BAMU B.pharmacy First Year Syllabus

Dr. Babasaheb Ambedkar Marathwada University,Aurangabad

REVISED CURRICULUMBACHELOR OF PHARMACY

(B.PHARM.)

(Including amended regulations, structure and scheme of examination)

0.527 There shall be four Examinations leading to the Degree of Bachelor of PharmacyNamely:-

(I) The First B. pharm. Examination at the end of the First Year:(II) The Second B. pharm. Examination at the end of the Second Year:(III) The Third B. pharm. Examination at the end of the Third Year:(IV) The Final B. pharm. Examination at the end of the Final Year:

0.528 The examination specified above shall be held twice a year at such places and on

Such dates as may be appointed by the University.

0.529 An applicant for admission to an examination specified in ordinance shall complete a

regular course of study in the courses prescribed for Examination concerned for not less

than one academic year in the college of Pharmaceutical Sciences recognized by the

Marathwada University.

0.530 A candidate shall be admitted to the First B. Pharm. Course if he has :-

(i) Passed the HSC (Std. XII) examinations of Maharashtra State Board of Secondary and

higher Secondary Education or its equivalent examination with

» English is one of the subjects

» Both subjects mentioned under Group - I and

» Any one of the subjects mentioned under Group - II

Group- I 1. Physics 2. Chemistry

Group-II 1. Mathematics 2. Biology 3. Biotechnology

4. Computer Science

(II) Secured minimum 50% marks (45% for backward class candidates from Maharashtra

State only) in Physics, Chemistry and the subject of maximum marks amongst the 4

subjects of Group-II, added together.

(III) Appeared for Maharashtra Pharmacy Common Entrance Test (MAH-PH-CET)

conducted by the competent authority for the academic year and secured non zero

MAH-PH-CET score.

The above eligibility criteria may be subject to change depending upon the rules

and regulations of the Govt. of Maharashtra.

0.531 A candidate shall be admitted to the Second B. Pharm if he has passed the First B. Pharm.

Examination, to the Third B. Pharm. If he has passed the First and Second B. Pharm.

Examination and to the Final B. Pharm. If he has passed First to Third B. Pharm

examination.

0.532 An applicant for admission to an Examination shall satisfy the head of the

Department/Principal in the terminal and other Test conducted during the academic year

regarding his suitability to take the Examination.

0.533 Every candidate shall be required to undergo at least one month’s Practical training

(Continuous or in Parts) at any time after the end of the Second year B. Pharm

Examination, in a Recognized Pharmaceutical Manufacturing Concern or in an

Analytical Laboratory or in a Chemical manufacturing Unit or Pharmaceutical Research

Organization or hospital (Clinical Pharmacy) failing which, he/she will not be eligible for

conferment of degree by the university.

0.534 No Person shall be admitted to any of the Examinations if he has already passed

The same examination or equivalent examinations of any other statutory university

R.646 The structure of B.Pharm Course, scheme of Examination including the maximum marks

allotted to the Sessional Examination in each paper, the written part and the practical part

for each of the Four examinations, shall be as indicated in appendices A and B.

R.647 The scope of the subject shall be as indicated in the syllabus.

R.648 The Head of the Department of Pharmaceutical Sciences/ principal shall maintain, in his

office, and a complete record of the marks obtained by the candidates in the sessional

Examinations.

R.649 The head of the Department/ Principal shall send final sessional marks secured by the

candidates to the Registrar, in a sealed cover not less than 15 days before the

commencement of examination.

R.650 In order to pass an examination, an examinee must have obtained-

(i) At least 40% of the marks in Theory (excluding Sessional Marks i.e. 32 out of

80 and 40 out of 100) and 45% of the marks in Practical (excluding Sessional

Marks i.e. 36 out of 80 and 45 out of 100) Separately in each subject and

(ii) Must have obtained at least 50% of the total marks assigned to that

examination.

R.651 (I) There shall be no classification of successful examines at the First, Second

And Third B. Pharm.

(II) The rank in order of merit of first five students shall be declared on the basis of

the aggregate marks obtained at the Third and Final B. Pharm Examination.

R.652 Division of successful examinee at the final B. Pharm Examination shall be

Declared on the basis of the aggregate marks obtained at the Third and Final B. Pharm

Examinations taken together.

R.653 The following shall be the mode of Award of Class at and examination

(I) Candidate obtaining 75% or more of Grant Total: First Class with Distinction

(II) Candidate obtaining 60% or more but less than 75% of Grant Total; First Class

(III) Candidate obtaining 50% or more but less than 60% of Grant Total: Second Class

R.654 (I) An examinee who is successful at an examination and obtains not less than

75% of the total marks prescribed in a subject shall be declared to have

Passed the examination with distinction in that subject.

Explanation:- Distinction in a subject will be awarded at the third and final

B.Pharm Examination separately.

(III) Only those candidates who have passed an examination in one attempt

Will be eligible for any prize or scholarship to be awarded for that examination.

R.655 A candidate at the first, second or third B. Pharm examination, who fails to secure

The prescribed minimum marks in not more than two theory papers and not more than

two practical examinations may at, his/her option, be admitted to a subsequent

examination in that paper or practical only on payment of fresh fee. An examinee under

this provision shall be allowed to keep terms in the nest higher class. He may take both

examinations simultaneously, but his result at the higher examination shall not be

declared unless he is declared successful at the lower examination.

R.656 An examinee failing in more than two theory papers and more than two practical may at

his/her option, appear as an ex-student at subsequent examination in the subject in which

he has failed, on payment of fresh fee.

If he clears that subjects in which he has failed he shall be declared to have passed the

examination. An examinee availing of the exemptions under the provisions of these

regulations shall not be allowed to keep terms at the next higher class.

R.657 (I) At least, three Sessional examinations will be held by the teaching institute

Every year for the purpose of internal assessment. Sessional marks will be

Calculated as the average of the best two performances at these

Examinations.

(II) A candidate failing in any of the university examinations may, at the

Discretion of the head of the department/principal be permitted, for such period as

the head of the department/principal considers necessary, to

Attend to course of instruction on the paper or practical in which he has failed as

the vase may be, in such a case the Head of the Department shall awarded to him

fresh sessional marks on the basis of his fresh performance.

