Asthma
-
Upload
allegra-moses -
Category
Documents
-
view
21 -
download
0
description
Transcript of Asthma
![Page 1: Asthma](https://reader037.fdocuments.net/reader037/viewer/2022110403/56812b4a550346895d8f6ba9/html5/thumbnails/1.jpg)
Asthma
A Chronic disease of the airways that may cause:
• Wheezing• Breathlessness• Chest tightness• Nighttime or early morning coughing
![Page 2: Asthma](https://reader037.fdocuments.net/reader037/viewer/2022110403/56812b4a550346895d8f6ba9/html5/thumbnails/2.jpg)
![Page 3: Asthma](https://reader037.fdocuments.net/reader037/viewer/2022110403/56812b4a550346895d8f6ba9/html5/thumbnails/3.jpg)
The bronchospasm characteristic of the acute asthmatic attack is typically reversible.
(برونکواسپاسم که با درمان بهبود یابد کاراکتریک حمله آسم حاد است)
It improves spontaneously or within minutes to hours of treatment
![Page 4: Asthma](https://reader037.fdocuments.net/reader037/viewer/2022110403/56812b4a550346895d8f6ba9/html5/thumbnails/4.jpg)
Asthma can exist by itself or coexist with:
• chronic bronchitis, or • emphysema, or • bronchiectasis
![Page 5: Asthma](https://reader037.fdocuments.net/reader037/viewer/2022110403/56812b4a550346895d8f6ba9/html5/thumbnails/5.jpg)
Symptoms/Chief Complaint
• Progressive dyspnea• Cough• Chest tightness• Wheezing/coughing
![Page 6: Asthma](https://reader037.fdocuments.net/reader037/viewer/2022110403/56812b4a550346895d8f6ba9/html5/thumbnails/6.jpg)
• The rapidly reversible airflow obstruction of asthma is mainly due to bronchial smooth muscle contraction
![Page 7: Asthma](https://reader037.fdocuments.net/reader037/viewer/2022110403/56812b4a550346895d8f6ba9/html5/thumbnails/7.jpg)
Focus of Therapy
• Pharmacologic manipulation of airway smooth muscle
• Do not overlook physiologic impairment caused by mucous production and mucosal edema
• Bronchospasm can be reversed in minutes• Airflow obstruction due to mucous plugging
and inflammatory changes in bronchial walls may not resolve for days/weeks - • may lead to atelectasis, infectious
bronchitis, pneumonitis
![Page 8: Asthma](https://reader037.fdocuments.net/reader037/viewer/2022110403/56812b4a550346895d8f6ba9/html5/thumbnails/8.jpg)
Asthma Triggers• Immunologic reaction• Viral respiratory/sinus infections• change in temperature/humidity• Drugs/Chemicals -
• aspirin, NSAIDS• Exercise• GE Reflux• Laughing/coughing• Environmental factors -
• strong odors, pollutants, dust, fumes
![Page 9: Asthma](https://reader037.fdocuments.net/reader037/viewer/2022110403/56812b4a550346895d8f6ba9/html5/thumbnails/9.jpg)
Patient Exam• Wheezing
• may be audible w/o stethoscope• ویز در آسم معموال بازدمی است (بازدم طوالنی تر است)• شدت ویز با شدت آسم ارتباطی ندارد
• Use of accessory muscles of inspiration• (... رتراکسیون بین دنده ای و)
• diaphragmatic fatigue• Paradoxical respirations
• (شکم و قفسه سینه عکس هم حرکت میکنند)• خستگی عضالت تنفسی و احتمال آپنه تنفسی• Reflect impending ventilatory failure
• Altered mental status -• lethargy, exhaustion, agitation, confusion
![Page 10: Asthma](https://reader037.fdocuments.net/reader037/viewer/2022110403/56812b4a550346895d8f6ba9/html5/thumbnails/10.jpg)
Patient Exam• Hyperrsonance to percussion
• decreased intensity of breath sounds
• prolongation of expiratory phase w or w/o wheezing
