AU5800 hardware, features and comparisons to other AU models

of 45Beckman Coulter Professional Development

AU5800 hardware, features and comparisons to other AU models

5800 Comparisons Rev. A (August 2014)

5800 Comparisons Rev. A (August 2014)

Table of Contents

Introduction……………………………………………………………………. 3

Terminology and Configuration……………………………………………… 5

Throughput…………………………………………………………………….. 6

New Hardware Features……………………………………………………... 9

Maintenance Improvements…………………………………………………. 18

Part Numbers………………………………………………………………….. 19

New ISE Features…………………………………………………………….. 20

New Software Features from AU480/AU680………………………………. 21

Software Changes……………………………………………………………. 30

New Software Features from AU2700/AU5400…………………………… 36


Introduction

AU5800 Overview:

• Describes the hardware, ISE, and software differences between the AU5800 and the AU480/AU680, and AU2700/AU5400

• Provides an overview of the AU5800 new features and benefits

5800 Comparisons Rev. A (August 2014) of 45

Beckman Coulter Professional Development

Integrated Data Workstation & Auto Repeat Unit• Less footprint• Improved workflow and results processing

New Style for AU5800

Newly Designed Covers and Body Style• Ergonomic design to improve everyday user tasks



Terminology and Configuration

Units Single ISE Dual ISE» AU5810 AU5811 AU5812» AU5820 AU5821 AU5822» AU5830 AU5831 AU5832» AU5840 AU5841 AU5842

» Unit Configuration:– AAAA: A test is on unit 1, 2, 3, and 4

– ABCD: A test is only on unit 1, 2, 3, or 4

– AABB: Configuration is the most efficient (variance for low volume tests)

– Racks can bypass a unit for throughput based on test requisition and unit configuration



Scalability and Throughput4 Scalable Models to Meet High and Ultra-high Volume Testing

AU5840: 8000 tests/hr, 9800 tests/hr with dual ISE






AU2700: 1600 tests/hr, 2133 tests/hr with single ISE



Enhanced Performance

Higher throughput• 2,000 photometric tests per hour

per analytical unit vs. 1,600 photometric tests per hour per analytical unit on the AU2700/AU5400:

25% increase over AU2700/AU5400

• 3.6 second cycle time vs. 4.5 second cycle time on the AU2700/AU5400



Affects on Throughput

Inner/Outer Wheel Assignment• Parameters > Common Test

• Parameters > Test Name

Unit Assignment• Parameters > Common Test

• Parameters > Group of Tests

Requisitions• Individual tests vs. profiles

• Number of tests requisitioned per sample affects sample throughput

Operators• Move a test to a different unit for

troubleshooting

• Program a new test on system

Default profiles5800 Comparisons Rev. A (August 2014)


New Hardware Features

Rack Collection Trays (2): each holds 20 racks or 200 samples Rear

Return LanePrimary LaneBypass Lane

DualSample Probes

RackBuffer Unit: Auto Repeat

ISE

Rack Loading Trays (2): each holds 20 racks or 200 samples

R2: 54 positions

R1: 54 positions

Front

Priority Rack Loading Unit

5800 Comparisons Rev. A (August 2014) of 45Beckman Coulter Professional Development

New Hardware FeaturesRack Trays

Rack Set Trays and Rack Collection Trays • Easy loading of up to 20 racks (200

samples) per tray

• Rack set unit accommodates two trays (400 total samples), and rack collection unit accommodates two trays (400 total samples)

• Trays can be removed from analyzer to transport racks

• All four trays are interchangeable



New Hardware Features Priority Rack Loading Unit

Priority Rack Loading Unit• Load emergency racks (red) or routine

racks (white) on 2 priority loading positions and press Start

• Racks are moved from the rack buffer unit as a priority over racks loaded on the rack set trays, and processed on the bypass lane for faster turnaround time

If two racks are placed on the priority rack loading unit, the rack in position one is processed first.

• Priority for QC and Calibrator racks can be configured



New Hardware Features Rack Buffer Unit / Auto Repeat

Rack Buffer Unit / Auto Repeat• A separate Auto Repeat unit is not

required. (AU5400 required a separate Auto Repeat unit)Less costLess space required

• Repeat racks are transferred to the bypass lane for priority repeat analysis.



New Hardware FeaturesReagent Compartments

• Larger Capacity Reagent Compartments

AU5800: 54 reagent positions

AU2700/AU5400: 48 reagent positions per unit

• Cleaning solution bottles for contamination prevention are located outside of the R1 and R2 refrigerators for additional onboard reagent positions from AU2700/AU5400

R1: positions 57. CLN-1, 58. CLN-2, 59. CLN-1, and 60. CLN-2


• Diluent bottles are located by the R1 refrigerator.

