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Transcript of Assembling a Systematic Review Team: Balancing Expertise and Potential Conflicts of Interest...
Assembling a Systematic Review Team: Balancing Expertise and Potential
Conflicts of Interest
Avoiding bias in systematic reviewsAHRQ annual meeting
Bethesda North Marriott Conference CenterSeptember 20, 2011
IOM recommendations
STANDARD 2.1 Establish a team with appropriate expertise and experience to conduct the systematic review
2.1.1 Include expertise in the pertinent clinical content areas
STANDARD 2.2 Manage bias and conflict of interest (COI) of the team conducting the systematic review
2.2.3 Exclude individuals whose professional or intellectual bias would diminish the credibility of the review in the eyes of the intended users
STANDARD 2.4 Manage bias and COI for individuals providing input into the systematic review
2.4.2 Exclude input from individuals whose COI or bias would diminish the credibility of the review in the eyes of the intended users
STANDARD 2.7 Submit the protocol for peer review 2.7.1 Provide a public comment period for the protocol and publicly report on
disposition of comments
Definitions
Bias– a systematic error or deviation from the truth, in results or
inferences (Higgins JPT, et al. Cochrane handbook 2009).– inclination to present or hold a partial perspective at the expense of
(possibly equally valid) alternatives
Conflict of interest (COI) – a set of conditions in which professional judgment concerning a
primary interest (such as the validity of research) tends to be unduly influenced by a secondary interest (such as financial or professional gain) (Thompson, 1993).
Expertise– Extensive knowledge based on research, experience, or
occupation and in a particular area of study. Expert is someone who is a widely recognized authority by peers and public.
Potential biases in systematic reviews
Holding an established opinion on the answers to the research questions of the review; the inclination to present or hold a partial perspective at the expense of (possibly equally valid) alternatives– Individuals in a particular specialty may have an unbalanced
familiarity for one type of intervention or technology.– Individuals livelihood may depend on finding greater benefit of one
type of intervention or technology over a competitor.– Experts may hold a previously formed opinion and be unlikely to
change. Holding an established opinion on the quality of studies to be
included. – Individuals who conducted a study or trial may not be able to
assess the quality of their own or other “competitor” studies in an unbiased manner.
My take home points
We are concerned with bias, but this is difficult to measure. Non-financial conflicts of interest can result in bias.
– Perceived conflicts of interest may still reduce the credibility of the review in the eyes of the intended users
– Conflicts due to familiarity or livelihood based on an intervention or technology can be managed by balancing the team and input from different specialty areas.
Expertise can be a form of bias– May be difficult to discern unless they have published an editorial or
commentary on the subject. – Not including appropriate expertise may reduce the credibility of the
review in the eyes of the intended users– It is important to hear opinions from all sides, but the core team
should be without bias. Individuals should not be involved in grading their own study, either at
the individual study level or at the body of evidence level.
Introductions and Acknowledgements
Susan Norris, Oregon Health and Science University
Gillian Sanders Schmidler, Duke University
AHRQ staff Elise Berliner Christine Chang Yen-Pin Chiang Supriya Janakiraman Elisabeth Kato
Mary Nix
EPC workgroup Eric Bass Stanley Ip Melissa Mcpheeters Sydney Newberry Susan Norris Margaret Piper Paul Shekelle Meera Viswanathan Evelyn Whitlock Renee Wilson Michael White
Objectives
Provide a framework for thinking about intellectual conflict of interest
Review of the existing literature on the potential effects of intellectual conflict of interest
Work through examples of potential conflicts of interest when conducting a systematic review
Case Examples
Procedure specialist
A review is comparing surgical, medical or alternative treatments. Should a specialist who makes a living doing only surgical interventions be the principal investigator?
1. Yes2. Yes, but with restrictions3. No4. It depends
Procedure specialist
A review is comparing surgical, medical or alternative treatments. Should a specialist who makes a living doing only surgical interventions be part of the core team?
1. Yes2. Yes, but balance with other perspectives3. Yes, but with restrictions4. No 5. It depends
Professional society staff
Should a scientist who works for a specialty professional society be the principal investigator of a review?
