno G. Department of Periodontology and Oral Biochemistry, Academic Centre for Dentistry Amsterdam (ACTA), University of Amsterdam and Vrije Universiteit Amsterdam, Amsterdam, The Netherlands. Jepsen, Soren. Department of Periodontology, Operative and Preventive Dentistry, University of Bonn, Bonn, Germany. Divaris, Kimon. Department of Pediatric Dentistry, School of Dentistry, University of North Carolina at Chapel Hill, Chapel Hill, USA. Divaris, Kimon. Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, USA. Offenbacher, Steven. Department of Periodontology, School of Dentistry, University of North Carolina at Chapel Hill, Chapel Hill, USA. Teumer, Alexander. Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany. Holtfreter, Birte. Unit of Periodontology, Department of Restorative Dentistry, Periodontology, Endodontology, Preventive Dentistry and Pedodontics, Dental School, University Medicine Greifswald, Greifswald, Germany. Kocher, Thomas. Unit of Periodontology, Department of Restorative Dentistry, Periodontology, Endodontology, Preventive Dentistry and Pedodontics, Dental School, University Medicine Greifswald, Greifswald, Germany. Bruckmann, Corinna. Department of Conservative Dentistry and Periodontology, Medical University Vienna, School of Dentistry, Vienna, Austria. Jockel-Schneider, Yvonne. Department of Periodontology, Clinic of Preventive Dentistry and Periodontology, University Medical Center of the Julius-Maximilians-University, Wurzburg, Germany. Graetz, Christian. Unit of Periodontology, Department of Conservative Dentistry, University Medical Center Schleswig-Holstein, Campus Kiel, Germany. Ahmad, Ilyas. Institute for Cardiogenetics, University of Lubeck, 23562, Lubeck, Germany. Staufenbiel, Ingmar. Department of Conservative Dentistry, Periodontology and Preventive Dentistry, Hannover Medical School, Hannover, Germany. van der Velde, Nathalie. Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands. van der Velde, Nathalie. Department of Internal Medicine section of Geriatrics, Amsterdam Medical Center, Amsterdam, The Netherlands. Uitterlinden, Andre G. Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands. de Groot, Lisette C P G M. Wageningen University, Division of Human Nutrition, Wageningen, The Netherlands. Wellmann, Jurgen. Institute of Epidemiology and Social Medicine, University Munster, Munster, Germany. Berger, Klaus. Institute of Epidemiology and Social Medicine, University Munster, Munster, Germany. Krone, Bastian. Institute of Medical Informatics, Biometry and Epidemiology, University Clinic Essen, Essen, Germany. Hoffmann, Per. Institute of Human Genetics, University of Bonn, Bonn, Germany. Hoffmann, Per. Human Genomics Research Group, Department of Biomedicine, University Hospital of Basel, Basel, Switzerland. Laudes, Matthias. Department of Medicine 1, University of Kiel, Kiel, Germany. Lieb, Wolfgang. Institute of Epidemiology, Christian-Albrechts-University, Kiel, Germany. Franke, Andre. Institute of Epidemiology, Christian-Albrechts-University, Kiel, Germany. Erdmann, Jeanette. Institute for Cardiogenetics, University of Lubeck, 23562, Lubeck, Germany. Erdmann, Jeanette. DZHK (German Research Centre for Cardiovascular Research) partner site Hamburg/Lubeck/Kiel, 23562, Lubeck, Germany. Erdmann, Jeanette. University Heart Center Luebeck, 23562, Lubeck, Germany. Dommisch, Henrik. Department of Periodontology and Synoptic Dentistry, Institute of Health, Institute for Dental and Craniofacial Sciences, Charite-University Medicine Berlin, corporate member of Freie Universitat Berlin, Humboldt-Universitat zu Berlin, Berlin, Germany. Schaefer, Arne S. Department of Periodontology and Synoptic Dentistry, Institute of Health, Institute for Dental and Craniofacial Sciences, Charite-University Medicine Berlin, corporate member of Freie Universitat Berlin, Humboldt-Universitat zu Berlin, Berlin, Germany. [email protected]. Abstract Periodontitis is one of the most common inflammatory diseases, with a prevalence of 11% worldwide for the severe forms and an estimated heritability of 50%. It is classified into the widespread moderate form chronic periodontitis (CP) and the rare early-onset and severe phenotype aggressive periodontitis (AgP). These different disease manifestations are thought to share risk alleles and predisposing environmental factors. To obtain novel insights into the shared genetic etiology and the underlying molecular mechanisms of both forms, we performed a two step-wise meta-analysis approach using genome-wide association studies of both phenotypes. Genotypes from imputed genome-wide association studies (GWAS) of AgP and CP comprising 5,095 cases and 9,908 controls of North-West European genetic background were included. Two loci were associated with periodontitis at a genome-wide significance level. They located within the pseudogene MTND1P5 on chromosome 8 (rs16870060-G, P = 3.69 x 10-9, OR = 1.36, 95% CI = [1.23-1.51]) and intronic of the long intergenic non-coding RNA LOC107984137 on chromosome 16, downstream of the gene SHISA9 (rs729876-T, P = 9.77 x 10-9, OR = 1.24, 95% CI = [1.15-1.34]). This study identified novel risk loci of periodontitis, adding to the genetic basis of AgP and CP. Publication Type Journal Article. Year of Publication 2018 <15>

Unique Identifier 30207437 Title Periodontitis and the microbiome: a systematic review and meta-analysis. Source Minerva Stomatologica. 2018 Sep 10. VI 1 Status Publisher Authors Guerra F; Mazur M; Ndokaj A; Corridore D; La Torre G; Polimeni A; Ottolenghi L. Authors Full Name Guerra, Fabrizio; Mazur, Marta; Ndokaj, Artnora; Corridore, Denise; La Torre, Giuseppe; Polimeni, Antonella; Ottolenghi, Livia. Institution Guerra, Fabrizio. Department of Oral and Maxillofacial Sciences, Sapienza University of Rome, Rome, Italy. Mazur, Marta. Department of Oral and Maxillofacial Sciences, Sapienza University of Rome, Rome, Italy - [email protected]. Ndokaj, Artnora. Department of Oral and Maxillofacial Sciences, Sapienza University of Rome, Rome, Italy. Corridore, Denise. Department of Oral and Maxillofacial Sciences, Sapienza University of Rome, Rome, Italy. La Torre, Giuseppe. Department of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy. Polimeni, Antonella. Department of Oral and Maxillofacial Sciences, Sapienza University of Rome, Rome, Italy. Ottolenghi, Livia. Department of Oral and Maxillofacial Sciences, Sapienza University of Rome, Rome, Italy. Local Messages *SOME ISSUES AVAILABLE IN BDA LIBRARY - PLEASE ASK Abstract INTRODUCTION: The association between the oral microbiome and periodontal diseases is still unclear. We performed a systematic review and meta-analysis to quantify the association between the specific pathogens and periodontitis. EVIDENCE ACQUISITION: A computerized medical search was performed using MEDLINE and SCOPUS database between 1950 and May 2017 to identify all case-control studies that evaluated the association between specific pathogens and periodontitis. The pooled Odds Ratio with relative 95% confidence interval (95% CI) was calculated and plotted in the forest plot. EVIDENCE SYNTHESIS: 11 RCTs involving 2111 patients were included. The retrieved case-control studies evaluated the presence or absence of different targeted pathogens. Among the microrganisms evaluated Porphyromonas gengivalis [OR (95% CI) 2.93(0.98,8.87); P< 0.0001] and Streptococcus mutans [OR (95% CI) 1.77 (0.89-3.54); P=0.03] were found to be risk factors for the development of periodontitis, while Aggregatibacter actinomycetemcomitans [OR (95% CI) 0.52 (0.33-0.83)] played a protective role for periodontitis. CONCLUSIONS: It seems that changes in the taxonomic composition of the microbiome rather than single targeted pathogens is the key determinant of periodontitis. Publication Type Journal Article. Year of Publication 2018 <16> Unique Identifier 30199601 Title Sol-gel bioglasses in dental and periodontal regeneration: A systematic review. [Review] Source Journal of Biomedical Materials Research. Part B, Applied Biomaterials. 2018 Sep 10. VI 1 Status Publisher Authors Farano V; Maurin JC; Attik N; Jackson P; Grosgogeat B; Gritsch K. Authors Full Name Farano, Vincenzo; Maurin, Jean-Christophe; Attik, Nina; Jackson, Phil; Grosgogeat, Brigitte; Gritsch, Kerstin. Institution Farano, Vincenzo. Universite Lyon, Universite Claude Bernard Lyon 1, CNRS, Laboratoire des Multimateriaux et Interfaces, Villeurbanne, France. Farano, Vincenzo. Faculte d'Odontologie, Universite Claude Bernard Lyon 1, Lyon, France. Maurin, Jean-Christophe. Universite Lyon, Universite Claude Bernard Lyon 1, CNRS, Laboratoire des Multimateriaux et Interfaces, Villeurbanne, France. Maurin, Jean-Christophe. Faculte d'Odontologie, Universite Claude Bernard Lyon 1, Lyon, France. Maurin, Jean-Christophe. Service d'Odontologie, Hospices Civils de Lyon, Lyon, France. Attik, Nina. Universite Lyon, Universite Claude Bernard Lyon 1, CNRS, Laboratoire des Multimateriaux et Interfaces, Villeurbanne, France. Attik, Nina. Faculte d'Odontologie, Universite Claude Bernard Lyon 1, Lyon, France. Jackson, Phil. Lucideon Limited, Queens Road, Penkhull, Stoke-on-Trent, Staffordshire, ST4 7LQ, UK. Grosgogeat, Brigitte. Universite Lyon, Universite Claude Bernard Lyon 1, CNRS, Laboratoire des Multimateriaux et Interfaces, Villeurbanne, France. Grosgogeat, Brigitte. Faculte d'Odontologie, Universite Claude Bernard Lyon 1, Lyon, France. Grosgogeat, Brigitte. Service d'Odontologie, Hospices Civils de Lyon, Lyon, France.

Gritsch, Kerstin. Universite Lyon, Universite Claude Bernard Lyon 1, CNRS, Laboratoire des Multimateriaux et Interfaces, Villeurbanne, France. Gritsch, Kerstin. Faculte d'Odontologie, Universite Claude Bernard Lyon 1, Lyon, France. Gritsch, Kerstin. Service d'Odontologie, Hospices Civils de Lyon, Lyon, France. Abstract Due to their osteoconductive and osteoinductive abilities, bioglasses (BGs) have attracted attention in tissue engineering, especially for mineralized tissue. The aim of this study is to review the current state of the art on the effects of BGs produced by sol-gel on cells for dental and periodontal regeneration. The study also discusses associated antibacterial properties. The research was performed by considering the Preferred Reporting Items for Systematic Reviews and the Meta-Analyses (PRISMA) statement. The research ranged 5 years' window time (from January, 01, 2012, to August, 31, 2017) and the relevant studies were identified based on the inclusion/exclusion criteria. A total of 45 articles were selected from 244 initial returns, plus seven further articles coming from other sources were selected for the same purpose. From this systematic study, it is revealed that only 13 of the 52 articles have proved both the ability of BGs to differentiate dental cells at genetic level and their ability of triggering cell-mediated mineralization, but only six of them showed, along with cells, the antibacterial properties of the glasses. This review shows that sol-gel BGs are not toxic, can sustain cell proliferation and differentiation at a genetic level, and can keep the bacterial population under control. Moreover, a standard methodology and an ideal material are suggested. © 2018 Wiley Periodicals, Inc. J. Biomed. Mater. Res. Part B, 2018. Copyright © 2018 Wiley Periodicals, Inc. Publication Type Journal Article. Review. Year of Publication 2018 <17> Unique Identifier 30198204 Title Efficacy of adjunctive low-level laser therapy in the treatment of aggressive periodontitis: A systematic review. [Review] Source Journal of Investigative & Clinical Dentistry. e12361, 2018 Sep 09. VI 1 Status Publisher Authors Mokeem S. Author NameID Mokeem, Sameer; ORCID: http://orcid.org/0000-0002-6921-0132 Authors Full Name Mokeem, Sameer. Institution Mokeem, Sameer. Department of Periodontics and Community Dentistry, King Saud University, Riyadh, Saudi Arabia. Abstract The aim of the present study was to systematically review the efficacy of low-level laser therapy (LLLT) as an adjunct to scaling and root planing (SRP) vs SRP alone in the treatment of aggressive periodontitis (AgP). The addressed PICO (Population, Interventions, Comparisons and Outcomes) question was: Is LLLT as an adjunct to SRP effective in the treatment of AgP? Electronic databases, including MEDLINE via PubMed, Cochrane Central Register of Controlled Trials and Cochrane Oral Health Group Trials, and EMBASE, were searched until March 2018. Four clinical studies were included. Three studies showed significant improvement in periodontal outcomes among LLLT group compared to SRP alone, whereas only one study showed comparable periodontal outcomes between the adjunctive LLLT and SRP groups at follow up. The overall mean difference for clinical attachment level gain (weighted mean difference [WMD] = -1.69, 95% confidence interval [CI] = -3.46 to 0.07, P < 0.061) was not significant. However, significant difference for probing depth reduction (WMD = -0.95, 95% CI = -1.66 to 0.23, P = 0.009) was noticed between groups at follow up. Whether LLLT as an adjunct to SRP is more effective than SRP alone in the treatment of AgP remains debatable. Further randomized, clinical trials are required with long follow-up periods and standard laser parameters to reach a strong conclusion. Copyright © 2018 John Wiley & Sons Australia, Ltd. Publication Type Journal Article. Review. Year of Publication 2018 <18> Unique Identifier 30154031 Title Bariatric surgery and periodontal status: A systematic review with meta-analysis. Source Surgery for Obesity & Related Diseases. 2018 Jul 24. VI 1 Status Publisher Authors Fontanille I; Boillot A; Range H; Carra MC; Sales-Peres SHC; Czernichow S; Bouchard P. Authors Full Name

Fontanille, Isabelle; Boillot, Adrien; Range, Helene; Carra, Maria Clotilde; Sales-Peres, Silvia Helena de Carvalho; Czernichow, Sebastien; Bouchard, Philippe. Institution Fontanille, Isabelle. Department of Periodontology, Service of Odontology, Rothschild Hospital, AP-HP, Paris 7-Denis Diderot University, U.F.R. of Odontology, Paris, France. Boillot, Adrien. Department of Periodontology, Service of Odontology, Rothschild Hospital, AP-HP, Paris 7-Denis Diderot University, U.F.R. of Odontology, Paris, France. Range, Helene. Department of Periodontology, Service of Odontology, Rothschild Hospital, AP-HP, Paris 7-Denis Diderot University, U.F.R. of Odontology, Paris, France; EA 2496, Paris 5-Descartes University, U.F.R. of Odontology, Paris, France. Carra, Maria Clotilde. Department of Periodontology, Service of Odontology, Rothschild Hospital, AP-HP, Paris 7-Denis Diderot University, U.F.R. of Odontology, Paris, France. Sales-Peres, Silvia Helena de Carvalho. Department of Pediatric Dentistry, Orthodontics and Public Health, Bauru School of Dentistry, University of Sao Paulo, Sao Paulo, Brazil. Czernichow, Sebastien. Department of Nutrition, Hopital Europeen Georges-Pompidou, Paris Descartes University, Assistance Publique-Hopitaux de Paris (AP-HP), Paris, France. Bouchard, Philippe. Department of Periodontology, Service of Odontology, Rothschild Hospital, AP-HP, Paris 7-Denis Diderot University, U.F.R. of Odontology, Paris, France; EA 2496, Paris 5-Descartes University, U.F.R. of Odontology, Paris, France. Electronic address: [email protected]. Abstract OBJECTIVE: To review and analyze periodontal clinical parameters after bariatric surgery. BACKGROUND: Periodontitis, a dysbiotic inflammatory disease, has been associated with obesity. The purpose of bariatric surgery is to reduce weight and systemic inflammation. Consequently, it is of interest to systematically review the impact of bariatric surgery on periodontal status. METHODS: Electronic searches were conducted in MEDLINE, EMBASE, Thesis database, and the Cochrane Library databases. Gray literature and the main journals of both specialties were also reviewed. Only cross-sectional and prospective studies focusing on bleeding on probing, pocket depth, and clinical attachment levels were selected. RESULTS: After a thorough screening of 651 studies, 10 studies were selected by 2 independent reviewers. Four (n=250) and 3 studies (n=191) were included in the meta-analysis at 6- and 12-month follow-up, respectively. At 6-month follow-up increased periodontal inflammation (P=.03) and periodontal destruction were observed. However, 12 months after baseline, the difference between bariatric patients and control was no longer significant. CONCLUSION: The present systematic review and meta-analysis suggests that deterioration of periodontal status may be observed in the first 6 months after surgery. Consequently, periodontal screening and management of the patient's request for bariatric surgery should be recommended to avoid further deterioration of periodontal status after bariatric surgery. Copyright © 2018 American Society for Bariatric Surgery. Published by Elsevier Inc. All rights reserved. Publication Type Journal Article. Year of Publication 2018 <19> Unique Identifier 29934798 Title Clinical periodontal variables in patients with and without dementia-a systematic review and meta-analysis. [Review] Source Clinical Oral Investigations. 2018 Jun 22. VI 1 Status Publisher Authors Maldonado A; Laugisch O; Burgin W; Sculean A; Eick S. Author NameID Maldonado, Alejandra; ORCID: http://orcid.org/0000-0002-9361-2625 Authors Full Name Maldonado, Alejandra; Laugisch, Oliver; Burgin, Walter; Sculean, Anton; Eick, Sigrun. Institution Maldonado, Alejandra. Department of Periodontology, School of Dental Medicine, University of Bern, Bern, Switzerland. [email protected]. Laugisch, Oliver. Department of Periodontology, School of Dental Medicine, University of Bern, Bern, Switzerland. Burgin, Walter. Research Section, School of Dental Medicine, University of Bern, Bern, Switzerland. Sculean, Anton. Department of Periodontology, School of Dental Medicine, University of Bern, Bern, Switzerland. Eick, Sigrun. Department of Periodontology, School of Dental Medicine, University of Bern, Bern, Switzerland. Local Messages THIS JOURNAL IS AVAILABLE IN THE BDA LIBRARY, TO REQUEST THIS ARTICLE FROM THE LIBRARY GO TO: https://www.bda.org/library/journals-articles/Documents/photocopy-request-form.pdf Abstract BACKGROUND: Considering the increasing number of elderly people, dementia has gained an important role in today's society. Although the contributing factors for dementia have not been fully understood, chronic periodontitis (CP) seems to have a possible link to dementia.

AIM: To conduct a systematic review including meta-analysis in order to assess potential differences in clinical periodontal variables between patients with dementia and non-demented individuals. METHODS: The following focused question was evaluated: is periodontitis associated with dementia? Electronic searches in two databases, MEDLINE and EMBASE, were conducted. Meta-analysis was performed with the collected data in order to find a statistically significant difference in clinical periodontal variables between the group of dementia and the cognitive normal controls. RESULTS: Forty-two articles remained for full text reading. Finally, seven articles met the inclusion criteria and only five studies provided data suitable for meta-analysis. Periodontal probing depth (PPD), bleeding on probing (BOP), gingival bleeding index (GBI), clinical attachment level (CAL), and plaque index (PI) were included as periodontal variables in the meta-analysis. Each variable revealed a statistically significant difference between the groups. In an attempt to reveal an overall difference between the periodontal variables in dementia patients and non-demented individuals, the chosen variables were transformed into units that resulted in a statistically significant overall difference (p < 0.00001). CONCLUSION: The current findings indicate that compared to systemically healthy individuals, demented patients show significantly worse clinical periodontal variables. However, further epidemiological studies including a high numbers of participants, the use of exact definitions both for dementia and chronic periodontitis and adjusted for cofounders is warranted. CLINICAL RELEVANCE: These findings appear to support the putative link between CP and dementia. Consequently, the need for periodontal screening and treatment of elderly demented people should be emphasized. Publication Type Journal Article. Review. Year of Publication 2018 <20> Unique Identifier 30049577 Title Corrigendum to "From periodontal mechanoreceptors to chewing motor control: A systematic review" [Arch. Oral Biol. 78 (2017) 109-121].[Erratum for Arch Oral Biol. 2017 Jun;78:109-121; PMID: 28226300] Source Archives of Oral Biology. 2018 Jul 23. VI 1 Status Publisher Authors Maria GP; Gaetano I; Rosangela C; Giuseppina C; Giovanna V; Pietro B; Giuseppe PA. Authors Full Name Maria, Grazia Piancino; Gaetano, Isola; Rosangela, Cannavale; Giuseppina, Cutroneo; Giovanna, Vermiglio; Pietro, Bracco; Giuseppe, Pio Anastasi. Institution Maria, Grazia Piancino. Department of Orthodontics and Gnathology-Masticatory Function, Turin University, Italy. Electronic address: [email protected]. Gaetano, Isola. Department of Orthodontics and Gnathology-Masticatory Function, Turin University, Italy. Rosangela, Cannavale. Department of Orthodontics and Gnathology-Masticatory Function, Turin University, Italy. Giuseppina, Cutroneo. Department of Biomedical Sciences and Morphological and Functional Images, Messina University, Italy. Giovanna, Vermiglio. Department of Biomedical Sciences and Morphological and Functional Images, Messina University, Italy. Pietro, Bracco. Department of Orthodontics and Gnathology-Masticatory Function, Turin University, Italy. Giuseppe, Pio Anastasi. Department of Biomedical Sciences and Morphological and Functional Images, Messina University, Italy. Local Messages THIS JOURNAL IS AVAILABLE IN THE BDA LIBRARY UP TO 2014, TO REQUEST THIS ARTICLE FROM THE LIBRARY GO TO: https://www.bda.org/library/journals-articles/Documents/photocopy-request-form.pdf Publication Type Published Erratum. Year of Publication 2018 <21> Unique Identifier 30011036 Title Impact of smoking cessation on periodontitis: A systematic review and meta-analysis of prospective longitudinal observational and interventional studies. Source Nicotine & Tobacco Research. 2018 Jul 13. VI 1 Status Publisher Authors Leite FRM; Nascimento GG; Baake S; Pedersen LD; Scheutz F; Lopez R. Authors Full Name Leite, Fabio R M; Nascimento, Gustavo G; Baake, Stina; Pedersen, Lisa D; Scheutz, Flemming; Lopez, Rodrigo. Institution

Leite, Fabio R M. Section of Periodontology, Department of Dentistry and Oral Health, Aarhus University, Aarhus, Denmark. Nascimento, Gustavo G. Section of Periodontology, Department of Dentistry and Oral Health, Aarhus University, Aarhus, Denmark. Baake, Stina. Section of Periodontology, Department of Dentistry and Oral Health, Aarhus University, Aarhus, Denmark. Pedersen, Lisa D. Section of Periodontology, Department of Dentistry and Oral Health, Aarhus University, Aarhus, Denmark. Scheutz, Flemming. Section of Periodontology, Department of Dentistry and Oral Health, Aarhus University, Aarhus, Denmark. Lopez, Rodrigo. Section of Periodontology, Department of Dentistry and Oral Health, Aarhus University, Aarhus, Denmark. Abstract Aims: This systematic review aimed to estimate the effect of tobacco smoking cessation on the risk for periodontitis compared to the risk among never-smokers and to evaluate the effect of tobacco smoking cessation on the clinical outcomes of non-surgical periodontal treatment. Methods: Electronic searches were performed in PubMed, Scopus and Embase. Search strategy included MeSH and free terms: periodontitis, periodontal diseases, smoking, tobacco use, tobacco, tobacco products, cigarette, pipe and cigar. Only original prospective longitudinal observational and interventional studies that investigated the association between smoking and periodontitis onset or progression were included. Meta-analyses were conducted to summarize the evidence. Results: 2,743 articles were identified in electronic searches; out of which only six were included in the meta-analysis. Pooled estimates showed that the risk of periodontitis incidence or progression among those who quitted smoking was not significantly different from the risk for never-smokers (RR 0.97; 95% CI 0.87-1.08). Smokers had approximately 80% higher risk of periodontitis than quitters (RR 1.79; 95%CI 1.36-2.35) and never-smokers (RR 1.82; 95%CI 1.43-2.31). Periodontal therapy resulted in up to 0.2 mm (95%CI -0.32;-0.08) higher gain in attachment level and extra 0.32 mm (95%CI 0.07;0.52) reduction in pocket depth among quitters over non-quitters after short follow-up (12-24 months). Conclusions: Few studies on the topic were identified. Smoking cessation reduced the risk for periodontitis onset and progression, and improved the outcomes of nonsurgical periodontal therapy. Implications: This review provides the first quantitative evidence of the impact of smoking cessation on the risk for periodontitis onset and progression. The findings have demonstrated that the risk for periodontitis becomes comparable to that of never-smokers and that nonsurgical periodontal treatment outcomes improve after smoking cessation. Dental professionals ought to consider smoking cessation interventions as a relevant component of the periodontal therapy. Publication Type Journal Article. Year of Publication 2018 <22> Unique Identifier 29937469 Title Contribution of Diabetes to the Incidence and Prevalence of Comorbid Conditions (Cancer, Periodontal Disease, Fracture, Impaired Cognitive Function, and Depression): A Systematic Review of Epidemiological Studies in Japanese Populations. Source Journal of Epidemiology. 2018 Jun 23. VI 1 Status Publisher Authors Tanaka H; Ihana-Sugiyama N; Sugiyama T; Ohsugi M. Author NameID Tanaka, Hirokazu; ORCID: http://orcid.org/0000-0002-3153-8802 Ihana-Sugiyama, Noriko; ORCID: http://orcid.org/0000-0002-3969-7728 Sugiyama, Takehiro; ORCID: http://orcid.org/0000-0001-5391-682X Ohsugi, Mitsuru; ORCID: http://orcid.org/0000-0002-3222-8507 Authors Full Name Tanaka, Hirokazu; Ihana-Sugiyama, Noriko; Sugiyama, Takehiro; Ohsugi, Mitsuru. Institution Tanaka, Hirokazu. Diabetes and Metabolism Information Center, Research Institute, National Center for Global Health and Medicine. Tanaka, Hirokazu. Department of Public Health, Graduate School of Medicine, the University of Tokyo. Ihana-Sugiyama, Noriko. Diabetes and Metabolism Information Center, Research Institute, National Center for Global Health and Medicine. Ihana-Sugiyama, Noriko. Department of Diabetes, Endocrinology and Metabolism, National Center for Global Health and Medicine Center Hospital. Sugiyama, Takehiro. Diabetes and Metabolism Information Center, Research Institute, National Center for Global Health and Medicine. Sugiyama, Takehiro. Department of Public Health, Graduate School of Medicine, the University of Tokyo. Ohsugi, Mitsuru. Diabetes and Metabolism Information Center, Research Institute, National Center for Global Health and Medicine. Ohsugi, Mitsuru. Department of Diabetes, Endocrinology and Metabolism, National Center for Global Health and Medicine Center Hospital. Abstract BACKGROUND: Several epidemiological studies have determined the relationship between diabetes and the incidence and/or prevalence of recently identified comorbid conditions (cancer, periodontal disease, fracture, cognitive impairment, and depression).

These relationships may vary by country or race/ethnicity. We aimed to systematically review studies in this field conducted with the Japanese population because such a review in the Japanese population has never been undertaken. METHODS: We conducted systematic literature searches in PubMed and Ichushi-Web databases for studies published until December 2016. Studies comparing the incidence and/or prevalence of the comorbidities among the Japanese population were included. The studies were classified as integrated analyses, cohort studies, case-control studies, or cross-sectional studies. RESULTS: We identified 33 studies (cancer: 17, periodontal disease: 5, fracture: 5, cognitive impairment: 4, and depression: 2). Although several cohort studies and meta-analyses had assessed the development of cancer in diabetes, there was scant epidemiological evidence for the other conditions. Indeed, only one cohort study each had been conducted for periodontal disease, fracture, and cognitive impairment, whereas other evidence was cross-sectional, some of which was induced from baseline characteristic tables of studies designed for other purposes. CONCLUSION: In Japan, there is insufficient evidence about the relationship between diabetes and the incidence/prevalence of periodontal disease, fracture, cognitive impairment, and depression. By contrast, several cohort studies and integrated analyses have been conducted for the relationship with cancer. Further studies should be undertaken to estimate the contribution of diabetes on the incidence/prevalence of comorbidities that may be specific to the Japanese population. Publication Type Journal Article. Year of Publication 2018 <23> Unique Identifier 29863310 Title How effective is adjunctive antimicrobial photodynamic therapy in treating deep periodontal pockets in periodontal disease? A systematic review. [Review] Source Journal of Investigative & Clinical Dentistry. e12345, 2018 Jun 04. VI 1 Status Publisher Authors Akram Z. Author NameID Akram, Zohaib; ORCID: http://orcid.org/0000-0001-9618-8818 Authors Full Name Akram, Zohaib. Institution Akram, Zohaib. Department of Periodontology, Faculty of Dentistry, Ziauddin University, Karachi, Pakistan. Abstract The aim of the present systematic review was to evaluate the efficacy of antimicrobial photodynamic therapy (aPDT) that is used as an adjunctive therapy with scaling and root planing (SRP) in deep periodontal pockets (>=5 mm). The addressed Patients, Intervention, Comparators, Outcomes, and Study design question was: In patients with advanced periodontitis (population), what is the effect of aPDT as adjunct to SRP (intervention) in comparison to SRP alone (comparison) on deep probing depths (outcome)? Electronic and manual literature searches were conducted using the following databases: MEDLINE, Embase, Cochrane Central Register of Controlled Trials, and Cochrane Oral Health Group Trials Register, up to and including February 2018. Six randomized trials were included. All studies used the combined approach aPDT+SRP and SRP in the test and control groups, respectively. The follow-up period ranged from 12 to 48 weeks. Wavelengths, power density, and duration of irradiation used were 670 nm, 500 mW cm-2 , and 60 seconds, respectively. All studies showed significant reduction of probing depth (PD) >=5 mm with aPDT at follow up. Considering the effects of adjunctive aPDT compared to SRP, only two studies showed additional benefit of adjunctive aPDT in reducing PD >=5 mm compared to SRP alone at follow up. The overall mean difference for PD reduction (weighted mean difference = 0.31, 95% confidence interval [CI] = -0.03 to -0.66, P = .08) was also not significant between the aPDT and SRP groups at follow up. Whether aPDT as an adjunct to SRP is efficacious in the reduction of PD >=5 mm compared to SRP alone in periodontal disease remains debatable, given that the available scientific evidence is weak. Copyright © 2018 John Wiley & Sons Australia, Ltd. Publication Type Journal Article. Review. Year of Publication 2018 <24> Unique Identifier 29858876 Title Locally delivered metformin as adjunct to scaling and root planing in the treatment of periodontal defects: A systematic review and meta-analysis. [Review] Source Journal of Periodontal Research. 2018 Jun 02. VI 1 Status Publisher

Authors Akram Z; Vohra F; Javed F. Author NameID Akram, Z; ORCID: http://orcid.org/0000-0001-9618-8818 Javed, F; ORCID: http://orcid.org/0000-0002-9253-1989 Authors Full Name Akram, Z; Vohra, F; Javed, F. Institution Akram, Z. Department of Periodontology, Faculty of Dentistry, Ziauddin University, Karachi, Pakistan. Vohra, F. Department of Prosthetic Dental Sciences, College of Dentistry, King Saud University, Riyadh, Saudi Arabia. Javed, F. Department of General Dentistry, Eastman Institute for Oral Health, University of Rochester, Rochester, NY, USA. Local Messages THIS JOURNAL IS AVAILABLE IN THE BDA LIBRARY, TO REQUEST THIS ARTICLE FROM THE LIBRARY GO TO: https://www.bda.org/library/journals-articles/Documents/photocopy-request-form.pdf Abstract This study aimed to evaluate the efficacy of metformin as an adjunct to scaling and root planing (SRP) in the treatment of chronic periodontitis. Electronic searches were conducted in databases (MEDLINE, EMBASE, Cochrane Central Register of Controlled Trials and Cochrane Oral Health Group Trials Register databases) up to August 2017. Randomized clinical trials with data in comparison between adjunctive locally delivered metformin use to SRP and placebo in each group and a follow-up period of at least 6 months, were included. Primary outcomes included clinical attachment level, while secondary outcomes were bone defect (BD) fill and reduction in probing depth. The weighted mean differences (WMD) of outcomes and 95% confidence intervals (CI) for each variable were calculated using the random effects model. Five clinical studies were included in the qualitative synthesis and 3 studies were included for meta-analysis. All the included studies showed significant BD fill, probing depth reduction and clinical attachment level gain with adjunctive locally delivered metformin compared to SRP alone. Considering the effects of adjunctive metformin as compared to SRP, a high degree of heterogeneity for BD fill (Q value = 7.03, P = .02, I2 = 71.55%) was noticed among both the groups. Meta-analysis showed a statistically significant clinical attachment level gain (WMD = -2.83, 95% CI = -3.32 to -2.34, P < .001), BD fill (WMD = -2.96, 95% CI = -3.99 to -1.93, P < .001) and probing depth reduction (WMD = -3.11, 95% CI = -3.63 to -2.59, P < .001) for SRP + metformin treatment vs SRP. Adjunctive use of metformin delivery in periodontal treatment appears to be effective in BD fill, reducing probing depth and gain in clinical attachment level. Further multicentered randomized clinical trials are warranted in future to prove additional benefits of metformin as an adjunct to SRP in the treatment of chronic periodontitis. Copyright © 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. Publication Type Journal Article. Review. Year of Publication 2018 <25> Unique Identifier 29377446 Title Association between periodontitis and chronic kidney disease: Systematic review and meta-analysis. [Review] Source Oral Diseases. 2018 Jan 27. VI 1 Status Publisher Authors Deschamps-Lenhardt S; Martin-Cabezas R; Hannedouche T; Huck O. Authors Full Name Deschamps-Lenhardt, S; Martin-Cabezas, R; Hannedouche, T; Huck, O. Institution Deschamps-Lenhardt, S. Faculte de chirurgie-dentaire, Periodontology, Universite de Strasbourg, Strasbourg, France. Deschamps-Lenhardt, S. Pole de medecine et chirurgie bucco-dentaire, Hopitaux universitaires de Strasbourg, Strasbourg, France. Martin-Cabezas, R. Faculte de chirurgie-dentaire, Periodontology, Universite de Strasbourg, Strasbourg, France. Martin-Cabezas, R. Pole de medecine et chirurgie bucco-dentaire, Hopitaux universitaires de Strasbourg, Strasbourg, France. Hannedouche, T. Faculte de Medecine, Universite de Strasbourg et Service de nephrologie, Hopitaux Universitaires de Strasbourg, Strasbourg, France. Huck, O. Faculte de chirurgie-dentaire, Periodontology, Universite de Strasbourg, Strasbourg, France. Huck, O. Pole de medecine et chirurgie bucco-dentaire, Hopitaux universitaires de Strasbourg, Strasbourg, France. Huck, O. INSERM (French National Institute of Health and Medical Research), Regenerative Nanomedicine, UMR 1260, Federation de Medecine Translationnelle de Strasbourg (FMTS), Strasbourg, France. Local Messages THIS JOURNAL IS AVAILABLE IN THE BDA LIBRARY, TO REQUEST THIS ARTICLE FROM THE LIBRARY GO TO: https://www.bda.org/library/journals-articles/Documents/photocopy-request-form.pdf Abstract A systematic review and meta-analysis were conducted to evaluate the association between periodontitis (PD) and chronic kidney disease (CKD) and to explore the potential influence of periodontal treatment in patients with CKD. Databases (PubMed, Web of Science, Science direct, Cochrane Database) were screened for relevant articles, focusing on the periodontal status of patients with CKD, published until December 2017. Five hundred and fifty-three articles were identified, and 37 fulfilled the inclusion criteria and were considered in this systematic review. Seventeen articles were included in the meta-analysis and 7 in the review focusing on the impact of periodontal treatment. Most of the identified studies indicated an increased incidence of PD in patients with CKD. Meta-analysis showed an association between CKD and PD, and strength of this association was increased

when severe PD was considered (OR = 2.39 (1.70-3.36)). The association could be observed even after adjustment for major CKD risk factors or use of precise diagnosis criteria (OR = 2.26 for severe PD (1.69-3.01)). Analysis of cohort studies indicated an incident rate ratio (IRR) of 1.73. Periodontitis is associated with CKD after multivariable adjustment. Further studies are necessary to determine whether prevention or treatment of PD can reduce the incidence and/or severity of CKD. Copyright © 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. All rights reserved. Publication Type Journal Article. Review. Year of Publication 2018 <26> Unique Identifier 29359889 Title Periodontal and chronic kidney disease association: a systematic review and meta-analysis. Source Nephrology. 2018 Jan 23. VI 1 Status Publisher Authors Kapellas K; Singh A; Bertotti M; Nascimento G; Jamieson LM; Perio-CKD collaboration. Author NameID Kapellas, Kostas; ORCID: http://orcid.org/0000-0002-3761-9953 Authors Full Name Kapellas, Kostas; Singh, Ankur; Bertotti, Maite; Nascimento, Gustavo; Jamieson, Lisa M; Perio-CKD collaboration. Institution Kapellas, Kostas. Australian Research Centre for Population Oral Health, The University of Adelaide, South Australia, Australia. Singh, Ankur. Australian Research Centre for Population Oral Health, The University of Adelaide, South Australia, Australia. Singh, Ankur. Melbourne School of Population and Global Health, The University of Melbourne, Australia. Bertotti, Maite. School of Dentistry, Universidade Federal do Rio Grande do Sul, Brazil. Nascimento, Gustavo. Department of Dentistry and Oral Health, Aarhus Universitet Institut for Odontologi, Aarhus, Denmark. Jamieson, Lisa M. Australian Research Centre for Population Oral Health, The University of Adelaide, South Australia, Australia. Abstract AIM: Chronic kidney disease (CKD) and kidney failure is increasing globally and evidence from observational studies suggest periodontal disease may contribute to kidney functional decline. METHODS: Electronic searches of the PubMed, EMBASE, Web of Science, Scopus and Cochrane Library databases were conducted for the purposes of conducting a systematic review. Hand searching of reference lists was also performed. Meta-analysis of observational studies involving periodontal disease and chronic kidney disease in adults was performed. RESULTS: A total of 17 studies were selected from an initial 4,055 abstracts. Pooled estimates indicated the odds of having CKD were 60% higher among patients with periodontitis: pooled OR 1.60 (95% CI 1.44 - 1.79, I2 35.2%, P=0.11) compared to those without. Conversely, a similar magnitude but non-significant higher odds of having periodontal disease was found among people with CKD 1.69 (95% CI: 0.84, 3.40, I2 =89.8%, P<0.00) versus non-CKD. Meta-regression revealed study quality based on the Newcastle-Ottawa Scale and statistical adjustment for potential confounders explained almost 35% of the heterogeneity in the studies investigating the association between CKD and periodontitis. CONCLUSIONS: Moderate evidence for a positive association between periodontitis and CKD exists. Evidence for the opposite direction is extremely weak based on significant heterogeneity between studies. Copyright This article is protected by copyright. All rights reserved. Publication Type Journal Article. Year of Publication 2018 <27> Unique Identifier 30348144 Title The role of three interleukin 10 gene polymorphisms (- 1082 A > G, - 819 C > T, - 592 A > C) in the risk of chronic and aggressive periodontitis: a meta-analysis and trial sequential analysis. Source BMC Oral Health. 18(1):171, 2018 Oct 22. VI 1 Status In-Data-Review Authors Wong HC; Ooi Y; Pulikkotil SJ; Naing C. Author NameID Naing, Cho; ORCID: http://orcid.org/0000-0003-3425-7149 Authors Full Name Wong, Hey Chiann; Ooi, Yuxuan; Pulikkotil, Shaju Jacob; Naing, Cho.

Institution Wong, Hey Chiann. School of Dentistry, International Medical University, Kuala Lumpur, Malaysia. Ooi, Yuxuan. School of Dentistry, International Medical University, Kuala Lumpur, Malaysia. Pulikkotil, Shaju Jacob. School of Dentistry, International Medical University, Kuala Lumpur, Malaysia. Naing, Cho. Institute for Research, Development and Innovation (IRDI), International Medical University, 5700, Kuala Lumpur, Malaysia. [email protected]. Naing, Cho. Division of Tropical Heath and Medicine, James Cook University, Townsville, Australia. [email protected]. Abstract BACKGROUND: Periodontitis is a major oral health problem and it is considered as one of the reasons for tooth loss in developing and developed nations. The objective of the current review was to investigate the association between IL10 polymorphisms - 1082 A > G (rs1800896), -819C > T (rs1800871), - 592 A > C (rs1800872) and the risk of either chronic periodontitis or aggressive periodontitis. METHODS: This is a meta- analysis study, following the preferred reporting items for systematic reviews and meta- analyses (PRISMA). Relevant studies were searched in the health related electronic databases. Methodological quality of the included studies were assessed using the Newcastle-Ottawa Scale. For individual studies, odds ratio (OR) and its 95%confidence interval (CI) were calculated to assess the strength of association between IL10 polymorphisms (- 1082 A > G, -819C > T, - 592 A > C) and the risk of periodontitis. For pooling of the estimates across studies included, the summary OR and its 95% CIs were calculated with random-effects model. The pooled estimates were done under four genetic models such as the allelic contrast model, the recessive model, the dominant model and the additive model. Trial sequential analysis (TSA) was done for estimation of the required information size for this meta-analysis study. RESULTS: Sixteen studies were identified for this review. The included studies were assessed to be of moderate to good methodological quality. A significant association between polymorphism of IL10-1082 A > G polymorphism and the risk of chronic periodontitis in the non-Asian populations was observed only in the recessive model (OR,1.42; 95% CI:1.11, 1.8,I2: 43%). The significant associations between - 592 A > C polymorphism and the risk of aggressive periodontitis in the non-Asian populations were observed in particular genetic models such as allele contrast (OR, 4.34; 95%CI:1.87,10.07,I2: 65%) and recessive models (OR, 2.1; 95% CI:1.16, 3.82,I2: 0%). The TSA plot revealed that the required information size for evidence of effect was sufficient to draw a conclusion. CONCLUSIONS: This meta-analysis suggested that the IL10-1082 A > G polymorphism was associated with chronic periodontitis CP risk in non-Asians. Thus, in order to further establish the associations between IL10 (- 819 C > T, - 592 A > C) in Asian populations, future studies should include larger sample sizes with multi-ethnic groups. Publication Type Journal Article. Year of Publication 2018 <28> Unique Identifier 30327689 Title Contribution of Interleukin-10-592 (-590, -597) C>A Polymorphisms to Periodontitis Susceptibility: An Updated Meta-Analysis Based on 18 Case-Control Studies. [Review] Source Disease Markers. 2018:2645963, 2018. VI 1 Status In-Process Authors Li Y; Feng G; Deng Y; Song J. Author NameID Song, Jinglin; ORCID: https://orcid.org/0000-0002-0224-6640 Authors Full Name Li, Yao; Feng, Ge; Deng, Yuejia; Song, Jinglin. Institution Li, Yao. Department of Periodontology, Stomatological College, Chongqing Medical University, Chongqing 400016, China. Feng, Ge. Department of Periodontology, Stomatological College, Chongqing Medical University, Chongqing 400016, China. Deng, Yuejia. Department of Periodontology, Stomatological College, Chongqing Medical University, Chongqing 400016, China. Song, Jinglin. Department of Periodontology, Stomatological College, Chongqing Medical University, Chongqing 400016, China. Abstract Introduction: The association between interleukin-10- (IL-10-) 592 (-590, -597) C>A polymorphisms and susceptibility to chronic or aggressive periodontitis (CP or AgP) is conflicting. This meta-analysis is aimed at quantitatively estimating the association. Materials and Methods: PubMed, Embase, Web of Science, and WANFAN were searched for studies performed prior to January 31, 2018, to collect data for our research. Meta-analysis was performed using RevMan 5.3 or STATA 14.0. Results: In total, 18 studies that met our criteria were included. Overall or HWE subgroup analysis of individuals with this polymorphism revealed that in terms of CP susceptibility, there was a significant difference between case groups and control groups in the A allele versus C allele model (OR = 1.38, 95% CI = 1.17-1.64 or OR = 1.38, 95% CI = 1.12-1.70), in the AA versus CC+CA model (OR = 1.49, 95% CI =1.06-2.10 or OR = 1.42, 95% CI = 1.13-1.78), and in the CC versus CA+AA model (OR = 0.69, 95% CI = 0.51-0.92 or OR = 0.68, 95% CI = 0.49-0.93); subgroup analysis based on a nonsmoking population also displayed significance in the A allele versus C allele model (OR = 1.43, 95% CI = 1.15-1.79) and CC versus CA+AA model (OR = 0.62, 95% CI = 0.44-0.87). For this polymorphisms and AgP susceptibility, our analyses revealed a significant association in both the A allele versus C allele model (OR = 1.29, 95% CI = 1.01-1.63) and the AA versus CC+CA model (OR = 1.93, 95% CI = 1.30-2.89);

subgroup analysis based on Caucasian or nonsmoking populations showed significant differences in the AA versus CC+CA model (OR = 6.29, 95% CI = 1.78-22.21 or OR = 3.24, 95% CI = 1.59-6.61). Conclusions: IL-10-592 (-590, -597) A allele and the associated AA genotype may be risk factors for the onset of CP or AgP-particularly for the AA genotype and the increased risk of AgP in Caucasian or nonsmoking populations. Conversely, the CC genotype may act as a protective factor against the onset of CP. Publication Type Journal Article. Review. Year of Publication 2018 <29> Unique Identifier 30289123 Title Clinical Effectiveness of Er: YAG Lasers Adjunct to Scaling and Root Planing in Non-Surgical Treatment of Chronic Periodontitis: A Meta-Analysis of Randomized Controlled Trials. Source Medical Science Monitor. 24:7090-7099, 2018 Oct 05. VI 1 Status In-Process Authors Ma L; Zhang X; Ma Z; Shi H; Zhang Y; Wu M; Cui W. Authors Full Name Ma, Lei; Zhang, Xiaolin; Ma, Zhe; Shi, Hong; Zhang, Yanning; Wu, Mingxuan; Cui, Wei. Institution Ma, Lei. College and Hospital of Stomatology, Hebei Medical University, Shijiazhuang, Hebei, China (mainland). Zhang, Xiaolin. Department of Epidemiology and Statistics, School of Public Health, Hebei Medical University; Hebei Province Center for Disease Prevention and Control, Shijiazhuang, Hebei, China (mainland). Ma, Zhe. College and Hospital of Stomatology, Hebei Medical University, Shijiazhuang, Hebei, China (mainland). Shi, Hong. College and Hospital of Stomatology, Hebei Medical University, Shijiazhuang, Hebei, China (mainland). Zhang, Yanning. College and Hospital of Stomatology, Hebei Medical University, Shijiazhuang, Hebei, China (mainland). Wu, Mingxuan. College and Hospital of Stomatology, Hebei Medical University, Shijiazhuang, Hebei, China (mainland). Cui, Wei. Department of Stomatology, No. 2 Hospital of Baoding, Baoding, Hebei, China (mainland). Abstract BACKGROUND Er: YAG lasers (ERLs) show suitable characteristics for scaling and root planing, but previous studies have drawn conflicting conclusions. This meta-analysis aimed to systematically appraise the available evidence concerning the effectiveness of ERLs as an adjunct to scaling and root planing (SRP) for non-surgical periodontal treatment. MATERIAL AND METHODS Randomized controlled trials (RCTs) comparing ERLs+SRP with SRP alone for the treatment of chronic periodontitis were searched in 9 electronic biomedical databases up to January 2018. The weighted mean differences (WMDs) and 95% confidence intervals (CIs) were counted for probing depth (PD) reduction, clinical attachment level (CAL) gain, and visual analog scale (VAS) score. Heterogeneity was evaluated with the I2 statistic for interstudy comparisons and the chi2-based Q statistic for intra-study comparisons. Sensitivity analysis was conducted by switching to a random or fixed effect model based on the heterogeneity. Publication bias was measured by Begg's test. RESULTS Ten related RCTs met the inclusion criteria. There were statistically significant differences in the assessed clinical parameters at the three-month follow-up: PD reduction (WMD=0.32, 95%CI range from 0.14 to 0.51, p<0.001; p=0.003, I2=69.7%); CAL gain (WMD=0.31, 95%CI range from 0.22 to 0.40, p<0.001; p=0.209, I2=28.8%); and VAS scores (WMD=-1.38, 95%CI range from -2.45 to -0.31, p<0.001; p=0.182, I2=44%). There were no significant differences at the six- and twelve-month follow-ups. Sensitivity analysis revealed that the results were consistent. No evidence of publication bias was detected. CONCLUSIONS This systematic analysis demonstrated that ERLs+SRP provides additional short-term effectiveness and that patients experience less pain compared to SRP. There were no significant differences at the medium-term and long-term follow-ups. Long-term well-designed RCTs are required. Publication Type Journal Article. Year of Publication 2018 <30> Unique Identifier 30076616 Title The effect of periodontal therapy on oxidative stress biomarkers: A systematic review. [Review] Source Journal of Clinical Periodontology. 45(10):1222-1237, 2018 Oct. VI 1 Status In-Data-Review Authors da Silva JC; Muniz FWMG; Oballe HJR; Andrades M; Rosing CK; Cavagni J. Author NameID Muniz, Francisco Wilker Mustafa Gomes; ORCID: http://orcid.org/0000-0002-3945-1752 Authors Full Name da Silva, Julia Christ; Muniz, Francisco Wilker Mustafa Gomes; Oballe, Harry Juan Rivera; Andrades, Michael; Rosing, Cassiano Kuchenbecker; Cavagni, Juliano. Institution

da Silva, Julia Christ. Federal University Rio Grande do Sul, Porto Alegre, Brazil. Muniz, Francisco Wilker Mustafa Gomes. Department of Periodontology, Federal University Pelotas, Pelotas, Brazil. Oballe, Harry Juan Rivera. Department of Periodontology, Federal University Rio Grande do Sul, Porto Alegre, Brazil. Andrades, Michael. Experimental Research Center, Hospital de Clinicas de Porto Alegre, Porto Alegre, Brazil. Rosing, Cassiano Kuchenbecker. Department of Periodontology, Federal University Rio Grande do Sul, Porto Alegre, Brazil. Cavagni, Juliano. Department of Periodontology, Federal University Rio Grande do Sul, Porto Alegre, Brazil. Local Messages THIS JOURNAL IS AVAILABLE IN THE BDA LIBRARY, TO REQUEST THIS ARTICLE FROM THE LIBRARY GO TO: https://www.bda.org/library/journals-articles/Documents/photocopy-request-form.pdf Abstract AIM: To systematically review the literature about the effect of periodontal treatment on oxidative stress (OxS) biomarkers. MATERIAL AND METHODS: Three databases (PubMed, EMBASE, and Scopus) were searched up to February 2018. Clinical trials with a follow-up of at least 6 weeks after mechanical periodontal treatment were included. Due to the high heterogeneity among the units and indices of measurements used in the studies, a meta-analysis was not performed. RESULTS: Overall, 3,199 studies were retrieved, of which 20 were included. Four studies were randomized clinical trials (RCT), and 16 studies were non-RCTs. The most common OxS biomarkers used were 8-hydroxydeoxiguanosine (8-OHdG), total oxidant status (TOS), and total antioxidant status (TAS). After treatment, most of the studies reported a decrease in 8-OHdG concentration in the gingival crevicular fluid (GCF) and saliva. In addition, the salivary concentration of this biomarker was similar to periodontally healthy patients. Periodontal therapy was effective in reducing TOS in GCF, saliva, and serum in most studies. TAS, however, responded inconsistently to the periodontal intervention. CONCLUSION: Periodontal therapy reduces the levels of OxS biomarkers, even to values similar to those found in periodontally healthy individuals. Additional RCTs are warranted, as the information is mainly based on nonrandomized studies. Copyright © 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. Publication Type Journal Article. Review. Year of Publication 2018 <31> Unique Identifier 30328312 Title Local drug delivery in periodontitis treatment: A review of contemporary literature. [Review] Source Dental & Medical Problems. 55(3):333-342, 2018 Jul-Sep. VI 1 Status In-Data-Review Authors Szulc M; Zakrzewska A; Zborowski J. Authors Full Name Szulc, Malgorzata; Zakrzewska, Aneta; Zborowski, Jacek. Institution Szulc, Malgorzata. Department of Periodontology, Wroclaw Medical University, Poland. Zakrzewska, Aneta. Department of Periodontology, Wroclaw Medical University, Poland. Zborowski, Jacek. Department of Periodontology, Wroclaw Medical University, Poland. Abstract Traditional methods of non-surgical treatment of periodontitis, including mechanical scaling/root planing (SRP), do not guarantee remission of the disease. Local delivery of antimicrobial agents in periodontitis entails antimicrobial therapy placed directly in periodontal pockets. The advantage of this form of treatment is that the concentration of the drug after application significantly exceeds the minimum inhibitory concentration (MIC) and persists for up to several weeks. Therefore, many systems of locally applied devices, using a variety of antibiotics or antiseptics have been developed. There is continuous research aimed at introducing new forms of locally administered drugs, some of which have not proved to be effective, while others are promising. For almost 30 years such systems have been used for treatment as an adjuvant to SRP, and their efficacy has been evaluated. The aim of this article is to systematically review the contemporary literature regarding the currently available chemotherapeutics locally administered in the treatment of periodontitis. Publication Type Journal Article. Review. Year of Publication 2018 <32> Unique Identifier 30045652 Title Behavioural interventions that have the potential to improve self-care in adults with periodontitis: a systematic review. Source Acta Odontologica Scandinavica. 76(8):612-620, 2018 Nov. VI 1 Status In-Process

