Balance Hormones without a Prescription - Revive...
Transcript of Balance Hormones without a Prescription - Revive...
Hydroxyprogeterone
Hydroxypregnenolone
Corticosterone
Deoxycortisol11-Deoxycorticosterone
18-Hydroxycorticosterone
Androstenediol
Estrone Estradiol
16-a-Hydroxyestrone
2-Hydroestrone
2-Methoxyestrone2-Methoxyestradiol
Dihydrotestosterone (DHT)
Androstanediol
Na+/ K+ Balance Anti-InflammatorySugar Stabilizer
5-a-reductase metabolites
2-hydroxylation metabolites
16-hydroxylation metabolites
Pregnenolone
Progesterone
Aldosterone
Cholesterol
Testosterone
Dehydroepiandrosterone
DHEA
Androstenedione
Cortisol
Estriol
Drugs Pesticides
Food additivesHormones Histamine
Liver Detoxification
PHASE I
*500-1,000 enzymes * SulfationCYP450 *Glucuronidation
* Acetylation* Oxidation * Glutathione/aa* Reduction conjugation* Hydrolysyis * Methylation
PHASE IITOXIN
BIOTRANSFORMATION
Assessment
Tests Saliva Test Blood Test Stool Test
Symptom Survey GI Liver Toxicity Sympathetic dominance Hypo/Hyper adrenal Hypo or hyper thyroid Sugar Deregulation
Regland’s Test Temperature
Test Iodine Test
Liver/Gallbladder
Detoxify hormones, drugs, and chemicals Hormones are altered or excreted
Thyroid Most steroid (estrogen) hormones
Can lead to excess accumulation of hormones
Formation of Bile Storage of vitamins and iron Formation of factors used in blood coagulation
Estrogen Metabolism
Hydroxylation 2 hydroxyestrone (Good/weak) 4-OH and 16 OH (Continued proliferation activity)
Cruciferous vegetables
Methylation By COMT enzymes
Glucuronidation Some enzymes in gut can compromise this
Detox Recommendations
Milk Thistle and/or silyamarin
Artichoke Juniper Berry Yellow Dock Oregon grape Dandelion
Beets and beet root Bovine liver Defatted wheat germ Burdock Chaparral Green Cruciferous
Veg.
Liver/Gallbladder Toxicity
Dry skin Itching skin and feet Rashes Bitter metallic taste Greasy, milk foods
upset, cause pain or watery stool
Low thyroid symptoms
Bad Breath Headaches Falling Hair Pain in area Hormone issues
Liver Problems can cause Thyroid Problems
Need selenium for actions May need to detox liver (phase 1 & 2
detox pathways) Liver repair if needed with liver
protomorphagen
Yeast Spit Test
First thing in the morning spit in a glass of room temperature filtered water and watch every 15 minutes
Yeast Indicated if: Cloudy String
Stomach and Small Intestine
Gastrin Stimulates HCl production in stomach
Small Intestine CCK (Cholecystokinin)
Gallbladder Contraction Release of pancreatic enzymes
Secretin Stimulates pancreas to release Sodium Bicarbonate to
increase pH
Link Between Thyroid and Pathogens
Several studies show a strong link between AITD (both Hashimoto’s and Graves’) and gluten intolerance.
