BD Horizon Brilliant Violet Polymer ConjugatesThe complete portfolio of BD conjugated antibodies can...
Transcript of BD Horizon Brilliant Violet Polymer ConjugatesThe complete portfolio of BD conjugated antibodies can...
Helping nature to reveal itself.
BD Biosciences
2350 Qume DriveSan Jose, CA 95131bdbiosciences.com
For Research Use Only. Not for use in diagnostic or therapeutic procedures.BD, BD Logo and all other trademarks are property of Becton, Dickinson and Company. © 2013 BD23-14924-00
Now you can resolve rare or dim cell populations
with BD Horizon™ Brilliant Violet™ polymer
conjugates from BD Biosciences.
Developed from pioneering polymer dye
technology acquired from Sirigen Ltd.,
BD Horizon Brilliant Violet dyes are brighter
than conventional dyes. Improved brightness
enables you to identify cell populations
with lower receptor density than was
previously possible, resolving cell populations
previously obscured.
The complete portfolio of BD conjugated
antibodies can be used to explore cellular
features and characterize cells through surface,
intracellular, or secreted markers. To ensure you
can use BD reagents across your entire multicolor
panel, our portfolio contains a broad selection of
fluorochrome-conjugated antibodies.
Request a free sample, or find out how you
can use BD Horizon Brilliant Violet polymer
conjugates with our expanded set of tools and
information at bdbiosciences.com/go/brilliant.
BD Horizon™ Brilliant Violet™ Polymer ConjugatesBright dyes help resolve rare and dim cell populations
Stock up now on select cytokines, growth factors and chemokines.
cell sciences
®
cell ScienceS inc • 480 neponSet Street, Building 12A, cAnton, MA 02021 • [email protected]
toll free: (888) 769-1246 • tel: (781) 828-0610 • fAX: (781) 828-0542 • weB www.cellScienceS.coM
cytokine centerwww.cellsciences.com
®
Order any two vials from this list for just $235
Enter promo code CYT241 when you place your
order on-line or mention the promo code to get
your discount when calling our toll-free number
888-769-1246.
These recombinant proteins are low endotoxin,
carrier-free, highly pure, biologically active and
suitable for cell culture and animal studies. Get
two of the same item or pick any two different
items from the list.* See our web site for com-
plete product specifications.
Browse our web site of recombinant proteins,
including hundreds more cytokines, growth
factors, chemokines and neurotrophins. Bulk
quantities of these proteins are available at
competitive pricing. Call or visit our web site for
details. Cell Sciences also carries correspond-
ing antibodies and ELISA kits.
* Good on orders in US and Canada only. This offer may not be com
bined with other offers or discounts. All products for research use only.
Catalog No: Item: Size:
CRB100B Recombinant Human BMP-2 10 μg
CRC400B Recombinant Human CNTF 20 μg
CRF000B Recombinant Human FGF-acidic/FGF1 50 μg
CRF001B Recombinant Human FGF-basic/FGF2 50 μg
CRK300B Recombinant Human FGF-7/KGF 10 μg
CRG300B Recombinant Human G-CSF/CSF3 10 μg
CRG100B Recombinant Human GM-CSF/CSF2 20 μg
CRG101B Recombinant Mouse GM-CSF/CSF2 20 μg
CRG500B Recombinant Human GRO-alpha/cXcl1 25 μg
CRG502B Recombinant Rat GRO-alpha/KC/cXcl1 25 μg
CRI004B Recombinant Human IFN-alpha 2b 100 μg
CRI000B Recombinant Human IFN-gamma 100 μg
CRI001B Recombinant Mouse IFN-gamma 100 μg
CRI002B Recombinant Rat IFN-gamma 100 μg
CRI500B Recombinant Human IGF-1 100 μg
CRI100B Recombinant Human IL-2 50 μg
CRI153B Recombinant Human IL-10 10 μg
CRI137B Recombinant Human IL-15 10 μg
CRI162B Recombinant Human IL-17 25 μg
CRI172B Recombinant Human IL-21 10 μg
CRI225B Recombinant Human IL-33 10 μg
CRM151B Recombinant Human M-CSF/CSF1 10 μg
CRR000B Recombinant Human RANTES/CCL5 20 μg
CRS000B Recombinant Human SDF-1 alpha 10 μg
CRS002B Recombinant Human SDF-1 beta 10 μg
CRT100B Recombinant Human TNF-alpha 50 μg
CRT192B Recombinant Mouse TNF-alpha 20 μg
CRV000B Recombinant Human VEGF 165 10 μg
CRV014B Recombinant Mouse VEGF 165 10 μg
Buy one, get one free
Cut smarter.Restriction enzymes from NEB –
now with CutSmart™ Buffer
You make smart choices every day. Why stop there? The choice to use
restriction enzymes from New England Biolabs is now even easier.