• The intensity of the wheeze may not correlate with the severity of airflow obstruction
• “quiet chest” - very severe airflow obstruction
![Page 11: Asthma](https://reader037.fdocuments.net/reader037/viewer/2022110403/56812b4a550346895d8f6ba9/html5/thumbnails/11.jpg)
Risk factors for death from asthma:
• Past history of sudden severe exacerbations
• Prior intubation for asthma
• Prior admission for asthma to an intensive care unit
• Two or more hospitalizations for asthma in the past year
• Three or more emergency care visits for asthma in the past year
• Hospitalization or emergency care visit for asthma within the past month
• Use of more than two canisters per month of inhaled short-acting 2-agonist
• Current use of systemic corticosteroids or recent withdrawal from systemic corticosteroids
• Difficulty perceiving airflow obstruction or its severity
• Comorbidity, as from cardiovascular diseases or chronic obstructive pulmonary disease
• Serious psychiatric illness or psychosocial problems
• Low socioeconomic status in urban residents
• Illicit drug use
![Page 12: Asthma](https://reader037.fdocuments.net/reader037/viewer/2022110403/56812b4a550346895d8f6ba9/html5/thumbnails/12.jpg)
Asthma Treatment
• Nebulized B-adrenergic drugs• Corticosteroids• Nebulized anticholinergics• Magnesium sulfate• Oxygen• Long acting beta-agonists• Inhaled steroids
![Page 13: Asthma](https://reader037.fdocuments.net/reader037/viewer/2022110403/56812b4a550346895d8f6ba9/html5/thumbnails/13.jpg)
Managing Asthma:
Indications of a severe attack:
• Breathless at rest(تنگی نفس در استراحت) • hunched forward(روی تخت خم شود) • talking in words rather than sentences (استفاده از کلمات بریده)
• Agitated• (Peak flow rate) PFR< 60% of normal in Spirometry
![Page 14: Asthma](https://reader037.fdocuments.net/reader037/viewer/2022110403/56812b4a550346895d8f6ba9/html5/thumbnails/14.jpg)
Treatment Goals of Severe Asthma
• Improve airway function rapidly• Avoid hypoxemia• Prevent respiratory failure and
death
![Page 15: Asthma](https://reader037.fdocuments.net/reader037/viewer/2022110403/56812b4a550346895d8f6ba9/html5/thumbnails/15.jpg)
Classifying Severity of Asthma Exacerbations
Symptoms Mild Moderate Severe
Breathlessness walking talking at rest
Position Can lie down Prefers sitting upright
Talks in Sentences Phrases Words
Alertness May be agitated Usually agitated Usually agitated
![Page 16: Asthma](https://reader037.fdocuments.net/reader037/viewer/2022110403/56812b4a550346895d8f6ba9/html5/thumbnails/16.jpg)
Classifying Severity of Asthma Exacerbations
Signs Mild Moderate Severe
Pulsus Paradoxusنکته: اختالف فشارخون بین دم و بازدم بیمار =
![Page 17: Asthma](https://reader037.fdocuments.net/reader037/viewer/2022110403/56812b4a550346895d8f6ba9/html5/thumbnails/17.jpg)
Classifying Severity of Asthma Exacerbations
Functional assessment Mild Moderate Severe
نکته: در اورژانس پالس اکسیمتری موجود است که میتوانیم بر اساس آن آسم را طبقه بندی کنیم
![Page 18: Asthma](https://reader037.fdocuments.net/reader037/viewer/2022110403/56812b4a550346895d8f6ba9/html5/thumbnails/18.jpg)
Respiratory Arrest Imminent
• Drowsy or confused
• Paradoxical thoracoabdominal movement
• Absent Wheeze
• Bradycardia
• Absence Pulsus paradoxus suggests respiratory muscle fatigue
