Appropriate Opioid Prescribing for Acute Pain after...
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Appropriate Opioid Prescribing
for Acute Pain after Surgery
Richard J. Barth Jr.Professor of Surgery
Chief, Section of General SurgeryDartmouth Hitchcock Medical Center
Clinical Trials Network WebinarFebruary 13, 2018
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The faces of the opioid epidemic in NH
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The Opioid Epidemic: Introduction
Prescription opioid deaths quadrupled in last 15 years
Overdoses now leading cause of injury related deaths
19,000 die in US annually, 400 in NH (2016)
Opioid prescribing has also quadrupled in the past 15 years and is highly prevalent:
82.5 prescriptions per 100 persons per year
Dart R. NEJM 2015; 372: 241
Paulozzi L. J Saf Res 2014; 51: 125.
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Link between increased opioid prescribing and increasing
opioid overdose deaths…
• FDA and Surgeon General: “The crisis will
continue unabated unless clinicians stop
prescribing opioids far in excess of clinical
need.”
Califf R. NEJM 2016; 374: 1480
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Surgeons play an important role in the opioid epidemic
Surgeons commonly prescribe opioids after surgery
Prescribing opioids for our patients has risks for them:
• People who undergo general surgical operations (breast surgery,
cholecystectomy) have a relative risk 2-3 X higher than the general
population of becoming chronic opioid users.
• 5-10% of opioid naïve patients become chronic users after prescribed
opioids for surgery.
The pills our patients don’t use can be used by others:
• Diversion: 71% of users get drugs by diversion.
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5-10% of opioid naïve patients become chronic
users after prescribed opioids for surgery
Study N % chronic users Definition
Alam 2012 390,000 7 On opioids 1 year after
surgery
Deyo 2016 536,000 5 >5 refills subsequent year
Johnson 2016 59,000 13 New script 90-180 days
after surgery
Brummet 2017 55,000 6 New script 90-180 days
after surgery
Jiang 2017 79,000 9 On opioids 90 days after
surgery
Shah 2017 1,295,000 5 On opioids 1 year after
surgery
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The Problem for Surgeons
Concern for individual patient
Tendency to overprescribe:
Want to minimize acute post-operative pain
Avoid need for patients to have to return to clinic for a refill prescription
Responsibility for population health
Minimize diversion, overdose, and addiction
Clinicians need to limit prescriptions
Provide patients with lowest practical dose
What is the balance?
What is the ideal number to prescribe?
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Literature Review: 2015
Few studies exist that address optimal post-operative opioid prescriptions
• Urologic, oral, hand, and upper extremity surgery
No studies looking at best prescribing practices in general surgery
J Oral Maxillofac Surg 71:1500-1503, 2013
J Hand Surg Am. 2012;37A:645–650
J Hand Surg Am. 2015;40(2):341e346
J Urology. 2011. 185: 551-555
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Ann Surg 2017, 265: 709-14
Ann Surg 2017, in press
J Am Col Surg., 2017 in press.
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Methods
• The 5 most common outpatient procedures performed June-Dec 2015:
partial mastectomy, partial mastectomy with sentinel lymph node biopsy,
laparoscopic cholecystectomy, laparoscopic inguinal hernia repair, open
inguinal hernia repair
• Post-operative opioid prescription data and opioid refill data were obtained
• Patients with recent opioid use, history of opioid abuse, and those with post-operative complications were excluded
• We called patients and asked them how many opioids they took.
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Partial
Mastectomy
Partial Mastectomy
with Sentinel
Lymph Node
Laparoscopic
Cholecystectomy
Laparoscopic
Inguinal
Hernia Repair
Open Unilateral
Inguinal Hernia
Repair
ALL CASES
Cases
Performed
183 112 240 80 85 700
Number
Patients
Excluded
8 8 32 4 6 58 (8%)
Chronic
opioid use/
abuse
2 5 24 3 4 38 (5%)
Complications
6 3 6 1 2 18 (3%)
Patients
Analyzed
175 104 208 76 79 642
Cases Performed and Analyzed
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PM (175) PM SLNB
(104)
LC (208) LIH (76) IH (79)
Patients Receiving
Opioid Prescription
129
(73.7%)
92
(88.5%)
205
(98.6%)
76
(100%)
79
(100%)
Opioid Pills
Prescribed
Mean 19.8 23.7 35.2 33.8 33.2
Median 20 20 30 30 30
Range 0-50 0-60 0-100 15-70 15-120
Opioid Prescriptions
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0
10
20
30
40
50
60
70
80
0 1-5 6-10 11-15 16-20 21-25 26-30 31-35 36-40 41-45 46-50
Pe
rce
nt
Su
rve
ye
d P
op
ult
ion
Pills Taken
B
Frequency of opioids prescribed (A) and taken (B)
after partial mastectomy
N=175
Median= 20
Range= 0-50
0
5
10
15
20
25
30
0 1-5 6-10 11-15 16-20 21-25 26-30 31-35 36-40 41-45 46-50
Pe
rce
nt
To
tal P
op
ula
tio
n
Pills Prescribed
A
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0
5
10
15
20
25
