Appendix C. Included articles

Author(s) Title JournalAbdel-Wahab M, Mehilli J, Frerker C, Neumann FJ,

Kurz T, Tolg R, Zachow D, Guerra E, Massberg S, Schafer U, El-Mawardy M, Richardt G; CHOICE

investigators.

Comparison of balloon-expandable vs self-expandable valves in patients undergoing

transcatheter aortic valve replacement: the CHOICE randomized clinical trial.

JAMA. 2014

Acker MA, Parides MK, Perrault LP, Moskowitz AJ, Gelijns AC, Voisine P, Smith PK, Hung JW,

Blackstone EH, Puskas JD, Argenziano M, Gammie JS, Mack M, Ascheim DD, Bagiella E, Moquete EG,

Ferguson TB, Horvath KA, Geller NL, Miller MA, Woo YJ, D'Alessandro DA, et al.

Mitral-valve repair versus replacement for severe ischemic mitral regurgitation. N Engl J Med. 2014

Adams DH, Popma JJ, Reardon MJ, Yakubov SJ, Coselli JS, Deeb GM, Gleason TG, Buchbinder M, Hermiller J Jr, Kleiman NS, Chetcuti S, Heiser J,

Merhi W, Zorn G, Tadros P, Robinson N, Petrossian G, Hughes GC, Harrison JK, Conte J,

Maini B, Mumtaz M, et al.

Transcatheter aortic-valve replacement with a self-expanding prosthesis. N Engl J Med. 2014

Allen PJ, Gonen M, Brennan MF, Bucknor AA, Robinson LM, Pappas MM, Carlucci KE, D'Angelica

MI, DeMatteo RP, Kingham TP, Fong Y, Jarnagin WR.

Pasireotide for postoperative pancreatic fistula. N Engl J Med. 2014

Allen RP, Chen C, Garcia-Borreguero D, Polo O, DuBrava S, Miceli J, Knapp L, Winkelman JW.

Comparison of pregabalin with pramipexole for restless legs syndrome. N Engl J Med. 2014

Amrein K, Schnedl C, Holl A, Riedl R, Christopher KB, Pachler C, Urbanic Purkart T, Waltensdorfer A,

Munch A, Warnkross H, Stojakovic T, Bisping E, Toller W, Smolle KH, Berghold A, Pieber TR,

Dobnig H.

Effect of high-dose vitamin D3 on hospital length of stay in critically ill patients with vitamin D

deficiency: the VITdAL-ICU randomized clinical trial.

JAMA. 2014

Anagnostou K, Islam S, King Y, Foley L, Pasea L, Bond S, Palmer C, Deighton J, Ewan P, Clark A.

Assessing the efficacy of oral immunotherapy for the desensitisation of peanut allergy in children (STOP II): a phase 2 randomised controlled trial.

Lancet. 2014

Anderson AS, Craigie AM, Caswell S, Treweek S, The impact of a bodyweight and physical activity BMJ. 2014

Stead M, Macleod M, Daly F, Belch J, Rodger J, Kirk A, Ludbrook A, Rauchhaus P, Norwood P,

Thompson J, Wardle J, Steele RJ.

intervention (BeWEL) initiated through a national colorectal cancer screening programme:

randomised controlled trial.ARISE Investigators; ANZICS Clinical Trials Group,

Peake SL, Delaney A, Bailey M, Bellomo R, Cameron PA, Cooper DJ, Higgins AM, Holdgate A,

Howe BD, Webb SA, Williams P.

Goal-directed resuscitation for patients with early septic shock. N Engl J Med. 2014

Asfar P, Meziani F, Hamel JF, Grelon F, Megarbane B, Anguel N, Mira JP, Dequin PF, Gergaud S, Weiss

N, Legay F, Le Tulzo Y, Conrad M, Robert R, Gonzalez F, Guitton C, Tamion F, Tonnelier JM,

Guezennec P, Van Der Linden T, Vieillard-Baron A, Mariotte E, et al.

High versus low blood-pressure target in patients with septic shock. N Engl J Med. 2014

Ashby RL, Gabe R, Ali S, Adderley U, Bland JM, Cullum NA, Dumville JC, Iglesias CP, Kang'ombe

AR, Soares MO, Stubbs NC, Torgerson DJ.

Clinical and cost-effectiveness of compression hosiery versus compression bandages in

treatment of venous leg ulcers (Venous leg Ulcer Study IV, VenUS IV): a randomised controlled trial.

Lancet. 2014

Azzopardi D, Strohm B, Marlow N, Brocklehurst P, Deierl A, Eddama O, Goodwin J, Halliday HL,

Juszczak E, Kapellou O, Levene M, Linsell L, Omar O, Thoresen M, Tusor N, Whitelaw A, Edwards AD;

TOBY Study Group.

Effects of hypothermia for perinatal asphyxia on childhood outcomes. N Engl J Med. 2014

Bakker OJ, van Brunschot S, van Santvoort HC, Besselink MG, Bollen TL, Boermeester MA, Dejong

CH, van Goor H, Bosscha K, Ahmed Ali U, Bouwense S, van Grevenstein WM, Heisterkamp J,

Houdijk AP, Jansen JM, Karsten TM, Manusama ER, Nieuwenhuijs VB, Schaapherder AF, van der Schelling GP, Schwartz MP, Spanier BW, et al.

Early versus on-demand nasoenteric tube feeding in acute pancreatitis. N Engl J Med. 2015

Barber MD, Brubaker L, Burgio KL, Richter HE, Nygaard I, Weidner AC, Menefee SA, Lukacz ES,

Norton P, Schaffer J, Nguyen JN, Borello-France D, Goode PS, Jakus-Waldman S, Spino C, Warren LK,

Gantz MG, Meikle SF; Eunice Kennedy Shriver

Comparison of 2 transvaginal surgical approaches and perioperative behavioral therapy for apical

vaginal prolapse: the OPTIMAL randomized trial.N Engl J Med. 2014

National Institute of Child Health and Human Development Pelvic Floor Disorders Network.

Bateman DN, Dear JW, Thanacoody HK, Thomas SH, Eddleston M, Sandilands EA, Coyle J, Cooper JG, Rodriguez A, Butcher I, Lewis SC, Vliegenthart

AD, Veiraiah A, Webb DJ, Gray A.

Reduction of adverse effects from intravenous acetylcysteine treatment for paracetamol poisoning: a randomised controlled trial.

JAMA. 2014

Bazzano LA, Hu T, Reynolds K, Yao L, Bunol C, Liu Y, Chen CS, Klag MJ, Whelton PK, He J.

Effects of low-carbohydrate and low-fat diets: a randomized trial. Lancet. 2014

Beck LA, Thaci D, Hamilton JD, Graham NM, Bieber T, Rocklin R, Ming JE, Ren H, Kao R,

Simpson E, Ardeleanu M, Weinstein SP, Pirozzi G, Guttman-Yassky E, Suárez-Fariñas M, Hager

MD, Stahl N, Yancopoulos GD, Radin AR.

Dupilumab treatment in adults with moderate-to-severe atopic dermatitis. Ann Intern Med. 2014

Beer TM, Armstrong AJ, Rathkopf DE, Loriot Y, Sternberg CN, Higano CS, Iversen P, Bhattacharya

S, Carles J, Chowdhury S, Davis ID, de Bono JS, Evans CP, Fizazi K, Joshua AM, Kim CS, Kimura G, Mainwaring P, Mansbach H, Miller K, Noonberg

SB, Perabo F, et al.

Enzalutamide in metastatic prostate cancer before chemotherapy. N Engl J Med. 2014

Bel EH, Wenzel SE, Thompson PJ, Prazma CM, Keene ON, Yancey SW, Ortega HG, Pavord ID;

SIRIUS Investigators.

Oral glucocorticoid-sparing effect of mepolizumab in eosinophilic asthma. N Engl J Med. 2014

Belshe RB, Frey SE, Graham IL, Anderson EL, Jackson LA, Spearman P, Edupuganti S, Mulligan

MJ, Rouphael N, Winokur P, Dolor RJ, Woods CW, Walter EB, Chen WH, Turley C, Edwards KM,

Creech CB, Hill H, Bellamy AR; National Institute of Allergy and Infectious Diseases–Funded Vaccine

and Treatment Evaluation Units.

Immunogenicity of avian influenza A/Anhui/01/2005(H5N1) vaccine with MF59

adjuvant: a randomized clinical trial.N Engl J Med. 2014

Benboubker L, Dimopoulos MA, Dispenzieri A, Catalano J, Belch AR, Cavo M, Pinto A, Weisel K,

Ludwig H, Bahlis N, Banos A, Tiab M, Delforge M, Cavenagh J, Geraldes C, Lee JJ, Chen C, Oriol A, de

la Rubia J, Qiu L, White DJ, Binder D, et al.

Lenalidomide and dexamethasone in transplant-ineligible patients with myeloma. JAMA. 2014

Benjamin DK Jr, Hudak ML, Duara S, Randolph DA, Bidegain M, Mundakel GT, Natarajan G, Burchfield DJ, White RD, Shattuck KE, Neu N, Bendel CM, Kim

MR, Finer NN, Stewart DL, Arrieta AC, Wade KC, Kaufman DA, Manzoni P, Prather KO, Testoni D,

Berezny KY, et al.

Effect of fluconazole prophylaxis on candidiasis and mortality in premature infants: a randomized

clinical trial.N Engl J Med. 2014

Bennell KL, Egerton T, Martin J, Abbott JH, Metcalf B, McManus F, Sims K, Pua YH, Wrigley TV, Forbes

A, Smith C, Harris A, Buchbinder R.

Effect of physical therapy on pain and function in patients with hip osteoarthritis: a randomized

clinical trial.JAMA. 2014

Berkhemer OA, Fransen PS, Beumer D, van den Berg LA, Lingsma HF, Yoo AJ, Schonewille WJ, Vos JA, Nederkoorn PJ, Wermer MJ, van Walderveen

MA, Staals J, Hofmeijer J, van Oostayen JA, Lycklama à Nijeholt GJ, Boiten J, Brouwer PA,

Emmer BJ, de Bruijn SF, van Dijk LC, Kappelle LJ, Lo RH, et al.

A randomized trial of intraarterial treatment for acute ischemic stroke. JAMA. 2014

Berlin I, Grange G, Jacob N, Tanguy ML.Nicotine patches in pregnant smokers:

randomised, placebo controlled, multicentre trial of efficacy.

N Engl J Med. 2015

Bezerra JA, Spino C, Magee JC, Shneider BL, Rosenthal P, Wang KS, Erlichman J, Haber B, Hertel PM, Karpen SJ, Kerkar N, Loomes KM,

Molleston JP, Murray KF, Romero R, Schwarz KB, Shepherd R, Suchy FJ, Turmelle YP, Whitington PF,

Moore J, Sherker AH, et al.

Use of corticosteroids after hepatoportoenterostomy for bile drainage in

infants with biliary atresia: the START randomized clinical trial.

BMJ. 2014

Bhandari N, Rongsen-Chandola T, Bavdekar A, John J, Antony K, Taneja S, Goyal N, Kawade A, Kang G, Rathore SS, Juvekar S, Muliyil J, Arya A,

Shaikh H, Abraham V, Vrati S, Proschan M, Kohberger R, Thiry G, Glass R, Greenberg HB,

Curlin G, et al.

Efficacy of a monovalent human-bovine (116E) rotavirus vaccine in Indian infants: a randomised,

double-blind, placebo-controlled trial.JAMA. 2014

Bhatt DL, Kandzari DE, O'Neill WW, D'Agostino R, Flack JM, Katzen BT, Leon MB, Liu M, Mauri L, Negoita M, Cohen SA, Oparil S, Rocha-Singh K,

Townsend RR, Bakris GL; SYMPLICITY HTN-3 Investigators.

A controlled trial of renal denervation for resistant hypertension. Lancet. 2014

Bill-Axelson A, Holmberg L, Garmo H, Rider JR, Taari K, Busch C, Nordling S, Haggman M,

Andersson SO, Spangberg A, Andren O, Palmgren J, Steineck G, Adami HO, Johansson JE.

Radical prostatectomy or watchful waiting in early prostate cancer. N Engl J Med. 2014

Blom DJ, Hala T, Bolognese M, Lillestol MJ, Toth PD, Burgess L, Ceska R, Roth E, Koren MJ,

Ballantyne CM, Monsalvo ML, Tsirtsonis K, Kim JB, Scott R, Wasserman SM, Stein EA; DESCARTES

Investigators.

A 52-week placebo-controlled trial of evolocumab in hyperlipidemia. N Engl J Med. 2014

Boucher HW, Wilcox M, Talbot GH, Puttagunta S, Das AF, Dunne MW.

Once-weekly dalbavancin versus daily conventional therapy for skin infection. N Engl J Med. 2014

Boulware DR, Meya DB, Muzoora C, Rolfes MA, Huppler Hullsiek K, Musubire A, Taseera K, Nabeta HW, Schutz C, Williams DA, Rajasingham R, Rhein J, Thienemann F, Lo MW, Nielsen K, Bergemann TL, Kambugu A, Manabe YC, Janoff EN, Bohjanen

PR, Meintjes G; COAT Trial Team.

Timing of antiretroviral therapy after diagnosis of cryptococcal meningitis. N Engl J Med. 2014

Bove T, Zangrillo A, Guarracino F, Alvaro G, Persi B, Maglioni E, Galdieri N, Comis M, Caramelli F,

Pasero DC, Pala G, Renzini M, Conte M, Paternoster G, Martinez B, Pinelli F, Frontini M,

Zucchetti MC, Pappalardo F, Amantea B, Camata A, Pisano A, et al.

Effect of fenoldopam on use of renal replacement therapy among patients with acute kidney injury after cardiac surgery: a randomized clinical trial.

N Engl J Med. 2014

Bowen AC, Tong SY, Andrews RM, O'Meara IM, McDonald MI, Chatfield MD, Currie BJ, Carapetis

JR.

Short-course oral co-trimoxazole versus intramuscular benzathine benzylpenicillin for impetigo in a highly endemic region: an open-

label, randomised, controlled, non-inferiority trial.

JAMA. 2014

Brar SS, Aharonian V, Mansukhani P, Moore N, Shen AY, Jorgensen M, Dua A, Short L, Kane K.

Haemodynamic-guided fluid administration for the prevention of contrast-induced acute kidney

injury: the POSEIDON randomised controlled trial.Lancet. 2014

Brittenden J, Cotton SC, Elders A, Ramsay CR, Norrie J, Burr J, Campbell B, Bachoo P, Chetter I, Gough M, Earnshaw J, Lees T, Scott J, Baker SA,

Francis J, Tassie E, Scotland G, Wileman S, Campbell MK.

A randomized trial comparing treatments for varicose veins. Lancet. 2014

Bronfort G, Hondras MA, Schulz CA, Evans RL, Long CR, Grimm R.

Spinal manipulation and home exercise with advice for subacute and chronic back-related leg

pain: a trial with adaptive allocation.N Engl J Med. 2014

Brose MS, Nutting CM, Jarzab B, Elisei R, Siena S, Bastholt L, de la Fouchardiere C, Pacini F, Paschke

R, Shong YK, Sherman SI, Smit JW, Chung J, Kappeler C, Pena C, Molnar I, Schlumberger MJ;

DECISION investigators.