(III) The revised curriculum (including regulations, structure and syllabi) will

Be in force for academic year 2006-2007 onwards for first year B. Pharm for

academic year 2007-2008 onward for second year B. Pharm for academic year

2008-2009 and onward for the third year B. Pharm, and for academic year 2009-

2010 and onward for Final Year B.Pharm.

A candidate failing in an examination with old course will have to clear that

examination with old course only. He/she will have to take the subsequent higher

examinations as per the carry on rule decided by the University.

Appendix A

STUCTURE OF B.PHARM COURSE.

The following will be the course structure of First year B. Pharm.

FIRST YEAR B.PHARM

Sr.No Subject Theory

Hours per

Week

Practical Hours per

week

1.1 Pharmaceutics-1 3 3

1.2 Biochemistry 3 3

1.3 Anatomy Physiology and Health

Education

3 3

1.4 Pharmaceutical Inorganic Chemistry 2 --

1.5 Dispensing of Medication and Hospital

Pharmacy.

3 3

1.6 Pharmaceutical Mathematics 2 -

1.7 Computer Application 1 1 D

1.8 Pharmaceutical Organic Chemistry-I 3 3

Dr.Babasaheb Ambedkar Marathwada University, Aurangabad.

Syllabus for B.Pharmacy First Year

Subject: Pharmaceutics-I (Theory)

Sr.No Theory 3 hrs./week1. Pharmacy Profession Pharmacy as a career, evolution of Pharmacy profession, earlier

period, middle to modern ages1

2. Introduction to Pharmaceutics

Definition, importance of Pharmaceutics, areas concerned, scope of Pharmaceutics, history & development of profession of pharmacy & Pharmaceutical Industry in India. A brief review of present Indian Pharma industry in global perspective.

2

3 Introduction to dosage form

Definition of drug, new drug & dosage form. The desirable properties of a dosage form, the need of dosage from, Idea about available types of dosage forms and new drug delivery system.

4

4 Route of administration

Routes of administration with respect to dosage form design, physiological consideration for various routes of administration.

3

5 ADMS Scheme of fate of dosage form after its administration, definition and introduction to concept of absorption, distribution, biotransformation & elimination of drug (without mathematical equation/factors affecting absorption). Introduction of Bioavailability & various equivalences referring Plasma-time profile of drug.

3

6 Sources of drug information

Introduction to Pharmacopoeia with reference to I.P, B.P, U.S.P & international Pharmacopoeia: study of structure/ features (index), gender notice & components of monograph of excipent, drug and drug product. Other sources: textbook, journals, internet(drug information system, online database, patient, consumer information & non-print material. Classification of information: primary, secondary & tertiary nomenclature of drug.

4

7 Unit operation in manufacturing

Filtration and Clarification: Factors affecting rate of filtration and clarification, filter media, filter aids, leaf filter, plate and frame filter, Nutsch filter, rotary drum filter and membrane filters.

2

8 Introduction to terms like desiccation, Exsiccation, Efflorescence, deliquescence, Hygroscopic, sublimation & Freeze drying.

1

9 Size reduction: importance in Pharmacy, factors influencing size reduction, grinding mills of various types like Hammer mill, ball mill, edge and end runner mill and Fluid energy mill.

3

10 Size separation: sieves, sifting, size gradation, size distribution and determination of size distribution by sieving, cyclone separator, elutriators and sedimentation technique.

2

11 Powder mixing: Mechanism of sold-solid, solid-liquid mixing, various types of trough mixers—sigma mixer, rebbon mixer, Planetary mixer and Tumbler mixer like cube, double and slant double cone.

2

12 Equipment used for manufacturing and packaging of liquids: bottle washing machine, filling equipment, belt conveyors, cartooning and batch numbering.

3

Allopathic dosage forms

Merit/demerit, importance, formulation development-vihicles/excepients with examples for the following dosage forms (No CC tests):-

2

13 Solid dosage form: powder, capsules & tablet. 414 Liquid dosage form: Monophasic liquid D.F . Aromatic water,

syrup, elixir, linctus, lotion, liniments, glycerites, solutions, spirits, ENT preparation, mixtures, paints, mouthwash.

14

15 Crude extracts Infusion, decoction, maceration, percolation, tincture & extract. Methods of preparation, Mixtures, paints, mouthwash.

3

16 Allergenic extract Types of all allergens, preparation of extract, testing & standardization of extracts.

2

17 Ayurvedic system of Medicines

Theory, basic concept, diagnosis, various branches of treatment in ayurveda, types of drugs formulation in ayurveda and important ayurvedic drug and their uses. Formulation of asavas, arishtas, watika, churna, taila, ghruta, lep.

4

18 Homeopathic System of Medicines

Theory, basic concept, diagnosis, treatment, sources of Homeopathic medicines and important Homeopathic drug and their uses.

3

19 Siddha system of Medicine

Theory, basic concept, diagnosis, treatment, diet, various siddha forms of drug, important siddha drugs and their uses.

2

20 Unani system of medicines

Theory, basic concept, diagnosis, unani medicines, various unani forms of drugs and their uses.

2

21 Aromatherapy Theory, basic concept, diagnosis, treatment and aromatic oils used in various disorders.

1

22 Biological products Absorbable & non-absorbable materials types, sutures & ligatures, processing, manufacturing, sterilization, packaging, QC tests of materials like catgut & nylon

4

23 Packaging Primary & Secondary Packaging, components of packages like container, closures, boxes, ideal package, packaging material selection & their evaluation, closures- Types pilfer proof & tamper proof packaging & child resistant packaging.

4

24 GMP Introduction to GMP, QC & QA. 2

References

1. Lachman, Liberman & Kanig, ‘industrial pharmacy’, Lee & Febiger.2. Pharmaceutical dosage and drug delivery systems-Ansel, Popovich & allen, William &

Wilkins.3. Remington: The Science & Practise of Pharmacy, Alphonso Gennaro (Mac Publishing

Company)4. Bentley’s TB of Pharmaceutics-Rawlings. (ELBS)5. Banker & Rhodes-Modern Pharmaceutics (Dekker)6. Harkrishan Singh “Pharmacopoeias and formularies” Vol I, Vallabh Prakashan, Delhi.7. Harkrishan Singh “Mahadev lal Schroff and making of modern Pharmacy” Vol IV,

Vallabh prakashan , Del 8. Harkrishan Singh” Pharmacy Practice” Vol III, Vallabh Prakashan, Delhi.9. Swarbrick & boylon-Encyclopedia Pharma. Technology (Dekker) 10. David Ganderton-Unit Processes in Pharmacy (William Heineman)11. Cooper & Gunn’s Tutorial Pharmacy12. Mittal- A TB of pharmaceutical formulation (Vallabh Prakashan, Delhi)13. Rangari VD, “ Pharmacognosy and Phytochemistry” Career Publications14. Swamisada Shiva Tirtha, “the Ayurveda Encyclopedia” Sri satguru Publications, delhi.15. Jain NK and Sharma SN, “A text book of Professional Pharmacy”, Vallabh Prakashan,

ND.