• Choose from > 200 restriction enzymes supplied with a single buffer
• Simplify your double digest reactions
• Reduce your pipetting steps by no longer having to add BSA
Now, that’s Smart!
✁
Explore the smarter choice at
NEBCutSmart.com
For life science research only.
Not for use in diagnostic procedures.
X-TREMEGENE is a trademark of Roche.
Roche Diagnostics GmbH
Sandhofer Straße 116
68305 Mannheim, Germany
© 2013 Roche Diagnostics.
All rights reserved.
Demanding Transfection. Easy Solution.
Focus your efforts on discovery. Efficiently transfect difficult cells, including more than
100 cancer cell lines using X-tremeGENE DNA Transfection Reagents.
Free sample and protocols at
www.x-tremegene.roche.com
The Brain Prize recognizes and rewards outstanding contributions to European neuroscience, from basic to clinical
Grete Lundbeck European Brain Research Foundation
Call for Nominations for
THE PRIZEOF€ 1MILLIONWILL BE AWARDED INCOPENHAGEN 1MAY 2014
Nominations by 15 September 2013
Nominations will be reviewed by the Selection Committee:
YVESAGID, FRANCE
HUDAAKIL,USA
ANDERS BJÖRKLUND, SWEDEN, VICE-CHAIRMAN
COLIN BLAKEMORE,UNITED KINGDOM, CHAIRMAN
FREDH. GAGE,USA
FLORIANHOLSBOER,GERMANY
RANGAR. KRISHNAN, SINGAPORE
JESOLESEN,DENMARK
FOR THENOMINATION FORMANDDETAILSOF THENOMINATION PROCEDURE, PLEASE VISIT:
WWW.THEBRAINPRIZE.ORG
THEBRAINPR1ZE
PrizeWinners 2013
Ernst Bamberg,MPIBP, Frankfurt amMain, Germany, Ed Boyden,MIT, Cambridge,MA, USA,
Karl Deisseroth, StanfordUniversity, CA, USA, PeterHegemann, Humboldt University, Berlin, Germany,
GeroMiesenböck, University of Oxford, UnitedKingdom andGeorgNagel, University ofWürzburg, Germany
*AAAS follows CAN-SPAM and European Safe Harbor guidelines for protecting your privacy. We will never sell your e-mail address and you can opt-out of receiving e-mails at any time.
Are you currently registered to receive e-mails from AAAS and Science?
E-mail is the primary way that AAAS communicates with our members
about AAAS programs, new member benefits, invitations to special
events, and, of course, the latest news and research being published
in Science.
Sign up today to receive e-mails from AAAS and ensure that you are
getting the most out of your membership and Science subscription.*
To get started visit: promo.aaas.org/stayconnected
You’ll need your AAAS Member number. Find it above your name on
your Sciencemailing label.
Don’t miss a thing. Sign up for e-mail communications from AAAS today!
Get more from your AAAS membershipGet more from your AAAS membbeerrsshhiipp
STAY INFORMED!
STAY CONNECTED!