Authors Jarvinen M; Stolt M; Honkala E; Leino-Kilpi H; Pollanen M. Authors Full Name Jarvinen, Mirkka; Stolt, Minna; Honkala, Eino; Leino-Kilpi, Helena; Pollanen, Marja. Institution Jarvinen, Mirkka. a Institute of Dentistry , University of Turku , Turku , Finland. Stolt, Minna. b Department of Nursing Science , University of Turku , Turku , Finland. Honkala, Eino. c Department of Clinical Dentistry , University of Tromso , Tromso , Norway. Leino-Kilpi, Helena. b Department of Nursing Science , University of Turku , Turku , Finland. Pollanen, Marja. a Institute of Dentistry , University of Turku , Turku , Finland. Local Messages THIS JOURNAL IS AVAILABLE IN THE BDA LIBRARY, TO REQUEST THIS ARTICLE FROM THE LIBRARY GO TO: https://www.bda.org/library/journals-articles/Documents/photocopy-request-form.pdf Abstract AIM: To evaluate behavioural and educational interventions used to improve self-care in adult periodontitis patients in comparison with conventional instruction. METHODS: A systematic electronic search of empirical studies that were published up to June 2017 using the MEDLINE database was performed. The reference lists of all of the included studies and articles from six separate journals were manually searched. RESULTS: A total of 1806 articles were identified. Six articles fulfilled the inclusion and exclusion criteria. The interventions used in periodontal treatment had theoretical backgrounds of cognitive behavioural approach, self-regulation theory of Leventhal, motivational interviewing and a client self-care commitment model. The control group in each study was described receiving conventional information. The outcomes of the interventions were classified into three categories: 1) clinical findings 2) self-reported self-care and 3) patient evaluations of the intervention. The behavioural intervention groups seemed to perform slightly better than the control groups when clinical outcome measures such as the presence of plaque or number of periodontal pockets were used. Furthermore, behavioural interventions increased patient reported compliance (e.g. effectiveness of self-care and frequency of interdental cleaning). The different behavioural techniques all seemed to work more effectively than conventional instruction. No behavioural technique could be identified superior to the other. CONCLUSIONS: The behavioural interventions seem to be beneficial for patient adherence and may therefore improve periodontal treatment success. However, there is a need to further explore the use of different methods in studies with larger sample sizes, longer follow-up times and both behavioural and clinical outcome measures. Publication Type Journal Article. Year of Publication 2018 <33> Unique Identifier 30148466 Title Periodontal therapy for patients before and after radiotherapy: A review of the literature and topics of interest for clinicians. Source Medicina Oral, Patologia Oral y Cirugia Bucal. 23(5):e524-e530, 2018 Sep 01. VI 1 Status In-Process Authors Irie MS; Mendes EM; Borges JS; Osuna LG; Rabelo GD; Soares PB. Authors Full Name Irie, M-S; Mendes, E-M; Borges, J-S; Osuna, L-G-G; Rabelo, G-D; Soares, P-B-F. Institution Irie, M-S. Universidade Federal de Uberlandia, Faculdade de Odontologia, Av. Para, 1720, Bloco 4L, Anexo A, Campos Umuarama, CEP: 38400-902, Uberlandia, Minas Gerais, Brazil, [email protected]. Abstract BACKGROUND: To review and discuss important topics regarding periodontal treatment pre- and post-radiotherapy for head and neck cancer in human patients; to discuss the references for adequate techniques, the appropriate moment for tooth extractions and periodontal management; and to discuss the prevention of osteoradionecrosis. MATERIAL AND METHODS: Thirty-nine studies including original studies, randomized clinical trials (RCTs) and reviews were searched in online databases MEDLINE (PubMed) and the Cochrane library. No year of publication restriction was applied. RESULTS: Language was restricted to English, and the following Medical Subject Heading terms were used: radiotherapy, radiation therapy and periodontal treatment. Studies regarding periodontal treatment and tooth extraction that involved clinical management of irradiated patients were selected. CONCLUSIONS: The treatment of periodontal diseases before radiotherapy is mainly required to avoid future dental extraction and to reduce the development of osteoradionecrosis. Periodontal treatment in irradiated patients mostly includes scaling and root planing, extraction of condemned teeth and topical and systemic antimicrobial therapy. Tooth removal should be planned at least 14 days before the first day of radiation treatment. Particular care and mouthwashes should be taken during and after radiation.

CLINICAL SIGNIFICANCE: The management of irradiated patients represents a challenge for health professionals, including dentists. It is important to establish recommendations for clinicians concerning dental and periodontal management in irradiated patients before, during and after treatment. Publication Type Journal Article. Year of Publication 2018 <34> Unique Identifier 30281706 Title Effects of smoking on tooth loss among individuals under periodontal maintenance therapy: a systematic review and meta-analysis. Source Cadernos de Saude Publica. 34(9):e00024918, 2018 Sep 21. VI 1 Status In-Data-Review Authors Vieira TR; Martins CC; Cyrino RM; Azevedo AMO; Cota LOM; Costa FO. Authors Full Name Vieira, Thais Ribeiral; Martins, Carolina Castro; Cyrino, Renata Magalhaes; Azevedo, Andrea Mara Oliveira; Cota, Luis Otavio Miranda; Costa, Fernando Oliveira. Institution Vieira, Thais Ribeiral. Faculdade de Odontologia, Universidade Federal de Minas Gerais, Belo Horizonte, Brasil. Martins, Carolina Castro. Faculdade de Odontologia, Universidade Federal de Minas Gerais, Belo Horizonte, Brasil. Cyrino, Renata Magalhaes. Faculdade de Odontologia, Universidade Federal de Minas Gerais, Belo Horizonte, Brasil. Azevedo, Andrea Mara Oliveira. Faculdade de Odontologia, Universidade Federal de Minas Gerais, Belo Horizonte, Brasil. Cota, Luis Otavio Miranda. Faculdade de Odontologia, Universidade Federal de Minas Gerais, Belo Horizonte, Brasil. Costa, Fernando Oliveira. Faculdade de Odontologia, Universidade Federal de Minas Gerais, Belo Horizonte, Brasil. Abstract Dental mortality has been reported by longitudinal studies on periodontal maintenance therapy (PMT), but the independent effect of smoking on tooth loss (TL), adjusted for important confounding variables, has been poorly evaluated. This systematic review aimed to assess and analyze the isolated effect of smoking TL among individuals undergoing PMT. Electronic, manual, grey literature, and recent articles (from April 2018) were searched, with no restriction regarding language; respective dates of publication were included. Epidemiological clinical studies reporting TL data among smokers undergoing PMT in comparison to nonsmoker control groups were selected. Methodological quality was assessed using the Newcastle-Ottawa Scale. Meta-analysis was performed, as well as I2 heterogeneity and sensitivity tests. Evidence quality was assessed using GRADE (Grading of Recommendations, Assessment, Development and Evaluation). Eleven papers were included in the systematic review: four case-control and seven cohort studies. Ten out of the 11 studies concluded that smoking was an important risk factor for the occurrence of TL. Meta-analysis of four of the cohort studies found that smokers had 3.24 times the chance of occurrence of TL than nonsmokers undergoing PMT (95%CI: 1.33-7.90). Overall, studies' risk of bias was low. The quality of the scientific evidence moderately supports that smokers undergoing PMT have a greater chance of TL than nonsmokers. Publication Type Journal Article. Year of Publication 2018 <35> Unique Identifier 30259968 Title Systemic antibiotics for symptomatic apical periodontitis and acute apical abscess in adults. [Review][Update of Cochrane Database Syst Rev. 2014 Jun 26;(6):CD010136; PMID: 24967571] Source Cochrane Database of Systematic Reviews. 9:CD010136, 2018 09 27. VI 1 Status In-Process Authors Cope AL; Francis N; Wood F; Chestnutt IG. Authors Full Name Cope, Anwen L; Francis, Nick; Wood, Fiona; Chestnutt, Ivor G. Institution Cope, Anwen L. Cardiff and Vale University Health Board, Heath Park, Cardiff, UK, CF14 4YS. Abstract BACKGROUND: Dental pain can have a detrimental effect on quality of life. Symptomatic apical periodontitis and acute apical abscess are common causes of dental pain and arise from an inflamed or necrotic dental pulp, or infection of the pulpless root canal system. Clinical guidelines recommend that the first-line treatment for teeth with these conditions should be removal of the source of inflammation or infection by local, operative measures, and that systemic antibiotics are currently only recommended for situations where there is evidence of spreading infection (cellulitis, lymph node involvement, diffuse swelling) or systemic involvement (fever, malaise). Despite this, there is evidence that dentists frequently prescribe antibiotics in the absence of these signs. There is concern that this could contribute to the development of antibiotic-resistant bacterial colonies within both the individual and the community. This review is an update of the original version that was published in 2014.

OBJECTIVES: To evaluate the effects of systemic antibiotics provided with or without surgical intervention (such as extraction, incision and drainage of a swelling, or endodontic treatment), with or without analgesics, for symptomatic apical periodontitis and acute apical abscess in adults. SEARCH METHODS: Cochrane Oral Health's Information Specialist searched the following databases: Cochrane Oral Health's Trials Register (to 26 February 2018), the Cochrane Central Register of Controlled Trials (CENTRAL; 2018, Issue 1) in the Cochrane Library (searched 26 February 2018), MEDLINE Ovid (1946 to 26 February 2018), Embase Ovid (1980 to 26 February 2018), and CINAHL EBSCO (1937 to 26 February 2018). The US National Institutes of Health Ongoing Trials Register (ClinicalTrials.gov) and the World Health Organization International Clinical Trials Registry Platform were searched for ongoing trials. A grey literature search was conducted using OpenGrey (to 26 February 2018) and ZETOC Conference Proceedings (1993 to 26 February 2018). No restrictions were placed on the language or date of publication when searching the electronic databases. SELECTION CRITERIA: Randomised controlled trials of systemic antibiotics in adults with a clinical diagnosis of symptomatic apical periodontitis or acute apical abscess, with or without surgical intervention (considered in this situation to be extraction, incision and drainage or endodontic treatment) and with or without analgesics. DATA COLLECTION AND ANALYSIS: Two authors screened the results of the searches against inclusion criteria, extracted data and assessed risk of bias independently and in duplicate. We calculated mean differences (MD) (standardised mean difference (SMD) when different scales were reported) and 95% confidence intervals (CI) for continuous data. A fixed-effect model was used in the meta-analysis as there were fewer than four studies. We contacted study authors to obtain missing information. MAIN RESULTS: We included two trials in this review, with 62 participants included in the analyses. Both trials were conducted in university dental schools in the USA and compared the effects of oral penicillin V potassium (penicillin VK) versus a matched placebo when provided in conjunction with a surgical intervention (total or partial pulpectomy) and analgesics to adults with acute apical abscess or symptomatic necrotic tooth. The patients included in these trials had no signs of spreading infection or systemic involvement (fever, malaise). We assessed one study as having a high risk of bias and the other study as having unclear risk of bias.The primary outcome variables reported in both studies were participant-reported pain and swelling (one trial also reported participant-reported percussion pain). One study reported the type and number of analgesics taken by participants. One study recorded the incidence of postoperative endodontic flare-ups (people who returned with symptoms that necessitated further treatment). Adverse effects, as reported in one study, were diarrhoea (one participant, placebo group) and fatigue and reduced energy postoperatively (one participant, antibiotic group). Neither study reported quality of life measurements.Objective 1: systemic antibiotics versus placebo with surgical intervention and analgesics for symptomatic apical periodontitis or acute apical abscessTwo studies provided data for the comparison between systemic antibiotics (penicillin VK) and a matched placebo for adults with acute apical abscess or a symptomatic necrotic tooth when provided in conjunction with a surgical intervention. Participants in one study all underwent a total pulpectomy of the affected tooth, while participants in the other study had their tooth treated by either partial or total pulpectomy. Participants in both trials received oral analgesics. There were no statistically significant differences in participant-reported measures of pain or swelling at any of the time points assessed within the review. The MD for pain (short ordinal numerical scale 0 to 3) was -0.03 (95% CI -0.53 to 0.47) at 24 hours; 0.32 (95% CI -0.22 to 0.86) at 48 hours; and 0.08 (95% CI -0.38 to 0.54) at 72 hours. The SMD for swelling was 0.27 (95% CI -0.23 to 0.78) at 24 hours; 0.04 (95% CI -0.47 to 0.55) at 48 hours; and 0.02 (95% CI -0.49 to 0.52) at 72 hours. The body of evidence was assessed as at very low quality.Objective 2: systemic antibiotics without surgical intervention for adults with symptomatic apical periodontitis or acute apical abscessWe found no studies that compared the effects of systemic antibiotics with a matched placebo delivered without a surgical intervention for symptomatic apical periodontitis or acute apical abscess in adults. AUTHORS' CONCLUSIONS: There is very low-quality evidence that is insufficient to determine the effects of systemic antibiotics on adults with symptomatic apical periodontitis or acute apical abscess. Publication Type Journal Article. Review. Research Support, Non-U.S. Gov't. Year of Publication 2018 <36> Unique Identifier 30280756 Title Relationship between oral microbiota and periodontal disease: a systematic review. Source European Review for Medical & Pharmacological Sciences. 22(18):5775-5788, 2018 Sep. VI 1 Status In-Data-Review Authors Patini R; Staderini E; Lajolo C; Lopetuso L; Mohammed H; Rimondini L; Rocchetti V; Franceschi F; Cordaro M; Gallenzi P. Authors Full Name Patini, R; Staderini, E; Lajolo, C; Lopetuso, L; Mohammed, H; Rimondini, L; Rocchetti, V; Franceschi, F; Cordaro, M; Gallenzi, P. Institution Patini, R. Institute of Dentistry and Maxillofacial Surgery, Fondazione Policlinico Universitario A. Gemelli IRCCS, Roma, Universita Cattolica del Sacro Cuore. [email protected]. Abstract OBJECTIVE: In recent years metagenomic analysis has become more accessible for the characterization of biological specimens. There has been an important increase of studies using this technique for subgingival human samples. To date, there are no updated systematic reviews on the relationship between oral microbiota and periodontal disease. The aim of the present systematic review was to update data about studies concerning the influences of changes in oral microbiota composition on the periodontal status in human subjects.

MATERIALS AND METHODS: An electronic search was conducted in four databases (MEDLINE, Scopus, CENTRAL and Web of Science) for articles published in English from January 2014 to April 2018. In vitro or animal studies, case reports, case series, retrospective studies, review articles, abstracts and discussions were excluded. Also, studies that evaluated less than 5 microbial species, only viruses or already known periodontal pathogens were excluded. Two independent researches selected the studies and extracted the data. The quality of evidence was assessed as high, moderate or low for each microorganism. RESULTS: Eight studies and three additional publications recovered from the bibliography search of the selected articles were included in the review. The Bacteria domain was the main detected among the others and it included 53 species. The review confirmed the presence of recognized periodontal pathogens such as the members of the red complex but also identified, with high weight of evidence, the presence of new pathogens. CONCLUSIONS: The results of this systematic review support high evidence for the association of 3 new species/genera with the etiology of periodontitis. Future investigations on the actual role of these new pathogens in the onset and progression of the disease are needed. Publication Type Journal Article. Year of Publication 2018 <37> Unique Identifier 29903685 Title Periodontal Disease, Systemic Inflammation and the Risk of Cardiovascular Disease. [Review] Source Heart, Lung & Circulation. 27(11):1327-1334, 2018 Nov. VI 1 Status In-Process Authors Carrizales-Sepulveda EF; Ordaz-Farias A; Vera-Pineda R; Flores-Ramirez R. Authors Full Name Carrizales-Sepulveda, Edgar Francisco; Ordaz-Farias, Alejandro; Vera-Pineda, Raymundo; Flores-Ramirez, Ramiro. Institution Carrizales-Sepulveda, Edgar Francisco. Internal Medicine Department, Hospital Universitario, Universidad Autonoma de Nuevo Leon, Monterrey, Nuevo Leon, Mexico. Electronic address: [email protected]. Ordaz-Farias, Alejandro. Echocardiography Laboratory, Cardiology Service, Hospital Universitario, Universidad Autonoma de Nuevo Leon, Monterrey, Nuevo Leon, Mexico. Vera-Pineda, Raymundo. Internal Medicine Department, Hospital Universitario, Universidad Autonoma de Nuevo Leon, Monterrey, Nuevo Leon, Mexico. Flores-Ramirez, Ramiro. Internal Medicine Department, Hospital Universitario, Universidad Autonoma de Nuevo Leon, Monterrey, Nuevo Leon, Mexico; Echocardiography Laboratory, Cardiology Service, Hospital Universitario, Universidad Autonoma de Nuevo Leon, Monterrey, Nuevo Leon, Mexico. Abstract Periodontal and cardiovascular disease are both major health issues. Poor oral health has long been associated with the development of systemic diseases, with the typical example being the risk of endocarditis posterior to dental procedures. Through the years, the association of periodontal disease with other non-infectious systemic diseases has been brought to attention. One of the most interesting associations is the one that exists with the development of cardiovascular disease. Many studies, including systematic reviews and meta-analyses, suggest an important association between periodontal disease and ischaemic heart disease, cerebrovascular disease, heart failure, atrial fibrillation and peripheral artery disease. Among the proposed mechanisms of this relationship, systemic inflammation appears to play a major role. Evidence suggests that periodontal inflammation triggers a systemic inflammatory state that, added to the damage mediated by antibodies that cross react between periodontal pathogens and components of the intimal wall, and the direct lesion of the intima by bacteria entering the circulation, promotes atheroma plaque development and progression. There are other studies that show a clear relationship between periodontal disease severity, elevations of inflammatory markers, and the presence of atherosclerosis. Here, we give a review of the available evidence supporting this association, and the possible mechanisms involved. Copyright © 2018 Australian and New Zealand Society of Cardiac and Thoracic Surgeons (ANZSCTS) and the Cardiac Society of Australia and New Zealand (CSANZ). Published by Elsevier B.V. All rights reserved. Publication Type Journal Article. Review. Year of Publication 2018 <38> Unique Identifier 29937241 Title Relationship between bariatric surgery and periodontal status: a systematic review and meta-analysis. [Review] Source Surgery for Obesity & Related Diseases. 14(8):1205-1216, 2018 Aug. VI 1 Status In-Data-Review

Authors Maria de Souza G; Willya Douglas de Oliveira D; Santos Lages F; Andrade Fernandes I; Gabriel Moreira Falci S. Authors Full Name Maria de Souza, Glaciele; Willya Douglas de Oliveira, Dhelfeson; Santos Lages, Frederico; Andrade Fernandes, Ighor; Gabriel Moreira Falci, Saulo. Institution Maria de Souza, Glaciele. Department of Dentistry, Section of Oral and Maxillofacial Surgery, Federal University of Jequitinhonha e Mucuri Valleys, Diamantina, Brazil. Willya Douglas de Oliveira, Dhelfeson. Department of Dentistry, Section of Oral and Maxillofacial Surgery, Federal University of Jequitinhonha e Mucuri Valleys, Diamantina, Brazil; Department of Periodontology, Federal University of Minas Gerais, Belo Horizonte, Brazil. Santos Lages, Frederico. Department of Dental Prosthesis, University Center Newton Paiva, Belo Horizonte, Brazil. Andrade Fernandes, Ighor. Department of Dentistry, Section of Oral and Maxillofacial Surgery, Federal University of Jequitinhonha e Mucuri Valleys, Diamantina, Brazil. Gabriel Moreira Falci, Saulo. Department of Dentistry, Section of Oral and Maxillofacial Surgery, Federal University of Jequitinhonha e Mucuri Valleys, Diamantina, Brazil. Electronic address: [email protected]. Abstract BACKGROUND: The effects of bariatric surgery can reflect in the oral cavity and can cause alterations in oral health. This high prevalence of oral alterations in the pre and post-operative periods has been highlighted in different studies. OBJECTIVES: To investigate the effect of bariatric surgery on periodontal status through a systematic review. METHODS: Electronic search was conducted in PubMed, VHL, Web of Science, Science direct, Scopus, and Cochrane databases through May 2017. Manual search, gray literature, and counter-refence of included articles were also conducted. Eligibility criteria included observational studies that reported periodontal outcomes before and after bariatric surgery. RESULTS: Search strategy resulted in 1878 articles. Following the selection process, nine studies were included in the qualitative analysis and five in the meta-analysis. Three cross-sectional studies showed risk of bias score ranging from 5 to 6 stars, and Cohort studies scored from 6 to 9 stars out of 9 possible stars on the Newcastle-Ottawa scale. The quantitative analysis showed that clinical attachment level (MD: 0.07; CI95% -0.17 to 0.31), gingival index (MD: -0.28; CI95% -1.68 to 1.11), percentage of bleeding sites (MD: -0.21; CI95% -0.77 to 0.35), and pocket probing depth (MD: 0.08 CI95% -0.14 to 0.31) were not different before and after bariatric surgery. However, the plaque index was lower after than before bariatric surgery (MD: -1.29; CI 95% -2.34 to -0.24). CONCLUSIONS: Plaque index can be improved after bariatric surgery. The present systematic review investigated the association between bariatric surgery and periodontal status from cross-sectional and longitudinal studies. A systematic search strategy was developed until May 2017. The results of this systematic review allowed the conclusion that the plaque index can be improved after bariatric surgery. Copyright © 2018 American Society for Bariatric Surgery. Published by Elsevier Inc. All rights reserved. Publication Type Journal Article. Review. Year of Publication 2018 <39> Unique Identifier 30142580 Title Antagonistic effect of IL1 variants in periodontitis and external apical root resorption: Evidence from a literature review. [Review] Source Archives of Oral Biology. 95:195-201, 2018 Nov. VI 1 Status In-Process Authors Pereira SA; Melo A; Resende E; Regateiro F; Coimbra Silva H. Authors Full Name Pereira, Sonia Alves; Melo, Ana; Resende, Elisabete; Regateiro, Fernando; Coimbra Silva, Henriqueta. Institution Pereira, Sonia Alves. Department of Orthodontics, Faculty of Medicine, University of Coimbra, Av. Bissaya Barreto, Bloco de Celas, Coimbra 3000-075, Portugal. Electronic address: [email protected]. Melo, Ana. Department of Orthodontics, Faculty of Medicine, University of Coimbra, Av. Bissaya Barreto, Bloco de Celas, Coimbra 3000-075, Portugal. Electronic address: [email protected]. Resende, Elisabete. Medical Genetics Department, Faculty of Medicine, University of Coimbra, Av. Bissaya Barreto, Bloco de Celas, Coimbra 3000-075, Portugal. Electronic address: [email protected]. Regateiro, Fernando. Medical Genetics Department, Faculty of Medicine, University of Coimbra, Av. Bissaya Barreto, Bloco de Celas, Coimbra 3000-075, Portugal; CIMAGO (Center of Investigation on Environmental, Genetics and Oncobiology), Faculty of Medicine, University of Coimbra, Av. Bissaya Barreto, Bloco de Celas, Coimbra 3000-075, Portugal. Electronic address: [email protected]. Coimbra Silva, Henriqueta. Medical Genetics Department, Faculty of Medicine, University of Coimbra, Av. Bissaya Barreto, Bloco de Celas, Coimbra 3000-075, Portugal; CIMAGO (Center of Investigation on Environmental, Genetics and Oncobiology), Faculty of Medicine, University of Coimbra, Av. Bissaya Barreto, Bloco de Celas, Coimbra 3000-075, Portugal. Electronic address: [email protected]. Local Messages

THIS JOURNAL IS AVAILABLE IN THE BDA LIBRARY UP TO 2014, TO REQUEST THIS ARTICLE FROM THE LIBRARY GO TO: https://www.bda.org/library/journals-articles/Documents/photocopy-request-form.pdf Abstract External apical root resorption (EARR) induced by orthodontic treatment and chronic periodontitis (CP) are complex phenotypes dependent on the interaction of multiple genetic and non-genetic risk factors. Apart from different environmental triggers, these phenotypes are caused by antagonistic biological mechanisms involving local immunoinflammatory reaction and alveolar bone metabolism, for which IL1 have a prominent role. Whereas EARR benefits from bone remodelling, CP is characterized by osteolytic damaged. Our aim was to verify if these two phenotypes have opposite genetic profiles, considering the most frequently analysed polymorphisms for both diseases. A review of the literature was performed searching for the association of rs1800587 from Interleukin-1 alpha (IL1A) gene and rs1143634 from interleukin-1 beta (IL1B) gene with EARR and CP. The electronic search included MEDLINE/PubMed, EBSCOhost, Cochrane and Web of Science databases. Twenty four articles met the inclusion and exclusion criteria. For IL1B polymorphism, two out of seven studies found a significant statistical association between EARR and CC genotype, whether for CP, there were eighth out of fifteen references describing a statistically significant associations with T allele. For IL1A variant, no significant association with EARR was described. In conclusion, literature review suggests that for IL1B SNP rs1143634, EARR and CP have an opposite genetic profile. For IL1A SNP, our hypothesis could not be confirmed. Copyright © 2018 Elsevier Ltd. All rights reserved. Publication Type Journal Article. Review. Year of Publication 2018 <40> Unique Identifier 30024071 Title Contribution of herpesviruses in the progression of periodontal and peri-implant diseases in systemically healthy individuals. [Review] Source Reviews in Medical Virology. 28(5):e1996, 2018 09. VI 1 Status In-Process Authors Binshabaib M; ALHarthi SS; Salehpoor D; Michelogiannakis D; Javed F. Author NameID Javed, Fawad; ORCID: https://orcid.org/0000-0002-9253-1989 Authors Full Name Binshabaib, Munerah; ALHarthi, Shatha Subhi; Salehpoor, Danial; Michelogiannakis, Dimitrios; Javed, Fawad. Institution Binshabaib, Munerah. Department of Periodontology, College of Dentistry, Princess Nourah Bint Abdulrahman University, Riyadh, Saudi Arabia. ALHarthi, Shatha Subhi. Department of Periodontology, College of Dentistry, Princess Nourah Bint Abdulrahman University, Riyadh, Saudi Arabia. Salehpoor, Danial. Department of General Dentistry, Eastman Institute for Oral Health, University of Rochester, Rochester, New York, USA. Michelogiannakis, Dimitrios. Departments of Community Dentistry and Oral Disease Prevention and Orthodontics and Dentofacial Orthopedics, Eastman Institute for Oral Health, University of Rochester, Rochester, New York, USA. Javed, Fawad. Department of General Dentistry, Eastman Institute for Oral Health, University of Rochester, Rochester, New York, USA. Abstract The aim of this review was to assess the contribution of herpesviruses in the subgingival oral biofilm in the progression of periodontal and peri-implant diseases in systemically healthy individuals. The literature review was customized to summarize the pertinent information for the following reasons: (1) A systematic review regarding the role of herpesviruses in the etiopathogenesis of periodontal disease has recently been published; and (2) a limited number of studies have assessed the association of herpesviruses with peri-implant diseases. To date, five observational studies have assessed the presence of herpesviruses in the subgingival oral biofilm of individuals with peri-implant diseases. In these studies, dental implants were in place for up to approximately 8 years. In two studies, human cytomegalovirus (HCMV) was more often isolated from the peri-implant sulci of sites with than without peri-implantitis. In one study, a low prevalence of HCMV compared with Epstein-Barr virus (EBV) was associated with the progression of peri-implantitis. In previous studies, the presence of EBV in the subgingival oral biofilm was associated with the onset of peri-implantitis and peri-implant mucositis, respectively. Major limitations of the studies assessed were the absence of blinding and lack of power analysis for sample size estimation. In conclusion, the presence of herpesviruses in the periodontal and peri-implant subgingival oral biofilm is an indicator of periodontal and peri-implant diseases in systemically healthy individuals; however, further studies with a statistically justified sample-size are needed to understand and refine this association. Copyright © 2018 John Wiley & Sons, Ltd. Publication Type Journal Article. Review. Year of Publication 2018 <41> Unique Identifier 30086996 Title

Erratum to "Interrelation of periodontal parameters between asthmatics and nonasthmatics subjects: A systematic review and meta-analysis" [J. Dent. 69 (2018) 32-40].[Erratum for J Dent. 2018 Feb;69:32-40; PMID: 29203147] Source Journal of Dentistry. 77:112, 2018 Oct. VI 1 Status In-Data-Review Authors Mendes V; Dos Santos GO; Moraschini V. Authors Full Name Mendes, Vivian; Dos Santos, Gustavo Oliveira; Moraschini, Vittorio. Institution Mendes, Vivian. Department of Integrated Clinics, School of Dentistry, Fluminense Federal University, Niteroi, Rio de Janeiro, Brazil. Dos Santos, Gustavo Oliveira. Department of Integrated Clinics, School of Dentistry, Fluminense Federal University, Niteroi, Rio de Janeiro, Brazil. Moraschini, Vittorio. Department of Periodontology, School of Dentistry, Fluminense Federal University, Niteroi, Rio de Janeiro, Brazil. Electronic address: [email protected]. Local Messages THIS JOURNAL IS AVAILABLE IN THE BDA LIBRARY, BDA MEMBERS CAN ALSO ACCESS THIS JOURNAL ONLINE FROM 2011 TO DATE. Go to www.bda.org/ejournals Publication Type Published Erratum. Year of Publication 2018 <42> Unique Identifier 28875830 Title Is there an Association Between Periodontitis and Atherosclerosis in Adults? A Systematic Review. Source Current Vascular Pharmacology. 16(6):569-582, 2018. VI 1 Status In-Data-Review Authors Almeida APCPSC; Fagundes NCF; Maia LC; Lima RR. Authors Full Name Almeida, Anna P C P S C; Fagundes, Nathalia C F; Maia, Lucianne C; Lima, Rafael R. Institution Almeida, Anna P C P S C. Laboratory of Functional and Structural Biology, Institute of Biological Sciences, Federal University of Para, Belem, Brazil. Fagundes, Nathalia C F. Laboratory of Functional and Structural Biology, Institute of Biological Sciences, Federal University of Para, Belem, Brazil. Maia, Lucianne C. Department of Pediatric Dentistry and Orthodontics, School of Dentistry, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil. Lima, Rafael R. Laboratory of Functional and Structural Biology, Institute of Biological Sciences, Federal University of Para, Belem, Brazil. Abstract BACKGROUND: Atherosclerosis is a multifactorial inflammatory disease of the cardiovascular system. It has been suggested that periodontitis, an infectious disease of oral cavity caused by gramnegative anaerobic bacteria, could be linked to atherosclerosis. OBJECTIVE: The objective of this systematic review was to assess the evidence between the association of periodontitis and atherosclerosis in adults. METHODS: A systematic literature search was conducted in 7 databases up to January 2017, according to the Preferential Reports for Systematic Review and Meta-analysis (PRISMA) guidelines. Studies in humans with atherosclerosis were considered eligible when considering a group exposed to periodontitis and a control group (absence of periodontitis), in which the primary outcome was the association between the 2 diseases (atherosclerosis and periodontitis). The synthesis of the qualitative studies included was evaluated using previously validated checklist for assessing the risk of bias. RESULTS: Among the 2138 studies found, 4 observational studies met the eligibility criteria and were included in the qualitative synthesis. All articles were considered adequate, presenting consistent and valid information. The results of the selected studies show the expected effects, being considered as low risk of bias. CONCLUSION: The available evidence indicates an association between the 2 diseases, with elevated levels of inflammatory markers, mainly C-reactive protein and interleukin 6. Copyright© Bentham Science Publishers; For any queries, please email at [email protected]. Publication Type Journal Article. Year of Publication 2018

<43> Unique Identifier 30209331 Title Genome-wide association meta-analysis of coronary artery disease and periodontitis reveals a novel shared risk locus. Source Scientific Reports. 8(1):13678, 2018 Sep 12. VI 1 Status In-Data-Review Authors Munz M; Richter GM; Loos BG; Jepsen S; Divaris K; Offenbacher S; Teumer A; Holtfreter B; Kocher T; Bruckmann C; Jockel-Schneider Y; Graetz C; Munoz L; Bhandari A; Tennstedt S; Staufenbiel I; van der Velde N; Uitterlinden AG; de Groot LCPGM; Wellmann J; Berger K; Krone B; Hoffmann P; Laudes M; Lieb W; Franke A; Dommisch H; Erdmann J; Schaefer AS. Author NameID Munz, Matthias; ORCID: http://orcid.org/0000-0002-4728-3357 Divaris, Kimon; ORCID: http://orcid.org/0000-0003-1290-7251 Teumer, Alexander; ORCID: http://orcid.org/0000-0002-8309-094X Holtfreter, Birte; ORCID: http://orcid.org/0000-0002-6541-3127 de Groot, Lisette C P G M; ORCID: http://orcid.org/0000-0003-2778-2789 Hoffmann, Per; ORCID: http://orcid.org/0000-0002-6573-983X Franke, Andre; ORCID: http://orcid.org/0000-0003-1530-5811 Erdmann, Jeanette; ORCID: http://orcid.org/0000-0002-4486-6231 Schaefer, Arne S; ORCID: http://orcid.org/0000-0001-5816-6765 Authors Full Name Munz, Matthias; Richter, Gesa M; Loos, Bruno G; Jepsen, Soren; Divaris, Kimon; Offenbacher, Steven; Teumer, Alexander; Holtfreter, Birte; Kocher, Thomas; Bruckmann, Corinna; Jockel-Schneider, Yvonne; Graetz, Christian; Munoz, Loreto; Bhandari, Anita; Tennstedt, Stephanie; Staufenbiel, Ingmar; van der Velde, Nathalie; Uitterlinden, Andre G; de Groot, Lisette C P G M; Wellmann, Jurgen; Berger, Klaus; Krone, Bastian; Hoffmann, Per; Laudes, Matthias; Lieb, Wolfgang; Franke, Andre; Dommisch, Henrik; Erdmann, Jeanette; Schaefer, Arne S. Institution Munz, Matthias. Charite - University Medicine Berlin, corporate member of Freie Universitat Berlin, Humboldt-Universitat zu Berlin, and Berlin Institute of Health, Institute for Dental and Craniofacial Sciences, Department of Periodontology and Synoptic Dentistry, Berlin, Germany. Munz, Matthias. Institute for Cardiogenetics, University of Lubeck, 23562, Lubeck, Germany. Richter, Gesa M. Charite - University Medicine Berlin, corporate member of Freie Universitat Berlin, Humboldt-Universitat zu Berlin, and Berlin Institute of Health, Institute for Dental and Craniofacial Sciences, Department of Periodontology and Synoptic Dentistry, Berlin, Germany. Loos, Bruno G. Department of Periodontology and Oral Biochemistry, Academic Centre for Dentistry Amsterdam (ACTA), University of Amsterdam and Vrije Universiteit Amsterdam, Amsterdam, The Netherlands. Jepsen, Soren. Department of Periodontology, Operative and Preventive Dentistry, University of Bonn, Bonn, Germany. Divaris, Kimon. Department of Pediatric Dentistry, School of Dentistry, University of North Carolina at Chapel Hill, Chapel Hill, USA. Divaris, Kimon. Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, USA. Offenbacher, Steven. Department of Periodontology, School of Dentistry, University of North Carolina at Chapel Hill, Chapel Hill, USA. Teumer, Alexander. Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany. Holtfreter, Birte. Unit of Periodontology, Department of Restorative Dentistry, Periodontology, Endodontology, Preventive Dentistry and Pedodontics, Dental School, University Medicine Greifswald, Greifswald, Germany. Kocher, Thomas. Unit of Periodontology, Department of Restorative Dentistry, Periodontology, Endodontology, Preventive Dentistry and Pedodontics, Dental School, University Medicine Greifswald, Greifswald, Germany. Bruckmann, Corinna. Department of Conservative Dentistry and Periodontology, Medical University Vienna, School of Dentistry, Vienna, Austria. Jockel-Schneider, Yvonne. Department of Periodontology, Clinic of Preventive Dentistry and Periodontology, University Medical Center of the Julius-Maximilians-University, Wurzburg, Germany. Graetz, Christian. Department of Conservative Dentistry, Unit of Periodontology, University Medical Center Schleswig-Holstein, Campus Kiel, Germany. Munoz, Loreto. Institute for Cardiogenetics, University of Lubeck, 23562, Lubeck, Germany. Munoz, Loreto. DZHK (German Research Centre for Cardiovascular Research), partner site Hamburg/Lubeck/Kiel, Lubeck, 23562, Germany. Munoz, Loreto. University Heart Center Luebeck, 23562, Lubeck, Germany. Bhandari, Anita. Institute for Cardiogenetics, University of Lubeck, 23562, Lubeck, Germany. Bhandari, Anita. DZHK (German Research Centre for Cardiovascular Research), partner site Hamburg/Lubeck/Kiel, Lubeck, 23562, Germany. Bhandari, Anita. University Heart Center Luebeck, 23562, Lubeck, Germany. Tennstedt, Stephanie. Institute for Cardiogenetics, University of Lubeck, 23562, Lubeck, Germany. Tennstedt, Stephanie. DZHK (German Research Centre for Cardiovascular Research), partner site Hamburg/Lubeck/Kiel, Lubeck, 23562, Germany. Tennstedt, Stephanie. University Heart Center Luebeck, 23562, Lubeck, Germany. Staufenbiel, Ingmar. Department of Conservative Dentistry, Periodontology and Preventive Dentistry, Hannover Medical School, Hannover, Germany. van der Velde, Nathalie. Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands.

van der Velde, Nathalie. Department of Internal Medicine section of Geriatrics, Amsterdam Medical Center, Amsterdam, The Netherlands. Uitterlinden, Andre G. Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands. de Groot, Lisette C P G M. Wageningen University, Division of Human Nutrition, Wageningen, The Netherlands. Wellmann, Jurgen. Institute of Epidemiology and Social Medicine, University Munster, Munster, Germany. Berger, Klaus. Institute of Epidemiology and Social Medicine, University Munster, Munster, Germany. Krone, Bastian. Institute of Medical Informatics, Biometry and Epidemiology, University Clinic Essen, Essen, Germany. Hoffmann, Per. Institute of Human Genetics, University of Bonn, Bonn, Germany. Hoffmann, Per. Human Genomics Research Group, Department of Biomedicine, University Hospital of Basel, Basel, Switzerland. Laudes, Matthias. Department of Medicine 1, University of Kiel, Kiel, Germany. Lieb, Wolfgang. Institute of Epidemiology, Christian-Albrechts-University, Kiel, Germany. Franke, Andre. Institute of Epidemiology, Christian-Albrechts-University, Kiel, Germany. Dommisch, Henrik. Charite - University Medicine Berlin, corporate member of Freie Universitat Berlin, Humboldt-Universitat zu Berlin, and Berlin Institute of Health, Institute for Dental and Craniofacial Sciences, Department of Periodontology and Synoptic Dentistry, Berlin, Germany. Erdmann, Jeanette. Institute for Cardiogenetics, University of Lubeck, 23562, Lubeck, Germany. Erdmann, Jeanette. DZHK (German Research Centre for Cardiovascular Research), partner site Hamburg/Lubeck/Kiel, Lubeck, 23562, Germany. Erdmann, Jeanette. University Heart Center Luebeck, 23562, Lubeck, Germany. Schaefer, Arne S. Charite - University Medicine Berlin, corporate member of Freie Universitat Berlin, Humboldt-Universitat zu Berlin, and Berlin Institute of Health, Institute for Dental and Craniofacial Sciences, Department of Periodontology and Synoptic Dentistry, Berlin, Germany. [email protected]. Abstract Evidence for a shared genetic basis of association between coronary artery disease (CAD) and periodontitis (PD) exists. To explore the joint genetic basis, we performed a GWAS meta-analysis. In the discovery stage, we used a German aggressive periodontitis sample (AgP-Ger; 680 cases vs 3,973 controls) and the CARDIoGRAMplusC4D CAD meta-analysis dataset (60,801 cases vs 123,504 controls). Two SNPs at the known CAD risk loci ADAMTS7 (rs11634042) and VAMP8 (rs1561198) passed the pre-assigned selection criteria (PAgP-Ger < 0.05; PCAD < 5 x 10-8; concordant effect direction) and were replicated in an independent GWAS meta-analysis dataset of PD (4,415 cases vs 5,935 controls). SNP rs1561198 showed significant association (PD[Replication]: P = 0.008 OR = 1.09, 95% CI = [1.02-1.16]; PD [Discovery + Replication]: P = 0.0002, OR = 1.11, 95% CI = [1.05-1.17]). For the associated haplotype block, allele specific cis-effects on VAMP8 expression were reported. Our data adds to the shared genetic basis of CAD and PD and indicate that the observed association of the two disease conditions cannot be solely explained by shared environmental risk factors. We conclude that the molecular pathway shared by CAD and PD involves VAMP8 function, which has a role in membrane vesicular trafficking, and is manipulated by pathogens to corrupt host immune defense. Publication Type Journal Article. Year of Publication 2018 <44> Unique Identifier 29938619 Title A Proteomic Analysis of the Virulence Factors of Three Common Bacterial Species Involved in Periodontitis and Consequent Possible Atherosclerosis: A Narrative Review. Source Current Protein & Peptide Science. 19(11):1124-1130, 2018. VI 1 Status In-Process Authors Mirnejad R; Razeghian-Jahromi I; Sepehrimanesh M; Zibaeenezhad MJ; Lopez-Jornet P. Authors Full Name Mirnejad, Reza; Razeghian-Jahromi, Iman; Sepehrimanesh, Masood; Zibaeenezhad, Mohammad Javad; Lopez-Jornet, Pia. Institution Mirnejad, Reza. Molecular Biology Research Center, Systems Biology and Poisoning Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran. Razeghian-Jahromi, Iman. Cardiovascular Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. Sepehrimanesh, Masood. Gastrointestinal and Liver Diseases Research Center, Guilan University of Medical Sciences, Rasht, Iran. Zibaeenezhad, Mohammad Javad. Cardiovascular Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. Lopez-Jornet, Pia. Faculty of Medicine and Dentistry, University of Murcia, Murcia, Spain. Abstract The incidence of cardiovascular disorders, especially coronary artery disease and atherosclerosis, is increasing alarmingly. Clarifying the underlying causes is of the utmost importance and should be elucidated in order to reduce this growing trend. Periodontitis is known as a chronic destructive disease with sophisticated pathophysiological mechanisms that slowly impose negative effects not only on the oral tissues but also on distant organs. Additionally, it has been shown in many studies that atherosclerosis and periodontitis utilized common inflammatory signaling pathways and mediators. Several lines of evidence have demonstrated the signatures of periodontitis-related bacteria in atherosclerotic plaque specimens. It is proposed that virulent proteins of these bacteria probably accelerate the initiation or development of plaque formation on the inner walls of the coronary arteries. Proteomics techniques are very sensitive and have a global point of view. They can help to discover host factors and pathogenrelated biomarkers. This review summarizes the studies focused on the three most important bacterial species involved

in both diseases and presents recent findings about the proteomic evaluation of virulence factors of these bacteria. The known mechanisms of action of the virulence factors are also described. Copyright© Bentham Science Publishers; For any queries, please email at [email protected]. Publication Type Journal Article. Year of Publication 2018 <45> Unique Identifier 30197691 Title The Periodontium as a Potential Cause of Orofacial Pain: A Comprehensive Review. [Review] Source The open dentistry journal. 12:520-528, 2018. VI 1 Status PubMed-not-MEDLINE Authors Miranda-Rius J; Brunet-Llobet L; Lahor-Soler E. Authors Full Name Miranda-Rius, Jaume; Brunet-Llobet, Lluis; Lahor-Soler, Eduard. Institution Miranda-Rius, Jaume. Department of Odontostomatology, Faculty of Medicine and Health Sciences, Universitat de Barcelona, Barcelona, Spain. Miranda-Rius, Jaume. Hospital Dentistry & Periodontal Medicine Research Group, Institut de Recerca Sant Joan de Deu (IRSJD), Fundacio Sant Joan de Deu, Barcelona, Spain. Brunet-Llobet, Lluis. Division of Orthodontics and Pediatric Dentistry, Hospital Sant Joan de Deu, Universitat de Barcelona, Barcelona, Spain. Brunet-Llobet, Lluis. Hospital Dentistry & Periodontal Medicine Research Group, Institut de Recerca Sant Joan de Deu (IRSJD), Fundacio Sant Joan de Deu, Barcelona, Spain. Lahor-Soler, Eduard. Department of Odontostomatology, Faculty of Medicine and Health Sciences, Universitat de Barcelona, Barcelona, Spain. Lahor-Soler, Eduard. Hospital Dentistry & Periodontal Medicine Research Group, Institut de Recerca Sant Joan de Deu (IRSJD), Fundacio Sant Joan de Deu, Barcelona, Spain. Abstract Introduction: Orofacial pain of periodontal origin has a wide range of causes, and its high prevalence and negative effect on patients' quality of life make intervention mandatory. This review provides a periodontological overview of the field of orofacial pain, focusing on the entities which involve the periodontal tissues and may be the cause of this pain or discomfort. Methods: The study comprised a literature search of these pathologies conducted in the MEDLINE/PubMed Database. Acute infectious entities such as gingival and periodontal abscesses are emergencies that require a rapid response. Periodontitis associated with endodontic processes, necrotizing periodontal disorders, desquamative gingivitis, gingival recession, and mucogingival herpetic lesions, cause mild to severe pain due to tissue destruction and loss. Other lesions that lead to periodontal discomfort include gingival enlargement and periodontal ligament strains associated with occlusal trauma, parafunctional habit and the impaction of food or foreign bodies. Conclusion: A range of therapeutic, pharmacological and surgical alternatives are available for the management of these injuries. However, the wide variety of causes of orofacial pain or periodontal discomfort may confuse the clinician during diagnosis and may lead to the wrong choice of treatment. Publication Type Journal Article. Review. Year of Publication 2018 <46> Unique Identifier 29858878 Title Serum vitamin D levels and chronic periodontitis in adult, Caucasian population-a systematic review. [Review] Source Journal of Periodontal Research. 53(5):645-656, 2018 Oct. VI 1 Status In-Process Authors Peric M; Cavalier E; Toma S; Lasserre JF. Author NameID Peric, M; ORCID: http://orcid.org/0000-0002-9817-816X Authors Full Name Peric, M; Cavalier, E; Toma, S; Lasserre, J F. Institution Peric, M. Department of Periodontology, Saint Luc University Hospital, Universite Catholique de Louvain (UCL), Brussels, Belgium.