Yersinia enterocolitica (Graves) Yeast
Recommendations
No Stomach Acid or digestive enzymes Betaine Stomach tissue factors Pancreas enzymes and glandular Pepsin
Too Much Acid (Mucus building herbs) Okra Aloe Vera Marshmallow Slippery elm
Recommendations
Reflux Meadowsweet Chamomile Licorice Aloe Vera Gel or juice
Toxins in Bowels Bentonite Clay Chlorophyll capsules
Healers Apple Pectin Collinsonia Root
“Vascular astringent” Hemorrhoids
Thyroid
T4 (Thyroxin) Turned into T3 mostly in liver
T3 (Triiodothyroxine) Stimulates metabolism in cells
Calcitonin Promotes calcium intake into bones Decreases extracellular calcium
Diet Mostly raw foods to give pancreas a break
Salads Dressings with herbs and vinegar
Vegetables Juices
Fresh organic fruit Pectin
Prebiotic Decreases testosterone and estrogens
Fermented Foods with good bacteria Raw cheese, milk yogurt Cultured or fermented vegetables, Kefir Kombucha Raw apple cider vinegar
Lean Proteins
Thyroid Natural Balancers
Bacopa found to increase T4 in animal studies
Bladderwreck has iodine Prolamine Iodine Thyroid Protomorphagen
Glandulars
Whole Glands Only used short term because of atrophy Contains all factors of the glands
Hormones Enzymes Tissue Factors
Thyroid Adrenal Thymus Spleen
Hypoadrenal
Weak nails Chronic fatigue Crave salt and sugar Brown spots Respiratory Disorders Swollen Ankles
Circulatory Disorders Dizziness when you
get up quickly Depression Tired
Whole Food Nutrition vs. Drug Store Vitamins
Regular Vitamins made like drugs High quantities of a chemical extractions A scientist decided this ingredient was the most active
Whole Food Supplements Should be organic when possible Contains complexes with things that have not been
studied Digested, metabolized, utilized and excreted like food
Glandulars: Cytosol Extracts
Cytosol Extracts From cell cytoplasm which is inside the
membrane of the cell The cytoplasm is the site where most cellular
activities occur, such as many metabolic pathways like glycolysis and processes such as cell division.
Used in more acute cases
Protomorphogens
Can be used long term Extracts of nucleic acids from cell nucleus
RNA (Ribonucleic) messenger, transfer, ribosomal DNA and Protein synthesis
DNA (Deoxyribonucleic acid) Contains genetic instructions in development and functioning
of all living things Carries the “genes” Held together by sugars and phosphate
Recommendations
Phosphorylated Serine Organic Minerals Vitamin C complex in whole food supplement Adrenal Protomorphagen Desiccated anterior pituitary Manganese Calmative Herbs with withinia, St John's Wort,
Schisandra, Damiana and Skullcap Calcium Vit E2 Complex
Recommendations
Desiccated adrenal 2 times a day for 30-45 days
Vitamin B whole food complex Vitamin C whole food complex Vitamin B12 Trace Minerals Licorice
AdaptogenRefers to a natural herb product that is proposed
to increase the body's resistance to stress, trauma, anxiety and fatigue
Eleuthero Licorice Maca Holy Basil Ginseng Rhodiola
Schisandra Ashwagandha/Withania Cordyceps Noni Chaga mushroom Reishi mushroom
Licorice Licorice has antispasmodic, anti-inflammatory, laxative,
and soothing properties May block metabolism of prostaglandins E and F2 alpha Reduces conversion of Cortisol to inactive cortisone in the
kidneys Licorice decreases testosterone production in men who
eat licorice Likely due to glycyrrhetinic acid inhibiting the enzyme 17-
hydroxysteroid dehydrogenase, which converts androstenedione to testosterone
Glycyrrhetinic acid also seems to inhibit 17-20 lyase which converts 17-hydroxyprogesterone to androstenedione
Reference: Natural Medicine Comprehensive Database
Licorice
Uses: Adrenal insufficiency
(Addison's disease) Aplastic anemia Apthous ulcers / canker sores Atopic dermatitis Bleeding stomach ulcers
caused by aspirin Dental hygiene Dyspepsia (functional) Familial Mediterranean Fever
(FMF) Herpes simplex virus High potassium levels
resulting from abnormally low aldosterone levels
HIV Hyperprolactinemia
(neuroleptic-induced) Idiopathic
thrombocytopenic purpura Inflammation Polycystic ovarian
syndrome Reducing body fat mass Upper respiratory tract
infections Viral hepatitis (SNMC) Peptic ulcer disease
Ashwaganda/Withinia
Adaptogen Sedative Anxiolytic Analgesic Antipyretic Immunomodulatory Hypotensive Anti-inflammatory Antioxidant effects Stimulate respiratory function Smooth muscle relaxation Stimulate thyroid synthesis and/or secretion
Thyroid
Thyroxin (T4)and tri-iodothyronine(3) essential for normal organ growth,
development and function. regulate the basal metabolic rate of all cells,
including hepatocytes, and thereby modulate hepatic function;
the liver in turn metabolizes the thyroid hormones and regulates their systemic endocrine effects.
