ASPIRIN

I. Pustaka1. Vishnoi N.K, 1982, Advanced Practical Organic Chemistry. Vikas Publishing House PVT Ltd New Delhi, page 331-3322. Fessenden RJ, Fessenden JS, 1994, Organic Chemistry, 5th edition, Brooks/Cole Publishing Company Pacific Grove, California, 512-5133. Furniss, 1978, Vogels Textbook of Practical Organic Chemistry, 4th ed, longman Group, Limited, London, page 831-8324. McMurray J, Organic Chemistry, 5th edition Brooks/Cole Publishing Company Pacific Grove, USA, 864II. Presodur KerjaConversion to acethylsalicylic acid (aspirin). Place 10 g (0,72 mol) of dry salicylic acid and 15 g (14 ml, o,147 mol) of acetic anhydride in a small conical flask, add 5 drops of concentrated sulphuric acid and rotate the flask in order to secure through mixing. Warm on water bath to about 500-600 C, stirring with a thermometer, for about 15 minutes. Allow the mixture to cool and stir occasionaly. Add 150 ml of water, stir well and filter the pump. Dissolve the solid in about 30 ml of hot ethanol and por the solution into about 75 ml of warm water. If solid separates at this point, warm the mixture until solution is complete and then allow the clear solution to cool slowly. Beautiful needle-like crystals will separate. The yield is 11 g (85%). The air-dried crude product may also be recrystallised from ether-light petroleum (b.p 400-600C). Acetylsalicylic acid decomposesylic acid decomposes when heated and does not posses a true, clearly defined m.p. Decomposition points varying from128 to 1350C have been recorded; a value of 129-1330C is obtained on an electric hot plate. Some decomposition may occur if the compound is recrystallised from a solvent of high bolling point or if the boilling period during recrystallisation is undully prolonged. (Furniss, page 831-832)

Kelompok 15