Sorafenib in radioactive iodine-refractory, locally advanced or metastatic differentiated thyroid

cancer: a randomised, double-blind, phase 3 trial.Ann Intern Med. 2014

Bwakura-Dangarembizi M, Kendall L, Bakeera-Kitaka S, Nahirya-Ntege P, Keishanyu R, Nathoo K,

Spyer MJ, Kekitiinwa A, Lutaakome J, Mhute T, Kasirye P, Munderi P, Musiime V, Gibb DM, Walker AS, Prendergast AJ; Antiretroviral

Research for Watoto (ARROW) Trial Team.

A randomized trial of prolonged co-trimoxazole in HIV-infected children in Africa. Lancet. 2014

Byrd JC, Brown JR, O'Brien S, Barrientos JC, Kay NE, Reddy NM, Coutre S, Tam CS, Mulligan SP,

Jaeger U, Devereux S, Barr PM, Furman RR, Kipps TJ, Cymbalista F, Pocock C, Thornton P, Caligaris-

Cappio F, Robak T, Delgado J, Schuster SJ, Montillo M, et al.

Ibrutinib versus ofatumumab in previously treated chronic lymphoid leukemia. N Engl J Med. 2014

Caironi P, Tognoni G, Masson S, Fumagalli R, Pesenti A, Romero M, Fanizza C, Caspani L, Faenza S, Grasselli G, Iapichino G, Antonelli M, Parrini V,

Fiore G, Latini R, Gattinoni L; ALBIOS Study

Albumin replacement in patients with severe sepsis or septic shock.

N Engl J Med. 2014

Investigators.Capeding MR, Tran NH, Hadinegoro SR, Ismail HI,

Chotpitayasunondh T, Chua MN, Luong CQ, Rusmil K, Wirawan DN, Nallusamy R, Pitisuttithum P,

Thisyakorn U, Yoon IK, van der Vliet D, Langevin E, Laot T, Hutagalung Y, Frago C, Boaz M, Wartel TA,

Tornieporth NG, Saville M, et al.

Clinical efficacy and safety of a novel tetravalent dengue vaccine in healthy children in Asia: a

phase 3, randomised, observer-masked, placebo-controlled trial.

N Engl J Med. 2014

Caplin ME, Pavel M, Cwikla JB, Phan AT, Raderer M, Sedlackova E, Cadiot G, Wolin EM, Capdevila J, Wall L, Rindi G, Langley A, Martinez S, Blumberg J,

Ruszniewski P; CLARINET Investigators.

Lanreotide in metastatic enteropancreatic neuroendocrine tumors. Lancet. 2014

Carvajal RD, Sosman JA, Quevedo JF, Milhem MM, Joshua AM, Kudchadkar RR, Linette GP, Gajewski

TF, Lutzky J, Lawson DH, Lao CD, Flynn PJ, Albertini MR, Sato T, Lewis K, Doyle A, Ancell K,

Panageas KS, Bluth M, Hedvat C, Erinjeri J, Ambrosini G, et al.

Effect of selumetinib vs chemotherapy on progression-free survival in uveal melanoma: a

randomized clinical trial.N Engl J Med. 2014

Castro M, King TS, Kunselman SJ, Cabana MD, Denlinger L, Holguin F, Kazani SD, Moore WC, Moy

J, Sorkness CA, Avila P, Bacharier LB, Bleecker E, Boushey HA, Chmiel J, Fitzpatrick AM, Gentile D, Hundal M, Israel E, Kraft M, Krishnan JA, LaForce

C, et al.

Effect of vitamin D3 on asthma treatment failures in adults with symptomatic asthma and lower vitamin D levels: the VIDA randomized clinical

trial.

JAMA. 2014

Chamberlain JM, Okada P, Holsti M, Mahajan P, Brown KM, Vance C, Gonzalez V, Lichenstein R,

Stanley R, Brousseau DC, Grubenhoff J, Zemek R, Johnson DW, Clemons TE, Baren J; Pediatric Emergency Care Applied Research Network

(PECARN).

Lorazepam vs diazepam for pediatric status epilepticus: a randomized clinical trial. JAMA. 2014

Chan JC, Sui Y, Oldenburg B, Zhang Y, Chung HH, Goggins W, Au S, Brown N, Ozaki R, Wong RY, Ko

GT, Fisher E; JADE and PEARL Project Team.

Effects of telephone-based peer support in patients with type 2 diabetes mellitus receiving

integrated care: a randomized clinical trial.JAMA. 2014

Chataway J, Schuerer N, Alsanousi A, Chan D, MacManus D, Hunter K, Anderson V, Bangham CR, Clegg S, Nielsen C, Fox NC, Wilkie D, Nicholas JM,

Calder VL, Greenwood J, Frost C, Nicholas R.

Effect of high-dose simvastatin on brain atrophy and disability in secondary progressive multiple

sclerosis (MS-STAT): a randomised, placebo-controlled, phase 2 trial.

JAMA Intern Med. 2014

Chatterjee S, Naik S, John S, Dabholkar H, Balaji M, Koschorke M, Varghese M, Thara R, Weiss HA, Williams P, McCrone P, Patel V, Thornicroft G.

Effectiveness of a community-based intervention for people with schizophrenia and their caregivers

in India (COPSI): a randomised controlled trial.Lancet. 2014

Chemaly RF, Ullmann AJ, Stoelben S, Richard MP, Bornhauser M, Groth C, Einsele H, Silverman M,

Mullane KM, Brown J, Nowak H, Kolling K, Stobernack HP, Lischka P, Zimmermann H,

Rübsamen-Schaeff H, Champlin RE, Ehninger G; AIC246 Study Team.

Letermovir for cytomegalovirus prophylaxis in hematopoietic-cell transplantation. Lancet. 2014

Chetchotisakd P, Chierakul W, Chaowagul W, Anunnatsiri S, Phimda K, Mootsikapun P, Chaisuksant S, Pilaikul J, Thinkhamrop B,

Phiphitaporn S, Susaengrat W, Toondee C, Wongrattanacheewin S, Wuthiekanun V,

Chantratita N, Thaipadungpanit J, Day NP, Limmathurotsakul D, Peacock SJ.

Trimethoprim-sulfamethoxazole versus trimethoprim-sulfamethoxazole plus doxycycline

as oral eradicative treatment for melioidosis (MERTH): a multicentre, double-blind, non-

inferiority, randomised controlled trial.

N Engl J Med. 2014

Chey WD, Webster L, Sostek M, Lappalainen J, Barker PN, Tack J.

Naloxegol for opioid-induced constipation in patients with noncancer pain. Lancet. 2014

Chinot OL, Wick W, Mason W, Henriksson R, Saran F, Nishikawa R, Carpentier AF, Hoang-Xuan K,

Kavan P, Cernea D, Brandes AA, Hilton M, Abrey L, Cloughesy T.

Bevacizumab plus radiotherapy-temozolomide for newly diagnosed glioblastoma. N Engl J Med. 2014

Chirinos JA, Gurubhagavatula I, Teff K, Rader DJ, Wadden TA, Townsend R, Foster GD, Maislin G,

Saif H, Broderick P, Chittams J, Hanlon AL, Pack AI.

CPAP, weight loss, or both for obstructive sleep apnea. N Engl J Med. 2014

Clotet B, Feinberg J, van Lunzen J, Khuong-Josses MA, Antinori A, Dumitru I, Pokrovskiy V, Fehr J, Ortiz R, Saag M, Harris J, Brennan C, Fujiwara T,

Min S; ING114915 Study Team.

Once-daily dolutegravir versus darunavir plus ritonavir in antiretroviral-naive adults with HIV-1 infection (FLAMINGO): 48 week results from the

randomised open-label phase 3b study.

N Engl J Med. 2014

Cohen A, Assyag P, Boyer-Chatenet L, Cohen-Solal A, Perdrix C, Dalichampt M, Michel PL,

Montalescot G, Ravaud P, Steg PG, Boutron I; Reseau Insuffisance Cardiaque (RESICARD)

PREVENTION Investigators.

An education program for risk factor management after an acute coronary syndrome: a randomized

clinical trial.Lancet. 2014

Cooper CJ, Murphy TP, Cutlip DE, Jamerson K, Henrich W, Reid DM, Cohen DJ, Matsumoto AH,

Steffes M, Jaff MR, Prince MR, Lewis EF, Tuttle KR, Shapiro JI, Rundback JH, Massaro JM, D'Agostino

RB Sr, Dworkin LD; CORAL Investigators.

Stenting and medical therapy for atherosclerotic renal-artery stenosis. JAMA Intern Med. 2014

Corey GR, Kabler H, Mehra P, Gupta S, Overcash JS, Porwal A, Giordano P, Lucasti C, Perez A, Good

S, Jiang H, Moeck G, O'Riordan W; SOLO I Investigators.

Single-dose oritavancin in the treatment of acute bacterial skin infections. N Engl J Med. 2014

Costa ML, Achten J, Parsons NR, Rangan A, Griffin D, Tubeuf S, Lamb SE; DRAFFT Study Group.

Percutaneous fixation with Kirschner wires versus volar locking plate fixation in adults with dorsally

displaced fracture of distal radius: randomised controlled trial.

N Engl J Med. 2014

Cotton PB, Durkalski V, Romagnuolo J, Pauls Q, Fogel E, Tarnasky P, Aliperti G, Freeman M, Kozarek R, Jamidar P, Wilcox M, Serrano J,

Brawman-Mintzer O, Elta G, Mauldin P, Thornhill A, Hawes R, Wood-Williams A, Orrell K, Drossman

D, Robuck P.

Effect of endoscopic sphincterotomy for suspected sphincter of Oddi dysfunction on pain-related disability following cholecystectomy: the

EPISOD randomized clinical trial.

BMJ. 2014

Criner GJ, Connett JE, Aaron SD, Albert RK, Bailey WC, Casaburi R, Cooper JA Jr, Curtis JL, Dransfield MT, Han MK, Make B, Marchetti N, Martinez FJ, Niewoehner DE, Scanlon PD, Sciurba FC, Scharf

Simvastatin for the prevention of exacerbations in moderate-to-severe COPD. JAMA. 2014

SM, Sin DD, Voelker H, Washko GR, Woodruff PG, Lazarus SC; et al.

Cummings J, Isaacson S, Mills R, Williams H, Chi-Burris K, Corbett A, Dhall R, Ballard C.

Pimavanserin for patients with Parkinson's disease psychosis: a randomised, placebo-

controlled phase 3 trial.N Engl J Med. 2014

Cuzick J, Sestak I, Forbes JF, Dowsett M, Knox J, Cawthorn S, Saunders C, Roche N, Mansel RE, von Minckwitz G, Bonanni B, Palva T, Howell A; IBIS-II

investigators.

Anastrozole for prevention of breast cancer in high-risk postmenopausal women (IBIS-II): an

international, double-blind, randomised placebo-controlled trial.

Lancet. 2014

De Bruyne B, Fearon WF, Pijls NH, Barbato E, Tonino P, Piroth Z, Jagic N, Mobius-Winckler S,

Rioufol G, Witt N, Kala P, MacCarthy P, Engstrom T, Oldroyd K, Mavromatis K, Manoharan G, Verlee

P, Frobert O, Curzen N, Johnson JB, Limacher A, Nüesch E, et al.

Fractional flow reserve-guided PCI for stable coronary artery disease. Lancet. 2014

DeBaun MR, Gordon M, McKinstry RC, Noetzel MJ, White DA, Sarnaik SA, Meier ER, Howard TH, Majumdar S, Inusa BP, Telfer PT, Kirby-Allen M, McCavit TL, Kamdem A, Airewele G, Woods GM, Berman B, Panepinto JA, Fuh BR, Kwiatkowski JL,

King AA, Fixler JM, et al.

Controlled trial of transfusions for silent cerebral infarcts in sickle cell anemia. N Engl J Med. 2014

Derdeyn CP, Chimowitz MI, Lynn MJ, Fiorella D, Turan TN, Janis LS, Montgomery J, Nizam A, Lane BF, Lutsep HL, Barnwell SL, Waters MF, Hoh BL, Hourihane JM, Levy EI, Alexandrov AV, Harrigan

MR, Chiu D, Klucznik RP, Clark JM, McDougall CG, Johnson MD, et al.

Aggressive medical treatment with or without stenting in high-risk patients with intracranial

artery stenosis (SAMMPRIS): the final results of a randomised trial.

N Engl J Med. 2014

Devauchelle-Pensec V, Mariette X, Jousse-Joulin S, Berthelot JM, Perdriger A, Puechal X, Le Guern V,

Sibilia J, Gottenberg JE, Chiche L, Hachulla E, Hatron PY, Goeb V, Hayem G, Morel J, Zarnitsky C,

Dubost JJ, Pers JO, Nowak E, Saraux A.

Treatment of primary Sjogren syndrome with rituximab: a randomized trial. Lancet. 2014

Devereaux PJ, Mrkobrada M, Sessler DI, Leslie K, Alonso-Coello P, Kurz A, Villar JC, Sigamani A, Biccard BM, Meyhoff CS, Parlow JL, Guyatt G,

Robinson A, Garg AX, Rodseth RN, Botto F, Lurati Buse G, Xavier D, Chan MT, Tiboni M, Cook D,

Kumar PA, et al.

Aspirin in patients undergoing noncardiac surgery. Ann Intern Med. 2014

Devereaux PJ, Sessler DI, Leslie K, Kurz A, Mrkobrada M, Alonso-Coello P, Villar JC, Sigamani

A, Biccard BM, Meyhoff CS, Parlow JL, Guyatt G, Robinson A, Garg AX, Rodseth RN, Botto F, Lurati

Buse G, Xavier D, Chan MT, Tiboni M, Cook D, Kumar PA, et al.

Clonidine in patients undergoing noncardiac surgery. N Engl J Med. 2014

DeVincenzo JP, Whitley RJ, Mackman RL, Scaglioni-Weinlich C, Harrison L, Farrell E, McBride

S, Lambkin-Williams R, Jordan R, Xin Y, Ramanathan S, O'Riordan T, Lewis SA, Li X, Toback

SL, Lin SL, Chien JW.

Oral GS-5806 activity in a respiratory syncytial virus challenge study. N Engl J Med. 2014

Dhalla IA, O'Brien T, Morra D, Thorpe KE, Wong BM, Mehta R, Frost DW, Abrams H, Ko F, Van

Rooyen P, Bell CM, Gruneir A, Lewis GH, Daub S, Anderson GM, Hawker GA, Rochon PA, Laupacis

A.

Effect of a postdischarge virtual ward on readmission or death for high-risk patients: a

randomized clinical trial.N Engl J Med. 2014

Diacon AH, Pym A, Grobusch MP, de los Rios JM, Gotuzzo E, Vasilyeva I, Leimane V, Andries K, Bakare N, De Marez T, Haxaire-Theeuwes M,

Lounis N, Meyvisch P, De Paepe E, van Heeswijk RP, Dannemann B; TMC207-C208 Study Group.

