Organism Gram Shape Capsule Aero-Type Enzymes Virulence Treatment Disease Other

Listeria monocytogenes + CoccobaccillusAerobic to

microaerophilic

CatalaseLysteriolysin O

Internalin A: E Cadherin on GI EpitheliumInternalin B: uptake into hepatocytes

PI-PLC; PC-PLC & Zn MetalloproteaseActA, PrfA

Ampicillin & Aminoglycoside (Gent)

Stillbirth (crosses placenta)Menigitis

SepsisEncephalitis

An STD!

Grows at 3º, survives saltMotility (tumbling) @ 25º-Hemolytic - ImmunityFacultative Intracellular

Epidemics in milk & cheese

Staphylococcus aureus +Ribotol

TA

Cocci-Clusters Most (75%) Facultative Aerobe

Catalase & EndonucleaseCoagulase

StaphylokinaseHyaluronidase

HemolysinExfoliatin Protease

Protein ALeukocidins & Toxin

Toxic Shock Syndrome ToxinEnterotoxin (SEA most common)

DOC = Vancomysin (for resistance)

Abscesses & Skin InfectionsScalded Skin Syndrome

Toxic ShockVomiting & Diarrhea (enterotoxin)Pneumonia & Acute Endocarditis

-HemolyticAcid from Mannitol

Staphylococcus epidermidis + Cocci-Clusters Facultative Aerobe CatalaseDOC = Methicillin & Oxacillin

Substitute = CephalosporinsIf resistant, use vancomycin

Shunt & Device Infections Novobiocin Sensitive

Staphylococcus saprophticus + Cocci-Clusters Facultative AerobeCatalaseUrease

DOC = Methicillin & OxacillinSubstitute = CephalosporinsIf resistant, use vancomycin

UTI in ♀

Corynebacterium diphtheriae +

Pleomorphic RodsOften “Club-Shaped”Chinese Charecters

Yes?K antigen

Aerobic Catalase & OxidaseDiphtheria ToxinProtein K Antigen

Polysaccharide O Antigen

Erythromycin (DOC)

Antitoxin AvailableVaccine Available (DPT)

Diphtheria

Forms PseudomembraneGrey on Tellurite PlateBabes-Ernst Granules

Toxin from Phage

Sterptococcus pyogenes(Group A Strep)

+Glycerol

TA

Cocci-ChainsYes

Hyaluronic AcidAerotolerant

(Microaerophillic?)

HemolysinStreptokinase

DNAseC5a Peptidase

Streptolysin O&S

M Protein, Finronectin Binding Proteins Collagen Binding Protein, SiC

Pyrogenic ExotoxinLipoteichoic Acid

Bacitracin sensitivePenicillin G/ErythromycinClindamycin (for exotoxin)

1st Generation Cephalosporins

Pharyngitis, Impetigo (Pyoderma)Toxic Shock Like Syndrome

Rheumatic Fever GlomerulonephritisNecrotizing Fasciitis

-Hemolytic

Streptococcus agalactiae(Group B Strep) + Cocci

YesSialic Acid

Aerotolerant C5a PeptidasePenicillin & Aminoglycoside

Neonatal Meningitis, PneumoniaNeonatal Spesis

UTI in ♀Invasive Disease

-HemolyticDeveloping vaccine

Streptococcus equisimilis(Group C Strep) + Cocci Aerotolerant

UTI, endocarditisbrain abcesses, puerperal sepsis

wound infections

-HemolyticImmunocompromised

Patients

Group D Strep + Cocci AerotolerantNosocomial Infection

UTISubacute Endocarditis

or-HemolyticEnterococci can grow in bile

& 6.5% NaCl

Viridans Strep(S. mitis & S. mutans) +

Dental CariesEndocarditis

Wound InfectionsSubacute Endocarditis

-HemolyticNormal Flora

Streptococcus pneumoniae + Diplococci YesAerotolerant

(Microaerophillic?)Pneumolysin

PspA1&2, Autolysin, Neurminidases, Hyalurinate Lyase, Choline Binding

Protein

OptichinPenicillin + VancomycinPenicillin, Amoxacillin

Macrolides, Quinolones, Doxycycline, Sulfa/Tri

Vaccines Available

MeningitisPneumonia

Otitis Media

-HemolyticSoluble in bile saltsVaccines Available

Haemophilus influenza - Rods/CoccobacilliYes

Ribotol Phosphate

Facultative Anaerobe ?

