Assessing Asthma Control and Quality Care in …...Patient-Reported Outcomes • Random sample of...
Transcript of Assessing Asthma Control and Quality Care in …...Patient-Reported Outcomes • Random sample of...
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Asthma Population Management: Identifying Persistent Asthma,
Defining High Risk Asthma, and Measuring Quality of Asthma Care
Michael Schatz, MD, MS
Allergy Department Kaiser Permanente, San Diego,
CA
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Constructs to be Measured
• Severity (Persistent Asthma) • Control
– Impairment – Exacerbations
• Quality of Care
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Types of Administrative Data Used
• Encounter diagnosis of asthma – Hospital – Emergency Department – Outpatient
• Pharmacy data – Short-acting beta agonist canisters – Oral corticosteroid dispensings – Controller units and percent of days covered
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Outline of Presentation • Assessment of Severity
– Persistent asthma (HEDIS) • Assessment of Impairment
– Short-acting β-agonist canister dispensings • Assessment of Risk (Exacerbations)
– Prior exacerbations – Short-acting β-agonist canister dispensings
• Assessment of Quality Care (HEDIS) – Any controller measure – Medication ratio measure – Adherence measure
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Outline of Presentation • Assessment of Severity
– Persistent asthma (HEDIS) • Assessment of Impairment
– Short-acting β-agonist canister dispensings • Assessment of Risk (Exacerbations)
– Prior exacerbations – Short-acting β-agonist canister dispensings
• Assessment of Quality Care (HEDIS) – Any controller measure – Medication ratio measure – Adherence measure
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Question
• Which of the following is true regarding the HEDIS definition for persistent asthma? – A. It appears to have low specificity for
persistent asthma based on patient-reported information
– B. It includes pulmonary function measures, which increases its specificity
– C. A two year definition increases its specificity
– D. It does not include exacerbations
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HEDIS Persistent Asthma
• HEDIS definition of persistent asthma – > 4 or more asthma medication dispensing
events – > 1 ED visit with asthma as the principal
diagnosis – > 1 hospital admission with asthma as the
principal diagnosis – 4 ambulatory visits with asthma and > 2
asthma medication dispensing events • One or two year
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Relationship of HEDIS Persistent Asthma to Survey Persistent Asthma
• 2,895 HEDIS patients in 2006 completed survey in fall 2007
• Survey-defined persistent asthma – Daytime and nighttime symptoms – Rescue therapy – Activity limitation – Regular controller therapy – Exacerbations (> 1 requiring oral CS in past
12 months) Schatz, et al. Am J Manag Care 2010; 16: e281
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Relationship of HEDIS to Survey Persistent Asthma (PA)
• 86.9 % of patients reported survey PA • Follow-up survey 5 month later
– 95 % with 1st survey PA had PA on 2nd survey – 54 % of those without 1st survey PA had PA on
2nd survey • HEDIS requalification in 2007
– 68 % of patients with survey PA versus 22 % without survey PA
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2007 HEDIS
requalification
2008 utilization
Yes
(N=1,712)
No
(N=805)
P Value*
Hospitalization or ED visit
6.1 % 2.7 % 0.0003
Any oral corticosteroid
37.6 % 28.0 % < .0001
Two or more oral corticosteroids
17.4 % 10.9 % < .0001
SABA > 6 25.4 % 8.9 % < .0001
HEDIS Requalification and Subsequent Utilization
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Persistent Asthma: Conclusions
• HEDIS persistent asthma is generally consistent with survey-defined persistent asthma
• The two year HEDIS population is even more specific for persistent asthma and associated with increased utilization
• The two year HEDIS population is a “valid” population for outreach and quality of care assessment
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Outline of Presentation • Assessment of Severity
– Persistent asthma (HEDIS) • Assessment of Impairment
– Short-acting β-agonist canister dispensings • Assessment of Risk (Exacerbations)
– Prior exacerbations – Short-acting β-agonist canister dispensings
• Assessment of Quality Care (HEDIS) – Any controller measure – Medication ratio measure – Adherence measure
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Beta Agonist Long Term Control Scale
• Beta agonist canister dispensings per year – 0-2 – 3-6 – 7-12 – > 12
• Two samples – Random sample of adult 2250 KP patients
(aged 18-56) with persistent asthma (1999) who completed survey in 2000
– 62,369 members of Southern California KP asthma database in 2002 and 2003