Multidrug-resistant tuberculosis and culture conversion with bedaquiline. JAMA. 2014

DiazGranados CA, Dunning AJ, Kimmel M, Kirby D, Treanor J, Collins A, Pollak R, Christoff J, Earl J, Landolfi V, Martin E, Gurunathan S, Nathan R, Greenberg DP, Tornieporth NG, Decker MD,

Talbot HK.

Efficacy of high-dose versus standard-dose influenza vaccine in older adults. N Engl J Med. 2014

Diener MK, Knebel P, Kieser M, Schuler P, Schiergens TS, Atanassov V, Neudecker J, Stein E,

Thielemann H, Kunz R, von Frankenberg M, Schernikau U, Bunse J, Jansen-Winkeln B, Partecke LI, Prechtl G, Pochhammer J, Bouchard R, Hodina

R, Beckurts KT, Leißner L, Lemmens HP, et al.

Effectiveness of triclosan-coated PDS Plus versus uncoated PDS II sutures for prevention of surgical

site infection after abdominal wall closure: the randomised controlled PROUD trial.

N Engl J Med. 2014

Dodd JM, Turnbull D, McPhee AJ, Deussen AR, Grivell RM, Yelland LN, Crowther CA, Wittert G, Owens JA, Robinson JS; LIMIT Randomised Trial

Group.

Antenatal lifestyle advice for women who are overweight or obese: LIMIT randomised trial. Lancet. 2014

Doody RS, Thomas RG, Farlow M, Iwatsubo T, Vellas B, Joffe S, Kieburtz K, Raman R, Sun X, Aisen PS, Siemers E, Liu-Seifert H, Mohs R; Alzheimer's Disease Cooperative Study Steering Committee;

Solanezumab Study Group.

Phase 3 trials of solanezumab for mild-to-moderate Alzheimer's disease. BMJ. 2014

Dungan KM, Povedano ST, Forst T, Gonzalez JG, Atisso C, Sealls W, Fahrbach JL.

Once-weekly dulaglutide versus once-daily liraglutide in metformin-treated patients with

type 2 diabetes (AWARD-6): a randomised, open-label, phase 3, non-inferiority trial.

N Engl J Med. 2014

Dysken MW, Sano M, Asthana S, Vertrees JE, Pallaki M, Llorente M, Love S, Schellenberg GD,

McCarten JR, Malphurs J, Prieto S, Chen P, Loreck DJ, Trapp G, Bakshi RS, Mintzer JE, Heidebrink JL,

Vidal-Cardona A, Arroyo LM, Cruz AR, Zachariah S, Kowall NW, et al.

Effect of vitamin E and memantine on functional decline in Alzheimer disease: the TEAM-AD VA

cooperative randomized trial.Lancet. 2014

Ebbert JO, Hatsukami DK, Croghan IT, Schroeder DR, Allen SS, Hays JT, Hurt RD.

Combination varenicline and bupropion SR for tobacco-dependence treatment in cigarette

smokers: a randomized trial.JAMA. 2014

Ebinger M, Winter B, Wendt M, Weber JE, Waldschmidt C, Rozanski M, Kunz A, Koch P,

Kellner PA, Gierhake D, Villringer K, Fiebach JB, Grittner U, Hartmann A, Mackert BM, Endres M,

Audebert HJ; STEMO Consortium.

Effect of the use of ambulance-based thrombolysis on time to thrombolysis in acute

ischemic stroke: a randomized clinical trial.JAMA. 2014

Emery P, Hammoudeh M, FitzGerald O, Combe B, Martin-Mola E, Buch MH, Krogulec M, Williams T,

Gaylord S, Pedersen R, Bukowski J, Vlahos B.

Sustained remission with etanercept tapering in early rheumatoid arthritis. JAMA. 2014

ENCORE1 Study Group, Puls R, Amin J, Losso M, Phanuphak P, Nwizu C, Orrell C, Young B, Shahar E, Wolff M, Gazzard B, Read T, Hill A, Cooper DA,

Emery S.

Efficacy of 400 mg efavirenz versus standard 600 mg dose in HIV-infected, antiretroviral-naive

adults (ENCORE1): a randomised, double-blind, placebo-controlled, non-inferiority trial.

N Engl J Med. 2014

Evins AE, Cather C, Pratt SA, Pachas GN, Hoeppner SS, Goff DC, Achtyes ED, Ayer D, Schoenfeld DA.

Maintenance treatment with varenicline for smoking cessation in patients with schizophrenia and bipolar disorder: a randomized clinical trial.

Lancet. 2014

Feld JJ, Kowdley KV, Coakley E, Sigal S, Nelson DR, Crawford D, Weiland O, Aguilar H, Xiong J, Pilot-

Matias T, DaSilva-Tillmann B, Larsen L, Podsadecki T, Bernstein B.

Treatment of HCV with ABT-450/r-ombitasvir and dasabuvir with ribavirin. JAMA. 2014

Ferenci P, Bernstein D, Lalezari J, Cohen D, Luo Y, Cooper C, Tam E, Marinho RT, Tsai N, Nyberg A, Box TD, Younes Z, Enayati P, Green S, Baruch Y, Bhandari BR, Caruntu FA, Sepe T, Chulanov V,

Janczewska E, Rizzardini G, Gervain J, et al.

ABT-450/r-ombitasvir and dasabuvir with or without ribavirin for HCV. N Engl J Med. 2014

Fox K, Ford I, Steg PG, Tardif JC, Tendera M, Ferrari R; SIGNIFY Investigators.

Ivabradine in stable coronary artery disease without clinical heart failure. N Engl J Med. 2014

Francis PA, Regan MM, Fleming GF, Lang I, Ciruelos E, Bellet M, Bonnefoi HR, Climent MA, Da

Prada GA, Burstein HJ, Martino S, Davidson NE, Geyer CE Jr, Walley BA, Coleman R, Kerbrat P,

Buchholz S, Ingle JN, Winer EP, Rabaglio-Poretti M, Maibach R, Ruepp B, et al.

Adjuvant ovarian suppression in premenopausal breast cancer. N Engl J Med. 2014

Friedly JL, Comstock BA, Turner JA, Heagerty PJ, Deyo RA, Sullivan SD, Bauer Z, Bresnahan BW,

Avins AL, Nedeljkovic SS, Nerenz DR, Standaert C, Kessler L, Akuthota V, Annaswamy T, Chen A,

Diehn F, Firtch W, Gerges FJ, Gilligan C, Goldberg H, Kennedy DJ, et al.

A randomized trial of epidural glucocorticoid injections for spinal stenosis. N Engl J Med. 2015

Fu SS, van Ryn M, Sherman SE, Burgess DJ, Proactive tobacco treatment and population-level N Engl J Med. 2014

Noorbaloochi S, Clothier B, Taylor BC, Schlede CM, Burke RS, Joseph AM. cessation: a pragmatic randomized clinical trial.

Fuchs CS, Tomasek J, Yong CJ, Dumitru F, Passalacqua R, Goswami C, Safran H, dos Santos

LV, Aprile G, Ferry DR, Melichar B, Tehfe M, Topuzov E, Zalcberg JR, Chau I, Campbell W,

Sivanandan C, Pikiel J, Koshiji M, Hsu Y, Liepa AM, Gao L, et al.

Ramucirumab monotherapy for previously treated advanced gastric or gastro-oesophageal junction

adenocarcinoma (REGARD): an international, randomised, multicentre, placebo-controlled,

phase 3 trial.

JAMA Intern Med. 2014

Furman RR, Sharman JP, Coutre SE, Cheson BD, Pagel JM, Hillmen P, Barrientos JC, Zelenetz AD,

Kipps TJ, Flinn I, Ghia P, Eradat H, Ervin T, Lamanna N, Coiffier B, Pettitt AR, Ma S,

Stilgenbauer S, Cramer P, Aiello M, Johnson DM, Miller LL, et al.

Idelalisib and rituximab in relapsed chronic lymphocytic leukemia. Lancet. 2014

Garon EB, Ciuleanu TE, Arrieta O, Prabhash K, Syrigos KN, Goksel T, Park K, Gorbunova V,

Kowalyszyn RD, Pikiel J, Czyzewicz G, Orlov SV, Lewanski CR, Thomas M, Bidoli P, Dakhil S, Gans S,

Kim JH, Grigorescu A, Karaseva N, Reck M, Cappuzzo F, et al.

Ramucirumab plus docetaxel versus placebo plus docetaxel for second-line treatment of stage IV

non-small-cell lung cancer after disease progression on platinum-based therapy (REVEL): a

multicentre, double-blind, randomised phase 3 trial.

N Engl J Med. 2014

Gauvreau GM, O'Byrne PM, Boulet LP, Wang Y, Cockcroft D, Bigler J, FitzGerald JM, Boedigheimer M, Davis BE, Dias C, Gorski KS, Smith L, Bautista E,

Comeau MR, Leigh R, Parnes JR.

Effects of an anti-TSLP antibody on allergen-induced asthmatic responses. Lancet. 2014

Gilbert MR, Dignam JJ, Armstrong TS, Wefel JS, Blumenthal DT, Vogelbaum MA, Colman H,

Chakravarti A, Pugh S, Won M, Jeraj R, Brown PD, Jaeckle KA, Schiff D, Stieber VW, Brachman DG,

Werner-Wasik M, Tremont-Lukats IW, Sulman EP, Aldape KD, Curran WJ Jr, Mehta MP.

A randomized trial of bevacizumab for newly diagnosed glioblastoma. N Engl J Med. 2014

Giles TD, Weber MA, Basile J, Gradman AH, Bharucha DB, Chen W, Pattathil M; NAC-MD-01

Study Investigators.

Efficacy and safety of nebivolol and valsartan as fixed-dose combination in hypertension: a

randomised, multicentre study.N Engl J Med. 2014

Gillespie SH, Crook AM, McHugh TD, Mendel CM, Four-month moxifloxacin-based regimens for Lancet. 2014

Meredith SK, Murray SR, Pappas F, Phillips PP, Nunn AJ; REMoxTB Consortium. drug-sensitive tuberculosis.

Gladstone DJ, Spring M, Dorian P, Panzov V, Thorpe KE, Hall J, Vaid H, O'Donnell M, Laupacis A, Cote R, Sharma M, Blakely JA, Shuaib A, Hachinski

V, Coutts SB, Sahlas DJ, Teal P, Yip S, Spence JD, Buck B, Verreault S, Casaubon LK, et al.

Atrial fibrillation in patients with cryptogenic stroke. N Engl J Med. 2014

Goede V, Fischer K, Busch R, Engelke A, Eichhorst B, Wendtner CM, Chagorova T, de la Serna J,

Dilhuydy MS, Illmer T, Opat S, Owen CJ, Samoylova O, Kreuzer KA, Stilgenbauer S,

Döhner H, Langerak AW, Ritgen M, Kneba M, Asikanius E, Humphrey K, Wenger M, et al.

Obinutuzumab plus chlorambucil in patients with CLL and coexisting conditions. N Engl J Med. 2014

Goldman LE, Sarkar U, Kessell E, Guzman D, Schneidermann M, Pierluissi E, Walter B,

Vittinghoff E, Critchfield J, Kushel M.

Support from hospital to home for elders: a randomized trial. N Engl J Med. 2014

Gottenberg JE, Ravaud P, Puechal X, Le Guern V, Sibilia J, Goeb V, Larroche C, Dubost JJ, Rist S,

Saraux A, Devauchelle-Pensec V, Morel J, Hayem G, Hatron P, Perdriger A, Sene D, Zarnitsky C,

Batouche D, Furlan V, Benessiano J, Perrodeau E, Seror R, et al.

Effects of hydroxychloroquine on symptomatic improvement in primary Sjogren syndrome: the

JOQUER randomized clinical trial.Ann Intern Med. 2014

Gottlieb DJ, Punjabi NM, Mehra R, Patel SR, Quan SF, Babineau DC, Tracy RP, Rueschman M,

Blumenthal RS, Lewis EF, Bhatt DL, Redline S.CPAP versus oxygen in obstructive sleep apnea. JAMA. 2014

Greening NJ, Williams JE, Hussain SF, Harvey-Dunstan TC, Bankart MJ, Chaplin EJ, Vincent EE, Chimera R, Morgan MD, Singh SJ, Steiner MC.

An early rehabilitation intervention to enhance recovery during hospital admission for an

exacerbation of chronic respiratory disease: randomised controlled trial.

N Engl J Med. 2014

Griffin D, Parsons N, Shaw E, Kulikov Y, Hutchinson C, Thorogood M, Lamb SE; UK Heel Fracture Trial

Investigators.

Operative versus non-operative treatment for closed, displaced, intra-articular fractures of the

calcaneus: randomised controlled trial.BMJ. 2014

Guillevin L, Pagnoux C, Karras A, Khouatra C, Aumaitre O, Cohen P, Maurier F, Decaux O, Ninet

Rituximab versus azathioprine for maintenance in ANCA-associated vasculitis. BMJ. 2014

J, Gobert P, Quemeneur T, Blanchard-Delaunay C, Godmer P, Puechal X, Carron PL, Hatron PY, Limal

N, Hamidou M, Ducret M, Daugas E, Papo T, Bonnotte B, et al.

Hagen S, Stark D, Glazener C, Dickson S, Barry S, Elders A, Frawley H, Galea MP, Logan J, McDonald

A, McPherson G, Moore KH, Norrie J, Walker A, Wilson D; POPPY Trial Collaborators.

Individualised pelvic floor muscle training in women with pelvic organ prolapse (POPPY): a

multicentre randomised controlled trial.N Engl J Med. 2014

Harman SM, Black DM, Naftolin F, Brinton EA, Budoff MJ, Cedars MI, Hopkins PN, Lobo RA,

Manson JE, Merriam GR, Miller VM, Neal-Perry G, Santoro N, Taylor HS, Vittinghoff E, Yan M, Hodis

HN.

Arterial imaging outcomes and cardiovascular risk factors in recently menopausal women: a

randomized trial.Lancet. 2014

Harvey SE, Parrott F, Harrison DA, Bear DE, Segaran E, Beale R, Bellingan G, Leonard R,

Mythen MG, Rowan KM; CALORIES Trial Investigators.

Trial of the route of early nutritional support in critically ill adults. Ann Intern Med. 2014

He J, Zhang Y, Xu T, Zhao Q, Wang D, Chen CS, Tong W, Liu C, Xu T, Ju Z, Peng Y, Peng H, Li Q,

Geng D, Zhang J, Li D, Zhang F, Guo L, Sun Y, Wang X, Cui Y, Li Y, et al.

Effects of immediate blood pressure reduction on death and major disability in patients with acute ischemic stroke: the CATIS randomized clinical

trial.

N Engl J Med. 2014

Heldman AW, DiFede DL, Fishman JE, Zambrano JP, Trachtenberg BH, Karantalis V, Mushtaq M,

Williams AR, Suncion VY, McNiece IK, Ghersin E, Soto V, Lopera G, Miki R, Willens H, Hendel R,

Mitrani R, Pattany P, Feigenbaum G, Oskouei B, Byrnes J, Lowery MH, et al.