Thyroid Conversion
The thyroid gland secretes 110 nmol of thyroxine(T4) 10 nmol of tri-iodothyronine(T3) each day.16 T3 has ten times greater affinity and efficacy than T4
for the nuclear receptor, There are t 3 groups of enzymes that regulate thyroid hormone
metabolism, forming part of the iodothyronine seleno-deiodinase enzyme system They are responsible for the activation of T4 to T3
Hypothyroid
Gaining weight inappropriately or unable to lose weight My "normal" body temperature is low Frequently feel cold Fatigued, exhausted more than normal Hair is rough, coarse dry, breaking, brittle, or falling out Skin is rough, coarse, dry, scaly, itchy and thick Nails have been dry, brittle, and break more easily Voice has become hoarse, husky or gravelly Feeling depressed, restless, moody, sad Difficulty concentrating or remembering things Puffiness and swelling around the eyes, eyelids, face, feet, hands
and feet
Bacopa (Brahmi)
Memory Possible mechanisms for cognitive improvement
include modulation of acetylcholine release, choline acetylase activity, and muscarinic cholinergic receptor binding
Thyroid effects:(200mg/kg) leaf extracts increased T(4) concentration in
male mice, suggesting its thyroid-stimulating role
increased T(4) concentration by 41% without enhancing hepatic lipid peroxidation (LPO), hepatic LPO was decreased and superoxide dismutase
(SOD) and catalase (CAT) activities increased showing its antiperoxidative role
Hyperthyroidsm
Graves Disease Autoimmune Excessive T4
Hashimoto’s Thyroiditis Autoimmune Thyroid burns out to hypothyroidsm
Link to anaerobic bacteria Link to celiac(5 times more thyroid problems)
Yesina Oregano oil, berberne(Golden seal), Garlic, Coconut oil,Black hull, cat’s claw, pH balancer to promote growth of important gut bacteria Prebiotic and probiotic
Recommendations
Liver Cleanse Natural Anti-biotics Thyroid Protomorphagen Iodine Trace Minerals Calcium/Magnesium Calmative herbs
Peri menopause and Menopause
Decrease of Progesterone from Corpus Luteum (peri)
Menopause “Loss of ovarian function characterized by cessation of menses ↓ Estrogen ↓ Progesterone ↑ LH ↑ FSH
Hydroxyprogeterone
Hydroxypregnenolone
Corticosterone
Deoxycortisol11-Deoxycorticosterone
18-Hydroxycorticosterone
Androstenediol
Estrone Estradiol
16-a-Hydroxyestrone
2-Hydroestrone
2-Methoxyestrone2-Methoxyestradiol
Dihydrotestosterone (DHT)
Androstanediol
Na+/ K+ Balance Anti-InflammatorySugar Stabilizer
5-a-reductase metabolites
2-hydroxylation metabolites
16-hydroxylation metabolites
Pregnenolone
Progesterone
Aldosterone
Cholesterol
Testosterone
Dehydroepiandrosterone
DHEA
Androstenedione
Cortisol
Estriol
Ovary and Uterus
Ovarian cycle depends on FHS and LH from anterior pituitary Target specific receptors on ovary which stimulate
enzymes to make hormones FSH and LH surge coincides with ovulation around
day 11
Problems Could they breast feed Brain Trauma
Questions
Hot flashes Night sweats PMS Painful Breasts Acne Depression
Sleep Scanty or missed
period Hysterectomy Headaches Dizziness Mood swings
Iodine
Needed for thyroid to work Goiter Myelination of the central nervous system
Need more during pregnancy Decreases fibrotic breasts
Bio-identical Hormones
Hormones made in a compounding pharmacy to look chemically like human hormones Yam Soy
Problems Dose Negative feedback mechanism
Problem Conversion
Xenoestrogens from plastics and environment Liver problems 2-OHE1 to 16α-OHE1 ratio
Lower ratio is significantly increase in breast and possibly prostate cancer
Urine Testing Cruciferous vegetable product enhances to a more positive ratio
DIM induces certain P-450 enzymes in the liver to block the production of the toxic 16-OH estrogens and enhance the production of the beneficial 2-OH forms.