0 1-5 6-10 11-15 16-20 21-25 36-30 31-35 36-40 41-45 46-50 51-55 56-60
Pe
rce
nt
To
tal P
op
ula
tio
n
Pills Prescriped
0
10
20
30
40
50
60
0 1-5 6-10 11-20 21-25 26-30 31-35 35-40 41-45 45-50 51-55 56-60
Pe
rce
nt
Su
rve
ye
d P
op
ula
tio
n
Pills Taken
Frequency of opioids prescribed (A) and taken (B)
after partial mastectomy with sentinel lymph node biopsy
A
B
N=104
Median= 20
Range= 0-60
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0
5
10
15
20
25
30
35
40
Pe
rce
nt
To
tal P
op
ula
toin
Pills Prescribed
0
5
10
15
20
25
30
35
Pe
rce
nt
Su
rve
ye
d P
op
ula
tio
n
Pills Taken
Frequency of opioids prescribed (A) and taken (B)
after laparoscopic cholecystectomy
A
B
N=208
Median= 30
Range= 0-100
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0
10
20
30
40
50
60
0 1-5 6-10 11-15 16-20 21-25 26-30 31-35 36-40 41-45 46-50 51-55 56-60 61-65 66-70
Pe
rce
nt
To
tal P
op
ula
tio
n
Pills Prescribed
0
10
20
30
40
50
0 1-5 6-10 11-15 16-20 21-25 26-30 31-35 36-40 41-45 46-50 51-55 56-60 61-65 66-70
Pe
rce
nt
Su
rve
ye
d P
op
ula
tio
n
Pills Taken
N=76
Median= 30
Range= 15-70
Frequency of opioids prescribed (A) and taken (B)
after laparoscopic inguinal hernia repair
A
B
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0
10
20
30
40
50
Pe
rce
nt
To
tal P
op
ula
tio
n
Pills Prescribed
0
10
20
30
40
Pe
rce
nt
Su
rve
ye
d P
op
ula
tio
n
Pills Taken
Frequency of opioids prescribed (A) and taken (B)
after unilateral open inguinal hernia repair
A
B
N=79
Median= 30
Range= 15-120
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Home Opioid Use Summary:
Only ¼ of pills were taken!
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“Ideal” Number of Pills
PM PM
SLNB
LC LIH I
H
Ideal # pills 5 10 15 15 1
5
Calculated for each case by determining the number of pills that
would fulfill the opioid use of > 80% of the patients
0
5
10
15
20
25
30
35
Pe
rce
nt
Su
rvey
ed
Po
pu
lati
on
Pills Taken
PM PM
SLNB
LC LIH IH
Ideal # pills 5 10 15 15 15
Median # pills actually
prescribed
20 20 30 30 30
57% decrease
84%
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Effect of provider education intervention
➢ We presented opioid use data and these guidelines at Grand Rounds, GS
section meeting, sent emails, resident teaching session April, May 2016
➢ Recommended use acetaminophen and ibuprofen first, then opioids
• What % of pts will have 50% reduction in pain for 6 hours (Cochrane)?
Ibuprofen and acetaminophen: 73% ibuprofen alone: 52% Oxycodone:
23% placebo: 17%
• Ibuprofen and acetaminophen as effective as opioid plus acetaminophen in
RCT ER setting acute pain
➢ Observed opioid prescribing patterns same 5 outpatient operations, June-
September 2016, 224 patients
➢ Collected data on opioid use Derry S. Cochrane Library 2013; 6:DC010289
Derry C. Cochrane Library 2013; 6:DC010210
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Comparison of opioid prescriptions pre vs post provider
education
Mean number of opioid pills
prescribed (SD)
Median number of
opioid pills
prescribed
Range
Operation Pre Post p-value Pre Post Pre Post
PM 19.8 5.1 0.0001 20 5 0-50 0-20
PM SLNB 23.7 9.6 0.0001 20 10 0-60 5-15
LC 35.2 19.4 0.0001 30 15 0-100 0-40
LIH 33.8 19.3 0.0001 30 15 15-70 0-30
IH 33.2 18.3 0.0003 30 15 15-120 0-40
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Effect of education intervention on total number of opioid
pills actually prescribed
53% decrease !
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Were patient’s pain medication needs met?
Of 224 patients,
• Only 34% of the prescribed opioids were taken.
• Only 1 patient (<0.5%) required an opioid refill.
Answer: YES!
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Prescriptions in excess of guidelines
32% of total patients were prescribed more pills than recommended
• 34 providers wrote prescriptions
• 6 attendings, 41% excessive
• 27 residents, 35% excessive
• 4 providers wrote for half of all the excessive prescriptions
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Analgesic use after partial mastectomy
0
10
20
30
40
50
60
70
80
90
100
Partial Mastectomy
% P
ati
en
ts
No Opioid
Acetaminophen or NSAID
Both Acetaminophen and NSAID
Opioid Only
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Analgesic use after Lap CCY
0
10
20
30
40
50
60
70
80
90
100
Laparoscopic Cholecystectomy
% P
ati
en
ts
No Opioid
Acetaminophen or NSAID
Both Acetaminophen andNSAID
Opioid Only
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Conclusions
• An educational intervention resulted in a marked decrease in opioids prescribed for 5 general surgery operations
• Number of pills prescribed decreased by 53%
• All 5 operations showed a statistical decrease in pills prescribed
• Much less variability in number pills prescribed
• Patient pain was not worse: only 1 of 224 patients obtained opioid refill
• 85% of pts used either acetaminophen or NSAID
• Opportunity: only 21% used both acetaminophen and NSAID
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How many opioids should be prescribed to
patients who are discharged after surgery which
requires an inpatient admission?