Cavalier, E. Department of Clinical Chemistry, CHU Sart-Tilman, University of Liege, Liege, Belgium. Toma, S. Department of Periodontology, Saint Luc University Hospital, Universite Catholique de Louvain (UCL), Brussels, Belgium. Lasserre, J F. Department of Periodontology, Saint Luc University Hospital, Universite Catholique de Louvain (UCL), Brussels, Belgium. Local Messages THIS JOURNAL IS AVAILABLE IN THE BDA LIBRARY, TO REQUEST THIS ARTICLE FROM THE LIBRARY GO TO: https://www.bda.org/library/journals-articles/Documents/photocopy-request-form.pdf Abstract The aim of this systematic review was to explore the relationship between serum vitamin D levels and periodontal disease. The review followed Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. The focused PICO question was: Are serum vitamin D levels (I) associated with gingivitis or periodontitis (C) in healthy humans (P)? PubMed (Medline), Embase, Science Direct, the Cochrane library, and grey literature were searched up to 31 July 2017. Two reviewers independently selected studies and extracted data. Quality, risk of bias, and heterogeneity of the studies were assessed using the Newcastle-Ottawa Scale. In total, 365 studies were identified and 24 were analyzed. Seven studies fulfilled the inclusion criteria. Four case-control studies showed an influence of vitamin D and its metabolites on periodontal health status/disease. One interventional study suggested the proposed anti-inflammatory role of vitamin D. Two cross-sectional studies failed to show a relationship between vitamin D and periodontal condition. The literature on the effect of serum vitamin D levels on periodontal status remains scarce and controversial. Some data, however, support a "perio-protective" role for vitamin D. There is a need for well-designed randomized clinical trials to explore the possible anti-inflammatory effect of vitamin D on periodontal health. Copyright © 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. Publication Type Journal Article. Review. Year of Publication 2018 <47> Unique Identifier 29777531 Title The directional and non-directional associations of periodontitis with chronic kidney disease: A systematic review and meta-analysis of observational studies. [Review] Source Journal of Periodontal Research. 53(5):682-704, 2018 Oct. VI 1 Status In-Process Authors Zhao D; Khawaja AT; Jin L; Li KY; Tonetti M; Pelekos G. Author NameID Zhao, D; ORCID: http://orcid.org/0000-0002-0037-1464 Pelekos, G; ORCID: http://orcid.org/0000-0003-1917-1988 Authors Full Name Zhao, D; Khawaja, A T; Jin, L; Li, K-Y; Tonetti, M; Pelekos, G. Institution Zhao, D. Faculty of Dentistry, The University of Hong Kong, Hong Kong SAR, China. Khawaja, A T. Faculty of Dentistry, The University of Hong Kong, Hong Kong SAR, China. Jin, L. Faculty of Dentistry, The University of Hong Kong, Hong Kong SAR, China. Li, K-Y. Faculty of Dentistry, The University of Hong Kong, Hong Kong SAR, China. Tonetti, M. Faculty of Dentistry, The University of Hong Kong, Hong Kong SAR, China. Pelekos, G. Faculty of Dentistry, The University of Hong Kong, Hong Kong SAR, China. Local Messages THIS JOURNAL IS AVAILABLE IN THE BDA LIBRARY, TO REQUEST THIS ARTICLE FROM THE LIBRARY GO TO: https://www.bda.org/library/journals-articles/Documents/photocopy-request-form.pdf Abstract This systematic review aimed to assess the current evidence on the directional and non-directional associations of periodontitis with chronic kidney disease (CKD). Electronic search for observational studies on the association of periodontitis with CKD was performed in MEDLINE, EMBASE, PubMed, Open GREY and Cochrane library up to June 5, 2017. Two reviewers conducted study selection, data collection and assessment of methodological quality using the original and modified Newcastle-Ottawa Scale. Cohort, case-control and cross-sectional studies were included, which clearly defined periodontitis and CKD or reported acceptable clinical parameters of these 2 diseases in adults. Meta-analysis was employed to estimate the pooled odds ratio on the non-directional association and the incidence rate ratio (IRR) for the directional association. Among 2530 potential eligible articles, 47 were finally included. Most of them investigated a non-directional association of periodontitis with CKD, including 7 case-control studies and 38 cross-sectional studies; 24 studies had statistical analysis on the non-directional association and 75% of them reported significant results, which were supported further by the meta-analysis (random: odds ratio = 2.12, P < .001; chi2 = 25.74, I2 = 88.3%). None of the studies focused on the directional association of CKD (as the exposure) with periodontitis (as the outcome), whereas 2 retrospective cohort studies explored a directional association of periodontitis (as the exposure) with CKD (as the outcome) (random: IRR=2.10, P > .05; fixed: IRR=1.76, P < .05; chi2 = 4.65, I2 = 78.3%). Overall, the high heterogeneity of studies limits the significance of these results. There is substantial evidence on the non-directional association of periodontitis with CKD, while there are limited studies on the directional association. Well-designed prospective studies with longer follow-ups in representative communities are needed to clarify the directional association and enhance the quality of the evidence on this topic. Copyright © 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Publication Type Journal Article. Review. Year of Publication 2018 <48> Unique Identifier 30198136 Title Periodontal complications with obesity. [Review] Source Periodontology 2000. 78(1):98-128, 2018 Oct. VI 1 Status In-Data-Review Authors Suvan JE; Finer N; D'Aiuto F. Authors Full Name Suvan, Jean E; Finer, Nicholas; D'Aiuto, Francesco. Institution Suvan, Jean E. Unit of Periodontology, UCL Eastman Dental Institute, London, UK. Finer, Nicholas. National Centre for Cardiovascular Prevention and Outcomes, UCL Institute of Cardiovascular Science, London, UK. D'Aiuto, Francesco. Unit of Periodontology, UCL Eastman Dental Institute, London, UK. Local Messages THIS JOURNAL IS AVAILABLE IN THE BDA LIBRARY, TO REQUEST THIS ARTICLE FROM THE LIBRARY GO TO: https://www.bda.org/library/journals-articles/Documents/photocopy-request-form.pdf Abstract The purpose of this paper was to identify and summarize current evidence describing periodontal complications associated with obesity. Electronic searches supplemented with manual searches were carried out to identify relevant systematic reviews. Identification, screening, eligibility, and inclusion of studies were performed independently by two reviewers. A MeaSurement Tool to Assess systematic Reviews (AMSTAR) was used to assess the quality and risk of bias of the included reviews. From 430 titles and abstracts screened, 14 systematic reviews were considered as eligible for inclusion in this meta-review. Eight reviews reported on cross-sectional studies investigating the association of obesity and periodontal diseases, 4 included longitudinal studies, 5 addressed response to periodontal therapy, 5 reported on studies investigating biomarkers, and only 2 were related to pediatric population samples. Systematic review summaries in the various study design domains (cross-sectional, longitudinal and experimental) report that obese individuals are more likely to have periodontal diseases, with more severe periodontal conditions, than nonobese individuals, with cross-sectional evidence congruent with longitudinal studies showing that obesity or weight gain increases the risk of periodontitis onset and progression. Published research on the effect of obesity on responses to periodontal therapy, or systemic or local biomarkers of inflammation, is variable and therefore inconclusive based on the evidence currently available, which suggests that overweight/obesity contributes to periodontal complications independently of other risk factors, such as age, gender, smoking, or ethnicity. This evidence supports the need for risk assessments for individual patients to facilitate personalized approaches in order to prevent and treat periodontal diseases. Copyright © 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. Publication Type Journal Article. Review. Year of Publication 2018 <49> Unique Identifier 30198134 Title Periodontal complications of hyperglycemia/diabetes mellitus: Epidemiologic complexity and clinical challenge. [Review] Source Periodontology 2000. 78(1):59-97, 2018 Oct. VI 1 Status In-Data-Review Authors Kocher T; Konig J; Borgnakke WS; Pink C; Meisel P. Authors Full Name Kocher, Thomas; Konig, Jorgen; Borgnakke, Wenche Sylling; Pink, Christiane; Meisel, Peter. Institution Kocher, Thomas. Department of Restorative Dentistry, Periodontology, Endodontology, and Preventive and Pediatric Dentistry, University Medicine Greifswald, Greifswald, Germany. Konig, Jorgen. Department of Restorative Dentistry, Periodontology, Endodontology, and Preventive and Pediatric Dentistry, University Medicine Greifswald, Greifswald, Germany. Borgnakke, Wenche Sylling. Department of Periodontics and Oral Medicine, University of Michigan School of Dentistry, Ann Arbor, Michigan. Pink, Christiane. Department of Restorative Dentistry, Periodontology, Endodontology, and Preventive and Pediatric Dentistry, University Medicine Greifswald, Greifswald, Germany. Meisel, Peter. Department of Restorative Dentistry, Periodontology, Endodontology, and Preventive and Pediatric Dentistry, University Medicine Greifswald, Greifswald, Germany.

Local Messages THIS JOURNAL IS AVAILABLE IN THE BDA LIBRARY, TO REQUEST THIS ARTICLE FROM THE LIBRARY GO TO: https://www.bda.org/library/journals-articles/Documents/photocopy-request-form.pdf Abstract This report provides a comprehensive overview of the adverse effects of hyperglycemia on the periodontium. It combines data from literature reviews of original data from two large, population-based epidemiologic studies with comprehensive periodontal health assessment. Emphasis is placed on the exploration of hitherto sparsely reported effects of prediabetes and poorly controlled (uncontrolled) diabetes, in contrast to the umbrella term "diabetes." This stems from the realization that it is not simply having a diagnosis of diabetes that may adversely affect periodontal health. Rather, it is the level (severity) of hyperglycemia that is the determining factor, not the case definition of the diagnosis of diabetes or the type of diabetes in question. Importantly, based on existing evidence this paper also attempts to estimate the improvements in periodontal probing depth and clinical attachment level that can be expected upon successful nonsurgical periodontal treatment in people with chronic periodontitis, with and without diabetes, respectively. This exploration includes the implentation of new systematic reviews and meta-analyses that allow comparison of such intervention outcomes between hyperglycemic and normoglycemic subjects. Based on both existing literature and original analyses of population-based studies, we try to answer questions such as: Is there a glycated hemoglobin concentration threshold for periodontitis risk? Does short-term periodontal probing depth reduction and clinical attachment level gain after scaling and root planing depend on glycemic control in type 2 diabetes? Are short-term scaling and root planing outcomes in people with hyperglycemia/diabetes inferior to those in people without diabetes? Do periodontitis patients with diabetes benefit more from the use of adjuvant antibiotics with nonsurgical periodontal treatment than people without diabetes? Does hyperglycemia lead to greater tooth loss in patients in long-term post-periodontal treatment maintenance programs? Throughout this review, we compare our new findings with previous data and report whether the results of these new analyses corroborate, or are in discord with, similar scientific reports in the literature. We also explore the potential role of dental health-care professionals in helping patients control the risk factors that are identical for periodontitis and diabetes. Finally, we suggest various topics that still need exploration in future research. Copyright © 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. Publication Type Journal Article. Review. Year of Publication 2018 <50> Unique Identifier 30198131 Title Behavioral models for periodontal health and disease. [Review] Source Periodontology 2000. 78(1):201-211, 2018 Oct. VI 1 Status In-Data-Review Authors Newton JT; Asimakopoulou K. Authors Full Name Newton, Jonathon T; Asimakopoulou, Koula. Institution Newton, Jonathon T. Unit of Social and Behavioural Sciences, Population & Patient Health, King's College London, Guy's Hospital, London, UK. Asimakopoulou, Koula. Unit of Social and Behavioural Sciences, Population & Patient Health, King's College London, Guy's Hospital, London, UK. Local Messages THIS JOURNAL IS AVAILABLE IN THE BDA LIBRARY, TO REQUEST THIS ARTICLE FROM THE LIBRARY GO TO: https://www.bda.org/library/journals-articles/Documents/photocopy-request-form.pdf Abstract The oral health-related behavior of patients with periodontal disease is a critical determinant of their health. Psychological models of behavior provide a framework for the design of interventions to enhance oral health-related behavior. This article reviews published manuscripts on interventions to enhance oral health-related behavior, classifying the nature of the interventions according to current psychological models of behavior. Fifteen manuscripts reporting the findings of 14 studies were identified and reviewed. The present article concludes that, based on current evidence, the key elements of effective interventions are: goal setting, planning the behavior change, and self-monitoring. Copyright © 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. Publication Type Journal Article. Review. Year of Publication 2018 <51> Unique Identifier 29604177 Title Systematic review and meta-analysis of double-blind, placebo-controlled, randomized clinical trials using probiotics in chronic periodontitis. Source Journal of Investigative & Clinical Dentistry. 9(3):e12338, 2018 Aug.

VI 1 Status In-Process Authors Ikram S; Hassan N; Raffat MA; Mirza S; Akram Z. Author NameID Akram, Zohaib; ORCID: http://orcid.org/0000-0001-9618-8818 Authors Full Name Ikram, Sana; Hassan, Nuzhat; Raffat, Muhammad A; Mirza, Sana; Akram, Zohaib. Institution Ikram, Sana. Department of Oral Biology, Faculty of Dentistry, Ziauddin University, Karachi, Pakistan. Hassan, Nuzhat. Department of Anatomy, Faculty of Basic Health Sciences, Ziauddin University, Karachi, Pakistan. Raffat, Muhammad A. Department of Oral Pathology, Faculty of Dentistry, Ziauddin University, Karachi, Pakistan. Mirza, Sana. Department of Oral Pathology, Faculty of Dentistry, Ziauddin University, Karachi, Pakistan. Akram, Zohaib. Department of Periodontology, Faculty of Dentistry, Ziauddin University, Karachi, Pakistan. Abstract AIM: The aim of the present study was to evaluate the efficacy of probiotics as an adjunct to scaling and root planning (SRP) in the treatment of chronic periodontitis (CP). METHODS: The focused question of the study was: Does adjunctive use of probiotics yield better clinical periodontal outcomes compared to placebo/no treatment group in the treatment of CP? Electronic and manual literature searches were conducted up to December 2017 using the following databases: MEDLINE, EMBASE, Cochrane Central Register of Controlled Trials, and Cochrane Oral Health Group Trials Register. Forest plots were computed reporting weighted mean difference (WMD) of outcomes and 95% confidence intervals (CI). RESULTS: Seven clinical studies were included. Four studies showed additional benefits in reducing periodontal probing depth (PPD) and gaining clinical attachment level (CAL), whereas, three studies showed comparable clinical periodontal outcomes between probiotics and SRP/placebo. Significant heterogeneity was observed for PPD reduction and CAL gain. The overall mean difference for CAL gain between probiotics and placebo/SRP was significant (WMD = 1.41, 95% CI = 0.15-2.67, P = .028) at follow up. CONCLUSION: Adjunctive probiotics could result in additional benefits in CAL gain in CP. Nevertheless, further high-quality randomized clinical trials with microbiological outcomes are warranted to obtain strong conclusions in this regard. Copyright © 2018 John Wiley & Sons Australia, Ltd. Publication Type Journal Article. Year of Publication 2018 <52> Unique Identifier 29450974 Title Effect of scaling and root planing on gingival crevicular fluid cytokine/chemokine levels in smokers with chronic periodontitis: A systematic review. [Review] Source Journal of Investigative & Clinical Dentistry. 9(3):e12327, 2018 Aug. VI 1 Status In-Process Authors Eshghipour B; Tofighi H; Nehal F; Vohra F; Javed F; Akram Z. Author NameID Akram, Zohaib; ORCID: http://orcid.org/0000-0001-9618-8818 Authors Full Name Eshghipour, Baharak; Tofighi, Hamid; Nehal, Faham; Vohra, Fahim; Javed, Fawad; Akram, Zohaib. Institution Eshghipour, Baharak. Department of Dentistry, Tehran University of Medical Sciences and Health Services, Tehran, Iran. Eshghipour, Baharak. Department of Public Health, Eastman Institute for Oral Health, University of Rochester, Rochester, NY, USA. Tofighi, Hamid. Department of Pediatric Dentistry, Eastman Institute for Oral Health, University of Rochester, Rochester, NY, USA. Nehal, Faham. Department of Endodontics, Liaquat College of Medicine and Dentistry, Karachi, Pakistan. Vohra, Fahim. Department of Prosthetic Dental Sciences, College of Dentistry, King Saud University, Riyadh, Saudi Arabia. Javed, Fawad. Department of General Dentistry, Eastman Institute for Oral Health, University of Rochester, Rochester, NY, USA. Akram, Zohaib. Department of Periodontology, Faculty of Dentistry, Ziauddin University, Karachi, Pakistan. Abstract In the present study, the impact of scaling and root planing (SRP) on gingival crevicular fluid (GCF) cytokine/chemokine levels in smokers with chronic periodontitis was assessed. The PICO (population, intervention, comparison, outcome) question was: In smokers with chronic periodontitis (population), what is the effect of SRP (intervention) in comparison to SRP in non-smokers with chronic periodontitis (comparison) on the GCF cytokine/chemokine level (outcome)? Indexed databases were searched up to September 2017. Of 4330 titles, nine studies reporting the levels of 13 different cytokines/chemokines were included. Eight studies had a moderate risk of bias, while one study had a high risk of bias. Almost all cytokines/chemokines were pro-inflammatory

cytokines. Five cytokines/chemokines studied in four clinical studies were decreased in the smoker-chronic periodontitis group following SRP. One study observed that the GCF levels of interleukin-17 increased, while anti-inflammatory osteoprotegerin was reduced in both the SCP and non-smoker-chronic periodontitis groups at follow up. However, the majority of cytokines/chemokines did not change in the SCP groups at follow up. The current weight of evidence is not sufficient to prove that SRP has an impact on GCF cytokine/chemokine profile in smokers with chronic periodontitis. Evaluation of wide panels of pro-inflammatory cytokines/chemokines related to collagen degradation and alveolar bone destruction in future studies are warranted. Copyright © 2018 John Wiley & Sons Australia, Ltd. Publication Type Journal Article. Review. Year of Publication 2018 <53> Unique Identifier 29974484 Title Periodontal disease and susceptibility to breast cancer: A meta-analysis of observational studies. [Review] Source Journal of Clinical Periodontology. 45(9):1025-1033, 2018 Sep. VI 1 Status In-Data-Review Authors Shi T; Min M; Sun C; Zhang Y; Liang M; Sun Y. Author NameID Sun, Yehuan; ORCID: http://orcid.org/0000-0002-8651-8059 Authors Full Name Shi, Tingting; Min, Min; Sun, Chenyu; Zhang, Yun; Liang, Mingming; Sun, Yehuan. Institution Shi, Tingting. Department of Epidemiology and Health Statistics, School of Public Health, Anhui Medical University, Hefei, Anhui, China. Min, Min. Department of Epidemiology and Health Statistics, School of Public Health, Anhui Medical University, Hefei, Anhui, China. Sun, Chenyu. The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China. Zhang, Yun. Department of Epidemiology and Health Statistics, School of Public Health, Anhui Medical University, Hefei, Anhui, China. Liang, Mingming. Department of Epidemiology and Health Statistics, School of Public Health, Anhui Medical University, Hefei, Anhui, China. Sun, Yehuan. Department of Epidemiology and Health Statistics, School of Public Health, Anhui Medical University, Hefei, Anhui, China. Sun, Yehuan. Center for Evidence-Based Practice, Anhui Medical University, Hefei, Anhui, China. Local Messages THIS JOURNAL IS AVAILABLE IN THE BDA LIBRARY, TO REQUEST THIS ARTICLE FROM THE LIBRARY GO TO: https://www.bda.org/library/journals-articles/Documents/photocopy-request-form.pdf Abstract OBJECTIVE: While some individual studies have suggested an association between periodontal disease and breast cancer, there has not been a formal meta-analysis that collates the existing evidence supporting the hypothesis that periodontal disease leads to a higher risk of developing breast cancer. Accordingly, this meta-analysis was conducted. METHODS: Relevant studies published until April 2018 were retrieved and were screened according to established inclusion criteria. Risk ratios (RRs) with 95% confidence intervals (CIs) were calculated to assess the association between periodontal disease and the risk of breast cancer and fixed effect models were used according to the results of the heterogeneity test. RESULTS: Eight studies, involving 168,111 individuals, were identified as having explored the association between periodontal disease and breast cancer. Summary estimates in view of adjusted data showed that periodontal disease did increase susceptibility to breast cancer (RR = 1.18, 95%CI: 1.11-1.26, I2 = 17.6%), with robust results confirmed by sensitivity analysis. CONCLUSION: Our results provided evidence of a modest positive association between periodontal disease and breast cancer. Implementation of practical measures to prevent and treat periodontal disease is of great public health significance. Moreover, additional studies are recommended to explore this topic in more detail. Copyright © 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. Publication Type Journal Article. Review. Year of Publication 2018 <54> Unique Identifier 30175194 Title Prevalence of Anaerobic Bacteria (P.gingivalis) as Major Microbial Agent in the Incidence Periodontal Diseases by Meta-analysis. Source

Journal of Dentistry. 19(3):232-242, 2018 Sep. VI 1 Status PubMed-not-MEDLINE Authors Rafiei M; Kiani F; Sayehmiri K; Sayehmiri F; Tavirani M; Dousti M; Sheikhi A. Authors Full Name Rafiei, Mohammad; Kiani, Faezeh; Sayehmiri, Kourosh; Sayehmiri, Fatemeh; Tavirani, Mostafa; Dousti, Majid; Sheikhi, Abdolkarim. Institution Rafiei, Mohammad. Dept. of Biostatistics and Epidemiology, Arak University of Medical Sciences, Arak, Iran. Kiani, Faezeh. Student Research Committee, Ilam University of Medical Sciences, Ilam, Iran. Sayehmiri, Kourosh. Dept. of Social Medicine, Dept. of Biostatistics, School of Medicine, Ilam University of Medical Sciences, Ilam, Iran. Sayehmiri, Fatemeh. Proteomics Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Tavirani, Mostafa. Proteomics Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Dousti, Majid. Dept. of Parasitology, School of Medicine, Shiraz University of Medical Sciences, Fars, Iran. Sheikhi, Abdolkarim. Dept. of Immunology, School of Medicine, Dezful University of Medical Sciences, Dezful, Khuzestan, Iran. Abstract Statement of the Problem: Periodontal diseases are complex oral diseases characterized by bacterial-induced inflammatory destruction of tooth-supporting tissues. Porphyromonas gingivalis (P. gingivalis) is a common gram-negative anaerobic oral bacteria strongly associated with periodontal disease. Purpose: The present study was conducted to estimate prevalence of P. gingivalis in patients with periodontal diseases by using meta-analysis method. Martials and Method: Different databases including PubMed, EmBase, Scopus, the Institute for Scientific Information (ISI) Web of Science, and the Cochrane Library were searched to identify original English-language studies addressing prevalence of P. gingivalis in periodontal diseases up to December 2014. The random effects model was applied in the meta-analysis and the heterogeneity between studies was assessed using a Cochran test and the I2 index. Funnel plots and Egger test were used to examine publication bias. Statistical analyses were performed using STATA version 12. Results: Forty-two eligible studies published during 1993- 2016 were selected for meta-analysis. Considering all the included studies, the total sample size was 5,884 individuals containing 2,576 healthy people with a mean age of 37.21+/-7.45 years and 3,308 periodontal patients with a mean age of 44.16+/-8.35 years. Overall, the prevalence of P. gingivalis was 78% [95% CI: 74-81] in periodontal diseases group and 34% [95% CI: 26-41] in healthy individuals. There was a significantly higher prevalence of P.gingivalis in individuals with periodontal diseases compared to healthy subjects [78% versus 34%, respectively]. Conclusion: This study indicates that P. gingivalis is highly present in subjects with periodontal diseases and it also appears in periodontally healthy people, although to a lesser extent. Thus, the presence of P. gingivalis increases the chance of periodontal disease and it can be considered as a main potential risk factor. Publication Type Journal Article. Year of Publication 2018 <55> Unique Identifier 30133749 Title Antimicrobial photodynamic therapy for the treatment of periodontitis and peri-implantitis: An American Academy of Periodontology best evidence review. Source Journal of Periodontology. 89(7):783-803, 2018 Jul. VI 1 Status In-Data-Review Authors Chambrone L; Wang HL; Romanos GE. Authors Full Name Chambrone, Leandro; Wang, Hom-Lay; Romanos, Georgios E. Institution Chambrone, Leandro. School of Dentistry, Ibirapuera University (Unib), Sao Paulo, Brazil. Chambrone, Leandro. Unit of Basic Oral Investigation (UIBO), School of Dentistry, El Bosque University, Bogota, Colombia. Wang, Hom-Lay. Department of Periodontics and Oral Medicine, School of Dentistry, University of Michigan, Ann Arbor, MI. Romanos, Georgios E. Department of Periodontology, School of Dental Medicine, Stony Brook University, Stony Brook, NY. Local Messages THIS JOURNAL IS AVAILABLE IN THE BDA LIBRARY, TO REQUEST THIS ARTICLE FROM THE LIBRARY GO TO: https://www.bda.org/library/journals-articles/Documents/photocopy-request-form.pdf Abstract BACKGROUND: This systematic review evaluates the efficacy of antimicrobial photodynamic therapy (aPDT), as an adjunct to non-surgical or surgical therapy, on clinical and patient-centered outcomes in patients with periodontitis or peri-implantitis. METHODS: Randomized controlled trials (RCTs) with a follow-up duration >= 3 months that evaluated mechanical root/implant surface debridement (i.e., scaling and root planing [SRP] or implant surface scaling [ISS]) versus SRP or ISS plus aPDT for the

treatment of adult patients (>= 18 years old) with moderate-to-severe chronic (CP)/aggressive periodontitis (AgP) or peri-implantitis, respectively, were considered eligible for inclusion. The MEDLINE, EMBASE, and CENTRAL databases were searched for articles published up to and including March 2017. Random-effects meta-analyses were used throughout the review using continuous data (i.e., mean changes from baseline), and pooled estimates were expressed as weighted mean differences with their associated 95% confidence intervals. Additionally, summaries are presented of the included RCTs, critical remarks of the literature, and evidence quality rating/strength of recommendation of laser procedures. RESULTS: Of 729 potentially eligible articles, 28 papers (26 studies) were included in the review. Individual study outcomes and four sets of meta-analysis showed potential statistical significant benefit of aPDT in improving clinical attachment level (CAL) (non-surgical treatment of AgP) and probing depth (PD) (non-surgical treatment of AgP and CP). However, the comparative differences in clinical outcomes were modest (< 1 mm), and the level of certainty for different therapies was considered low-to-moderate (i.e., more information would be necessary to allow for a reliable and definitive estimation of effect/magnitude of therapies on health outcomes). Overall, most of the strengths of clinical recommendations of aPDT were guided by the expert opinion. CONCLUSIONS: aPDT may provide similar clinical improvements in PD and CAL when compared with conventional periodontal therapy for both periodontitis and peri-implantitis patients. The restricted base of evidence for some treatment approaches and conditions precludes additional conclusions. Copyright © 2018 American Academy of Periodontology. Publication Type Journal Article. Year of Publication 2018 <56> Unique Identifier 30133748 Title Laser therapy for treatment of peri-implant mucositis and peri-implantitis: An American Academy of Periodontology best evidence review. Source Journal of Periodontology. 89(7):766-782, 2018 Jul. VI 1 Status In-Data-Review Authors Lin GH; Suarez Lopez Del Amo F; Wang HL. Authors Full Name Lin, Guo-Hao; Suarez Lopez Del Amo, Fernando; Wang, Hom-Lay. Institution Lin, Guo-Hao. Department of Periodontics and Oral Medicine, University of Michigan School of Dentistry, Ann Arbor, MI. Lin, Guo-Hao. Department of Orofacial Sciences, University of California San Francisco School of Dentistry, San Francisco, CA. Suarez Lopez Del Amo, Fernando. Department of Periodontics and Oral Medicine, University of Michigan School of Dentistry, Ann Arbor, MI. Suarez Lopez Del Amo, Fernando. Department of Periodontics, University of Oklahoma College of Dentistry, Norman, OK. Wang, Hom-Lay. Department of Periodontics and Oral Medicine, University of Michigan School of Dentistry, Ann Arbor, MI. Local Messages THIS JOURNAL IS AVAILABLE IN THE BDA LIBRARY, TO REQUEST THIS ARTICLE FROM THE LIBRARY GO TO: https://www.bda.org/library/journals-articles/Documents/photocopy-request-form.pdf Abstract BACKGROUND: Peri-implant diseases are prevalent, with numerous therapies studied in an attempt to combat this condition. The present review aims to systematically evaluate the effectiveness of laser therapy with non-surgical or surgical therapy in managing peri-implant mucositis and peri-implantitis. METHODS: An electronic search of three databases and a hand search of peer-reviewed journals for relevant articles published (in English) from January 1980 to June 2016 were performed. Human clinical trials of >= 10 patients with peri-implant diseases, treated with surgical or non-surgical approaches and laser therapy, and a follow-up period of >= 6 months, were included. Random-effects meta-analyses were performed to analyze weighted mean difference (WMD) and confidence interval for the recorded variables according to PRISMA guidelines. Risk of bias assessment was also performed for randomized controlled trials included. RESULTS: From 22 articles selected, 11 were included in the meta-analyses. The outcomes of using lasers as a monotherapy could not be evaluated since no controlled studies were identified. Therefore, all reported results were the outcomes of applying lasers as an adjunct to surgical/non-surgical treatment. For the non-surgical approach, WMD of probing depth (PD), clinical attachment level (CAL), bleeding on probing (BOP), plaque index (PI), marginal bone level (MBL) and recession (REC) was 0.15 mm (P = 0.50), -0.10 mm (P = 0.32), 21.08% (P = 0.02), -0.07 (P = 0.002), -0.22 mm (P = 0.04) and -0.11 mm (P = 0.34), respectively. For the surgical approach with a long-term follow up, WMD of PD, CAL, BOP, and PI was 0.45 mm (P = 0.11), 0.22 mm (P = 0.56), 7.26% (P = 0.76) and -0.09 (P = 0.84), respectively. CONCLUSIONS: Current evidence shows laser therapy in combination with surgical/non-surgical therapy provided minimal benefit in PD reduction, CAL gain, amount of REC improvement, and PI reduction in the treatment of peri-implant diseases. Lasers when used as an adjunct to non-surgical therapy might result in more BOP reduction in the short term. However, current evidence allowed for analysis of only Er:YAG, CO2 , and diode lasers. Studies on others failed to have controlled evidence supporting their evaluation.

Copyright © 2018 American Academy of Periodontology. Publication Type Journal Article. Year of Publication 2018 <57> Unique Identifier 29682757 Title Infrared lasers for the treatment of moderate to severe periodontitis: An American Academy of Periodontology best evidence review. Source Journal of Periodontology. 89(7):743-765, 2018 Jul. VI 1 Status In-Data-Review Authors Chambrone L; Ramos UD; Reynolds MA. Authors Full Name Chambrone, Leandro; Ramos, Umberto D; Reynolds, Mark A. Institution Chambrone, Leandro. School of Dentistry, Ibirapuera University (Unib), Sao Paulo, Brazil. Chambrone, Leandro. Unit of Basic Oral Investigation (UIBO), School of Dentistry, El Bosque University, Bogota, Colombia. Ramos, Umberto D. Private Practice, Vitoria, ES, Brazil. Reynolds, Mark A. Department of Advanced Oral Sciences and Therapeutics, School of Dentistry, University of Maryland, Baltimore, MD. Local Messages THIS JOURNAL IS AVAILABLE IN THE BDA LIBRARY, TO REQUEST THIS ARTICLE FROM THE LIBRARY GO TO: https://www.bda.org/library/journals-articles/Documents/photocopy-request-form.pdf Abstract BACKGROUND: This systematic review assesses the efficacy of infrared laser therapy used alone or as an adjunct to nonsurgical or surgical periodontal therapy, on clinical and patient-centered outcomes in patients with periodontitis. METHODS: Randomized clinical trials (RCTs) with a follow-up duration >=3 months that evaluated root surface debridement (i.e., scaling and root debridement with or without surgical access) to laser therapy alone or laser therapy plus root surface debridement for the treatment of adult patients (>=18 years old) with moderate to severe aggressive or chronic periodontitis were considered eligible for inclusion. The MEDLINE, EMBASE and CENTRAL databases were searched for articles published up to and including March 2016. Random effects meta-analyses were used throughout the review using continuous data (i.e., mean changes from baseline), and pooled estimates were expressed as weighted mean differences (MDs) with their associated 95% confidence intervals (CIs). Additionally, summaries are presented of the included RCTs, critical remarks of the literature and evidence quality rating/strength of recommendation of laser procedures. RESULTS: Of the 475 potentially eligible articles, 28 were included in the review. Individual study outcomes and seven sets of meta-analysis (1 for the nonsurgical treatment of AgP and 9 for nonsurgical and surgical treatment of CP) showed a benefit of laser therapy in improving clinical attachment level (CAL) and probing depth (PD). However, the comparative differences in clinical outcomes were modest (< 1 mm) and the level of certainty for different therapies was considered low-to-moderate (i.e., more information would be necessary to allow for a reliable and definitive estimation of effect/magnitude of therapies on health outcomes). Overall, most of the Strength of Clinical Recommendations of laser therapies were considered weak or based on expert opinion. CONCLUSIONS: In patients with moderate to severe periodontitis, the nonsurgical treatment of AgP and CP by SRP plus infrared diode laser, and the surgical treatment of CP by Er:YAG laser therapy alone may promote statistically significant improvements in PD and CAL. However, these gains are relatively small (< 1 mm) and provide modest clinical relevance compared with SRP alone. Copyright © 2018 American Academy of Periodontology. Publication Type Journal Article. Year of Publication 2018 <58> Unique Identifier 29492963 Title Efficacy of systemic antibiotics in nonsurgical periodontal therapy for diabetic subjects: a systematic review and meta-analysis. [Review] Source International Dental Journal. 68(4):207-220, 2018 Aug. VI 1 Status In-Process Authors Souto MLS; Rovai ES; Ganhito JA; Holzhausen M; Chambrone L; Pannuti CM.

Authors Full Name Souto, Maria Luisa S; Rovai, Emanuel S; Ganhito, Juliana A; Holzhausen, Marinella; Chambrone, Leandro; Pannuti, Claudio M. Institution Souto, Maria Luisa S. Division of Periodontics, School of Dentistry, University of Sao Paulo, Sao Paulo, Brazil. Rovai, Emanuel S. Division of Periodontics, School of Dentistry, University of Sao Paulo, Sao Paulo, Brazil. Ganhito, Juliana A. Division of Periodontics, School of Dentistry, University of Sao Paulo, Sao Paulo, Brazil. Holzhausen, Marinella. Division of Periodontics, School of Dentistry, University of Sao Paulo, Sao Paulo, Brazil. Chambrone, Leandro. Unit of Basic Oral Investigations, El Bosque University, Bogota, Colombia. Pannuti, Claudio M. Division of Periodontics, School of Dentistry, University of Sao Paulo, Sao Paulo, Brazil. Local Messages THIS JOURNAL IS AVAILABLE IN THE BDA LIBRARY, TO REQUEST THIS ARTICLE FROM THE LIBRARY GO TO: https://www.bda.org/library/journals-articles/Documents/photocopy-request-form.pdf Abstract OBJECTIVES: To evaluate the effects of systemic antibiotics as adjuncts to nonsurgical periodontal treatment (NSPT), as opposed to using NSPT alone, on periodontal clinical parameters of diabetic patients with periodontitis. MATERIALS AND METHODS: Randomised controlled trials with a follow-up of 3 months or more, assessing the effects of NSPT in combination with antibiotics, in diabetic patients with periodontitis were included. Trials published up to August 2016 were identified from MEDLINE, EMBASE and LILACS databases. Meta-analyses were conducted to determine changes in clinical attachment level (CAL), probing pocket depth (PPD), bleeding on probing (BOP) and gingival index (GI). Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines were followed in this review. RESULTS: Of the 164 papers potentially admissible to this systematic review, 15 articles on 11 randomised clinical trials were considered as eligible. The results of the meta-analyses presented a modest additional benefit of 0.14 mm (95% confidence interval: 0.08-0.20) in reducing PPD but no further benefit in CAL gain. CONCLUSION: When the data for all antibiotic protocols were considered together for the treatment of periodontitis patients with DM, a significant, albeit small, reduction of PPD and no improvement in CAL gain was observed. When the antibiotic protocols were analysed separately, the combination of amoxicillin plus metronidazole yielded the best results for PPD. Copyright © 2018 FDI World Dental Federation. Publication Type Journal Article. Review. Year of Publication 2018 <59> Unique Identifier 30116515 Title Use of Autologous Stem Cells for the Regeneration of Periodontal Defects in Animal Studies: a Systematic Review and Meta-Analysis. [Review] Source Journal of Oral & Maxillofacial Research. 9(2):e3, 2018 Apr-Jun. VI 1 Status PubMed-not-MEDLINE Authors Gaubys A; Papeckys V; Pranskunas M. Authors Full Name Gaubys, Algimantas; Papeckys, Valdas; Pranskunas, Mindaugas. Institution Gaubys, Algimantas. Department of Maxillofacial Surgery, Lithuanian University of Health Sciences, KaunasLithuania. Papeckys, Valdas. Department of Maxillofacial Surgery, Lithuanian University of Health Sciences, KaunasLithuania. Pranskunas, Mindaugas. Department of Maxillofacial Surgery, Lithuanian University of Health Sciences, KaunasLithuania. Abstract Objectives: To overview preclinical animal trials and quantify the effect size that stem cell therapy has on the regeneration of periodontal tissue complex. Material and Methods: A systematic MEDLINE (PubMed) online library search was conducted for preclinical animal studies in vivo , using autologous periodontal ligament, dental pulp, cementum, alveolar periosteal, gingival margin or adipose stem cell types for periodontal tissue complex regeneration purposes. Studies had to be published between 2007.09.01 and 2017.09.01 in the English language. Results: Online library search yielded 2099 results. After the title, abstract and full-text screening ten studies fit inclusion criteria and were pooled into meta-analysis. Overall the stem cell regenerative therapy had a statistically significant positive influence on the periodontal tissue regeneration when compared to the control groups. The biggest influence was made to the regeneration of cementum (standardised mean difference [SMD] 2.25 [95% confidence interval (CI) = 1.31 to 3.2]) while the smallest influence was made to the alveolar bone (SMD 1.47 [95% CI = 0.7 to 2.25]) the effect size for periodontal ligament regeneration was (SMD 1.8 [95% CI = 1 to 2.59]). Subgroup analysis showed statistically significant (P < 0.05) differences between different cell types in the alveolar bone and cementum regeneration groups and in alveolar bone group in relation to scaffold materials. Conclusions: Stem cell therapy has a positive impact on periodontal tissue complex regeneration. Such therapy has the biggest influence on cementum regeneration meanwhile alveolar bone regeneration is influenced by the least amount. However more and less diverse preclinical studies are needed to have a greater statistical power in future meta-analyses.