1. Yes2. Yes, but with restrictions3. No 4. It depends
Professional society staff
Should a scientist who works for a specialty professional society be a co-author of a review?
1. Yes2. Yes, but balance with other
perspectives3. Yes, but with restrictions4. No 5. It depends
Professional society staff
Should a scientist who works for a specialty professional society be on the technical expert panel?
1. Yes2. Yes, but balance with other
perspectives3. Yes, but with restrictions4. No 5. It depends
Professional society staff
Should a scientist who works for a specialty professional society be a peer reviewer?
1. Yes2. Yes, but balance with other
perspectives3. Yes, but with restrictions4. No 5. It depends
Active research in area
A scientist has federal grants to study one of the intervention of interest. Should this person be the principal investigator of the review?
1. Yes2. Yes, but with restrictions3. No 4. It depends
Active research in area
A scientist has federal grants to study one of the intervention of interest. Should this person be a co-author of the review?
1. Yes2. Yes, but balance with other
perspectives3. Yes, but with restrictions4. No 5. It depends
Active research in area
A scientist has federal grants to study one of the intervention of interest. Should this person be on the technical expert panel?
1. Yes2. Yes, but balance with other
perspectives3. Yes, but with restrictions4. No 5. It depends
Active research in area
A scientist has federal grants to study one of the intervention of interest. Should this person be a peer reviewer?
1. Yes2. Yes, but balance with other
perspectives3. Yes, but with restrictions4. No 5. It depends
Published
A scientist was an author of a study that would potentially be included in the review. Should this person be the principal investigator?
1. Yes2. Yes, but with restrictions3. No 4. It depends
Published
A scientist was an author of a study that would potentially be included in the review. Should this person be on the core team?
1. Yes2. Yes, but balance with other
perspectives3. Yes, but with restrictions4. No
Published
A scientist was an author of a study that would potentially be included in the review. Should this person be on the technical expert panel?
1. Yes2. Yes, but balance with other
perspectives3. Yes, but with restrictions4. No
Published
A scientist was an author of a study that would potentially be included in the review. Should this person be a peer reviewer?
1. Yes2. Yes, but balance with other
perspectives3. Yes, but with restrictions4. No 5. It depends
Involved in study
A scientist coordinated one center of a multi-center trial that would potentially be included in a review. Should this be the principal investigator?
1. Yes2. Yes, but with restrictions3. No 4. It depends
Involved in study
A scientist coordinated one center of a multi-center trial that would potentially be included in a review. Should this be part of the core team?
1. Yes2. Yes, but balance with other
perspectives3. Yes, but with restrictions4. No 5. It depends
Published review or guidelines
A scientist has previously published a review or guideline on the subject of the review. Should this person be the principal investigator?
1. Yes2. Yes, but with restrictions3. No 4. It depends
Published review or guidelines
A scientist has previously published a review or guideline on the subject of the review. Should this person be a co-author?
1. Yes2. Yes, but balance with other
perspectives3. Yes, but with restrictions4. No 5. It depends
Scientific advisor or editor
A scientist serves on an advisory or editorial board without financial compensation on a related topic to the review. Should this person be the principal investigator?
1. Yes2. Yes, but with restrictions3. No 4. It depends
Scientific advisor or editor
A scientist serves on an advisory or editorial board without financial compensation on a related topic to the review. Should this person be a co-author?
1. Yes2. Yes, but balance with other perspectives3. Yes, but with restrictions4. No 5. It depends
Scientific advisor or editor
A scientist serves on an advisory or editorial board without financial compensation on a related topic to the review. Should this person be on the technical expert panel?
1. Yes2. Yes, but balance with other perspectives3. Yes, but with restrictions4. No 5. It depends
Scientific advisor or editor
A scientist serves on an advisory or editorial board without financial compensation on a related topic to the review. Should this person be a peer reviewer?
1. Yes2. Yes, but balance with other perspectives3. Yes, but with restrictions4. No 5. It depends