Schatz, et al. J Allergy Clin Immunol 2006;117:995
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Relationship of Beta Agonist Scale to Patient-Reported Outcomes
0
1
2
3
4
5
6
Mean Value
AQLQ ATAQ AOMSOutcome
0 to 23 to 67 to 12> 12
All p < 0.0001
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Question
• Which of the following have been shown to predict an increased risk for asthma exacerbations in children and adults – A. Dispensing > 6 short-acting beta agonist
canisters in a 12 month period – B. Dispensing ≥ 3 short-acting beta agonist
canisters in a 12 month period – C. Prior oral corticosteroid dispensing for
asthma – D. All of the above
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Outline of Presentation • Assessment of Severity
– Persistent asthma (HEDIS) • Assessment of Impairment
– Short-acting β-agonist canister dispensings • Assessment of Risk (Exacerbations)
– Prior exacerbations – Short-acting β-agonist canister dispensings
• Assessment of Quality Care (HEDIS) – Any controller measure – Medication ratio measure – Adherence measure
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Outline of Presentation • Assessment of Severity
– Persistent asthma (HEDIS) • Assessment of Impairment
– Short-acting β-agonist canister dispensings • Assessment of Risk (Exacerbations)
– Prior exacerbations – Short-acting β-agonist canister dispensings
• Assessment of Quality Care (HEDIS) – Any controller measure – Medication ratio measure – Adherence measure
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Relationship of Beta Agonist Scale to Utilization Outcomes
05
101520253035404550
%
Hosp/ED SteroidsOutcome
0 to 23 to 67 to 12> 12
All p < 0.001
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Risk of More Than 6 Short-Acting Beta-agonist Canisters Per Year
• 93,604 patients aged 6-56 • 70 US Health Plans • Risk in following year • Odds Ratios (95 % Confidence Intervals)
– ED/Urgent Care: 6.47 (5.25-7.98) – Hospitalization: 5.37 (6.04-9.76) – Oral corticosteroid: 2.89 (2.72-3.08)
Silver HS, et al. Am J Manag Care 2011; 17:19
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Short-acting Beta-agonist (SABA) Dispensings and Exacerbations
• Commercial and Medicaid Databases • Children aged 4-17 years
– Commercial: 41,753 – Medicaid: 25,048
• Adults aged ≥ 18 years – Commercial: 59,684 – Medicaid: 8,745
• Assessment of SABA in 12 month period • Exacerbation outcomes
Stanford RH, et al. Ann Allergy Asthma Immunol 2012; 109:403
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Prediction of Asthma Exacerbations Cohort Critical SABA
use Exacerbation Odds Ratios (95 % Confidence Interval)
Hospital/ED Visit Oral Corticosteroid
Medicaid Children ≥ 3 in 12 months 1.80 (1.60-2.02) 1.38 (1.28-1.50)
Commercial Children ≥ 3 in 12 months 2.23 (1.94-2.56) 1.60 (1.49-1.71)
Medicaid Adults ≥ 2 in 3 months 1.84 (1.57-2.15) 1.15 (1.03-1.28)
Commercial Adults ≥ 2 in 6 months 2.21 (1.98-2.47) 1.45 (1.38-1.53)
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Outline of Presentation • Assessment of Severity
– Persistent asthma (HEDIS) • Assessment of Impairment
– Short-acting β-agonist canister dispensings • Assessment of Risk (Exacerbations)
– Prior exacerbations – Short-acting β-agonist canister dispensings
• Assessment of Quality Care (HEDIS) – Any controller measure – Medication ratio measure – Adherence measure
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Question
• Which of the following HEDIS measures have been shown to be related to improved asthma outcomes, including patient-reported outcomes – A. Asthma medication ratio measure – B. Asthma adherence measure – C. Any controller measure – D. None of the above
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Outline of Presentation • Assessment of Severity
– Persistent asthma (HEDIS) • Assessment of Impairment
– Short-acting β-agonist canister dispensings • Assessment of Risk (Exacerbations)
– Prior exacerbations – Short-acting β-agonist canister dispensings
• Assessment of Quality Care (HEDIS) – Any controller measure – Medication ratio measure – Adherence measure
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HEDIS Any Controller Numerator
• The following medications are considered
valid controller medications: – Inhaled corticosteroids – Inhaled cromolyn and nedocromil – Oral leukotriene modifier and theophylline
medications – Excludes long-acting beta agonists
Any Asthma Controller Dispensing
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Any Controller Use Is Associated With Increased Risk in HEDIS
Patients • 49,637 patients with
HEDIS-defined persistent asthma in 1999
• 3 health plans in 3 regions • Controller use in year 2000 • Outcome: Asthma-related
ED visit or hospitalization (ED/Hosp) in 6 months following first medication 0
0.5
1
1.5
2
2.5