Publication Type Journal Article. Review. Year of Publication 2018 <60> Unique Identifier 29948277 Title Locally applied statins as adjuvants to non-surgical periodontal treatment for chronic periodontitis: a systematic review and meta-analysis. [Review] Source Clinical Oral Investigations. 22(7):2413-2430, 2018 Sep. VI 1 Status In-Process Authors Meza-Mauricio J; Soto-Penaloza D; Penarrocha-Oltra D; Montiel-Company JM; Peruzzo DC. Authors Full Name Meza-Mauricio, Jonathan; Soto-Penaloza, David; Penarrocha-Oltra, David; Montiel-Company, Jose Maria; Peruzzo, Daiane Cristina. Institution Meza-Mauricio, Jonathan. Department of Periodontology, Guarulhos University, Rua Nilo Pecanha, 68, Guarulhos, SP, Brazil. [email protected]. Soto-Penaloza, David. Stomatology Department School of Medicine and Dentistry, University of Valencia, Valencia, Spain. Penarrocha-Oltra, David. Stomatology Department School of Medicine and Dentistry, University of Valencia, Valencia, Spain. Montiel-Company, Jose Maria. Stomatology Department School of Medicine and Dentistry, University of Valencia, Valencia, Spain. Peruzzo, Daiane Cristina. Sao Leopoldo Mandic Dental Institute and Research Centre, Campinas, SP, Brazil. Local Messages THIS JOURNAL IS AVAILABLE IN THE BDA LIBRARY, TO REQUEST THIS ARTICLE FROM THE LIBRARY GO TO: https://www.bda.org/library/journals-articles/Documents/photocopy-request-form.pdf Abstract OBJECTIVE: This review aimed at evaluating the effects of chronic periodontitis (CP) treatment with local statins as adjuncts to scaling and root planing (SRP), compared with SRP alone or with placebo. METHODS: Electronic and hand searches were conducted in three databases to select randomized controlled trials (RCTs) comparing SRP + statins versus SRP alone. Random effects models were conducted to determine the clinical attachment level (CAL) gain as the primary outcome variable, and probing pocket depth (PPD) reduction, modified sulcus bleeding index (mSBI), and intrabony defect depth (IBD) as the secondary outcomes. RESULTS: Of the 526 papers identified, 15 articles met the criteria for inclusion in this systematic review, and 13 in the meta-analysis. The meta-analysis showed a statistically significant CAL gain (mean differences [MD] = 1.84 mm, 95% confidence interval [CI] = 1.45 to 2.23; p = 0.000), PPD reduction (MD = 1.69 mm, 95% CI = 1.37 to 2.04; p = 0.000), mSBI change (MD = 0.70, 95% CI = 0.57 to 0.84; p = 0.000), and IBD (MD = 1.48, 95% CI = 1.30 to 1.67; p = 0.000) attributed to SRP + statin treatment (6 months). CONCLUSION: Within the limitations of this study, the collective evidence emerging from this systematic review and meta-analysis may support the use of locally applied statins as adjuncts to SRP in CP treatment, based on being an easy, low-cost alternative, with lesser adverse effects on bacterial resistance. These results should be interpreted with caution. CLINICAL RELEVANCE: Clinicians might consider the use of SRP + statins as an adjunct over other alternative approaches, based on the results of the present review. The informed decision should be taken, considering the patient's values and preferences, and the intervention to be implemented by the clinician. Publication Type Journal Article. Review. Year of Publication 2018 <61> Unique Identifier 29203147 Title Interrelation of periodontal parameters between asthmatics and nonasthmatics subjects: a systematic review and meta-analysis. [Review][Erratum appears in J Dent. 2018 Aug 4;:; PMID: 30086996] Source Journal of Dentistry. 69:32-40, 2018 Feb. VI 1 Status In-Data-Review Authors Mendes V; Oliveir G; Santos D; Moraschini V. Authors Full Name Mendes, Vivian; Oliveir, Gustavo; Santos, Dos; Moraschini, Vittorio. Institution

Mendes, Vivian. Department of Integrated Clinics, School of Dentistry, Fluminense Federal University, Niteroi, Rio de Janeiro, Brazil. Oliveir, Gustavo. Department of Integrated Clinics, School of Dentistry, Fluminense Federal University, Niteroi, Rio de Janeiro, Brazil. Santos, Dos. Department of Integrated Clinics, School of Dentistry, Fluminense Federal University, Niteroi, Rio de Janeiro, Brazil. Moraschini, Vittorio. Department of Periodontology, School of Dentistry, Fluminense Federal University, Niteroi, Rio de Janeiro, Brazil. Local Messages THIS JOURNAL IS AVAILABLE IN THE BDA LIBRARY, BDA MEMBERS CAN ALSO ACCESS THIS JOURNAL ONLINE FROM 2011 TO DATE. Go to www.bda.org/ejournals Abstract BACKGROUND: The aim of this systematic review (SR) is to evaluate the association between asthma and periodontal parameters. METHODS: An electronic search without date or language restrictions was carried out in MEDLINE, Cochrane, Web of Science, and LILACS until May 2017. In addition, manual search and in the grey literature were also conducted. The search process, data analysis, and quality assessment were performed by two independent reviewing authors. Eligibility criteria included prospective and retrospective cohort studies, case-controls, and randomized clinical trials. For the meta-analysis, the inverse variance method was used in fixed or random effect models, which were chosen according to heterogeneity. The estimates of the intervention effects were expressed as the mean differences. RESULTS: The search and selection process yielded 21 studies, published between 1979 and 2017. The meta-analysis showed a statistically significant difference for the parameters of gingival bleeding, plaque index, and gingival index for asthmatic participants with P<0.0001, P<0.0001, and P=0.0005, respectively. CONCLUSIONS: The data from this SR suggest that asthmatic patients may be more susceptible to negative periodontal changes, althought further high-quality research wuold be welcome. Copyright © 2017 Elsevier Ltd. All rights reserved. Publication Type Journal Article. Review. Year of Publication 2018 <62> Unique Identifier 30083109 Title Periodontal Disease and Risk of Bladder Cancer: A Meta-Analysis of 298476 Participants. Source Frontiers in Physiology. 9:979, 2018. VI 1 Status PubMed-not-MEDLINE Authors Xie WZ; Jin YH; Leng WD; Wang XH; Zeng XT; BPSC investigators. Authors Full Name Xie, Wen-Zhong; Jin, Ying-Hui; Leng, Wei-Dong; Wang, Xing-Huan; Zeng, Xian-Tao; BPSC investigators. Institution Xie, Wen-Zhong. Department of Stomatology, Kaifeng Stomatological Hospital, Kaifeng Central Hospital, Kaifeng, China. Jin, Ying-Hui. Center for Evidence-Based and Translational Medicine, Zhongnan Hospital of Wuhan University, Wuhan, China. Leng, Wei-Dong. Department of Stomatology, Taihe Hospital, Hubei University of Medicine, Shiyan, China. Wang, Xing-Huan. Center for Evidence-Based and Translational Medicine, Zhongnan Hospital of Wuhan University, Wuhan, China. Wang, Xing-Huan. Department of Urology, Zhongnan Hospital of Wuhan University, Wuhan, China. Zeng, Xian-Tao. Department of Stomatology, Kaifeng Stomatological Hospital, Kaifeng Central Hospital, Kaifeng, China. Zeng, Xian-Tao. Center for Evidence-Based and Translational Medicine, Zhongnan Hospital of Wuhan University, Wuhan, China. Zeng, Xian-Tao. Department of Stomatology, Taihe Hospital, Hubei University of Medicine, Shiyan, China. Zeng, Xian-Tao. Department of Urology, Zhongnan Hospital of Wuhan University, Wuhan, China. Abstract Objective: It has been reported that the periodontal disease is linked to a number of malignant tumors such as lung cancer and pancreatic cancer. In this study, we aimed to investigate the association of periodontal disease with risk of bladder cancer by a meta-analysis. Methods: PubMed, Scopus, ScienceDirect, and Chinese National Knowledge Infrastructure (CNKI) were searched for eligible publications up to December 15, 2017. Cohort and nested case-control studies on the association between periodontal disease and risk of bladder cancer were included. After study selection and data extraction, pooled hazard ratios (HRs) and their 95% confidence intervals (95%CIs) were calculated using a fixed-effect inverse-variance model. All analyses were performed using the RevMan 5.3 software. Results: Finally, five cohort studies were identified and included in this meta-analysis, involving 1,104 bladder cancer cases of 298,476 participants. Summary estimates based on adjusted data showed that periodontal disease was not significantly associated with the risk of bladder cancer (HR = 1.09, 95% CI = 0.95-1.25, I2 = 0%). A similar result was also observed after cumulative, subgroup and sensitivity analyses. Conclusions: Current evidence from cohort studies suggests that patients with periodontal disease may not be at an increased risk of developing bladder cancer. Publication Type

Journal Article. Year of Publication 2018 <63> Unique Identifier 30077379 Title The Use of Amoxicillin (500 Mg) Plus Metronidazole (500 Mg) for 7 Days Adds Adjunctive Benefits for Nonsurgical Periodontal Therapy, but Limited Evidence Supports Higher/Longer Dose. Source The Journal of Evidencebased Dental Practice. 18(3):249-251, 2018 Sep. VI 1 Status In-Data-Review Authors Wang JC. Authors Full Name Wang, Jeff Chin-Wei. Abstract ARTICLE TITLE AND BIBLIOGRAPHIC INFORMATION: Optimal dose and duration of amoxicillin-plus-metronidazole as an adjunct to nonsurgical periodontal therapy: A systematic review and meta-analysis of randomized, placebo-controlled trials. McGowan K, McGowan T, Ivanovski S. J Clin Periodontol 2018;45:56-67. SOURCE OF FUNDING: Information not available. TYPE OF STUDY/DESIGN: Systematic review with meta-analysis of data. Copyright © 2018 Elsevier Inc. All rights reserved. Publication Type Journal Article. Year of Publication 2018 <64> Unique Identifier 30077375 Title An Umbrella Review Exploring the Effect of Periodontal Treatment in Pregnant Women on the Frequency of Adverse Obstetric Outcomes. Source The Journal of Evidencebased Dental Practice. 18(3):218-239, 2018 Sep. VI 1 Status In-Data-Review Authors Rangel-Rincon LJ; Vivares-Builes AM; Botero JE; Agudelo-Suarez AA. Authors Full Name Rangel-Rincon, Leidy Johana; Vivares-Builes, Annie M; Botero, Javier Enrique; Agudelo-Suarez, Andres A. Institution Rangel-Rincon, Leidy Johana. Center of Research, Faculty of Dentistry, University of Antioquia, Medellin, Colombia. Vivares-Builes, Annie M. Center of Research, Faculty of Dentistry, University of Antioquia, Medellin, Colombia. Botero, Javier Enrique. Center of Research, Faculty of Dentistry, University of Antioquia, Medellin, Colombia. Agudelo-Suarez, Andres A. Center of Research, Faculty of Dentistry, University of Antioquia, Medellin, Colombia. Electronic address: [email protected]. Abstract OBJECTIVE: In the recent years, efforts have been made to reduce epidemiologic indicators of periodontal disease in pregnant women. This umbrella review aims to analyze the systematic reviews/meta-analyses investigating the effect of periodontal therapy in pregnant women on the frequency of obstetric complications (low birth weight, preterm delivery, and preeclampsia) and to identify the gaps in the scientific literature. METHODS: A systematic review of systematic reviews with and without meta-analysis of intervention studies was conducted. Quality evaluation and qualitative analysis of the reviews were performed. RESULTS: A total of 223 articles were obtained, and 18 of them were included in the analysis, 13 articles included meta-analysis, where 11 were of high quality and 7 of medium quality according to the Assessing the Methodological Quality of Systematic Reviews (AMSTAR) guide. These systematic reviews/meta-analyses included a total of 19 studies (17 randomized clinical trials). Descriptive systematic reviews showed that periodontal therapy has positive effects on reducing the frequency of adverse pregnancy outcomes. In systematic reviews with meta-analysis, overall effect estimators were not significant, although a reduction in the incidence of obstetric complications was observed. Subgroup analysis resulted in significant effects, depending on sociodemographic conditions. CONCLUSIONS: Differential findings are not enough to demonstrate that there is a significant reduction in the frequency of adverse pregnancy outcomes in pregnant women receiving periodontal therapy. Possible explanations are related to factors such

as the type of studies analyzed, indicator of obstetric complication considered, and specific variables included in the analysis. Many systematic reviews did not address publication bias and did identify gaps in knowledge that require further clarification. Copyright © 2017 Elsevier Inc. All rights reserved. Publication Type Journal Article. Year of Publication 2018 <65> Unique Identifier 30077376 Title Intrapocket and/or Topical Anesthetic Options Offer an Alternative to Injected Anesthesia During Scaling and Root Planing in Patients With Shallow to Moderate Periodontal Pockets. Source The Journal of Evidencebased Dental Practice. 18(3):240-242, 2018 Sep. VI 1 Status In-Data-Review Authors Derman SHM. Authors Full Name Derman, Sonja H M. Abstract ARTICLE TITLE AND BIBLIOGRAPHIC INFORMATION: Intrapocket topical anesthetic versus injected anesthetic for pain control during scaling and root planing in adult patients: systematic review and meta-analysis. Wambier LM, de Geus JL, Boing TF, Chibinski ACR, Wambier DS, Rego RO, Loguercio AD, Reis A. J Am Dent Assoc 2017;148(11):814-24.e812. SOURCE OF FUNDING: Institutional, State University of Ponta Grossa, Ponta Grossa, Parana, Brazil. TYPE OF STUDY/DESIGN: Systematic review with meta-analysis of data. Copyright © 2018 Elsevier Inc. All rights reserved. Publication Type Journal Article. Year of Publication 2018 <66> Unique Identifier 29921415 Title Periodontal health during orthodontic treatment with clear aligners and fixed appliances: A meta-analysis. [Review] Source Journal of the American Dental Association. 149(8):712-720.e12, 2018 Aug. VI 1 Status In-Data-Review Authors Jiang Q; Li J; Mei L; Du J; Levrini L; Abbate GM; Li H. Authors Full Name Jiang, Qian; Li, Jialing; Mei, Li; Du, Jing; Levrini, Luca; Abbate, Gian Marco; Li, Huang. Local Messages THIS JOURNAL IS AVAILABLE IN THE BDA LIBRARY, BDA MEMBERS CAN ALSO ACCESS THIS JOURNAL ONLINE FROM 1995 TO DATE. Go to www.bda.org/ejournals Abstract BACKGROUND: Clear aligners have become increasingly popular because of their esthetics and comfort. The authors' aim in this systematic review was to compare periodontal health in patients undergoing orthodontic treatment with clear aligners with that of those undergoing orthodontic treatment with fixed appliances. TYPES OF STUDIES REVIEWED: The authors systematically searched the PubMed, Web of Science, Cochrane Library, and Embase databases to collect related studies. After extracting data and assessing quality, the authors performed a meta-analysis and trial sequential analysis. The authors used the Grading of Recommendations Assessment, Development and Evaluation system to assess the quality of the evidence. RESULTS: The authors included 9 studies in the quantitative synthesis analysis. Clear aligners were better for periodontal health, including plaque index (mean difference [MD], -0.53; 95% confidence interval [CI], -0.85 to -0.20; P = .001), gingival index (MD, -0.27; 95% CI, -0.37 to -0.17; P < .001), and probing depth (MD, -0.35; 95% CI, -0.67 to -0.03; P = .03), than were fixed appliances. However, the trial sequential analysis outcome indicated a false-positive meta-analysis result for probing depth. The authors downgraded the level of the evidence because of the risk of bias and inconsistency. CONCLUSIONS AND PRACTICAL IMPLICATIONS: Clear aligners were better for periodontal health than fixed appliances and might be recommended for patients at high risk of developing gingivitis. However, high-quality studies still are required.

Copyright © 2018 American Dental Association. Published by Elsevier Inc. All rights reserved. Publication Type Journal Article. Review. Year of Publication 2018 <67> Unique Identifier 30005079 Title Efficacy of Hank's balanced salt solution compared to other solutions in the preservation of the periodontal ligament. A systematic review and meta-analysis. Source PLoS ONE [Electronic Resource]. 13(7):e0200467, 2018. VI 1 Status In-Data-Review Authors Fagundes NCF; Bittencourt LO; Magno MB; Marques MM; Maia LC; Lima RR. Author NameID Lima, Rafael Rodrigues; ORCID: http://orcid.org/0000-0003-1486-4013 Authors Full Name Fagundes, Nathalia Carolina Fernandes; Bittencourt, Leonardo Oliveira; Magno, Marcela Barauna; Marques, Marcia Martins; Maia, Lucianne Cople; Lima, Rafael Rodrigues. Institution Fagundes, Nathalia Carolina Fernandes. Laboratory of Functional and Structural Biology, Institute of Biological Sciences, Universidade Federal do Para, Belem-Para, Brazil. Fagundes, Nathalia Carolina Fernandes. School of Dentistry, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Canada. Bittencourt, Leonardo Oliveira. Laboratory of Functional and Structural Biology, Institute of Biological Sciences, Universidade Federal do Para, Belem-Para, Brazil. Magno, Marcela Barauna. Department of Pediatric Dentistry and Orthodontics, School of Dentistry, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil. Marques, Marcia Martins. Department of Restorative Dentistry, School of Dentistry, Universidade de Sao Paulo, Sao Paulo, Brazil. Maia, Lucianne Cople. School of Dentistry, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Canada. Lima, Rafael Rodrigues. Laboratory of Functional and Structural Biology, Institute of Biological Sciences, Universidade Federal do Para, Belem-Para, Brazil. Abstract This systematic review and meta-analysis (MA) aimed to verify the capacity of different storage media to preserve viability of periodontal ligament cells in comparison to Hank's Balanced Salt Solution. The searches, selection process, data extraction and Risk of Bias control were conducted according to Preferred Reporting Items for Systematic Review and Meta-Analysis guidelines. Five MA were conducted to compare the cell viability between milk versus Hank's balanced salt solution (HBSS) in a dichotomous (1) or continuous (2) data model; tap water versus HBSS (3); medicinal herbals versus HBSS (4); and saline solution versus HBSS (5). 693 potentially studies were identified, with 18 studies included in the qualitative and 8 studies included in the quantitative analysis. Most of the articles presented a low risk of bias. HBSS medium showed a superior ratio of cell viability compared to tap water (RR 0.26; 95% CI [0.21, 0.32]; p < 0.00001; I2 = 96%) and saline solution (RR 0.76; 95% CI [0.69, 0.84]; p < 0.0001; I2 = 99%). Herbal medicines showed a similar ratio of cell viability when compared to HBSS (RR 0.97; 95% CI [0.94, 1.00]; p = 0.08; I2 = 50%). Mixed results were observed between milk and HBSS: a superior ratio of HBSS was observed in an overall evaluation (RR 0.26; 95% CI [0.21, 0.32]; p < 0.00001; I2 = 96%), and a similar ratio was achieved when periodontal ligament (PDL) cells were removed prior to immersion in the solution (RR 0.94; 95% CI [0.87, 1.01]; p = 0.10; I2 = 0%) or rinsed in tap water or maintained in open air prior to immersion (RR 0.63; 95% CI [0.35, 1.12]; p = 0.11; I2 = not applicable). This systematic review and MA suggests that milk and herbal medicines could represent an alternative to HBSS. However, more studies are necessary to obtain a reliable conclusion. Publication Type Journal Article. Year of Publication 2018 <68> Unique Identifier 29325853 Title Relationship between sjogren syndrome and periodontal status: A systematic review. [Review] Source Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology. 125(3):223-231, 2018 03. VI 1 Status In-Process Authors de Goes Soares L; Rocha RL; Bagordakis E; Galvao EL; Douglas-de-Oliveira DW; Falci SGM. Authors Full Name de Goes Soares, Luana; Rocha, Ricardo Lopes; Bagordakis, Elizabete; Galvao, Endi Lanza; Douglas-de-Oliveira, Dhelfeson Willya; Falci, Saulo Gabriel Moreira. Institution

de Goes Soares, Luana. Department of Dentistry, Federal University of Jequitinhonha and Mucuri Valleys, Diamantina, MG, Brazil. Rocha, Ricardo Lopes. Department of Dentistry, Federal University of Jequitinhonha and Mucuri Valleys, Diamantina, MG, Brazil. Bagordakis, Elizabete. Department of Dentistry, Federal University of Jequitinhonha and Mucuri Valleys, Diamantina, MG, Brazil. Galvao, Endi Lanza. Rene Rachou Research Center, Oswaldo Cruz Fundation, Belo Horizonte, Brazil. Douglas-de-Oliveira, Dhelfeson Willya. Department of Dentistry, Federal University of Jequitinhonha and Mucuri Valleys, Diamantina, MG, Brazil; Department of Periodontology, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil. Falci, Saulo Gabriel Moreira. Department of Dentistry, Federal University of Jequitinhonha and Mucuri Valleys, Diamantina, MG, Brazil. Electronic address: [email protected]. Local Messages THIS JOURNAL IS AVAILABLE IN THE BDA LIBRARY, BDA MEMBERS CAN ALSO ACCESS THIS JOURNAL ONLINE FROM 2011 TO DATE. Go to www.bda.org/ejournals Abstract OBJECTIVE: This study aimed to examine whether Sjogren syndrome (SS) is related to periodontal status. STUDY DESIGN: A systematic review was performed on the basis of PRISMA (PROSPERO: CRD42017055202). A search was performed in the PubMed/MEDLINE, LILACS, Web of Science, and Science Direct databases. Hand searches and review of the gray literature were also performed. Three researchers independently selected studies, extracted data, and assessed methodologic quality. Studies that correlated primary and/or secondary SS with plaque index, gingival index, probing depth, and bleeding on probing were included. The risk of bias was estimated on the basis of the Newcastle-Ottawa scale. RESULTS: Seventeen studies were included in the review and 9 included in the meta-analysis, with a total of 518 and 544 patients, with or without SS, respectively. The mean difference of plaque index (0.29; 95% confidence interval [CI] 0.17-0.41), gingival index (0.52; 95% CI 0.14-0.89), and bleeding on probing (9.92; 95% CI 4.37-15.47) were larger in patients with SS than in controls. In primary SS (0.47; 95% CI 0.10-0.83) and secondary SS (0.74; 95% CI 0.10-1.38), only the mean gingival index was larger compared with that in control group. The majority of the included studies were judged as having a high risk of bias. CONCLUSIONS: The present review did not provide strong evidence that periodontal status is affected by SS. Copyright © 2017 Elsevier Inc. All rights reserved. Publication Type Journal Article. Review. Year of Publication 2018 <69> Unique Identifier 30036945 Title Dietary Polyphenols and Periodontitis-A Mini-Review of Literature. [Review] Source Molecules. 23(7), 2018 Jul 20. VI 1 Status In-Process Authors Basu A; Masek E; Ebersole JL. Author NameID Ebersole, Jeffrey L; ORCID: https://orcid.org/0000-0002-9743-6585 Authors Full Name Basu, Arpita; Masek, Emily; Ebersole, Jeffrey L. Institution Basu, Arpita. Department of Kinesiology and Nutrition Sciences, School of Allied Health Sciences, University of Nevada Las Vegas, 4505 S Maryland Parkway, Las Vegas, NV 89154, USA. [email protected]. Masek, Emily. Department of Kinesiology and Nutrition Sciences, School of Allied Health Sciences, University of Nevada Las Vegas, 4505 S Maryland Parkway, Las Vegas, NV 89154, USA. [email protected]. Ebersole, Jeffrey L. Department of Biomedical Sciences, School of Dental Medicine, University of Nevada Las Vegas, Las Vegas, NV 89154, USA. [email protected]. Abstract Periodontitis, which is a chronic infection and disease of the periodontium, is a significant global health burden and is linked to other chronic health conditions such as diabetes and cardiovascular diseases. Dietary polyphenols present in a wide variety of plant-based foods, herbs, and botanicals have been shown to exert antimicrobial, anti-inflammatory, and reduced osteoclast and alveolar bone loss activities in animal models of periodontitis. Polyphenol-containing beverages and foods especially green tea and its active catechin epigallocatechin-3-gallate, cranberries, pomegranates, and fruit and vegetable extracts have reported bacteriostatic/bactericidal activity against microbial species such as P. gingivalis and shown total bacterial burden in clinical studies. These polyphenols also exhibit anti-inflammatory and antioxidant effects, which have the potential to impact various biological mechanisms for reducing the initiation and progression of periodontitis. The main objective of this mini-review is to focus on the mechanisms of action of dietary polyphenols in improving the pathophysiology underlying chronic inflammatory diseases like periodontitis based on pre-clinical and clinical models. Publication Type Journal Article. Review. Year of Publication 2018

<70> Unique Identifier 30026890 Title LANAP, Periodontics and Beyond: A Review. Source Journal of Lasers in Medical Sciences. 9(2):76-81, 2018. VI 1 Status PubMed-not-MEDLINE Authors Jha A; Gupta V; Adinarayan R. Authors Full Name Jha, Amrita; Gupta, Vivek; Adinarayan, Roopa. Institution Jha, Amrita. Department of Periodontology and Oral Implantology, Rama Dental College, Hospital and Research Centre Kanpur, U.P. India. Gupta, Vivek. Department of Periodontology and Oral Implantology, Dental Institute RIMS Ranchi, Jharkhand, India. Adinarayan, Roopa. Department of Periodontology and Oral Implantology, Rama Dental College, Hospital and Research Centre Kanpur, U.P. India. Abstract Laser has emerged as an adjunct in several treatment modalities in dentistry in the past few decades. This less invasive bladeless technique is bringing revolutionary outcomes in a plethora of periodontal treatment procedures as well. A unique ameliorative approach termed LANAP, described as laser-assisted new attachment procedure was developed by Gregg and McCarthy. In 1990 they introduced an innovative treatment for diseases of gums incorporating pulsed neodymium yttrium aluminum garnet (Nd: YAG) 1064 nm wavelength laser (PerioLase MVP7). The LANAP concept was endorsed by Yukna et al who conducted a study according to the protocol reinforced at the1996 world workshop in periodontics, which established specific histologic criteria to prove regeneration. Yukna's histological study found that regeneration of the periodontally compromised root could be achieved by Nd: YAG laser. LANAP facilitates refurbishing of new tissues from supporting structures of the periodontium wherein the unhealthy surface of the roots exhibit pristine attachments in human beings. This paper is a review providing a detailed report of LANAP from its inception to recent advances. Publication Type Journal Article. Year of Publication 2018 <71> Unique Identifier 29984691 Title Improving the Quality of Dentistry (IQuaD): a cluster factorial randomised controlled trial comparing the effectiveness and cost-benefit of oral hygiene advice and/or periodontal instrumentation with routine care for the prevention and management of periodontal disease in dentate adults attending dental primary care. Source Health Technology Assessment (Winchester, England). 22(38):1-144, 2018 Jul. VI 1 Status In-Data-Review Authors Ramsay CR; Clarkson JE; Duncan A; Lamont TJ; Heasman PA; Boyers D; Goulao B; Bonetti D; Bruce R; Gouick J; Heasman L; Lovelock-Hempleman LA; Macpherson LE; McCracken GI; McDonald AM; McLaren-Neil F; Mitchell FE; Norrie JD; van der Pol M; Sim K; Steele JG; Sharp A; Watt G; Worthington HV; Young L. Authors Full Name Ramsay, Craig R; Clarkson, Jan E; Duncan, Anne; Lamont, Thomas J; Heasman, Peter A; Boyers, Dwayne; Goulao, Beatriz; Bonetti, Debbie; Bruce, Rebecca; Gouick, Jill; Heasman, Lynne; Lovelock-Hempleman, Laura A; Macpherson, Lorna E; McCracken, Giles I; McDonald, Alison M; McLaren-Neil, Fiona; Mitchell, Fiona E; Norrie, John Dt; van der Pol, Marjon; Sim, Kirsty; Steele, James G; Sharp, Alex; Watt, Graeme; Worthington, Helen V; Young, Linda. Institution Ramsay, Craig R. Health Services Research Unit, University of Aberdeen, Aberdeen, UK. Clarkson, Jan E. Dental Health Services Research Unit, University of Dundee, Dundee, UK. Duncan, Anne. Health Services Research Unit, University of Aberdeen, Aberdeen, UK. Lamont, Thomas J. Dundee Dental School, University of Dundee, Dundee, UK. Heasman, Peter A. The Dental School, Newcastle University, Newcastle upon Tyne, UK. Boyers, Dwayne. Health Economics Research Unit, University of Aberdeen, Aberdeen, UK. Goulao, Beatriz. Health Services Research Unit, University of Aberdeen, Aberdeen, UK. Bonetti, Debbie. Dental Health Services Research Unit, University of Dundee, Dundee, UK. Bruce, Rebecca. Health Services Research Unit, University of Aberdeen, Aberdeen, UK. Gouick, Jill. Dental Health Services Research Unit, University of Dundee, Dundee, UK. Heasman, Lynne. The Dental School, Newcastle University, Newcastle upon Tyne, UK. Lovelock-Hempleman, Laura A. Dental Health Services Research Unit, University of Dundee, Dundee, UK. Macpherson, Lorna E. Dental Health Services Research Unit, University of Dundee, Dundee, UK. McCracken, Giles I. The Dental School, Newcastle University, Newcastle upon Tyne, UK. McDonald, Alison M. Health Services Research Unit, University of Aberdeen, Aberdeen, UK. McLaren-Neil, Fiona. Dental Health Services Research Unit, University of Dundee, Dundee, UK. Mitchell, Fiona E. Dental Health Services Research Unit, University of Dundee, Dundee, UK.

Norrie, John Dt. Health Services Research Unit, University of Aberdeen, Aberdeen, UK. van der Pol, Marjon. Health Economics Research Unit, University of Aberdeen, Aberdeen, UK. Sim, Kirsty. Dental Health Services Research Unit, University of Dundee, Dundee, UK. Steele, James G. The Dental School, Newcastle University, Newcastle upon Tyne, UK. Sharp, Alex. The Dental School, Newcastle University, Newcastle upon Tyne, UK. Watt, Graeme. Dental Health Services Research Unit, University of Dundee, Dundee, UK. Worthington, Helen V. The School of Dentistry, University of Manchester, Manchester, UK. Young, Linda. NHS Education for Scotland, Edinburgh, UK. Abstract BACKGROUND: Periodontal disease is preventable but remains the most common oral disease worldwide, with major health and economic implications. Stakeholders lack reliable evidence of the relative clinical effectiveness and cost-effectiveness of different types of oral hygiene advice (OHA) and the optimal frequency of periodontal instrumentation (PI). OBJECTIVES: To test clinical effectiveness and assess the economic value of the following strategies: personalised OHA versus routine OHA, 12-monthly PI (scale and polish) compared with 6-monthly PI, and no PI compared with 6-monthly PI. DESIGN: Multicentre, pragmatic split-plot, randomised open trial with a cluster factorial design and blinded outcome evaluation with 3 years' follow-up and a within-trial cost-benefit analysis. NHS and participant costs were combined with benefits [willingness to pay (WTP)] estimated from a discrete choice experiment (DCE). SETTING: UK dental practices. PARTICIPANTS: Adult dentate NHS patients, regular attenders, with Basic Periodontal Examination (BPE) scores of 0, 1, 2 or 3. INTERVENTION: Practices were randomised to provide routine or personalised OHA. Within each practice, participants were randomised to the following groups: no PI, 12-monthly PI or 6-monthly PI (current practice). MAIN OUTCOME MEASURES: Clinical - gingival inflammation/bleeding on probing at the gingival margin (3 years). Patient - oral hygiene self-efficacy (3 years). Economic - net benefits (mean WTP minus mean costs). RESULTS: A total of 63 dental practices and 1877 participants were recruited. The mean number of teeth and percentage of bleeding sites was 24 and 33%, respectively. Two-thirds of participants had BPE scores of <= 2. Under intention-to-treat analysis, there was no evidence of a difference in gingival inflammation/bleeding between the 6-monthly PI group and the no-PI group [difference 0.87%, 95% confidence interval (CI) -1.6% to 3.3%; p=0.481] or between the 6-monthly PI group and the 12-monthly PI group (difference 0.11%, 95% CI -2.3% to 2.5%; p=0.929). There was also no evidence of a difference between personalised and routine OHA (difference -2.5%, 95% CI -8.3% to 3.3%; p=0.393). There was no evidence of a difference in self-efficacy between the 6-monthly PI group and the no-PI group (difference -0.028, 95% CI -0.119 to 0.063; p=0.543) and no evidence of a clinically important difference between the 6-monthly PI group and the 12-monthly PI group (difference -0.097, 95% CI -0.188 to -0.006; p=0.037). Compared with standard care, no PI with personalised OHA had the greatest cost savings: NHS perspective -15 (95% CI -34 to 4) and participant perspective -64 (95% CI -112 to -16). The DCE shows that the general population value these services greatly. Personalised OHA with 6-monthly PI had the greatest incremental net benefit [48 (95% CI 22 to 74)]. Sensitivity analyses did not change conclusions. LIMITATIONS: Being a pragmatic trial, we did not deny PIs to the no-PI group; there was clear separation in the mean number of PIs between groups. CONCLUSIONS: There was no additional benefit from scheduling 6-monthly or 12-monthly PIs over not providing this treatment unless desired or recommended, and no difference between OHA delivery for gingival inflammation/bleeding and patient-centred outcomes. However, participants valued, and were willing to pay for, both interventions, with greater financial value placed on PI than on OHA. FUTURE WORK: Assess the clinical effectiveness and cost-effectiveness of providing multifaceted periodontal care packages in primary dental care for those with periodontitis. TRIAL REGISTRATION: Current Controlled Trials ISRCTN56465715. FUNDING: This project was funded by the National Institute for Health Research (NIHR) Health Technology Assessment programme and will be published in full in Health Technology Assessment; Vol. 22, No. 38. See the NIHR Journals Library website for further project information. Publication Type Clinical Trial. Year of Publication 2018 <72> Unique Identifier 29991907 Title Efficacy of metformin in the management of periodontitis: A systematic review and meta-analysis. [Review] Source Saudi Pharmaceutical Journal. 26(5):634-642, 2018 Jul. VI 1 Status PubMed-not-MEDLINE Authors

Najeeb S; Zafar MS; Khurshid Z; Zohaib S; Madathil SA; Mali M; Almas K. Authors Full Name Najeeb, Shariq; Zafar, Muhammad Sohail; Khurshid, Zohaib; Zohaib, Sana; Madathil, Sreenath Arekunnath; Mali, Maria; Almas, Khalid. Institution Najeeb, Shariq. Restorative Dental Sciences, Al-Farabi Colleges, King Abdullah Road, Riyadh, Saudi Arabia. Zafar, Muhammad Sohail. Department of Restorative Dentistry, College of Dentistry, Taibah University, Madinah Al Munawwarah, Saudi Arabia. Zafar, Muhammad Sohail. Department of Dental Materials, Islamic International Dental College, Riphah International University, Islamabad, Pakistan. Khurshid, Zohaib. Department of Biomaterials and Prosthodontics, College of Dentistry, King Faisal University, Al Hofuf, Saudi Arabia. Zohaib, Sana. Department of Biomedical Engineering, School of Engineering, King Faisal University, Al Hofuf, Saudi Arabia. Madathil, Sreenath Arekunnath. Division of Oral Health and Society Research, Faculty of Dentistry, McGill University, 2001 McGill College Ave, Montreal, Quebec, Canada. Mali, Maria. Department of Orthodontics, Islamic International Dental College, Ripah International University, Islamabad 44000, Pakistan. Almas, Khalid. Department of Preventive Dental Sciences, College of Dentistry, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia. Abstract Periodontitis is characterized by inflammation of the periodontium and leads to loss of teeth if untreated. Although a number of surgical and pharmacological options are available for the management of periodontitis, it still affects a large proportion of population. Recently, metformin (MF), an oral hypoglycemic, has been used to treat periodontitis. The aim of this review is to systematically evaluate the efficacy of MF in the treatment of periodontitis. An electronic search was carried out using the keywords 'metformin', 'periodontal' and 'periodontitis' via the PubMed/Medline, ISI Web of Science and Google Scholar databases for relevant articles published from 1949 to 2016. The addressed focused question was: 'Is metformin effective in reducing bone loss in periodontitis? Critical review and meta-analysis were conducted of the results obtained in the selected studies. Following the removal of the duplicate results, the primary search resulted in 17 articles and seven articles were excluded based on title and abstract. Hence, 10 articles were read completely for eligibility. After exclusion of four irrelevant studies, six articles were included. The topical application of MF resulted in improved histological, clinical and radiographic outcomes. Additionally, results from the meta-analysis indicated that application of metformin improved the clinical and radiographic outcomes of scaling and root-planing, but at the same time heterogeneity was evident among the results. However, because of a lack of histological and bacterial studies, in addition to short follow-up periods and risk of bias, the long-term efficacy of MF in the treatment of bony defects is not yet ascertained. Further studies are needed to envisage the long-term efficacy of MF in the management of periodontitis. Publication Type Journal Article. Review. Year of Publication 2018 <73> Unique Identifier 29516510 Title Integrated analysis of long noncoding RNA-associated competing endogenous RNA network in periodontitis. Source Journal of Periodontal Research. 53(4):495-505, 2018 Aug. VI 1 Status In-Process Authors Li S; Liu X; Li H; Pan H; Acharya A; Deng Y; Yu Y; Haak R; Schmidt J; Schmalz G; Ziebolz D. Author NameID Acharya, A; ORCID: http://orcid.org/0000-0002-9319-6780 Ziebolz, D; ORCID: http://orcid.org/0000-0002-9810-2368 Authors Full Name Li, S; Liu, X; Li, H; Pan, H; Acharya, A; Deng, Y; Yu, Y; Haak, R; Schmidt, J; Schmalz, G; Ziebolz, D. Institution Li, S. Department of Cariology, Endodontology and Periodontology, University of Leipzig, Leipzig, Germany. Liu, X. Shanghai Genomap Technologies, Yangpu District, Shanghai, China. Liu, X. College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, Heilongjiang Province, China. Li, H. Saxon Incubator for Clinical Translation (SIKT), University of Leipzig, Leipzig, Germany. Pan, H. Department of Orthopedic Surgery, Brigham and Women's Hospital, Harvard Medical School, Harvard University, Boston, MA, USA. Acharya, A. Faculty of Dentistry, University of Hong Kong, Hong Kong, China. Acharya, A. Dr D Y Patil Dental College and Hospital, Dr D Y Patil Vidyapeeth, Pimpri, Pune, India. Deng, Y. Shanghai Genomap Technologies, Yangpu District, Shanghai, China. Yu, Y. Department of Periodontology, The Stomatology Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang Province, China. Haak, R. Department of Cariology, Endodontology and Periodontology, University of Leipzig, Leipzig, Germany. Schmidt, J. Department of Cariology, Endodontology and Periodontology, University of Leipzig, Leipzig, Germany. Schmalz, G. Department of Cariology, Endodontology and Periodontology, University of Leipzig, Leipzig, Germany. Ziebolz, D. Department of Cariology, Endodontology and Periodontology, University of Leipzig, Leipzig, Germany. Local Messages THIS JOURNAL IS AVAILABLE IN THE BDA LIBRARY, TO REQUEST THIS ARTICLE FROM THE LIBRARY GO TO: https://www.bda.org/library/journals-articles/Documents/photocopy-request-form.pdf

Abstract BACKGROUND AND OBJECTIVES: Long noncoding RNAs (lncRNAs) play critical and complex roles in regulating various biological processes of periodontitis. This bioinformatic study aims to construct a putative competing endogenous RNA (ceRNA) network by integrating lncRNA, miRNA and mRNA expression, based on high-throughput RNA sequencing and microarray data about periodontitis. MATERIAL AND METHODS: Data from 1 miRNA and 3 mRNA expression profiles were obtained to construct the lncRNA-associated ceRNA network. Gene Ontology enrichment analysis and pathway analysis were performed using the Gene Ontology website and Kyoto Encyclopedia of Genes and Genomes. A protein-protein interaction network was constructed based on the Search Tool for the retrieval of Interacting Genes/Proteins. Transcription factors (TFs) of differentially expressed genes were identified based on TRANSFAC database and then a regulatory network was constructed. RESULTS: Through constructing the dysregulated ceRNA network, 6 genes (HSPA4L, PANK3, YOD1, CTNNBIP1, EVI2B, ITGAL) and 3 miRNAs (miR-125a-3p, miR-200a, miR-142-3p) were detected. Three lncRNAs (MALAT1, TUG1, FGD5-AS1) were found to target both miR-125a-3p and miR-142-3p in this ceRNA network. Protein-protein interaction network analysis identified several hub genes, including VCAM1, ITGA4, UBC, LYN and SSX2IP. Three pathways (cytokine-cytokine receptor, cell adhesion molecules, chemokine signaling pathway) were identified to be overlapping results with the previous bioinformatics studies in periodontitis. Moreover, 2 TFs including FOS and EGR were identified to be involved in the regulatory network of the differentially expressed genes-TFs in periodontitis. CONCLUSION: These findings suggest that 6 mRNAs (HSPA4L, PANK3, YOD1, CTNNBIP1, EVI2B, ITGAL), 3 miRNAs (hsa-miR-125a-3p, hsa-miR-200a, hsa-miR-142-3p) and 3 lncRNAs (MALAT1, TUG1, FGD5-AS1) might be involved in the lncRNA-associated ceRNA network of periodontitis. This study sought to illuminate further the genetic and epigenetic mechanisms of periodontitis through constructing an lncRNA-associated ceRNA network. Copyright © 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. Publication Type Journal Article. Year of Publication 2018 <74> Unique Identifier 29980169 Title Association between periodontitis and peripheral artery disease: a systematic review and meta-analysis. Source BMC Cardiovascular Disorders. 18(1):141, 2018 Jul 06. VI 1 Status In-Data-Review Authors Yang S; Zhao LS; Cai C; Shi Q; Wen N; Xu J. Author NameID Xu, Juan; ORCID: http://orcid.org/0000-0003-1381-3580 Authors Full Name Yang, Shuo; Zhao, Li Sheng; Cai, Chuan; Shi, Quan; Wen, Ning; Xu, Juan. Institution Yang, Shuo. Department of Stomatology, Chinese People's Liberation Army General Hospital, 28 Fuxing Road, Beijing, 100853, China. Zhao, Li Sheng. Department of Stomatology, Chinese People's Liberation Army General Hospital, 28 Fuxing Road, Beijing, 100853, China. Cai, Chuan. Department of Stomatology, Chinese People's Liberation Army General Hospital, 28 Fuxing Road, Beijing, 100853, China. Shi, Quan. Department of Stomatology, Chinese People's Liberation Army General Hospital, 28 Fuxing Road, Beijing, 100853, China. Wen, Ning. Department of Stomatology, Chinese People's Liberation Army General Hospital, 28 Fuxing Road, Beijing, 100853, China. [email protected]. Xu, Juan. Department of Stomatology, Chinese People's Liberation Army General Hospital, 28 Fuxing Road, Beijing, 100853, China. [email protected]. Abstract BACKGROUND: Inflammation is a common feature of both peripheral arterial disease (PAD) and periodontitis. Some studies have evaluated the association between PAD and periodontitis. However, there is still no specialized meta-analysis that has quantitatively assessed the strength of the association. Thus, we conducted this meta-analysis to critically assess the strength of the association between PAD and periodontitis. METHODS: PubMed, Embase, and the Cochrane Library were searched for observational studies of the association between periodontitis and PAD in February 2018. Risk ratios (RRs) and their 95% confidence intervals (CIs) from included studies were pooled to evaluate the strength of the association between periodontitis and PAD. Weighted mean differences (WMDs) and their 95% CIs were pooled to compare the difference in periodontal-related parameters between PAD and non-PAD patients. RESULTS: Seven studies including a total of 4307 participants were included in the meta-analysis. The pooled analysis showed that there was a significant difference in the risk of periodontitis between PAD patients and non-PAD participants (RR=1.70, 95% CI=1.25-2.29, P=0.01). There was also a significant difference in number of missing teeth between PAD patients and non-PAD

participants (WMD=3.75, 95% CI=1.31-6.19, P=0.003). No significant difference was found in clinical attachment loss between PAD patients and non-PAD participants (WMD=-0.05, 95% CI=-0.03-0.19, P=0.686). CONCLUSION: In conclusion, the results of this meta-analysis revealed a significant relationship between periodontitis and PAD. Moreover, our study indicated that PAD patients had more missing teeth than control subjects did. Further high-quality and well-designed studies with specific inclusion and exclusion criteria are required to strengthen the conclusions of this study. Publication Type Journal Article. Year of Publication 2018 <75> Unique Identifier 29977919 Title Efficacy of Adjunctive Bioactive Materials in the Treatment of Periodontal Intrabony Defects: A Systematic Review and Meta-Analysis. [Review] Source BioMed Research International. 2018:8670832, 2018. VI 1 Status In-Process Authors Zhou S; Sun C; Huang S; Wu X; Zhao Y; Pan C; Wang H; Liu J; Li Q; Kou Y. Author NameID Pan, Chunling; ORCID: https://orcid.org/0000-0002-3835-9719 Wang, Hongyan; ORCID: https://orcid.org/0000-0003-4745-2760 Kou, Yurong; ORCID: https://orcid.org/0000-0003-0249-4481 Authors Full Name Zhou, Shuai; Sun, Chengjia; Huang, Shaohui; Wu, Ximing; Zhao, Yan; Pan, Chunling; Wang, Hongyan; Liu, Junchao; Li, Qian; Kou, Yurong. Institution Zhou, Shuai. Department of Periodontology, School of Stomatology, China Medical University, Shenyang, Liaoning 110002, China. Sun, Chengjia. Department of Oral Biology, School of Stomatology, China Medical University, Shenyang, Liaoning 110002, China. Huang, Shaohui. Department of Oral and Maxillofacial Surgery, School of Stomatology, China Medical University, Shenyang, Liaoning 110002, China. Wu, Ximing. Department of Oral Biology, School of Stomatology, China Medical University, Shenyang, Liaoning 110002, China. Zhao, Yan. Department of Periodontology, School of Stomatology, China Medical University, Shenyang, Liaoning 110002, China. Pan, Chunling. Department of Periodontology, School of Stomatology, China Medical University, Shenyang, Liaoning 110002, China. Wang, Hongyan. Department of Periodontology, School of Stomatology, China Medical University, Shenyang, Liaoning 110002, China. Liu, Junchao. Department of Periodontology, School of Stomatology, China Medical University, Shenyang, Liaoning 110002, China. Li, Qian. Department of Oral Biology, School of Stomatology, China Medical University, Shenyang, Liaoning 110002, China. Kou, Yurong. Department of Periodontology, School of Stomatology, China Medical University, Shenyang, Liaoning 110002, China. Kou, Yurong. Department of Oral Biology, School of Stomatology, China Medical University, Shenyang, Liaoning 110002, China. Abstract Objectives: Lots of bioactive materials have been additionally applied for the treatment of periodontal intrabony defect. However, there is dearth of studies to systematically evaluate the supplementary role of them in periodontal regeneration. The goal of this meta-analysis is to evaluate the adjunctive effects of bioactive materials such as platelet-rich plasma (PRP), platelet-rich fibrin (PRF), enamel matrix derivative (EMD), and amnion membrane (AM) on the outcomes of bone grafting treatment for periodontal intrabony defects. Methods: Articles published before December 2017 were searched electronically in three databases (PubMed, Embase, and Cochrane Central), with no date or language limits. Randomized controlled trials (RCTs) on the assessment of effectiveness of the four biomaterials in conjunction with demineralized freeze-dried bone allografts (DFDBA) in the treatment of periodontal intrabony defects were enrolled in this meta-analysis. Data were analyzed with STATA 12. Results: Nine studies were included. PRF and PRP significantly improved pocket depth (PD) reduction and clinical attachment loss (CAL) gain. Only PRF exhibited a positive result in recession reduction (RecRed). Only PRP showed a statistically significant increase in bone fill. AM merely gained more CAL. EMD did not improve any clinical outcome. Conclusion: Our data suggest that PRF/PRP could be taken as a preferred adjunct to facilitate periodontal regeneration of intrabony defects. Publication Type Journal Article. Review. Year of Publication 2018 <76>

Unique Identifier 29963478 Title Comparison of conventional imaging techniques and CBCT for periodontal evaluation: A systematic review. [Review] Source Imaging Science in Dentistry. 48(2):79-86, 2018 Jun. VI 1 Status PubMed-not-MEDLINE Authors Choi IGG; Cortes ARG; Arita ES; Georgetti MAP. Authors Full Name Choi, Isabela Goulart Gil; Cortes, Arthur Rodriguez Gonzalez; Arita, Emiko Saito; Georgetti, Marco Antonio Pauperio. Institution Choi, Isabela Goulart Gil. Department of Oral Radiology, School of Dentistry, University of Sao Paulo, Sao Paulo, SP, Brazil. Cortes, Arthur Rodriguez Gonzalez. Department of Oral Radiology, School of Dentistry, University of Sao Paulo, Sao Paulo, SP, Brazil. Arita, Emiko Saito. Department of Oral Radiology, School of Dentistry, University of Sao Paulo, Sao Paulo, SP, Brazil. Georgetti, Marco Antonio Pauperio. Department of Periodontics, School of Dentistry, University of Sao Paulo, Sao Paulo, SP, Brazil. Abstract Purpose: This study aimed to carry out a systematic review of studies in the literature comparing conventional imaging techniques with cone-beam computed tomography in terms of the role of these techniques for assessing any of the following periodontal conditions and parameters: infrabony defects, furcation involvement, height of the alveolar bone crest, and the periodontal ligament space. Materials and Methods: Interventional and observational studies comparing conventional imaging techniques with cone-beam computed tomography were considered eligible for inclusion. The MEDLINE and Embase databases were searched for articles published through 2017. The PRISMA statement was followed during data assessment and extraction. Results: The search strategy yielded 351 publications. An initial screening of the publications was performed using abstracts and key words, and after the application of exclusion criteria, 13 studies were finally identified as eligible for review. Conclusion: These studies revealed cone-beam computed tomography to be the best imaging technique to assess infrabony defects, furcation lesions, the height of the alveolar bone crest, and the periodontal ligament space. Publication Type Journal Article. Review. Year of Publication 2018 <77> Unique Identifier 29951095 Title Corrigendum to "Biological Effects of Medicinal Plants on Induced Periodontitis: A Systematic Review".[Erratum for Int J Dent. 2016;2016:3719879; PMID: 27738432] Source International Journal of Dentistry. 2018:5656189, 2018. VI 1 Status In-Data-Review Authors Soares de Oliveira J; Conceicao Pinto MES; Santana LAB; Pinto ASB; Lenardo DD; Vasconcelos DFP. Author NameID Soares de Oliveira, Jefferson; ORCID: https://orcid.org/0000-0003-4192-8238 Santana, Lucas de Araujo de Bastos; ORCID: https://orcid.org/0000-0002-8276-2521 Pinto, Antonione Santos Bezerra; ORCID: https://orcid.org/0000-0002-6577-2816 Vasconcelos, Daniel Fernando Pereira; ORCID: https://orcid.org/0000-0002-3331-452X Authors Full Name Soares de Oliveira, Jefferson; Conceicao Pinto, Moara E Silva; Santana, Lucas de Araujo de Bastos; Pinto, Antonione Santos Bezerra; Lenardo, David di; Vasconcelos, Daniel Fernando Pereira. Institution Soares de Oliveira, Jefferson. Laboratory of Biology and Biochemistry Plants (BIOqPLANT), Federal University of Piaui, Parnaiba, PI, Brazil. Conceicao Pinto, Moara E Silva. Laboratory of Histological Analysis and Prepare (LAPHIS), Federal University of Piaui, Parnaiba, PI, Brazil. Santana, Lucas de Araujo de Bastos. Laboratory of Biology and Biochemistry Plants (BIOqPLANT), Federal University of Piaui, Parnaiba, PI, Brazil. Pinto, Antonione Santos Bezerra. Department of Morphology, LABICONTE, Federal University of Ceara, Fortaleza, CE, Brazil. Lenardo, David di. Laboratory of Biology and Biochemistry Plants (BIOqPLANT), Federal University of Piaui, Parnaiba, PI, Brazil. Vasconcelos, Daniel Fernando Pereira. Laboratory of Histological Analysis and Prepare (LAPHIS), Federal University of Piaui, Parnaiba, PI, Brazil. Abstract [This corrects the article DOI: 10.1155/2016/3719879.]. Publication Type

Published Erratum. Year of Publication 2018 <78> Unique Identifier 29779565 Title Periodontal disease in patients with Down syndrome: A systematic review. [Review] Source Journal of the American Dental Association. 149(7):628-639.e11, 2018 Jul. VI 1 Status In-Data-Review Authors Scalioni FAR; Carrada CF; Martins CC; Ribeiro RA; Paiva SM. Authors Full Name Scalioni, Flavia Almeida Ribeiro; Carrada, Camila Faria; Martins, Carolina Castro; Ribeiro, Rosangela Almeida; Paiva, Saul Martins. Local Messages THIS JOURNAL IS AVAILABLE IN THE BDA LIBRARY, BDA MEMBERS CAN ALSO ACCESS THIS JOURNAL ONLINE FROM 1995 TO DATE. Go to www.bda.org/ejournals Abstract BACKGROUND: The authors systematically reviewed the scientific evidence of an association between periodontal disease and Down syndrome (DS). TYPES OF STUDIES REVIEWED: In this systematic review, the authors included observational studies in which the investigators assessed the prevalence, incidence, or experience of periodontal disease in patients with DS compared with that in healthy patients. The authors used the Population, Exposure, Comparison, Outcome structure. The population was patients of any age, the exposure was the presence of DS, the comparison was the absence of DS, and the outcome was the presence of periodontal disease. The authors conducted an electronic search in 5 databases through March 2017. Two independent reviewers assessed the risk of bias by using the Fowkes and Fulton scale. The authors performed a meta-analysis to compare periodontal disease among patients with DS and those without DS. The authors calculated a summary effect measure-standard mean difference-when evaluating the means of the oral hygiene index. The authors assessed the strength of evidence from the selected studies by using a modified Grading of Recommendations Assessment, Development and Evaluation system. RESULTS: The authors included 23 case-control studies in the systematic review and submitted 3 to meta-analysis. In the qualitative analysis, results from most studies showed that the prevalence of some periodontal parameters was higher among patients with DS than among those without DS. Evaluations of the Fowkes and Fulton scale point to many methodological problems in the studies evaluated. Results of the meta-analysis revealed no differences between groups with regard to the oral hygiene index (standard mean difference, 0.05; 95% confidence interval, -0.55 to 0.65; I2 = 0.0%). CONCLUSIONS AND PRACTICAL IMPLICATIONS: Further research is required, in particular well-designed studies that avoid the deficiencies identified in the studies in this review. Copyright © 2018 American Dental Association. Published by Elsevier Inc. All rights reserved. Publication Type Journal Article. Review. Year of Publication 2018 <79> Unique Identifier 29922333 Title Association of vitamin D receptor BsmI, TaqI, FokI, and ApaI polymorphisms with susceptibility of chronic periodontitis: A systematic review and meta-analysis based on 38 case -control studies. [Review] Source Dental Research Journal. 15(3):155-165, 2018 May-Jun. VI 1 Status PubMed-not-MEDLINE Authors Mashhadiabbas F; Neamatzadeh H; Nasiri R; Foroughi E; Farahnak S; Piroozmand P; Mazaheri M; Zare-Shehneh M. Authors Full Name Mashhadiabbas, Fatemeh; Neamatzadeh, Hossein; Nasiri, Rezvan; Foroughi, Elnaz; Farahnak, Soudabeh; Piroozmand, Parisa; Mazaheri, Mahta; Zare-Shehneh, Masoud. Institution Mashhadiabbas, Fatemeh. Department of Oral and Maxillofacial Pathology, Dental School, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Neamatzadeh, Hossein. Department of Medical Genetics, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. Neamatzadeh, Hossein. Mother and Newborn Health Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. Nasiri, Rezvan. Departments of Restorative and Esthetic, Arak University of Medical Science, Arak, Iran. Foroughi, Elnaz. Pediatric Dentistry, Arak University of Medical Science, Arak, Iran.