CatalaseIgA Protease

LOSOMP

(Type B = Rifampin &3rd Gen. Cephalosporins)

(NTHi = augmentin, sulfa/tri, macrolides, cephalosporins)

Vaccine Available (DPT)

Type B = Meningitis, Epiglotitis, Arthritis, sepsis & pneumonia)

(NTHi = OM & Sinusitis,)

Unique CapsuleGrows on CAP w/ V & XFever is disease hallmark

Organism Gram Shape Capsule Aero-Type Enzymes Virulence Treatment Disease Other

Neisseria meningitidis - DiplococciYes

Sialic AcidFacultative Anaerobe

CatalaseOxidase

IgA Protease

LOS & OMPPili

Transferrin Binding ProteinCapsule is critical to virulence!

IV Ampicillin3rd Gen. Cephalosporin

Vancomycin

Vaccines Available

MeningitisFulminant Sepsis

Non-motileCan utilize maltose

Bordatella pertussis - Coccobacilli Aerobe

Filamentous HemagglutininPertussis Toxin

Soluble adenylcyclaseTracheal cytotoxin

None – supportive only

Vaccines Available

Whooping CoughBacteremia & Pneumonia rare

3 Phases (CPC) Catarrhal, Paroxysmal

Convalescent Lymphocytosis

Mycoplasma pneumoniaNo wall

PleomorphicPrefer

AerobicConditions

Cytadhesion ProteinTetracycline

Erythromycin & ClarithromycinWaslking Pneumonia

Cause NeutropeniaCold Agglutinins

Very SmallQuick Doubling Time

Mycoplasma hominisNo wall

Pleomorphic Pos-Partum & Abortion FeverErythromycin Resistant

Ureaplasma urealyticumNo wall

PleomorphicPrefer

AerobicConditions

Urealase Tetracycline Urethritis Causes alkaline urine

Legionella pneumophila - Rod shaped? Aerobic

MetalloprotesaseAcid Phosphatase

Lipase, Phospholipase ANuclease

Type IV PilusType II Secretion system

Erythromycin (DOC)Rifampin

Tetracycline

Legionnaire’s PneumoniaWatery Diarrhea

Pontiac Fever

Motile (flagellated)Facultative Intracellular

Use amoeba as hostGrows at high temps

Chlamydiae pneumonia -(No wall)

Cocci?(Rounded)

Aerobic? Type III Secretion SystemErythromycinTetracycline

Walking PneumoniaAtherosclerosis?

Obligate IntraceullularDimorphic: EB & RB

Use amoebaGlycogen Inclusions

Chlamydiae psittaci -(No wall)

Cocci?(Rounded)

Aerobic?ErythromycinTetracycline

Psittacosis pneumonia(splenomegaly & hepatomegaly)

Obligate IntraceullularDimorphic: EB & RB

Use amoebaFrom Birds

Shigella - RodShiga Toxin

Ruffles!3rd Generation Cephalosporins

& Quinonlones

Shigellosis(diarrhea w/blood,pus,mucus)

Hemolytic Uremic Syndrome (HUS)Cramps,Pain,Fever,Malaise

Non Motile & Lactose - Facultative IntracellularAcid Resistant-Low # IDCaspase 1(ICE) activation

Antibiotic Resistance

Escherichia coli (ETEC) - Rod Yes?

Type I PiliColonization Factors = CFA I,II & III

Bundle Forming PilusHeat Labile Toxin (LT)Heat Stable Toxin (ST)

Sulfa/Tri’s or QuinolonesTraveler;s Diarrhea(Watery Diarrhea)

Vomiting

Motile (Flagella); Lactose +

ST,LT, CFA on plasmidNo feverImmunity

Leading COD in children

Escherichia coli (EPEC) - Rod Yes?

Bundle Forming PilusLocus of enterocyte effacement (LEE)Translocated Intimin Receptor (TIR)

No Toxins!

Sulfa/Tri’s or QuinolonesWatery Diarrhea w/ fever

Chronic Diarrhea in children

Motile (Flagella); Lactose +LEE induced by quorumLEE = Intimin & Contact

Secretion SystemIntracellular Invasion?

Escherichia coli (STEC/EHEC) - Rod Yes?