% ED/Hosp
Controller NoController
Berger, et al. Ann Allergy Asthma Immunol 2004; 93:538
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Outline of Presentation • Assessment of Severity
– Persistent asthma (HEDIS) • Assessment of Impairment
– Short-acting β-agonist canister dispensings • Assessment of Risk (Exacerbations)
– Prior exacerbations – Short-acting β-agonist canister dispensings
• Assessment of Quality Care (HEDIS) – Any controller measure – Medication ratio measure – Adherence measure
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Asthma Medication Ratio
• Controllers/(Controllers + Short-acting Beta Agonists)
• Number of canisters or canister equivalents (30 day supplies of oral controllers)
• Ranges from 0 (no Controllers) to 1.0 (no Short-acting Beta Agonists)
• ≥ 0.5 appears to be the optimal cut-off (in relationship to improved outcomes)
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Relationship of Medication Ratio to Acute Episodes
• 38,433 Southern California Kaiser Permanente patients with persistent asthma
• Medication ratio determined in 2002 • Acute episodes (one or more asthma
emergency department visits or hospitalizations) determined in 2003
Schatz, et al. Chest 2005; 128:1068
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Relationship of Medication Ratio to Acute Episodes
0123456789
% ED or Hospital
< 0.5 > 0.5Medication Ratio
P < 0.0001
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Relation of Medication Ratio to Patient-Reported Outcomes
• Random sample of 2250 adult patients (aged 18-56) with persistent asthma (1999)
• Northern California, Southern California, and Northwest Kaiser Permanente
• Survey completed in Fall, 2000 • Survey included quality of life (AQLQ), control
(ATAQ) and symptom severity (AOMS) • Medication ratio from year 2000 computerized
pharmacy records Schatz, et al. Chest 2006; 130:43
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Relationship of Ratio > 0.5 to Poor Symptom Control
05
101520253035404550
%
AQLQ < 3.9 ATAQ > 1 AOMS > 3Patient-Reported Outcome Tool
Ratio < 0.5Ratio > 0.5
All p < 0.0001
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Medicaid Population • 90,909 Medicaid patients aged 5-56 with
persistent asthma in California and New York • Reduction of risk of exacerbation in follow-up
year in patients with ratio ≥ 0.5 –Aged 5-56 –Aged 5-19 –Aged 20-40 –Aged 41-56
• Increased risk of exacerbations with HEDIS any controller measure in all age groups
Yong, et al. J Allergy Clin Immunol 2009; 124:961
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Predictors of High Medication Ratio
• Higher controller medication possession ratio (adherence)
• Lower SABA dispensings • Specialty care • Combination ICS-LABA therapy • Leukotriene receptor antagonist controller
Broder, et al. Am J Manag Care 2010; 16:170
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Outline of Presentation • Assessment of Severity
– Persistent asthma (HEDIS) • Assessment of Impairment
– Short-acting β-agonist canister dispensings • Assessment of Risk (Exacerbations)
– Prior exacerbations – Short-acting β-agonist canister dispensings
• Assessment of Quality Care (HEDIS) – Any controller measure – Medication ratio measure – Adherence measure
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New HEDIS Adherence Measure
• HEDIS two year persistent asthma denominator
• Two Rates – The percentage of members who remained
on an asthma controller medication for at least 50% of their treatment period
– The percentage of members who remained on an asthma controller medication for at least 75% of their treatment period
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New HEDIS Adherence Measure: Concerns
• Measuring adherence to inhaled medications from pharmacy data is methodologically challenging – Variable accuracy of days supply field – Varying MD directions and patient use – Varying number of puffs per canister
• Relationship of this measure to actual medication adherence is uncertain
• Relationship of this measure to improved outcomes has not been tested
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HEDIS Administrative Data Asthma Quality Measures: Conclusions
• The any controller measure is not related to improved asthma outcomes
• The medication ratio measure is related to improved asthma outcomes (impairment and risk) within health plans
• The relationship of the new adherence measure to asthma outcomes is unknown
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Conclusion: Potential Patients for Intervention
• Persistent asthma and no controllers • Patients with prior exacerbations • Excess short-acting beta agonist canister
dispensings – > 6 in 12 months – Consider ≥ 3 in 12 months in children – Consider ≥ 2 in 6 months in adults
• Medication ratio < 0.5 in patients with persistent asthma