Subject: Pharmaceutics – 1 (Practical)

List of Practicals Note: Wherever possible, perform desirable inprocess & finished product quality control test like pH, density, organoleptic properties, viscosity, flow properties etc.

3 hrs/ week1 Introduction Good Laboratory Practice2 Solutions Strong solution of ammonium acetate IP, strong solution of

iodine IP, aqeous solution of iodine IP,3 Solution of ferrous iodide BPC, coal tar solution IP,4 Cresol with soap solution IP, surgical chlorinated soda

solution IP.5 Aromatic water Camphor water, cinnamon water IP 6 Peppermint water BP, conc. Peppermint water BP7 Dill water IP, conc. Dill water IP, chloroform water IP8 Glycerites Glycerin of boric acid IP, Glycerin Of borax IP,9 Glycerin of tannic acid IP, Glycerin of starch IP10 Syrups Simple syrups, syrup of lemon IP.11 Syrup of vasaka IP, syrup of tolu IP, compound syrup of

ferrous phosphate IP12 Infusions Infusion of quassia IP, conc. Compound infusion of chirata

IP, conc.13 Compound infusion of quassia BP.14 Spirits Aromatic spirit of ammonia IP, spirit of pudina IP, spirit of

nitrous ether IP.15 Tinctures Tincture of orange BP, compound tincture of benzoin IP,

compound tincture of cardamom IP.16 Liniments White liniment IP17 Lotion Calamine lotion IP18 Elixir Piperazine citrate elixir BPC, cascara elixir BPC, Paracetamol

elixir pediatric BPC.19 Linictus Simple linctus BPC20 EENT Gentamicin eye drop, chloramphenicol ear drop, ephedrine

sulphate nasal drop.21 Paints Mandles paint BPC22 Powder Oral rehydration powder, dry syrup formulation for

reconstitution.23 Ayurvedic Asava, arista.24 Taila.25 Homeopathic Preparation & standardization of one mother tincture,

potentization of preparationReference:

1. IP, BPC, NF, USP2. Remington: The science & practice of Pharmacy, alphonso gennaro (Mac Publishing

company) cooper and Gunn “Dispensing for pharmaceutical students” S.J carter


Subject: Biochemistry (Theory)

Section A

Sr.No TOPIC Hours1 Biochemistry-Introduction & Scope

Animal Cell Structure And Cell Organelles with functions-Nucleus, mitochondria, plasma membrane, ribosome, endoplasmic reticuium, lysozome, Golgi apparatus, na+K+pump, Ca++ATPase

3

2 CARBOHYDRATES – Introduction , definition , classification Mono, Di, Polysacharides. General Chemistry of carbohydrates with their Biochemical functions. Chemical reactions of monosaccharides regarding compound and osazone formation.

6

3 Proteins and amino acids:- Defination of proteins with their functions and classification based upon solubility .Protein structure at various level i.e.primary, secondary, tertiary quaternary of protein structure data base in drug design, Selected reaction of proteins and amino acid (co lour reaction ) Classification of amino acid based on structure polarity and nutrition, isoelectric point, Essential and non essential amino acid, peptide. Deferent methods of separation and purification of proteins and amino acid like chromatography, electrophoresis and centrifugation.

7

4 Lipids:- Defination and classification , structure and significance of phospholipids, essential and nonessential fatty acids , biological value of lipids, analysis of fat, acid value, saponification value, iodine value, types of lipoproteins changes in LP profile in various disease condition.

5

5 Enzymes:- Defination Nomenclature , properties and classification mechanism of enzymes action. (KM) Lineweaver plot. Factors affecting rate of enzymatic reaction. Acttvators and inhibitors of enzymes. Compititive and non compititivr inhibition with respect to drug action. Enzyme induction and isozymes with cleanical importance pharmaceutical application of enzymes

7

6 Vitamins and coenzymes :- Structure, functions and biochemical role of coenzymes from water soluble vitamins – thiamine riboflavin, Niacin, pantothenic acid, pyridoxine , Biotin folic acid cyanocobalamine and vitamin C. Biochemical role and structure role of vita mine A.D.E.K..

8

7 Nucleic acid : Nucleosides, nucleotides, phosphodiester bond structure of DNA and RNA, Nucleic acids with their classification structure, functions,. Separation and characterization technique, Functions of nucleotides, important nucleotides with their structure.

4

Section B

Sr.No TOPIC Hours1 Carbohydrate Metabolism: -

Glycolysis (aerobic, anaerobic) regulation, energetics. TCA cycle –function, regulation, significance, inhibitots, Gluconeogenesis regulation. Significance, glycogenosis, HMP, pathway with medical importance and energetics, separation and characterization technique.

7

2 Proteins and amino acid Metabolism:- Biochemical reactions of amino acids, Transamination, Oxidative and Non-oxidative demination, Deamidation and decarboxylation with example , Urea and their chemical importance, Glucogenic and ketogenic amino acids. Physiological importance of sunstances from amino (neurotransmitters) hormones.

6

3 Lipid Metabolism:- Biosynthesis of fatty acids, β- Oxidation of fatty acid, formation ketone bodies, prostaglandins and their biochemical role, cholesterol metabolism and biosynthesis.

8

4 Bioenergetics & Biological oxidation :- Definations, Energy yielding reaction, Redox potential, energy rich compounds, respiratory chain, oxidative phosphorylation with its mechanism and energetic, Cytochromes and its functions.

4

5 Genetics:- Detail study of Human genome, Genetic code, protein biosynthesis (Transcription, Translation, replication) Inhibition of protein synthesis, regulation of gene expression.

