Appropriate Use of Antipsychotics in Dementia · Antipsychotics are NOT Effective for Responsive...
Transcript of Appropriate Use of Antipsychotics in Dementia · Antipsychotics are NOT Effective for Responsive...
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What is all the fuss?
Appropriate Use of Antipsychotics in Dementia
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Antipsychotics• First produced in 50’s for schizophrenia• Later also used for:
- other psychiatric disorders- behaviours related to dementia
Typical
• haloperidol (Haldol)• chlorpromazine(Largactil)• trifluoperphenazine (Stelazine)
Atypical
• risperiodone (Risperdal)• quetiapine (Seroquel)• olanzapine (Zyprexa)• aripiprazole (Abilify)
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Appropriate Use of AntipsychoticsConfirmed mental health diagnosis:
• Schizophrenia, Huntington’s Chorea• Major refractory depression, bipolar, delusional
disorder, some anxiety and personality disorders• Distressing psychosis (hallucinations or delusions)
Short term use in dementia: • Brief Psychotic Disorder (e.g. delirium)• Physical aggression – risk of injury to self or others
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Expected Progression of Dementia.
Late stageLose speechMoving difficultyIncontinentSwallowing issuesNeed help with all care
Middle stageGetting lostDelusionsHallucinationsAgitation/AnxietyAggressionDepressionMay hurt self or others
Early stageMemory lossLanguage difficultiesIrritableWithdrawnAbusive languageMood swings
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Words used to DescribeBehaviours related to Dementia
• Behavioural and psychological symptoms of dementia (BPSD)
• Neuropsychiatric symptoms (NPS)
• Challenging Behaviours
• Responsive Behaviours
- what is the person responding too?
• Expressive Behaviours - what is the person trying to tell us?
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Responsive Behaviours - Possible Causes
Socio-environmental• Over/under stimulation• Overcrowding• Inconsistent routine• Provocation by others
Biological• Delirium• Disease process• Medications
Physical• Pain• Elimination• Fatigue• Hunger• Thirst• Hot or cold
Psychological•↓ Stress threshold• Loneliness• Depression• Relationships
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Antipsychotics are NOT Effectivefor Responsive Behaviors such as:
• Calling out, repetitive questions• Wandering, exit-seeking• Inappropriate elimination• Eating inedibles (soap, dirt, feces)• Interfering with other residents• Perseveration (clapping, tapping)• Inappropriate dressing/undressing
• Socially inappropriate• Hiding/hoarding items• Insomnia• Spitting• Crying• Fidgeting• Nervousness/restlessness
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Health Canada Warnings
Heart failure Sudden cardiac death Stroke Infection (mostly pneumonia: 60% increased risk)
Health Canada has issued warnings (2002, 2004, 2005, 2015) of increased risk to elderly patients who take antipsychotics including:
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Antipsychotic Hazards• Extrapyramidal Symptoms (EPS):
tremor, leaning, stiffness, swallowing problems, cog-wheeling (jerky limb movements)
• Tardive Dyskinesia (TD):lip-smacking, facial grimacing, jaw swinging, tongue thrusting
• Neuroleptic Malignant Syndrome: high fever, rigidity, reduced level of consciousness, rapid heart rate and arrhythmias
• Impaired cognition
• Impaired mobility
• Falls
• Diabetes
• Increased lipids
• Akathisia – inner restlessnessor need for constant motion
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Potential Side Effects of Antipsychotics• Confusion, agitation, sleepiness • Nervousness, sleep disturbances• Blurred vision, dizziness, orthostatic
hypotension• Muscle stiffness and weakness• Pain in the arms, legs, back or joints• Hyper-salivation: Drooling, spitting,
difficulty swallowing• Nausea, heartburn, loss of appetite,
stomach pain• Difficulty urinating, acute kidney injury
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Appropriate Use of AntipsychoticsClear role in:
• Schizophrenia*, Schizoaffective Disorder• Delusional Disorder• Huntington’s Chorea*• Brief Psychotic Disorder (e.g. troublesome
hallucinations and delusions* from delirium)- Use SHORT time (weeks not months or years)
• Aggression and severe agitation- Use short term, when nothing else works
*RAI 2.0 QI AUA definitions
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Key MessagesAppropriate Use of Antipsychotic in dementia means:• Always consider other alternatives first • Involve the family or alternate decision maker • Use only when clinically indicated / absolutely necessary • Start low and go slow; monitor closely• Reduce / discontinue as quickly as possible
The care team needs to always ask:• What is the reason for the behaviour?• What else can we try?