Farahnak, Soudabeh. Endodontics, Dental School, Arak University of Medical Science, Arak, Iran. Piroozmand, Parisa. Department of Oral and Maxillofacial Medicine, Dental School, Ardabil University of Medical Science, Ardabil, Iran. Mazaheri, Mahta. Department of Medical Genetics, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. Mazaheri, Mahta. Mother and Newborn Health Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. Zare-Shehneh, Masoud. Department of Medical Genetics, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. Abstract Background: There has been increasing interest in the study of the association between Vitamin D receptor (VDR) gene polymorphisms and risk of chronic periodontitis. However, the results remain inconclusive. To better understand the roles of VDR polymorphisms (BsmI, TaqI, FokI, and ApaI) in chronic periodontitis susceptibility, we conducted this systematic review and meta-analysis. Materials and Methods: The PubMed, Google Scholar, and Web of Science database were systemically searched to determine all the eligible studies about VDR polymorphisms and risk of chronic periodontitis up to April 2017. Odds ratio (OR) and 95% confidence interval (CI) were used to evaluate the associations between VDR polymorphisms and chronic periodontitis risk. All the statistical analyses were performed by Comprehensive Meta-Analysis. All P values were two-tailed with a significant level at 0.05. Results: Finally, a total of 38 case-control studies in 19 publications were identified which met our inclusion criteria. There are ten studies with 866 chronic periodontitis cases and 786 controls for BsmI, 16 studies with 1570 chronic periodontitis cases and 1676 controls for TaqI, five studies with 374 chronic periodontitis cases and 382 controls for FokI, and seven studies with 632 chronic periodontitis cases and 604 controls for ApaI. Overall, no significant association was observed between VDR gene BsmI, TaqI, FokI, and ApaI polymorphisms and risk of chronic periodontitis in any genetic model. Subgroup analysis stratified by ethnicity suggested a significant association between BsmI polymorphism and chronic periodontitis risk in the Caucasian subgroup under allele model (A vs. G: OR = 1.747, 95% CI = 1.099-2.778, P = 0.018). Further, no significant associations were observed when stratified by Hardy-Weinberg equilibrium status for BsmI, TaqI, and ApaI. Conclusion: Our results suggest that BsmI, TaqI, FokI, and ApaI polymorphisms in the VDR gene might not be associated with risk of chronic periodontitis in overall population. Publication Type Journal Article. Review. Year of Publication 2018 <80> Unique Identifier 29915637 Title Denture-Associated Oral Microbiome and Periodontal Disease Causing an Anaerobic Pyogenic Liver Abscess in an Immunocompetent Patient: A Case report and Review of the Literature. Source Gastroenterology Research. 11(3):241-246, 2018 Jun. VI 1 Status PubMed-not-MEDLINE Authors Hammami MB; Noonan EM; Chhaparia A; Khatib FA; Bassuner J; Hachem C. Authors Full Name Hammami, Muhammad Bader; Noonan, Elizabeth M; Chhaparia, Anuj; Khatib, Feras Al; Bassuner, Juri; Hachem, Christine. Institution Hammami, Muhammad Bader. Department of Internal Medicine, Division of Gastroenterology and Hepatology, Saint Louis University School of Medicine, St Louis, MO, USA. Noonan, Elizabeth M. Department of Pediatrics, Saint Louis University School of Medicine, Saint Louis, MO, USA. Chhaparia, Anuj. Department of Internal Medicine, Saint Louis University School of Medicine, Saint Louis, MO, USA. Khatib, Feras Al. Southern Illinois University, School of Dental Medicine, Alton, IL, USA. Bassuner, Juri. Department of Radiology, Saint Louis University School of Medicine, Saint Louis, MO, USA. Hachem, Christine. Department of Internal Medicine, Division of Gastroenterology and Hepatology, Saint Louis University School of Medicine, St Louis, MO, USA. Abstract Pyogenic liver abscesses (PLA) develop from the spread of infection through the portal circulation, biliary infections or arterial hematogenous seeding in the setting of systemic infections. PLA are often poly-microbial and are uncommonly reported to be due to anaerobic species. We report the case of a previously healthy, immunocompetent 63-year-old man with hepatic abscesses as a result of Fusobacterium nucleatum periodontal disease. In addition, a systemic review of the literature is performed. Fusobacterium is a very rare cause of PLA in immunocompetent hosts with only a handful of cases reported in the literature. Although anaerobic infections such as Fusobacterium most often occur in immunocompromised individuals, clinicians should have a high index of suspicion in immunocompetent patients with periodontal disease or chronic stomatitis. Publication Type Journal Article. Year of Publication 2018 <81> Unique Identifier 29911043 Title Polycystic Ovary Syndrome and Periodontal disease: Underlying Links- A Review. [Review]

Source Indian Journal of Endocrinology and Metabolism. 22(2):267-273, 2018 Mar-Apr. VI 1 Status PubMed-not-MEDLINE Authors Tanguturi SC; Nagarakanti S. Authors Full Name Tanguturi, Sri Chandana; Nagarakanti, Sreenivas. Institution Tanguturi, Sri Chandana. Department of Periodontology, Narayana Dental College and Hospital, Nellore, Andhra Pradesh, India. Nagarakanti, Sreenivas. Department of Periodontology, Narayana Dental College and Hospital, Nellore, Andhra Pradesh, India. Abstract Polycystic ovary syndrome (PCOS) is the most common endocrine disorder among women of reproductive age, which negatively affects various health systems. There is an extensive literature regarding the association of PCOS and other systemic conditions such as diabetes mellitus, cardiovascular disease, and psychological disorders. However, there is a lack of literature in associating PCOS and periodontal disease. Hence, PubMed search was done for various articles related to PCOS and its association with other comorbidities, including periodontal diseases. Analysis was done and data were synthesized and compiled in a sequential and presentable paradigm. This literature review of the pathophysiological mechanisms linking the two diseases suggests a positive relation between the two comorbidities. However, multicenter studies, with larger sample sizes, are to be conducted to establish a clearer and stronger association. Publication Type Journal Article. Review. Year of Publication 2018 <82> Unique Identifier 28152316 Title n-3 Ingestion may modulate the severity of periodontal disease? Systematic review. Source Critical Reviews in Food Science & Nutrition. 58(11):1937-1942, 2018 Jul 24. VI 1 Status In-Process Authors Azzi DV; Viafara JAS; Zangeronimo MG; Ribeiro Lima R; Marques LS; Pereira LJ. Author NameID Pereira, Luciano J; ORCID: http://orcid.org/0000-0002-0502-2554 Authors Full Name Azzi, Diana Vilela; Viafara, Jesus Alfonso Sanchez; Zangeronimo, Marcio Gilberto; Ribeiro Lima, Renato; Marques, Leandro Silva; Pereira, Luciano J. Institution Azzi, Diana Vilela. a Veterinary Medicine Graduate Program , Federal University of Lavras, UFLA-Lavras , Minas Gerais , Brazil. Viafara, Jesus Alfonso Sanchez. a Veterinary Medicine Graduate Program , Federal University of Lavras, UFLA-Lavras , Minas Gerais , Brazil. Zangeronimo, Marcio Gilberto. b Veterinary Medicine Departament , Federal University of Lavras, UFLA - Lavras , Minas Gerais , Brazil. Ribeiro Lima, Renato. c Statistics Department , Federal University of Lavras, UFLA - Lavras , Minas Gerais , Brazil. Marques, Leandro Silva. d Dentistry Department , Federal University of Vale do Jequitinhonha e Mucuri, UFVJM - Diamantina , Minas Gerais , Brazil. Pereira, Luciano J. e Health Sciences Department , Federal University of Lavras, UFLA - Lavras , Minas Gerais , Brazil. Abstract The aim of this study was to determine the effects of n-3 ingestion on periodontal disease. Besides, we also investigated the relationship between plasma concentrations of eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), and/or aracdonic acid (AA), and periodontal disease. An electronic search was performed in several databases with the following keywords: "n-3," DHA, EPA and polynsaturated fatty acids (PUFA) in combination with the term "periodontal disease" (PD). Only studies conducted with humans, involving clinical parameters of PD assessment and use of n-3 were selected, without restriction to the date of publication. The search has returned 1368 articles, 11 of which were selected. The results were separated according to the type of n-3 ingestion: supplementation or n-3 content in normal diet. In the studies where n-3 has been supplemented, there was no significant difference in the clinical severity of PD compared to the control subjects. However, in patients where levels of n-3 were evaluated in a usual diet, a lower disease severity was reported. We have detected a preventive effect related to plasma levels of EPA and DHA against PD progression. Thus, n-3 ingestion may beneficially interfere in PD progression, depending on the duration and dosage of consumption. Publication Type Journal Article. Year of Publication 2018 <83> Unique Identifier 29892530 Title A systematic review of biomarkers of gingival crevicular fluid: Their predictive role in diagnosis of periodontal disease status.

Source Journal of Oral Biology & Craniofacial Research. 8(2):98-104, 2018 May-Aug. VI 1 Status PubMed-not-MEDLINE Authors Gupta S; Chhina S; Arora SA. Authors Full Name Gupta, Stuti; Chhina, Shivjot; Arora, Sachit Anand. Institution Gupta, Stuti. I.T.S. Dental College, Hospital and Research Centre, Knowledge Park 3, Greater Noida, Uttar Pradesh, 201308, India. Chhina, Shivjot. I.T.S. Dental College, Hospital and Research Centre, Knowledge Park 3, Greater Noida, Uttar Pradesh, 201308, India. Arora, Sachit Anand. I.T.S. Dental College, Hospital and Research Centre, Knowledge Park 3, Greater Noida, Uttar Pradesh, 201308, India. Abstract The objective of the study was to conduct a systematic review of the literature so as to evaluate and summarize the diagnostic and prognostic potential of GCF. Included studies were systematically analyzed based on PRISMA (Preferred Reporting Items For Systematic Reviews and Meta Analyses) and studies were identified based on the-PICO (Glossary of evidence based terms 2007): 1)Patients with chronic periodontitis.2)Intervention- NSPT (Non-SurgicalPeriodontal therapy); NSPT + Chemotherapeutics.3)Comparison between treated v/s non treated sites.4)Outcomes measured: Analysis of variation in constituents of GCF. Electronic database search of Pubmed, Medline, Google Scholar and Scopus was performed using (MeSH) terms- Gingival Crevicular fluid and Cytokines, MMP's, NE, PGE-2, A2M, B2M, ALP, AST, Osteocalcin and Calprotectin. Articles published between year 2000-2016 were reviewed and were included based on inclusion and exclusion criteria. Based on this systematic review of literature, it can be concluded that analysis of constituents of GCF can be used as an effective and efficient diagnostic tool of periodontal diseases. These biomarkers in turn with their prognostic significance could act as a valuable tool in the combat of periodontal disease. Publication Type Journal Article. Year of Publication 2018 <84> Unique Identifier 29106513 Title Effect of orthodontic treatment on periodontal clinical attachment: a systematic review and meta-analysis. Source European Journal of Orthodontics. 40(2):176-194, 2018 Apr 06. VI 1 Status In-Data-Review Authors Papageorgiou SN; Papadelli AA; Eliades T. Authors Full Name Papageorgiou, Spyridon N; Papadelli, Anastasia A; Eliades, Theodore. Institution Papageorgiou, Spyridon N. Clinic of Orthodontics and Pediatric Dentistry, Center of Dental Medicine, University of Zurich, Zurich, Switzerland. Papadelli, Anastasia A. Department of Periodontology, School of Dentistry, National and Kapodistrian University of Athens, Athens, Greece. Eliades, Theodore. Clinic of Orthodontics and Pediatric Dentistry, Center of Dental Medicine, University of Zurich, Zurich, Switzerland. Local Messages THIS JOURNAL IS AVAILABLE IN THE BDA LIBRARY, TO REQUEST THIS ARTICLE FROM THE LIBRARY GO TO: https://www.bda.org/library/journals-articles/Documents/photocopy-request-form.pdf Abstract Background: Insertion of orthodontic fixed appliances has been known to induce a mostly transient qualitative and quantitative alteration of the intraoral microbiota. However, the extent to which treatment with fixed appliances might have a lasting adverse effect on the periodontal attachment of the teeth has not yet been investigated in an evidence-based manner. Objectives: Aim of this systematic review was to assess the effect of comprehensive treatment with fixed orthodontic appliances on clinical attachment levels of adolescent and adult periodontally healthy patients. Search methods: Seven databases were searched from inception to February 2017. Selection criteria: Prospective non-randomized longitudinal clinical studies. Data collection and analysis: After duplicate study selection, data extraction, and risk of bias assessment according to the Cochrane guidelines, Paule-Mandel random-effects meta-analyses of the clinical attachment loss and its 95 per cent confidence intervals (CIs) were calculated. Results: A total of 9 trials were identified that included 335 treated patients (at least 34 per cent male / 66 per cent female) with an average age of 22.6 years. The average pooled clinical attachment loss was 0.11 mm (9 studies; 335 patients; 95 per cent CI =

0.12 mm gain to 0.34 mm loss; P = 0.338) with high heterogeneity. Furthermore, one study hinted that a small amount of clinical attachment might be gained by intrusion of upper incisors. Additional analyses indicated that the results were robust to addition of untreated patient groups, while patient age and timing of outcome measurement might play an important role. Conclusions: According to existing evidence from longitudinal clinical studies orthodontic treatment with fixed appliances has little to no clinically relevant effect on periodontal clinical attachment levels. Registration: PROSPERO (CRD42017057042). Funding: None. Publication Type Journal Article. Year of Publication 2018 <85> Unique Identifier 29751147 Title Assessment of genotyping tools applied in genetic susceptibility studies of periodontal disease: A systematic review. [Review] Source Archives of Oral Biology. 92:38-50, 2018 Aug. VI 1 Status In-Process Authors de Coo A; Quintela I; Blanco J; Diz P; Carracedo A. Authors Full Name de Coo, Alicia; Quintela, Ines; Blanco, Juan; Diz, Pedro; Carracedo, Angel. Institution de Coo, Alicia. Grupo de Medicina Xenomica, Universidad de Santiago de Compostela (USC), Santiago de Compostela, A Coruna, Spain. Electronic address: [email protected]. Quintela, Ines. Grupo de Medicina Xenomica, Centro Nacional de Genotipado - Plataforma de Recursos Biomoleculares y Bioinformaticos - Instituto de Salud Carlos III (CeGen-PRB2-ISCIII), Universidad de Santiago de Compostela (USC), Santiago de Compostela, A Coruna, Spain. Blanco, Juan. Grupo de Odontologia Medico-Quirurgica (OMEQUI), Instituto de Investigacion Sanitaria de Santiago de Compostela (IDIS), Universidad de Santiago de Compostela (USC), Santiago de Compostela, A Coruna, Spain. Diz, Pedro. Grupo de Odontologia Medico-Quirurgica (OMEQUI), Instituto de Investigacion Sanitaria de Santiago de Compostela (IDIS), Universidad de Santiago de Compostela (USC), Santiago de Compostela, A Coruna, Spain. Carracedo, Angel. Grupo de Medicina Xenomica, Centro Nacional de Genotipado - Plataforma de Recursos Biomoleculares y Bioinformaticos - Instituto de Salud Carlos III (CeGen-PRB2-ISCIII), Universidad de Santiago de Compostela (USC), Santiago de Compostela, A Coruna, Spain; Grupo de Medicina Xenomica, CIBERER, Fundacion Publica Galega de Medicina Xenomica - SERGAS Santiago de Compostela, A Coruna, Spain. Local Messages THIS JOURNAL IS AVAILABLE IN THE BDA LIBRARY UP TO 2014, TO REQUEST THIS ARTICLE FROM THE LIBRARY GO TO: https://www.bda.org/library/journals-articles/Documents/photocopy-request-form.pdf Abstract OBJECTIVE: A systematic review to evaluate the various genotyping tools and study strategies employed to define genetic susceptibility to periodontitis. METHODS: The review was performed in accordance with Preferred Reporting Items for Systematic Review and Meta-Analysis guidelines. The search for publications referring to the genetic bases of periodontal disease was performed on the MEDLINE-PubMed and Cochrane Library databases, on trials registers, and on the web pages of regulatory agencies. RESULTS: We found 2439 potentially eligible articles, of which only 25 satisfied the established inclusion criteria and were processed for data extraction. The review revealed marked heterogeneity between studies, caused in part by the lack of a universally accepted definition for periodontitis phenotypes and by the variety of genotyping tools available. The most commonly used technique was genotyping candidate genes. CONCLUSION: The few rigorous studies that have been published on genetic susceptibility to periodontitis are subject to severe methodological bias due to their design and the genotyping tools employed. Despite their limitations, candidate gene studies continue to be the predominant methodological approach, rather than genome-wide association studies. Further studies must be designed using a universally accepted, validated diagnostic criterion for periodontitis, analysing multiple genes and polymorphisms in combination with rare variants. Copyright © 2018 Elsevier Ltd. All rights reserved. Publication Type Journal Article. Review. Year of Publication 2018 <86> Unique Identifier 29456771 Title

Pulpal and Periodontal Tissues Changes Associated with Le Fort I and Sagittal Split Ramus Osteotomies: A review. [Review] Source The open dentistry journal. 12:24-31, 2018. VI 1 Status PubMed-not-MEDLINE Authors Lazaridis K; Lazaridou M; Athanasiou AE. Authors Full Name Lazaridis, Konstantinos; Lazaridou, Maria; Athanasiou, Athanasios E. Institution Lazaridis, Konstantinos. Department of Orthodontics, Faculty of Dentistry, Aristotle University of Thessaloniki, Thessaloniki, Greece. Lazaridou, Maria. Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Aristotle University of Thessaloniki, Thessaloniki, Greece. Lazaridou, Maria. Department of Orthodontics, Faculty of Dentistry, Aristotle University of Thessaloniki, Thessaloniki, Greece. Athanasiou, Athanasios E. Department of Orthodontics, Hamdan Bin Mohammed College of Dental Medicine, Mohammed Bin Rashid University of Medicine and Health Sciences, Dubai, United Arab Emirates. Abstract Introduction: Le Fort I and sagittal split ramus osteotomies are the most commonly performed orthognathic surgery procedures on the maxilla and mandible, respectively. Techniques: Despite progress in the techniques, these procedures may still be associated with morbidity, expressed as inflammation, inadequate bony union, periodontal damages or in extreme cases even total bone loss. Discussion: Through a comprehensive review of the literature, the influences of maxillary and mandibular surgery on Pulpal Blood Flow (PBF), pulp sensitivity and pulp vitality are examined. Moreover, adverse effects of maxillary surgery on tooth color and periodontal tissues are also reported. The effects had a variety of expression. Concerning maxillary surgery, some studies showed an initial increase in PBF followed by a decrease to the baseline or even lower levels after 1-3 months. Other studies found an initial decrease in PBF followed by an increase soon after. There were also studies that showed no significant PBF changes, in contrast. Conclusion: Concerning mandibular surgery, a recent study showed a decrease in PBF immediately after sagittal split ramus osteotomy. Some authors detected tooth discoloration of maxillary teeth after Le Fort I osteotomy. Root resorption and root injury were also detected, but were of minor significance. Usually, these adverse effects derive from injury of the vessels of the palatal pedicle. This pedicle should be maintained intact for the avoidance of blood flow impairments. In addition, the descending palatine artery should be protected during maxillary surgery procedures in order to maintain the highest possible blood flow on the maxillary teeth. Publication Type Journal Article. Review. Year of Publication 2018 <87> Unique Identifier 29125699 Title Prevalence of diabetes mellitus in people clinically diagnosed with periodontitis: A systematic review and meta-analysis of epidemiologic studies. [Review] Source Journal of Clinical Periodontology. 45(6):650-662, 2018 Jun. VI 1 Status In-Data-Review Authors Ziukaite L; Slot DE; Van der Weijden FA. Author NameID Slot, Dagmar E; ORCID: http://orcid.org/0000-0001-7234-0037 Van der Weijden, Fridus A; ORCID: http://orcid.org/0000-0002-5075-8384 Authors Full Name Ziukaite, Laura; Slot, Dagmar E; Van der Weijden, Fridus A. Institution Ziukaite, Laura. Academic Centre for Dentistry Amsterdam (ACTA), University of Amsterdam and VU University, Amsterdam, The Netherlands. Slot, Dagmar E. Academic Centre for Dentistry Amsterdam (ACTA), University of Amsterdam and VU University, Amsterdam, The Netherlands. Van der Weijden, Fridus A. Academic Centre for Dentistry Amsterdam (ACTA), University of Amsterdam and VU University, Amsterdam, The Netherlands. Local Messages THIS JOURNAL IS AVAILABLE IN THE BDA LIBRARY, TO REQUEST THIS ARTICLE FROM THE LIBRARY GO TO: https://www.bda.org/library/journals-articles/Documents/photocopy-request-form.pdf Abstract OBJECTIVES: Diabetes mellitus and periodontitis are complex chronic diseases with an established bidirectional relationship. This systematic review evaluated in subjects with professionally diagnosed periodontitis the prevalence and odds of having diabetes.

METHODS: The MEDLINE-PubMed, CENTRAL and EMBASE databases were searched. Prevalence of diabetes mellitus among subjects with periodontitis was extracted or if possible calculated. RESULTS: From the 803 titles and abstracts that came out of the search, 27 papers met the initial criteria. Prevalence of diabetes was 13.1% among subjects with periodontitis and 9.6% among subjects without periodontitis. Based on subanalysis, for subjects with periodontitis, the prevalence of diabetes was 6.2% when diabetes was self-reported, compared to 17.3% when diabetes was clinically assessed. The highest prevalence of diabetes among subjects with periodontitis was observed in studies originating from Asian countries (17.2%, n = 18,002) and the lowest in studies describing populations from Europe (4.3%, n = 7,858). The overall odds ratio for patients with diabetes to be among subjects with periodontitis as compared to those without periodontitis was 2.27 (95% CI [1.90;2.72]). A substantial variability in the definitions of periodontitis, combination of self-reported and clinically assessed diabetes, lack of confounding for diabetes control in included studies introduces estimation bias. CONCLUSIONS: The overall prevalence and odds of having diabetes are higher within periodontitis populations compared to people without periodontitis. Self-reported diabetes underestimates the prevalence when compared to this condition assessed clinically. Geographical differences were observed: the highest diabetes prevalence among subjects with periodontitis was observed in studies conducted in Asia and the lowest in studies originating from Europe. Copyright © 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. Publication Type Journal Article. Review. Year of Publication 2018 <88> Unique Identifier 29471149 Title Is adjunctive photodynamic therapy more effective than scaling and root planing alone in the treatment of periodontal disease in hyperglycemic patients? A systematic review. [Review] Source Photodiagnosis & Photodynamic Therapy. 22:1-6, 2018 Jun. VI 1 Status In-Process Authors Javed F; Salehpoor D; Al-Dhafeeri T; Yousuf M; Malmstrom H; Khan J; Akram Z. Authors Full Name Javed, Fawad; Salehpoor, Danial; Al-Dhafeeri, Talal; Yousuf, Muhammad; Malmstrom, Hans; Khan, Junad; Akram, Zohaib. Institution Javed, Fawad. Department of General Dentistry, Eastman Institute for Oral Health, University of Rochester, NY, 14620, USA. Salehpoor, Danial. Department of General Dentistry, Eastman Institute for Oral Health, University of Rochester, NY, 14620, USA. Al-Dhafeeri, Talal. Department of General Dentistry, Eastman Institute for Oral Health, University of Rochester, NY, 14620, USA. Yousuf, Muhammad. Department of Advanced Comprehensive Dentistry, College of Dentistry, New York University, NY, USA. Malmstrom, Hans. Department of General Dentistry, Eastman Institute for Oral Health, University of Rochester, NY, 14620, USA. Khan, Junad. Department of Orthodontics and Orofacial Pain, Eastman Institute for Oral Health, University of Rochester, NY 14620, USA. Akram, Zohaib. Department of Periodontology, Faculty of Dentistry, Ziauddin University, Karachi, Pakistan. Electronic address: [email protected]. Abstract BACKGROUND: To assess the impact of scaling and root planing (SRP) with and without adjunct photodynamic therapy (PDT) in the treatment of periodontal disease (PD) in hyperglycemic patients. METHODS: Databases (MEDLINE, EMBASE; and CENTRAL) were searched up to December 2017. The addressed PICO question was: "What is the effectiveness of adjunctive PDT to non-surgical periodontal treatment by means of clinical periodontal and glycemic parameters in hyperglycemic patients?" RESULTS: Four clinical trials and 1 experimental study were included. Energy fluence, power output, power density and duration of irradiation were 2.79J per square centimeters (Jcm-2), 150 milliwatts (mW), 428 milliwatts per square centimeters (mW/cm2) and 133s (s) respectively. All studies reporting clinical periodontal and metabolic parameters, showed that aPDT was effective in the treatment of periodontal inflammation in hyperglycemic patients at follow-up. When compared with SRP alone, none of the studies showed additional benefits of PDT as compared to SRP alone at follow up. Three studies showed no influence of SRP with or without aPDT on HbA1c levels. One study showed a significant reduction of HbA1c levels in adjunctive aPDT as compared to SRP alone at follow-up. CONCLUSION: It remains debatable whether adjunctive PDT as compared to SRP is effective in the treatment of periodontal inflammation and reduction of HbA1c levels in hyperglycemic patients. Copyright © 2018 Elsevier B.V. All rights reserved. Publication Type Journal Article. Review. Year of Publication 2018

<89> Unique Identifier 29656920 Title Effect of Smoking on Periodontitis: A Systematic Review and Meta-regression. [Review] Source American Journal of Preventive Medicine. 54(6):831-841, 2018 Jun. VI 1 Status In-Data-Review Authors Leite FRM; Nascimento GG; Scheutz F; Lopez R. Authors Full Name Leite, Fabio R M; Nascimento, Gustavo G; Scheutz, Flemming; Lopez, Rodrigo. Institution Leite, Fabio R M. Section of Periodontology, Department of Dentistry and Oral Health, Aarhus University, Aarhus, Denmark. Electronic address: [email protected]. Nascimento, Gustavo G. Section of Periodontology, Department of Dentistry and Oral Health, Aarhus University, Aarhus, Denmark. Scheutz, Flemming. Section of Periodontology, Department of Dentistry and Oral Health, Aarhus University, Aarhus, Denmark. Lopez, Rodrigo. Section of Periodontology, Department of Dentistry and Oral Health, Aarhus University, Aarhus, Denmark. Abstract CONTEXT: The study systematically reviewed articles on the association between tobacco smoking and periodontitis, as it has been hypothesized that smoking affects the course of periodontitis through impairment of immunological and vascular mechanisms. EVIDENCE ACQUISITION: Searches of articles indexed in PubMed, Scopus, and Embase were performed up to and including May 2017. Search strategy included MeSH and free terms: periodontitis, periodontal diseases, smoking, tobacco use, tobacco, tobacco products, cigarette, pipe, and cigar. Only original prospective longitudinal studies that investigated the association between smoking and periodontitis incidence or progression were included. Results were shown as combined risk ratio. Meta-regression and subgroup analyses were used to explore potential sources of heterogeneity. Analyses were conducted in August 2017. EVIDENCE SYNTHESIS: Twenty-eight studies were included in the review; of these, only 14 presented data that could be included in the meta-analysis. Pooled adjusted risk ratios estimate that smoking increases the risk of periodontitis by 85% (risk ratio=1.85, 95% CI=1.5, 2.2). Meta-regression demonstrated that age explained 54.2% of the variability between studies, time of follow-up explained 13.5%, loss to follow-up 10.7%, criteria used to assess the periodontal status explained 2.1%, and severity of periodontitis explained 16.9%. CONCLUSIONS: Smoking has a detrimental effect on the incidence and progression of periodontitis. Tobacco smoking, therefore, is important information that should be assessed along with other risk factors for periodontitis. Copyright © 2018 American Journal of Preventive Medicine. Published by Elsevier Inc. All rights reserved. Publication Type Journal Article. Review. Year of Publication 2018 <90> Unique Identifier 29755526 Title Salivary Levels of Hemoglobin for Screening Periodontal Disease: A Systematic Review. [Review] Source International Journal of Dentistry. 2018:2541204, 2018. VI 1 Status PubMed-not-MEDLINE Authors Nomura Y; Okada A; Tamaki Y; Miura H. Author NameID Nomura, Yoshiaki; ORCID: https://orcid.org/0000-0002-0814-0572 Miura, Hiroko; ORCID: https://orcid.org/0000-0003-0897-0768 Authors Full Name Nomura, Yoshiaki; Okada, Ayako; Tamaki, Yoh; Miura, Hiroko. Institution Nomura, Yoshiaki. Department of Translational Research, School of Dental Medicine, Tsurumi University, 2-1-3 Tsurumi, Tsurumi-ku, Yokohama 230-8501, Japan. Okada, Ayako. Department of Translational Research, School of Dental Medicine, Tsurumi University, 2-1-3 Tsurumi, Tsurumi-ku, Yokohama 230-8501, Japan. Tamaki, Yoh. Department of Health and Welfare Services, National Institute of Public Health, 2-3-6 Minami, Wako-shi, Saitama 351-0197, Japan. Miura, Hiroko. Department of International Health and Collaboration, National Institute of Public Health, 2-3-6 Minami, Wako-shi, Saitama 351-0197, Japan. Abstract

Periodontal disease is a common inflammatory disease. It affects about 20-50% of global population in both developed and developing countries. Early detection of slight changes of periodontal tissue plays an important role in prevention of onset and progression of periodontal disease. Hence, there is a need of a screening test to assess periodontal tissue for health check-ups. Salivary levels hemoglobin (Hb) has been proposed to assess the conditions of the inflammation of gingiva. The aim of this systematic review was to evaluate and summarize critically the current evidences for Hb as periodontal screening test. We performed a literature search of report published using PubMed databases. A total of 55 articles were retrieved and 16 were selected. Our review focuses on corelation coefficient with periodontal clinical parameters or sensitivity and specificity. As a result, fourteen studies calculated sensitivity and specificity of Hb. Six studies measured salivary levels hemoglobin at laboratory: three studies used polyclonal antibody reactions and other studies used colorimetric tests. Eight studies used paper strip method: 4 studies used monoclonal antibody reaction and 4 studies used colorimetric tests. Youden's indexes by antibody reaction were better than those of colorimetric methods. Evidences are described above and further studies are necessary to set the cut off values stratified by gender, age and number of remaining teeth. Publication Type Journal Article. Review. Year of Publication 2018 <91> Unique Identifier 29700503 Title The efficacy of air polishing devices in supportive periodontal therapy: A systematic review and meta-analysis. Source Quintessence International. 49(6):453-467, 2018. VI 1 Status In-Process Authors Ng E; Byun R; Spahr A; Divnic-Resnik T. Authors Full Name Ng, Ethan; Byun, Roy; Spahr, Axel; Divnic-Resnik, Tihana. Local Messages THIS JOURNAL IS AVAILABLE IN THE BDA LIBRARY, TO REQUEST THIS ARTICLE FROM THE LIBRARY GO TO: https://www.bda.org/library/journals-articles/Documents/photocopy-request-form.pdf Abstract OBJECTIVE: This systematic review analyzes existing literature on the clinical efficacy of air polishing devices (APDs), discussing the evidence-based data available for justifying their use as an alternative to conventional periodontal debridement in supportive periodontal therapy. The main objective of the review was to assess whether APD was as equally efficient or superior in obtaining successful treatment outcomes when compared with conventional methods. DATA SOURCES: Following PRISMA guidelines, a systematic literature search of articles in English, up to December 2016, was conducted using PubMed, Cochrane, and Medline. Relevant articles were selected based on specific criteria. Seven studies were selected for the final assessment. One more study was added after a manual search of the literature. Due to considerable heterogeneity in study designs and outcome variables measured, only clinical parameters (probing depth, bleeding on probing, and clinical attachment level) were selected for meta-analysis. CONCLUSION: The studies selected for this systematic review provide some evidence that APDs as monotherapy could be an alternative to conventional debridement of single- and multi-rooted teeth with no furcation involvement, during supportive periodontal therapy. Comparing clinical and microbiologic outcomes, APDs seem to be as effective as conventional treatments. The primary advantage for the use of APDs in supportive periodontal therapy seems to be their ability to efficiently remove biofilm, without causing damage to the periodontal soft tissues or tooth and root structure. There may also be an advantage regarding patient comfort and time consumed. Publication Type Journal Article. Year of Publication 2018 <92> Unique Identifier 29492977 Title Vitamin D levels and risk for periodontal disease: A systematic review. [Review] Source Journal of Periodontal Research. 53(3):298-305, 2018 Jun. VI 1 Status In-Process Authors Pinto JPNS; Goergen J; Muniz FWMG; Haas AN. Author NameID Haas, A N; ORCID: http://orcid.org/0000-0003-0531-6234 Authors Full Name Pinto, J P N S; Goergen, J; Muniz, F W M G; Haas, A N. Institution Pinto, J P N S. Periodontology, Faculty of Dentistry, Federal University of Rio Grande do Sul, Porto Alegre, Brazil.

Goergen, J. Periodontology, Faculty of Dentistry, Federal University of Rio Grande do Sul, Porto Alegre, Brazil. Muniz, F W M G. Periodontology, Faculty of Dentistry, Federal University of Rio Grande do Sul, Porto Alegre, Brazil. Haas, A N. Periodontology, Faculty of Dentistry, Federal University of Rio Grande do Sul, Porto Alegre, Brazil. Local Messages THIS JOURNAL IS AVAILABLE IN THE BDA LIBRARY, TO REQUEST THIS ARTICLE FROM THE LIBRARY GO TO: https://www.bda.org/library/journals-articles/Documents/photocopy-request-form.pdf Abstract OBJECTIVE: To evaluate the existing evidence supporting or refuting the following questions: (i) Do patients with lower vitamin D levels have higher risk for periodontal disease? (ii) Are periodontal treatment outcomes improved by the adjuvant supplementation of vitamin D or by elevated serum vitamin D levels? MATERIAL AND METHODS: MEDLINE, SCOPUS, EMBASE and Cochrane Central Register of Controlled Trials (CENTRAL) databases were searched up to September 2017. Studies were included if they had measured serum vitamin D levels or vitamin D intake and any periodontal parameter. RESULTS: Overall, 27 studies were included (13 cross-sectional studies, 6 case-control studies, 5 cohort studies, 2 randomized clinical trials and 1 case series study). Sixty-five percent of the cross-sectional studies reported significant associations between low vitamin D levels and poor periodontal parameters. None of the observational longitudinal studies found that periodontal disease progression could be attributed to lower vitamin D levels. No interventional studies that evaluated the use of vitamin D supplementation as a solely adjuvant to periodontal treatment was found. No meta-analysis was performed due to high variability across studies. CONCLUSION: The data to support or refute the association between vitamin D levels and periodontal disease are inconclusive at the moment. More rigorously designed longitudinal studies with standardized definitions of periodontal disease and vitamin D are necessary. Copyright © 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. Publication Type Journal Article. Review. Year of Publication 2018 <93> Unique Identifier 29352465 Title Efficacy of local phytotherapy in the nonsurgical treatment of periodontal disease: A systematic review. [Review] Source Journal of Periodontal Research. 53(3):288-297, 2018 Jun. VI 1 Status In-Process Authors Moro MG; Silveira Souto ML; Franco GCN; Holzhausen M; Pannuti CM. Author NameID Moro, M G; ORCID: http://orcid.org/0000-0001-7601-8168 Authors Full Name Moro, M G; Silveira Souto, M L; Franco, G C N; Holzhausen, M; Pannuti, C M. Institution Moro, M G. Department of Stomatology, Division of Periodontics, School of Dentistry, University of Sao Paulo (FO-USP), Sao Paulo, Brazil. Silveira Souto, M L. Department of Stomatology, Division of Periodontics, School of Dentistry, University of Sao Paulo (FO-USP), Sao Paulo, Brazil. Franco, G C N. Department of General Biology, University of Ponta Grossa (UEPG), Parana, Brazil. Holzhausen, M. Department of Stomatology, Division of Periodontics, School of Dentistry, University of Sao Paulo (FO-USP), Sao Paulo, Brazil. Pannuti, C M. Department of Stomatology, Division of Periodontics, School of Dentistry, University of Sao Paulo (FO-USP), Sao Paulo, Brazil. Local Messages THIS JOURNAL IS AVAILABLE IN THE BDA LIBRARY, TO REQUEST THIS ARTICLE FROM THE LIBRARY GO TO: https://www.bda.org/library/journals-articles/Documents/photocopy-request-form.pdf Abstract Herbal drugs are commonly used in the treatment of several diseases, including periodontitis. So far, no systematic review had evaluated the evidence regarding the efficacy of these agents in the treatment of periodontal disease. Therefore, the purpose of this review was to evaluate the effect of local application of phytotherapic agents as adjuncts to scaling and root planing (SRP), compared to SRP alone, on clinical parameters of chronic periodontal patients. Only randomized controlled trials of at least 3 months follow-up, of SRP alone in association with local phytotherapic agents were included. MEDLINE (PubMed), Google Scholar and LILACS databases were searched for articles published up to October 2016. Random-effects meta-analyses were conducted for clinical attachment level and probing pocket depth (PPD) change after treatment. Of 1861 papers potentially relevant, 7 were included. All studies showed that periodontal treatment in association with local phytotherapic delivery promotes a significant PPD reduction and the majority of them showed clinical attachment level gain. The local use of phytotherapy as an adjunct to SRP may promote additional benefits in PPD reduction and clinical attachment level gain. However, these results must be interpreted with caution due to the small sample size, high risk of bias and heterogeneity of the studies. Copyright © 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Publication Type Journal Article. Review. Year of Publication 2018 <94> Unique Identifier 29211309 Title Statins in nonsurgical and surgical periodontal therapy. A systematic review and meta-analysis of preclinical in vivo trials. [Review] Source Journal of Periodontal Research. 53(3):267-287, 2018 Jun. VI 1 Status In-Process Authors Bertl K; Steiner I; Pandis N; Buhlin K; Klinge B; Stavropoulos A. Author NameID Bertl, K; ORCID: http://orcid.org/0000-0002-8279-7943 Stavropoulos, A; ORCID: http://orcid.org/0000-0001-8161-3754 Authors Full Name Bertl, K; Steiner, I; Pandis, N; Buhlin, K; Klinge, B; Stavropoulos, A. Institution Bertl, K. Department of Periodontology, Faculty of Odontology, University of Malmo, Malmo, Sweden. Bertl, K. Division of Oral Surgery, School of Dentistry, Medical University of Vienna, Vienna, Austria. Steiner, I. Private Practice, Taiskirchen, Austria. Steiner, I. Postgraduate Course Periodontology, Medical University of Vienna, Vienna, Austria. Pandis, N. Department of Orthodontics and Dentofacial Orthopedics, Dental School/Medical Faculty, University of Bern, Bern, Switzerland. Buhlin, K. Division of Periodontology, Department of Dental Medicine, Karolinska Institute, Huddinge, Sweden. Klinge, B. Department of Periodontology, Faculty of Odontology, University of Malmo, Malmo, Sweden. Stavropoulos, A. Department of Periodontology, Faculty of Odontology, University of Malmo, Malmo, Sweden. Local Messages THIS JOURNAL IS AVAILABLE IN THE BDA LIBRARY, TO REQUEST THIS ARTICLE FROM THE LIBRARY GO TO: https://www.bda.org/library/journals-articles/Documents/photocopy-request-form.pdf Abstract The cholesterol-lowering drugs, statins, possess anti-inflammatory, antimicrobial and pro-osteogenic properties, and thus have been tested as an adjunct to periodontal treatment. The present systematic review aimed to answer the following focused research question: What is the effect of local and/or systemic statin use on periodontal tissues in preclinical in vivo studies of experimentally induced periodontitis (EIP) and/or acute/chronified periodontal defect (ACP) models? A literature search (of Medline/PubMed, Embase/Ovid, CENTRAL/Ovid) using the following main eligibility criteria was performed: (i) English or German language; (ii) controlled preclinical in vivo trials; (iii) local and/or systemic statin use in EIP and/or ACP models; and (iv) quantitative evaluation of periodontal tissues (i.e., alveolar bone level/amount, attachment level, cementum formation, periodontal ligament formation). Sixteen studies in EIP models and 7 studies in ACP models evaluated simvastatin, atorvastatin or rosuvastatin. Thirteen of the EIP (81%) and 2 of the ACP (29%) studies presented significantly better results in terms of alveolar bone level/amount in favor of statins. Meta-analysis based on 14 EIP trials confirmed a significant benefit of local and systemic statin use (P < .001) in terms of alveolar bone level/amount; meta-regression revealed that statin type exhibited a significant effect (P = .014) in favor of atorvastatin. Three studies reported a significantly higher periodontal attachment level in favor of statin use (P < .001). Complete periodontal regeneration was never observed; furthermore, statins did not exert any apparent effect on cementum formation. Neither local nor systemic use of statins resulted in severe adverse effects. Statin use in periodontal indications has a positive effect on periodontal tissue parameters, supporting the positive results already observed in clinical trials. Nevertheless, not all statins available have been tested so far, and further research is needed to identify the maximum effective concentration/dose and optimal carrier. Copyright © 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. Publication Type Journal Article. Review. Year of Publication 2018 <95> Unique Identifier 29119729 Title Efficacy of statin delivery as an adjunct to scaling and root planing in the treatment of chronic periodontitis: A meta-analysis. [Review] Source Journal of Investigative & Clinical Dentistry. 9(2):e12304, 2018 May. VI 1 Status In-Process Authors Akram Z; Vohra F; Javed F. Author NameID

Akram, Zohaib; ORCID: http://orcid.org/0000-0001-9618-8818 Authors Full Name Akram, Zohaib; Vohra, Fahim; Javed, Fawad. Institution Akram, Zohaib. Department of Periodontology, Faculty of Dentistry, Ziauddin University, Karachi, Pakistan. Vohra, Fahim. Department of Prosthetic Dental Sciences, College of Dentistry, King Saud University, Riyadh, Saudi Arabia. Javed, Fawad. Department of General Dentistry, Eastman Institute for Oral Health, University of Rochester, Rochester, New York, USA. Abstract The action of statins in stimulating bone formation and having other pleiotropic effects, such as anti-inflammatory and immunomodulatory effects, has justified their use as an adjunct to scaling and root planing (SRP) in the treatment of chronic periodontitis (CP). The aim of the present study was to evaluate the efficacy of statin delivery as an adjunct to SRP in the treatment of CP. Electronic searches were conducted using the following databases: MEDLINE, EMBASE, Cochrane Central Register of Controlled Trials, and Cochrane Oral Health Group Trials Register, up until July 2017. The primary outcome was probing depth (PD), while the secondary outcomes were changes in clinical attachment level (CAL) and bone defect (BD) fill. Eleven studies were included, and all showed significant PD reduction, CAL gain, and BD fill with adjunctive statin delivery compared to SRP alone. The meta-analysis showed significant improvement in periodontal parameters for atorvastatin (PD: weighted mean difference [WMD] = -1.84, -2.56 to -1.12, P < .001; CAL: WMD = -2.31, -3.58 to -1.03, P < .001; BD fill: WMD = 2.66, -3.92 to -1.39, P < .001), simvastatin (PD: WMD = -1.91, -2.27 to -1.55, P < .001; CAL: WMD = -1.91, -2.27 to -1.55, P = .001; BD: WMD = -1.52, -2.20 to -0.85, P < .001), and rosuvastatin (PD: WMD = -0.94, -1.32 to -0.55, P < .001; CAL: WMD = -1.00, -1.41 to -0.60, P < .001; BD fill: WMD = -1.30, -1.80 to -0.79, P < .001). Adjunctive statin delivery appears to be effective in reducing PD, CAL gain, and BD fill in CP, and therefore, these drugs could be a promising therapeutic option for periodontal regeneration in future. Copyright © 2017 John Wiley & Sons Australia, Ltd. Publication Type Journal Article. Review. Year of Publication 2018 <96> Unique Identifier 29349893 Title Is overweight/obesity a risk factor for periodontitis in young adults and adolescents?: a systematic review. [Review] Source Obesity Reviews. 19(6):852-883, 2018 Jun. VI 1 Status In-Data-Review Authors Khan S; Barrington G; Bettiol S; Barnett T; Crocombe L. Author NameID Khan, S; ORCID: http://orcid.org/0000-0002-6695-4013 Authors Full Name Khan, S; Barrington, G; Bettiol, S; Barnett, T; Crocombe, L. Institution Khan, S. Centre for Rural Health, University of Tasmania, Hobart, Tas., Australia. Khan, S. Charles Perkins Centre, University of Sydney, Camperdown, NSW, Australia. Barrington, G. School of Medicine, University of Tasmania, Hobart, Tas., Australia. Bettiol, S. School of Medicine, University of Tasmania, Hobart, Tas., Australia. Barnett, T. Centre for Rural Health, University of Tasmania, Hobart, Tas., Australia. Crocombe, L. Centre for Rural Health, University of Tasmania, Hobart, Tas., Australia. Abstract BACKGROUND: Obesity in young adults and adolescents is associated with chronic co-morbidities. This project investigated whether being overweight or obese is a risk factor for periodontitis in adolescents (13-17 years) and young adults (18-34 years). METHODS: A search of 12 databases was conducted using Medical Subject Headings/Index and Emtree terms. Based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses, articles published between 2003 and 2016 were screened that reported periodontal and anthropometric measures. The Newcastle-Ottawa Scale was used to appraise the quality of studies. RESULTS: Of 25 eligible studies from 12 countries, 17 showed an association between obesity and periodontitis (odds ratios ranged from 1.1 to 4.5). The obesity indicators of body mass index, waist circumference, waist-hip ratio and body fat percentage were significantly associated with measures of periodontitis of bleeding on probing, plaque index, probing depths, clinical attachment loss, calculus, oral hygiene index and community periodontal index. Two prospective cohort studies in the review showed no significant association between obesity and periodontitis, but these studies had limitations of study design and used inappropriate epidemiological diagnostic measures of periodontitis. CONCLUSION: There was evidence to suggest that obesity is associated with periodontitis in adolescents and young adults. Systematic Review Registration: PROSPERO Registration Number: CRD42016046507. Copyright © 2018 World Obesity Federation. Publication Type Journal Article. Review. Year of Publication

2018 <97> Unique Identifier 28871892 Title Association between asthma and periodontal disease: A systematic review and meta-analysis. [Review] Source Journal of Periodontology. 89(4):440-455, 2018 Apr. VI 1 Status In-Data-Review Authors Moraschini V; Calasans-Maia JA; Calasans-Maia MD. Authors Full Name Moraschini, Vittorio; Calasans-Maia, Jose de Albuquerque; Calasans-Maia, Monica Diuana. Institution Moraschini, Vittorio. Department of Periodontology, School of Dentistry, Fluminense Federal University, Niteroi, Rio de Janeiro, Brazil. Calasans-Maia, Jose de Albuquerque. Department of Orthodontics, School of Dentistry, Fluminense Federal University. Calasans-Maia, Monica Diuana. Department of Oral Surgery, School of Dentistry, Fluminense Federal University. Local Messages THIS JOURNAL IS AVAILABLE IN THE BDA LIBRARY, TO REQUEST THIS ARTICLE FROM THE LIBRARY GO TO: https://www.bda.org/library/journals-articles/Documents/photocopy-request-form.pdf Abstract BACKGROUND: The aim of this systematic review (SR) is to evaluate the association between asthma and periodontal disease. METHODS: An electronic search without date or language restrictions was carried out in PubMed/MEDLINE, Cochrane Central Register of Controlled Trials, Web of Science, and LILACS until May 2016. In addition, manual searches and searches of the gray literature were conducted. The search process, data analysis, and quality assessment were performed by two independent reviewing authors. Eligibility criteria included prospective and retrospective cohort studies, case-controls, and randomized clinical trials. RESULTS: The search and selection process yielded 21 studies, published between 1979 and 2017. The meta-analysis showed a statistically significant difference for the parameters of gingival bleeding, plaque index, and gingival index for participants with asthma (P < 0.001). CONCLUSION: Data from this SR strongly suggest the association of asthma with periodontal disease. Copyright © 2017 American Academy of Periodontology. Publication Type Journal Article. Review. Year of Publication 2018 <98> Unique Identifier 29595347 Title Relationship between human immunodeficiency virus (HIV-1) infection and chronic periodontitis. Source Expert Review of Clinical Immunology. 14(4):315-327, 2018 Apr. VI 1 Status In-Data-Review Authors Polvora TLS; Nobre AVV; Tirapelli C; Taba M Jr; Macedo LD; Santana RC; Pozzetto B; Lourenco AG; Motta ACF. Author NameID Taba, Mario Jr; ORCID: http://orcid.org/0000-0002-7098-5090 Motta, Ana Carolina F; ORCID: http://orcid.org/0000-0002-3887-9239 Authors Full Name Polvora, Tabata Larissa S; Nobre, Atila Vinicius V; Tirapelli, Camila; Taba, Mario Jr; Macedo, Leandro Dorigan de; Santana, Rodrigo Carvalho; Pozzetto, Bruno; Lourenco, Alan Grupioni; Motta, Ana Carolina F. Institution Polvora, Tabata Larissa S. a Department of Stomatology, School of Dentistry , University of Sao Paulo , Sao Paulo , Brazil. Nobre, Atila Vinicius V. b Department of Oral & Maxillofacial Surgery, and Periodontology, School of Dentistry of Ribeirao Preto , University of Sao Paulo , Ribeirao Preto , Brazil. Tirapelli, Camila. c Department of Dental Material and Prosthesis, School of Dentistry of Ribeirao Preto , USP - University of Sao Paulo , Ribeirao Preto , Brazil. Taba, Mario Jr. b Department of Oral & Maxillofacial Surgery, and Periodontology, School of Dentistry of Ribeirao Preto , University of Sao Paulo , Ribeirao Preto , Brazil. Macedo, Leandro Dorigan de. d Division of Dentistry and Stomatology, Clinical Hospital, Ribeirao Preto Medical School , University of Sao Paulo , Ribeirao Preto , Brazil. Santana, Rodrigo Carvalho. e Department of Internal Medicine, Ribeirao Preto Medical School , USP - University of Sao Paulo , Ribeirao Preto , Brazil.