10

PRACTICALS

Sr.No TOPIC Hours1 Expression of concentration such as normality, morality, molality, percent,

gms/liters etc.Prepartion of standard buffers (citrate, phosphates, carbonate)

1

2 Qualitative tests for carbohydrates (Glucose, Fructose, Galactose, Lactose, Maltose, Sucrose, Starch, Glycogen)

6

3 Qualitative tests for proteins Precipitation reactions Colour reactionsIdentity tests for albumin, globin, casein and peptone

5

4 Qualitative tests for lipids and cholesterol 15 Quantative estimation of carbohydrate by Folin-Wu method and Summar’s

method1

6 Quantative estimation of total protein by Biuret method and Folin method. 27 Quantative estimation of DNA and RNA by Diphenylamine method and

orcinol method respectively 2

8 Quantative estimation of amino acids by Ninhydrin method. 19 Isolation of casein from milk 110 Isolation of albumin from egg. 111 Isolation of cystine from hair 112 Separation of albumin and globulin from egg by precipitation method. 113 To determine isolectric point of amino acids by (Alanine, Glycine) by pH

method.1

14 Separation of amino acids by TLC method. 115 Separation of Lipids by TLC method. 116 Electrophoresis of serum protein-Demonstration 117 Study of activity of Salivary amylase enzyme 1

Reference Books for Theory:

Outlines of Biochemistry-E.E Cohn and P.K. StumpfHarpers Biochemistry - R.K.MurryFundamentals of Biochemisry-A.C. DebTextbook of Biochemistry-Dr.O.O.AgrawalTextbook of Biochemisty-U.SatyanarayananTextbook of Medical Biochemistry-Dr. Rana ShindeTextbook of Biochemistry and Human Biology-G.P.TalwarBiochemistry-Lubert LehningerThe tools of Biochemistry-CooperBiochemistry-ZubayBiochemistry-LippincottsBiochemistry-Lubert Stryer

Reference Books for Practical:

Practical Biochemistry-David T. PlummerPractical Biochemistry-J.JayramanPractical Biochemistry-VarleyPractical Biochemistry-A.C.DebBasic Separation Techniques in Biochemistry- Okotore R.D


Subject: Anatomy Physiology and Health Education (Theory)

Section A

Sr.No Course Hrs.1 Introduction to Human body: Relation to Pharmacy, terminologies, principal

systems and their functions2

2 Cell and tissues: Cell and its structures, Function, thermoregulation. 23 Integumentary system: Skin structure and function, thermoregulation. 24 Blood: Composition, formation, functions of blood, coagulation mechanism,

blood group, blood transfusion and complications and its safety measures.5

5 Cardiovascular system: Structure, functions, conducting system, physiology of cardiac muscle contraction, cardiac output, blood pressure, cardiac cycle, neuro-humoral control of heart, ECG, structure and functions of vascular system.

9

6 Lymphatic system: Structure and function of lymphatic system, spleen, lymph gland.

2

7 Respiratory system: Parts, functions, mechanism of breathing, exchanges of gases, neural control of respiration, Lung function tests.

6

8 Urinary system: Structure and function of urinary system, mechanism of urine formation, role of kidney in regulation of blood pressure.

6

9 Fluid electrolyte and acid base balance: Mechanism, regulation and applications 2 Total 36

Section B

Sr.No Course Hrs.10 Digestive system: Structure and functions of gastrointestinal system and

accessory structures of GIT like salivary gland, liver and pancreas, mechanism of digestion and absorption.

6

11 Metabolism: Basal metabolic rate, energy production, mineral, hormones and vitamins.

3

12 Nervous system: Structure and functions of brain, spinal cord, peripheral nervous system, neuronal pathway, spinal and cranial nervous, autonomous nervous system, cerebrospinal fluid, electroencephalograph, receptors and neurotransmitters, role of hypothalamus is nervous system.

8

13 Special senses: structure, functions and mechanism of olfactory, gustatory, optic, auditory, tactile sensation.

2

14 Endocrine system: Structure, functions and regulatory mechanism of endocrine glands like pituitary, thyroid, parathyroid, adrenal, pancreas, testis, ovary.

5

15 Reproductive system: Structure and function of male and female reproductive system, spermatogenesis and menstrual cycle, pregnancy and lactation.

4

16 Osteology: Structure and functions of bones and joints, formation of bone 217 Skeletal muscle: Structure and sliding mechanism of muscle contraction. 118 Health education: Definitions, types, principles underlying health, determinants

of health, preventions of disease, immunization and vaccination, Family planning methods, role of pharmacist in health education, recent concept in health education, recent concept in health education.

8

Total 39


Subject: Anatomy Physiology and Health Education (Practical)

Sr.No Title1 Study of microscope, its working etc, and other instruments.2 Methods of collection of blood sample, anticoagulants, storage of blood sample, safety

measures.3 Estimation of hemoglobin contents and oxygen carrying capacity of blood4 Estimation of total erythrocyte count, mean corpuscular volume, mean erythrocyte

hemoglobin, mean corpuscular hemoglobin concentration, color index of blood.5 Estimation of total leucocytes count6 Preparation of blood smear slide and its examination.7 Staining of blood smear slide and estimation of differential leucocytes count8 Estimation of clotting time and bleeding time9 Estimation of blood group and typing10 Estimation of erythrocyte sedimentation rate and friability of blood.11 Spirometry: Estimation of Vital capacity, tidal volume etc12 Listening of heart sound, recording of blood pressure, pulse rate and body 13 Electrocardiogram and electroencephalogram14 Osteology: Study of skull15 Osteology: Study of axial skeleton 16 Osteology: Study of appendicle skeleton17 Histology: Tissues and muscles18 Histology: Digestive and respiratory organs19 Histology: Urinary and nervous system20 Histology: Reproductive organs21 Study of museum specimens (at least 10 from different system) / visit to the anatomy

dissection hall22 Study of charts (at least 10 from different system)23 Study of contraceptive devoice and vaccines etc. - demonstration.24 Study of working of physiograph / - demonstration.25 Study of effects of electrolytes (Potassium and calcium) and neurotransmitters (adrenalin and

acetylcholine) using frogs heart- demonstration using video tape, computer software and batch practical.

