AP BIOLOGY REVIEW SESSION 4. Regulatory gene Promoter DNA Gene 1 Operator A typical operon Gene 2...
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Transcript of AP BIOLOGY REVIEW SESSION 4. Regulatory gene Promoter DNA Gene 1 Operator A typical operon Gene 2...
Regulatorygene Promoter
DNA
Gene 1Operator
A typical operon
Gene 2Gene 3
Encodes repressorthat in active formattaches to operator
RNApolymerasebinding site
Switches operonon or off
Nucleus fromdonor cell
Early embryoresulting fromnuclear trans-plantation
Surrogatemother
Cloneof donor
Nucleus fromdonor cell
Early embryoresulting fromnuclear trans-plantation
Embryonicstem cellsin culture
Specializedcells
Generegulation
(a)prokaryoticgenes oftengrouped into
in eukaryotesmay involve when
abnormalmay lead to
can produce
is a normal gene thatcan be mutated to an
oncogene
can cause
(c)
(g)(f)
multiple mRNAsper genetranscription
femalemammals
(e)
(d)
(b)
operons
areswitchedon/off by
in activeform binds to
controlled byprotein called
occurs in are proteinsthat promote
1.EXPLAIN HOW PROKARYOTIC GENE CONTROL OCCURS IN THE OPERON
2.DESCRIBE THE CONTROL POINTS IN EXPRESSION OF A EUKARYOTIC GENE
3.DESCRIBE DNA PACKING AND EXPLAIN HOW IT IS RELATED TO GENE EXPRESSION
4.EXPLAIN HOW ALTERNATIVE RNA SPLICING AND MICRORNAS AFFECT GENE EXPRESSION
5.COMPARE AND CONTRAST THE CONTROL MECHANISMS FOR PROKARYOTIC AND EUKARYOTIC GENES
YOU SHOULD NOW BE ABLE TO
Copyright © 2009 Pearson Education, Inc.
6.DISTINGUISH BETWEEN TERMS IN THE FOLLOWING GROUPS: PROMOTER—OPERATOR; ONCOGENE—TUMOR SUPPRESSOR GENE; REPRODUCTIVE CLONING— THERAPEUTIC CLONING
7.DEFINE THE FOLLOWING TERMS: BARR BODY, CARCINOGEN, DNA MICROARRAY, HOMEOTIC GENE; STEM CELL; X-CHROMOSOME INACTIVATION
8.DESCRIBE THE PROCESS OF SIGNAL TRANSDUCTION, EXPLAIN HOW IT RELATES TO YEAST MATING, AND EXPLAIN HOW IT IS DISRUPTED IN CANCER DEVELOPMENT
YOU SHOULD NOW BE ABLE TO
Copyright © 2009 Pearson Education, Inc.
9. EXPLAIN HOW CASCADES OF GENE EXPRESSION AFFECT DEVELOPMENT
10.COMPARE AND CONTRAST TECHNIQUES OF PLANT AND ANIMAL CLONING
11.DESCRIBE THE TYPES OF MUTATIONS THAT CAN LEAD TO CANCER
12.IDENTIFY LIFESTYLE CHOICES THAT CAN REDUCE CANCER RISK
YOU SHOULD NOW BE ABLE TO
Copyright © 2009 Pearson Education, Inc.