Transendocardial mesenchymal stem cells and mononuclear bone marrow cells for ischemic

cardiomyopathy: the TAC-HFT randomized trial.JAMA. 2014

Herpertz-Dahlmann B, Schwarte R, Krei M, Egberts K, Warnke A, Wewetzer C, Pfeiffer E,

Fleischhaker C, Scherag A, Holtkamp K, Hagenah U, Buhren K, Konrad K, Schmidt U, Schade-

Brittinger C, Timmesfeld N, Dempfle A.

Day-patient treatment after short inpatient care versus continued inpatient treatment in

adolescents with anorexia nervosa (ANDI): a multicentre, randomised, open-label, non-

inferiority trial.

JAMA. 2014

Hindricks G, Taborsky M, Glikson M, Heinrich U, Schumacher B, Katz A, Brachmann J, Lewalter T,

Implant-based multiparameter telemonitoring of patients with heart failure (IN-TIME): a Lancet. 2014

Goette A, Block M, Kautzner J, Sack S, Husser D, Piorkowski C, Sogaard P; IN-TIME study group. randomised controlled trial.

Hinman RS, McCrory P, Pirotta M, Relf I, Forbes A, Crossley KM, Williamson E, Kyriakides M, Novy K,

Metcalf BR, Harris A, Reddy P, Conaghan PG, Bennell KL.

Acupuncture for chronic knee pain: a randomized clinical trial. Lancet. 2014

Hodi FS, Lee S, McDermott DF, Rao UN, Butterfield LH, Tarhini AA, Leming P, Puzanov I, Shin D,

Kirkwood JM.

Ipilimumab plus sargramostim vs ipilimumab alone for treatment of metastatic melanoma: a

randomized clinical trial.JAMA. 2014

Holst LB, Haase N, Wetterslev J, Wernerman J, Guttormsen AB, Karlsson S, Johansson PI, Aneman

A, Vang ML, Winding R, Nebrich L, Nibro HL, Rasmussen BS, Lauridsen JR, Nielsen JS, Oldner A, Pettilä V, Cronhjort MB, Andersen LH, Pedersen

UG, Reiter N, Wiis J, et al.

Lower versus higher hemoglobin threshold for transfusion in septic shock. JAMA. 2014

HPS2-THRIVE Collaborative Group, Landray MJ, Haynes R, Hopewell JC, Parish S, Aung T, Tomson

J, Wallendszus K, Craig M, Jiang L, Collins R, Armitage J.

Effects of extended-release niacin with laropiprant in high-risk patients. N Engl J Med. 2014

Huang H, Li X, Zhu J, Ye S, Zhang H, Wang W, Wu X, Peng J, Xu B, Lin Y, Cao Y, Li H, Lin S, Liu Q, Lin T.

Entecavir vs lamivudine for prevention of hepatitis B virus reactivation among patients with

untreated diffuse large B-cell lymphoma receiving R-CHOP chemotherapy: a randomized clinical trial.

N Engl J Med. 2014

Huffman JC, Mastromauro CA, Beach SR, Celano CM, DuBois CM, Healy BC, Suarez L, Rollman BL,

Januzzi JL.

Collaborative care for depression and anxiety disorders in patients with recent cardiac events:

the Management of Sadness and Anxiety in Cardiology (MOSAIC) randomized clinical trial.

JAMA. 2014

Hunt K, Wyke S, Gray CM, Anderson AS, Brady A, Bunn C, Donnan PT, Fenwick E, Grieve E, Leishman

J, Miller E, Mutrie N, Rauchhaus P, White A, Treweek S.

A gender-sensitised weight loss and healthy living programme for overweight and obese men

delivered by Scottish Premier League football clubs (FFIT): a pragmatic randomised controlled

trial.

JAMA Intern Med. 2014

Idiopathic Pulmonary Fibrosis Clinical Research Network, Martinez FJ, de Andrade JA, Anstrom KJ,

King TE Jr, Raghu G.

Randomized trial of acetylcysteine in idiopathic pulmonary fibrosis. Lancet. 2014

Iijima K, Sako M, Nozu K, Mori R, Tuchida N, Kamei K, Miura K, Aya K, Nakanishi K, Ohtomo Y,

Takahashi S, Tanaka R, Kaito H, Nakamura H, Ishikura K, Ito S, Ohashi Y; Rituximab for

Childhood-onset Refractory Nephrotic Syndrome (RCRNS) Study Group.

Rituximab for childhood-onset, complicated, frequently relapsing nephrotic syndrome or steroid-dependent nephrotic syndrome: a

multicentre, double-blind, randomised, placebo-controlled trial.

N Engl J Med. 2014

Ikeda Y, Shimada K, Teramoto T, Uchiyama S, Yamazaki T, Oikawa S, Sugawara M, Ando K,

Murata M, Yokoyama K, Ishizuka N.

Low-dose aspirin for primary prevention of cardiovascular events in Japanese patients 60

years or older with atherosclerotic risk factors: a randomized clinical trial.

Lancet. 2014

Ikramuddin S, Blackstone RP, Brancatisano A, Toouli J, Shah SN, Wolfe BM, Fujioka K, Maher JW,

Swain J, Que FG, Morton JM, Leslie DB, Brancatisano R, Kow L, O'Rourke RW, Deveney C,

Takata M, Miller CJ, Knudson MB, Tweden KS, Shikora SA, Sarr MG, et al.

Effect of reversible intermittent intra-abdominal vagal nerve blockade on morbid obesity: the

ReCharge randomized clinical trial.JAMA. 2014

Imazio M, Belli R, Brucato A, Cemin R, Ferrua S, Beqaraj F, Demarie D, Ferro S, Forno D, Maestroni S, Cumetti D, Varbella F, Trinchero R, Spodick DH,

Adler Y.

Efficacy and safety of colchicine for treatment of multiple recurrences of pericarditis (CORP-2): a multicentre, double-blind, placebo-controlled,

randomised trial.

JAMA. 2014

Imazio M, Brucato A, Ferrazzi P, Pullara A, Adler Y, Barosi A, Caforio AL, Cemin R, Chirillo F, Comoglio

C, Cugola D, Cumetti D, Dyrda O, Ferrua S, Finkelstein Y, Flocco R, Gandino A, Hoit B,

Innocente F, Maestroni S, Musumeci F, Oh J, et al.

Colchicine for prevention of postpericardiotomy syndrome and postoperative atrial fibrillation: the

COPPS-2 randomized clinical trial.Lancet. 2014

IMPROVE Trial Investigators, Powell JT, Sweeting MJ, Thompson MM, Ashleigh R, Bell R, Gomes M, Greenhalgh RM, Grieve R, Heatley F, Hinchliffe RJ,

Thompson SG, Ulug P.

Endovascular or open repair strategy for ruptured abdominal aortic aneurysm: 30 day outcomes

from IMPROVE randomised trial.JAMA. 2014

Iranmanesh P, Frossard JL, Mugnier-Konrad B, Morel P, Majno P, Nguyen-Tang T, Berney T,

Initial cholecystectomy vs sequential common duct endoscopic assessment and subsequent BMJ. 2014

Mentha G, Toso C. cholecystectomy for suspected gallstone migration: a randomized clinical trial.

Jorgensen T, Jacobsen RK, Toft U, Aadahl M, Glumer C, Pisinger C.

Effect of screening and lifestyle counselling on incidence of ischaemic heart disease in general

population: Inter99 randomised trial.JAMA. 2014

Juttler E, Unterberg A, Woitzik J, Bosel J, Amiri H, Sakowitz OW, Gondan M, Schiller P, Limprecht R,

Luntz S, Schneider H, Pinzer T, Hobohm C, Meixensberger J, Hacke W; DESTINY II

Investigators.

Hemicraniectomy in older patients with extensive middle-cerebral-artery stroke. BMJ. 2014

Jacobson IM, Dore GJ, Foster GR, Fried MW, Radu M, Rafalsky VV, Moroz L, Craxi A, Peeters M, Lenz

O, Ouwerkerk-Mahadevan S, De La Rosa G, Kalmeijer R, Scott J, Sinha R, Beumont-Mauviel M.

Simeprevir with pegylated interferon alfa 2a plus ribavirin in treatment-naive patients with chronic hepatitis C virus genotype 1 infection (QUEST-1): a

phase 3, randomised, double-blind, placebo-controlled trial.

N Engl J Med. 2014

Jindani A, Harrison TS, Nunn AJ, Phillips PP, Churchyard GJ, Charalambous S, Hatherill M,

Geldenhuys H, McIlleron HM, Zvada SP, Mungofa S, Shah NA, Zizhou S, Magweta L, Shepherd J,

Nyirenda S, van Dijk JH, Clouting HE, Coleman D, Bateson AL, McHugh TD, Butcher PD, et al.

High-dose rifapentine with moxifloxacin for pulmonary tuberculosis. Lancet. 2014

Joffe H, Guthrie KA, LaCroix AZ, Reed SD, Ensrud KE, Manson JE, Newton KM, Freeman EW,

Anderson GL, Larson JC, Hunt J, Shifren J, Rexrode KM, Caan B, Sternfeld B, Carpenter JS, Cohen L.

Low-dose estradiol and the serotonin-norepinephrine reuptake inhibitor venlafaxine for vasomotor symptoms: a randomized clinical trial.

N Engl J Med. 2014

John J, Giri S, Karthikeyan AS, Iturriza-Gomara M, Muliyil J, Abraham A, Grassly NC, Kang G.

Effect of a single inactivated poliovirus vaccine dose on intestinal immunity against poliovirus in children previously given oral vaccine: an open-

label, randomised controlled trial.

JAMA Intern Med. 2014

Kahn SR, Shapiro S, Wells PS, Rodger MA, Kovacs MJ, Anderson DR, Tagalakis V, Houweling AH,

Ducruet T, Holcroft C, Johri M, Solymoss S, Miron

Compression stockings to prevent post-thrombotic syndrome: a randomised placebo-

controlled trial.Lancet. 2014

MJ, Yeo E, Smith R, Schulman S, Kassis J, Kearon C, Chagnon I, Wong T, Demers C, Hanmiah R, et al.

Keyserling TC, Sheridan SL, Draeger LB, Finkelstein EA, Gizlice Z, Kruger E, Johnston LF, Sloane PD,

Samuel-Hodge C, Evenson KR, Gross MD, Donahue KE, Pignone MP, Vu MB, Steinbacher EA, Weiner

BJ, Bangdiwala SI, Ammerman AS.

A comparison of live counseling with a web-based lifestyle and medication intervention to reduce

coronary heart disease risk: a randomized clinical trial.

Lancet. 2014

Kim F, Nichol G, Maynard C, Hallstrom A, Kudenchuk PJ, Rea T, Copass MK, Carlbom D,

Deem S, Longstreth WT Jr, Olsufka M, Cobb LA.

Effect of prehospital induction of mild hypothermia on survival and neurological status among adults with cardiac arrest: a randomized

clinical trial.

JAMA Intern Med. 2014

King TE Jr, Bradford WZ, Castro-Bernardini S, Fagan EA, Glaspole I, Glassberg MK, Gorina E,

Hopkins PM, Kardatzke D, Lancaster L, Lederer DJ, Nathan SD, Pereira CA, Sahn SA, Sussman R, Swigris JJ, Noble PW; ASCEND Study Group.

A phase 3 trial of pirfenidone in patients with idiopathic pulmonary fibrosis. JAMA. 2014

Knip M, Ackerblom HK, Becker D, Dosch HM, Dupre J, Fraser W, Howard N, Ilonen J, Krischer JP, Kordonouri O, Lawson ML, Palmer JP, Savilahti E,

Vaarala O, Virtanen SM; TRIGR Study Group.

Hydrolyzed infant formula and early β-cell autoimmunity: a randomized clinical trial. N Engl J Med. 2014

Knoll GA, Humar A, Fergusson D, Johnston O, House AA, Kim SJ, Ramsay T, Chasse M, Pang X,

Zaltzman J, Cockfield S, Cantarovich M, Karpinski M, Lebel L, Gill JS.

Levofloxacin for BK virus prophylaxis following kidney transplantation: a randomized clinical trial. JAMA. 2014

Koegelenberg CF, Noor F, Bateman ED, van Zyl-Smit RN, Bruning A, O'Brien JA, Smith C, Abdool-

Gaffar MS, Emanuel S, Esterhuizen TM, Irusen EM.

Efficacy of varenicline combined with nicotine replacement therapy vs varenicline alone for smoking cessation: a randomized clinical trial.

JAMA. 2014

Kosiborod M, Rasmussen HS, Lavin P, Qunibi WY, Spinowitz B, Packham D, Roger SD, Yang A, Lerma

E, Singh B.

Effect of sodium zirconium cyclosilicate on potassium lowering for 28 days among

outpatients with hyperkalemia: the HARMONIZE randomized clinical trial.

JAMA. 2014

Kowdley KV, Gordon SC, Reddy KR, Rossaro L, Bernstein DE, Lawitz E, Shiffman ML, Schiff E,

Ghalib R, Ryan M, Rustgi V, Chojkier M, Herring R, Di Bisceglie AM, Pockros PJ, Subramanian GM, An

D, Svarovskaia E, Hyland RH, Pang PS, Symonds WT, McHutchison JG, et al.

Ledipasvir and sofosbuvir for 8 or 12 weeks for chronic HCV without cirrhosis. JAMA. 2014

Kowdley KV, Lawitz E, Poordad F, Cohen DE, Nelson DR, Zeuzem S, Everson GT, Kwo P, Foster

GR, Sulkowski MS, Xie W, Pilot-Matias T, Liossis G, Larsen L, Khatri A, Podsadecki T, Bernstein B.

Phase 2b trial of interferon-free therapy for hepatitis C virus genotype 1. N Engl J Med. 2014

Kroenke K, Krebs EE, Wu J, Yu Z, Chumbler NR, Bair MJ.

Telecare collaborative management of chronic pain in primary care: a randomized clinical trial. N Engl J Med. 2014

Kypri K, Vater T, Bowe SJ, Saunders JB, Cunningham JA, Horton NJ, McCambridge J.

Web-based alcohol screening and brief intervention for university students: a randomized

trial.JAMA. 2014

Lacro RV, Dietz HC, Sleeper LA, Yetman AT, Bradley TJ, Colan SD, Pearson GD, Selamet Tierney ES, Levine JC, Atz AM, Benson DW, Braverman AC, Chen S, De Backer J, Gelb BD, Grossfeld PD, Klein

GL, Lai WW, Liou A, Loeys BL, Markham LW, Olson AK, et al.

Atenolol versus losartan in children and young adults with Marfan's syndrome. JAMA. 2014

Laing BY, Mangione CM, Tseng CH, Leng M, Vaisberg E, Mahida M, Bholat M, Glazier E,

Morisky DE, Bell DS.

Effectiveness of a smartphone application for weight loss compared with usual care in

overweight primary care patients: a randomized, controlled trial.

N Engl J Med. 2014

Langley RG, Elewski BE, Lebwohl M, Reich K, Griffiths CE, Papp K, Puig L, Nakagawa H, Spelman L, Sigurgeirsson B, Rivas E, Tsai TF, Wasel N, Tyring S, Salko T, Hampele I, Notter M, Karpov A, Helou S, Papavassilis C; ERASURE Study Group; FIXTURE

Study Group.