R1: positions 55. Diluent/W2 and 56. Diluent/W2



Programmable and Onboard Tests

Increased number of programmable tests:

AU5800: 120

AU5400: 99

AU2700: 99

Increased number of onboard assays:

AU5830 and AU5840: 120

AU5820: 111

AU5810: 57

AU5421 and AU5431: 99

AU2700: 51



Reagent Bottles

• 15 mL, 30 mL and 60 mL bottle reagent empty/dead volume is the same as other AU systems:

15 mL 400 uL30 mL 1.0 mL60 mL 1.0 mL

• 120 mL and 180 mL bottles:

The current 120 and 180 mL (5400/2700) bottles can not be used on the AU5800 because bubbles and level detection errors are produced due to the rotation speed of the R1 and R2 compartments

The 180 mL bottles are re-designed for 5800, 5400 and 2700 and can be used following a software update (specific for 180 mL bottle usage) performed by BCI personnel


Wash Solution

• The diluted wash solution is 1% +/- 0.5%.

• The total consumption of wash solution (concentrated) is approximately 130 mL per hour per unit.

5800 Comparisons Rev. A (August 2014)Page 1 6 of 45


Inner/Outer Wheel and Odd/Even Components

AU5800 Odd (S1, R11, R21) = Inner wheel Even (S2, R12, R22) = Outer wheel

AU2700/AU5400 Odd (S1, R11, R21) = Outer wheel Even (S2, R12, R22) = Inner wheel



Maintenance Improvements

AU2700/AU5400: If a cuvette fails the Weekly Photocal

(cuvette check), the entire 30 minuteprocedure must be repeated

No flag to alert operators a test was run on a defective cuvette

AU5800: If a cuvette fails the Weekly Photocal

(cuvette check), the individual cuvette can be re-checked in 8minutes. Significant operator and analyzer time savings

Photometer check included in the Photocal procedure: save approximately 5 minutes

A new “Wa” flag indicates a test was run on a cuvette that failed the photocal



Part Numbers

AU5800:• Lamp: MU8550

• R probe: MU8581

• S probe: MU9934

• Spiral mix bar: MU8554

• L-shape mix bar: MU8555

• Cuvette: MU8552 (4x5 mm, 80 to 287 uL)

AU480/AU680• Lamp: MU9888

• R probe: MU9958

• S probe: MU9934



• AU680 Cuvette: ZM0634 (5x6 mm, 120 to 420 uL)

• AU480 Cuvette: MU8465 (5x5 mm, 90 to 350 uL)

AU2700/AU5400

• Lamp: ZM0635

• R probe: MU9958

• S1 probe: MU8206, S2 probe: MU8207



• Cuvette: ZM0634 (5x6 mm, 120 to 420 uL)



New ISE Features:

• Ability to calibrate the ISE in Measure mode

• Ability to print the ISE calibration results in a list

• Ability to calibrate the ISE and perform a reagent check at the same time

• Decrease start up time



New Software Features from AU480/AU680 Sample Status

• Order: Displays the time a sample

goes past the cup detector

• Status: Displays “In Process” while the

sample is in process Displays “Done” when the

sample is complete

• Results: Displays the time of sample

(RB, cal, QC, and patient) completion while the sample is in process

Displays a white box (no text) when the sample is complete without an error flag

Displays “Error” in red when the sample is complete with a flag on a test performed on the sample

New: RB, Cal, and QC samples can be selected and viewed in the Detail menu.



New Software Features from AU480/AU680 Sample Status

• The ability to search and display a sample by sample ID using Search (F2)

• Direct menu access to Analyzer Status, Sample Manager, Reaction Monitor, and ISE Maintenance menus

• Direct access makes software more user-friendly



New Software Features from AU480/AU680 Sample Status Detail

• Displays patient test results as they complete realtime

• Displays partial sample results and time to completion for each test

• “Results”: Displays the time of sample completion

• A test with an error flag displays in red. Select the test to display a description and help for the error in <Contents of Error> Operator time-savings: do

not have to access User’s Guide for flag help and corrective actions



New Software Features from AU480/AU680 Realtime Display

• The ability to search and display a sample by sample ID using Search (F2)

• Direct menu access to Analyzer Status, Sample Manager, Reaction Monitor, and ISE Maintenance menus

• Direct access makes software more user-friendly.