Eppendorf®, the Eppendorf logo and Eppendorf ThermoTop® are registered Trademarks of Eppendorf AG, Germany.
Eppendorf ThermoMixer™, Eppendorf SmartBlocks™, Eppendorf ThermoStat™ and Eppendorf QuickRelease™ are Trademarks of Eppendorf AG.
All rights reserved, including images and graphics. Copyright © 2013 by Eppendorf AG.
Eppendorf ThermoMixer™ and Eppendorf ThermoStat™
The new generation of Eppendorf Tem-
perature Control and Mixing Instruments
ofer you more than what meets the eye.
Not only do they provide the versatility
and accurate temperature control you
come to expect, they now also ofer you
superior mixing performance, outstand-
ing ergonomic operation and a unique
ThermoTop.
> 2DMix-Control: perfect mixing results
in all vessel formats
> Eppendorf QuickRelease™: ergonomic
block exchange in just 2 seconds
> Intuitive operation: pre-optimized
program and temperature keys
> Eppendorf ThermoTop prevents
condensate formation for more
accurate results.
www.eppendorf.com/thermomixer-c
New accessory:
Eppendorf
ThermoTop®
Multiple Talents
Learn more at: www.eppendorf.com/prize
2012 Winner
Dr. Marlene R. Cohen
Assistant Professor
University of Pittsburgh
Eppendorf & Science Prize for Neurobiology
The annual Eppendorf & Science Prize for Neurobiology,
an international award, honors young scientists for their
outstanding contributions to neurobiological research.
The winner and finalists are selected by a committee
of independent scientists, chaired by Science’s Senior
Editor, Dr. Peter Stern. To be eligible, you must be 35
years of age or younger.
You could be next to win this prize and to receive
> Prize money of US$25,000
> Publication of your work in Science
> Full support to attend the Prize Ceremony held in
conjunction with the Annual Meeting of the Society for
Neuroscience in the USA
> An invitation to visit Eppendorf in Hamburg, Germany
It’s easy to apply!
Call for EntriesApplication Deadline
June 15, 2013
883
����������������������������� ������������������ ����������
���������������� � ����
www.sciencemag.org/products SCIENCE VOL 340 17 MAY 2013
����*�����������)��������)����,�)���+�,) ��)���+�,�����)�+�, +� �+!��,)����) �����)+� ��+���+ ) �,) ��"�#�) ���) +� �+!��,$) +��,!�+�$) ��) �+,���) ,�) , ������)���� )�,+)���+��)����)�����+�)��) ���)����)� ����, %)���)��)���+�,)����) )�) �+����+��$)����)�,� ,����+��) +,����)������)�,+)�+�,���) +� �+!��,)��) �,+���),�) ����+�)����)�� %)�����)�,� ,����+��)� �+� )���)����) )�+��),�)��)����),+)����),����) �,� ,�� ) �,)���!�+) �����+) �� ��) ���+��) ��) ��� �������%)&� ���) ��������)�,+) ���)����)� ����, $)���+�,�����)����� )����)+��,!�+�)��) , ������)�+,���),�) ��+ ,���) ���)���� )��)��+��) +,���,+)���� %)���) �+����+��)�,+�����,)���� )�����+����,) ,�����) ��) ��#� ) ,���,� ) ����+����,) ,�) ���)���� %)���+�,)��)���+�,�����)�+�)�� ���)�,)�� ��)���+���)�,) �) +� ��+���+' ) �" ��) ����) �����+�)�,+(��,�) ��) +,�� � %)��� ��+���+ )��) � ��)���)���)���+�,)�+�, +� �+!��,)����)�+�����)�,) +� �+��)���� )��)�+� ��+)�,)�)���+�,)������)���)�+�,!��)�,+) �� ��)���+��)��+�)�+��#�)��)�,����+�) �,+���%)�� �������� �����������
������������������222���"���4�5� ��4"�5�
����������2��#��2(��2���2 ����� �2������422���2)����2�����!2���2*"+2,�2-�3��2�5���2�����4 2��� �4����2�����42��4�54����2���2�5���5��2�����2�545� 2����2 52-�3��2 �.�����"2���2 )����2 �54�� ����2 �����25�2 ����� 2 �5�42 ��4����2 � !2 �45�2 *"+2 �52 /2 ,�!2 �45���2 ����4��52 5���5 2 �542 �4������2 ���4�2 ��45���5�4����2 �������52 ��2�� �2����5�2�4� ��4�����2�45�2-�3��2�52�3��2�52�4���4����� ����2��"2(��2�������2����� 25��420''!'''2����� 2��42����4!2���2)����2*"+2,�24��4� �� 2 �2 �4�����2 ���������2 2��2����2 ����5�5��"2-�3��2� �4 2��25�24����2�4��5� ��2���������2����� 25�2 � ����2��2��4�54����!2���2���2�����2�����25�2�� �2����5�2�4� ��4�����2��2 ��������2 �52��25�2 ���2 ��4��25���42)����2��4����2 � "2(���2�����2 �545� 2 ���12 ,�2 �5��� 2 �����2 �����2 ���2 22�45����2���2 �52 �4��5��2 �����2 � 2 ��5�2 4���2 �4�� � !2 ���2 )����2 ��4����2�54��5�5��2 ��2 ���$�2 ����5�5��2 ����2 �52 4�����2 ��� �2 ��2 5����42 ������ 2 �52 � �4�2 ���2 4� 5���52 ��2 � ����2 5��42 �2 �������2���42���5���"2����������
%542�5&2+*'�1*1�'///222222���"���5����"�5�
Electronically submit your new product description or product literature information! Go to www.sciencemag.org/products/newproducts.dtl for more information.
Newly offered instrumentation, apparatus, and laboratory materials of interest to researchers in all disciplines in academic, industrial, and governmental organizations are
featured in this space. Emphasis is given to purpose, chief characteristics, and availability of products and materials. Endorsement by Science or AAAS of any products or
materials mentioned is not implied. Additional information may be obtained from the manufacturer or supplier.
&�", ���, '��'��,%���+/���������.,%��,�����,������,������/,�/,�����.�,�����,,&�"!,��������,,����� ,��� , ��, *)�����, �/���.��/� , ���, $��, ������,������, �.��.� , �/�����, ������������ ,��,��/��������-�,�/���/,,(������,��,�/�����,���./�.���,�/.,���,$�#�,���!,��/��������-�,�/���/,�����.�,������,�/��.�����,�/,�����!,���,������,�.��.,����,����,/,�/�,/�,���,���������,���,��������,���,�����,�/,�.����,�,&�",��./���!,'��,���,+/���������.,%��,�,��,����,��,��.�/.��,�����.�,*�",����,�����.�,�����,��,�./������/!, ����.�,�����,,&�",���������,.���,�/.���/,/�,��/���,���,�/�����,�����/����$�,��.����.��,���,���������,��.���/� ,����,�./���,�,�/.�,����.���,.��.������/,/�,�����,����/����,,��/!,���,�./����,�,�/�������,���,�.������,��,����,���� ,�����,�.��.�,��,����,����� ,���,��,����,���� ,���,�����.�,�����.�,�./�/�/��,��,����/���,����(��� ,��,�,���������,�/,���/,������,��,�����,����.�!,������
� ����� ������������777���$�� �$�:�
3���������7���8��7���%78/������7���7 �� �8���7 �������7 �:9' ���:7 7 ���7 �9 �7 �����7 ���:�����7 �� ���7 ���9���7 �����7 ��9�7 �����7 ��7 �0��7 �����7 �:7 :�7�� �7 �:9'��:�$7���7 �� �8���7 �������7 � ���7 ����� ��7 ���9��� 7�����7:�7��7��������9�7-�����7(����7��7%�8.7 �����7�:������:7��9� 7���7 ���:�����7 �����7�!�9���:#7 ������7 �:��:7�:������' 77���:9��:9�7�9:�� � $7���7 � ���7��"� 7����7�99:97��7����� 7���7��9:������7 �����7�9���9��:7�:97�7 �9���7:�7��������: #7 ���7 � 7 �:9� �7 9���9���7 ������ �#7 �9������7 ��7 �����7�9��7�����:� �7��7���9���:'��� 75%�8.67 ���� #7��7�:!�:�:���7 ���� $7���7�� �8���7�:9' ���:7 7�� ��7:7���7�����:7�:�:��� 7��9:���7�������7�����:9�7��7�����9� 7��:7 �����7�:���� 7��79:�:��7�9� 7�:97�9� �:9��7��7�����7����97��9� $7���7 ����� 7�9�7�:�:9��7��7�:��9���7�9��'�7 :����9�7�:7������7��7�����7:�7 �����7�������:7�99:9 $7���7��9�7�9:�� 7 7�9��'��7� �7�����79��:��:$7�����:& 7�9:�9���9�7 :����9�#7�� ��7:7�� �9��7�����7 :7����:�:��#7�9: �� 7�:������7�:�9:�7��7�:�:9�7:�7���7�����7�9:�� $7���������������
(:97�:)7*++�,2*�141+ ���"�����767�7���"�7�
5������4�4����0�#�45,�4�%� �����40��#�����4567��4�40����4�6�4������4�764���4��6����747�4�77��7��4��4�7����7��4���7���4�67�4�46���47�4���6��4�7�6���"4�����4��6��������4 �����4�����47���64 �4 �7����4����7�4 �764 ������4���4��6��4��4���46��7��6�47�4 ���7��7����4 1���24 �67�4����4 �����6�!4������!4 ��4 ��6��4�������"4����4���4���74��4����4 �764���4 ��67�������4���7��4��6����734���7��4��6����74��4�7���6��74�67�4�������7����4764�����4 �7�6��4����6��34 ��4 �764 ���7��7���4�������7"4����4567��4�40����4�6�4�7��7���47�4674�����������4��4���67�767��4 ������7��!4����4 6������4 4 �7�4 7������4 ���4 ��4����-�����4��6����7"4�7���4���������4������6�4�4����4�74��7��� �46��7����4567��4�4�67��4�7�������4���44���4����476�����7474���4����$�4��6����"4���476����747�4���������4��67���4���4����7����47�4���4 ��7�� ��4�67���"4���4�����$4�����4������4�67��6���4���7�4����47�4�����4��4����4��46���4��4������4�67��4�����6�!4��4��4��4����4���4�4��6���47�4������4�����"4��������
%764�7&4*('�/).�.++(444444���"�67����"�7������
Support thesciences.Get rewarded.Show your AAAS pride and reward
yourself with the new AAAS
Platinum Advantage Rewards Card
from NASA Federal Credit Union.
Apply now and get
10,000 bonus points!
Go to nasafcu.com/AAASpromo
Get 10,000 bonus
points if you sign up
for a card and spend
$3,000 within 90 days
of account opening.
Learn more at
nasafcu.com/AAASpromo.
Subject to credit approval.
Membership in AAAS and NASA FCU is required.
NASA FCU is federally insured by NCUA.
It’s time to rethink what you know about real-time PCR. At the heart of our real-timePCR detection systems is a commitment to giving you the best results possible—quicklyand easily. Our real-time PCR supermixes and new PrimePCR assays work togetherwith our systems to deliver superior results every time. Enjoy a new degree of usability,quality and peace of mind that will launch your research forward.
Find out more at bio-rad.com/ad/rtpcr3
CFX96 TOUCHª REAL-TIME
PCR DETECTION SYSTEM
BE ASTONISHEDBY THE RESULTS OF OUR
REAL-TIME PCR.(YOU’LL NEVER NEED TO COMPROMISE AGAIN.)