![Page 19: Asthma](https://reader037.fdocuments.net/reader037/viewer/2022110403/56812b4a550346895d8f6ba9/html5/thumbnails/19.jpg)
Asthma Mimickers((تشخیص افتراقی های آسم
• Congestive heart failure ("cardiac asthma")• Upper airway obstruction• Aspiration of foreign body or gastric acid• Bronchogenic carcinoma with endobronchial
obstruction• Metastatic carcinoma with lymphangitic
metastasis• Sarcoidosis with endobronchial obstruction• Vocal cord dysfunction• Multiple pulmonary emboli (rare)
![Page 20: Asthma](https://reader037.fdocuments.net/reader037/viewer/2022110403/56812b4a550346895d8f6ba9/html5/thumbnails/20.jpg)
treatment of acute asthma
Goal in the ED• reverse airflow obstruction
rapidly by repetitive or continuous administration of inhaled 2-agonists
• ensure adequate oxygenation
• relieve inflammation
![Page 21: Asthma](https://reader037.fdocuments.net/reader037/viewer/2022110403/56812b4a550346895d8f6ba9/html5/thumbnails/21.jpg)
Initial Assessment
• History• physical examination
(auscultation use of accessory muscles, heart rate, respiratory rate)
• PEFR or FEV• oxygen saturation• other tests as indicated
![Page 22: Asthma](https://reader037.fdocuments.net/reader037/viewer/2022110403/56812b4a550346895d8f6ba9/html5/thumbnails/22.jpg)
Diagnosis
• Bedside spirometry • rapid, objective assessment ,guide to the effectiveness of
therapy.• The forced expiratory volume in 1 s (FEV1)• peak expiratory flow rate (PEFR)
• Sequential measurements
• management decisions
![Page 23: Asthma](https://reader037.fdocuments.net/reader037/viewer/2022110403/56812b4a550346895d8f6ba9/html5/thumbnails/23.jpg)
Pulse oximetry
• assessing oxygenation and monitoring oxygen saturation during treatment.
• ABG is not indicated in most patients with mild to moderate asthma exacerbation
را بدانیم)PCO2 نیاز نیست مگر اینکه بخواهیم سطح ABG(در همه بیماران آسمی
![Page 24: Asthma](https://reader037.fdocuments.net/reader037/viewer/2022110403/56812b4a550346895d8f6ba9/html5/thumbnails/24.jpg)
ABG
assess for hypoventilation with carbon dioxide retention and respiratory acidosis
• clinical evidence of severe attacks
• PEFR or FEV1 of less than 25 percent predicted
• With acute attacks, ventilation is stimulated, resulting in a decrease in partial pressure of carbon dioxide (PaCO2)• normal or slightly elevated PaCO2 (e.g., 42 mm Hg)
indicates extreme airway obstruction and fatigue and may herald the onset of acute ventilatory failure
![Page 25: Asthma](https://reader037.fdocuments.net/reader037/viewer/2022110403/56812b4a550346895d8f6ba9/html5/thumbnails/25.jpg)
Radiography
• clinical indication of a complication • pneumothorax, pneumomediastinum,
pneumonia, or other medical concern• one-third of asthma exacerbations
requiring admission, will demonstrate an abnormality on chest radiograph
CXR )) ها افتراقی تشخیص و تریگر پیداکردن برای مگر نیست کننده کمک
![Page 26: Asthma](https://reader037.fdocuments.net/reader037/viewer/2022110403/56812b4a550346895d8f6ba9/html5/thumbnails/26.jpg)
CBC
اندیکاسیون ندارد
• modest leukocytosis secondary to administration of:
B -agonist therapy or corticosteroid treatment
• In patients taking theophylline before ED presentation, a serum theophylline level
شود چک تئوفیلین سطح میگرفته تئوفیلین که بیماری
