BBMRI - Biobanks, an under-used resource
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Transcript of BBMRI - Biobanks, an under-used resource
Biobanks, an under-used resourceMark Divers
Karolinska Institutet Biobank och BBMRI.se
Vinnova-VR workshop , Stockholm, juni 2012
Forskningsinfrastruktur för industriella innovationer
But biobanking is hot!
• Big interest• >$1B technology spend per year
• Big population studies appeared• Hunt, deCode, UK Biobank, LifeGene, LifeLines, Kadoorie
• Big analysis transformation• Genetic and protein technologies
• Big discussion• Many hopes, many fears
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Growing impact on medical research Huge public health opportunity
What is a biobank?
• Organiserad collection of biological samples– Often human
• Archived long-term– Frozen: -20, -80, -190°C
• Searchable & accessible– Samples and data
• Used for research, development and healthcare– Described as gold-mine!
• Regulated by law
Biobank landscape of Sweden
• 579 Biobanks
Biobank landscape of Sweden – for healthcare
Tissue 114 M sampelsCells 28, 7 MBlood/plasma 4530000Serum 2200000DNA/RNA 69000Bone 110000Others 106000
Biobank landscape of Sweden – for research
Blood/Plasma 4,2 MSerum 2,3 MDNA/RNA 572000Tissue 51000Urin 230000Salivia 112000Other 47000
The biobanks of KI and BBMRI.se are a rich source of samples: 150 studies
Population cohorts• TwinGene, LifeGene,
EpiHealth• Karma, Stockhom-2Disease based studies• Cancer• CV• Neurological• Inflammatory• ImmunologicalQuality registers
A good climate for biobank-based research in Sweden
• Well-characterised population• personal number system
• systematic registries
• Track-record• Eg Swedish Twin Registry ”TwinGene”
• Large population cohorts emerged 2009• LifeGene, EpiHealth
• Long-term research impact
• Public support
But challenges too
• Fragmentation• Organisational• Logistic• Economic
• Complex ethico-legal landscape
EU BBMRI initiative: our chance to create biobanks of the future
• Technology: test and apply the best!
• Network: connect modern biobanks!
• Vision: 300 biobanks throughout EU
• Harmonise: evolve common standards!
• Add big public health value!
Swedish Science Research Council and KI fund BBMRI.se for 5 years
large-Scale Swedish Biobanking (SSB); a service for big national studies
Some biobank accounts May 2012Total KIBB BBMRI.se
# studies 150 140 10# samples 2 634 210 584 578 2 049 632# donors 233 950 153 201 80 749# DNA samples 197 519 138 963 58 556# withdrawals >225 000 >175 000 >50 000
Creating a BBMRI.se national network
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Progressive build up in medical universities
• Goteborg node
• launch Jan 2012
• 1st project: Scapis
• Malmö node
• launch 1Q2012
• 1st projects: EpiHealth, MKC, MFM
• Linköping, Umeå, Uppsala to come
• Linköping launch 1H2013?
• Projects identified
Starting co-ordination with healthcare biobanking
Co-ordinated:• Sample format• Data format• Processes• Equipment & consumables• Access and use
Unifying Swedish biobanks further
University + Healthcare biobanks• National common infrastructure
– VR - SKL declaration
• Regional partnerships, eg– Uppsala biobank– Göteborg– Region Skåne– KI – SLL
Why are we biobanking?...
… to advance medical research!
• Combine with modern bio-analysis• Systematic• Statistical power
• Huge potential for public health
Study publications
GALLSTEN 4
PAIN 2
BAMSE 8
SCALE 15
Ekonomiskt beteende 2
TwinGene & Euroclot 13
HARMONY & SATSA 12
KTS 1
CAPS 40
Totalt 97
Emerging highlights
• Multiple Sclerosis
• TwinGene
• Broad
• Influenza Like Illnesses
• Prostate Cancer
What is the value of biobanking?...
Multiple Sclerosis research gives a great example*
• ~17K MS cases in Sweden• Many represented in our biobank• New therapy, Tysabri™
• Monoclonal antibody• Very effective, very expensive• Serious side effects in some (polyoma viral cross-reacton)
• Screen MS biobank for polyoma virus• Save big drug cost (200KKr/patient/yr)• Save some lives, improve others• Match a good drug to the right patients http://www.pharmatimes.com/Article/12-01-23/New_Tysabri_label_to_personalise_treatment.aspx
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*T Olsson et al
Biobanking adds big valueClinical practice
Health economy
Drug development
Ethical credibility
Sample collection
Sample analysis
Data analysis
Better screening, diagnosis and treatment match
Better public health for lower cost
Increased trust and support
Matching patients to treatmentsEthical review
eg HPV, MS
eg MS, HIV, HPV
eg HPV
2012-01-03 Mark Divers
Biobanks for industrial innovation?
Discovery & Development• Pharmaceuticals
– Biomarkers– Patient subtyping– Metabolites– Safety profiling
• Diagnostics• …
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Lab OperationsCarita RaskJaspal Singh
Cecilia AgardhPeter ArnerlövAnci CarmanPia Hillelson
Camilla LagerbergVian OsmanAmina Said
Anette SelanderJohanna Smith
Siwonne AnderssonEmma RidellWilliam Day
Valentina NovakKarin Lindqvist
Biobank ITEva Büren
Staffan BerghJonas Birgersson
Ulrika BohlinJesper Lind
Johan StenningerJosé Tapia
Anni ÅsbergNiclas Ahlin
Project coordinationAnders Brinne
Biobank DevelopmentGunnel Tybring
QualityAnette Petersson
Mirja Larsson
Acknowledgements
The LifeGene Crewincluding
Jens MattssonKicki KjaergaardMats ThurmanCamilla Björk
Thomas Bergman
The BBMRI CrewJoakim DillnerJan-Eric LittonMats Hansson
Göran HallmansUlf LandegrenJoakim Galli
Lars-Olof HanssonJoyce Carlsson
Lisen Arnheim-DahlströmSofie PetterssonMartin FranssonLoreana Norlin
Maria Anderberg
Others @ KIHenrik Grönberg
Per HallNancy PedersenRune FransonPer Spångeus
Customer RelationsTove Rylander-Rudqvist
Cecilia Björkdahl
The Biobank Crew
More infohttp://ki.se/kibiobankwww.bbmri.sewww.lifegene.se