Asymmetric Total Synthesis of...
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• Bufospirostenin A (1), an unusual steroid • It is used as anti cancer agent and possess cardioactive effect • Structurally, it contains ü Unusual [5-7-6-5-5-6] ring system ü First spirostanol found in animals ü 11 Sterocenters: 10 contiguous, 2 quaternary, 1 spiroketal ü No total synthesis reported Lakshmi R Liu Research Group Total synthesis presentation 12/09/2020 1 Asymmetric Total Synthesis of Bufospirostenin A M.-J. Cheng, L.-P. Zhong, C.-C. Gu, X.-J. Zhu, B. Chen, J.-S. Liu, L. Wang,* W.-C. Ye,* and C.-C. Li* Cheng et al., J. Am. Chem. Soc. 2020, 142, 12602 Bufospirostenin A (1)
Transcript of Asymmetric Total Synthesis of...
• Bufospirostenin A (1), an unusual steroid
• It is used as anti cancer agent and possess cardioactive effect
• Structurally, it contains ü Unusual [5-7-6-5-5-6] ring systemü First spirostanol found in animalsü 11 Sterocenters: 10 contiguous, 2 quaternary, 1
spiroketalü No total synthesis reported
Lakshmi RLiu Research Group
Total synthesis presentation12/09/2020 1
Asymmetric Total Synthesis of Bufospirostenin AM.-J. Cheng, L.-P. Zhong, C.-C. Gu, X.-J. Zhu, B. Chen, J.-S. Liu, L. Wang,* W.-C. Ye,* and C.-C. Li*
Cheng et al., J. Am. Chem. Soc. 2020, 142, 12602
Bufospirostenin A (1)
Retrosynthetic analysis of Bufospirostenin A (1)
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