LEE (with intimin)Translocated Intimin Receptor (TIR)

Shiga Like Toxin (SLT)

Watery→Bloody DiarrheaHemolytic Uremic Syndrome (HUS)

Motile (Flagella); Lactose +SLT on Phage

Serotype O157:H7 commonbeef (90% contaminated)

Raw Milk

Escherichia coli (EIEC) - Rod Yes? Toxin similar to Shiga Toxin Sulfa/Tri’s or Quinolones Less severe type of Shigellosis(diarrhea w/blood,pus,mucus)

Motile (Flagella); Lactose +Close relative of Shigella

Organism Gram Shape Capsule Aero-Type Enzymes Virulence Treatment Disease Other

Escherichia coli (EAEC) - Rod Yes? Hemolysin

Thin PiliShiga Like Toxin (EAST)

PET Serine Protease

Watery DiarrheaMucus Gel on intestinal mucosaPersistent Diarrhea in children

Motile (Flagella); Lactose +Serine Protease on Plasmid

Escherichia coli (UPEC)Yes

Most P-sacSome Protein

HemolysinSiderophores (ex. aerobactin)

Cytotoxin (break down epithelium) P Fimbrae (pili)

85% Community Acquired UTIsAcsending or Descending Septicemia

Motile (Flagella); Lactose +Plasmids

Campylobacter jejuni - Curved RodYes

PolysaccharideMicroaerophillic

PiliCytolethal Distending ToxinsLPS resembles ganglioside

ErythromycinTetracycline

Aminoglycosides

Lower abdominal painDiarrhea w/ blood & pus

FeverGuilian-Barre Syndrome (GBS)

Autoimmune Disease

Motile - FlagellaChicken Water & Milk

Causes 30% inf. DiarrheaIntracellular InvasionPenicillin Resistant

Campylobacter fetus - Curved Rod Systemic gastroenteritisMotile - Flagella

Helicobacter pylori -Curved to spiral rods

&Cocci

Microaerophilic Urease

Adhesins (BabA, LPS?)Neutrophil activating Protein (NAP

Vacuolating Protein (VacA)Contact Secretion

(effacement, pedestal, MAP Kinase)

Two weeks of 2 antibiotics & antacid

Gastritis & Ulcers (Type 1 only)Adenocarcinoma & Lymphoma

Rods = flagella; Cocci = notInfected in childhood

Type 1 = CagA+, VacA+

Type 2 – CagA-, VacA-

ELISA & Breath Tests

Vibrio cholerae - Curved RodSome

(ex. El Tor – O:139)

Oxidase

Toxin Co-Regulated Pilus (TCP) from VPI

Cholera Toxin (CT) from CTXZonula Occludens Toxin

Metallo ProteaseAcf, Ace, Vac

Tetracycline

Vaccine Available (ineffective)

Vomiting & Watery Diarrhea“Rice Water Diarrhea”

Motile - FlagellaAcid Sensitive

Raw crabs & shrimpTCP & CT from 2 Phages

Immunity

Vibrio vulnificus - Curved Rod Immediate antibioticsSerious Septicemia (50% mortality)

Fever, Chills, HypotensionWound Infections

Motile - FlagellaHalophillic – Requires salt

Raw OystersIntracellular Invasion

Vibrio parahemolyticus - Curved Rod None – self limitingCholera Like - Vomiting & Diarrhea

(Less severe)Possible Septicemia

Motile - FlagellaRaw fish, shellfish, oysters

Salmonella typhimurium - Rod

2 Type 3 Secretion SystemsSPI-1 = Epithelial Cell Invasion

SPI-2 = Blocks NADPH Oxidase KillingRuffles!

AmpicillinGastroenteritis

Vomiting & Diarrhea (bloody, No WBCs!)Bacteremia in immunocomprimised

Motile - FlagellaChickens & Raw Eggs

Produce H2S, Bile ResistantAcid Tolerant

Facultative Intracellular

Salmonella typhi & paratyphi - Rod

Invades & Kills M Cells; Invades Ms

Ciprofloxacin (DOC)AmpicillinSulfa/Tri’s

Vaccine Available

1st Fever & Headache2nd Rash on Abdomen & Chest

3rd Bacteremia w/ multiple organs4th Hemorrhaging Peyer’s Patches

Colonizes gallbader – stonesCystic Fibrosis CarriersFacultative IntracellularMacrophage Replication

Yersinia enterocolitica - Rod Urease at 37º, but not at 25º

Adhesins: InvA, Ail, PH 6 Antigen, YadAInvades M Cells

YopM = anti-inflammatoryOther Yops = induce apoptosis, NFKB, etc

Heat Stable Toxin (similar to E. coli)

Tetracycline, Chloramphenicol(only for systemic infection)