Glandular Advantages
Re energize your own glands Not guessing to doses Metabolized like food Has glandulars for hypothalamus, pituitary,
testes, prostate, ovaries and uterus Less expensive Problem of atrophy solved through
protomorphagen and adaptogens
GnRH, FHS, LH
GnRH secreted by hypothalamus LH and FSH released by anterior pituitary LH stimulates testosterone to be secreted
by Leydig cells in testes FSH stimulates spermatogenesis GH needed for spermatogenesis
Black Cohosh
Use: Menopausal symptoms (hot flashes, menstrual
migraine) Also: Arthritis pain, infertility
MOA: Estrogen-like effects that are exerted by an unknown
mechanism Preliminary research suggests that black cohosh
might: Act as a partial agonist at serotonin receptors including 5HT-
1A, 5HT-1D, and 5HT-7 receptors Increases osteoblast activity
Wild Yam
Contain diosgenin, Phytoestrogen (derived from plants) that can
be chemically converted into progesterone Contains saponins, diosgenin which we use to
make “natural progesterone in lab” However, thinks it has mild estrogenic activity
Grows mammary tissue in mice without ovary
Chaste Tree/Vitex
The flavonoids in chaste tree exert an effect similar to the hormone progesterone Plant contains no hormonal compounds Possess dopamine properties that inhibit prolactin and
increase progesterone Acts on the pituitary gland
normalizes the release of both follicle stimulating hormone (FSH) and luteinizing hormone (LH)
Used for PMS and Cramps
Other Herbals
Sage Contains natural estrogens Hot flashes and night sweats
St John’s Wort Many studies show it decreases depression Lowers anxiety
Testosterone
Distribution of hair Voice Baldness Protein and muscle development Thickens and helps bone grow RBC’s Increases metabolic rate 15%
Questions for Male Hormonal Issues
Do you need to urinate frequently, especially at night Strain when urinating Difficulty in starting urination or holding back urine Inability to urinate Weak or interrupted flow of urine Painful or burning urination Blood in the urine Painful ejaculation Pain in the lower back, hips or upper thighs Sex Drive Muscle decrease Fat around middle increase Sleep
Saw Palmetto Use:
Benign prostatic hyperplasia (BPH) Androgenetic alopecia Hypotonic neurogenic bladder Prostatitis/chronic pelvic pain syndrome
Demonstrates antiandrogenic, antiproliferative, and anti-inflammatory properties Noncompetitively inhibits 5 alpha-reductase types 1 and 2 and to
prevent the conversion of testosterone to dihydrotestosterone (DHT) May slow prostate cell proliferation by inhibiting fibroblast growth factor and
epidermal growth factor and stimulating apoptosis Laboratory evidence suggests that it inhibits lipoxygenase and cyclooxygenase
Laboratory evidence suggests that it inhibits lipoxygenase and cyclooxygenase
Anti-estrogen, antispasmodic, and alpha-adrenergic inhibitory proper
Stinging Nettles
Reported to inhibit sex hormone binding globulin which has an effect on the androgenic receptors of the prostatic cytosol
Inhibits the effects of estrogen May influence the binding of 5 alpha-
dihydrotestosterone with its receptors
Tribulus (Puncture vine)
Increases levels of testosterone, luteinizing hormone (LH), dehydroepiandrosterone (DHEA), and dihydrotestosterone
Aphrodisiac activity Tribulus might have anti-inflammatory activity as a