Laws limiting number of pills
prescribed to a “7 day supply”
Ambiguity:
Is a 7 day supply 21 pills (1 every 6 hrs while awake) or 84 (2 every 4 hrs)?
Do you assume the patients will use less pills every day?
Is 7 days the right number, or 5, or 10?
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Methods
Six common inpatient operations July –Dec, 2016:
Studied 333 patients
Excluded patients chronic opioid use, complications, discharged to
nursing facility
85% sent home with opioid prescription
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Home Opioid Use
90% of patients answered
questionnaire or phone call
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DC on POD =1 DC on POD ≥2
Home opioid useInpatient use on day
prior to discharge
Home opioid use
Analysis Groups
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Home opioid use for patients discharged
on POD 1
0
5
10
15
20
25
30
35
40
45P
erc
ent
Home Opioid Use After Discharge (Pills)
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Univariate and multivariate analysis of factors
associated with home opioid use
We found:
1) The number of pills taken the day prior to
discharge was the best predictor of how many
opioids were used at home
2) Opioid use at home after inpatient admission was
independent of the operation performed
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Variable n Pills taken after
discharge,
Mean, (SD)
Univariate
p value
Multivariate
p value
Age <0.0001 0.006
Less than 60 80 13 (18)
60+ 75 4 (9)
Gender 0.03 0.42
Male 57 8 (17)
Female 98 9 (13)
Surgery type 0.12 0.13
Colectomy 64 5 (10)
Liver 11 7 (10)
Hernia 16 17 (27)
Pancreas 10 6 (7)
Bariatric 40 11 (15)
Foregut 14 12 (14)
Length of stay 0.0004 0.08
2 days 57 13 (18)
3+ days 98 6 (12)
Use of either
Tylenol or
Ibuprofen
0.78 0.74
No 34 11 (22)
Yes 115 8 (12)
Number of pills
taken the day prior
to discharge
<0.0001 <0.0001
0 63 1 (4)
1-3 51 8 (9)
4+ 41 21 (21)
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No opioid pills taken day prior to discharge
0
10
20
30
40
50
60
70
80
90
0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20
Perc
ent
Home Opioid Use After Discharge (Pills)
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1-3 opioid pills taken on day prior to discharge
0
5
10
15
20
25
30
35
40
0 1-5 6-10 11-15 16-20 21-25 26-30
Perc
ent
Home Opioid Use After Discharge (Pills)
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≥ 4 opioid pills taken day prior to discharge
0
5
10
15
20
25
30
35
0 1-10 11-20 21-30 31-40 41-50 51-60 61-70 71-80 80-90 90-100
Perc
ent
Home Opioid Use After Discharge (Pills)
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Prescription guidelines to satisfy 85% of
patients’ home opioid usage
Discharge Date Number to Prescribe
POD =1
POD ≥2
Pills used on
day prior to DC
0 pills
1-3 pills
≥4 pills
15
0
15
30
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Potential Savings in Opioid Pills
Prescribed if our Guidelines were Used
40%
![Page 41: Appropriate Opioid Prescribing for Acute Pain after Surgerylib.adai.washington.edu/ctnlib/PDF/1304.pdf · 2018-02-16 · Appropriate Opioid Prescribing for Acute Pain after Surgery](https://reader033.fdocuments.net/reader033/viewer/2022042811/5fa8cca24996d514b24c54b9/html5/thumbnails/41.jpg)
Guidelines will likely overestimate home
opioid needs
• Use of non-opioid pain medication
only 28% used both acetaminophen and ibuprofen
• Elderly- prescribe less
• Set the bar lower and E-prescribe refills
If set at 65% of pts needs, then decrease # used by 60%
• Opioid use for non-surgical pain indications
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47
18
14
7
7
7
Outliers
40 patients took
more pills than
the
recommended
prescription
amount
53% took
opioids for
reasons other
than surgical
pain
Post-op pain
Sleep
As prescribed
Non-surgical
pain
Indigestion
Fear
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What happens to excess pills?
FDA approved disposal:
• First DH outpatient study: 9%
• Inpatient study 1 year later: 19%
Take Back Days
Buy back programs, Jean Liu, WRJ VA
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Conclusions: Inpatient Prescriptions
• The strongest predictor of home opioid use was
inpatient use the day prior to discharge
• Opioid use at home after inpatient admission was
independent of the operation performed
• Established a guideline for discharge opioid
prescribing easy to use and remember
• Use of this guideline will greatly decrease # opioids
prescribed and will take care of patients’ pain
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