![Page 27: Asthma](https://reader037.fdocuments.net/reader037/viewer/2022110403/56812b4a550346895d8f6ba9/html5/thumbnails/27.jpg)
ECG
• Routine electrocardiogram is unnecessary which resolve with treatment:
1. right ventricular strain, or2. abnormal P waves, or3. nonspecific ST- and T-wave abnormalities
Older patients, especially those with coexisting heart disease, should have cardiac monitoring during treatment
(EKG میگیریم دارند قلبی ای زمینه بیماری که بیمارانی در) میگردند رفع آسم بادرمان که میشوند دیده اختصاصی غیر تغییرات روتین طور به زیرا
![Page 28: Asthma](https://reader037.fdocuments.net/reader037/viewer/2022110403/56812b4a550346895d8f6ba9/html5/thumbnails/28.jpg)
Impending or Actual Respiratory Arrest
• Intubation and mechanical ventilation with 100% 02
• Nebulized B2 agonist and anticholinergic
• Intravenous steroid
• Admit to ICU
![Page 29: Asthma](https://reader037.fdocuments.net/reader037/viewer/2022110403/56812b4a550346895d8f6ba9/html5/thumbnails/29.jpg)
اساس بر یا FEV1 درمانPEFR
FEV1 or PEFR >50%So2%≥90اکسیژن تا رساندن • بار در ساعت اول3 تا ß2-agonistاستنشاق • استرویید خوراکی (اگر درمانهای باال فورا جواب نداد یا اخیرا داروی استرویید خوراکی •
مصرف میکرده است)
دقیقه20 پاف هر 8, از اسپری سالبوتامول آگونیست (سالبوتامول) نداریم 2نکته: چون نبوالیزر بتا بار و سپس ارزیابی مجدد3میدهیم تا
FEV1 or PEFR <50%)Severe Exacerbation(
So2%≥90اکسیژن تا رساندن •دقیقه یا مداوم برای 20 و آنتی کولینرژیک با نبوالیزر هر ß2-agonistاستنشاق دوز زیاد •
مدت یک ساعت. استرویید خوراکی•
![Page 30: Asthma](https://reader037.fdocuments.net/reader037/viewer/2022110403/56812b4a550346895d8f6ba9/html5/thumbnails/30.jpg)
Repeat Assessment
• Symptoms. • physical examination. • PEFR. • 02 saturation. • other test as needed
![Page 31: Asthma](https://reader037.fdocuments.net/reader037/viewer/2022110403/56812b4a550346895d8f6ba9/html5/thumbnails/31.jpg)
Severe Exacerbation
![Page 32: Asthma](https://reader037.fdocuments.net/reader037/viewer/2022110403/56812b4a550346895d8f6ba9/html5/thumbnails/32.jpg)
Moderate Exacerbation
![Page 33: Asthma](https://reader037.fdocuments.net/reader037/viewer/2022110403/56812b4a550346895d8f6ba9/html5/thumbnails/33.jpg)
Incomplete Response
![Page 34: Asthma](https://reader037.fdocuments.net/reader037/viewer/2022110403/56812b4a550346895d8f6ba9/html5/thumbnails/34.jpg)
Good Response
![Page 35: Asthma](https://reader037.fdocuments.net/reader037/viewer/2022110403/56812b4a550346895d8f6ba9/html5/thumbnails/35.jpg)
Discharge Home
![Page 36: Asthma](https://reader037.fdocuments.net/reader037/viewer/2022110403/56812b4a550346895d8f6ba9/html5/thumbnails/36.jpg)
Poor Response
![Page 37: Asthma](https://reader037.fdocuments.net/reader037/viewer/2022110403/56812b4a550346895d8f6ba9/html5/thumbnails/37.jpg)
Poor Response
![Page 38: Asthma](https://reader037.fdocuments.net/reader037/viewer/2022110403/56812b4a550346895d8f6ba9/html5/thumbnails/38.jpg)
Poor Response
![Page 39: Asthma](https://reader037.fdocuments.net/reader037/viewer/2022110403/56812b4a550346895d8f6ba9/html5/thumbnails/39.jpg)
medications are used in the treatment of acute asthma
• adrenergic agonists• anticholinergics • glucocorticoids• Magnesium, heliox (mixture of helium
and oxygen), and ketamine may be considered when the aforementioned medications fail to relieve bronchospasm.
