Ascariasis Abby  Ferrell

Ascariasis  is  caused  by  colonization  of  the  nematode  Ascaris  lumbricoides

Ascaris  develops  in  the  gastrointestinal  tract  and  lungs  after  larvae  in  fecal  ma:er  

are  ingested.  

The  most  severe  symptoms  are  caused  by  the  size  of  the  worm,  which  is  capable  of  

blocking  gastrointestinal  pathways  

The  immune  system  responds  primarily  to  larvae  to  manage  parasite  load

Eosinophil  mediated  immunity  is  slow  to  develop,  which  hinders  the  use  of  

vaccines

Neuromuscular  blockers  paralyze  Ascaris  and  allow  it  to  be  cleared  from  the  bowel

Glucose  uptake  inhibitors  prevent  the  effective  construction  of  microtubules,  

affecting  transport

%  of  con

trol  polym

erization

Warm,  humid  conditions  and  poor  sanitation  raise  infection  rates  in  the  

developing  world

Ascariasis  is  controlled  in  the  US  by  sanitation  and  medication,  but  lack  of  

exposure  may  be  a  factor  in  autoimmune  disease

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•  Bethony,  Jefferey.  "ʺSoil-­‐‑transmi:ed  Helminth  Infections:  Ascariasis,  Trichuriasis,  and  Hookworm."ʺ  The  Lancet  367.9521  (2006):  1521-­‐‑532.The  Lancet.  6  May  2006.  Web.  4  Apr.  2016.

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Web.  05  Apr.  2016. •  Guy,  Karen.  "ʺAscaris  Lumbricoides  (human  Intestinal  Roundworm)."ʺ  Animal  Diversity  Web.  

University  of  Michigan,  2011.  Web.  04  Apr.  2016. •  Long,  Sarah  S.,  Larry  K.  Pickering,  and  Charles  G.  Prober.  Principles  and  practice  of  pediatric  

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image/public/ascaris-­‐‑parasite.jpg?itok=RQsQUD8o •  h:ps://upload.wikimedia.org/wikipedia/commons/thumb/a/a8/

Ascaris_lumbricoides_life_cycle.tif/lossless-­‐‑page1-­‐‑220px-­‐‑Ascaris_lumbricoides_life_cycle.tif.png •  h:ps://encrypted-­‐‑tbn3.gstatic.com/images?q=tbn:ANd9GcStMmAdvhFCK3gZt_  

umrZ7LUfmWJJy3U9ULjn-­‐‑RfN5ZIEjrrRd •  h:ps://encrypted-­‐‑tbn0.gstatic.com/images?q=tbn:ANd9GcQ0PUdOGEWj3_ •  6Iy4D9cIpYmo2TyIlGyF3dPV1AOFJZfO8opfGZ •  h:p://www.utmb.edu/meded/pathoimages/large/infdis/ascaris.jpg •  h:p://www.nature.com/nchem/journal/v1/n8/images/nchem.427-­‐‑f1.jpg •  h:ps://encrypted-­‐‑tbn2.gstatic.com/images?

q=tbn:ANd9GcQ0tPBrgN1tk9ld6CuqHN1nRcZY2FHohbqbJZi1NNrPCWW1KvlB6Q •  h:p://www.eid.ed.ac.uk/eid/sites/sbsweb2.bio.ed.ac.uk.eid/files/common/130502-­‐‑map-­‐‑and-­‐‑

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