Secukinumab in plaque psoriasis--results of two phase 3 trials. Ann Intern Med. 2014

Larkin J, Ascierto PA, Dreno B, Atkinson V, Liszkay G, Maio M, Mandala M, Demidov L, Stroyakovskiy

D, Thomas L, de la Cruz-Merino L, Dutriaux C,

Combined vemurafenib and cobimetinib in BRAF-mutated melanoma. N Engl J Med. 2014

Garbe C, Sovak MA, Chang I, Choong N, Hack SP, McArthur GA, Ribas A.

Latham NK, Harris BA, Bean JF, Heeren T, Goodyear C, Zawacki S, Heislein DM, Mustafa J, Pardasaney P, Giorgetti M, Holt N, Goehring L,

Jette AM.

Effect of a home-based exercise program on functional recovery following rehabilitation after

hip fracture: a randomized clinical trial.N Engl J Med. 2014

Lawitz E, Poordad FF, Pang PS, Hyland RH, Ding X, Mo H, Symonds WT, McHutchison JG, Membreno

FE.

Sofosbuvir and ledipasvir fixed-dose combination with and without ribavirin in treatment-naive and

previously treated patients with genotype 1 hepatitis C virus infection (LONESTAR): an open-

label, randomised, phase 2 trial.

JAMA. 2014

Lawitz E, Sulkowski MS, Ghalib R, Rodriguez-Torres M, Younossi ZM, Corregidor A, DeJesus E,

Pearlman B, Rabinovitz M, Gitlin N, Lim JK, Pockros PJ, Scott JD, Fevery B, Lambrecht T,

Ouwerkerk-Mahadevan S, Callewaert K, Symonds WT, Picchio G, Lindsay KL, Beumont M, Jacobson

IM.

Simeprevir plus sofosbuvir, with or without ribavirin, to treat chronic infection with hepatitis

C virus genotype 1 in non-responders to pegylated interferon and ribavirin and treatment-naive

patients: the COSMOS randomised study.

Lancet. 2014

Lee EB, Fleischmann R, Hall S, Wilkinson B, Bradley JD, Gruben D, Koncz T, Krishnaswami S,

Wallenstein GV, Zang C, Zwillich SH, van Vollenhoven RF; ORAL Start Investigators.

Tofacitinib versus methotrexate in rheumatoid arthritis. Lancet. 2014

Legro RS, Brzyski RG, Diamond MP, Coutifaris C, Schlaff WD, Casson P, Christman GM, Huang H, Yan Q, Alvero R, Haisenleder DJ, Barnhart KT,

Bates GW, Usadi R, Lucidi S, Baker V, Trussell JC, Krawetz SA, Snyder P, Ohl D, Santoro N, Eisenberg

E, et al.

Letrozole versus clomiphene for infertility in the polycystic ovary syndrome. N Engl J Med. 2014

Lennox JL, Landovitz RJ, Ribaudo HJ, Ofotokun I, Na LH, Godfrey C, Kuritzkes DR, Sagar M, Brown

TT, Cohn SE, McComsey GA, Aweeka F, Fichtenbaum CJ, Presti RM, Koletar SL, Haas DW,

Efficacy and tolerability of 3 nonnucleoside reverse transcriptase inhibitor-sparing

antiretroviral regimens for treatment-naive volunteers infected with HIV-1: a randomized,

N Engl J Med. 2014

Patterson KB, Benson CA, Baugh BP, Leavitt RY, Rooney JF, Seekins D, et al. controlled equivalence trial.

Lexis CP, van der Horst IC, Lipsic E, Wieringa WG, de Boer RA, van den Heuvel AF, van der Werf HW,

Schurer RA, Pundziute G, Tan ES, Nieuwland W, Willemsen HM, Dorhout B, Molmans BH, van der Horst-Schrivers AN, Wolffenbuttel BH, ter Horst

GJ, van Rossum AC, Tijssen JG, Hillege HL, de Smet BJ, van der Harst P, et al.

Effect of metformin on left ventricular function after acute myocardial infarction in patients

without diabetes: the GIPS-III randomized clinical trial.

Ann Intern Med. 2014

Li R, Liu L, Mo Z, Wang X, Xia J, Liang Z, Zhang Y, Li Y, Mao Q, Wang J, Jiang L, Dong C, Che Y, Huang T, Jiang Z, Xie Z, Wang L, Liao Y, Liang Y, Nong Y, Liu

J, Zhao H, et al.

An inactivated enterovirus 71 vaccine in healthy children. JAMA. 2014

Liebschutz JM, Crooks D, Herman D, Anderson B, Tsui J, Meshesha LZ, Dossabhoy S, Stein M.

Buprenorphine treatment for hospitalized, opioid-dependent patients: a randomized clinical trial. JAMA Intern Med. 2014

Lincoff AM, Tardif JC, Schwartz GG, Nicholls SJ, Ryden L, Neal B, Malmberg K, Wedel H, Buse JB, Henry RR, Weichert A, Cannata R, Svensson A, Volz D, Grobbee DE; AleCardio Investigators.

Effect of aleglitazar on cardiovascular outcomes after acute coronary syndrome in patients with

type 2 diabetes mellitus: the AleCardio randomized clinical trial.

JAMA. 2014

Little P, Moore M, Kelly J, Williamson I, Leydon G, McDermott L, Mullee M, Stuart B; PIPS

Investigators.

Delayed antibiotic prescribing strategies for respiratory tract infections in primary care:

pragmatic, factorial, randomised controlled trial.BMJ. 2014

Llanos-Cuentas A, Lacerda MV, Rueangweerayut R, Krudsood S, Gupta SK, Kochar SK, Arthur P,

Chuenchom N, Mohrle JJ, Duparc S, Ugwuegbulam C, Kleim JP, Carter N, Green JA, Kellam L.

Tafenoquine plus chloroquine for the treatment and relapse prevention of Plasmodium vivax

malaria (DETECTIVE): a multicentre, double-blind, randomised, phase 2b dose-selection study.

Lancet. 2014

Long GV, Stroyakovskiy D, Gogas H, Levchenko E, de Braud F, Larkin J, Garbe C, Jouary T, Hauschild

A, Grob JJ, Chiarion Sileni V, Lebbe C, Mandala M, Millward M, Arance A, Bondarenko I, Haanen JB,

Hansson J, Utikal J, Ferraresi V, Kovalenko N, Mohr P, et al.

Combined BRAF and MEK inhibition versus BRAF inhibition alone in melanoma. N Engl J Med. 2014

Loupakis F, Cremolini C, Masi G, Lonardi S, Zagonel V, Salvatore L, Cortesi E, Tomasello G,

Initial therapy with FOLFOXIRI and bevacizumab for metastatic colorectal cancer. N Engl J Med. 2014

Ronzoni M, Spadi R, Zaniboni A, Tonini G, Buonadonna A, Amoroso D, Chiara S, Carlomagno

C, Boni C, Allegrini G, Boni L, Falcone A.Macrae D, Grieve R, Allen E, Sadique Z, Morris K, Pappachan J, Parslow R, Tasker RC, Elbourne D;

CHiP Investigators.

A randomized trial of hyperglycemic control in pediatric intensive care. N Engl J Med. 2014

Madhi SA, Cutland CL, Kuwanda L, Weinberg A, Hugo A, Jones S, Adrian PV, van Niekerk N,

Treurnicht F, Ortiz JR, Venter M, Violari A, Neuzil KM, Simoes EA, Klugman KP, Nunes MC; Maternal

Flu Trial (Matflu) Team.

Influenza vaccination of pregnant women and protection of their infants. N Engl J Med. 2014

Maeng M, Tilsted HH, Jensen LO, Krusell LR, Kaltoft A, Kelbaek H, Villadsen AB, Ravkilde J,

Hansen KN, Christiansen EH, Aaroe J, Jensen JS, Kristensen SD, Botker HE, Thuesen L, Madsen M,

Thayssen P, Sorensen HT, Lassen JF.

Differential clinical outcomes after 1 year versus 5 years in a randomised comparison of zotarolimus-eluting and sirolimus-eluting coronary stents (the

SORT OUT III study): a multicentre, open-label, randomised superiority trial.

Lancet. 2014

Magnussen H, Disse B, Rodriguez-Roisin R, Kirsten A, Watz H, Tetzlaff K, Towse L, Finnigan H, Dahl R, Decramer M, Chanez P, Wouters EF, Calverley PM;

WISDOM Investigators.

Withdrawal of inhaled glucocorticoids and exacerbations of COPD. N Engl J Med. 2014

Manns M, Marcellin P, Poordad F, de Araujo ES, Buti M, Horsmans Y, Janczewska E, Villamil F, Scott

J, Peeters M, Lenz O, Ouwerkerk-Mahadevan S, De La Rosa G, Kalmeijer R, Sinha R, Beumont-

Mauviel M.

Simeprevir with pegylated interferon alfa 2a or 2b plus ribavirin in treatment-naive patients with chronic hepatitis C virus genotype 1 infection

(QUEST-2): a randomised, double-blind, placebo-controlled phase 3 trial.

Lancet. 2014

Manns M, Pol S, Jacobson IM, Marcellin P, Gordon SC, Peng CY, Chang TT, Everson GT, Heo J, Gerken

G, Yoffe B, Towner WJ, Bourliere M, Metivier S, Chu CJ, Sievert W, Bronowicki JP, Thabut D, Lee YJ,

Kao JH, McPhee F, Kopit J, et al.

All-oral daclatasvir plus asunaprevir for hepatitis C virus genotype 1b: a multinational, phase 3,

multicohort study.Lancet. 2014

Mason BJ, Quello S, Goodell V, Shadan F, Kyle M, Begovic A.

Gabapentin treatment for alcohol dependence: a randomized clinical trial. JAMA Intern Med. 2014

Mauri L, Kereiakes DJ, Yeh RW, Driscoll-Shempp P, Cutlip DE, Steg PG, Normand SL, Braunwald E,

Twelve or 30 months of dual antiplatelet therapy after drug-eluting stents. N Engl J Med. 2014

Wiviott SD, Cohen DJ, Holmes DR Jr, Krucoff MW, Hermiller J, Dauerman HL, Simon DI, Kandzari DE, Garratt KN, Lee DP, Pow TK, Ver Lee P, Rinaldi MJ,

Massaro JM; et al.Mayosi BM, Ntsekhe M, Bosch J, Pandie S, Jung H, Gumedze F, Pogue J, Thabane L, Smieja M, Francis V, Joldersma L, Thomas KM, Thomas B, Awotedu AA, Magula NP, Naidoo DP, Damasceno A, Chitsa Banda A, Brown B, Manga P, Kirenga B, Mondo C,

et al.

Prednisolone and Mycobacterium indicus pranii in tuberculous pericarditis. N Engl J Med. 2014

McAllister L, Anderson J, Werth K, Cho I, Copeland K, Le Cam Bouveret N, Plant D, Mendelman PM,

Cobb DK.

Needle-free jet injection for administration of influenza vaccine: a randomised non-inferiority

trial.Lancet. 2014

McAuley DF, Laffey JG, O'Kane CM, Perkins GD, Mullan B, Trinder TJ, Johnston P, Hopkins PA, Johnston AJ, McDowell C, McNally C; HARP-2 Investigators; Irish Critical Care Trials Group.

Simvastatin in the acute respiratory distress syndrome. N Engl J Med. 2014

McClung MR, Grauer A, Boonen S, Bolognese MA, Brown JP, Diez-Perez A, Langdahl BL, Reginster JY, Zanchetta JR, Wasserman SM, Katz L, Maddox J,

Yang YC, Libanati C, Bone HG.

Romosozumab in postmenopausal women with low bone mineral density. N Engl J Med. 2014

McEvoy CT, Schilling D, Clay N, Jackson K, Go MD, Spitale P, Bunten C, Leiva M, Gonzales D, Hollister-

Smith J, Durand M, Frei B, Buist AS, Peters D, Morris CD, Spindel ER.

Vitamin C supplementation for pregnant smoking women and pulmonary function in their newborn

infants: a randomized clinical trial.JAMA. 2014

McEvoy JP, Byerly M, Hamer RM, Dominik R, Swartz MS, Rosenheck RA, Ray N, Lamberti JS,

Buckley PF, Wilkins TM, Stroup TS.

Effectiveness of paliperidone palmitate vs haloperidol decanoate for maintenance treatment

of schizophrenia: a randomized clinical trial.JAMA. 2014

McManus RJ, Mant J, Haque MS, Bray EP, Bryan S, Greenfield SM, Jones MI, Jowett S, Little P,

Penaloza C, Schwartz C, Shackleford H, Shovelton C, Varghese J, Williams B, Hobbs FD, Gooding T,

Effect of self-monitoring and medication self-titration on systolic blood pressure in hypertensive patients at high risk of

cardiovascular disease: the TASMIN-SR

JAMA. 2014

Morrey I, Fisher C, Buckley D. randomized clinical trial.McMurray JJ, Packer M, Desai AS, Gong J,

Lefkowitz MP, Rizkala AR, Rouleau JL, Shi VC, Solomon SD, Swedberg K, Zile MR; PARADIGM-HF

Investigators and Committees.

Angiotensin-neprilysin inhibition versus enalapril in heart failure. N Engl J Med. 2014

Mease PJ, Genovese MC, Greenwald MW, Ritchlin CT, Beaulieu AD, Deodhar A, Newmark R, Feng J,

Erondu N, Nirula A.

Brodalumab, an anti-IL17RA monoclonal antibody, in psoriatic arthritis. N Engl J Med. 2014

Merle CS, Fielding K, Sow OB, Gninafon M, Lo MB, Mthiyane T, Odhiambo J, Amukoye E, Bah B, Kassa

F, N'Diaye A, Rustomjee R, de Jong BC, Horton J, Perronne C, Sismanidis C, Lapujade O, Olliaro PL,

Lienhardt C; OFLOTUB/Gatifloxacin for Tuberculosis Project.

A four-month gatifloxacin-containing regimen for treating tuberculosis. N Engl J Med. 2014

Meyer G, Vicaut E, Danays T, Agnelli G, Becattini C, Beyer-Westendorf J, Bluhmki E, Bouvaist H,

Brenner B, Couturaud F, Dellas C, Empen K, Franca A, Galie N, Geibel A, Goldhaber SZ, Jimenez D,

Kozak M, Kupatt C, Kucher N, Lang IM, Lankeit M, et al.

Fibrinolysis for patients with intermediate-risk pulmonary embolism. N Engl J Med. 2014

Michaleff ZA, Maher CG, Lin CW, Rebbeck T, Jull G, Latimer J, Connelly L, Sterling M.

Comprehensive physiotherapy exercise programme or advice for chronic whiplash

(PROMISE): a pragmatic randomised controlled trial.

Lancet. 2014

Mohr JP, Parides MK, Stapf C, Moquete E, Moy CS, Overbey JR, Al-Shahi Salman R, Vicaut E, Young

WL, Houdart E, Cordonnier C, Stefani MA, Hartmann A, von Kummer R, Biondi A, Berkefeld J,

Klijn CJ, Harkness K, Libman R, Barreau X, Moskowitz AJ; international ARUBA investigators.