• Mast cell-stabilizing agents, methylxanthines, and leukotriene modifiers are currently reserved for maintenance therapy only
![Page 40: Asthma](https://reader037.fdocuments.net/reader037/viewer/2022110403/56812b4a550346895d8f6ba9/html5/thumbnails/40.jpg)
Adrenergic Agents
• Adrenergic receptors
• Stimulation of B 1-receptors increases rate and force of cardiac contraction and decreases small intestine motility and tone
• B2-adrenergic stimulation promotes bronchodilation, vasodilation, uterine relaxation, and skeletal muscle tremor
![Page 41: Asthma](https://reader037.fdocuments.net/reader037/viewer/2022110403/56812b4a550346895d8f6ba9/html5/thumbnails/41.jpg)
Adrenergic Agents
• stimulation of the enzyme adenyl cyclase, which converts intracellular adenosine triphosphate into cyclic adenosine monophosphate
• enhances the binding of intracellular calcium to cell membranes, reducing the myoplasmic calcium concentration, and results in relaxation of bronchial smooth muscle
• inhibit mediator release and promote mucociliary clearance.
![Page 42: Asthma](https://reader037.fdocuments.net/reader037/viewer/2022110403/56812b4a550346895d8f6ba9/html5/thumbnails/42.jpg)
side effect of B-adrenergic drugs:
• skeletal muscle tremor (most common)• nervousness, anxiety, • insomnia, headache, • hyperglycemia,• palpitations, tachycardia, and hypertension• potential cardiotoxicity(combination with
theophylline not significant problems)• Arrhythmias and evidence of myocardial
ischemia(rare)
![Page 43: Asthma](https://reader037.fdocuments.net/reader037/viewer/2022110403/56812b4a550346895d8f6ba9/html5/thumbnails/43.jpg)
Inhaled short-acting B-2 agonists
Albuterol • Nebulizer solution (5 mg/mL)
• 2.5–5.0 mg every 20 min for 3 doses• then 2.5–10 mg every 1–4 h as needed or
10–15 mg per h continuously• Only selective B-2 agonists are
recommended• for optimal delivery, dilute aerosols to
minimum of 4 mL at gas flow of 6–8 L per min
![Page 44: Asthma](https://reader037.fdocuments.net/reader037/viewer/2022110403/56812b4a550346895d8f6ba9/html5/thumbnails/44.jpg)
Albuterol
• (MDI) Meter Dose Inhalation (90μ/puff)
• 4–8 puffs every 20 min up to 4 h
• then every 1–4 h as needed
• As effective as nebulized therapy if patient is able to coordinate inhalation maneuver; use spacer/holding chamber
![Page 45: Asthma](https://reader037.fdocuments.net/reader037/viewer/2022110403/56812b4a550346895d8f6ba9/html5/thumbnails/45.jpg)
Inhaled short-acting B-2 agonists
• Bitolterol • Nebulizer solution (2 mg/mL) • MDI (370 macg/puff)
• Pirbuterol • MDI (200 g/puff)
![Page 46: Asthma](https://reader037.fdocuments.net/reader037/viewer/2022110403/56812b4a550346895d8f6ba9/html5/thumbnails/46.jpg)
Inhaled short-acting B-2 agonists
• Systemic (injected), B-2 agonists
• Epinephrine (1:1000 or 1 mg/mL)• 0.3–0.5 mg SC every 20 min for 3 doses
• Terbutaline (1 mg/mL)• 0.25 mg SC every 20 min for 3 doses
No proven advantage of systemic therapy over aerosol
![Page 47: Asthma](https://reader037.fdocuments.net/reader037/viewer/2022110403/56812b4a550346895d8f6ba9/html5/thumbnails/47.jpg)
Anticholinergics • potent bronchodilators in patients with asthma
and other forms of obstructive lung disease • anticholinergics affect large, central airways,
• whereas B-adrenergic drugs dilate smaller airways • competitively antagonize acetylcholine at the
postganglionic junction between the parasympathetic nerve terminal and effector cell
• blocks the bronchoconstriction induced by vagal cholinergic-mediated innervation to the larger central airways
• concentrations of cyclic guanosine monophosphate in airway smooth muscle are reduced,further promotin bronchodilation
![Page 48: Asthma](https://reader037.fdocuments.net/reader037/viewer/2022110403/56812b4a550346895d8f6ba9/html5/thumbnails/48.jpg)
Anticholinergics
Ipratropium bromide • Nebulizer solution (0.2 mg/mL)
• 0.5 mg every 30 min for 3 doses• then every 2–4 h as needed
• Should not be used as first-line therapy;• should be added to 2 agonist therapy; • may mix in same nebulizer with albuterol
• MDI (18 g/puff)• 4–8 puffs every 6–8 h
![Page 49: Asthma](https://reader037.fdocuments.net/reader037/viewer/2022110403/56812b4a550346895d8f6ba9/html5/thumbnails/49.jpg)
side effects
• dry mouth• Thirst• difficulty swallowing• Less commonly
• tachycardia, restlessness, irritability, confusion, difficulty in micturition, ileus, blurring of vision, or an increase in intraocular pressure
![Page 50: Asthma](https://reader037.fdocuments.net/reader037/viewer/2022110403/56812b4a550346895d8f6ba9/html5/thumbnails/50.jpg)
Corticosteroids
• highly effective drugs in asthma exacerbation
• one of the cornerstones of treatment• mechanism of action is unknown( مکانیسم فعالیت نامشخص
(است
• Restoring B-adrenergic responsiveness • reducing inflammation• The onset of anti-inflammatory effect is delayed at
least 4 to 8 h after intravenous or oral administration.
