Dunblane Nursery Curriculum Evening Learning through play 23 rd September 2015.
APRICOT & SPAN Dunblane, 25 April 2014. APRICOT - SPAN Overview What is APRICOT? Why SPAN? How to...
-
Upload
dorcas-parrish -
Category
Documents
-
view
220 -
download
0
Transcript of APRICOT & SPAN Dunblane, 25 April 2014. APRICOT - SPAN Overview What is APRICOT? Why SPAN? How to...
![Page 1: APRICOT & SPAN Dunblane, 25 April 2014. APRICOT - SPAN Overview What is APRICOT? Why SPAN? How to participate Results & follow-up.](https://reader035.fdocuments.net/reader035/viewer/2022062407/56649e605503460f94b5b54a/html5/thumbnails/1.jpg)
APRICOT & SPAN
Dunblane, 25 April 2014
![Page 2: APRICOT & SPAN Dunblane, 25 April 2014. APRICOT - SPAN Overview What is APRICOT? Why SPAN? How to participate Results & follow-up.](https://reader035.fdocuments.net/reader035/viewer/2022062407/56649e605503460f94b5b54a/html5/thumbnails/2.jpg)
APRICOT - SPAN
Overview• What is APRICOT?• Why SPAN?• How to participate• Results & follow-up
![Page 3: APRICOT & SPAN Dunblane, 25 April 2014. APRICOT - SPAN Overview What is APRICOT? Why SPAN? How to participate Results & follow-up.](https://reader035.fdocuments.net/reader035/viewer/2022062407/56649e605503460f94b5b54a/html5/thumbnails/3.jpg)
APRICOT
[email protected]@gmail.com
Anaesthesia Practice In Children Observational Trial
European prospective multicenter observational study: Epidemiology of severe critical events
![Page 4: APRICOT & SPAN Dunblane, 25 April 2014. APRICOT - SPAN Overview What is APRICOT? Why SPAN? How to participate Results & follow-up.](https://reader035.fdocuments.net/reader035/viewer/2022062407/56649e605503460f94b5b54a/html5/thumbnails/4.jpg)
APRICOT
Aims
• Incidence of severe critical events in children undergoing anesthesia in Europe
• Differences in paediatric anaesthesia practice• Impact of this variability on the occurrence of severe
critical events • Improve the quality and safety of anaesthesia in
children
![Page 5: APRICOT & SPAN Dunblane, 25 April 2014. APRICOT - SPAN Overview What is APRICOT? Why SPAN? How to participate Results & follow-up.](https://reader035.fdocuments.net/reader035/viewer/2022062407/56649e605503460f94b5b54a/html5/thumbnails/5.jpg)
APRICOT
DesignProspective, observational, multi–centre cohort study
Inclusion
All children (0-16 years) admitted for any elective/non-elective inpatient or outpatient procedure (general anaesthesia, sedation with or without regional analgesia)
ExclusionChildren admitted to theatres from PICU or procedures in PICU/NICU(include if spontaneous ventilation or non-intubated on CPAP)
![Page 6: APRICOT & SPAN Dunblane, 25 April 2014. APRICOT - SPAN Overview What is APRICOT? Why SPAN? How to participate Results & follow-up.](https://reader035.fdocuments.net/reader035/viewer/2022062407/56649e605503460f94b5b54a/html5/thumbnails/6.jpg)
APRICOT
Primary Endpoint
Incidence of severe critical events during and up to 60 minutes after anaesthesia
![Page 7: APRICOT & SPAN Dunblane, 25 April 2014. APRICOT - SPAN Overview What is APRICOT? Why SPAN? How to participate Results & follow-up.](https://reader035.fdocuments.net/reader035/viewer/2022062407/56649e605503460f94b5b54a/html5/thumbnails/7.jpg)
Severe critical events
Laryngospasm Bronchospasm
Stridor Pulmonary aspiration
Drug error Anaphylaxis
Cardiovascular instability Cardiac arrest
Neurological damage