Medical management with or without interventional therapy for unruptured brain

arteriovenous malformations (ARUBA): a multicentre, non-blinded, randomised trial.

Lancet. 2014

Mol F, van Mello NM, Strandell A, Strandell K, Salpingotomy versus salpingectomy in women Lancet. 2014

Jurkovic D, Ross J, Barnhart KT, Yalcinkaya TM, Verhoeve HR, Graziosi GC, Koks CA, Klinte I,

Hogstrom L, Janssen IC, Kragt H, Hoek A, Trimbos-Kemper TC, Broekmans FJ, Willemsen WN, Ankum

WM, Mol BW, van Wely M, et al.

with tubal pregnancy (ESEP study): an open-label, multicentre, randomised controlled trial.

Molina I, Gomez i Prat J, Salvador F, Trevino B, Sulleiro E, Serre N, Pou D, Roure S, Cabezos J,

Valerio L, Blanco-Grau A, Sanchez-Montalva A, Vidal X, Pahissa A.

Randomized trial of posaconazole and benznidazole for chronic Chagas' disease. N Engl J Med. 2014

Montalescot G, van 't Hof AW, Lapostolle F, Silvain J, Lassen JF, Bolognese L, Cantor WJ, Cequier A, Chettibi M, Goodman SG, Hammett CJ, Huber K,

Janzon M, Merkely B, Storey RF, Zeymer U, Stibbe O, Ecollan P, Heutz WM, Swahn E, Collet JP,

Willems FF, et al.

Prehospital ticagrelor in ST-segment elevation myocardial infarction. N Engl J Med. 2014

Morillo CA, Verma A, Connolly SJ, Kuck KH, Nair GM, Champagne J, Sterns LD, Beresh H, Healey JS,

Natale A; RAAFT-2 Investigators.

Radiofrequency ablation vs antiarrhythmic drugs as first-line treatment of paroxysmal atrial fibrillation (RAAFT-2): a randomized trial.

JAMA. 2014

Morrison AP, Turkington D, Pyle M, Spencer H, Brabban A, Dunn G, Christodoulides T, Dudley R, Chapman N, Callcott P, Grace T, Lumley V, Drage L, Tully S, Irving K, Cummings A, Byrne R, Davies

LM, Hutton P.

Cognitive therapy for people with schizophrenia spectrum disorders not taking antipsychotic

drugs: a single-blind randomised controlled trial.Lancet. 2014

Morton DL, Thompson JF, Cochran AJ, Mozzillo N, Nieweg OE, Roses DF, Hoekstra HJ, Karakousis CP, Puleo CA, Coventry BJ, Kashani-Sabet M, Smithers BM, Paul E, Kraybill WG, McKinnon JG, Wang HJ,

Elashoff R, Faries MB; MSLT Group.

Final trial report of sentinel-node biopsy versus nodal observation in melanoma. N Engl J Med. 2014

Mosquera RA, Avritscher EB, Samuels CL, Harris TS, Pedroza C, Evans P, Navarro F, Wootton SH,

Pacheco S, Clifton G, Moody S, Franzini L, Zupancic J, Tyson JE.

Effect of an enhanced medical home on serious illness and cost of care among high-risk children with chronic illness: a randomized clinical trial.

JAMA. 2014

Moulton CA, Gu CS, Law CH, Tandan VR, Hart R, Effect of PET before liver resection on surgical JAMA. 2014

Quan D, Fairfull Smith RJ, Jalink DW, Husien M, Serrano PE, Hendler AL, Haider MA, Ruo L,

Gulenchyn KY, Finch T, Julian JA, Levine MN, Gallinger S.

management for colorectal adenocarcinoma metastases: a randomized clinical trial.

Muhlestein JB, Lappe DL, Lima JA, Rosen BD, May HT, Knight S, Bluemke DA, Towner SR, Le V, Bair

TL, Vavere AL, Anderson JL.

Effect of screening for coronary artery disease using CT angiography on mortality and cardiac events in high-risk patients with diabetes: the

FACTOR-64 randomized clinical trial.

JAMA. 2014

Mulligan MJ, Bernstein DI, Winokur P, Rupp R, Anderson E, Rouphael N, Dickey M, Stapleton JT,

Edupuganti S, Spearman P, Ince D, Noah DL, Hill H, Bellamy AR; DMID 13-0032 H7N9 Vaccine Study

Group.

Serological responses to an avian influenza A/H7N9 vaccine mixed at the point-of-use with

MF59 adjuvant: a randomized clinical trial.JAMA. 2014

Munoz FM, Bond NH, Maccato M, Pinell P, Hammill HA, Swamy GK, Walter EB, Jackson LA, Englund JA, Edwards MS, Healy CM, Petrie CR,

Ferreira J, Goll JB, Baker CJ.

Safety and immunogenicity of tetanus diphtheria and acellular pertussis (Tdap) immunization during pregnancy in mothers and infants: a

randomized clinical trial.

JAMA. 2014

Myles PS, Leslie K, Chan MT, Forbes A, Peyton PJ, Paech MJ, Beattie WS, Sessler DI, Devereaux PJ,

Silbert B, Schricker T, Wallace S; ANZCA Trials Group for the ENIGMA-II investigators.

The safety of addition of nitrous oxide to general anaesthesia in at-risk patients having major non-

cardiac surgery (ENIGMA-II): a randomised, single-blind trial.

Lancet. 2014

National Heart, Lung, and Blood Institute ARDS Clinical Trials Network, Truwit JD, Bernard GR, Steingrub J, Matthay MA, Liu KD, Albertson TE,

Brower RG, Shanholtz C, Rock P, Douglas IS, deBoisblanc BP, Hough CL, Hite RD, Thompson BT.

Rosuvastatin for sepsis-associated acute respiratory distress syndrome. N Engl J Med. 2014

Newby LK, Marber MS, Melloni C, Sarov-Blat L, Aberle LH, Aylward PE, Cai G, de Winter RJ, Hamm

CW, Heitner JF, Kim R, Lerman A, Patel MR, Tanguay JF, Lepore JJ, Al-Khalidi HR, Sprecher DL,

Granger CB; SOLSTICE Investigators.

Losmapimod, a novel p38 mitogen-activated protein kinase inhibitor, in non-ST-segment

elevation myocardial infarction: a randomised phase 2 trial.

Lancet. 2014

Nicholls SJ, Kastelein JJ, Schwartz GG, Bash D, Rosenson RS, Cavender MA, Brennan DM, Koenig

W, Jukema JW, Nambi V, Wright RS, Menon V,

Varespladib and cardiovascular events in patients with an acute coronary syndrome: the VISTA-16

randomized clinical trial.JAMA. 2014

Lincoff AM, Nissen SE; VISTA-16 Investigators.NORDIC Idiopathic Intracranial Hypertension

Study Group Writing Committee, Wall M, McDermott MP, Kieburtz KD, Corbett JJ, Feldon SE, Friedman DI, Katz DM, Keltner JL, Schron EB,

Kupersmith MJ.

Effect of acetazolamide on visual function in patients with idiopathic intracranial hypertension

and mild visual loss: the idiopathic intracranial hypertension treatment trial.

JAMA. 2014

O'Donoghue ML, Braunwald E, White HD, Lukas MA, Tarka E, Steg PG, Hochman JS, Bode C, Maggioni AP, Im K, Shannon JB, Davies RY,

Murphy SA, Crugnale SE, Wiviott SD, Bonaca MP, Watson DF, Weaver WD, Serruys PW, Cannon CP;

SOLID-TIMI 52 Investigators, Steen DL.

Effect of darapladib on major coronary events after an acute coronary syndrome: the SOLID-TIMI

52 randomized clinical trial.JAMA. 2014

Olsen MF, Abdissa A, Kaestel P, Tesfaye M, Yilma D, Girma T, Wells JC, Ritz C, Molgaard C,

Michaelsen KF, Zerfu D, Brage S, Andersen AB, Friis H.

Effects of nutritional supplementation for HIV patients starting antiretroviral treatment:

randomised controlled trial in Ethiopia.BMJ. 2014

Ortega HG, Liu MC, Pavord ID, Brusselle GG, FitzGerald JM, Chetta A, Humbert M, Katz LE,

Keene ON, Yancey SW, Chanez P; MENSA Investigators.

Mepolizumab treatment in patients with severe eosinophilic asthma. N Engl J Med. 2014

Packham DK, Rasmussen HS, Lavin PT, El-Shahawy MA, Roger SD, Block G, Qunibi W, Pergola P, Singh

B.Sodium zirconium cyclosilicate in hyperkalemia. N Engl J Med. 2015

Pagani O, Regan MM, Walley BA, Fleming GF, Colleoni M, Lang I, Gomez HL, Tondini C, Burstein HJ, Perez EA, Ciruelos E, Stearns V, Bonnefoi HR,

Martino S, Geyer CE Jr, Pinotti G, Puglisi F, Crivellari D, Ruhstaller T, Winer EP, Rabaglio-

Poretti M, Maibach R, et al.

Adjuvant exemestane with ovarian suppression in premenopausal breast cancer. N Engl J Med. 2014

Pahor M, Guralnik JM, Ambrosius WT, Blair S, Bonds DE, Church TS, Espeland MA, Fielding RA,

Gill TM, Groessl EJ, King AC, Kritchevsky SB, Manini TM, McDermott MM, Miller ME, Newman AB, Rejeski WJ, Sink KM, Williamson JD; LIFE study

Effect of structured physical activity on prevention of major mobility disability in older adults: the

LIFE study randomized clinical trial.

JAMA. 2014

investigators.Palumbo A, Cavallo F, Gay F, Di Raimondo F, Ben

Yehuda D, Petrucci MT, Pezzatti S, Caravita T, Cerrato C, Ribakovsky E, Genuardi M, Cafro A,

Marcatti M, Catalano L, Offidani M, Carella AM, Zamagni E, Patriarca F, Musto P, Evangelista A,

Ciccone G, Omedé P, et al.

Autologous transplantation and maintenance therapy in multiple myeloma. N Engl J Med. 2014

Paton NI, Kityo C, Hoppe A, Reid A, Kambugu A, Lugemwa A, van Oosterhout JJ, Kiconco M, Siika

A, Mwebaze R, Abwola M, Abongomera G, Mweemba A, Alima H, Atwongyeire D, Nyirenda R,

Boles J, Thompson J, Tumukunde D, Chidziva E, Mambule I, Arribas JR, et al.

Assessment of second-line antiretroviral regimens for HIV therapy in Africa. N Engl J Med. 2014

PD Med Collaborative Group, Gray R, Ives N, Rick C, Patel S, Gray A, Jenkinson C, McIntosh E,

Wheatley K, Williams A, Clarke CE.

Long-term effectiveness of dopamine agonists and monoamine oxidase B inhibitors compared with

levodopa as initial treatment for Parkinson's disease (PD MED): a large, open-label, pragmatic

randomised trial.

Lancet. 2014

Pearse RM, Harrison DA, MacDonald N, Gillies MA, Blunt M, Ackland G, Grocott MP, Ahern A, Griggs K, Scott R, Hinds C, Rowan K; OPTIMISE

Study Group.

Effect of a perioperative, cardiac output-guided hemodynamic therapy algorithm on outcomes

following major gastrointestinal surgery: a randomized clinical trial and systematic review.

JAMA. 2014

Phoa KN, van Vilsteren FG, Weusten BL, Bisschops R, Schoon EJ, Ragunath K, Fullarton G, Di Pietro M,

Ravi N, Visser M, Offerhaus GJ, Seldenrijk CA, Meijer SL, ten Kate FJ, Tijssen JG, Bergman JJ.

Radiofrequency ablation vs endoscopic surveillance for patients with Barrett esophagus and low-grade dysplasia: a randomized clinical

trial.

JAMA. 2014

Pilgrim T, Heg D, Roffi M, Tuller D, Muller O, Vuilliomenet A, Cook S, Weilenmann D, Kaiser C,

Jamshidi P, Fahrni T, Moschovitis A, Noble S, Eberli FR, Wenaweser P, Juni P, Windecker S.

Ultrathin strut biodegradable polymer sirolimus-eluting stent versus durable polymer everolimus-

eluting stent for percutaneous coronary revascularisation (BIOSCIENCE): a randomised,

single-blind, non-inferiority trial.

Lancet. 2014

Pisansky TM, Pugh SL, Greenberg RE, Pervez N, Reed DR, Rosenthal SA, Mowat RB, Raben A, Buyyounouski MK, Kachnic LA, Bruner DW.

Tadalafil for prevention of erectile dysfunction after radiotherapy for prostate cancer: the Radiation Therapy Oncology Group [0831]

randomized clinical trial.

JAMA. 2014

Pitt B, Pfeffer MA, Assmann SF, Boineau R, Anand IS, Claggett B, Clausell N, Desai AS, Diaz R, Fleg JL, Gordeev I, Harty B, Heitner JF, Kenwood CT, Lewis EF, O'Meara E, Probstfield JL, Shaburishvili T, Shah

SJ, Solomon SD, Sweitzer NK, Yang S, et al.

Spironolactone for heart failure with preserved ejection fraction. N Engl J Med. 2014

Poordad F, Hezode C, Trinh R, Kowdley KV, Zeuzem S, Agarwal K, Shiffman ML, Wedemeyer

H, Berg T, Yoshida EM, Forns X, Lovell SS, Da Silva-Tillmann B, Collins CA, Campbell AL, Podsadecki T,

Bernstein B.

ABT-450/r-ombitasvir and dasabuvir with ribavirin for hepatitis C with cirrhosis. N Engl J Med. 2014

Porsteinsson AP, Drye LT, Pollock BG, Devanand DP, Frangakis C, Ismail Z, Marano C, Meinert CL,

Mintzer JE, Munro CA, Pelton G, Rabins PV, Rosenberg PB, Schneider LS, Shade DM,

Weintraub D, Yesavage J, Lyketsos CG; CitAD Research Group.

Effect of citalopram on agitation in Alzheimer disease: the CitAD randomized clinical trial. JAMA. 2014

ProCESS Investigators, Yealy DM, Kellum JA, Huang DT, Barnato AE, Weissfeld LA, Pike F,

Terndrup T, Wang HE, Hou PC, LoVecchio F, Filbin MR, Shapiro NI, Angus DC.

A randomized trial of protocol-based care for early septic shock. N Engl J Med. 2014

PROVE Network Investigators for the Clinical Trial Network of the European Society of

Anaesthesiology, Hemmes SN, Gama de Abreu M, Pelosi P, Schultz MJ.

High versus low positive end-expiratory pressure during general anaesthesia for open abdominal

surgery (PROVHILO trial): a multicentre randomised controlled trial.

Lancet. 2014

Prymula R, Bergsaker MR, Esposito S, Gothefors L, Man S, Snegova N, Stefkovicova M, Usonis V,

Wysocki J, Douha M, Vassilev V, Nicholson O, Innis BL, Willems P.

Protection against varicella with two doses of combined measles-mumps-rubella-varicella

vaccine versus one dose of monovalent varicella vaccine: a multicentre, observer-blind,

randomised, controlled trial.