Reference books:

Theory:

1. Tortora G.J, Anagnodokos N.P.: Principles of Anatomy and Physiology, Harper & Row Publishers, New York

2. Miller M.A., Drakantoids A.B., Leavell L.C: Kimber-Gray_Stakpol’s, Macmillam Publishing Co., New York.

3. Vander A.J., Sherman J.H, Luciano D.S Human Physiology (Tata MC Graw Hill Publishing Co, New York

4. Chakrabarti B,K, Ghosh H.N Sahaha S.N Human Physiology, New Book stall, Calcutta5. Ganong W.F, Review of Medical Physiology, Prentice Hall International, London6. Keele C.A, Neil E, Joels N: Samson Wright’s Applied Physiology, Oxford University

Press7. Guyton A.C Text bookj of medica; Physiology, W.B Saunders Co. Philadelphia8. Mc-Naugh A.B Callander R, Illustarted Physiology, B.I Cgurchill, Livingstone, New

delhi9. West J.B Best and Taylor’s Physiological Basis of Medical Practice, Williams and

Wilkins Baltimore10. Mountcastle: Medical Physiology11. Chatterjee C.C Human Physiology, Medical Allied Agency, Calclutta12. Park J.E, Perk K, Text book of Preventive and social Medicine, M/S Bhanot Publishers

Jabalpur13. Chaurasia B.D, Human Anatomy, Regional and applied, CBC Publisher, New Delhi14. Creager J.G Human Anatomy and Physiology, WC Brown Publisher15. Martini: Fundamentals of Human Anatomy and Physiology, Prentice Hill16. Martini: Human Anatomy, Prentice Hill17. Keele, Neil, Joels: Samson Wrignts Applied Physiology, Oxford University Press18. Sircar S: Medical Physiology, CBS publications19. Schmidt .F thews G: Human Physiology, Springer Verlag20. Datta A.K Essentials of Human Anatomy, Current Book International21. Shalya S: Human Physiology, CBS Publisher and Distributors22. McNaught A.B, Callander R: Illustrated Physiology, Churchill Livingstone.23. Parmar N.S: Health Education and Community Pharmacy, CBC Publisher and

distributors.

Practical:

1. Ranade VG Prashan S., Joshi P.N: A Text Book of Practical Physiology, Pune Vidyarthi Graha Prakashan, Pune.

2. Goyal R.K., Patel N.M shah S.A Practical Anatomy and Biochemistry, B.S Shah Prakashan, Ahmedabad

3. Anatomy and Physiology Laboratory Manual, Mosby4. Di Fiore Mariano S.H., Atlas of Normal Histology, Lea and Febriger Philadelphia5. Deb A.C., Fundamental of Biochemistry, New Central Book Agency, Calcutta6. Chaurasia B.D.: Human Osteology., CBS Publisher and Distributors, New Delhi7. Singh I.B., Text of Histology, CBS Publisher and Distributors, New Delhi8. Ghai C.L: A text Book of Practical Physiology, Jaypee Publication9. Inderbir Sing: Text book of Human Histology, Jaypee Publication10. Jain A.K Manual of Practical Physiology, Arya Publication.


Subject: Pharmaceutical Inorganic Chemistry (Theory)

1. Pharmacopoeia and Monograph-different pharmacopoeias and general contents of

official Monograph. 3 Hrs

2. Impurities and factors affecting the purity of pharmaceuticals, Limit test for chlorides,

sulphates, arsenic, iron, lead, heavy metals as per I.P. 6 Hrs

3. Water- Hardness of water, method to remove hardness of water, different official

waters, official tests for quality control of water. 2 Hrs

4. Nuclear Chemistry- Structure of Nucleus, Methods of nuclear radiation measurement,

Nuclear reactions, fusion and fission, Radiation dosimetry, Radioopaque contrast

medium. (Therapeutic and diagnostic applications of radiopharmaceuticals, Iodine

131, Phosphorous-32, Chromium-51, Cobalt-60, Iron-59, Tc 99 Quality control of

radiopharmaceuticals.) 5Hrs.

5. Electrolytes- Extra and intracellular ions: Chloride, Phosphate, Bicarbonate, Na, K,

Ca, Mg. Electrolytes used for replacement therapy, physiological acid base balance,

Electrolytes used in acid base therapy, Electrolytes combination therapy. Sodium

chloride injection, Ringer Solution lactated, Ringer injections, sodium acetate,

potassium acetate, sodium bicarbonate, potassium bicarbonate, sodium citrate,

sodium lactate, ammonium chloride.

6. Antidote Classification, sodium thiosulphate, sodium nitrite 1 Hrs

7. Dental products 2 Hrs

SECTION B

8. Pharmaceutical Aids and Necessities- Acids, Bases, Buffers, Antioxidants, Preservatives,

Adsorbents, Diluents, Excipients, Suspending agents, Colors and Flavors. 4 Hrs

9. Essential and Trance ions- Absorption, Distribution, Physiological role. Official

Compounds of Fe, Cu, Zn, Mn, I Fe- Ferrous sulphate, Iron Sorbite injection, Ferric

Ammonium citrate, Ferric chloride 6 Hrs

I-Iodine, Potassium Iodide, Sodium Iodide.

Zn- Zinc Sulphate.

10 Gastrointestinal agents: Acidifiers, Hydrochloric acid, Antacids-sodium

Bicarbonate, aluminum hydroxide, magnesium carbonate, magnesium hydroxide

protective and absorbents- bismuth subcarbonate, kaolin. Laxatives, purgatives and

cathartics- magnesium sulphate. 6 Hrs

11 Topical agents: Protectives- Talc, Zinc oxide, Silicon polymers, Anti microbial and

Astringents- Hydrogen peroxides, potassium permanganate, iodine solutions, sulphur,

boric acid, alum 5 Hrs

12 Expectorants: Emetics and their official compounds- Ammonium chloride, potassium

iodide, sodiumchloride, coppersulphate and antitussives. 2 Hrs

13 Important Official gases used in Pharmacy Oxygen, Nitrogen, Nitrous Oxide, Carbon

dioxide, Helium, Ammonias and their compounds as per I.P 2 Hrs

Reference Books:

1. Inorganic Medicinal and Pharmaceutical Chemistry-J.H. Block, E.B Roche & I.O.

Soine, C.O Wilson (Varghese Pub)

2. Modern Inorganic Pharmaceutical Chemistry- C.A Discher

3. Bentley and Driver’s Textbook of Pharmaceutical Chemistry

4. Remington: The Science and Practice of Pharmacy-Alfonso R. Gennaro (Mack)

5. Indian Pharmacopoeia, Latest edition

6. Practical Pharmaceutical Chemistry Part I & Part II- A.H Beckett & J.B Stanlake

(CBS)

7. Vogel’s Textbook of Quantitative Chemical Analysis (ELBS)

8. A Textbook of Micro & Semi micro Qualitative inorganic analysis by Vogel.

9. Human Physiology- Chatterjee.


Subject: Dispensing of Medication (Theory)

Sr.No Topic Sub Topic Hrs.