Fever, Pain, Diarrhea in childrenAdenopathy in older children

Autoimune disease with HLA-B27Septicemia

Motile @ 37º, Grows @ 4ºScandanavia – Milk & Food

Facultative Intracellular

Yersinia pseudotuberculosis - RodTetracycline, Chloramphenicol

(only for systemic infection)Lymphadenitis

Mimics appendicitis

Facultative IntracellularSimilar to Ye, but more invasive & no diarrhea

Klebsiella pneumoniae - Rod YesAbundent Capsule

PiliHeat Stable/Labile Toxins (like E. Coli)

3rd Generation Cephalosporins(Ceftriaxone & Cefotaxime =

DOC)

Burn InfectionsUTI, Meningitis, bacteremia, wound

infections

Non- Motile; Lactose +-Lactamase (R Plasmid)

Resist Amp & Carbenicillin

Organism Gram Shape Capsule Aero-Type Enzymes Virulence Treatment Disease Other

Enterobacter cloacae - Rod Yes Heat Stable/Labile Toxins (like E. Coli)3rd Generation CephalosporinsAnti-pseudomonal penicillin

Aminoglycoside

Motile-Flagella, Lactose +Most common hospital

isolate-Lactamase (inducible)

Serratia - Rod Extracellular DNAseNosocomial: pneumonia, septicemia, UTI,

& woundIV Drug: endocarditis & osteomyelitis

Prodigiosin – Red on PlateColistin, Cephalothin, anti-

Pseud & Amikacin ResistantMotile-Flagella?, Lactose

+/--Lactamase

Citrobacter - Rod Yes?Vi Antigen (similar to S. typhi)

OMPs (on virulent strains)Heat Stable Toxin (ST)

Aminoglycosides, Tetracycline, Chloramphenicol

UTI & RTI in debilitated patientsNeonatal meningitis & abscesses

Citrate is sole energy sourceH2S productionMotile-Flagella

-Lactamase (resistant ones)

Proteus mirabilis - Rod

Urease (Ni Metalloprotease)

Phenylalanine DeaminaseHemolysin

FimbraeNosocomial Infections

UTIs

Indole + (not P. mirabilis)Motile – Flagella

Gent/Tobramycin Resistant-Lactamase (inducible)

H2S production

Providencia - Rod BacteremiaNursing Homes Catheters-Lactamase (inducible)

Morganella - RodOpportunistic Pathogen-

Lactamase (inducible)

Pseudomonas - RodYes

Alginate

Aerobic& NO3

RespirationOxidase

Pyanocyanin & PyochelinAdhesins

Elastase (LasA & B)Phospholipase C/rhamnolipid

Dermatitis, Burn Infections, Eye Infections, Lung Infections,

Nosocomial septicemia, Nosocomial UTI

FluoroquinolonesAminoglycosides

Carbapenems (Imipenem)4th Cephalosporins

Motile – FlagellaVery Antibiotic Resistant

Fruity Smelling & BiofilmsProblem with CF Patients

-Lactamase

Mycobacterium tuberculiAcid Fast

Rod Aerobic Cord Factor

Preventative = INH (9), Rif (4)Treatment: 1) INH (6)

2) Rif (6) 3) Pyrazinamide (2)4) Ethambutol or Streptomycin

Vaccine Available!

Tuberculosis:Primary – lower lobes (Gohn Complex)Reactivation – Apical lobes (cavitary)

Miliary - extrapulmonary

Latent vs. Active InfectionPPD = 5,10,20 mm

Use DOT to give drugINH Resistance in KY

Facultative Intracellular

Mycobacterium lepraeAcidFast

Rod Aerobic Cord Factor Dapsone & Rifampin

Tuberculoid (Pauci-Bacillary)Lepromatous (Multibacillary)

Severe DisfigurementClaw Hand & Drop Foot (nerve)

Doesn’t grow in mediaObligate IntracellularInfects nerve tissue!