Pozzetto, Bruno. f GIMAP EA 3064 (Groupe Immunite des Muqueuses et Agents Pathogenes) , University of Lyon , Saint-Etienne , France. Lourenco, Alan Grupioni. g Department of Stomatology, Public Oral Health and Forensic Dentistry, School of Dentistry of Ribeirao Preto , University of Sao Paulo , Ribeirao Preto , Brazil. Motta, Ana Carolina F. g Department of Stomatology, Public Oral Health and Forensic Dentistry, School of Dentistry of Ribeirao Preto , University of Sao Paulo , Ribeirao Preto , Brazil. Abstract INTRODUCTION: Current studies show that, even in the era of antiretroviral therapies, HIV-1 infection is associated with more severe and frequent refractory chronic periodontitis. Areas covered: This review, based on a systematic analysis of the literature, intends to provide an update on factors that may be involved in the pathogenesis of periodontal disease in HIV-1-infected patients, including local immunosuppression, oral microbial factors, systemic inflammation, salivary markers, and the role of gingival tissue as a possible reservoir of HIV-1. Expert commentary: The therapeutic revolution of ART made HIV-1 infection a chronic controllable disease, reduced HIV-1 mortality rate, restored at least partially the immune response and dramatically increased life expectancy of HIV-1-infected patients. Despite all these positive aspects, chronic periodontitis assumes an important role in the HIV-1 infection status for activating systemic inflammation favoring viral replication and influencing HIV-1 status, and also acting as a possible reservoir of HIV-1. All these issues still need to be clarified and validated, but have important clinical implications that certainly will benefit the diagnosis and management of chronic periodontitis in HIV-1-infected patients, and also contributes to HIV-1 eradication. Publication Type Journal Article. Year of Publication 2018 <99> Unique Identifier 29518672 Title Periodontal disease severity in subjects with dementia: A systematic review and meta-analysis. [Review] Source Archives of Gerontology & Geriatrics. 76:147-159, 2018 May - Jun. VI 1 Status In-Data-Review Authors Gusman DJR; Mello-Neto JM; Alves BES; Matheus HR; Ervolino E; Theodoro LH; de Almeida JM. Authors Full Name Gusman, David Jonathan R; Mello-Neto, Joao M; Alves, Breno Edson S; Matheus, Henrique R; Ervolino, Edilson; Theodoro, Leticia H; de Almeida, Juliano M. Institution Gusman, David Jonathan R. Department of Surgery and Integrated Clinic, Division of Periodontics, Sao Paulo State University (Unesp), School of Dentistry, Aracatuba, Sao Paulo, Brazil. Mello-Neto, Joao M. Department of Surgery and Integrated Clinic, Division of Periodontics, Sao Paulo State University (Unesp), School of Dentistry, Aracatuba, Sao Paulo, Brazil. Alves, Breno Edson S. Department of Surgery and Integrated Clinic, Division of Periodontics, Sao Paulo State University (Unesp), School of Dentistry, Aracatuba, Sao Paulo, Brazil. Matheus, Henrique R. Department of Surgery and Integrated Clinic, Division of Periodontics, Sao Paulo State University (Unesp), School of Dentistry, Aracatuba, Sao Paulo, Brazil. Ervolino, Edilson. Department of Basic Sciences, Sao Paulo State University (Unesp), School of Dentistry, Aracatuba, Sao Paulo, Brazil. Electronic address: [email protected]. Theodoro, Leticia H. Department of Surgery and Integrated Clinic, Division of Periodontics, Sao Paulo State University (Unesp), School of Dentistry, Aracatuba, Sao Paulo, Brazil. Electronic address: [email protected]. de Almeida, Juliano M. Department of Surgery and Integrated Clinic, Division of Periodontics, Sao Paulo State University (Unesp), School of Dentistry, Aracatuba, Sao Paulo, Brazil. Electronic address: [email protected]. Abstract BACKGROUND AND OBJECTIVE: Despite clinical trials and reviews attempt to assess a possible relationship between dementia and periodontal disease, no meta-analysis has been performed and this issue remains undetermined. The aim of this study is to conduct a systematic review and meta-analysis to assess severity of periodontitis in subjects with dementia. METHODS: The search was conducted in Pubmed, Embase/MEDLINE. Two independent reviewers extracted data and assessed the risk bias (Newcastle-Ottawa scale). Meta-analyses were performed using the means of probing depth (PD) and clinical attachment loss (CAL) in patients with or without dementia. The mean difference were analyzed (P<=0.05). RESULTS: Fourteen studies were included in the systematic review. In the qualitative analysis, most studies reported higher prevalence of periodontal disease in dementia patients. The studies had low risk of bias and two meta-analyses were performed for each parameter, including or not a cross-sectional study. The meta-analyses including the cross-sectional study demonstrated significant association between dementia and periodontal disease (mean difference: PD=1.41; CAL=1.40, P<0.05), however, it wasn't confirmed when the cross-sectional study was removed (1.25mm, P<0.22) and CAL (1.20mm, P<0.22). CONCLUSION: Although the qualitative analysis have suggested worse periodontal conditions in dementia patients, due to different study types and the high heterogeneity among them, the meta-analysis does not support the association between dementia and severity of periodontal disease. Copyright © 2018 Elsevier B.V. All rights reserved. Publication Type Journal Article. Review.

Year of Publication 2018 <100> Unique Identifier 29569619 Title A systematic review and meta-analysis of epidemiologic observational evidence on the effect of periodontitis on diabetes. An update of the EFP-AAP review. Source British Dental Journal. 224(6):427, 2018 Mar 23. VI 1 Status In-Data-Review Authors Anonymous. Local Messages THIS JOURNAL IS AVAILABLE IN THE BDA LIBRARY, TO REQUEST THIS ARTICLE FROM THE LIBRARY GO TO: https://www.bda.org/library/journals-articles/Documents/photocopy-request-form.pdf Abstract Periodontitis affects glycaemic control in health and diabetes. Publication Type Journal Article. Year of Publication 2018 <101> Unique Identifier 29478679 Title Gaps in Knowledge About the Association Between Maternal Periodontitis and Adverse Obstetric Outcomes: An Umbrella Review. Source The Journal of Evidencebased Dental Practice. 18(1):1-27, 2018 Mar. VI 1 Status In-Data-Review Authors Vivares-Builes AM; Rangel-Rincon LJ; Botero JE; Agudelo-Suarez AA. Authors Full Name Vivares-Builes, Annie M; Rangel-Rincon, Leidy Johana; Botero, Javier Enrique; Agudelo-Suarez, Andres A. Institution Vivares-Builes, Annie M. Faculty of Dentistry, Universidad de Antioquia, Medellin, Colombia. Rangel-Rincon, Leidy Johana. Faculty of Dentistry, Universidad de Antioquia, Medellin, Colombia. Botero, Javier Enrique. Faculty of Dentistry, Universidad de Antioquia, Medellin, Colombia. Agudelo-Suarez, Andres A. Faculty of Dentistry, Universidad de Antioquia, Medellin, Colombia. Electronic address: [email protected]. Abstract OBJECTIVES: Scientific literature has established that the periodontal condition during pregnancy could be associated with obstetric/neonatal morbidity, and these effects have an important relationship with problems during childhood and cardiovascular disease in adulthood. This umbrella review aimed to summarize the results about the association between maternal periodontitis and obstetric complications (low birth weight, preterm delivery, and preeclampsia) and identify the gaps in the scientific literature. METHODS: An umbrella review of systematic reviews with or without meta-analysis was performed. Quality evaluation and descriptive analysis of the characteristics of the included studies were conducted. RESULTS: Nineteen systematic reviews/meta-analyses were considered. In total, the systematic reviews included 99 observational studies. Most of the reviews established an association between maternal periodontitis and a higher risk of low birth weight, preterm delivery, and preeclampsia. The magnitude and statistical significance of this relationship are influenced by the context in which the studies have been conducted. Gaps were identified in the definition/evaluation of periodontal disease, criteria of gestational age for study purposes, and potential confounders, among others. CONCLUSIONS: Although scientific literature has established an association among the analyzed pathologies, conceptual and methodological gaps were identified, and they should be considered as integral components when this association is investigated. Copyright © 2017 Elsevier Inc. All rights reserved. Publication Type Journal Article. Year of Publication 2018 <102> Unique Identifier 29306532 Title

Association between Apical Periodontitis and Interleukin Gene Polymorphisms: A Systematic Review and Meta-analysis. [Review] Source Journal of Endodontics. 44(3):355-362, 2018 Mar. VI 1 Status In-Process Authors Salles AG; Antunes LAA; Kuchler EC; Antunes LS. Authors Full Name Salles, Alessandro G; Antunes, Livia A A; Kuchler, Erika Calvano; Antunes, Leonardo S. Institution Salles, Alessandro G. Postgraduate Program, School of Dentistry, Fluminense Federal University, Niteroi, Rio de Janeiro, Brazil. Antunes, Livia A A. Department of Specific Formation, School of Dentistry, Fluminense Federal University, Nova Friburgo, Rio de Janeiro, Brazil. Kuchler, Erika Calvano. Department of Pediatric Dentistry, School of Dentistry of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, Sao Paulo, Brazil. Antunes, Leonardo S. Department of Specific Formation, School of Dentistry, Fluminense Federal University, Nova Friburgo, Rio de Janeiro, Brazil. Electronic address: [email protected]. Local Messages THIS JOURNAL IS AVAILABLE IN THE BDA LIBRARY, BDA MEMBERS CAN ALSO ACCESS THIS JOURNAL ONLINE FROM 2011 TO DATE. Go to www.bda.org/ejournals Abstract INTRODUCTION: Genetic polymorphisms may result in altered gene expression or functional changes of the encoded molecules and could possibly generate a deficient immunity. Consequently, individuals with specific genotypes could be more susceptible to disease or could present an increase in disease severity. Our study is aimed to verify, through a systematic review and meta-analysis registered in the PROSPERO database (CRD42016043905), whether currently available evidence supports a relationship between interleukin gene polymorphisms and apical periodontitis (AP). METHODS: A broad search for studies was conducted. The following databases were used: PubMed, Scopus, Web of Science, and the Virtual Health Library (MEDLINE, SciELO, IBECS, and LILACS). The Medical Subject Headings (MeSH) terms "Periapical Periodontitis," "Periapical Abscess," "Polymorphism, Genetic," and "Polymorphism, Single Nucleotide" were used. MeSH synonyms, related terms, and free terms were included. After application of the eligibility criteria, selected studies were qualified by assessment of their methodologic quality. A fixed effects model was used for the meta-analysis. RESULTS: The initial search identified 71 references. After excluding duplicate abstracts, 33 were selected. From these, 6 were eligible for quality assessment; 5 were classified as being of moderate quality, and 1 was classified as being of high quality. CONCLUSIONS: From these included studies, polymorphisms in IL1B, IL6, and IL8 were associated with AP. Polymorphisms in IL1A, IL10, or IL12B were not associated with AP regardless of the methodology used. The meta-analysis suggested that the genotype and allele distribution of IL1B (+3954 C/T) gene polymorphism was different in post-treatment AP. More research in this area is warranted to confirm these results. Copyright © 2017 American Association of Endodontists. Published by Elsevier Inc. All rights reserved. Publication Type Journal Article. Review. Year of Publication 2018 <103> Unique Identifier 29422870 Title Patients with Chronic Obstructive Pulmonary Disease Suffer from Worse Periodontal Health-Evidence from a Meta-Analysis. Source Frontiers in Physiology. 9:33, 2018. VI 1 Status PubMed-not-MEDLINE Authors Shi Q; Zhang B; Xing H; Yang S; Xu J; Liu H. Authors Full Name Shi, Quan; Zhang, Bin; Xing, Helin; Yang, Shuo; Xu, Juan; Liu, Hongchen. Institution Shi, Quan. Department of Stomatology, Chinese PLA General Hospital, Beijing, China. Zhang, Bin. Department of Stomatology, Chinese PLA General Hospital, Beijing, China. Xing, Helin. Department of Stomatology, Chinese PLA General Hospital, Beijing, China. Yang, Shuo. Department of Stomatology, Chinese PLA General Hospital, Beijing, China. Xu, Juan. Department of Stomatology, Chinese PLA General Hospital, Beijing, China. Liu, Hongchen. Department of Stomatology, Chinese PLA General Hospital, Beijing, China. Abstract Background and Objective: It is widely accepted that there is an association between chronic obstructive pulmonary disease (COPD) and periodontitis. However, whether the periodontal status of the COPD patients is worse than that of the non-COPD subjects is seldom assessed. The findings currently available are inconsistent, some even contradictory. Therefore, we performed this meta-analysis to compare the periodontal health status of COPD patients and non-COPD subjects.

Methods: PubMed and Embase were searched for all of the eligible studies which comparing the periodontal status between COPD patients and non-COPD subjects. The results of periodontal parameters in each study were extracted and the mean differences and 95% confidence intervals (CIs) for each parameter were calculated to determine their overall effects. Results: In total, 14 studies involving 3348 COPD patients and 20612 non-COPD controls were included and 9 periodontal indexes were analyzed. The mean differences (95% CIs) between COPD and non-COPD subjects for probing depth, clinical attachment loss, level of alveolar bone loss, plaque index, oral hygiene index, bleeding index, bleeding on probing, gingival index, and remaining teeth were 0.261 (0.020-0.501), 0.480 (0.280-0.681), 0.127 (0.000-0.254), 0.226 (0.043-0.408), 0.802 (0.326-1.279), 0.241 (-0.106 to 0.588), 6.878 (5.489-8.266), 0.364 (0.036-0.692), and -3.726 (-5.120 to -2.331), respectively. Conclusion: In summary, this meta-analysis demonstrates that the COPD patients suffer from worse periodontal health status, indicated by deeper periodontal pockets, high level of clinical attachment loss, worse oral hygiene, more inflammation and bleeding in the gingival tissue, and lower number of remaining teeth. Nevertheless, considering the limitations in our meta-analysis, more high-quality, and well-designed studies focusing on the periodontal health of the COPD patients are required to validate our conclusion. Publication Type Journal Article. Year of Publication 2018 <104> Unique Identifier 29226356 Title Definition of aggressive periodontitis in periodontal research. A systematic review. Source Journal of Clinical Periodontology. 45(3):278-284, 2018 Mar. VI 1 Status In-Data-Review Authors Ramirez V; Hach M; Lopez R. Author NameID Lopez, Rodrigo; ORCID: http://orcid.org/0000-0001-6170-507X Authors Full Name Ramirez, Valeria; Hach, Maria; Lopez, Rodrigo. Institution Ramirez, Valeria. Facultad de Odontologia, Universidad de los Andes, Santiago, Chile. Hach, Maria. School of Oral Health Care and Section of Public Health Dentistry, Department of Odontology, University of Copenhagen, Copenhagen, Denmark. Lopez, Rodrigo. Section of Periodontology, HEALTH, Aarhus University, Aarhus C, Denmark. Local Messages THIS JOURNAL IS AVAILABLE IN THE BDA LIBRARY, TO REQUEST THIS ARTICLE FROM THE LIBRARY GO TO: https://www.bda.org/library/journals-articles/Documents/photocopy-request-form.pdf Abstract Since its introduction in 1999, the term aggressive periodontitis (AgP) has been the topic of many investigations. Articles supporting the International Workshop for a Classification of Periodontal Diseases list several disease features, but do not offer operational criteria for identifying cases. Consequently, considerable variation in the understanding of AgP can be anticipated. AIM: To systematically assess the definitions of AgP reported in original periodontal research. METHODS: A systematic review of original research on AgP published in English. RESULTS: The electronic search yielded 833 abstracts. Of these, 472 publications fulfilled the inclusion criteria and were appraised. In 26.5% of the publications, no information on AgP operationalization is presented, but reference is made to another article. In 12.7% of the publications, no information is provided as to how the cases were defined. Many combinations of criteria for case definition were found. CONCLUSIONS: This study revealed significant heterogeneity in the understanding and use of the term AgP in original research and poor documentation of the identification of cases. The direction and magnitude of the influence of misclassification and selection bias are unknown, but ought to be considered by the critical reader, professionals and patients using this term. Copyright © 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. Publication Type Journal Article. Year of Publication 2018 <105> Unique Identifier 29277978 Title An update of the evidence on the potential impact of periodontal therapy on diabetes outcomes. Source Journal of Clinical Periodontology. 45(2):188-195, 2018 Feb. VI 1 Status

In-Data-Review Authors Madianos PN; Koromantzos PA. Author NameID Madianos, Phoebus N; ORCID: http://orcid.org/0000-0002-5990-5723 Authors Full Name Madianos, Phoebus N; Koromantzos, Panagiotis A. Institution Madianos, Phoebus N. Department of Periodontology, School of Dentistry, National and Kapodistrian University of Athens, Athens, Greece. Koromantzos, Panagiotis A. Department of Periodontology, School of Dentistry, National and Kapodistrian University of Athens, Athens, Greece. Local Messages THIS JOURNAL IS AVAILABLE IN THE BDA LIBRARY, TO REQUEST THIS ARTICLE FROM THE LIBRARY GO TO: https://www.bda.org/library/journals-articles/Documents/photocopy-request-form.pdf Abstract AIM: To provide an update of the systematic review by Engebretson and Kocher J Clin Periodontol. 2013 Apr;40 Suppl 14:S153 on the effect of periodontal therapy on glycaemic control of people with diabetes. METHODS: PubMed Literature search restricted to meta-analyses published from 2013 to the present was conducted. The search resulted in seven meta-analyses of RCTs. RESULTS: Reduction in HbA1c at 3-4 months was reported in all reviews for the treatment group ranging from -0.27% (95% CI: -0.46, -0.07, p = .007) to -1.03% (95% CI: 0.36, -1.70, p = 0.003). At 6 months post-treatment, an HbA1c reduction ranging from -0.02 (95% CI: -0.20, -0.16, p = .84) to -1.18% (95% CI: 0.72%, 1.64%, p < 0.001) was reported. CLINICAL RELEVANCE: The magnitude of the reduction in HbA1c, which is found to be associated with non-surgical periodontal treatment in patients with diabetes, seems to have clinically significant effects on systemic health, and thus should have a place in the treatment of diabetic patients. CONCLUSIONS: Periodontal treatment (SRP) results in a statistically significant reduction in HbA1C levels at 3 months, with a lower reduction at 6 months. Copyright © 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. Publication Type Journal Article. Year of Publication 2018 <106> Unique Identifier 29027242 Title Optimal dose and duration of amoxicillin-plus-metronidazole as an adjunct to non-surgical periodontal therapy: A systematic review and meta-analysis of randomized, placebo-controlled trials. [Review] Source Journal of Clinical Periodontology. 45(1):56-67, 2018 Jan. VI 1 Status In-Process Authors McGowan K; McGowan T; Ivanovski S. Author NameID McGowan, Kelly; ORCID: http://orcid.org/0000-0002-8603-6527 Ivanovski, Saso; ORCID: http://orcid.org/0000-0001-5339-0936 Authors Full Name McGowan, Kelly; McGowan, Troy; Ivanovski, Saso. Institution McGowan, Kelly. School of Dentistry and Oral Health, Griffith University, Southport, Qld, Australia. McGowan, Troy. School of Dentistry and Oral Health, Griffith University, Southport, Qld, Australia. Ivanovski, Saso. School of Dentistry, University of Queensland, Herston, Qld, Australia. Local Messages THIS JOURNAL IS AVAILABLE IN THE BDA LIBRARY, TO REQUEST THIS ARTICLE FROM THE LIBRARY GO TO: https://www.bda.org/library/journals-articles/Documents/photocopy-request-form.pdf Abstract AIM: This systematic review aimed to determine the optimum dose and duration of amoxicillin-plus-metronidazole prescribed as an adjunct to non-surgical treatment of periodontitis. METHODS: Electronic searching identified 376 records, of which 18 were eligible blinded, randomized placebo-controlled trials. The primary outcomes assessed were periodontal pocket depth and clinical attachment level at 3 months, and secondary outcomes were adverse events and compliance. Subgroup analyses were conducted to compare lower and higher doses, and 7- and 14-day courses. RESULTS: Meta-analysis showed a small beneficial effect of adjunctive amoxicillin-plus-metronidazole for each primary outcome, but there was <0.1 mm variation with antibiotic dose or duration. Risk differences for adverse events in the higher dose

and longer duration groups were minimally greater (0.04 and 0.05, respectively), and there was one report of anaphylaxis; 1.3% of patients were not fully compliant. CONCLUSION: There was no clinically meaningful difference between different doses or duration of amoxicillin-plus-metronidazole at 3 months post-treatment. Without compelling evidence to suggest that any one regimen performed superiorly, principles of responsible antibiotic use generally recommend the highest dose for the shortest duration of time to reduce the risk of antibiotic resistance. Therefore, a 7-day regimen of 500/500 mg or 500/400 mg of amoxicillin and metronidazole would be most appropriate. Copyright © 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. Publication Type Journal Article. Review. Year of Publication 2018 <107> Unique Identifier 29277926 Title A systematic review and meta-analysis of epidemiologic observational evidence on the effect of periodontitis on diabetes An update of the EFP-AAP review. [Review] Source Journal of Clinical Periodontology. 45(2):167-187, 2018 Feb. VI 1 Status In-Data-Review Authors Graziani F; Gennai S; Solini A; Petrini M. Author NameID Graziani, Filippo; ORCID: http://orcid.org/0000-0001-8780-7306 Authors Full Name Graziani, Filippo; Gennai, Stefano; Solini, Anna; Petrini, Morena. Institution Graziani, Filippo. Department of Surgical, Medical and Molecular Pathology, Critical Care Medicine, University of Pisa, Pisa, Italy. Graziani, Filippo. Sub-Unit of Periodontology, Halitosis and Periodontal Medicine, University Hospital of Pisa, Pisa, Italy. Gennai, Stefano. Department of Surgical, Medical and Molecular Pathology, Critical Care Medicine, University of Pisa, Pisa, Italy. Gennai, Stefano. Sub-Unit of Periodontology, Halitosis and Periodontal Medicine, University Hospital of Pisa, Pisa, Italy. Solini, Anna. Department of Surgical, Medical and Molecular Pathology, Critical Care Medicine, University of Pisa, Pisa, Italy. Solini, Anna. Sub-Unit of Periodontology, Halitosis and Periodontal Medicine, University Hospital of Pisa, Pisa, Italy. Solini, Anna. Unit of Internal Medicine, University Hospital of Pisa, Pisa, Italy. Petrini, Morena. Department of Surgical, Medical and Molecular Pathology, Critical Care Medicine, University of Pisa, Pisa, Italy. Petrini, Morena. Sub-Unit of Periodontology, Halitosis and Periodontal Medicine, University Hospital of Pisa, Pisa, Italy. Local Messages THIS JOURNAL IS AVAILABLE IN THE BDA LIBRARY, TO REQUEST THIS ARTICLE FROM THE LIBRARY GO TO: https://www.bda.org/library/journals-articles/Documents/photocopy-request-form.pdf Abstract AIM: To update the available evidence on the impact of periodontitis on diabetes control, incidence and complications. METHODS: Observational studies on the effect of periodontitis on diabetes, published after 2012, were identified through electronic databases and hand-searched journals. Findings were summarized by evidence tables, using PRISMA statement. Quality of the included studies was evaluated through the Newcastle Ottawa scale. RESULTS: Healthy individuals with periodontitis exhibit a poor glycaemic control and a higher risk of developing diabetes. Individuals affected by diabetes show a deterioration of glycaemic control if also affected by periodontitis and significantly higher prevalence of diabetes-related complications. Limited evidence is available on gestational diabetes and type 1 diabetes. CONCLUSIONS: Periodontitis has a significant impact on diabetes control, incidence and complications. Nevertheless, the heterogeneity and quality of the included publications suggest that caution should be exercised when interpreting the data and that there remains an important need for additional evidence. Copyright © 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. Publication Type Journal Article. Review. Year of Publication 2018 <108> Unique Identifier 29174279 Title Uncertainty about whether periodontal therapy improves oral health-related quality of life owing to serious limitations in systematic review addressing this question. Source Journal of the American Dental Association. 149(1):e35, 2018 Jan.

VI 1 Status In-Data-Review Authors Brignardello-Petersen R. Authors Full Name Brignardello-Petersen, Romina. Local Messages THIS JOURNAL IS AVAILABLE IN THE BDA LIBRARY, BDA MEMBERS CAN ALSO ACCESS THIS JOURNAL ONLINE FROM 1995 TO DATE. Go to www.bda.org/ejournals Publication Type Journal Article. Year of Publication 2018 <109> Unique Identifier 29946579 Title Cowden Syndrome Associated with Severe Periodontal Disease: A Short Literature Review and a Case Report. [Review] Source Oral Health & Preventive Dentistry. 16(3):225-232, 2018. VI 1 Status MEDLINE Authors Peric M; Toma S; Lasserre JF; Brecx M. Authors Full Name Peric, Marina; Toma, Selena; Lasserre, Jerome Frederic; Brecx, Michel. Abstract PURPOSE: The aim of this literature review and case report was to point out the relationship between Cowden Syndrome (CS) and severe periodontitis. CS is a rare autosomal dominant disorder characterised by skin and oral hamartomas, and is associated with an increased risk of cancer development. CASE REPORT: The case of a 43-year old male patient affected by Cowden syndrome and presenting severe periodontitis was reported. RESULTS: It can be suggested that the specific gingival morphology of the patient with CS might be a risk factor for the development of periodontal disease, as described in the present case report. CONCLUSION: Early diagnosis is crucial in patients affected by CS. The dentist may be the first to notice any atypical changes in the oral cavity and refer the patient for further examinations. Moreover, the mucosal and skin changes have a tendency to appear prior to the malignancies associated with the syndrome. This highlights the responsibility of the dentist in the early diagnosis of this progressive pathological syndrome. Publication Type Case Reports. Journal Article. Review. Year of Publication 2018 <110> Unique Identifier 29966238 Title Interferon Crevicular Fluid Profile and Correlation with Periodontal Disease and Wound Healing: A Systemic Review of Recent Data. [Review] Source International Journal of Molecular Sciences. 19(7), 2018 Jun 29. VI 1 Status MEDLINE Authors Fiorillo L; Cervino G; Herford AS; Lauritano F; D'Amico C; Lo Giudice R; Laino L; Troiano G; Crimi S; Cicciu M. Author NameID Lo Giudice, Roberto; ORCID: https://orcid.org/0000-0002-3529-709X Cicciu, Marco; ORCID: https://orcid.org/0000-0003-2311-9728 Authors Full Name Fiorillo, Luca; Cervino, Gabriele; Herford, Alan Scott; Lauritano, Floriana; D'Amico, Cesare; Lo Giudice, Roberto; Laino, Luigi; Troiano, Giuseppe; Crimi, Salvatore; Cicciu, Marco. Institution Fiorillo, Luca. Department of Biomedical and Dental Sciences and Morphological and Functional Imaging, Messina University, 98122 Messina, Italy. [email protected]. Cervino, Gabriele. Department of Biomedical and Dental Sciences and Morphological and Functional Imaging, Messina University, 98122 Messina, Italy. [email protected]. Herford, Alan Scott. Department of Maxillofacial Surgery, Loma Linda University, Loma Linda, CA 92354, USA. [email protected].

Lauritano, Floriana. Department of Biomedical and Dental Sciences and Morphological and Functional Imaging, Messina University, 98122 Messina, Italy. [email protected]. D'Amico, Cesare. Department of Biomedical and Dental Sciences and Morphological and Functional Imaging, Messina University, 98122 Messina, Italy. [email protected]. Lo Giudice, Roberto. Department of Biomedical and Dental Sciences and Morphological and Functional Imaging, Messina University, 98122 Messina, Italy. [email protected]. Laino, Luigi. Multidisciplinary Department of Medical-Surgical and Odontostomatological Specialties, University of Campania, Luigi Vanvitelli, 80121 Naples, Italy. [email protected]. Troiano, Giuseppe. Clinical and Experimental Medicine, University of Foggia, 71121 Foggia, Italy. [email protected]. Crimi, Salvatore. Department of Surgical and Biomedical Sciences, Catania University, 95124 Catania, Italy. [email protected]. Cicciu, Marco. Department of Biomedical and Dental Sciences and Morphological and Functional Imaging, Messina University, 98122 Messina, Italy. [email protected]. Abstract The purpose of the present study was to see if there is a correlation between the effect of interferons in crevicular fluid and periodontitis, evaluating literature. Interferon gamma (IFN-γ) is an immunoregulatory cytokine that, when activated by its receptor, plays an important role in the activation of inflammatory processes, which are the basis of periodontal disease. Stem cells in the periodontal ligament, like stem cells from other tissues, have immunomodulatory capacity and are regulated by some cytokines such as interferon-γ (IFN-γ). The study searched MEDLINE databases from 2008 to 2018. Clinical human in vitro and in vivo studies had reported a correlation between interferon and periodontitis. The initial search obtained 359 citations. After screening and determination of eligibility, nine articles were included in the review. Significant (p < 0.05) increases in IFN-γ gene expression were observed in some studies in the chronic periodontitis group. In some cases it was suggested that molecular mechanisms underlie the possible roles of IFN-γ in the inhibition of osteoclastogenesis. Neopterin belongs to the chemical group known as pteridines. It is synthesised by human macrophages upon stimulation with the interferon-gamma. Neopterin concentrations in body fluids are high in the case of infections, immune diseases or graft rejection. In the chronic periodontitis group, this marker is significantly higher. These studies underlined the clinical evidence between interferons in the crevicular fluid and inflammatory response of periodontitis. However, there is a lack of scientific evidence that could lead the clinician to an interferon-modulated therapy because of periodontitis. Publication Type Journal Article. Review. Year of Publication 2018 <111> Unique Identifier 29114647 Title The effect of orthodontic treatment on periodontal tissue inflammation: A systematic review. [Review] Source Quintessence International. 49(1):69-77, 2018. VI 1 Status MEDLINE Authors Verrusio C; Iorio-Siciliano V; Blasi A; Leuci S; Adamo D; Nicolo M. Authors Full Name Verrusio, Carmine; Iorio-Siciliano, Vincenzo; Blasi, Andrea; Leuci, Stefania; Adamo, Daniela; Nicolo, Michele. Local Messages THIS JOURNAL IS AVAILABLE IN THE BDA LIBRARY, TO REQUEST THIS ARTICLE FROM THE LIBRARY GO TO: https://www.bda.org/library/journals-articles/Documents/photocopy-request-form.pdf Abstract OBJECTIVE: The aim of the present systematic review was to evaluate the periodontal tissue inflammation indexes in patients undergoing different orthodontic treatment. METHOD AND MATERIALS: The Cochrane Oral Health Group specialist trials, Medline, and Embase databases were used for the research. All the included studies had to report bleeding on probing (BOP) depth as primary outcome. Changes in probing depth, clinical attachment level, Gingival Index, and Periodontal Index were included in the review as secondary outcome measurements. RESULTS: Ten studies reporting on 421 patients and different types of orthodontic treatment were selected for the analysis. Owing to the heterogeneity of studies present in the literature, it was not possible to perform a meta-analysis. CONCLUSION: Within their limits, the results showed an increase of periodontal parameters after orthodontic treatment, indicating that it influences the accumulation and composition of the subgingival microbiota and subsequently induces more inflammation and higher BOP. Publication Type Journal Article. Review. Year of Publication 2018 <112> Unique Identifier 29514641 Title Association between COX2 -765G/C polymorphism and periodontitis in Chinese population: a meta-analysis.

Source BMC Oral Health. 18(1):32, 2018 03 07. VI 1 Status MEDLINE Authors Zhang ZS. Authors Full Name Zhang, Zhan-Shan. Institution Zhang, Zhan-Shan. Department of Stomatology, the First Hospital of Hohhot, Hohhot, Inner Mongolia, 010030, China. [email protected]. Abstract BACKGROUND: Studies had attempted to clarify the relation between COX2 -765G/C gene polymorphisms and periodontitis risk, but there has been no definite consensus to date. A meta-analysis was performed to further explore the relationship of COX2 -765G/C polymorphism on periodontitis risk among Chinese population. METHODS: The databases of PubMed, Springer Link, Ovid, Chinese Wanfang Databases, Chinese National Knowledge Infrastructure (CNKI) and Chinese Biology Medicine were searched up to January 2017. The overall result and subgroup analysis results were combined using fixed-effect or random-effect based on the heterogeneity. RESULTS: Finally, 7 case-control publications including 1399 periodontitis cases and 1663 controls were identified according to the inclusion criteria. In the total analyses, COX2 -765G/C polymorphism had nonsignificant association on periodontitis risk in all models. The subgroup analyses suggested a significantly increased risk of periodontitis in studies with population-based controls and a significantly decreased risk in studies with hospital-based controls. CONCLUSIONS: This meta-analysis indicated that COX2 -765G/C polymorphism had significantly affect on periodontitis risk among Chinese individuals, which should be confirmed by other ethnic groups. Publication Type Journal Article. Meta-Analysis. Year of Publication 2018 <113> Unique Identifier 29396642 Title The effect of statins on periodontal treatment-a systematic review with meta-analyses and meta-regression. [Review] Source Clinical Oral Investigations. 22(2):671-687, 2018 Mar. VI 1 Status MEDLINE Authors Muniz FWMG; Taminski K; Cavagni J; Celeste RK; Weidlich P; Rosing CK. Authors Full Name Muniz, Francisco Wilker Mustafa Gomes; Taminski, Keity; Cavagni, Juliano; Celeste, Roger Keller; Weidlich, Patricia; Rosing, Cassiano Kuchenbecker. Institution Muniz, Francisco Wilker Mustafa Gomes. Department of Periodontology, Faculty of Dentistry, Federal University of Rio Grande do Sul, Porto Alegre, Brazil. Rua Ramiro Barcelos, 2492, Porto Alegre, RS, 90035-003, Brazil. [email protected]. Taminski, Keity. Department of Periodontology, Faculty of Dentistry, Federal University of Rio Grande do Sul, Porto Alegre, Brazil. Rua Ramiro Barcelos, 2492, Porto Alegre, RS, 90035-003, Brazil. Cavagni, Juliano. Department of Periodontology, Faculty of Dentistry, Federal University of Rio Grande do Sul, Porto Alegre, Brazil. Rua Ramiro Barcelos, 2492, Porto Alegre, RS, 90035-003, Brazil. Celeste, Roger Keller. Department of Preventive and Social Dentistry, Faculty of Dentistry, Federal University of Rio Grande do Sul, Porto Alegre, Brazil. Rua Ramiro Barcelos, 2492, Porto Alegre, RS, 90035-003, Brazil. Weidlich, Patricia. Department of Periodontology, Faculty of Dentistry, Federal University of Rio Grande do Sul, Porto Alegre, Brazil. Rua Ramiro Barcelos, 2492, Porto Alegre, RS, 90035-003, Brazil. Rosing, Cassiano Kuchenbecker. Department of Periodontology, Faculty of Dentistry, Federal University of Rio Grande do Sul, Porto Alegre, Brazil. Rua Ramiro Barcelos, 2492, Porto Alegre, RS, 90035-003, Brazil. Local Messages THIS JOURNAL IS AVAILABLE IN THE BDA LIBRARY, TO REQUEST THIS ARTICLE FROM THE LIBRARY GO TO: https://www.bda.org/library/journals-articles/Documents/photocopy-request-form.pdf Abstract OBJECTIVE: This study aimed to systematically review clinical trials about the effect of statins as adjunct to mechanical periodontal therapy, on probing pocket depth, clinical attachment level, and intrabony defects, in comparison to mechanical periodontal therapy alone or in association with placebo. MATERIAL AND METHODS: Three databases were searched for controlled clinical trials that used any locally delivered or systemically statin as a sole adjunctive therapy to mechanical periodontal treatment. Weighted mean differences between baseline and 6 months after periodontal treatment for clinical attachment level (CAL), probing pocket depth (PPD), and intrabony defect (IBD) were calculated. A high heterogeneity was detected. Therefore, a meta-regression adjusted for type of statin and year of publication was performed.

RESULTS: Fifteen studies were included in the systematic review, and ten studies were included in the meta-analysis. In the meta-regression, the adjunct use of simvastatin, rosuvastatin, and atorvastatin additionally reduced PPD in comparison to mechanical periodontal therapy and a placebo gel (2.90 +/- 0.35, 3.90 +/- 0.77, 3.06 +/- 0.71 mm, respectively; p < 0.05). Regarding the resolution of IBD, simvastatin and rosuvastatin significantly improved in comparison to control group (0.89 +/- 0.35 and 1.93 +/- 0.77 mm, respectively; p < 0.05). No statistically significant difference was found between the statins for both PPD and IBD (p < 0.05). Regarding CAL gain, simvastatin provided a statistically significant improvement as compared to the control group (2.02 +/- 0.79 mm; p = 0.043). CONCLUSIONS: The use of statins, used as sole adjuncts to mechanical periodontal treatment, improved the periodontal parameters. In the quantitative analyses, simvastatin was the only drug that showed additional benefits in all evaluated parameters. CLINICAL RELEVANCE: Statins promote significantly clinical periodontal improvements when administered in association with non-surgical scaling and root planning (SRP), when compared to SRP alone or in association with a placebo. Publication Type Journal Article. Meta-Analysis. Review. Year of Publication 2018 <114> Unique Identifier 29288920 Title Diagnostic potential and future directions of biomarkers in gingival crevicular fluid and saliva of periodontal diseases: Review of the current evidence. [Review] Source Archives of Oral Biology. 87:115-124, 2018 Mar. VI 1 Status MEDLINE Authors Ghallab NA. Authors Full Name Ghallab, Noha Ayman. Institution Ghallab, Noha Ayman. Periodontology and Oral Medicine, Faculty of Dentistry, Cairo University, Egypt. Electronic address: [email protected]. Local Messages THIS JOURNAL IS AVAILABLE IN THE BDA LIBRARY UP TO 2014, TO REQUEST THIS ARTICLE FROM THE LIBRARY GO TO: https://www.bda.org/library/journals-articles/Documents/photocopy-request-form.pdf Abstract OBJECTIVES: The holy grail of biomarker research in periodontology is to develop a high impact diagnostics which have a significant impact on clinical decision-making, patient outcomes and healthcare providers. In the field of periodontal diagnostics, oral fluid-based biomarkers have been studied mainly in the gingival crevicular fluid (GCF) and saliva. METHODS: A literature search was performed using the Cochrane library and PubMed databases from 2000 to January 2017. RESULTS: Currently, there are more than 90 different components in the GCF that have been investigated as diagnostic and prognostic markers of periodontal disease progression involving; inflammatory mediators, markers of oxidative stress, host-derived enzymes, tissue-breakdown products and mediators of bone homeostasis. Furthermore, various biomarkers in saliva have been proposed which reveal a promising outlook for saliva as a key diagnostic medium for periodontal disease. Recent systematic reviews with high value of evidence have shown that potential salivary biomarkers can provide important complimentary diagnostic information and can be used as tests for screening diagnosis, prognosis and predicting periodontal disease progression. CONCLUSION: Future developments in proteomic analysis and personalized medicine will pave the way allowing novel diagnostic tools. Still, the application into the field of dentistry will depend on how practitioners will apply this into their daily clinical practice. CLINICAL RELEVANCE: Still, the application into the field of dentistry will depend on how practitioners will apply this into their daily clinical practice. Copyright © 2017 Elsevier Ltd. All rights reserved. Publication Type Journal Article. Review. Year of Publication 2018 <115> Unique Identifier 29248700 Title Matrix metalloproteinase-8 analysis in patients with periodontal disease with prediabetes or type 2 diabetes mellitus: A systematic review. [Review] Source Archives of Oral Biology. 87:43-51, 2018 Mar.

VI 1 Status MEDLINE Authors de Morais EF; Dantas AN; Pinheiro JC; Leite RB; Galvao Barboza CA; de Vasconcelos Gurgel BC; de Almeida Freitas R. Authors Full Name de Morais, Everton Freitas de; Dantas, Afonso Nobrega; Pinheiro, Juliana Campos; Leite, Rafaella Bastos; Galvao Barboza, Carlos Augusto; de Vasconcelos Gurgel, Bruno Cesar; de Almeida Freitas, Roseana. Institution de Morais, Everton Freitas de. Postgraduate Program, Oral Pathology, Federal University of Rio Grande do Norte, Natal, Rio Grande do Norte, Brazil. Electronic address: [email protected]. Dantas, Afonso Nobrega. Postgraduate Program, Oral Pathology, Federal University of Rio Grande do Norte, Natal, Rio Grande do Norte, Brazil. Pinheiro, Juliana Campos. Postgraduate Program, Oral Pathology, Federal University of Rio Grande do Norte, Natal, Rio Grande do Norte, Brazil. Leite, Rafaella Bastos. Postgraduate Program, Oral Pathology, Federal University of Rio Grande do Norte, Natal, Rio Grande do Norte, Brazil. Galvao Barboza, Carlos Augusto. Postgraduate Program in Oral Pathology, Federal University of Rio Grande do Norte, Natal, Rio Grande do Norte, Brazil. de Vasconcelos Gurgel, Bruno Cesar. Postgraduate Program in Oral Pathology, Federal University of Rio Grande do Norte, Natal, Rio Grande do Norte, Brazil. de Almeida Freitas, Roseana. Postgraduate Program in Oral Pathology, Federal University of Rio Grande do Norte, Natal, Rio Grande do Norte, Brazil. Local Messages THIS JOURNAL IS AVAILABLE IN THE BDA LIBRARY UP TO 2014, TO REQUEST THIS ARTICLE FROM THE LIBRARY GO TO: https://www.bda.org/library/journals-articles/Documents/photocopy-request-form.pdf Abstract OBJECTIVES: The objective of this systematic review was to evaluate information on the levels of MMP-8 in patients diagnosed with prediabetes or type 2 diabetes mellitus with periodontal disease, analyzing its validity as a possible biomarker for the diagnosis and progression of periodontal disease (PD). METHODS: A systematic search of the following databases was performed: PubMed/Medline, CENTRAL (The Cochrane Library), EMBASE and Web of Science. Studies involving the evaluation of MMP-8 in patients with prediabetes or patients presenting type 2 diabetes mellitus concomitantly with PD were selected. The evaluation of the methodological quality of the selected studies was based on the methodological bias risk analysis (QUADAS-2). RESULTS: Eight of the initially identified 2683 articles were selected. In all the selected studies, evaluator calibration and the use of clear methods for patient diagnosis with periodontal disease were present. Studies have demonstrated significantly higher MMP-8 concentrations in PD patients compared to controls, as well as in patients presenting more advanced stages of PD. However, controversies regarding MMP-8 levels in prediabetes/diabetes type 2 patients with PD. CONCLUSIONS: Higher MMP-8 levels in patients with PD compared to controls imply the potential use of MMP-8 in the diagnosis of PD. The influence of patient glycemic state, as well as medications these patients make use of, are factors that possibly contribute to the modulation of MMP-8 concentrations in patients with diabetes and should be analyzed, aiming at a better understanding of the relationship between glycemic state and MMP-8 levels in patients with PD. Copyright © 2017 Elsevier Ltd. All rights reserved. Publication Type Journal Article. Review. Year of Publication 2018 <116> Unique Identifier 30024992 Title Prevalence of Peri-implant Disease According to Periodontal Probing Depth and Bleeding on Probing: A Systematic Review and Meta-Analysis. [Review] Source International Journal of Oral & Maxillofacial Implants. 33(4):e89-e105, 2018 Jul/Aug. VI 1 Status MEDLINE Authors Munoz V; Duque A; Giraldo A; Manrique R. Authors Full Name Munoz, Viviana; Duque, Andres; Giraldo, Astrid; Manrique, Ruben. Local Messages THIS JOURNAL IS AVAILABLE IN THE BDA LIBRARY, TO REQUEST THIS ARTICLE FROM THE LIBRARY GO TO: https://www.bda.org/library/journals-articles/Documents/photocopy-request-form.pdf Abstract PURPOSE: To compare changes in the prevalence of peri-implantitis when the unit of analysis is the subject and when the unit of analysis is the implant, by means of meta-analysis with subgroup and sensitivity analyses, according to the case definition and cutoffs. Periodontal probing depth (PPD) and bleeding on probing (BOP) were considered the primary variables.

