BARBORA VLKOVÁ INSTITUTE OF MOLECULAR BIOMEDICINE …
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CIRCULATING NUCLEIC ACIDS CELL-FREE NUCLEIC ACIDS BARBORA VLKOVÁ INSTITUTE OF MOLECULAR BIOMEDICINE www.imbm.sk [email protected]
Transcript of BARBORA VLKOVÁ INSTITUTE OF MOLECULAR BIOMEDICINE …
CIRCULATING NUCLEIC ACIDSCELL-FREE NUCLEIC ACIDS
BARBORA VLKOVÁINSTITUTE OF MOLECULAR BIOMEDICINE
DNA is present in:
a) nucleus
b) mitochondria
c) cytoplasma
d) plasma
e) ...
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Nucleus
Mitochondria
GA
ER
Nucleus
Mitochondria
GA
ER
Mitochondrial DNA
Nuclear DNA
Mandel P, Metais P. Les acides nucleiques du plasma sanguin chez l'homme. C R Acad Sci Paris 1948; 142:241-243.
Extracelulárna DNA
Lo YM et al.: Presence of fetal DNA in maternal plasma and serum. Lancet 1997; 350(9076):485-7.
Research of CNA
Oncology Fetal medicine
Traumatology Blunt trauma increases CNA (gDNA & mtDNA)
Burn injuries
Correlation with clinical status & prognosis Inflammation & sepsis & transplantation Diabetes mellitus ...
Marathon & CNA
AMI & CNA
Stroke & CNA
CNA in oncology
Detection of wild-type (WT) and mutant DNA in CSF, plasma, tumor, and blood cell
Genometastasis