Colonize Liver & Spleen (with no destruction)

Mycobacterium avium & intracellulare

AcidFast

Rod AerobicLPS (not very inflammatory)

Heat Shock ProteinType III Secretion

VariableFever, Fatigue & Weight LossMultiple Organ Involvement

Diffuse Interstitial InfiltrateAcquired from environment

Neisseria gonorrhea -Cocci

Kidney Bean Diplococcus

Sialic Acid(If Disseminated)

AerobicOxidase

IgA Protease

OMP1 (Endometrial Lutropin Receptor)Opa Proteins PII (Pyruvate Kinase)Rmp PIII (Invade Epithelial Cells)LOS, Peptidoglycan & Pili (CD46)

3rd Generation Cephalosporins (Ceftriaxone)

Most are Pennicillin Resistant

Mouth: Pharyngitis & AdenitisAnal: Irritation, Discharge, Bleeding

Male: Urethritis, Discharge, SpreadingFemale: Cervicitis, PID, Endometriosis

Disseminated: Rash & Arthritis

Facultative IntracellularCan’t Utilize Maltose

IgA Protease cleaves Lamp 1

If disseminated, no virulence Inflammation & Destruction

Chlamydia trachomatis -(No wall)

Cocci?(Rounded)

Heat Shock Protein Erythromycin & Tetracycline

Trachoma (A-C): #1 cause of blindnessGU Infections (D-K): #1 bacterial STD

Causes Urethritis & CervicitisLymphogranuloma Venereum (L1-3)

Inclusion Conjunctivitis (D-K): pneumonia

Obligate IntracellularDimorphic: EB & RB

Inclusions get sphingolipids from Golgi-stops

endocytosis

Treponema pallidum No Stain Spirochete

Very FewOMPs bind lamini, collagen, fibronectin

Tromp112 Tpr’s – unknown fxn

Penicillin G

1º - Chancre (no pain & lymphadenopathy)2º - Disseminated chancres & flu symptoms

Latent – Assymptomatic but infectious3º - Neurologic Symptoms = PARESISLate Benign (gummas) & Congenital

2 Periplasmic FlagellaeCan’t culture – rabbit testis

Jarisch-Herxheimer Rxn

Organism Gram Shape Capsule Aero-Type Enzymes Virulence Treatment Disease Other

Treponema denticolaNo Stain Spirochete Protease Dentilysin Periodontal Disease 2 Periplasmic Flagellae

Trep3onema vincentii No Stain SpirocheteVincent’s Angina (Trench Mouth)

Periodontal Disease2 Periplasmic FlagellaeAKA Borrelia vincentii

Leptospira interrogansOral Laactams or

Tetracyclines

Infects Kidneys and Liver90% have flu symptoms

10% have Weil’s Syndrome - Icteric

Shed in animal urinePenetrates intact skin

Often in water sources? Shape

Clostridium perfringens + Rod Aerotolerant toxin (lecithinase C)

Type C Toxin?None

MyonecrosisAnaerobic Cellulitis

Clostridial Gastroenteritis (fever, no vomiting, lasts longer, starts

later)

Double layered HemolysisInsoluble H2S,SO2,CH4

Rare to none sporesToxins are heat labile

Clostridium dificile + Rod Anaerobic Toxin A & B Discontinue AntibioticsAntibiotic Associated Colitis

Pseudomembranous EnterocolitisInsoluble H2S,SO2,CH4

Clostridium botulinum + Rod AnaerobicBotulinum Toxin (neurotoxin)

blocks Ach release)Antitoxin Available

Nausea & vomiting w/ no diarrhea or fever!Weakness, Dizziness, Cranial Nerve Palsy

Death from respiratory paralysisFloppy Baby Syndrome

Wound Botulism

Insoluble H2S,SO2,CH4

Most stable of all sporesToxin is heat labile

Mortality of Type E>A>B

Clostridium tetani + Rod Anaerobic Tetanospasmin (neurotoxin)

Penicillin or Metroinidizole

Antitoxin AvailableVaccine Available (DPT)

Tetanus NeonatorumTetanus

(opistothonos, arms flexed, legs extended)

Insoluble H2S,SO2,CH4

Spores are ubiquitous

Prevotella melaninogenica - Rod

Bacteroides fragiles - Rod Yes95% of normal fecal flora

Secretes -Lactamase

Rickettsia ricketsii - Rod Yes OmpATetracycline

Chloramphenicol

Rocky Mountain Spotted FeverStarts with Flu Symptoms

Rash starts at extremities→trunkLater non-blanching rash w/ petichiae

Death from organ failure in a week

Obligate IntracellularFrom Tick Bites

Rickettsia typhi - RodEndemic Typhus (Flea Borne)Flu like symptoms with rash

Pulmonary Involvement is common

Obligate IntracellularFlea bite or inhaled fecesDon’t use Sulfas! →Death

Rickettsia prowazekii - Rod Vaccine Available

Epidemic TyphusRash starts at trunk→extremities

CNS abnormalities (stupor) & CoughBrill-Zinsser

Obligate IntracellularBody Louse (Bad Hygeine)