MATERIALS AND METHODS: Electronic and manual searches of observational studies of implants with loading of more than 6 months were conducted. The quality of the studies was evaluated, and finally, a description (qualitative analysis) and a meta-analysis (quantitative analysis) of the available studies were performed. RESULTS: Fifty-five studies were included in this systematic review, 32 of which met the criteria for evaluation of disease based on PPD and BOP. A total of 2,734 subjects and 7,849 implants were evaluated. The prevalence of peri-implantitis, defined by PPD and BOP, was 17% when the unit of analysis was the subject, and 11% when it was the implant. If the clinical criterion was PPD >= 4 mm, the prevalence by subject was 34% and by implant 11%. If PPD was >= 5 mm, the prevalence by subject was 12% and by implant 10%. Finally, if the clinical criterion was PPD >= 6 mm, the prevalence by subject was 18% and by implant 10%. CONCLUSION: The prevalence of peri-implantitis is influenced by the criteria used for the case definition, and the true prevalence may currently be incorrectly estimated. Publication Type Journal Article. Meta-Analysis. Review. Year of Publication 2018 <117> Unique Identifier 29857875 Title Protective role of flavonoid baicalin from Scutellaria baicalensis in periodontal disease pathogenesis: A literature review. [Review] Source Complementary Therapies in Medicine. 38:11-18, 2018 Jun. VI 1 Status MEDLINE Authors Ming J; Zhuoneng L; Guangxun Z. Authors Full Name Ming, Jiang; Zhuoneng, Li; Guangxun, Zhu. Institution Ming, Jiang. Department of Stomatology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, No.1095 Jiefang Road, Wuhan, Hubei, 430030, China. Zhuoneng, Li. Centers for Disease Control and Prevention of Wuhan, China. Guangxun, Zhu. Department of Stomatology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, No.1095 Jiefang Road, Wuhan, Hubei, 430030, China. Electronic address: [email protected]. Abstract INTRODUCTION: Periodontal disease is characterized by a chronic infection, leading to the irreversible destruction of tissues supporting the teeth. Bacteria, pro-inflammatory mediators and host immune response play important role in the progress of periodontal disease. Baicalin is a bioactive flavone extracted from the dry raw root of Scutellaria baicalensis, with pharmaceutical actions of anti-inflammation, anti-oxidants, anti-tumor, antivirus, and so on. The present review summarizes the efficacy of baicalin in periodontal treatment. METHODS: A computer-based literature search was carried out using Pubmed, Scopus and Web of Science to identify papers published until 2017. Keywords used in the search were "baicalin"/"baicalein" and various words related to periodontal disease (periodontal, periodontitis, periodontal tissue, gingival, gingivitis, gingival tissue, periodontal disease, gingival disease, gingiva, periodontium). RESULTS: A total of 28 original studies were found, including 3 bacteriological studies, 7 zoological studies and 18 cytological studies. 15 of them were published in English and 13 of them were published in Chinese. Results from these 28 studies could not be pooled to conduct meta-analysis due to the heterogeneity. The pharmacological properties and mechanisms of baicalin for treating periodontal disease is mainly focused on five aspects: antibacterial effect on putative periodontopathic bacteria, protective effect on periodontal tissues, regulatory effect on pro-inflammatory mediators and matrix metalloproteinases, and regulatory effect on innate immune response. CONCLUSIONS: Baicalin have been shown to possess multiple pharmacological activities in periodontal tissues. However, the underlying mechanisms have not been fully defined. Further researches are needed to provide more scientific evidence for the clinical periodontal treatment. Copyright © 2018 Elsevier Ltd. All rights reserved. Publication Type Journal Article. Review. Year of Publication 2018 <118> Unique Identifier 29447324 Title Accuracy and Usefulness of CBCT in Periodontology: A Systematic Review of the Literature. [Review] Source International Journal of Periodontics & Restorative Dentistry. 38(2):289-297, 2018 Mar/Apr. VI 1 Status

MEDLINE Authors Woelber JP; Fleiner J; Rau J; Ratka-Kruger P; Hannig C. Authors Full Name Woelber, Johan Peter; Fleiner, Jonathan; Rau, Julia; Ratka-Kruger, Petra; Hannig, Christian. Local Messages THIS JOURNAL IS AVAILABLE IN THE BDA LIBRARY, TO REQUEST THIS ARTICLE FROM THE LIBRARY GO TO: https://www.bda.org/library/journals-articles/Documents/photocopy-request-form.pdf Abstract A systematic literature review was performed regarding the accuracy and usefulness of cone beam computed tomography (CBCT) in the field of periodontology. A total of 580 articles were identified, of which 13 met the inclusion criteria. Results showed a high accuracy of CBCT in visualizing periodontal structures and the demonstrated the usefulness of CBCT in regenerative periodontal surgery of maxillary molars. It remains questionable whether this gain of additional information actually leads to a better clinical outcome in periodontal treatment. Currently, the use of CBCT in periodontology should be restricted to complex periodontal cases, particularly those involving maxillary molars. Publication Type Journal Article. Review. Year of Publication 2018 <119> Unique Identifier 29783781 Title Nutraceuticals in Periodontal Health: A Systematic Review on the Role of Vitamins in Periodontal Health Maintenance. [Review] Source Molecules. 23(5), 2018 May 20. VI 1 Status MEDLINE Authors Varela-Lopez A; Navarro-Hortal MD; Giampieri F; Bullon P; Battino M; Quiles JL. Author NameID Varela-Lopez, Alfonso; ORCID: https://orcid.org/0000-0002-0504-5086 Giampieri, Francesca; ORCID: https://orcid.org/0000-0002-8151-9132 Bullon, Pedro; ORCID: https://orcid.org/0000-0003-4873-4196 Battino, Maurizio; ORCID: https://orcid.org/0000-0002-7250-1782 Quiles, Jose L; ORCID: https://orcid.org/0000-0002-9048-9086 Authors Full Name Varela-Lopez, Alfonso; Navarro-Hortal, Maria D; Giampieri, Francesca; Bullon, Pedro; Battino, Maurizio; Quiles, Jose L. Institution Varela-Lopez, Alfonso. Dipartimento di Scienze Cliniche Specialistiche ed Odontostomatologiche (DISCO)-Sez. Biochimica, Facolta di Medicina, Universita Politecnica delle Marche, 60131 Ancona, Italy. [email protected]. Navarro-Hortal, Maria D. Department of Physiology, Institute of Nutrition and Food Technology "Jose Mataix", Biomedical Research Center, University of Granada, Avda. Conocimiento s/n, 18100 Armilla, Granada, Spain. [email protected]. Giampieri, Francesca. Dipartimento di Scienze Cliniche Specialistiche ed Odontostomatologiche (DISCO)-Sez. Biochimica, Facolta di Medicina, Universita Politecnica delle Marche, 60131 Ancona, Italy. [email protected]. Bullon, Pedro. Department of Stomalogy, Dental School, University of Sevilla, C/Avicena s.n., 41009 Sevilla, Spain. [email protected]. Battino, Maurizio. Dipartimento di Scienze Cliniche Specialistiche ed Odontostomatologiche (DISCO)-Sez. Biochimica, Facolta di Medicina, Universita Politecnica delle Marche, 60131 Ancona, Italy. [email protected]. Quiles, Jose L. Department of Physiology, Institute of Nutrition and Food Technology "Jose Mataix", Biomedical Research Center, University of Granada, Avda. Conocimiento s/n, 18100 Armilla, Granada, Spain. [email protected]. Abstract Periodontal disease, a relevant public health problem worldwide, is generally considered a common pathology of elderly people. In this respect, there is agreement about that nutritional status may be a modifying factor in the progression and healing of the periodontal tissues. Vitamins have been recommended as nutraceuticals for prevention and treatment of some pathological conditions, such as cardiovascular diseases, obesity or cancer. Thus, a systematic approach to determining how the different vitamin type could ameliorate periodontal risks or improve periodontal health is necessary to further the understanding of the potential benefits and risks of vitamins supplementation use. For this, a systematic review of English-written literature in PubMed until February 2018, which included both human and animal research on the relationship of each vitamin with periodontal disease, was conducted. Among all the analyzed vitamins those with antioxidant capacity and effects on immune system seem to be useful for prevention or improvement of periodontal disease, as well as those implicated in bone metabolism. In the first case, there are quite information in favor of various vitamins, mainly vitamin C, that is the most studied. In the second case, vitamin D seems to have the most relevant role. Publication Type Journal Article. Review. Year of Publication 2018 <120> Unique Identifier 29854026 Title

Meta-Analysis of the Use of 8-OHdG in Saliva as a Marker of Periodontal Disease. [Review] Source Disease Markers. 2018:7916578, 2018. VI 1 Status MEDLINE Authors Paredes-Sanchez E; Montiel-Company JM; Iranzo-Cortes JE; Almerich-Torres T; Bellot-Arcis C; Almerich-Silla JM. Author NameID Montiel-Company, Jose Maria; ORCID: https://orcid.org/0000-0002-3952-7681 Authors Full Name Paredes-Sanchez, Esther; Montiel-Company, Jose Maria; Iranzo-Cortes, Jose Enrique; Almerich-Torres, Teresa; Bellot-Arcis, Carlos; Almerich-Silla, Jose Manuel. Institution Paredes-Sanchez, Esther. Departamento de Estomatologia, Facultad de Medicina y Odontologia, Universidad de Valencia, C/ Gasco Oliag num. 1, 46010 Valencia, Spain. Montiel-Company, Jose Maria. Departamento de Estomatologia, Facultad de Medicina y Odontologia, Universidad de Valencia, C/ Gasco Oliag num. 1, 46010 Valencia, Spain. Iranzo-Cortes, Jose Enrique. Departamento de Estomatologia, Facultad de Medicina y Odontologia, Universidad de Valencia, C/ Gasco Oliag num. 1, 46010 Valencia, Spain. Almerich-Torres, Teresa. Departamento de Estomatologia, Facultad de Medicina y Odontologia, Universidad de Valencia, C/ Gasco Oliag num. 1, 46010 Valencia, Spain. Bellot-Arcis, Carlos. Departamento de Estomatologia, Facultad de Medicina y Odontologia, Universidad de Valencia, C/ Gasco Oliag num. 1, 46010 Valencia, Spain. Almerich-Silla, Jose Manuel. Departamento de Estomatologia, Facultad de Medicina y Odontologia, Universidad de Valencia, C/ Gasco Oliag num. 1, 46010 Valencia, Spain. Abstract The objective was to collect the available evidence on oxidative stress marker measurements in periodontal patients, focusing specifically on 8-hydroxy-2'-deoxyguanosine (8-OHdG) as a salivary marker of periodontal disease, and to perform meta-analyses to calculate differences in concentration compared to healthy persons. A systematic search in PubMed, Cochrane Library, Embase, and Scopus identified 81 articles. Of these, 38 were duplicates. After reading the abstracts of the remaining 43, 42 were selected for full-text assessment. Finally, 17 articles were included in the qualitative synthesis. Those excluded were of low quality, did not answer the research question, or did not meet the inclusion and exclusion criteria. Of the 17 in the qualitative synthesis, 9 were included in the meta-analysis. The 9 studies in the meta-analysis were combined in a random effects model. Their heterogeneity was high (Q = 3982.02, p < 0.001, I2 = 99.8%). The difference in mean 8-OHdG concentration in saliva between periodontal and healthy subjects was estimated at 2.11 ng/ml (95% CI 1.23-2.98). The different saliva collection methods (stimulated/unstimulated) did not explain the heterogeneity. The 8-OHdG levels in saliva of periodontal patients were almost double to those of healthy patients: 8-OHdG is clearly a powerful periodontal disease marker. Publication Type Journal Article. Meta-Analysis. Review. Year of Publication 2018 <121> Unique Identifier 27030114 Title Association Between Periodontal Disease and Erectile Dysfunction: A Systematic Review. [Review] Source American Journal of Mens Health. 12(2):338-346, 2018 03. VI 1 Status MEDLINE Authors Kellesarian SV; Kellesarian TV; Ros Malignaggi V; Al-Askar M; Ghanem A; Malmstrom H; Javed F. Authors Full Name Kellesarian, Sergio Varela; Kellesarian, Tammy Varela; Ros Malignaggi, Vanessa; Al-Askar, Mansour; Ghanem, Alexis; Malmstrom, Hans; Javed, Fawad. Institution Kellesarian, Sergio Varela. 1 University of Rochester, Rochester, NY, USA. Kellesarian, Tammy Varela. 2 Barry University, Miami Shores, FL, USA. Ros Malignaggi, Vanessa. 3 Universidad Santa Maria, Caracas, Venezuela. Al-Askar, Mansour. 4 King Saud University, Riyadh, Saudi Arabia. Ghanem, Alexis. 1 University of Rochester, Rochester, NY, USA. Malmstrom, Hans. 1 University of Rochester, Rochester, NY, USA. Javed, Fawad. 1 University of Rochester, Rochester, NY, USA. Abstract A limited number of studies have reported an association between erectile dysfunction (ED) and chronic periodontitis (CP). The aim of the present study is to assess the association between CP and ED through a systematic review of published literature. To address the focused question, "Is there a relationship between ED and CP?" indexed databases were searched till December 2015 using various key words "erectile dysfunction," "periodontal disease," "periodontitis," "dental infection," and "impotence." Letters to the editor, commentaries, historic reviews, and experimental studies were excluded. The pattern of the present systematic review was customized to primarily summarize the pertinent data. Nine studies were included. Seven studies had a cross-sectional design and two studies were randomized control trials. The number of study participants ranged between 53 and 513,258 individuals with age ranging between 20 years and 85 years (median age ranging between 34.9 +/- 4.9 years and 50.9 +/-

16.6 years). In all studies, a positive relationship between CP and ED was reported. In four studies, odds ratio were reported, ranging between 1.53 and 3.35. From the literature reviewed, there seems to be a positive association between ED and CP; however, further well-designed controlled clinical trials are needed in this regard. It is emphasized that physicians should refer patients with ED to oral health care providers for a comprehensive oral evaluation and treatment. Publication Type Journal Article. Review. Year of Publication 2018 <122> Unique Identifier 28985086 Title Gingival melanin depigmentation by Er:YAG laser: A literature review. [Review] Source Journal of Cosmetic & Laser Therapy. 20(2):85-90, 2018 Apr. VI 1 Status MEDLINE Authors Pavlic V; Brkic Z; Marin S; Cicmil S; Gojkov-Vukelic M; Aoki A. Author NameID Pavlic, Verica; ORCID: http://orcid.org/0000-0001-6737-6449 Authors Full Name Pavlic, Verica; Brkic, Zlata; Marin, Sasa; Cicmil, Smiljka; Gojkov-Vukelic, Mirjana; Aoki, Akira. Institution Pavlic, Verica. a Department of Periodontology and Oral Medicine , Institute of Dentistry , Banja Luka , Bosnia and Herzegovina. Pavlic, Verica. b Department of Periodontology and Oral Medicine, Medical Faculty , University of Banja Luka , Banja Luka , Bosnia and Herzegovina. Brkic, Zlata. c Department of Periodontology and Oral Medicine , Militar Medical Academy , Belgrade , Serbia. Marin, Sasa. d Department of Oral Surgery, Medical Faculty , University of Banja Luka , Banja Luka , Bosnia and Herzegovina. Cicmil, Smiljka. e Department of Periodontology and Oral Medicine, Medical Faculty , University of East Sarajevo , Foca , Bosnia and Herzegovina. Gojkov-Vukelic, Mirjana. f Department of Periodontology and Oral Medicine, Faculty of Dentistry , University of Sarajevo , Sarajevo, Bosnia and Herzegovina. Aoki, Akira. g Section of Periodontology, Department of Hard Tissue Engineering , Tokyo Medical and Dental University , Tokyo , Japan. Abstract Laser ablation is recently suggested as a most effective and reliable technique for depigmentation of melanin hyperpigmented gingiva. To date, different lasers have been used for gingival depigmentation (CO2, diode, Nd:YAG, Er:YAG and Er,Cr:YSGG lasers). The use of Er:YAG laser for depigmentation of melanin hyperpigmented gingiva has gained increasing importance in recent years. The purpose of this study was to report removal of gingival melanin pigmentation using an Er:YAG laser in a literature review. The main outcomes, such as improvement of signs (clinical parameters of bleeding, erythema, swelling and wound healing), symptoms (pain) and melanin recurrence/repigmentation were measured. The literature demonstrated that depigmentation of gingival melanin pigmentation can be performed safely and effectively by Er:YAG laser resulting in healing and an esthetically significant improvement of gingival discoloration. Thus, Er:YAG laser seems to be safe and useful in melanin depigmentation procedure. However, the main issue in giving the final conclusion of the optimal Er:YAG laser use in melanin depigmentation is that, to date, studies are offering completely discrepant Er:YAG laser procedure protocols (complex settings of laser parameters), and different criteria for the assessment of depigmentation and repigmentation (recurrence), thus hampering the comparison of the results. Therefore, further studies are necessary to give an optimal recommendation on the use of Er:YAG laser in gingival melanin hyperpigmentation. Publication Type Journal Article. Review. Year of Publication 2018 <123> Unique Identifier 29655406 Title Aggregatibacter (Actinobacillus) actimycetemcomitans leukotoxin and human periodontitis - A historic review with emphasis on JP2. [Review] Source Kaohsiung Journal of Medical Sciences. 34(4):186-193, 2018 Apr. VI 1 Status MEDLINE Authors Tsai CC; Ho YP; Chou YS; Ho KY; Wu YM; Lin YC. Authors Full Name Tsai, Chi-Cheng; Ho, Ya-Ping; Chou, Yu-Shian; Ho, Kun-Yen; Wu, Yi-Min; Lin, Ying-Chu. Institution Tsai, Chi-Cheng. School of Dentistry, College of Oral Medicine, University Hospital, Chung Shan Medical University, Taichung City, Taiwan. Electronic address: [email protected].

Ho, Ya-Ping. College of Dental Medicine, Kaohsiung Medical University, Kaohsiung City, Taiwan; Division of Periodontics, Kaohsiung Medical University Hospital, Kaohsiung City, Taiwan. Chou, Yu-Shian. Division of Periodontics, Kaohsiung Medical University Hospital, Kaohsiung City, Taiwan. Ho, Kun-Yen. College of Dental Medicine, Kaohsiung Medical University, Kaohsiung City, Taiwan; Division of Periodontics, Kaohsiung Medical University Hospital, Kaohsiung City, Taiwan. Wu, Yi-Min. College of Dental Medicine, Kaohsiung Medical University, Kaohsiung City, Taiwan; Division of Periodontics, Kaohsiung Medical University Hospital, Kaohsiung City, Taiwan. Lin, Ying-Chu. College of Dental Medicine, Kaohsiung Medical University, Kaohsiung City, Taiwan. Abstract Aggregatibacter (Actinobacillus) actimycetemcomitans (Aa) is a gram-negative bacterium that colonizes the human oral cavity and is causative agent for localized aggressive (juvenile) periodontitis (AgP). In the middle of 1990s, a specific JP2 clone of belonging to the cluster of serotype b strains of Aa with highly leukotoxicity (leukotoxin, LtxA) able to kill human immune cells was isolated. JP2 clone of Aa was strongly associated with in particularly in rapidly progressing forms of aggressive periodontitis. The JP2 clone of Aa is transmitted through close contacts. Therefore, AgP patients need intense monitoring of their periodontal status as the risk for developing severely progressing periodontitis lesions are relatively high. Furthermore, timely periodontal treatment, including periodontal surgery supplemented by the use of antibiotics, is warranted. More importantly, periodontal attachment loss should be prevented by early detection of the JP2 clone of Aa by microbial diagnosis testing and/or preventive means. Copyright © 2018. Published by Elsevier Taiwan. Publication Type Historical Article. Journal Article. Review. Year of Publication 2018 <124> Unique Identifier 28872188 Title Does the adjunctive use of statins provide additional benefits to nonsurgical periodontal treatment? A systematic review and meta-analysis. [Review] Source Journal of Periodontal Research. 53(1):12-21, 2018 Feb. VI 1 Status MEDLINE Authors Ambrosio LMB; Rovai ES; Sendyk DI; Holzhausen M; Pannuti CM. Author NameID Ambrosio, L M B; ORCID: http://orcid.org/0000-0002-2494-1513 Authors Full Name Ambrosio, L M B; Rovai, E S; Sendyk, D I; Holzhausen, M; Pannuti, C M. Institution Ambrosio, L M B. Department of Stomatology, Division of Periodontics, Faculty of Dentistry, University of Sao Paulo, Sao Paulo, Brazil. Rovai, E S. Department of Stomatology, Division of Periodontics, Faculty of Dentistry, University of Sao Paulo, Sao Paulo, Brazil. Sendyk, D I. Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, University of Sao Paulo, Sao Paulo, Brazil. Holzhausen, M. Department of Stomatology, Division of Periodontics, Faculty of Dentistry, University of Sao Paulo, Sao Paulo, Brazil. Pannuti, C M. Department of Stomatology, Division of Periodontics, Faculty of Dentistry, University of Sao Paulo, Sao Paulo, Brazil. Local Messages THIS JOURNAL IS AVAILABLE IN THE BDA LIBRARY, TO REQUEST THIS ARTICLE FROM THE LIBRARY GO TO: https://www.bda.org/library/journals-articles/Documents/photocopy-request-form.pdf Abstract Adjunctive therapeutic agents may be used to improve the response to nonsurgical periodontal therapy. Local delivery of statins (simvastatin, artovastatin and rosuvastatin) is a promising adjunct to scaling and root planing (SRP). Thus, the aim of this review is to evaluate if adjunctive local delivery of statins is more effective than SRP alone. Randomized clinical trials that presented a test group evaluating local delivery of statins as adjuncts in healthy, diabetic and smoking patients were included. Medline and the Cochrane library database were searched up to November 2016. Random effects meta-analyses were conducted for pocket depth change and clinical attachment gain. One hundred and twenty-five studies potentially related to the aim of this review were screened, but only 10 were included. The majority of the trials reported additional clinical benefits in the groups that were treated with adjunctive local delivery of statins. Pooled calculations showed that local delivery of statins resulted in additional reduction of pocket depth and clinical attachment gain in healthy people, smokers and diabetic patients. Local statins may offer additional clinical benefits to SRP, even in smokers and diabetics. Copyright © 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. Publication Type Journal Article. Meta-Analysis. Review. Year of Publication 2018 <125> Unique Identifier 28836329

Title The effect of professional tooth cleaning or non-surgical periodontal therapy on oral halitosis in patients with periodontal diseases. A systematic review. [Review] Source International Journal of Dental Hygiene. 16(1):36-47, 2018 Feb. VI 1 Status MEDLINE Authors Deutscher H; Derman S; Barbe AG; Seemann R; Noack MJ. Author NameID Deutscher, Hcd; ORCID: http://orcid.org/0000-0002-2767-9290 Derman, Shm; ORCID: http://orcid.org/0000-0003-2239-6010 Barbe, A G; ORCID: http://orcid.org/0000-0003-0169-2582 Authors Full Name Deutscher, Hcd; Derman, Shm; Barbe, A G; Seemann, R; Noack, M J. Institution Deutscher, Hcd. Department of Operative Dentistry and Periodontology, University of Cologne, Cologne, Germany. Derman, Shm. Department of Operative Dentistry and Periodontology, University of Cologne, Cologne, Germany. Barbe, A G. Department of Operative Dentistry and Periodontology, University of Cologne, Cologne, Germany. Seemann, R. Department of Preventive-, Restorative - and Pediatric Dentistry, zmk Bern, University Bern, Switzerland. Noack, M J. Department of Operative Dentistry and Periodontology, University of Cologne, Cologne, Germany. Abstract OBJECTIVE: The aim of this systematic review was to give the best available evidence on the impact of professional tooth cleaning (PTC) and scaling and root planing (SRP) on oral halitosis in patients with periodontal diseases. MATERIAL AND METHODS: Three databases were screened for relevant studies. Only randomized controlled trials (RCTs) or controlled clinical trials (CCT) were included. The primary outcome in all included studies was volatile sulphur compounds (VSC) measured by Halimeter or OralChroma and organoleptic scores as secondary outcome. Only studies investigating healthy adults except for periodontitis or gingivitis were included. The considered intervention strategies were professional tooth cleaning and non-surgical periodontal treatment. For both strategies, additional oral hygiene instructions (OHI) were possible. Two independent reviewers performed the study selection and quality assessment. SEARCH RESULTS: After abstract and title screening and subsequent full-text reading of potential papers, a placebo-controlled RCT could not be found. However, eight studies or particular arms used PTC or SRP as sole interventions and were included in this review. All trials or study arms included showed a positive effect on VSC levels or organoleptic scores after intervention. CONCLUSIONS: Based on best available evidence, PTC and SRP in combination with oral hygiene instructions reduced VSC values in patients with oral halitosis and/or periodontal diseases, independent of tongue cleaning and the use of mouth rinses. Copyright © 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. Publication Type Journal Article. Review. Year of Publication 2018 <126> Unique Identifier 28544259 Title Periodontal maintenance following active specialist treatment: Should patients stay put or return to primary dental care for continuing care? A comparison of outcomes based on the literature. [Review] Source International Journal of Dental Hygiene. 16(1):68-77, 2018 Feb. VI 1 Status MEDLINE Authors Leavy PG; Robertson DP. Author NameID Leavy, P G; ORCID: http://orcid.org/0000-0002-8297-3249 Authors Full Name Leavy, P G; Robertson, D P. Institution Leavy, P G. Department of Restorative Dentistry, Charles Clifford Dental Hospital, Sheffield, UK. Robertson, D P. Department of Restorative Dentistry, Glasgow Dental School, School of Medicine, College of Medicine, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK. Abstract OBJECTIVES: To review the evidence for the efficacy of periodontal maintenance (PM) carried out in primary dental care (PDC) compared to the specialist setting for patients previously treated in a specialist setting for chronic (ChP) or aggressive (AgP) periodontitis. METHODS: A focused PICO question and search protocol were developed. Online databases including MEDLINE, EMBASE, WEB OF SCIENCETM and COCHRANE LIBRARY were searched along with specialist journals in the subject area of periodontal research. Selection criteria included studies that investigated delivery of PM in both specialist and PDC settings for patients with

ChP or AgP over a minimum 12 months. We looked for studies that reported changes in clinical attachment levels (CAL), tooth loss, pocket probing depths (PPDs) and bleeding on probing (BoP) as outcome measures. RESULTS: Eight cohort studies were chosen for inclusion. There was considerable heterogeneity found between the eight studies, which did not allow for quantitative (meta) analysis and statistical testing of differences between groups. Clinical attachment levels remained relatively stable in patients who received specialist PM with mean changes of -0.42 mm to +0.2 mm, while for those enrolled in PDC-based PM for periods >12 months, mean CAL losses were between -0.13 mm and -2.80 mm. PPD reduction for those subjects receiving specialist PM was between 0.05 and 1.8 mm for five studies but two cohorts experienced increases of 0.32 and 0.80 mm, respectively. Increases of up to 2.90 mm (range: -0.1 to +2.90) and a higher proportion of deeper pockets were noted among PDC PM cohorts. Higher rates of BoP among those in receipt of PDC PM were reported in half of all studies. There were insufficient long-term data to make any firm conclusions about the effect of the delivery of PM on tooth loss. CONCLUSION: Within the limitations of the data available, it appears that specialist PM is effective in sustaining periodontal stability following active specialist intervention. There is limited evidence that PDC provides the same level of care; however, the limited comparative data available suggest that outcomes could be slightly worse in PDC. Copyright © 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. Publication Type Journal Article. Review. Year of Publication 2018 <127> Unique Identifier 28173609 Title The effect of tapered toothbrush filaments compared to end-rounded filaments on dental plaque, gingivitis and gingival abrasion: a systematic review and meta-analysis. [Review] Source International Journal of Dental Hygiene. 16(1):3-12, 2018 Feb. VI 1 Status MEDLINE Authors Hoogteijling F; Hennequin-Hoenderdos NL; Van der Weijden GA; Slot DE. Author NameID Hennequin-Hoenderdos, N L; ORCID: http://orcid.org/0000-0002-6740-5657 Slot, D E; ORCID: http://orcid.org/0000-0001-7234-0037 Authors Full Name Hoogteijling, Fcr; Hennequin-Hoenderdos, N L; Van der Weijden, G A; Slot, D E. Institution Hoogteijling, Fcr. Dental Hygienist practice Mondzorg Soest, Soest, The Netherlands. Hennequin-Hoenderdos, N L. Department of Periodontology, Academic Centre for Dentistry Amsterdam (ACTA), University of Amsterdam and Vrije Universiteit, Amsterdam, The Netherlands. Van der Weijden, G A. Department of Periodontology, Academic Centre for Dentistry Amsterdam (ACTA), University of Amsterdam and Vrije Universiteit, Amsterdam, The Netherlands. Slot, D E. Department of Periodontology, Academic Centre for Dentistry Amsterdam (ACTA), University of Amsterdam and Vrije Universiteit, Amsterdam, The Netherlands. Abstract AIM: This systematic review was performed to establish the effect of a manual toothbrush with tapered toothbrush filaments (TFTBs) compared to a manual toothbrush with end-rounded toothbrush filaments (ERTB) on clinical parameters of dental plaque, gingivitis and gingival abrasion. MATERIALS AND METHODS: MEDLINE-PubMed and Cochrane-CENTRAL databases were searched. The inclusion criteria were (randomized) controlled clinical trials, participants >=18 years and papers evaluating the effect of a TFTB compared to an ERTB. Data were extracted for dental plaque index (PI), bleeding scores (BS), gingival index scores (GI) and gingival abrasion scores (GA). A descriptive analysis and a meta-analysis were performed when appropriate. RESULTS: An independent screening of 33 unique papers resulted in seven eligible publications, which included eight comparisons. Meta-analysis did not show a significant difference between TFTB and ERTB with respect to PI scores. The meta-analysis of the GI scores showed a significant mean difference in favour of the TFTB (DiffM=-0.12 [95% CI: -0.17; -0.07]). Of the three comparisons evaluating GA, no differences were found. CONCLUSION: With respect to plaque removal, evidence that supports the recommendation for usage of a TFTB over an ERTB is lacking. Regarding GI, there is minimal evidence favouring a TFTB over an ERTB and the clinical relevance of this difference is probably negligible. Therefore, based on the collective evidence emerging from this systematic review, the strength and direction of the recommendation, there appears to be no firm evidence for a dental healthcare professional to advise the use of a TFTB over the use of an ERTB. Copyright © 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. Publication Type Comparative Study. Journal Article. Meta-Analysis. Review. Year of Publication 2018

<128> Unique Identifier 29565801 Title Mesenchymal Stem Cells of Dental Origin for Inducing Tissue Regeneration in Periodontitis: A Mini-Review. [Review] Source International Journal of Molecular Sciences. 19(4), 2018 Mar 22. VI 1 Status MEDLINE Authors Hernandez-Monjaraz B; Santiago-Osorio E; Monroy-Garcia A; Ledesma-Martinez E; Mendoza-Nunez VM. Authors Full Name Hernandez-Monjaraz, Beatriz; Santiago-Osorio, Edelmiro; Monroy-Garcia, Alberto; Ledesma-Martinez, Edgar; Mendoza-Nunez, Victor Manuel. Institution Hernandez-Monjaraz, Beatriz. Research Unit on Gerontology, FES Zaragoza, National Autonomous University of Mexico, 09230 Mexico City, Mexico. [email protected]. Santiago-Osorio, Edelmiro. Haematopoiesis and Leukaemia Laboratory, Research Unit on Cell Differentiation and Cancer, FES Zaragoza, National Autonomous University of Mexico, 09230 Mexico City, Mexico. [email protected]. Monroy-Garcia, Alberto. Immunology and Cancer Laboratory, Oncology Research Unit, Oncology Hospital, National Medical Center, IMSS, 09230 Mexico City, Mexico. [email protected]. Ledesma-Martinez, Edgar. Haematopoiesis and Leukaemia Laboratory, Research Unit on Cell Differentiation and Cancer, FES Zaragoza, National Autonomous University of Mexico, 09230 Mexico City, Mexico. [email protected]. Mendoza-Nunez, Victor Manuel. Research Unit on Gerontology, FES Zaragoza, National Autonomous University of Mexico, 09230 Mexico City, Mexico. [email protected]. Abstract Periodontitis is a chronic disease that begins with a period of inflammation of the supporting tissues of the teeth table and then progresses, destroying the tissues until loss of the teeth occurs. The restoration of the damaged dental support apparatus is an extremely complex process due to the regeneration of the cementum, the periodontal ligament, and the alveolar bone. Conventional treatment relies on synthetic materials that fill defects and replace lost dental tissue, but these approaches are not substitutes for a real regeneration of tissue. To address this, there are several approaches to tissue engineering for regenerative dentistry, among them, the use of stem cells. Mesenchymal stem cells (MSC) can be obtained from various sources of adult tissues, such as bone marrow, adipose tissue, skin, and tissues of the orofacial area. MSC of dental origin, such as those found in the bone marrow, have immunosuppressive and immunotolerant properties, multipotency, high proliferation rates, and the capacity for tissue repair. However, they are poorly used as sources of tissue for therapeutic purposes. Their accessibility makes them an attractive source of mesenchymal stem cells, so this review describes the field of dental stem cell research and proposes a potential mechanism involved in periodontal tissue regeneration induced by dental MSC. Publication Type Journal Article. Review. Year of Publication 2018 <129> Unique Identifier 29105764 Title Genetic polymorphisms and periodontal disease in populations of African descent: A review. [Review] Source Journal of Periodontal Research. 53(2):164-173, 2018 Apr. VI 1 Status MEDLINE Authors Goncalves PF; Harris TH; Elmariah T; Aukhil I; Wallace MR; Shaddox LM. Author NameID Shaddox, L M; ORCID: http://orcid.org/0000-0003-0948-1667 Authors Full Name Goncalves, P F; Harris, T H; Elmariah, T; Aukhil, I; Wallace, M R; Shaddox, L M. Institution Goncalves, P F. Department of Periodontology, College of Dentistry, University of Florida, Gainesville, FL, USA. Goncalves, P F. Department of Dentistry, Federal University of Jequitinhonha and Mucuri Valleys, Diamantina, MG, Brazil. Harris, T H. Department of Periodontology, College of Dentistry, University of Florida, Gainesville, FL, USA. Elmariah, T. Department of Periodontology, College of Dentistry, University of Florida, Gainesville, FL, USA. Aukhil, I. Department of Periodontology, College of Dentistry, University of Florida, Gainesville, FL, USA. Wallace, M R. Department of Molecular Genetics and Microbiology, College of Medicine, University of Florida, Gainesville, FL, USA. Wallace, M R. University of Florida Genetics Institute, University of Florida, Gainesville, FL, USA. Shaddox, L M. Department of Periodontology, College of Dentistry, University of Florida, Gainesville, FL, USA. Local Messages THIS JOURNAL IS AVAILABLE IN THE BDA LIBRARY, TO REQUEST THIS ARTICLE FROM THE LIBRARY GO TO: https://www.bda.org/library/journals-articles/Documents/photocopy-request-form.pdf Abstract Aggressive periodontitis is a rare but rapidly progressing form of periodontal disease that usually affects otherwise systemically healthy individuals, at a young age. It usually affects first molars and incisors, which are usually lost if treatment is not properly and

early rendered. Although of low prevalence, it affects individuals of African descent at a higher prevalence, and usually multiple members within the same family. Several studies have been performed in the attempt to evaluate specific single nucleotide polymorphisms (SNPs) that could be associated with this disease. To the best of our knowledge, the present article provides the first review of the literature focusing on studies that evaluated SNPs in patients of African descent with aggressive periodontitis. Several SNPs have been evaluated in different genes according to their role in the pathogenesis of the disease, with positive and negative associations (such as IL1, FCGR3B, FPR1, LTF, CYBA, GLT6D1, TLR4) with both the localized and generalized forms of aggressive periodontitis. Given the complexity of periodontitis, the difficulty in gathering large cohorts diagnosed with this rare form of disease, and the fact that candidate gene studies may only determine part of the genetic risk of a disease, the search for specific SNPs associated with aggressive periodontitis seems to be a long one, most likely to result in the combination of multiple SNPs, in multiple genes. Copyright © 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. Publication Type Journal Article. Review. Year of Publication 2018 <130> Unique Identifier 28990193 Title Antimicrobial peptides as a possible interlink between periodontal diseases and its risk factors: A systematic review. [Review] Source Journal of Periodontal Research. 53(2):145-155, 2018 Apr. VI 1 Status MEDLINE Authors Li S; Schmalz G; Schmidt J; Krause F; Haak R; Ziebolz D. Author NameID Ziebolz, D; ORCID: http://orcid.org/0000-0002-9810-2368 Authors Full Name Li, S; Schmalz, G; Schmidt, J; Krause, F; Haak, R; Ziebolz, D. Institution Li, S. Department of Cariology, Endodontology and Periodontology, University of Leipzig, Leipzig, Germany. Schmalz, G. Department of Cariology, Endodontology and Periodontology, University of Leipzig, Leipzig, Germany. Schmidt, J. Department of Cariology, Endodontology and Periodontology, University of Leipzig, Leipzig, Germany. Krause, F. Department of Cariology, Endodontology and Periodontology, University of Leipzig, Leipzig, Germany. Haak, R. Department of Cariology, Endodontology and Periodontology, University of Leipzig, Leipzig, Germany. Ziebolz, D. Department of Cariology, Endodontology and Periodontology, University of Leipzig, Leipzig, Germany. Local Messages THIS JOURNAL IS AVAILABLE IN THE BDA LIBRARY, TO REQUEST THIS ARTICLE FROM THE LIBRARY GO TO: https://www.bda.org/library/journals-articles/Documents/photocopy-request-form.pdf Abstract Antimicrobial peptides (AMPs) play a critical role in controlling innate and acquired immune responses. Local dysregulation of AMP is implicated in the pathogenesis of periodontal diseases as a response to periodontal pathogen challenge. Changes in AMP expression also characterize tobacco smoking, diabetes mellitus, obesity and rheumatoid arthritis, which are established risk factors of periodontal diseases, suggesting AMP may act as putative mechanistic links between these. The aim was to evaluate and summarize critically the current evidence pertaining to interrelationships between AMPs, periodontal diseases and selected periodontal disease risk factors. General and theme specific keywords were used to search the PUBMED database for studies relevant to AMP, periodontal diseases, smoking, diabetes mellitus, obesity and rheumatoid arthritis and critically reviewed. A total of 131 abstracts and 119 full text articles were screened for relevance; 13 studies were selected for inclusion after critical review. Local AMP dysregulation characteristic to periodontal diseases appears to occur within a broader landscape of complex systemic immune perturbations independently induced by smoking, metabolic and rheumatoid disease. The nature of these interactions and mechanistic pathways involved are inadequately understood. AMPs could be possible mechanistic interlinks between periodontal diseases and its risk factors. However, such evidence is very limited and more in vivo and in vitro studies are necessary to clarify the nature of such relationships. A greater understanding of AMPs as shared mediators is essential for unraveling their value as therapeutic or biomarker candidates. Copyright © 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. Publication Type Journal Article. Review. Year of Publication 2018 <131> Unique Identifier 28898418 Title Matrix metalloproteinase-8 levels in periodontal disease patients: A systematic review. [Review] Source Journal of Periodontal Research. 53(2):156-163, 2018 Apr. VI 1 Status MEDLINE

Authors de Morais EF; Pinheiro JC; Leite RB; Santos PPA; Barboza CAG; Freitas RA. Author NameID de Morais, E F; ORCID: http://orcid.org/0000-0002-2173-7672 Barboza, C A G; ORCID: http://orcid.org/0000-0003-1979-9919 Authors Full Name de Morais, E F; Pinheiro, J C; Leite, R B; Santos, P P A; Barboza, C A G; Freitas, R A. Institution de Morais, E F. Oral Pathology, Federal University of Rio Grande do Norte, Natal, Rio Grande do Norte, Brazil. Pinheiro, J C. Oral Pathology, Federal University of Rio Grande do Norte, Natal, Rio Grande do Norte, Brazil. Leite, R B. Oral Pathology, Federal University of Rio Grande do Norte, Natal, Rio Grande do Norte, Brazil. Santos, P P A. Oral Pathology, Federal University of Rio Grande do Norte, Natal, Rio Grande do Norte, Brazil. Barboza, C A G. Oral Pathology, Federal University of Rio Grande do Norte, Natal, Rio Grande do Norte, Brazil. Freitas, R A. Oral Pathology, Federal University of Rio Grande do Norte, Natal, Rio Grande do Norte, Brazil. Local Messages THIS JOURNAL IS AVAILABLE IN THE BDA LIBRARY, TO REQUEST THIS ARTICLE FROM THE LIBRARY GO TO: https://www.bda.org/library/journals-articles/Documents/photocopy-request-form.pdf Abstract Periodontal disease is characterized as a disorder of the oral microbiota resulting in an immune response which, in turn, leads to the destruction of periodontal tissue. Matrix metalloproteinase-8 (MMP-8) has been reported as the major metalloproteinase involved in periodontal disease, being present at high levels in gingival crevicular fluid and salivary fluid (SF). The aim of this systematic review was to evaluate the scientific literature regarding the expression of MMP-8 in gingival crevicular fluid and SF in patients with periodontal disease, analyzing its validity as a possible biomarker in the diagnosis of periodontal disease. A systematic review of the literature was performed using the PubMed/Medline, CENTRAL and Science Direct databases. Studies concerning the use of MMP-8 in the diagnosis of periodontal disease that evaluated its effectiveness as a biomarker for periodontal disease were selected. The search strategy provided a total of 6483 studies. After selection, six articles met all the inclusion criteria and were included in the present systematic review. The studies demonstrated significantly higher concentrations of MMP-8 in patients with periodontal disease compared with controls, as well as in patients presenting more advanced stages of periodontal disease. The findings on higher MMP-8 concentrations in patients with periodontal disease compared with controls imply the potential adjunctive use of MMP-8 in the diagnosis of periodontal disease. Copyright © 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. Publication Type Journal Article. Review. Year of Publication 2018 <132> Unique Identifier 29415708 Title IL-13 -1112 polymorphism and periodontitis susceptibility: a meta-analysis. Source BMC Oral Health. 18(1):21, 2018 02 07. VI 1 Status MEDLINE Authors Zhang W; Xu P; Chen Z; Cheng Y; Li X; Mao Q. Authors Full Name Zhang, Wenbo; Xu, Pu; Chen, Zhuogeng; Cheng, Yanan; Li, Xiaoni; Mao, Qiuhua. Institution Zhang, Wenbo. Department of Oral Implantation, Affiliated Haikou Hospital,Xiangya Medical School, Central South University, Hainan Provincial Stomatology Centre, Haikou, 570208, Hainan Province, China. Xu, Pu. Department of Oral Implantation, Affiliated Haikou Hospital,Xiangya Medical School, Central South University, Hainan Provincial Stomatology Centre, Haikou, 570208, Hainan Province, China. [email protected]. Chen, Zhuogeng. Department of Oral Implantation, Affiliated Haikou Hospital,Xiangya Medical School, Central South University, Hainan Provincial Stomatology Centre, Haikou, 570208, Hainan Province, China. Cheng, Yanan. Department of Oral Implantation, Affiliated Haikou Hospital,Xiangya Medical School, Central South University, Hainan Provincial Stomatology Centre, Haikou, 570208, Hainan Province, China. Li, Xiaoni. Department of Oral Implantation, Affiliated Haikou Hospital,Xiangya Medical School, Central South University, Hainan Provincial Stomatology Centre, Haikou, 570208, Hainan Province, China. Mao, Qiuhua. Department of Oral Implantation, Affiliated Haikou Hospital,Xiangya Medical School, Central South University, Hainan Provincial Stomatology Centre, Haikou, 570208, Hainan Province, China. Abstract BACKGROUND: Several studies have examined the association between the IL-13 -1112C/T polymorphism and the risk of periodontitis. However, these studies have reached different conclusions. The aim of the current study was to investigate the link between this IL-13 -1112 polymorphism and susceptibility to periodontitis. METHODS: We utilized electronic databases, including the CNKI (China National Knowledge Infrastructure), Wanfang, PubMed, Embase, and Cochrane Library databases, to manually search for relevant research published through November 30, 2016. The Chinese and English terms used to search the literature included "periodontitis", "periodontal disease", "IL 13", "IL-13", and "interleukin-13". In accordance with our inclusion criteria, we selected studies that involved case-control trials. All of these case-control trials described their objectives, design and specific statistical methods. For all included studies, odds ratios (ORs) and 95% confidence intervals (95% CIs) were provided or could be calculated from the study data. The quality of the included literature

was evaluated using the Newcastle-Ottawa scale (NOS). STATA 12.0 was used to calculate the sizes of the combined effects and conduct a sensitivity analysis of the results. RESULTS: Our meta-analysis included 4 articles representing 5 case-control studies with a total of 710 cases and 671 control subjects. The meta-analysis results indicated that the CC vs TT model, CT vs TT model and TT vs CT + CC model (CC VS TT: OR = 0.615, 95% CI = 0.395-0.957; CT vs TT: OR = 0.518, 95% CI = 0.323-0.830; and TT vs CT + CC: OR = 1.739, 95% CI = 1.130-2.676) were significant in five IL-13 -1112 gene polymorphism and periodontitis susceptibility models. Subgroup analysis indicated that the CC vs TT, CT vs TT and TT vs CT + CC models were significant in the chronic periodontitis (CP) group, whereas no significant differences were found in the five aggressive periodontitis (AgP) group models. The sensitivity analysis showed that dropping any single study did not affect the pooled analysis results. CONCLUSION: The IL-13 -1112 polymorphism may be associated with susceptibility to periodontitis. The IL-13 -1112 gene polymorphism may be associated with susceptibility to CP but not to AgP. Thus, large-scale, multi-ethnic case-control trials are still warranted. Publication Type Journal Article. Meta-Analysis. Research Support, Non-U.S. Gov't. Year of Publication 2018 <133> Unique Identifier 28282773 Title Association of periodontitis with preterm birth and low birth weight: a comprehensive review. [Review] Source Journal of Maternal-Fetal & Neonatal Medicine. 31(5):597-602, 2018 Mar. VI 1 Status MEDLINE Authors Puertas A; Magan-Fernandez A; Blanc V; Revelles L; O'Valle F; Pozo E; Leon R; Mesa F. Author NameID Puertas, Alberto; ORCID: http://orcid.org/0000-0001-5574-040X Authors Full Name Puertas, Alberto; Magan-Fernandez, Antonio; Blanc, Vanessa; Revelles, Laura; O'Valle, Francisco; Pozo, Elena; Leon, Ruben; Mesa, Francisco. Institution Puertas, Alberto. a Department of Obstetrics and Gynecology , "Virgen de las Nieves" University Hospital , Granada , Spain. Magan-Fernandez, Antonio. b Periodontology Department, School of Dentistry , University of Granada , Granada , Spain. Blanc, Vanessa. c Microbiology Laboratory, Dentaid Research Center , Barcelona , Spain. Revelles, Laura. a Department of Obstetrics and Gynecology , "Virgen de las Nieves" University Hospital , Granada , Spain. O'Valle, Francisco. d Pathology Department, School of Medicine , (IBIMER, CIBM) University of Granada , Granada , Spain. Pozo, Elena. b Periodontology Department, School of Dentistry , University of Granada , Granada , Spain. Leon, Ruben. c Microbiology Laboratory, Dentaid Research Center , Barcelona , Spain. Mesa, Francisco. b Periodontology Department, School of Dentistry , University of Granada , Granada , Spain. Abstract It is estimated that six million perinatal deaths occur every year worldwide, with premature birth being the main cause. Scientific evidence has shown that there is an association between periodontal health during pregnancy and adverse outcomes of labor, although interventional studies based on the treatment of periodontitis have failed to document an impact on reducing the incidence of preterm birth (PB) or low birth weight (LBW). Two pathogenic mechanisms have been proposed to explain this association. The direct pathway is based on the presence of gram-negative anaerobic bacteremia originating in the gingival biofilm, whereas the indirect pathway involves the production of pro-inflammatory markers which enter the bloodstream from the gingival submucosa. The result is the same: the development of an immune inflammatory response and/or the local suppression of growth factors in the fetal-placental unit, which in turn triggers labor. In the present review, we describe current concepts pertinent to PB and LBW, chronic and aggressive periodontitis, and the most frequent aspects of periodontal pathology during pregnancy. We evaluate the scientific evidence available to date, and offer a detailed description of the two pathways proposed to explain the association of maternal periodontitis with preterm and LBW delivery. Publication Type Journal Article. Review. Year of Publication 2018 <134> Unique Identifier 29502214 Title Does diabetes increase the risk of periodontitis? A systematic review and meta-regression analysis of longitudinal prospective studies. [Review] Source Acta Diabetologica. 55(7):653-667, 2018 Jul. VI 1 Status MEDLINE Authors Nascimento GG; Leite FRM; Vestergaard P; Scheutz F; Lopez R.

