Avian Tumor
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AVIAN TUMOR
Prepared By
DEWI RATIH AGUNGPRIYONO, DVM, PhD
Division of PathologyDepartment of Veterinary Clinic, Reproduction and Pathologyp y , p gyFaculty of Veterinary Medicine, Bogor Agricultural University
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D Diseases causing avian tumor :
1. Marek (MD)( )
2 Avian Leukosis (AL)2. Avian Leukosis (AL)
3 Reticul end theli sis (RE)3. Reticuloendotheliosis (RE)
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ETIOLOGYMDV ALV REVMDV ALV REV
α Herpes virus Retrovirusα Retrovirusp RetrovirusSerotype 1 oncogenicSerotype 2 non-
oncogenic A i L k i Vi
Avian Sarcoma Virus
Sub grup A
oncogenicSerotype 3 HVT non-
oncogenic
Avian Leukosis Virus
Sub grup Boncogenic
Sub grup J
DNA Virus RNA Virus RNA VirusDNA Virus RNA Virus RNA Virus
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TYPE OF TUMOR CELLSMD ALV REV
Lymphoma LymphomaSarcoma Lymphoma (mononuclear pleiomorphic cells :
LymphomaTumor of blood vessel, tumor of loose connective tissue
uniform lymphoblast p p
lymphocytes, lymphoblast, plasma
connective tissue, epithelial tumor
tumor cells, immature and mature
cell, macrophage) Lymphoma and Leukosis
uniform lymphoblast tumor cells, erythroblast erythroblast, myeloblast, myelocyte
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TYPE OF TUMOR CELLSMD ALV REV
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TRANSMISSIONMD ALV REV
Horizontal Horizontal, Vertical
Horizontal, Vertical Direct Contact Direct Contact
Indirect : Inhalation
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Gross Pathology MD ALV REV
Nerve : enlarged Nerve : enlargedg
Skin : feather follicle Viscera : visceral tumor Viscera : visceral
tumor Viscera : visceral tumorSkin : feather follicle
tumorEye : greyy g y
8 – 10 weeks > 24 weeks > 24 weeks
Not all tumor cases could be observed grossly !
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Gross Pathology gy
Grey Eye (right)lymphoid infiltration of iris that causes white discoloration. The pupil is often irregular (as shown here) and does not respond to ) pchanges of light. A normal eye is on the left.
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Visceral Tumor (liver)Visceral Tumor (liver)
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Gross Pathology
b /111/02patoipb U/111/02
Visceral Tumor(liver and spleen)( p )
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Gross Pathology
Visceral Tumor (spleen)
patoipb U/30/01
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Thickened proventricular wallGross Pathology
T i l (h ti)Tumor viseral (hati)patoipb U/60/01
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Gross Pathology Gross Pathology
patoipb U/30/01
Visceral Tumor (lung)
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Gross Pathology
Visceral Tumor (kidney)
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Gross Pathology gy
Nerve Tumor (nervus Brachialis)
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Gross Pathology
Nerve Tumor (nervus Ischiadicus)
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Gross Pathology
The dorsal root ganglia from bird with Marek's disease
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Gross Pathology
Skin Tumor / Feather Follicle Tumor
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Gross Pathology gy
Skin Tumor / Feather Follicle Tumor
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Gross Pathology gy
large subcutaneous lymphomas may be observed throughout the body (shown here in the leg on the left). A normal leg is shown on the right for comparison
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Gross Pathology
os sternum tumor
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Gross Pathology Gross Pathology
Costae Tumor
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G P th l Gross Pathology
B F b i i TBursa Fabricious Tumor
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Gross Pathology
Liver Hemangioma
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Microscopic Lesion MD ALV REV
Nerve : infiltration Nerve : infiltration of pleiomorph lymphocyte, demyelinization,
mature and immature lymphoblast
Schwann cells proliferationB i i l Brain : perivascular accumulation lymphocyte pleiomorph lymphocyte pleiomorph, spread to neuropil, necrotizing malaciag
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Histopathology p gy
N m lNormal
patoipb S/30/02Nerve Tumor
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Histopathology p gy
Demyelinization
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Histopatology p gy
tumor cells perivascular cuffing
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Histopathology p gy
patoipb S/30/02Malacia
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Histopathology MD ALV REV
Viscera : interstitial i filt ti f l i h
Visceral : interstitial i filt ti f
Visceral : interstitial i filt ti f infiltration of pleiomorph
lymphocytes tumor cellsinfiltration of lymphoblast tumor cells in many visceral
infiltration of lymphoblast tumor cells in many visceral
Skin : accumulation of pleiomorph lymphocyte
cells in many visceral organ
cells in many visceralorgan
pleiomorph lymphocyte at feather follicle epitheliumBone Marrow : multifocal accumulation l h t l i h
Bone Marrow : diffuse accumulation limfoblast tumor cellslymphocyte pleiomorph limfoblast tumor cells
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Histopathology
Liver Tumor
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Histopathology
interstitial ovary tumor cells
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Histopathology
Feather Follicle Tumor
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Histopathology MD ALV REV
Lymphoreticular : Lymphoreticular : lymphoid cells cytolisis → follicle depletion; Bursal interfollikular
Proliferation of lymphoblast tumor cells at spleen (red Bursal interfollikular
pleiomorph lymphocyte tumor cells infiltration
cells at spleen (red pulp) and bursa (intrafollicullar); tumor cells infiltration (intrafollicullar);
Vascular : Atherosclerosis
Vascular : Circulation of proliferated tumor cells (leukosis)cells (leukosis)
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Histopathology
Interfollicular Bursa Fabricious Tumor, Lymphoid Follicle Atrophy
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Histopathology
Interfollicular Bursa Fabricious Tumor
Intrafollicular Bursa Fabricious Tumor
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Histopathology MD ALV REV
antigen Detection of antigen Detection of antigen Detection of gsurface
MATSA 5-40% MATSA negatif MATSA negatif
gsurface
gsurface
Ig M < 5 %Sel B 3-25%Sel T 60-90%
MATSA negatif Ig M 91-99 %Sel B 91-99%Sel T rare
MATSA negatif Ig M ?Sel B rareSel T plentySel T 60 90% Sel T rare Sel T plenty
MATSA : Marek’s Disease Associated Tumor Surface Antigen
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Clinical Sign
MD ALV REVTransient Paralysis Sub clinic Sub clinicy
(Late clinical onset) (Late clinical onset)
patoipb U/116/02
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ALV Infected Male
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PreventionMD ALV REV
Vaccination Biosecurity BiosecurityBiosecurity
yBreeder control
y
(Culling positive parents)Breeder control
(Culling positive parents)
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Non-specific Lesion
Egg Yolk Peritonitis
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Non-Spesific Lesion
interstitial ovary tumor cells
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Non-spesific Lesion
patoipb U/111/02
Necrotic Enteritis
patoipb U/111/02
Necrotic Enteritis
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Non Spesific Lesion
T ll ithi i t ti l l i iTumor cells within intestinal lamina propria