![Page 8: APRICOT & SPAN Dunblane, 25 April 2014. APRICOT - SPAN Overview What is APRICOT? Why SPAN? How to participate Results & follow-up.](https://reader035.fdocuments.net/reader035/viewer/2022062407/56649e605503460f94b5b54a/html5/thumbnails/8.jpg)
DefinitionsSevere critical events (CRF 1.4)
![Page 9: APRICOT & SPAN Dunblane, 25 April 2014. APRICOT - SPAN Overview What is APRICOT? Why SPAN? How to participate Results & follow-up.](https://reader035.fdocuments.net/reader035/viewer/2022062407/56649e605503460f94b5b54a/html5/thumbnails/9.jpg)
APRICOT
Primary EndpointIncidence of severe critical events during and up to 60 minutes after anaesthesia
Secondary EndpointsRisk factorsConsequences/ outcomes
Sample Size25,000 children Europe wide
![Page 10: APRICOT & SPAN Dunblane, 25 April 2014. APRICOT - SPAN Overview What is APRICOT? Why SPAN? How to participate Results & follow-up.](https://reader035.fdocuments.net/reader035/viewer/2022062407/56649e605503460f94b5b54a/html5/thumbnails/10.jpg)
Sponsor & CI
ESA Clinical Trials NetworkChief Investigator: Prof Walid HabreUK National Coordinator: Dr Neil Morton
![Page 11: APRICOT & SPAN Dunblane, 25 April 2014. APRICOT - SPAN Overview What is APRICOT? Why SPAN? How to participate Results & follow-up.](https://reader035.fdocuments.net/reader035/viewer/2022062407/56649e605503460f94b5b54a/html5/thumbnails/11.jpg)
Endorsements- ESPA
- Association of Paediatric Anaesthetists of Great Britain and Ireland (APAGBI)
- Association of French speaking Paediatric Anaesthetists and Intensivists (Association des Anesthésiste-Réanimateurs Pédiatriques d’expression française (ADARPEF-),
- Swiss Society for Paediatric Anaesthesiology (Schweizerische Gesellschaft für Kinderanästhesie / Société Suisse d’Anesthésiologie Pédiatrique (SGKA/SSAP)),
- Italian Society for Paediatric and Neonatal Anaesthesia and Intensive Care (La Società di Anestesia e Rianimazione Neonatale e Pediatrica Italiana (S.A.R.N.eP.I.)),
- German Society of Anesthesiology and Intensive Care Medicine (Deutsche Gesellschaft für Anästhesiologie und lntensivmedizin e.V." (DGAI)),
- The Belgian Association for Paediatric Anaesthesiology (BAPA),
- Society of Anesthesia and Resuscitation of Belgium (SARB),
- Austrian Society of Anesthesiology (Österreichische Gesellschaft für Anaesthesiologie, Reanimation und Intensivmedizin) (ÖGARI),
- Hellenic Society of Anaesthesiology - Greece (EAE)
- Ukrainian Society of Anesthesiologists - Ассоциация анестезиологов Украины – Ukraine (AAY)
![Page 12: APRICOT & SPAN Dunblane, 25 April 2014. APRICOT - SPAN Overview What is APRICOT? Why SPAN? How to participate Results & follow-up.](https://reader035.fdocuments.net/reader035/viewer/2022062407/56649e605503460f94b5b54a/html5/thumbnails/12.jpg)
Centres
>300 centres72 UK centresAll Scottish centres in SPAN signed up
![Page 13: APRICOT & SPAN Dunblane, 25 April 2014. APRICOT - SPAN Overview What is APRICOT? Why SPAN? How to participate Results & follow-up.](https://reader035.fdocuments.net/reader035/viewer/2022062407/56649e605503460f94b5b54a/html5/thumbnails/13.jpg)
UK Study conditions
Observational non-research studyData anonymised and protectedEthics waiverWaiver of individual patient consentCaldicott guardian and R&D approvalsFamily information leaflets and posters
![Page 14: APRICOT & SPAN Dunblane, 25 April 2014. APRICOT - SPAN Overview What is APRICOT? Why SPAN? How to participate Results & follow-up.](https://reader035.fdocuments.net/reader035/viewer/2022062407/56649e605503460f94b5b54a/html5/thumbnails/14.jpg)
WHY SPAN ?