Lancet. 2014

Raffi F, Babiker AG, Richert L, Molina JM, George Ritonavir-boosted darunavir combined with Lancet. 2014

EC, Antinori A, Arribas JR, Grarup J, Hudson F, Schwimmer C, Saillard J, Wallet C, Jansson PO,

Allavena C, Van Leeuwen R, Delfraissy JF, Vella S, Chêne G, Pozniak A; NEAT001/ANRS143 Study

Group.

raltegravir or tenofovir-emtricitabine in antiretroviral-naive adults infected with HIV-1: 96

week results from the NEAT001/ANRS143 randomised non-inferiority trial.

Rangaka MX, Wilkinson RJ, Boulle A, Glynn JR, Fielding K, van Cutsem G, Wilkinson KA, Goliath R,

Mathee S, Goemaere E, Maartens G.

Isoniazid plus antiretroviral therapy to prevent tuberculosis: a randomised double-blind, placebo-

controlled trial.Lancet. 2014

Read RC, Baxter D, Chadwick DR, Faust SN, Finn A, Gordon SB, Heath PT, Lewis DJ, Pollard AJ, Turner DP, Bazaz R, Ganguli A, Havelock T, Neal KR, Okike IO, Morales-Aza B, Patel K, Snape MD, Williams J,

Gilchrist S, Gray SJ, Maiden MC, et al.

Effect of a quadrivalent meningococcal ACWY glycoconjugate or a serogroup B meningococcal vaccine on meningococcal carriage: an observer-

blind, phase 3 randomised clinical trial.

Lancet. 2014

Reddy VY, Sievert H, Halperin J, Doshi SK, Buchbinder M, Neuzil P, Huber K, Whisenant B, Kar S, Swarup V, Gordon N, Holmes D; PROTECT

AF Steering Committee and Investigators.

Percutaneous left atrial appendage closure vs warfarin for atrial fibrillation: a randomized

clinical trial.JAMA. 2014

Regimbeau JM, Fuks D, Pautrat K, Mauvais F, Haccart V, Msika S, Mathonnet M, Scotte M,

Paquet JC, Vons C, Sielezneff I, Millat B, Chiche L, Dupont H, Duhaut P, Cosse C, Diouf M, Pocard M;

FRENCH Study Group.

Effect of postoperative antibiotic administration on postoperative infection following

cholecystectomy for acute calculous cholecystitis: a randomized clinical trial.

JAMA. 2014

Revello MG, Lazzarotto T, Guerra B, Spinillo A, Ferrazzi E, Kustermann A, Guaschino S, Vergani P, Todros T, Frusca T, Arossa A, Furione M, Rognoni

V, Rizzo N, Gabrielli L, Klersy C, Gerna G; CHIP Study Group.

A randomized trial of hyperimmune globulin to prevent congenital cytomegalovirus. N Engl J Med. 2014

Reznik Y, Cohen O, Aronson R, Conget I, Runzis S, Castaneda J, Lee SW; OpT2mise Study Group.

Insulin pump treatment compared with multiple daily injections for treatment of type 2 diabetes (OpT2mise): a randomised open-label controlled

trial.

Lancet. 2014

Rhon DI, Boyles RB, Cleland JA. One-year outcome of subacromial corticosteroid Ann Intern Med. 2014

injection compared with manual physical therapy for the management of the unilateral shoulder

impingement syndrome: a pragmatic randomized trial.

Rice AS, Dworkin RH, McCarthy TD, Anand P, Bountra C, McCloud PI, Hill J, Cutter G, Kitson G,

Desem N, Raff M; EMA401-003 study group.

EMA401, an orally administered highly selective angiotensin II type 2 receptor antagonist, as a novel treatment for postherpetic neuralgia: a randomised, double-blind, placebo-controlled

phase 2 clinical trial.

Lancet. 2014

Richardson LP, Ludman E, McCauley E, Lindenbaum J, Larison C, Zhou C, Clarke G, Brent

D, Katon W.

Collaborative care for adolescents with depression in primary care: a randomized clinical

trial.JAMA. 2014

Richeldi L, du Bois RM, Raghu G, Azuma A, Brown KK, Costabel U, Cottin V, Flaherty KR, Hansell DM, Inoue Y, Kim DS, Kolb M, Nicholson AG, Noble PW,

Selman M, Taniguchi H, Brun M, Le Maulf F, Girard M, Stowasser S, Schlenker-Herceg R, Disse

B, et al.

Efficacy and safety of nintedanib in idiopathic pulmonary fibrosis. N Engl J Med. 2014

Rigotti NA, Regan S, Levy DE, Japuntich S, Chang Y, Park ER, Viana JC, Kelley JH, Reyen M, Singer DE.

Sustained care intervention and postdischarge smoking cessation among hospitalized adults: a

randomized clinical trial.JAMA. 2014

Rintoul RC, Ritchie AJ, Edwards JG, Waller DA, Coonar AS, Bennett M, Lovato E, Hughes V, Fox-

Rushby JA, Sharples LD; MesoVATS Collaborators.

Efficacy and cost of video-assisted thoracoscopic partial pleurectomy versus talc pleurodesis in patients with malignant pleural mesothelioma

(MesoVATS): an open-label, randomised, controlled trial.

Lancet. 2014

RIVUR Trial Investigators, Hoberman A, Greenfield SP, Mattoo TK, Keren R, Mathews R, Pohl HG,

Kropp BP, Skoog SJ, Nelson CP, Moxey-Mims M, Chesney RW, Carpenter MA.

Antimicrobial prophylaxis for children with vesicoureteral reflux. N Engl J Med. 2014

Robert C, Karaszewska B, Schachter J, Rutkowski P, Mackiewicz A, Stroiakovski D, Lichinitser M,

Improved overall survival in melanoma with combined dabrafenib and trametinib. N Engl J Med. 2015

Dummer R, Grange F, Mortier L, Chiarion-Sileni V, Drucis K, Krajsova I, Hauschild A, Lorigan P, Wolter P, Long GV, Flaherty K, Nathan P, Ribas A, Martin

AM, Sun P, et al.Robert C, Long GV, Brady B, Dutriaux C, Maio M,

Mortier L, Hassel JC, Rutkowski P, McNeil C, Kalinka-Warzocha E, Savage KJ, Hernberg MM,

Lebbe C, Charles J, Mihalcioiu C, Chiarion-Sileni V, Mauch C, Cognetti F, Arance A, Schmidt H,

Schadendorf D, Gogas H, et al.

Nivolumab in previously untreated melanoma without BRAF mutation. N Engl J Med. 2015

Robert C, Ribas A, Wolchok JD, Hodi FS, Hamid O, Kefford R, Weber JS, Joshua AM, Hwu WJ,

Gangadhar TC, Patnaik A, Dronca R, Zarour H, Joseph RW, Boasberg P, Chmielowski B, Mateus C,

Postow MA, Gergich K, Elassaiss-Schaap J, Li XN, Iannone R, et al.

Anti-programmed-death-receptor-1 treatment with pembrolizumab in ipilimumab-refractory

advanced melanoma: a randomised dose-comparison cohort of a phase 1 trial.

Lancet. 2014

Robertson CS, Hannay HJ, Yamal JM, Gopinath S, Goodman JC, Tilley BC; Epo Severe TBI Trial

Investigators, Baldwin A, Rivera Lara L, Saucedo-Crespo H, Ahmed O, Sadasivan S, Ponce L, Cruz-

Navarro J, Shahin H, Aisiku IP, Doshi P, Valadka A, Neipert L, Waguspack JM, Rubin ML, Benoit JS, et

al.

Effect of erythropoietin and transfusion threshold on neurological recovery after traumatic brain

injury: a randomized clinical trial.JAMA. 2014

Robinson JG, Nedergaard BS, Rogers WJ, Fialkow J, Neutel JM, Ramstad D, Somaratne R, Legg JC,

Nelson P, Scott R, Wasserman SM, Weiss R; LAPLACE-2 Investigators.

Effect of evolocumab or ezetimibe added to moderate- or high-intensity statin therapy on LDL-C lowering in patients with hypercholesterolemia:

the LAPLACE-2 randomized clinical trial.

JAMA. 2014

Roy-Byrne P, Bumgardner K, Krupski A, Dunn C, Ries R, Donovan D, West II, Maynard C, Atkins DC,

Graves MC, Joesch JM, Zarkin GA.

Brief intervention for problem drug use in safety-net primary care settings: a randomized clinical

trial.JAMA. 2014

Rubertsson S, Lindgren E, Smekal D, Ostlund O, Mechanical chest compressions and simultaneous JAMA. 2014

Silfverstolpe J, Lichtveld RA, Boomars R, Ahlstedt B, Skoog G, Kastberg R, Halliwell D, Box M, Herlitz

J, Karlsten R.

defibrillation vs conventional cardiopulmonary resuscitation in out-of-hospital cardiac arrest: the

LINC randomized trial.Russell SJ, El-Khatib FH, Sinha M, Magyar KL, McKeon K, Goergen LG, Balliro C, Hillard MA,

Nathan DM, Damiano ER.

Outpatient glycemic control with a bionic pancreas in type 1 diabetes. N Engl J Med. 2014

Sacks FM, Carey VJ, Anderson CA, Miller ER 3rd, Copeland T, Charleston J, Harshfield BJ, Laranjo N,

McCarron P, Swain J, White K, Yee K, Appel LJ.

Effects of high vs low glycemic index of dietary carbohydrate on cardiovascular disease risk factors and insulin sensitivity: the OmniCarb

randomized clinical trial.

JAMA. 2014

Saitz R, Palfai TP, Cheng DM, Alford DP, Bernstein JA, Lloyd-Travaglini CA, Meli SM, Chaisson CE,

Samet JH.

Screening and brief intervention for drug use in primary care: the ASPIRE randomized clinical trial. JAMA. 2014

Salloway S, Sperling R, Fox NC, Blennow K, Klunk W, Raskind M, Sabbagh M, Honig LS, Porsteinsson

AP, Ferris S, Reichert M, Ketter N, Nejadnik B, Guenzler V, Miloslavsky M, Wang D, Lu Y, Lull J,

Tudor IC, Liu E, Grundman M, Yuen E, et al.

Two phase 3 trials of bapineuzumab in mild-to-moderate Alzheimer's disease. N Engl J Med. 2014

Sanna T, Diener HC, Passman RS, Di Lazzaro V, Bernstein RA, Morillo CA, Rymer MM, Thijs V, Rogers T, Beckers F, Lindborg K, Brachmann J;

CRYSTAL AF Investigators.

Cryptogenic stroke and underlying atrial fibrillation. N Engl J Med. 2014

Schauer PR, Bhatt DL, Kirwan JP, Wolski K, Brethauer SA, Navaneethan SD, Aminian A, Pothier CE, Kim ES, Nissen SE, Kashyap SR;

STAMPEDE Investigators.

Bariatric surgery versus intensive medical therapy for diabetes--3-year outcomes. N Engl J Med. 2014

Schisterman EF, Silver RM, Lesher LL, Faraggi D, Wactawski-Wende J, Townsend JM, Lynch AM,

Perkins NJ, Mumford SL, Galai N.

Preconception low-dose aspirin and pregnancy outcomes: results from the EAGeR randomised

trial.Lancet. 2014

Schrier RW, Abebe KZ, Perrone RD, Torres VE, Braun WE, Steinman TI, Winklhofer FT, Brosnahan G, Czarnecki PG, Hogan MC, Miskulin DC, Rahbari-

Oskoui FF, Grantham JJ, Harris PC, Flessner MF, Bae KT, Moore CG, Chapman AB; HALT-PKD Trial

Blood pressure in early autosomal dominant polycystic kidney disease.

N Engl J Med. 2014

Investigators.Schuh S, Freedman S, Coates A, Allen U, Parkin PC,

Stephens D, Ungar W, DaSilva Z, Willan AR.Effect of oximetry on hospitalization in

bronchiolitis: a randomized clinical trial. JAMA. 2014

Schulz-Schupke S, Helde S, Gewalt S, Ibrahim T, Linhardt M, Haas K, Hoppe K, Bottiger C, Groha P, Bradaric C, Schmidt R, Bott-Flugel L, Ott I, Goedel J, Byrne RA, Schneider S, Burgdorf C, Morath T,

Kufner S, Joner M, Cassese S, Hoppmann P, et al.

Comparison of vascular closure devices vs manual compression after femoral artery puncture: the

ISAR-CLOSURE randomized clinical trial.JAMA. 2014

Selak V, Elley CR, Bullen C, Crengle S, Wadham A, Rafter N, Parag V, Harwood M, Doughty RN, Arroll

B, Milne RJ, Bramley D, Bryant L, Jackson R, Rodgers A.

Effect of fixed dose combination treatment on adherence and risk factor control among patients at high risk of cardiovascular disease: randomised

controlled trial in primary care.

BMJ. 2014

Shahzad A, Kemp I, Mars C, Wilson K, Roome C, Cooper R, Andron M, Appleby C, Fisher M, Khand A, Kunadian B, Mills JD, Morris JL, Morrison WL,

Munir S, Palmer ND, Perry RA, Ramsdale DR, Velavan P, Stables RH; HEAT-PPCI trial

investigators.

Unfractionated heparin versus bivalirudin in primary percutaneous coronary intervention

(HEAT-PPCI): an open-label, single centre, randomised controlled trial.

Lancet. 2014

Shankaran S, Laptook AR, Pappas A, McDonald SA, Das A, Tyson JE, Poindexter BB, Schibler K, Bell EF, Heyne RJ, Pedroza C, Bara R, Van Meurs KP, Grisby C, Huitema CM, Garg M, Ehrenkranz RA, Shepherd

EG, Chalak LF, Hamrick SE, Khan AM, Reynolds AM, et al.

Effect of depth and duration of cooling on deaths in the NICU among neonates with hypoxic

ischemic encephalopathy: a randomized clinical trial.

JAMA. 2014

Sharpe M, Walker J, Holm Hansen C, Martin P, Symeonides S, Gourley C, Wall L, Weller D, Murray

G; SMaRT (Symptom Management Research Trials) Oncology-2 Team.

Integrated collaborative care for comorbid major depression in patients with cancer (SMaRT

Oncology-2): a multicentre randomised controlled effectiveness trial.

Lancet. 2014

Skolnick BE, Maas AI, Narayan RK, van der Hoop RG, MacAllister T, Ward JD, Nelson NR, Stocchetti

N; SYNAPSE Trial Investigators.

A clinical trial of progesterone for severe traumatic brain injury. N Engl J Med. 2014

Slaghekke F, Lopriore E, Lewi L, Middeldorp JM, van Zwet EW, Weingertner AS, Klumper FJ,

DeKoninck P, Devlieger R, Kilby MD, Rustico MA,

Fetoscopic laser coagulation of the vascular equator versus selective coagulation for twin-to-

twin transfusion syndrome: an open-label Lancet. 2014

Deprest J, Favre R, Oepkes D. randomised controlled trial.Smith PK, Puskas JD, Ascheim DD, Voisine P,

Gelijns AC, Moskowitz AJ, Hung JW, Parides MK, Ailawadi G, Perrault LP, Acker MA, Argenziano M,

Thourani V, Gammie JS, Miller MA, Pagé P, Overbey JR, Bagiella E, Dagenais F, Blackstone EH,

Kron IL, Goldstein DJ, et al.