Flying Squirrels

Rickettsia akari - Rod Rickettsialpox (Flu & Rash)Obligate Intracellular

Mouse Bites

Organism Gram Shape Capsule Aero-Type Enzymes Virulence Treatment Disease Other

Orietsia tsutsugamushi - Rod Scrub Typhus (Macropapular Rash)Obligate Intracellular

Chiggers

Ehrlichia chaffiensisHuman Monocytic Ehrlichiosis

Flu Initially, rash rareLeukopenia & Thrombopenia

Lonestar Tick

Anaplasma phagocytophila

Human Granulocytic AnaplasmosisHuman Monocytic Ehrlichiosis

Flu Initially, rash rareLeukopenia & ThrombopeniaMorulae in leukocyte common

Ixodes Tick

Coxiella burnetti Vaccine Available

Q FeverFlu-Like Illness

Cough & Pneumonia commonThrombocytopenia common

Death is rare

Tick bite or spores (usually)

Borrelia burgdorferi No Stain SpirocheteSurface Proteins: DbpA, DbpB, p47,

Erp Proteins, H/FHL-1 (CRASPs), VIsEBmpA & OspC

Oral Laactams or Tetracyclines

Vaccine NOT Available - 2002

Lyme Disease: Flu Like SymptomsErythema Migrans (Rash) = DiagnosticAlso Bell’s Palsy Arthritis & Cardiac

Problems

Ixodes Tick (nymphs) Bite Antibodies cross react with

treponemes

Borrrelia hermsii No Stain Spirochete Variable Membrane ProteinTick Born Relapsing FeverFever (periodic) & Malaise

Also caused by: B parkerii & duttonii

Ornithodoros TickRat Infested Shelters

Borrrelia recurrentis No Stain SpirocheteLouse Born Relapsing FeverFever (periodic) & Malaise

Higher fatality rate than TBRFCrushed Body Louse

Bacillus anthracis + RodYes

PolypeptideAerobic

Toxic Troika:1) Protective

2) Edema Factor (EF) – activates cAMP3) Lethal Factor (LF) –no cytokine release

CiprofloxacinDoxycycline

Penicillin

Vaccine (toxin) Available

Anthrax: Malignant Pustule – black eschar

Inhalation - mediastinitis – no pneumoniaEnteritis – need lots of spores for death

IV – heroin users

Large Rods

Erysipolothrix rhusiopathiae + Rod Penicillin

ErysiploidCutaneous infection from abrasionCan cause arthritis, meningitis &

endocarditis

From Meat & Fish

Yersinia pestis - Rod Yes Antigen expressed only at 37º C

Streptomycin (DOC)Tetracycline

Vaccine Available

Bubonic Plague – gangrene & buboPneumonic Plague – high fever,

pneumonia, hemoptysis – also septic symtoms

Bipolar Staining (safety pin)

Francisella tularensis - Cocci (young)Rod (older)

StreptomycinDoxycycline or Cipro =

Prophylaxis

Vaccine Available

TularemiaUlceroglandular Form – bubo from bug bite

Typhoidal – eating raw rabbit meatOcculoglandular – rubbing eyesInhalation – pneumonia (rare)

Facultative IntracellularVaccine Available

Brucella melitensis - Coccobacillus Brucellergen Tetracycline or Rifampin Brucellosis Goats & Sheep

Brucella abortus - Coccobacillus Brucellergen Tetracycline or Rifampin Brucellosis Cows

Organism Gram Shape Capsule Aero-Type Enzymes Virulence Treatment Disease Other

Brucella suis - Coccobacillus Brucellergen Tetracycline or Rifampin Brucellosis Pigs

Streptobacillus moniliformis - Pleomorphic PenicillinRat Bite Fever

Bite heals→3-10 days later: inflammation, adenitis & fever; acute arthritis

More common of 2 Rat Bite Fevers

Spirillum minus - Spiral Shaped PenicillinRat Bite Fever

Bite heals→1-3 weeks later chancre like ulcer, adenitis, relapsing fever

Polar FlagellaSoduko Fever

Bartonella henselae

Cat Scratch FeverPapule at scratch site, lymphadenopathy,

malaise & low grade feverBacillary Angiomatosis in AIDS patients

Pasteurella multocida - Coccobacillus

Cat Bite FeverLymphadenitis, septisemia

Meningitis, Endocarditis, Osteomyelitis rare