cyclooxygenase (COX)-2 inhibitor Tribulus might have anti-anginal activity
These effects are attributed to the protodioscin constituent It seems to dilate coronary arteries and improve coronary circulation It also may lower blood pressure by inhibiting angiotensin-converting
enzyme (ACE) Extracts from the fruit and leaves seem to have a diuretic effects,
which may explain the traditional use of puncture vine for kidney stones and other urinary problems
Vitamin D
Vitamin D2 ergocalciferol Vitamin D3 cholecalciferol
Vitamin D3 is produced in the skin of vertebrates after exposure to ultraviolet B light from the sun
In liver converted to prohormone calcidiol Converted into calcitriol the biologically active form of vitamin D, either in the
kidneys or by monocyte-macrophages in the immune system acts locally as a cytokine defending the body against microbial invaders
When synthesized in the kidneys, calcitriol circulates as a hormone regulating the concentration of calcium and phosphate in the bloodstream, promoting the healthy mineralization, growth and remodeling of bone
Modulates neuromuscular function Reduces inflammation Influences the action of many genes that regulate the proliferation
differentiation and apoptosis of cells
Pyridoxine (Vitamin B6)
Converted to pyridoxal 5'-phosphate (PLP) is the principal coenzyme form and has the most importance in human metabolism Co factor in 100 reactions in the body
Neurotransmitters: serotonin, dopamine, norepinephrine and gamma-aminobutyric acid (GABA)
Niacin (B3) Carpal Tunnel, tingling, pain ( increased with hypothyroidism) Helps for detoxification of hormones which may prevent
Breast CA Prostate CA
Vitamin C
The adrenal gland is among the organs with the highest concentration of vitamin C (as ascorbate)
Cofactor required both in catecholamine biosynthesis and in adrenal steroidogenesis
ACTH also causes vitamin C loss from adrenals
Women’s Balance
B6 Black current seed oil
Oil to decrease PG 2 and increase hormone Fish oil
PMS Chaste Tree
Iodine Cruciferous Vegetables
Men’s Balance
Andropause Protomorphagen containing testes, pituitary, thyroid
and adrenal Heart issues too: Wheat Germ Oil
Low Sex Drive and/or low muscle Add Tribulus Fish Oil Cruciferous Vegetables Saw Palmetto
REFERENCES• Sategna-Guidetti et.al. Autoimmune thyroid diseases and
coeliac disease. Eur J Gastroenterol Hepatol. 1999 Aug;11(8):939- 40.
• Kar, A. Panda, S. Bharti. S. Relative efficacy of three medicinalplant extracts in the alteration of thyroid hormone concentrations in male mice.
• http://www.naturaldatabase.com, Bladderwreck, last updated 3/17/2011
• http://www.naturaldatabase.com, Licorice, last updated 3/17/2011• http://www.naturaldatabase.com, Tribulus last updated 3/17/2011• Winston, David & Maimes, Steven. “Adaptogens: Herbs for Strength,
Stamina, and Stress Relief,” Healing Arts Press, 2007. • Robyn Klein."Allostasis Theory and Adaptogenic Plant Remedies" 2004 • Hobbs, Christopher "Medicinal mushrooms: The history, chemistry,
pharmacology and folk uses for modern times" Botanica Press, 1987. • http://www.naturaldatabase.com, Black Cohash, last updated
3/17/2011• http://www.naturaldatabase.com, Saw Palmetto, last updated
3/17/2011
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