1 Introduction Introduction to dispensing, Compounding and Hospital Pharmacy

2

2 Prescription Definition, Parts, Stages in Handling, methods for pricing, Ideal prescription.

4

3 Weight and measures system

Imperial and metric system, Their inter-conversion, common Household measures.

2

4 Pharmaceutical Calculations

Percentage Calculations, Allegation method, Proof sprit, Isotonic solutions, Dosage calculations (including factors affecting dosage calculations), Dilutions, Reducing and enlargement of formula.

2

5 Fundamental operations in compounding.

Weighing and measuring techniques, Different types of balances, Measurement apparatus, Mixing, Dissolution, Size reduction, Filtration, Size separation (only for dispensing).

2

6 Labeling techniques for dispensing

Requirement for labeling of dispensed medications, labels for different types of dosage forms with specific directions, caution or advice, Storage conditions, Definitions of Various terms of storage conditions. Concept of Shelf life and Expiry.

2

7 Containers and closers for dispensing of medications.

Definitions of primary, secondary and tertiary packaging, ideal package, Different types of glass and glass containers for dispensing, Plastic and aluminum packaging materials, Unit dose and multi dose packaging.

3

8 Incompatibility Definitions, types, with examples and corrections. (from Cooper and Gun’s Dispensing Pharmacy)

3

9 Compounding and dispensing of following Dosage forms. A Solutions Definition, formulation and compounding,

solution for oral use, dilution of solution, solution to be instilled in to body cavity, solution for external use with examples, containers, storage, shelf life.

2

B Emulsion and creams Definitions, types, identification, Emulsifying agent classification with examples, choice of emulsifying agent for oral and internal use, HLB value its use and calculation, preparation of emulsion by Dry gum, wet gum and bottle method. Emulsion for oral use (acacia emulsion), Emulsion for external use (liniments, lotions, applications). Definition of cream, general method for

3

preparation of creams, dilution of creams, storage, containers, and shelf life.

C Suspension Definition, Advantage and limitations, types, suspending agents, desirable properties of suspension, compounding of suspension containing diffusible substances and indiffusible substance, poorly wettable solids, suspension containing precipitate forming liquid and volatile oil inhalations. Shelf life, containers, labeling, directions and storage.

3

D Ointments/ Pastes Definitions, ointment bases with properties, advantages, limitations and examples, additives in the ointments, method of preparation, Containers and packing, directions and storage.

3

E Plasters and poultices Definitions, different types of plasters and their use, Kaolin poultice.

2

F Gels Definitions, different types, Method of preparation, different gelling agents used Containers and packing, directions and storage.

2

G Powders Definitions, Advantages and limitations, Classification, characteristics of powders, Method of preparation for compound bulk powder, its packing, Powders for external use dusting powders, dentifrices, insufflations, douches, Wrapping techniques, double wrapping. Definition of granules, general method of preparation, advantages of granulations, Effervescent granules-its composition, preparation, and packing, directions and storage.

3

H Suppositories and passaries.

Definitions, Advantages and limitations, Different types of bases used with advantages, limitations and examples, concept and calculation of displacement value, description of mould, mould calibration, mould lubrication, method of preparation with coca butter glycerol-gelatin bases, PEG bases, Containers and packing, directions and storage.

3

I Capsules Definitions, different types, Sizes of hard gelatin capsules, Method of filling-manual method, hand operated capsule filling machine, Simple capsule filling apparatus. Containers and packing, directions and storage.

2

J Tablets triturates & tables

Dispensing & compounding of tablet triturates. Dispensing from bulk containers, packing, and directions.

1

K Pills Definitions, Advantages and limitations, Major 1

ingredients, method of preparation, Containers and packing, directions and storage.

L Lozenges and pastilles Definitions, Comparison, Major ingredients, method of preparation, Containers and packing, directions and storage.

1

HOSPITAL PHARMACY

10 Introduction to Hospital

Definition, Types, Functions, Layout of hospital Organization (No details of each Dept.)

2

11 Introduction to Hospital Pharmacy

Definition, History and development, layout and manpower requirement, Objectives and Scope.

1

12 Functions and responsibilities of Hospital Pharmacists

For Inpatient (For patient care areas, Direct patient care, Central dispensing areas and general), Out. Ambulatory patients.

1

13 Patient Counseling and communication skill.

Need for counseling, areas for counseling to the patient. Counseling for inpatient, out patient and while discharge of patient. Assumptions and expectations in communications, Techniques for effective communications, barriers and problems in the communications (only related to patient counseling).

2

14 Pharmacy and therapeutic committee

Definition, objectives, Composition, working, Functions, Role in Drug Safety, Adverse drug monitoring and developing emergency drug list.

2

15 Hospital Formulary Definition, objective, Advantages and limitations, Method and rules for preparation and Contents

1

16 Dispensing procedures and drug distribution systems.

For In patients. Out patients. Controlled medications, for hospital wards and emergency situations.

3

17 Central sterile services dept.

Definition, Objective, functions, Advantages, management, location Lay out, Flow of materials, Staff required.

1

18 Sterilization in hospital pharmacy.

Introduction to diff. methods of sterilizations, (No details of equipments and workings.) Sterilization method for powders, ointment, rubber Gloves, syringes, needles, Catheters, surgical materials (cotton and bandages).

2

19 Medical Gases Definitions, Different examples, Color-coding, Accessories required for gas therapy. Therapeutic applications.

2

20 Radio Pharmaceuticals Definition, Types of Radiations, Half life, Therapeutic and diagnostic Radiopharmaceuticals, Facilitates required for preparation, Protection of operator, Radio Pharmaceutical Kit.

2

21 Surgical instruments & Health Accessories

Surgical instruments, Wheel Chairs, Canes, Crutches, Bed Pans, Vaporizers, Syringes,

2

Needles, Thermometers, First Aid, Hot Water bottle (No Diagrams) only with respect to prescription dispensing and patient counseling.