Surgical treatment of moderate ischemic mitral regurgitation. N Engl J Med. 2014

Smith-Bindman R, Aubin C, Bailitz J, Bengiamin RN, Camargo CA Jr, Corbo J, Dean AJ, Goldstein

RB, Griffey RT, Jay GD, Kang TL, Kriesel DR, Ma OJ, Mallin M, Manson W, Melnikow J, Miglioretti DL,

Miller SK, Mills LD, Miner JR, Moghadassi M, Noble VE, et al.

Ultrasonography versus computed tomography for suspected nephrolithiasis. N Engl J Med. 2014

Smolen JS, Emery P, Fleischmann R, van Vollenhoven RF, Pavelka K, Durez P, Guerette B,

Kupper H, Redden L, Arora V, Kavanaugh A.

Adjustment of therapy in rheumatoid arthritis on the basis of achievement of stable low disease activity with adalimumab plus methotrexate or methotrexate alone: the randomised controlled

OPTIMA trial.

Lancet. 2014

Solomon BJ, Mok T, Kim DW, Wu YL, Nakagawa K, Mekhail T, Felip E, Cappuzzo F, Paolini J, Usari T, Iyer S, Reisman A, Wilner KD, Tursi J, Blackhall F;

PROFILE 1014 Investigators.

First-line crizotinib versus chemotherapy in ALK-positive lung cancer. N Engl J Med. 2014

Speich B, Ame SM, Ali SM, Alles R, Huwyler J, Hattendorf J, Utzinger J, Albonico M, Keiser J.

Oxantel pamoate-albendazole for Trichuris trichiura infection. N Engl J Med. 2014

STABILITY Investigators, White HD, Held C, Stewart R, Tarka E, Brown R, Davies RY, Budaj A, Harrington RA, Steg PG, Ardissino D, Armstrong

PW, Avezum A, Aylward PE, Bryce A, Chen H, Chen MF, Corbalan R, Dalby AJ, Danchin N, De Winter

RJ, Denchev S, et al.

Darapladib for preventing ischemic events in stable coronary heart disease. N Engl J Med. 2014

Stanley TL, Feldpausch MN, Oh J, Branch KL, Lee Effect of tesamorelin on visceral fat and liver fat in JAMA. 2014

H, Torriani M, Grinspoon SK. HIV-infected patients with abdominal fat accumulation: a randomized clinical trial.

Stewart AK, Rajkumar SV, Dimopoulos MA, Masszi T, Spicka I, Oriol A, Hajek R, Rosinol L, Siegel DS, Mihaylov GG, Goranova-Marinova V, Rajnics P,

Suvorov A, Niesvizky R, Jakubowiak AJ, San-Miguel JF, Ludwig H, Wang M, Maisnar V, Minarik J,

Bensinger WI, Mateos MV, et al.

Carfilzomib, lenalidomide, and dexamethasone for relapsed multiple myeloma. N Engl J Med. 2015

Sulkowski MS, Gardiner DF, Rodriguez-Torres M, Reddy KR, Hassanein T, Jacobson I, Lawitz E, Lok

AS, Hinestrosa F, Thuluvath PJ, Schwartz H, Nelson DR, Everson GT, Eley T, Wind-Rotolo M, Huang SP,

Gao M, Hernandez D, McPhee F, Sherman D, Hindes R, Symonds W, et al.

Daclatasvir plus sofosbuvir for previously treated or untreated chronic HCV infection. N Engl J Med. 2014

Sung V, Hiscock H, Tang ML, Mensah FK, Nation ML, Satzke C, Heine RG, Stock A, Barr RG, Wake

M.

Treating infant colic with the probiotic Lactobacillus reuteri: double blind, placebo

controlled randomised trial.BMJ. 2014

Tewari KS, Sill MW, Long HJ 3rd, Penson RT, Huang H, Ramondetta LM, Landrum LM, Oaknin A,

Reid TJ, Leitao MM, Michael HE, Monk BJ.

Improved survival with bevacizumab in advanced cervical cancer. N Engl J Med. 2014

Than M, Aldous S, Lord SJ, Goodacre S, Frampton CM, Troughton R, George P, Florkowski CM, Ardagh M, Smyth D, Jardine DL, Peacock WF,

Young J, Hamilton G, Deely JM, Cullen L, Richards AM.

A 2-hour diagnostic protocol for possible cardiac chest pain in the emergency department: a

randomized clinical trial.JAMA Intern Med. 2014

Torres VE, Abebe KZ, Chapman AB, Schrier RW, Braun WE, Steinman TI, Winklhofer FT, Brosnahan G, Czarnecki PG, Hogan MC, Miskulin DC, Rahbari-

Oskoui FF, Grantham JJ, Harris PC, Flessner MF, Moore CG, Perrone RD; HALT-PKD Trial

Investigators.

Angiotensin blockade in late autosomal dominant polycystic kidney disease. N Engl J Med. 2014

Tremoulet AH, Jain S, Jaggi P, Jimenez-Fernandez S, Pancheri JM, Sun X, Kanegaye JT, Kovalchin JP,

Printz BF, Ramilo O, Burns JC.

Infliximab for intensification of primary therapy for Kawasaki disease: a phase 3 randomised,

double-blind, placebo-controlled trial.Lancet. 2014

Tyrer P, Cooper S, Salkovskis P, Tyrer H, Crawford M, Byford S, Dupont S, Finnis S, Green J, McLaren

E, Murphy D, Reid S, Smith G, Wang D, Warwick H, Petkova H, Barrett B.

Clinical and cost-effectiveness of cognitive behaviour therapy for health anxiety in medical patients: a multicentre randomised controlled

trial.

Lancet. 2014

Vaclavkova A, Chimenti S, Arenberger P, Hollo P, Sator PG, Burcklen M, Stefani M, D'Ambrosio D.

Oral ponesimod in patients with chronic plaque psoriasis: a randomised, double-blind, placebo-

controlled phase 2 trial.Lancet. 2014

Vaidya JS, Wenz F, Bulsara M, Tobias JS, Joseph DJ, Keshtgar M, Flyger HL, Massarut S, Alvarado

M, Saunders C, Eiermann W, Metaxas M, Sperk E, Sutterlin M, Brown D, Esserman L, Roncadin M, Thompson A, Dewar JA, Holtveg HM, Pigorsch S,

Falzon M, et al.

Risk-adapted targeted intraoperative radiotherapy versus whole-breast radiotherapy for breast cancer: 5-year results for local control

and overall survival from the TARGIT-A randomised trial.

Lancet. 2014

Vain NE, Satragno DS, Gorenstein AN, Gordillo JE, Berazategui JP, Alda MG, Prudent LM.

Effect of gravity on volume of placental transfusion: a multicentre, randomised, non-

inferiority trial.Lancet. 2014

van Dongen TM, van der Heijden GJ, Venekamp RP, Rovers MM, Schilder AG.

A trial of treatment for acute otorrhea in children with tympanostomy tubes. N Engl J Med. 2014

van Laar JM, Farge D, Sont JK, Naraghi K, Marjanovic Z, Larghero J, Schuerwegh AJ, Marijt EW, Vonk MC, Schattenberg AV, Matucci-Cerinic M, Voskuyl AE, van de Loosdrecht AA, Daikeler T,

Kötter I, Schmalzing M, Martin T, Lioure B, Weiner SM, Kreuter A, Deligny C, Durand JM, et

al.

Autologous hematopoietic stem cell transplantation vs intravenous pulse

cyclophosphamide in diffuse cutaneous systemic sclerosis: a randomized clinical trial.

JAMA. 2014

van Wijk RM, van Vlimmeren LA, Groothuis-Oudshoorn CG, Van der Ploeg CP, Ijzerman MJ,

Boere-Boonekamp MM.

Helmet therapy in infants with positional skull deformation: randomised controlled trial. BMJ. 2014

van Zanten AR, Sztark F, Kaisers UX, Zielmann S, Felbinger TW, Sablotzki AR, De Waele JJ, Timsit JF,

Honing ML, Keh D, Vincent JL, Zazzo JF, Fijn HB, Petit L, Preiser JC, van Horssen PJ, Hofman Z.

High-protein enteral nutrition enriched with immune-modulating nutrients vs standard high-

protein enteral nutrition and nosocomial infections in the ICU: a randomized clinical trial.

JAMA. 2014

Vermeire S, O'Byrne S, Keir M, Williams M, Lu TT, Mansfield JC, Lamb CA, Feagan BG, Panes J, Salas

Etrolizumab as induction therapy for ulcerative colitis: a randomised, controlled, phase 2 trial. Lancet. 2014

A, Baumgart DC, Schreiber S, Dotan I, Sandborn WJ, Tew GW, Luca D, Tang MT, Diehl L, Eastham-Anderson J, De Hertogh G, Perrier C, Egen JG, et

al.

Villar L, Dayan GH, Arredondo-GarcÃa JL, Rivera DM, Cunha R, Deseda C, Reynales H, Costa MS,

Morales-RamÃrez JO, Carrasquilla G, Rey LC, Dietze R, Luz K, Rivas E, Miranda Montoya MC, Cortés Supelano M, Zambrano B, Langevin E,

Boaz M, Tornieporth N, Saville M, Noriega F; et al.

Efficacy of a tetravalent dengue vaccine in children in Latin America. N Engl J Med. 2015

von Birgelen C, Sen H, Lam MK, Danse PW, Jessurun GA, Hautvast RW, van Houwelingen GK, Schramm AR, Gin RM, Louwerenburg JW, de Man FH, Stoel MG, Lowik MM, Linssen GC, Saïd SA,

Nienhuis MB, Verhorst PM, Basalus MW, Doggen CJ, Tandjung K.

Third-generation zotarolimus-eluting and everolimus-eluting stents in all-comer patients requiring a percutaneous coronary intervention

(DUTCH PEERS): a randomised, single-blind, multicentre, non-inferiority trial.

Lancet. 2014

Vriezinga SL, Auricchio R, Bravi E, Castillejo G, Chmielewska A, Crespo Escobar P, Kolcek S, Koletzko S, Korponay-Szabo IR, Mummert E,

Polanco I, Putter H, Ribes-Koninckx C, Shamir R, Szajewska H, Werkstetter K, Greco L, Gyimesi J,

Hartman C, Hogen Esch C, Hopman E, Ivarsson A, et al.

Randomized feeding intervention in infants at high risk for celiac disease. N Engl J Med. 2014

Wagner JE Jr, Eapen M, Carter S, Wang Y, Schultz KR, Wall DA, Bunin N, Delaney C, Haut P, Margolis

D, Peres E, Verneris MR, Walters M, Horowitz MM, Kurtzberg J; Blood and Marrow Transplant

Clinical Trials Network.

One-unit versus two-unit cord-blood transplantation for hematologic cancers. N Engl J Med. 2014

Wald A, Corey L, Timmler B, Magaret A, Warren T, Tyring S, Johnston C, Kriesel J, Fife K, Galitz L,

Stoelben S, Huang ML, Selke S, Stobernack HP,

Helicase-primase inhibitor pritelivir for HSV-2 infection. N Engl J Med. 2014

Ruebsamen-Schaeff H, Birkmann A.Walker N, Howe C, Glover M, McRobbie H, Barnes

J, Nosa V, Parag V, Bassett B, Bullen C. Cytisine versus nicotine for smoking cessation. N Engl J Med. 2014

Weir MR, Bakris GL, Bushinsky DA, Mayo MR, Garza D, Stasiv Y, Wittes J, Christ-Schmidt H,

Berman L, Pitt B; OPAL-HK Investigators.

Patiromer in patients with kidney disease and hyperkalemia receiving RAAS inhibitors. N Engl J Med. 2015

Williams CM, Maher CG, Latimer J, McLachlan AJ, Hancock MJ, Day RO, Lin CW.

Efficacy of paracetamol for acute low-back pain: a double-blind, randomised controlled trial. Lancet. 2014

Williamson JD, Launer LJ, Bryan RN, Coker LH, Lazar RM, Gerstein HC, Murray AM, Sullivan MD,

Horowitz KR, Ding J, Marcovina S, Lovato L, Lovato J, Margolis KL, Davatzikos C, Barzilay J, Ginsberg

HN, Linz PE, Miller ME; Action to Control Cardiovascular Risk in Diabetes Memory in

Diabetes Investigators.

Cognitive function and brain structure in persons with type 2 diabetes mellitus after intensive lowering of blood pressure and lipid levels: a

randomized clinical trial.

JAMA Intern Med. 2014

Wills AM, Hubbard J, Macklin EA, Glass J, Tandan R, Simpson EP, Brooks B, Gelinas D, Mitsumoto H,

Mozaffar T, Hanes GP, Ladha SS, Heiman-Patterson T, Katz J, Lou JS, Mahoney K, Grasso D,

Lawson R, Yu H, Cudkowicz M; MDA Clinical Research Network.

Hypercaloric enteral nutrition in patients with amyotrophic lateral sclerosis: a randomised,

double-blind, placebo-controlled phase 2 trial.Lancet. 2014

Wright DW, Yeatts SD, Silbergleit R, Palesch YY, Hertzberg VS, Frankel M, Goldstein FC, Caveney AF, Howlett-Smith H, Bengelink EM, Manley GT,

Merck LH, Janis LS, Barsan WG; NETT Investigators.

Very early administration of progesterone for acute traumatic brain injury. N Engl J Med. 2014

Zeuzem S, Dusheiko GM, Salupere R, Mangia A, Flisiak R, Hyland RH, Illeperuma A, Svarovskaia E,

Brainard DM, Symonds WT, Subramanian GM, McHutchison JG, Weiland O, Reesink HW, Ferenci P, Hézode C, Esteban R; VALENCE Investigators.

Sofosbuvir and ribavirin in HCV genotypes 2 and 3. N Engl J Med. 2014

Zeuzem S, Jacobson IM, Baykal T, Marinho RT, Poordad F, Bourliere M, Sulkowski MS,

Retreatment of HCV with ABT-450/r-ombitasvir and dasabuvir with ribavirin. N Engl J Med. 2014

Wedemeyer H, Tam E, Desmond P, Jensen DM, Di Bisceglie AM, Varunok P, Hassanein T, Xiong J,

Pilot-Matias T, DaSilva-Tillmann B, Larsen L, Podsadecki T, Bernstein B.

Zhu AX, Kudo M, Assenat E, Cattan S, Kang YK, Lim HY, Poon RT, Blanc JF, Vogel A, Chen CL, Dorval E,

Peck-Radosavljevic M, Santoro A, Daniele B, Furuse J, Jappe A, Perraud K, Anak O, Sellami DB,

Chen LT.

Effect of everolimus on survival in advanced hepatocellular carcinoma after failure of

sorafenib: the EVOLVE-1 randomized clinical trial.JAMA. 2014

Zhu F, Xu W, Xia J, Liang Z, Liu Y, Zhang X, Tan X, Wang L, Mao Q, Wu J, Hu Y, Ji T, Song L, Liang Q, Zhang B, Gao Q, Li J, Wang S, Hu Y, Gu S, Zhang J,

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