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SCNs re-shape health care: • Focus on what Albertans need• Use scientific evidence to guide care decisions• Support good care approaches across the province
In collaboration with: Front-line physicians and clinicians, zone/clinical leaders, researchers, content experts, public, families, patients
For more information, search SCN on the AHS External or Internal websites
Part II - AUA Project OverviewWho leads the AUA Project?
Seniors Health Strategic Clinical Network (SCN) in Collaboration with Addiction & Mental Health SCN
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Seniors Health SCN
Platforms and Pillars for Success
Appropriate Use of Antipsychotics (AUA) project
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Phase 1: Guideline & Toolkit
Alberta AUA Guideline
• Assess the behaviour- treat underlying cause(s)
• Try non-pharmacologic alternatives
• Required medication reviews/assessments
• Involve family/alternate decision maker
AUA Toolkit• Assessment tools• Medication review requirements• Prescribing information• Family information • Resources to support medication
reduction/discontinuation
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AUA ToolkitGoogle
AUA Toolkitor
Search on AHS External Web
http://www.albertahealthservices.ca/auatoolkit.asp
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Phase 2: Early Adopter Sites
0.0
5.0
10.0
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20.0
25.0
30.0
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Baseline Jun 2013 Jul Aug Sept Oct Nov Dec Jan.2014 Feb Mar
41% 40%
34%31%
28%26%
23%21% 21% 21.5%
11 units: average antipsychotic medication use
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0%
10%
20%
30%
40%
50%
60%
70%
80%
27%
34%
75%
22%26%
50%
40%
77%
44%39%
17%
0%
17%
29%
11.5% 11%
15.9%
26%
58.6%
32% 33%
2%
% o
f res
iden
ts o
n an
tipsy
chot
ics
Early Adopter Sites Jun 2013 – Mar 2014Unit Level Data on Antipsychotic Medication use
Baseline Jun 2013
Mar-14
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41%40%
34%31%
28% 26%23%
21% 21% 21.5%
36%
46%51%
56%
76%
85%89% 90%
83%87%
0
10
20
30
40
50
60
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Baseline Jun 2013 Jul Aug Sept Oct Nov Dec Jan-14 Feb Mar
%
Percent of Residents on Antipsychotics & with a Monthly Medication Review
% of residents on Antipsychotics
% of monthly med reviews
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Stories from Care TeamsFamilies report: • Increased communication, more alert• More independent – e.g. feeding self
Staff report: • Units quieter now• Easier to provide care to residents• Fewer falls• Encouraged to see front line staff more
involved in problem solving
Administrators report:• Downward trend in medication costs
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Family, Staff & Resident ExperiencesMarshall and Evelyn ByeBow View Manor, Calgary
Yvonne VerlindeYouville Home, St. Albert
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Phase 3: Provincial Implementation
AUA Project resources were shared with all 170 LTC sites in Alberta in 2014/15. Antipsychotic use continues to decline.
34.7%
22.0%
34.8%
22.5%
34.5%
25.7%
29.1%
16.3%
26.7%
17.2%
28.8%
19.8%
0.0%
5.0%
10.0%
15.0%
20.0%
25.0%
30.0%
35.0%
40.0%
North Zone Edmonton Zone Central Zone Calgary Zone South Zone Alberta
Percen
tage of R
esiden
ts on An
tipsychotics a
s pe
r CIHI d
efinition
2013 Q2
2013 Q3
2013 Q4
2014 Q1
2014 Q2
2014 Q3
2014 Q4
2015 Q1