22 Hospital Pharmacy a Global Scenario including National health scheme

Hospital Pharmacy a Global Scenario including National health Scheme (NHS)

1

23 Use of computers in Hospital Pharmacy

Application of the computers in the hospital pharmacy.

1

24 Surgical dressings Surgical dressings, properties, absorbent dressings, wound dressings, bandages, surgical adhesive tape, protectives, plasters, standard for dressings and packaging.

2

Reference books

1) Remington’s Pharmaceutical sciences – A.H. Gennaro (Mack Publication)

2) Pharmaceutical practice – Collett & Aulton (Churchill Livingstone)

3) Dispensing of medications – Hoover (Mack Publication)

4) Prescription pharmacy – Sprowls (Lippincots)

5) Pharmaceutical – Bradley (Lea & Febiger)

6) Dispensing for pharmacy students – Cooper & Gunn, S.J Carter (CBS

publisher & distributors)

7) USP – Official

8) IP, BP, USP-NF, NFI & the Pharmaceutical Codex – Official

9) Martindale extra Pharmacopoeia – Official

10) Introduction to Pharmaceutical calculations – J.A Rees, I. Smeeth & B. Smith

(Pharmaceutical Press)

11) Pharmacy practice – P. Stone & S. J. Curtis (Pharmaceutical press)

12) Pharmaceutical Practice – A. J. Winfield, R.M E Richards (Churchill

Livingstone)

13) Hospital & clinical Pharmacy – H.P Tipnis, M. S. Nagarsenkar (Nirali)

14) Hospital Pharmacy – Quadri and Shaha


Subject: Dispensing of Medication (Practical)

Notes:

1 All the prescription shall be in metric system except a few for practice which shall be the imperial system.

2 Latest editions of books wherever applicable shall be used.

3 Special attention to be paid to the cleanliness and precise working (Including documentation) of the candidate in the laboratory.

List of experiments 1 Study of Dispensing vs., Compounding2 Study of weighing techniques for dispensing balances, sensitivity, weight box accuracy,

precision of weighting.3 Measuring techniques: precision & accuracy of measuring, devices for doses

measurement4 Prescription handling: Dispensing of an ideal prescription with reading, checking,

labeling & dispensing with detailing.5 Good pharmaceutical Practices in compounding & dispensing.6 Study of different surgical materials7 Comparative study of dispensing labels with marketed preparations labels (of all dosage

forms, minimum 25 labels)Compounding & Dispensing of the following preparations

Powders & granules8 Compound magnesium trisilicate oral powder

Isabgol granules9 Zinc starch and talc dusting powder

Effervescent granulesEutectic powders containing menthol & camphorSolutions

10 Salicylic acid collodionPediatric ferrous sulphate oral solutionZinc sulphate & Zinc chloride mouth washSuspensionPaediatric kaolin mixture Magnesium trisilicate mixture

11 Paediatric chalk mixtureInhalation containing menthol & eucalyptus.Emulsions

12 Emulsion for internal use containing acacia (any 2 emulsions)13 Oily calamine lotion

Benzyl benzoate applicationOintment

14 Sulphur ointmentWhitfields ointment

15 Methyl salicylate ointmentLubricating jellySuppositories

16 Calibration of moulds, calculation of displacement value for the given drug.Suppository with fatty base

17 Suppository with PEG baseCompounding of following preparations

18 Topiicals containing ointment/cream with powders, liquids and finely powdered tablets of antibacterial, anti-inflammatory & corticosteroids.

19 Anti-diarrhoel powder for paediatric containing anti bacterial, antispasmodic, antiaemoboc with kaolin & pectin.Mouthwash containing Thymol, Menthol, Peppormint oil and an suitable antiseptic.

20 Scalp lotion containing Mercuric chloride, Panthenol & a hair conditioning agnets, etc Mixture of salts excluding sodium chloride for use as a substitute in hypertension

21 Lozenges, Pastilles.22 Pills, Tablet triturates.23 Capsules & solid unit dosage forms & their preparations.24 Prepackaging & dispensing of Paracetamol/ Trimethoprim/ Sulpha tablets.25 Drug information – source – an exercise on drug information.26 Practical based on the concept of Hospital Pharmacy.

Reference:

1. Pharmaceutical practice- Collett & Aulton (Churchill Livingstone)2. Prescription Pharmcy- Sprowls (Lippincots)3. Remington’s Pharmaceutical Sciences – A.H. Gennaro (Mack Publication)4. Introduction to Pharmaceutical Calculations – J. A. Rees, I. Smeeth & B. Smith

( Pharmceutical Press)5. Pharmcy Practice – P. Stone & S.J. Curtis (Pharmaceutical press)6. Dispensing of medications – Hoover (Mack Publication)7. Pharmaceutical Practice – A. J Winfield, R.M. E. Richards (Charchill Livingstone)8. Dispensing for Pharmacy Students – Cooper & Gunn9. The Extra Pharmacopoeia – Martindale10. Merck Index 11. USP – Official12. IP, BP, USP-NF, NFI 7 the Pharmaceutical codex – Official13. Martindale extra Pharmacopoeia - Official


Subject: Pharmaceutical Mathematics

Sr.No Course Hrs.1. Significant figure

Fraction, Exponents, Powers and rootsRatio & proportionsLogarithms

06

2 Calculus:Function and limitsDerivativesIntegral calculusIntroductory aspects of Laplace transformation

6771

3 Integral Calculus:Integration by decomposition, by substitution, by parts and by successive reductionIntegration of algebraic rational functionIntegration of trigonometric function

2222

4 Graphical representations:Need, types of graph

2

5 Basic statisticsData & data handling Averages, Mode, median,Data scattering: Range, Quartile, Mean deviation and standard deviation

5

6 Correlation 27 Regression 28 Introduction of testing hypothesis 29 Introduction of sampling

Population in samples, Choosing random samples, sampling distribution of mean.

2

Reference Book:

1. F. Daniels Mathematical preparation for physical chemistry, McGraw Hills, New York 1928.

2. W. Lowenthal, Pharmaceutical calculation, in Remington’s Pharmaceutical Sciences, A.R Genaro, Vol-1, Editor, Mack Publishing, Easton, PA, 2004,. P.103

3. Sanford Boltan, Pharmaceutical statistics, Vol-80, 1997 Marcial Dekker Incoporation New York, p.39-61, 120-187, 190-214, 216-263.