New Software Features from AU480/AU680 Analyzer Status

• Color-coding indicates the status of the component

• Select a component, and the software direct links to the appropriate menu

• Position of racks on-board the system can be identified



New Software Features from AU480/AU680 Specific Test Parameters

• When changing between tabs, the Test Name field does not go back to Test No. 1

• A new Test No. button can be used in addition the test Name drop-down list to go to a new test

• A Select button by “Unit” opens a window with pre-programmed units



New Software Features from AU480/AU680 Saving Parameters and Data

• A range (set the starting and ending index) of data indexes can be saved for sample, repeat, calibration, and QC data

New from AU2700/AU5400:• Parameters and data (sample,

repeat, calibration, QC) can be saved to a CD or USB

• Ability to download Reaction Monitor data to a CD or USB

• Data can be uploaded to excel, and emailed to Technical Support to aid in troubleshooting



New Software Features from AU480/AU680 Data Print Options in List Format

• Print options for realtime and batch list formats for reagent blank, calibration, QC, and samples can be set in List Format. Previously required by BCI personnel in System Maintenance

• Print Direction: Portrait: The font is small, but

more samples print per page Horizontal: The font is larger,

but less samples print per page

• Paper Size: Set to A3, A4, Letter, Legal, or

TabloidNote: Printer Sheet Size and Sheet options in System Maintenance only affect the printout when Print (F8) is selected in a specific menu.



New Software Features from AU480/AU680 List Format Options

In System > Format > List Format:

1. Format Test Dilution to print “Normal”, “Dilute”, or “Condense”. If formatted, “Normal” appears on all the original run tests. “Normal”, “Dilute” or “Condense” appears on the repeat run depending on the repeat criteria.

2. Format Pre-Dilution Rate to print “x 1”. If formatted, the Pre-Dilution rate entered in Specific Test Parameters prints for the original run, and the Pre-dilution rate entered in Repeat Specific prints for the repeat run.

3. Format Sample Dilution Rate to print “S. Dil. Rate x 1”. Sample Dilution Rate is a manual dilution rate made on a sample. The sample dilution rate is entered in Sample > Start Entry (F1) > Sample Dilution (F7).



Software ChangesSpecific Test Parameters

Parameters > Specific Test Parameters

Diluent Bottle:

• Outside: Place the bottle with diluent in positions 55. Diluent/W2 and 56. Diluent/W2 outside of the R1 compartment on the analyzer

• Inside: Assign (fix) a bottle with diluent to a reagent position (1 to 54) inside the R1 compartment.



Software ChangesReagent Management

• Dilution (DIL), Clean (CLN), and Detergent (DET) bottles are identified as “I1”, “O1”, “I2”, and “O2”.

“I” and “O” does indicates the Inner or Outer cuvette wheel.

“1” or “2” indicates the R1 or R2 refrigerated compartment.



Software ChangesCommon Test Parameters

Parameters > Common Test Parameters > Test Name

• TBIL and DBIL are automatically assigned to Outer afterprogramming the tests in Sample Blank (F5). TBIL and DBIL can be programmed to Inner from the Test Name tab, but automatically switch to Outer and become grayed out after programming in Sample Blank (F5)

• TBIL and DBIL are automatically assigned to Inner on the AU2700 and AU5400.



Software ChangesMulti-Rack ID

Parameters>Calibration Parameters>Calibrators

• Multi-Rack “No”:

On the AU5820, AU5830, and AU5840,Display Cup Set (F5) in the calibration requisition menu displays 1001, 2001, 3001, and 4001 for the reagent blank rack ID. Blue racks are processed simultaneously on all units

On a AU5810, multi-rack ID is not an option, and Display Cup Set (F5) in the calibration requisition menu displays 0001 for the reagent blank rack ID

• Multi-Rack “Yes”:

Not used often because it is necessary to pour multiple racks of calibrator and/or QC material.



Software ChangeReagent Inventory

• Reagent volume required for each test by the day of the week can be calculated from data obtained from the analyzer (Auto), or a value can be entered for each test and day of the week (Manual)

• Reagent Inventory displays the number of test shots used each day of the week for each sample type within the period set by the index range

• Use Reagent Inventory to determine how much reagent should be on-board for each day of the week



Software ChangesReagent Inventory

• Tests highlighted in green are below the Expected Volumes calculated in Reagent Inventory

• Select Inventory Check (F6) to view the Expected Volume, Onboard Volume, and Difference for each day of the week with Auto or Manual calculations

• AU480 and AU680 do not have the Inventory Check (F6) option.