Authors Full Name Nascimento, Gustavo G; Leite, Fabio R M; Vestergaard, Peter; Scheutz, Flemming; Lopez, Rodrigo. Institution Nascimento, Gustavo G. Section of Periodontology, Department of Dentistry and Oral Health, Aarhus University, Vennelyst Boulevard 9, 8000, Aarhus C, Denmark. [email protected]. Leite, Fabio R M. Section of Periodontology, Department of Dentistry and Oral Health, Aarhus University, Vennelyst Boulevard 9, 8000, Aarhus C, Denmark. Vestergaard, Peter. Department of Clinical Medicine, Aalborg University Hospital, Aalborg, Denmark. Vestergaard, Peter. Department of Endocrinology, Aalborg University Hospital, Aalborg, Denmark. Vestergaard, Peter. Steno Diabetes Center, Aalborg University Hospital, Aalborg, Denmark. Scheutz, Flemming. Section of Periodontology, Department of Dentistry and Oral Health, Aarhus University, Vennelyst Boulevard 9, 8000, Aarhus C, Denmark. Lopez, Rodrigo. Section of Periodontology, Department of Dentistry and Oral Health, Aarhus University, Vennelyst Boulevard 9, 8000, Aarhus C, Denmark. Abstract AIM: Even though the association between diabetes and periodontitis is taken for granted, results on this association are conflicting within the literature. This systematic review assessed whether poorly controlled diabetes was associated with periodontitis onset or progression. METHODS: Electronic searches were performed in PubMed, Scopus and Embase databases. Hand search was carried out in the reference list of all articles included. Gray literature was investigated with a Google Scholar search. Prospective longitudinal studies on the association between diabetes and periodontitis were considered for this review. Studies should have presented at least two measurements of periodontal conditions over time. Data on study design, crude and adjusted estimates were collected. We used meta-analysis to estimate the pooled effect of hyperglycemia in people with diabetes on periodontitis onset or progression. Meta-regression and subgroup analyses were employed to investigate potential sources of heterogeneity between studies. RESULTS: Thirteen studies matched the inclusion criteria, comprising 49,262 individuals, including 3197 diagnosed with diabetes. Meta-analyses of adjusted estimates showed that diabetes increased the risk of incidence or progression of periodontitis by 86% (RR 1.86 [95% CI 1.3-2.8]). However, there is scarce information on the association between diabetes and periodontal destruction. CONCLUSIONS: This study provides evidence that diabetes is associated with increased risk of periodontitis onset and progression in adults. Upcoming prospective longitudinal studies ought to overcome methodological caveats identified in this review. Publication Type Journal Article. Meta-Analysis. Review. Year of Publication 2018 <135> Unique Identifier 29664916 Title Is periodontitis a risk indicator for cancer? A meta-analysis. Source PLoS ONE [Electronic Resource]. 13(4):e0195683, 2018. VI 1 Status MEDLINE Authors Corbella S; Veronesi P; Galimberti V; Weinstein R; Del Fabbro M; Francetti L. Author NameID Corbella, Stefano; ORCID: https://orcid.org/0000-0001-8428-8811 Authors Full Name Corbella, Stefano; Veronesi, Paolo; Galimberti, Viviana; Weinstein, Roberto; Del Fabbro, Massimo; Francetti, Luca. Institution Corbella, Stefano. IRCCS Istituto Ortopedico Galeazzi, Milan, Italy. Corbella, Stefano. Department of Biomedical, Surgical and Dental Sciences, Universita degli Studi di Milano, Milan, Italy. Veronesi, Paolo. European Institute of Oncology, Division of Senology, Milan, Italy. Veronesi, Paolo. Universita degli Studi di Milano, Milan, Italy. Galimberti, Viviana. European Institute of Oncology, Division of Senology, Milan, Italy. Weinstein, Roberto. Scientific Director D&S ICH Humanitas Dental Center, Rozzano, Milan, Italy. Del Fabbro, Massimo. IRCCS Istituto Ortopedico Galeazzi, Milan, Italy. Del Fabbro, Massimo. Department of Biomedical, Surgical and Dental Sciences, Universita degli Studi di Milano, Milan, Italy. Francetti, Luca. IRCCS Istituto Ortopedico Galeazzi, Milan, Italy. Francetti, Luca. Department of Biomedical, Surgical and Dental Sciences, Universita degli Studi di Milano, Milan, Italy. Abstract BACKGROUND: The aim of the present systematic review was to evaluate the hypothesis of an association between periodontitis and the development of cancer. METHODS: Two reviewers independently screened electronic and manual sources for pertinent articles. Primary outcome measures were the occurrence of neoplasm diagnosis in exposed and non-exposed groups, reported to evaluate association between cancer and periodontitis.

RESULTS: Of the 490 initially retrieved papers 10 were included in the qualitative synthesis and eight in the quantitative synthesis; the eight papers covered six studies. Considering hazard ratios, a statistically significant association was found for all cancers studied (1.14; CI 95%: 1.04, 1.24), digestive tract cancer (1.34; CI 95%: 1.05, 1.72), pancreatic cancer (1.74; CI 95%: 1.21, 2.52), prostate cancer (1.25; CI 95%: 1.04, 1.51), breast cancer (1.11; CI 95%: 1.00, 1.23), corpus uteri cancer (2.20; CI 95%: 1.16, 4.18), lung cancer (1.24; CI 95%: 1.06, 1.45), hematological cancer (1.30; CI 95%: 1.11, 1.53), esophagus / oropharyngeal cancer pooled together (2.25; CI 95%: 1.30, 3.90) and Non-Hodgkin lymphoma (1.30; CI 95%: 1.11, 1.52). CONCLUSIONS: Despite the sparse scientific evidence and considering the low statistical power of the results, this systematic review revealed a substantial lack of studies with standardized and comparable methods to speculate about the association between periodontitis and cancer; more studies are need in order to explore further the scientific evidence of such correlation. Publication Type Journal Article. Meta-Analysis. Year of Publication 2018 <136> Unique Identifier 29846383 Title Association between metabolic syndrome and periodontitis: a systematic review and meta-analysis. [Review] Source Pesquisa Odontologica Brasileira = Brazilian Oral Research. 32:e35, 2018 May 24. VI 1 Status MEDLINE Authors Daudt LD; Musskopf ML; Mendez M; Remonti LLR; Leitao CB; Gross JL; Weidlich P; Oppermann RV. Authors Full Name Daudt, Luciana Dondonis; Musskopf, Marta Liliana; Mendez, Marina; Remonti, Luciana Loss Reck; Leitao, Cristiane Bauermann; Gross, Jorge Luiz; Weidlich, Patricia; Oppermann, Rui Vicente. Institution Daudt, Luciana Dondonis. Universidade Federal do Rio Grande do Sul - UFRGS, Dental School, Department of Periodontology, Porto Alegre, RS, Brazil. Musskopf, Marta Liliana. Universidade Luterana do Brasil - Ulbra, Dental School, Porto Alegre, RS, Brazil. Mendez, Marina. Universidade Federal do Rio Grande do Sul - UFRGS, Dental School, Department of Periodontology, Porto Alegre, RS, Brazil. Remonti, Luciana Loss Reck. Universidade Federal do Rio Grande do Sul - UFRGS, Hospital de Clinicas de Porto Alegre, Division of Endocrinology, Porto Alegre, Brazil. Leitao, Cristiane Bauermann. Universidade Federal do Rio Grande do Sul - UFRGS, Hospital de Clinicas de Porto Alegre, Division of Endocrinology, Porto Alegre, Brazil. Gross, Jorge Luiz. Universidade Federal do Rio Grande do Sul - UFRGS, Hospital de Clinicas de Porto Alegre, Division of Endocrinology, Porto Alegre, Brazil. Weidlich, Patricia. Universidade Federal do Rio Grande do Sul - UFRGS, Dental School, Department of Periodontology, Porto Alegre, RS, Brazil. Oppermann, Rui Vicente. Universidade Federal do Rio Grande do Sul - UFRGS, Dental School, Department of Periodontology, Porto Alegre, RS, Brazil. Abstract The aim of the present study was to evaluate the association between metabolic syndrome (MS) and periodontitis (PD), through a systematic review and meta-analysis. Original observational studies assessing the association between MS and PD in adults, published before May 11th (2017), were identified through electronic searches of MEDLINE, EMBASE and Cochrane Library databases. The PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guideline was used. For studies to be included, they had to mention the criteria used to diagnose MS and to have used at least one clinical measure to diagnose PD. There was no language restriction. Three reviewers independently identified eligible studies for possible inclusion in the systematic review and meta-analysis. The quality of the studies was evaluated by the Newcastle-Ottawa scale for observational studies. A random model meta-analysis was conducted. The strategies used to investigate heterogeneity were sequential analysis, subgroup analysis, univariate meta-regression and sensitivity analysis. Thirty-three studies met the inclusion criteria for the systematic review, and 26 had enough information to be included in the meta-analysis, totaling 52,504 patients. MS and PD were associated with an odds ratio of 1.38 (95%CI 1.26-1.51; I2 = 92.7%; p < 0.001). Subgroup analysis showed that complete periodontal examination (I2 = 70.6%; p < 0.001) partially explained the variability between studies. The present findings suggest an association between MS and PD. Individuals with MS are 38% more likely to present PD than individuals without this condition. Prospective studies should be conducted to establish cause and effect relations between MS and PD. Publication Type Journal Article. Meta-Analysis. Review. Year of Publication 2018 <137> Unique Identifier 29374364 Title Effectiveness of laser adjunctive therapy for surgical treatment of gingival recession with flap graft techniques: a systematic review and meta-analysis. [Review] Source Lasers in Medical Science. 33(4):899-908, 2018 May. VI 1

Status MEDLINE Authors Yan J; Zhang J; Zhang Q; Zhang X; Ji K. Authors Full Name Yan, Jing; Zhang, Jie; Zhang, Qian; Zhang, Xinlu; Ji, Kui. Institution Yan, Jing. Department of Stomatology, The General Hospital of Tianjin Medical University, No. 154 Anshan Road, Heping District, Tianjin, 300050, China. Zhang, Jie. Department of Stomatology, The General Hospital of Tianjin Medical University, No. 154 Anshan Road, Heping District, Tianjin, 300050, China. [email protected]. Zhang, Qian. Department of Stomatology, The General Hospital of Tianjin Medical University, No. 154 Anshan Road, Heping District, Tianjin, 300050, China. Zhang, Xinlu. Department of Stomatology, The General Hospital of Tianjin Medical University, No. 154 Anshan Road, Heping District, Tianjin, 300050, China. Ji, Kui. Department of Stomatology, The General Hospital of Tianjin Medical University, No. 154 Anshan Road, Heping District, Tianjin, 300050, China. Abstract Various flap graft techniques in the treatment of gingival recession have already been reported in the literatures for root coverage. Laser therapy has effects of ablative, hemostatic, and decontamination. Therefore, we performed a meta-analysis of randomized controlled trials (RCTs) to compare the efficacy of flap surgery combined with laser with surgery alone for treating gingival recession. The studies were searched from PubMed, Embase, Web of science, and the Cochrane Central Register of Controlled Trials by two reviewers up to August 2017. The quality of RCTs was assessed by Cochrane Handbook. Data were extracted from studies and analyzed by Review Manager 5.3. 95% confidence interval (CI) and risk ratio (RR) were calculated for dichotomous data. Seven RCTs with 173 patients and 296 teeth were included in the meta-analysis. We found no statistically significant differences between two groups in GRD (gingival recession depth) (P=0.21), GRW (gingival recession width) (P=0.92), RES (root esthetic score) (P=0.21), and CRC (complete root coverage) (P=0.09). Statistically significant differences were found between two groups in the WKT (width of keratinized tissue) (P<0.0001) and 1-year follow-up of PD (probing depth) (P=0.03) and CAL (clinical attachment level) (P<0.00001). The meta-analysis found that surgery with laser therapy provided clinical advantages in terms of WKT and 1-year follow-up of PD and CAL. However, flap graft associated with laser did not offer additional benefit to root coverage and esthetics in treating gingival recession. More long-term studies are required to assess these parameters. Publication Type Journal Article. Meta-Analysis. Review. Year of Publication 2018 <138> Unique Identifier 29783069 Title Association between the rs1143634 polymorphism in interleukin-1B and chronic periodontitis: Results from a meta-analysis composed by 54 case/control studies. [Review] Source Gene. 668:97-106, 2018 Aug 20. VI 1 Status MEDLINE Authors da Silva FRP; Vasconcelos ACCG; de Carvalho Franca LF; Di Lenardo D; Nascimento HMS; Vasconcelos DFP. Authors Full Name da Silva, Felipe Rodolfo Pereira; Vasconcelos, Any Carolina Cardoso Guimaraes; de Carvalho Franca, Luiz Felipe; Di Lenardo, David; Nascimento, Helio Mateus Silva; Vasconcelos, Daniel Fernando Pereira. Institution da Silva, Felipe Rodolfo Pereira. Laboratory of Histological Analysis and Preparation (LAPHIS), Federal University of Piaui, Parnaiba, Piaui, Brazil; Post Graduation Program in Biomedical Sciences, Federal University of Piaui, Parnaiba, Piaui, Brazil. Vasconcelos, Any Carolina Cardoso Guimaraes. Medicine School, Education Institute of Parnaiba Valley (IESVAP), Parnaiba, PI, Brazil. de Carvalho Franca, Luiz Felipe. Laboratory of Histological Analysis and Preparation (LAPHIS), Federal University of Piaui, Parnaiba, Piaui, Brazil. Di Lenardo, David. Laboratory of Histological Analysis and Preparation (LAPHIS), Federal University of Piaui, Parnaiba, Piaui, Brazil. Nascimento, Helio Mateus Silva. Laboratory of Histological Analysis and Preparation (LAPHIS), Federal University of Piaui, Parnaiba, Piaui, Brazil. Vasconcelos, Daniel Fernando Pereira. Laboratory of Histological Analysis and Preparation (LAPHIS), Federal University of Piaui, Parnaiba, Piaui, Brazil; Post Graduation Program in Biomedical Sciences, Federal University of Piaui, Parnaiba, Piaui, Brazil; Post Graduation Program in Dentistry, Federal University of Piaui, Teresina, Piaui, Brazil. Electronic address: [email protected]. Abstract Several factors are involved in the periodontitis with host response through cytokines and as well as with influence of polymorphisms in cytokine genes, however the results remained contradictory. This study aimed at evaluating the rs1143634 polymorphism in interleukin-1B gene, a cytokine gene, and the risk of chronic periodontitis with conducting a meta-analysis focusing in ethnicity. A review in literature was performed in several databases to studies published before June 2017. Data extraction was performed by two calibrated investigators and the calculations of the meta-analysis were obtained through Review Manager version 5.2 statistical software with Odds Ratio (OR) calculation and Funnel plot (P<0.05) to heterogeneity and the Comprehensive Meta-analysis version 3.3.070 to assessment publication bias by Egger's and Begg's tests. In overall, 54

case/control studies composed the meta-analysis. T allele was significantly associated with patients case (OR=1.35, 95% CI: 1.24, 1.48, P<0.00001) in the overall analysis. The stratified evaluation showed the rs1143634 polymorphism had significant association with disease in Caucasian, Asian and mixed population was excepted in African ethnicity (P>0.05). No publication bias was found in allelic evaluation. This meta-analysis in 9376 participants with 54 case/control studies revealed the rs1143634 polymorphism was associated with elevated risk of chronic periodontitis in overall analysis as well as Caucasian and Asian ethnicities and Mixed population. Copyright © 2018 Elsevier B.V. All rights reserved. Publication Type Journal Article. Meta-Analysis. Review. Year of Publication 2018 <139> Unique Identifier 29568030 Title Periodontal disease has an impact on patients' quality of life. Source Evidence-Based Dentistry. 19(1):14-15, 2018 03 23. VI 1 Status MEDLINE Authors Reynolds I; Duane B. Authors Full Name Reynolds, Ian; Duane, Brett. Institution Reynolds, Ian. Dublin Dental University Hospital, Dublin, Eire. Duane, Brett. Dublin Dental University Hospital, Dublin, Eire. Comments Comment on: J Clin Periodontol. 2016 Apr;43(4):333-44; PMID: 26810308 Abstract Data sourcesMedline, Embase, OpenGrey, Journal of Clinical Periodontology, Journal of Periodontology and a hand search of the bibliographies of retrieved publications.Study selectionTwo reviewers screened the title and abstract of 1134 studies from the literature and selected 37 suitable publications for inclusion following full text analysis of 109 papers and agreement between both reviewers. The search included observational, epidemiological studies and clinical trials that fufilled the inclusion criteria. The publications assessed contained a periodontal clinical examination and a validated OHRQoL questionnaire. There were no language restrictions and the review was performed according to the MOOSE statement.Data extraction and synthesisData were extracted from each study applying the PECO format. The quality of the observational studies was evaluated by the Newcastle Ottawa Scale (NOS) and clinical trials by the (MINORS) methodological index for non-randomised studies. The Strength of Grading Taxonomy (SORT) was utilised to assess the level of evidence and strength of recommendation of the included studies. A meta-analysis was not undertaken due the heterogeneity of the included studies, therefore results were synthesised by applying a vote counting method.ResultsThirty-seven studies included in the review were evaluated by the vote counting method. According to NOS and MINORS the risk of bias was identified as moderate with most studies assessing 50% to 83% of the parameters established. A level two for quality of evidence and a level B for strength of recommendation were applicable for the relationship between clinically diagnosed periodontal disease and OHRQoL. The evidence level was consistent across the studies. Nineteen of the studies examined a distinct population group with respect to diagnosis of systemic disease, socioeconomic status, demographic background or periodontal diagnosis. Twenty-eight of the included studies reported an association between periodontal diseases and OHRQoL while eight of the publications highlighted a dose-response relationship between and extent and severity of periodontal disease and the impact on OHRQoL.ConclusionsThe findings support the association between clinically diagnosed periodontal diseases and subjectively assessed OHRQoL with a dose-response relationship demonstrated. In summation, periodontal diseases play a significant role in oral health and impact on the QoL of affected individuals. In publications that undertook a full mouth recording the results were more evident, therefore a comprehensive periodontal exam in conjunction with a validated OHRQoL questionnaire is recommended. Publication Type Journal Article. Comment. Year of Publication 2018 <140> Unique Identifier 29568020 Title Periodontal treatment for the prevention of adverse birth outcomes. Source Evidence-Based Dentistry. 19(1):12-13, 2018 03 23. VI 1 Status MEDLINE Authors Spivakovsky S. Authors Full Name Spivakovsky, Silvia. Institution

Spivakovsky, Silvia. New York University College of Dentistry, New York, USA. Comments Comment on: Cochrane Database Syst Rev. 2017 Jun 12;6:CD005297; PMID: 28605006 Abstract Data sourcesCochrane Oral Health and Pregnancy and Childbirth's Trial Registries, Cochrane Register of Controlled Trials, Cochrane Library, Medline Ovid, Embase Ovid and LILACS BIREME, clinicaltrials.com and the WHO Clinical Trials Registry Platform were searched for published and ongoing trials until October of 2016.Study selectionRandomised controlled trials (RCTs) investigating the effects of periodontal treatment in reducing or preventing perinatal and maternal morbidity and mortality with no exclusions of language or date of publication. Primary perinatal outcomes included: gestational age at birth, birth weight, small for gestational age and perinatal mortality, while the primary maternal outcomes included mortality, pre-eclampsia and treatment adverse effects.Data extraction and synthesisTwo authors independently screened for inclusion and extracted data. Risk of bias was assessed using the Cochrane 'risk of bias' tool.Dichotomous results were expressed as risk ratios (RR) with a 95% confidence interval (CI), and continuous data were expressed as mean differences (MD) with 95% confidence interval. Random-effects model was used for combining results.The quality of the evidence was assessed using GRADE.ResultsFifteen studies with a total of 7,161 participants met the inclusion criteria.Eleven studies (n = 5671) compared periodontal treatment with no treatment. For the outcome preterm birth before <37 weeks a calculated RR of 0.87, 95% CI 0.70-1.10 shows no clear difference. From seven studies (n = 3470) there is evidence that periodontal treatment may reduce birth weight <2500g (RR 0.77, 95% CI 0.48-0.95).There is unclear evidence on the effect of periodontal treatment on preterm birth <35 weeks, <32 weeks, perinatal mortality and pre-eclampsia.Three studies with 3,610 participants showed no evidence of difference in the outcome small for gestational age: RR 0.97, 95% CI 0.81-1.16.ConclusionsThere is no clear evidence that periodontal treatment during pregnancy has an effect on preterm birth. There is some evidence that it may reduce incidence of low birth weight.There is insufficient evidence to define what type of periodontal treatment is superior in preventing any adverse pregnancy outcome. Publication Type Journal Article. Comment. Year of Publication 2018 <141> Unique Identifier 29557404 Title Increasing prominence of implantology research: a chronological trend analysis of 100 top-cited articles in periodontal journals. Source European Journal of Oral Implantology. 11(1):97-110, 2018. VI 1 Status MEDLINE Authors Chiang HS; Huang RY; Weng PW; Mau LP; Su CC; Tsai YC; Wu YC; Chung CH; Shieh YS; Cheng WC. Authors Full Name Chiang, Ho-Sheng; Huang, Ren-Yeong; Weng, Pei-Wei; Mau, Lian-Ping; Su, Chi-Chun; Tsai, Yi-Wen Cathy; Wu, Yu-Chiao; Chung, Chi-Hsiang; Shieh, Yi-Shing; Cheng, Wan-Chien. Abstract PURPOSE: To identify 100 top-cited articles published in periodontal journals and analyse the research trends by using citation analysis. MATERIALS AND METHODS: 100 top-cited articles published in periodontal journals were retrieved by searching the database of the ISI Web of Science and Journal Citation reports. For each article, the following principal bibliometric parameters: authorship, geographic and institute origin, manuscript type, study design, scope of study, and citation count of each time period were analysed from 1965 to 2015. RESULTS: The identified 100 top-cited articles were retrieved from five periodontal journals and citation counts were recorded between 262 and 1,693 times. For the institute of origin, the most productive institute, in terms of the number of 100 top-cited articles published, was the University of Gothenburg (Sweden) (n = 19), followed by the Forsyth Dental Center (USA) (n = 15). Most manuscripts were original research (n = 74), and the inflammatory periodontal disease (n = 59) was the most frequent topic studied. Interestingly, the trend of increase average citation reached significance for implantology (beta = 26.75, P = 0.003) and systemic interactions (beta = 29.83, P = 0.005), but not for inflammatory disease (beta = -10.30, P = 0.248) and tissue regeneration (beta = 9.04, P = 0.081). By using multivariable linear regression in a generalised linear model, suitable published journal (Journal of Clinical Periodontology), geographic regions (Europe), more intense international collaboration, adequate manuscript type (review article) and study design (systematic review) could be attributed to escalating average citation counts in implantology (all P < 0.05). However, for systemic interactions, only geographic region and study design were significantly associated with the increasing citation trend. CONCLUSIONS: These principal bibliometric characteristics revealed escalated trends in average citation count in implantology throughout time. Conflict-of-interest statement The authors have stated explicitly that there are no conflicts of interest in connection with this article. The study was self-funded by the authors and their institution. Publication Type Journal Article. Year of Publication 2018 <142> Unique Identifier 29235165 Title

Melaleuca alternifolia and its application against dental plaque and periodontal diseases: A systematic review. [Review] Source Phytotherapy Research. 32(2):230-242, 2018 Feb. VI 1 Status MEDLINE Authors Casarin M; Pazinatto J; Santos RCV; Zanatta FB. Author NameID Casarin, Maisa; ORCID: http://orcid.org/0000-0002-3750-5091 Authors Full Name Casarin, Maisa; Pazinatto, Josiele; Santos, Roberto Christ Vianna; Zanatta, Fabricio Batistin. Institution Casarin, Maisa. Department of Stomatology, School of Dentistry, Federal University of Santa Maria, Santa Maria, Brazil. Pazinatto, Josiele. Department of Stomatology, School of Dentistry, Federal University of Santa Maria, Santa Maria, Brazil. Santos, Roberto Christ Vianna. Department of Microbiology and Parasitology, Universidade Federal de Santa Maria, Santa Maria, Brazil. Zanatta, Fabricio Batistin. Department of Stomatology, School of Dentistry, Federal University of Santa Maria, Santa Maria, Brazil. Abstract This is a systematic review of clinical and laboratory studies evaluating the effect of Melaleuca alternifolia on periodontopathogens, dental plaque, gingivitis, periodontitis, and inflammatory responses. The PubMed, Cochrane, Web of science, Bireme, Lilacs, Prospero, Open Grey, and Clinical Trials databases were searched to identify potentially eligible studies through October 2016. Of 1,654 potentially eligible studies, 25 were included in the systematic review. Their methodology was evaluated through the Cochrane Handbook for clinical studies and the GRADE system for in vivo/in vitro studies. Although clinical studies must be interpreted with caution due to methodological limitations, laboratory studies have found promising results. In vitro evidences showed that M. alternifolia has bactericidal and bacteriostatic effects against the most prevalent periodontopathogens. Clinical studies found comparable effects to chlorhexidine 0.12% in reducing gingival inflammation, although the antiplaque effect was lower. M. alternifolia also showed antioxidant properties, which are beneficial to the host, allied to the reduction on immune-inflammatory responses to pathogens. This systematic review suggests that the M. alternifolia has potential anti-inflammatory and antimicrobial properties, which can be easily applied to the periodontal tissues. However, further clinical trials are needed to elucidate the clinical relevance of its application. Copyright © 2017 John Wiley & Sons, Ltd. Publication Type Journal Article. Review. Year of Publication 2018 <143> Unique Identifier 29504999 Title Salivary matrix metalloproteinase (MMP)-8 as a biomarker for periodontitis: A PRISMA-compliant systematic review and meta-analysis. [Review] Source Medicine. 97(3):e9642, 2018 Jan. VI 1 Status MEDLINE Authors Zhang L; Li X; Yan H; Huang L. Authors Full Name Zhang, Lin; Li, Xiue; Yan, Hong; Huang, Lei. Institution Zhang, Lin. Department of VIP Dental Service. Li, Xiue. Department of Nursing, Peking University School and Hospital of Stomatology. Yan, Hong. Department of VIP Dental Service. Huang, Lei. Department of Clinical Laboratory, Peking University First Hospital, Beijing, China. Abstract BACKGROUND: Salivary matrix metalloproteinase (MMP)-8 is currently considered to be one of the most promising biomarkers for early diagnosis of periodontitis, however, several recent studies showed conflicting results. OBJECTIVE: To determine the salivary matrix metalloproteinase (MMP)-8 levels between periodontitis patients and healthy individuals, and to assess its diagnostic value in periodontitis. METHODS: Literatures were searched on PubMed and Embase databases up to August 2017, for articles reporting salivary MMP-8 levels between periodontitis patients and health controls with the data of means +/- standard deviation (SD). Methodological quality was assessed by the Newcastle Ottawa scale (NOS). Standard mean differences (SMDs), heterogeneity, and publication bias were assessed by Stata 13.0 software. RESULTS: A total of 10 studies including 485 periodontitis patients and 379 healthy controls that met the preset inclusion criteria were included, the qualities of these studies were either good (n = 7) or moderate (n = 3). Eight studies showed salivary MMP-8 levels were higher in periodontitis patients compared with healthy controls (P < .05), while 2 studies showed opposite results (P >

.05). The pooled SMD was 1.195 (95% CI: 0.720-1.670), with I of 89.3%, indicating high heterogeneity. Funnel plot showed publication bias existed. CONCLUSION: Our meta-analysis showed that salivary MMP-8 levels were significantly higher in periodontitis patients compared with healthy controls overall. Due to the heterogeneity and publication bias of included studies, further high quality studies are still needed to verify the conclusion. Copyright © 2017 The Authors. Published by Wolters Kluwer Health, Inc. All rights reserved. Publication Type Journal Article. Meta-Analysis. Review. Year of Publication 2018 <144> Unique Identifier 29291254 Title Supportive periodontal therapy (SPT) for maintaining the dentition in adults treated for periodontitis. [Review] Source Cochrane Database of Systematic Reviews. 1:CD009376, 2018 01 01. VI 1 Status MEDLINE Authors Manresa C; Sanz-Miralles EC; Twigg J; Bravo M. Authors Full Name Manresa, Carolina; Sanz-Miralles, Elena C; Twigg, Joshua; Bravo, Manuel. Institution Manresa, Carolina. Adult Comprehensive Dentistry, Dental School, University of Barcelona, Feixa LLarga s/n, Hospitalet de Llobregat, Barcelona, Spain, 08907. Abstract BACKGROUND: Periodontitis is a bacterially-induced, chronic inflammatory disease that destroys the connective tissues and bone that support teeth. Active periodontal treatment aims to reduce the inflammatory response, primarily through eradication of bacterial deposits. Following completion of treatment and arrest of inflammation, supportive periodontal therapy (SPT) is employed to reduce the probability of re-infection and progression of the disease; to maintain teeth without pain, excessive mobility or persistent infection in the long term, and to prevent related oral diseases.According to the American Academy of Periodontology, SPT should include all components of a typical dental recall examination, and importantly should also include periodontal re-evaluation and risk assessment, supragingival and subgingival removal of bacterial plaque and calculus, and re-treatment of any sites showing recurrent or persistent disease. While the first four points might be expected to form part of the routine examination appointment for periodontally healthy patients, the inclusion of thorough periodontal evaluation, risk assessment and subsequent treatment - normally including mechanical debridement of any plaque or calculus deposits - differentiates SPT from routine care.Success of SPT has been reported in a number of long-term, retrospective studies. This review aimed to assess the evidence available from randomised controlled trials (RCTs). OBJECTIVES: To determine the effects of supportive periodontal therapy (SPT) in the maintenance of the dentition of adults treated for periodontitis. SEARCH METHODS: Cochrane Oral Health's Information Specialist searched the following databases: Cochrane Oral Health's Trials Register (to 8 May 2017), the Cochrane Central Register of Controlled Trials (CENTRAL) (the Cochrane Library, 2017, Issue 5), MEDLINE Ovid (1946 to 8 May 2017), and Embase Ovid (1980 to 8 May 2017). The US National Institutes of Health Trials Registry (ClinicalTrials.gov) and the World Health Organization International Clinical Trials Registry Platform were searched for ongoing trials. No restrictions were placed on the language or date of publication when searching the electronic databases. SELECTION CRITERIA: Randomised controlled trials (RCTs) evaluating SPT versus monitoring only or alternative approaches to mechanical debridement; SPT alone versus SPT with adjunctive interventions; different approaches to or providers of SPT; and different time intervals for SPT delivery.We excluded split-mouth studies where we considered there could be a risk of contamination.Participants must have completed active periodontal therapy at least six months prior to randomisation and be enrolled in an SPT programme. Trials must have had a minimum follow-up period of 12 months. DATA COLLECTION AND ANALYSIS: Two review authors independently screened search results to identify studies for inclusion, assessed the risk of bias in included studies and extracted study data. When possible, we calculated mean differences (MDs) and 95% confidence intervals (CIs) for continuous variables. Two review authors assessed the quality of evidence for each comparison and outcome using GRADE criteria. MAIN RESULTS: We included four trials involving 307 participants aged 31 to 85 years, who had been previously treated for moderate to severe chronic periodontitis. Three studies compared adjuncts to mechanical debridement in SPT versus debridement only. The adjuncts were local antibiotics in two studies (one at high risk of bias and one at low risk) and photodynamic therapy in one study (at unclear risk of bias). One study at high risk of bias compared provision of SPT by a specialist versus general practitioner. We did not identify any RCTs evaluating the effects of SPT versus monitoring only, or of providing SPT at different time intervals, or that compared the effects of mechanical debridement using different approaches or technologies.No included trials measured our primary outcome 'tooth loss'; however, studies evaluated signs of inflammation and potential periodontal disease progression, including bleeding on probing (BoP), clinical attachment level (CAL) and probing pocket depth (PPD).There was no evidence of a difference between SPT delivered by a specialist versus a general practitioner for BoP or PPD at 12 months (very low-quality evidence). This study did not measure CAL or adverse events.Due to heterogeneous outcome reporting, it was not possible to combine data from the two studies comparing mechanical debridement with or without the use of adjunctive local

antibiotics. Both studies found no evidence of a difference between groups at 12 months (low to very low-quality evidence). There were no adverse events in either study.The use of adjunctive photodynamic therapy did not demonstrate evidence of benefit compared to mechanical debridement only (very low-quality evidence). Adverse events were not measured.The quality of the evidence is low to very low for these comparisons. Future research is likely to change the findings, therefore the results should be interpreted with caution. AUTHORS' CONCLUSIONS: Overall, there is insufficient evidence to determine the superiority of different protocols or adjunctive strategies to improve tooth maintenance during SPT. No trials evaluated SPT versus monitoring only. The evidence available for the comparisons evaluated is of low to very low quality, and hampered by dissimilarities in outcome reporting. More trials using uniform definitions and outcomes are required to address the objectives of this review. Publication Type Journal Article. Meta-Analysis. Research Support, Non-U.S. Gov't. Review. Year of Publication 2018 <145> Unique Identifier 29804165 Title Comment on "Efficacy of photodynamic therapy as adjunct treatment of chronic periodontitis: a systematic review and meta-analysis". Source Lasers in Medical Science. 33(6):1409, 2018 08. VI 1 Status MEDLINE Authors Capodiferro S. Author NameID Capodiferro, Saverio; ORCID: http://orcid.org/0000-0002-9819-6229 Authors Full Name Capodiferro, Saverio. Institution Capodiferro, Saverio. Department of Interdisciplinary Medicine, "Aldo Moro" University of Bari, Piazza G. Cesare 11, 70124, Bari, Italy. [email protected]. Comments Comment on: Lasers Med Sci. 2018 Feb;33(2):407-423; PMID: 29177555 Publication Type Letter. Comment. Year of Publication 2018 <146> Unique Identifier 29177555 Title Efficacy of photodynamic therapy as adjunct treatment of chronic periodontitis: a systematic review and meta-analysis. [Review] Source Lasers in Medical Science. 33(2):407-423, 2018 Feb. VI 1 Status MEDLINE Authors Azaripour A; Dittrich S; Van Noorden CJF; Willershausen B. Authors Full Name Azaripour, Adriano; Dittrich, Sebastian; Van Noorden, Cornelis J F; Willershausen, Brita. Institution Azaripour, Adriano. Department of Operative Dentistry and Periodontology, University Medical Center of the Johannes Gutenberg University Mainz, Augustusplatz 2, 55131, Mainz, Germany. [email protected]. Dittrich, Sebastian. Department of Operative Dentistry and Periodontology, University Medical Center of the Johannes Gutenberg University Mainz, Augustusplatz 2, 55131, Mainz, Germany. Van Noorden, Cornelis J F. Department of Cell Biology and Histology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands. Willershausen, Brita. Department of Operative Dentistry and Periodontology, University Medical Center of the Johannes Gutenberg University Mainz, Augustusplatz 2, 55131, Mainz, Germany. Comments Comment in: Lasers Med Sci. 2018 Aug;33(6):1409; PMID: 29804165 Abstract Meta-analysis of treatment effects of antimicrobial photodynamic therapy (aPDT) adjunct to non-surgical scaling and root planing (SRP) in comparison to SRP alone on patients with chronic periodontitis. The meta-analysis was performed according to PRISMA statement and Cochrane Collaboration guidelines. Electronic search complemented by hand search assured a high yield of randomized controlled trials (RCTs) of aPDT as adjunct modality to SRP. Differences in probing depth (PD) and clinical attachment level (CAL) were calculated with 95% confidence intervals and pooled in a random effects model. Analysis for intra- and inter-study heterogeneity was provided by chi 2 and I 2 tests, and publication bias was checked by funnel plots. Pooled overall effects of 26 RCTs attested significant benefits of aPDT adjunct to SRP with respect to PD reduction

(MD 0.37; 95% CI 0.12-0.53; P < 0.0001) and CAL gain (MD 0.33; 95% CI 0.19-0.48; P < 0.00001) after 3 and 6 months. Sensitivity analysis minimized heterogeneity of PD reduction (MD 0.21; 95% CI 0.13-0.30; P < 0.00001) and CAL gain (MD 0.36; 95% CI 0.27-0.46). aPDT adjunct to SRP provides significant PD reduction and CAL gain in treatment of chronic periodontitis. This moderate effect was found after 3 and 6 months which is short from a clinical perspective. Publication Type Journal Article. Meta-Analysis. Review. Year of Publication 2018 <147> Unique Identifier 29995795 Title A meta-analysis of emotional disorders as possible risk factors for chronic periodontitis. [Review] Source Medicine. 97(28):e11434, 2018 Jul. VI 1 Status MEDLINE Authors Liu F; Wen YF; Zhou Y; Lei G; Guo QY; Dang YH. Authors Full Name Liu, Fei; Wen, Yi-Feng; Zhou, Yuan; Lei, Gang; Guo, Qing-Yu; Dang, Yong-Hui. Institution Liu, Fei. Clinical Research Center of Shaanxi Province for Dental and Maxillofacial Diseases, College of Stomatology, Xi'an Jiaotong University. Liu, Fei. College of Medicine & Forensics, Xi'an Jiaotong University Health Science Center. Liu, Fei. Department of Pediatric Dentistry. Wen, Yi-Feng. Clinical Research Center of Shaanxi Province for Dental and Maxillofacial Diseases, College of Stomatology, Xi'an Jiaotong University. Wen, Yi-Feng. Department of Endodontic Dentistry, Affiliated Stomatology Hospita of Xi'an Jiaotong University. Zhou, Yuan. College of Public Health, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi, PR China. Lei, Gang. Clinical Research Center of Shaanxi Province for Dental and Maxillofacial Diseases, College of Stomatology, Xi'an Jiaotong University. Guo, Qing-Yu. Clinical Research Center of Shaanxi Province for Dental and Maxillofacial Diseases, College of Stomatology, Xi'an Jiaotong University. Guo, Qing-Yu. Department of Pediatric Dentistry. Dang, Yong-Hui. College of Medicine & Forensics, Xi'an Jiaotong University Health Science Center. Dang, Yong-Hui. State Key Laboratory for Manufacturing Systems Engineering. Abstract The aim of the present meta-analysis was to evaluate scientific evidence on the association between emotional disorder (depression and anxiety) and chronic periodontitis. An overall electronic literature search in PubMed, ISI Web of Science, Cochrane Library, and China National Knowledge Infrastructure was undertaken up to November 2017. Newcastle-Ottawa scale was applied to ascertain the validity of each eligible study. Stata statistical software was used to perform meta-analysis. The strength of the association between periodontitis and emotional disorder was measured by odds ratios (ORs) with their 95% confidence intervals (95% CIs). Subgroup analysis and sensitivity analysis were performed. Publication bias was assessed through funnel plots and Begger's test. A total of 14 eligible articles were included in the meta-analysis, 6 of them were focused exclusively on depression, whereas 8 studies investigated both depression and anxiety. There was significant association between emotional disorder and chronic periodontitis (OR = 1.54, 95% CI = 1.27-1.86). Sensitivity analyses confirmed the stability of the present results. No evidence of asymmetry was observed in Begger's test. This meta-analysis demonstrates significant association between emotional disorder (including anxiety and depression) and chronic periodontitis. Nevertheless, the result should be interpreted with caution because of the potential bias and confounding in the included studies. Publication Type Journal Article. Meta-Analysis. Review. Year of Publication 2018 <148> Unique Identifier 28869397 Title Precision of cone beam CT to assess periodontal bone defects: a systematic review and meta-analysis. [Review] Source Dento-Maxillo-Facial Radiology. 47(2):20170084, 2018 Feb. VI 1 Status MEDLINE Authors Haas LF; Zimmermann GS; De Luca Canto G; Flores-Mir C; Correa M. Authors Full Name Haas, Leticia Fernanda; Zimmermann, Glaucia Santos; De Luca Canto, G; Flores-Mir, Carlos; Correa, Marcio. Institution Haas, Leticia Fernanda. 1 Health Sciences Center, Federal University of Santa Catarina, Florianopolis, Brazil. Zimmermann, Glaucia Santos. 2 Department of Dentistry, Federal University of Santa Catarina, Santa Catarina, Brazil. De Luca Canto, G. 2 Department of Dentistry, Federal University of Santa Catarina, Santa Catarina, Brazil.

De Luca Canto, G. 3 Department of Dentistry, Faculty of Medicine and Dentistry University of Alberta, Edmonton, AB, Canada. Flores-Mir, Carlos. 3 Department of Dentistry, Faculty of Medicine and Dentistry University of Alberta, Edmonton, AB, Canada. Correa, Marcio. 2 Department of Dentistry, Federal University of Santa Catarina, Santa Catarina, Brazil. Local Messages THIS JOURNAL IS AVAILABLE IN THE BDA LIBRARY, TO REQUEST THIS ARTICLE FROM THE LIBRARY GO TO: https://www.bda.org/library/journals-articles/Documents/photocopy-request-form.pdf Abstract OBJECTIVES: Evaluate the diagnostic validity of CBCT in measuring periodontal bone defects when compared with the reference standard (in situ measurement). METHODS: Studies in which the main objective was to evaluate the diagnostic validity of CBCT in measuring periodontal bone defects when compared with the reference standard were selected. Four databases were searched. The studies were selected by two independent reviewers. The methodology of selected studies was assessed using the 14-item Quality Assessment Tool for Diagnostic Accuracy Studies. The quality of evidence and strength of recommendation was assessed by The Grading of Recommendations Assessment Tool, Development and Evaluation. RESULTS: Using a selection process in two phases, 16 studies were identified and, in seven articles meta-analysis was performed. The results from these meta-analyses showed that no difference between the measurements of CBCT and in situ for alveolar bone loss, and demonstrated a concordance of 82.82% between CBCT and in situ for the classification of the degree of furcation involvement. CONCLUSIONS: Based on a moderate level of evidence, CBCT could be useful for furcation involvement periodontal cases, but it should only be used in cases where clinical evaluation and conventional radiographic imaging do not provide the information necessary for an adequate diagnosis and proper periodontal treatment planning. Publication Type Journal Article. Meta-Analysis. Review. Year of Publication 2018 <149> Unique Identifier 29595680 Title Assessment of the periodontal health status in patients undergoing orthodontic treatment with fixed appliances and Invisalign system: A meta-analysis. Source Medicine. 97(13):e0248, 2018 Mar. VI 1 Status MEDLINE Authors Lu H; Tang H; Zhou T; Kang N. Authors Full Name Lu, Haili; Tang, Haifang; Zhou, Tian; Kang, Na. Institution Lu, Haili. Department of Orthodontics, the Affiliated Stomatological Hospital of Guangxi Medical University, Nanning, Guangxi, China. Abstract BACKGROUND: At present, many scholars have studied the periodontal health status of patients undergoing orthodontic treatment with fixed appliances and invisalign. However, those results are inconsistent. Therefore, we conducted this meta-analysis, and then provide reference for clinical treatment. METHODS: Most databases, such as the Cochrane Library, EMBASE, PubMed, Medline, Chinese Biomedical Literature Database, CNKI, and Wan Fang Data were retrieved for related articles from the establishment of the database to October 2017. Meanwhile, we also searched the references of the related literatures manually, in order to increase the included literatures. Two researchers screened the related literatures according to the inclusion criteria and exclusion criteria. Stata 12.0 software was used for data analysis, and results are estimated by odds ratio (OR) and 95% confidence interval (CI). RESULTS: Finally, 7 articles, including 368 patients, were included into our meta-analysis. Meta-analysis results showed that there was no statistically significant difference of gingival index (GI) and sulcus probing depth (SPD) status between the invisalign group and the control group, including at 1, 3, and 6 months (all P > .05). When compared with the control group, the invisalign group presented a lower plaque index (PLI) and sulcus bleeding index (SBI) status at 1 month (OR = -0.53, 95% CI: -0.89 to -0.18; OR = -0.44, 95% CI: -0.70 to -0.19, respectively), 3 months (OR = -0.69, 95% CI: -1.12 to -0.27; OR = -0.49, 95% CI: -0.93 to -0.05, respectively), and 6 months (OR = -0.91, 95% CI: -1.47 to -0.35; OR = -0.40, 95% CI: -0.63 to -0.07, respectively). Subgroup analysis showed that the SPD status was lower in the invisalign group at 6 months when measured the teeth using Ramfjord index (OR = -0.74, 95% CI: -1.35 to -0.12). However, there was no statistically significant difference between the 2 groups when using other measure methods (OR = 0.12, 95% CI: -0.26 to 0.17). CONCLUSION: Our meta-analysis suggests that comparing with the traditional fixed appliances, patients treated with invisalign have a better periodontal health. However, more studies are needed to confirm this conclusion in the future. Publication Type Journal Article. Meta-Analysis. Year of Publication 2018

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