• Unique national picture to inform and educate for the future
• Opportunity to measure against the whole European dataset
• Plan & model future studies SPAN/ UK / Europe
![Page 15: APRICOT & SPAN Dunblane, 25 April 2014. APRICOT - SPAN Overview What is APRICOT? Why SPAN? How to participate Results & follow-up.](https://reader035.fdocuments.net/reader035/viewer/2022062407/56649e605503460f94b5b54a/html5/thumbnails/15.jpg)
WHO has signed up?
![Page 16: APRICOT & SPAN Dunblane, 25 April 2014. APRICOT - SPAN Overview What is APRICOT? Why SPAN? How to participate Results & follow-up.](https://reader035.fdocuments.net/reader035/viewer/2022062407/56649e605503460f94b5b54a/html5/thumbnails/16.jpg)
HOW to participate
• Initial steps – registration (ESA/AAGBI membership)
• Date setting01 April 2014 - 31 December 2014
• Ethics not required – Audit (WOSRES)• Caldicott• Paper work and logistical issues
![Page 17: APRICOT & SPAN Dunblane, 25 April 2014. APRICOT - SPAN Overview What is APRICOT? Why SPAN? How to participate Results & follow-up.](https://reader035.fdocuments.net/reader035/viewer/2022062407/56649e605503460f94b5b54a/html5/thumbnails/17.jpg)
Everyone needs to be involved!(but only for 2 weeks)
![Page 18: APRICOT & SPAN Dunblane, 25 April 2014. APRICOT - SPAN Overview What is APRICOT? Why SPAN? How to participate Results & follow-up.](https://reader035.fdocuments.net/reader035/viewer/2022062407/56649e605503460f94b5b54a/html5/thumbnails/18.jpg)
Paperwork
• Email from ESA confirming registration– Your contact details including ESA/AAGBI membership
• Site questionnaire (www.surveymonkey.com/s/APRICOTSTUDY )
• Cover sheet, WOSRES notification, Information leaflet
![Page 19: APRICOT & SPAN Dunblane, 25 April 2014. APRICOT - SPAN Overview What is APRICOT? Why SPAN? How to participate Results & follow-up.](https://reader035.fdocuments.net/reader035/viewer/2022062407/56649e605503460f94b5b54a/html5/thumbnails/19.jpg)
Cover sheet, WOSRES, Information
![Page 20: APRICOT & SPAN Dunblane, 25 April 2014. APRICOT - SPAN Overview What is APRICOT? Why SPAN? How to participate Results & follow-up.](https://reader035.fdocuments.net/reader035/viewer/2022062407/56649e605503460f94b5b54a/html5/thumbnails/20.jpg)
Paperwork
• Email from ESA confirming registration• Site questionnaire (www.surveymonkey.com/s/APRICOTSTUDY )
• Cover sheet, WOSRES notification, Information leaflet• ESA /UK notification of start date (8 days minimum)
• Case Report Form (CRF 1.4.1) – print one per patient
![Page 21: APRICOT & SPAN Dunblane, 25 April 2014. APRICOT - SPAN Overview What is APRICOT? Why SPAN? How to participate Results & follow-up.](https://reader035.fdocuments.net/reader035/viewer/2022062407/56649e605503460f94b5b54a/html5/thumbnails/21.jpg)
• Cover per patient
Case Report Form - v 1.4.1 only
![Page 22: APRICOT & SPAN Dunblane, 25 April 2014. APRICOT - SPAN Overview What is APRICOT? Why SPAN? How to participate Results & follow-up.](https://reader035.fdocuments.net/reader035/viewer/2022062407/56649e605503460f94b5b54a/html5/thumbnails/22.jpg)
Case Report Form - v 1.4.1 only
• Cover• Preoperative data• Intraoperative data• Perioperative complications• Postanaesthetic data
![Page 23: APRICOT & SPAN Dunblane, 25 April 2014. APRICOT - SPAN Overview What is APRICOT? Why SPAN? How to participate Results & follow-up.](https://reader035.fdocuments.net/reader035/viewer/2022062407/56649e605503460f94b5b54a/html5/thumbnails/23.jpg)