• On the AU400, AU640, AU2700, and AU5400 this information could be viewed from Start Condition > Inventory Check (F8)



Reagent ConsumptionNew Software Features from AU2700/AU5400

• Shot Total is the cumulative number of tests run on the analyzer form the installation of the instrument. (Default display)

• Select Test Shots after setting the index range and sample type. The number of reagent dispenses for each test and sample type displays. The number of Samples displays for Routine, Emergency, Repeat, and ISE

• Select Test Total after setting the index range and sample type. The number of reagent dispenses for each test and sample type displays. The number of Samples displays for Routine, Emergency, and Repeat. The number of ISE tests (Na, K, and Cl) displays.

• Reagent consumption data can be saved to a CD or USB by selecting Perform (F7)

Note: On the AU480/AU680 the option to save to a CD or USB is Report (F7)



QC Graphs: Daily Charts MenuNew Software Features from AU2700/AU5400

• Ability to plot multiple QC points per index. AU2700/AU5400 averaged

multiple QC points per index.• 300 indexes of QC data are

automatically saved.• Highlight a date and time listed

vertically under the chart to view specific data associated with that point

• Ability to access Reaction Monitor menu directly



Default Sample TypeNew Software Features from AU2700/AU5400

• Ability to select the default sample type in the System Condition menu:

All menus display the Default Type selected in System Condition from the “Type” drop-down

Benefit for Toxicology labs and Drugs of Abuse testing labs that only run urine samples



Calibration ParametersNew Software Features from AU2700/AU5400

• Ability to program all calibrator concentrations for one calibrator material on one new screen.

AU2700/AU5400 required paging through each test in the Calibration Specific menu

Easier and less room for operator error on AU5800

AU2700/AU5400

AU5800



Reagent ManagementNew Software Features from AU2700/AU5400

• Ability to monitor RB Stability, Calibration Stability, and Onboard Stability in hours After 3 days, the display

changes to hours. Example: 3D to 71H

• Ability to generate a “Calibration Expires Soon” warning for a user-defined number of hours (done in System Maintenance by BCI personnel

The programmed number of hours also generates an automatic reagent blank or calibration requisition



Assay Specific LIHNew Software Features from AU2700/AU5400

• Sample Specific LIH: AU2700/AU5400 and

AU5800: Flags sample for the level of lipemia, icterus, and hemolysis detected

• Assay Specific LIH: AU5800 and

AU480/AU680: A specific flag is attached to the tests run on the sample that are known to be affected at a specific threshold of interference.

Barcoded LIH reagent must be used

Printout Example:S.No.0001 0003-01 S.ID 123456

CRE 0.6 CHOL 280 TBIL 0.3 DBIL 0.3 h

LIP + ICT N HEM ++



Specific Test ParametersNew Software Features from AU2700/AU5400

Parameters > Specific Test Parameters

• Correlation Factor:

Corrects the concentration value with the equation Y = AX + B. The Correlation correction is performed after checking the dynamic range.

• Factor for Maker:

Corrects the concentration value with the equation Y = AX + B. The Factor for Maker correction is performed before checking the dynamic range.

• If a Correlation Factor and a Factor for Maker are programmed, the results are calculated with both factors.Note: Changes to Factor for Maker require a password used by the FAS



Default QC ProfileNew Software Features from AU2700/AU5400

• Program the default QC profile for each Sample Type and Group in use in Common Test Parameters > Profile > QC.

• The default QC profile is automatically requisitioned in the QC Requisition menu.

Profile 87: Serum Group 1Profile 88: Serum Group 2Profile 89: Serum Group 3Profile 90: Urine Group 1Profile 91: Urine Group 2Profile 92: Urine Group 3Profile 93: Other-1 Group 1Profile 94: Other-1 Group 2Profile 95: Other-1 Group 3Profile 96: Other-2 Group 1Profile 97: Other-2 Group 2Profile 98: Other-2 Group 3



QC for Calculated TestsNew Software Features from AU2700/AU5400

• Define up to 10 calculated tests in Specific Test Parameters > Calculated Tests.

• At QC Perform, select Yes to be able to program QC ranges in QC Specific for the calculated test.

• To perform QC on HbA1c, QC Specific ranges must be programmed for the % HbA1c, HbA1c, and THb tests.



Contamination Parameters New Software Features from AU2700/AU5400

• Cleaning solution bottles for contamination prevention are located outside of the R1 and R2 refrigerators for additional onboard reagent positions compared to the AU2700/AU5400. R1: positions 57. CLN-1, 58. CLN-2,

59. CLN-1, and 60. CLN-2




AU5800 hardware, features and comparisons to other AU models

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