Bacterialclone
DNAfragments
Cut Bacterium
Recombinantbacteria
Genomic library
RecombinantDNA
plasmids
Cut
Plasmids
Longer fragmentsmove slower
Powersource
Shorter fragmentsmove faster
Mixture of DNA fragments
A “band” is acollection of DNAfragments of oneparticular length
DNA attracted to +pole due to PO4
– groups
Bacterialplasmids
(a)
(b)
are copied via
treated with
DNAamplified
via
treated with
DNAsample
(c)
DNAfragments
sorted by size via
Recombinant plasmidsare insertedinto bacteria
Add
(d)
ParticularDNA
sequencehighlighted
(e)
Collectionis called a
(f)
are copied via
(c)
DNAfragments
sorted by size via
Recombinant plasmidsare insertedinto bacteria
Add
(d)
ParticularDNA
sequencehighlighted
(e)
Collectionis called a
(f)
(b)
1.DISTINGUISH BETWEEN TERMS IN THE FOLLOWING GROUPS: RESTRICTION ENZYME—DNA LIGASE; GM ORGANISM—TRANSGENIC ORGANISM; SNP—RFLP; GENOMICS—PROTEOMICS
2.DEFINE THE FOLLOWING TERMS: CDNA, GEL ELECTROPHORESIS, GENE CLONING, GENOMIC LIBRARY, “PHARM” ANIMAL, PLASMID, PROBE, RECOMBINANT DNA, REPETITIVE DNA, REVERSE TRANSCRIPTASE, STR, TAQ POLYMERASE, VECTOR, WHOLE-GENOME SHOTGUN METHOD
3.DESCRIBE HOW GENES ARE CLONED
YOU SHOULD NOW BE ABLE TO
Copyright © 2009 Pearson Education, Inc.
4.DESCRIBE HOW A PROBE IS USED TO IDENTIFY A GENE OF INTEREST
5.DESCRIBE HOW GENE THERAPY HAS BEEN ATTEMPTED AND IDENTIFY CHALLENGES TO THE EFFECTIVENESS OF THIS TREATMENT APPROACH
6.DISTINGUISH BETWEEN THE USE OF PROKARYOTIC AND EUKARYOTIC CELLS IN PRODUCING RECOMBINANT DNA PRODUCTS
7.IDENTIFY ADVANTAGES TO PRODUCING PHARMACEUTICALS WITH RECOMBINANT DNA TECHNOLOGY
YOU SHOULD NOW BE ABLE TO
Copyright © 2009 Pearson Education, Inc.
• WHAT IS THE PROCESS BY WHICH GENOTYPE BECOMES EXPRESSED AS PHENOTYPE?
• A. GENE EXPRESSION
• B. PHENOGENESIS
• C. TRANSCRIPTION
• D. RECOMBINATION
ANSWER
• TO INITIATE TRANSCRIPTION, RNA POLYMERASE BINDS TO A(N) _______.
• A. OPERATOR
• B. EXON
• C. PROMOTER
• D. REGULATORY GENE
ANSWER
• GENETICALLY IDENTICAL ORGANISMS ARE CALLED __________________.
• A. OPERONS
• B. CLONES
• C. MICROARRAYS
• D. HOMEOTICS
ANSWER
• CANCER-CAUSING GENES ARE CALLED ________________.
• A. PATHOGENES
• B. ONCOGENES
• C. HOMEOTIC GENES
• D. CANCOGENES
ANSWER
• WHAT SUBSTANCE IS KNOWN TO CAUSE MORE CASES AND TYPES OF CANCER THAN ANY OTHER?
• A. ALCOHOL
• B. FOOD COLORING
• C. TOBACCO
• D. CAFFEINE
ANSWER
• WHAT IS RECOMBINANT DNA?
• A. DNA THAT IS PRODUCED AS A RESULT OF CROSSING OVER
• B. DNA THAT CARRIES GENES FROM DIFFERENT ORGANISMS
• C. DNA THAT CARRIES ONCOGENES
• D. AN ALTERNATE FORM OF DNA THAT IS THE PRODUCT OF MUTATION
ANSWER
• HOW DOES A VACCINE WORK?
• A. IT INHIBITS BACTERIAL REPRODUCTION
• B. IT KILLS CELLS INFECTED WITH A VIRUS
• C. IT PROVIDES TEMPORARY IMMUNITY TO A PATHOGEN
• D. IT STIMULATES THE IMMUNE SYSTEM
ANSWER
• RESTRICTION ENZYMES ARE OBTAINED FROM ______.
• A. ARCHAEA
• B. BACTERIA
• C. EUKARYOTES
• D. RETROVIRUSES
ANSWER
• WHAT NAME IS GIVEN TO A REGION OF DNA THAT IS, WITH THE EXCEPTION OF IDENTICAL TWINS, UNIQUE TO EACH INDIVIDUAL?
• A. GENETIC MARKER
• B. CODON
• C. GENETIC PROBE
• D. RESTRICTION FRAGMENT
ANSWER