ساعت بعد از مصرف خوراکی یا وریدی, اثرات آن شروع میشود)8) تا 4
![Page 51: Asthma](https://reader037.fdocuments.net/reader037/viewer/2022110403/56812b4a550346895d8f6ba9/html5/thumbnails/51.jpg)
Corticosteroids
• administered within 1 h of arrival in the ED• reduces the need for hospitalization• prednisone 40 to 60 mg, oral• methylprednisolone 60 to 125 mg IV
• High-dose corticosteroid therapy offers no advantage
• Additional doses should be given every 4 to 6 h until significant subjective and objective improvements are achieved
• discharging all patients with mild persistent or more severe asthma on maintenance inhaled corticosteroids in addition to a burst of oral corticosteroid
![Page 52: Asthma](https://reader037.fdocuments.net/reader037/viewer/2022110403/56812b4a550346895d8f6ba9/html5/thumbnails/52.jpg)
Corticosteroids
• Prednisone• Methylprednisolone • Prednisolone
• 120–180 mg per d in 3 or 4 divided doses for 48 h,
• then 60–80 mg per d until FEV1, or PEFR reaches 70% of predicted or personal best
• For outpatient "burst," use 40–60 mg per d, for 3–10 d in adults
![Page 53: Asthma](https://reader037.fdocuments.net/reader037/viewer/2022110403/56812b4a550346895d8f6ba9/html5/thumbnails/53.jpg)
Theophylline• no longer considered a first-line treatment • in combination with inhaled B 2-adrenergic
drugs,• increase the toxicity, but not the efficacy, of
treatment• more sustained bronchodilator effect,
improving respiratory muscle endurance• improving resistance to fatigue• anti-inflammatory
side effects • nervousness, nausea, vomiting, anorexia, and
headache• At plasma levels greater than 30 g/mL, there
is a risk of seizures and cardiac arrhythmias.
![Page 54: Asthma](https://reader037.fdocuments.net/reader037/viewer/2022110403/56812b4a550346895d8f6ba9/html5/thumbnails/54.jpg)
magnesium sulfate
• acute, very severe asthma (i.e., FEV1 <25 percent predicted)
• The dose is 1 to 2 g IV over 30 min.
![Page 55: Asthma](https://reader037.fdocuments.net/reader037/viewer/2022110403/56812b4a550346895d8f6ba9/html5/thumbnails/55.jpg)
• Heliox, Ketamine, and Halothane • Mast Cell Modifiers • Leukotriene Modifiers
![Page 56: Asthma](https://reader037.fdocuments.net/reader037/viewer/2022110403/56812b4a550346895d8f6ba9/html5/thumbnails/56.jpg)
Mechanical Ventilation
• progressive hypercarbia and acidosis
• Exhausted• confused,
• does not relieve the airflow obstruction eliminates the work of breathing and enables the patient to rest while the airflow obstruction is resolved
• Direct oral intubation