Aplied Nutrition Cancer

8/17/2019 Aplied Nutrition Cancer

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Diet, Nutrition and the

Prevention of Cancer


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∗ Cancers of the Breast, Colon, Prostrate and

Endometrium are strongly correlated withincreased consumption of animal fat.

Dietary Fat and Meat nta!e


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∗ Meta"analysis of case control studies haveshown that increase ris! of #reast cancerwas somewhat greater for saturated andmonounsaturated fats than forpolyunsaturated fats.

Breast Cancer and Fats


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∗ n $outhern European countries, increase

inta!e of monounsaturated fats have arelatively low rates of #reast cancer #ecauseof the high average inta!es of olive oil.

Breast Cancer and Fats


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∗ n the multivariate analysis, red meat inta!e

remained signi%cantly predictive of ris! ofcolon cancer.

Colon Cancer and Fats

∗

& cohort study in owa women also found directassociation with processed meats with coloncancer.


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∗ nta!e of red meat and animal fat has a

positive association with prostrate cancer.

Colon Cancer and Fats


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'ther Cancers and Fats

∗ & prospective study among women showedno evidence of relation #etween fat inta!eand ris! of endometrial cancer.

∗ Positive associations have hypothesi(ed #etween

fat inta!e and ris!s of s!in cancer and lungcancer.


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∗ nverse associations #etween cancers of the

oral cavity, laryn), esophagus, endometrium,cervi), #ladder, !idney and #reast with highinta!e of fruits and vegeta#les.

Fruits and *egeta#les

∗nverse associations with tomato products,the primary source of the carotenoidlycopene, with prostrate cancer


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∗ +igh %#er, low meat consumption, high

physical activity showed low rates of coloncancer.

Dietary %#ers and Cancer

∗

+igher inta!e of %#er has #een found toreduce ris! of #reast cancer.


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∗ +igh consumption of alcohol, in com#ination

with smo!ing, is a well"esta#lished cause ofcancer of oral cavity, laryn), esophagus andliver.

&lcoholic and CaeinatedBeverages and Cancer

∗ +igh consumption of alcohol, in com#ination withsmo!ing, is a well"esta#lished cause of cancer oforal cavity, laryn), esophagus and liver.


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∗ 'ne or two drin!s of alcohol per day increaseris! of #reast cancer.

&lcoholic and CaeinatedBeverages and Cancer

∗ Moderate alcohol consumption appears toassociated with cancers of the colon and

rectum.

∗ Coee consumption has #een unassociatedwith gastric cancer.


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∗ *itamin & supplements at the -D& levelmight #e associated with reductions in#reast cancer incidence.

*itamin $upplements and

Cancer

∗ Folic acid reduce ris! of large #owel cancer.

∗ *itamin E reduced ris! of oral cancer andgastric cancer.


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∗ Men and women who had the highest inta!es

of calcium /011mg a day2 through #oththeir diet and supplement use had amodestly reduced ris! of colorectal cancercompared with those who had the lowest

calcium inta!es.

Calcium and Cancer


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∗ &3ato)in B, induces gene mutations causing

unscheduled DN& synthesis and celltransformation.

Carcinogens in Food

∗ $terigmatocystin generated #y thePenicillum, Biopolaris and &spergillus also

induces hepatocellular carcinomas in rats.

∗ 'chrato)in & produced #y &spergilllus andother fungi causes tu#ular cell carcinomas of

the !idney in female rats.


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∗ $hita!e, a popular edi#le mushroom in 4apan

contains agaritine, false morel whichcontains hydra(ine derivatives inducemalignant histiocytomas and liver cellcarcinomas in hamsters.

Carcinogens in Food


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∗ $afrole, a ma5or constituent of the oil of the sassafrastree and has #een used as fragrance in soft drin!s and

soaps induce hepatomas and angiosarcomas in mice..

Carcinogens in Food

∗ Nitrosamines containing food such as coo!ed #acon,and the #eer has increased the ris! of colon cancer.


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∗ Polycyclic aromatic hydrocar#ons produced #yheating materials are widely distri#uted in our

environment. Broiled stea! is reported to #econtaminated #y these various su#stances.

Carcinogens in Food

∗ E)cess sodium chloride has #een lin!ed togastric cancer.

Aplied Nutrition Cancer

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