4. G.V. Kumbohjkar, Engineering Mathematics for first year Diploma, Phadake Prakashan, Kolhapur.

5. G.D Christian, Analytical Chemistry, Jhon Willey and Sons 1994, P.146. Shanti Narayan Integral Calculus, S.Chand and Co. Ltd New Delhi, 2004, P.1-112

7. Steve Dobbs and Jane Miller Statistics 1 and 2 Cambridge university Press 2003, P. 54-135 John Stillwell Mathematics and its history, second edition, Springer 2000, P.146-169.


Subject: Computer Application (Theory)

Sr.No Course Hrs.1 Computer Fundamentals: The basic anatomy of Computers, Components of

Computer System, Classification of Computer, Number System, Input/ Output Devices, Processors & Memory, Secondary Storage Devices, Software & Hardware

5

2 Introduction of Microsoft office components as MS-Word, Excel, PowerPoint & Access

5

3 Introduction of ISIS Chemical Structure drawing Utility 14 Programming: Algorithm, Flow chart, Introduction to languages, C

Fundamentals: Operators & Expressions, Data Types, Statements, Looping, Functions, Program Structure, Arrays, Introduction to Pointer

7

5 Networking: Need & Advantages of Networking, Networking Concepts, Topologies, Networking Types, Addressing Schemes

2

6 Internet: Introduction to internet & intranet, Protocols, TCP/IP, Basic Services of Internet, Connecting & Browsing, E-Mail, Chat, Downloading, Search Engine, Introduction to HTML

3

7 Application of Computers in Pharmacy & Drug Design 2


Subject: Computer Application (Practical)

Sr.No Title Hrs.1 MSDOS: Introduction to DOS, Internal/External Commands, Batch Files

and various other commands2

2 Windows: Introduction to Windows, Desktop, Creating Folders, Shortcuts, Windows Elements, Notepad, Wordpad, Calculator, paint & other tools of Windows

2

3 MS Word: Creation of Documents, Formatting of document, working with Tables, Mail Merge

3

4 MS Excel: Creation of Worksheet, Formatting of Worksheet, Functions, Chart Creation, use of excel to solve laboratory problems & data analysis

4

5 MS PowerPoint: Creation of Slides, Formatting of Slides, Slides layout, Slide Show settings

2

6 MS Access : Creation of Tables, Query, Forms, Reports 27 C Programming: Programs related to Operators, If Statement, Looping,

Switch, Arrays, Pointers4

8 Internet: Internet Connectivity, Browsing, creation of E-Mail A/C., 29 HTML: Creation of Web Pages, Various tags used for creation of sample

Web page2

10 Draw at least 10 Structure using ISISI 211 Draw at 5 to 6 step organic chemical reaction using ISISI 1

Reference Book:

1. Foundation of Computing By P.K Sinha / Priti Sinha (BPB Publ.)2. The C Programming Language by Kernighan & Ritchie – PHP3. Exploring C By Dennis Ritchie4. System Analysis and Design by Elias M. Awad5. Internet in a nutshell by Alexis Leon, Vikas Publications, New Delhi6. Computer applications in Pharmacy, Basat7. IBM Computers 8. Remington:The Science and Practice of Pharmacy, Lippincott Williams and Wilkins.


Subject: Pharmaceutical (Organic) Chemistry-I

Section-A

1. 1. Hazards and safety in chemical Laboratory 1 hr. 2. Atomic Structure: Atomic orbitals, electronic configuration of atoms, definitions - ionic

radii, ionization potential, electron affinity, electro negativity, afbau, Pauli exclusion principles, concept of Hybridization- types, Types of bonds- covalent, coordinate, ionic and hydrogen bond 5 hr

3. IUPAC nomenclature:Structure, Nomenclature (multiple groups) aromatic, hetero cyclic compounds containg two hetero atoms 6hr

4. Preparation and reactions of: alkane, alkene, alkyne, alcohol, ethers and epoxides, alkyl halide, amine, nitro compounds, phenols, aldehyde and ketones, carboxylic acid and functional derivatives of carboxylic acids including ketoester (mechanism of reaction to be covered) 15 hr

5. Classes of reactions and classes of reagents: Including elecrophile, neucleophile and radicles 1 hr

6. Transient reaction Intermediate: Carbocation, carbainion, and carbenes. Generation, structure, stability and reaction. Kinetics and thermodynamic control of reaction. 4hr

7. Theories of acidity and basicity with respect to organic compounds: Factors affecting acidity and basicity. Resonacnce, inductive effect and hydrogen bonding. 5hr

Section-B

8. Factors affecting electron availability in bonds and individual atoms: electro-negativity, inductive effect and resonance effect, hyper conjugation, including rules of resonace, concept of tautomerism, and types of tautomerism. 5hrs

9. Introduction to stereoisomerisms: configuration, conformation, and concept of optical isomerism in compounds containing one asymmetric carbon atom. Isomerism and types of geometrical isomerism- Z and E Nomenclature cis & trans naming cahn-ingold-prelog system for assigning Z and E Nomenclature. 5hrs

10 Nucleophilic substitution at saturated carbon: SN land SN 2 mechanism and stereochemistry (compounds containing one asymmetric carbon atom only)Factors affecting substitution: Substrate structure Nature of neucleophile Nature of leaving group and solvent. 5hrs

11 E1 and E2 elimination: Mechanism and stereochemistry of Saytzeff and Hoffmann rules, factors affecting for substitutions vs. elimination. 5hrs

12 Conjugated diene: Structure, elecrophilic addition to dienes, 1, 2 & 1, 4 addition Diel’s Alder ration 2hrs

13 Benzene and aromaticity: Huckel Rule, resonance in benzene and derivatives. Mechanism of electrophilic substitution reactions. Halogenation, nitration, and aromatic

substitution. Craft reaction. Orientation and reactivity of electrophilic and aromatic substitution. Mechanism of neucleophilic aromatic substitution reaction involving benzyne intermediate. 8 hrs

14 Common organic reactions, mechanism and applications.Aldol cannizaro, Perkin, Stobbe, Dickmann condensation Hofman-Schmidt, Losen curtius, Beckmann, and Fries. Reimer-tiemann, Reformatsky, and Grignards reaction, Claisen, Witting reaction, and oppenaur oxidation, clemmensen, wolfkishner, MPV, and Birch reduction. 8hrs

BAMU B.pharmacy First Year Syllabus

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Transcript of BAMU B.pharmacy First Year Syllabus