• Cover• Preoperative data– Demographics– Medical history– Indication– Anaesthesia Plan
Case Report Form - v 1.4.1 only
![Page 24: APRICOT & SPAN Dunblane, 25 April 2014. APRICOT - SPAN Overview What is APRICOT? Why SPAN? How to participate Results & follow-up.](https://reader035.fdocuments.net/reader035/viewer/2022062407/56649e605503460f94b5b54a/html5/thumbnails/24.jpg)
• Cover• Preoperative data• Intraoperative data– Type of anaesthesia (sedation, GA, RA)– Airway management– Ventilation– Fluids– Timing
Case Report Form - v 1.4.1 only
![Page 25: APRICOT & SPAN Dunblane, 25 April 2014. APRICOT - SPAN Overview What is APRICOT? Why SPAN? How to participate Results & follow-up.](https://reader035.fdocuments.net/reader035/viewer/2022062407/56649e605503460f94b5b54a/html5/thumbnails/25.jpg)
• Cover• Preoperative data• Intraoperative data• Perioperative complications
Case Report Form - v 1.4.1 only
![Page 26: APRICOT & SPAN Dunblane, 25 April 2014. APRICOT - SPAN Overview What is APRICOT? Why SPAN? How to participate Results & follow-up.](https://reader035.fdocuments.net/reader035/viewer/2022062407/56649e605503460f94b5b54a/html5/thumbnails/26.jpg)
• Cover• Preoperative data• Intraoperative data• Perioperative complications• Postanaesthetic data
Case Report Form - v 1.4.1 only
![Page 27: APRICOT & SPAN Dunblane, 25 April 2014. APRICOT - SPAN Overview What is APRICOT? Why SPAN? How to participate Results & follow-up.](https://reader035.fdocuments.net/reader035/viewer/2022062407/56649e605503460f94b5b54a/html5/thumbnails/27.jpg)
Paperwork
• Email from ESA confirming registration• Cover sheet, WOSRES notification• Site questionnaire (www.surveymonkey.com/s/APRICOTSTUDY )
• ESA /UK notification of start date (8 days minimum)
• Case Report Form (CRF 1.4) – print one per patient • eCRF upload (Open Clinica electronic CRF)
• FAQ – in email response from ESA
![Page 28: APRICOT & SPAN Dunblane, 25 April 2014. APRICOT - SPAN Overview What is APRICOT? Why SPAN? How to participate Results & follow-up.](https://reader035.fdocuments.net/reader035/viewer/2022062407/56649e605503460f94b5b54a/html5/thumbnails/28.jpg)
FAQ
![Page 29: APRICOT & SPAN Dunblane, 25 April 2014. APRICOT - SPAN Overview What is APRICOT? Why SPAN? How to participate Results & follow-up.](https://reader035.fdocuments.net/reader035/viewer/2022062407/56649e605503460f94b5b54a/html5/thumbnails/29.jpg)
Results & Follow-up
Overall results to paper for LancetBenchmarking against overall results– by country– by centre– opportunity for complete national picture for Scotland
QI projects (pain management and others)
![Page 30: APRICOT & SPAN Dunblane, 25 April 2014. APRICOT - SPAN Overview What is APRICOT? Why SPAN? How to participate Results & follow-up.](https://reader035.fdocuments.net/reader035/viewer/2022062407/56649e605503460f94b5b54a/html5/thumbnails/30.jpg)
Contacts & copies of talk
Dr Lesley McKee: [email protected] Neil Morton: [email protected] Dr Thomas Engelhardt: [email protected]
![Page 31: APRICOT & SPAN Dunblane, 25 April 2014. APRICOT - SPAN Overview What is APRICOT? Why SPAN? How to participate Results & follow-up.](https://reader035.fdocuments.net/reader035/viewer/2022062407/56649e605503460f94b5b54a/html5/thumbnails/31.jpg)
APA - SPA joint meetingAberdeen, Scotland 14-15th May 2015
CCAN - CCAS joint meeting Aberdeen, Scotland 13th May 2015