ANTIMICROBIAL AGENTS ANDCHEMOTHERAPY

VOLUME 18 * NUMBER 6 0 DECEMBER 1980

EDITORIAL BOARDLEON H. SCHMIDT, Editor-in-Chief (1985)

University ofAlabama in Birmingham,Birmingham, Alabama

HERBERT L. ENNIS, Editor (1982)Roche Institute ofMolecular Biology,

Nutley, New JerseyJOEL G. FLAKS, Editor (1981)

University ofPennsylvania, Philadelphia

ROBERT L. HAMILL, Editor (1985)Eli Lilly & Company, Inc.Indianapolis, Indiana

EDWARD W. HOOK, Editor (1981)University of Virginia, Charlottesville

GEORGE A. JACOBY, JR., Editor (1985)Massachusetts Geyneral Hospital

Boston, Massachusetts

Vincent T. Andriole (1981)John P. Anhalt (1981)Donald Armstrong (1980)Robert Austrian (1980)Arthur L Barry (1980)John E. Bennett (1981)Lawrence E. Bryan (1982)Robert E. Brummitt (1982)D. Buyske (1980)Yves Chabbert (1980)Royston C. Clowes (1980)C. Glenn Cobbs (1980)Paul S. Cohen (1980)Naomi Datta (1981)Julian Davies (1980)Lawrence E. Day (1980)R. Gordon Douglas, Jr. (1980)Theodore Eickhoff (1982)Arthur English (1980)David S. Feingold (1981)Robert Fekety (1981)Sydney Finegold (1982)Robert J. Fitzgerald (1980)Anthony J. Glazko (1981)frring H. Goldberg (1982)Harry Gooder (1982)Jack Gwaltney (1980)Maurice W. Harmon (1981)-Michael Hig n (1980)Ronald D. Hinsdill (1982)Richard Hornick (1980)L. H. Huang (1982)Milton Huppert (1980)

George Gee Jackson (1980)Thomas Jones (1980)William J. Jusko (1980)Donald Kaye (1982)Jerome 0. Klein (1982)Vernon Knight (1980)George S. Kobayashi (1982)Jordan Konisky (1980)Matthew E. Levison (1981)Friedrich C. Luft (1981)Joan Lusk (1980)R. Luthy (1980)Gerald L Mandell (1980)Gerald Medoff (1980)Barbara Minshew (1982)S. Mitsuhashi (1980)Robert C. Moellering, Jr. (1982)R. B. Morin (1982)Bernard Moss (1981)John D. Nelson (1980)Harold C. Neu (1980)J. F. Niblack (1980)T. J. Perun (1980)Charles A. Plate (1982)Burton M. Pogeli (1981)K. E. Price (1982)Paul Quie (1980)W. H. G. Richards (1980)Mark H. Richmond (1982)R. W. Rickards (1980)Richard Roberts (1982)Ian M. Rollo (1982)Richard Root (1980)

Jon E. Rosenblatt (1982)Milton R. J. Salton (1981)Merle Sande (1982)Jay Sanford (1980)Arthur K. Saz (1982)F. C. Sciavolino (1982)Oldrich K. Sebek (1980)William M. Shannon (1980)Jerome J. Schentag (1982)John C. Sherris (1980)Charles Shipman, Jr. (1982)Robert W. Sidwell (1981)Walter Siegenthaler (1980)Sigmund S. Socransky (1980)P. Frederick Sparling (1981)R. Sutherland (1982)Vera L. Sutter (1981)Morton N. SwartzL(1982)Richard-B. Sykes (1982)Alexander Tomasz (1982)Ralph Tompsett (1982)-Hamao Umezawa (1981)Donald Van Harken (1982)D. Vazquez (1980)Michael Waring (1981)John Washington 1 (1981)Pamela Waterworth (1982)Jerry A. Weisbach (1982)B. Weisblum (1982)Peter G. Welling (1982)Richard Wenzel (1980)

Giseila Poflock, Acting Managing EditorEleanor Tupper, Production Editor1913 I St., NW, Washington, DC 20006

EX OFFICIOAlbert Balows, President (1980-1981)

J. Mehsen Joseph, SecretaryAntimicrobial Agents and Chemotherapy (ISSN 0066-

4804), an interdisciplinary publication ofthe American Societyfor Microbiology, 1913 I St., NW, Washington, DC 20006, isdevoted to the dissemination of knowledge relating to allaspects of antimicrobial agents, anticancer agents, and chemo-therapy. Instructions to Authors are published in the Januaryissue each year. Antimicrobial Agents and Chemotherapy ispublished monthly, and the twelve numbers are divided intotwo volumes per year. The nonmember subscription price is$65 per year. The member subscription price is $16 per year.Single copies are $6. Correspondence relating to subscriptions,reprints, defective copies, availability of back issues, lost orlate proofs, disposition of submitted manuscripts, and generaleditorial matters should be directed to the ASM PublicationsOffice, 1913 I St., NW, Washington, DC 20006 (area 202 833-9680).El*:{¢Xs i qVo

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Second clas postage paid at Washington, DC 20006, and atadditional mailing offices.Made in the United States of America.Copyright C) 1980, American Society for Microbiology.All Rights Reserved.The code at the top of the first page of an article in this

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Author IndexAbe, Hiromu, 980Andrews, Jenny M., 844Angehrn, Peter, 913Atherton, Frank R., 897

Baker, John S., 872Barriere, Steven L., 952Bekki, Eiichi, 980Bergstrom, Donald E., 957Bodey, Gerald P., 939Bolton, W. Kline, 933Bowie, W. R., 978Broughall, John M., 844Bywater, Martin J., 844

Cheng, Yung-chi, 957Cherubin, Charles E., 893Cohn, John R., 872Conte, John E., Jr., 952Corrado, Michael L., 893Courtney, Mary-Anne, 926

Dabernat, Henry J., 841De Grandis, S., 948Delmas, Catherine F., 841

Fass, Robert J., 906Field, A. Kirk, 929Fleming, P. C., 948

Gambertoglio, John, G., 952Geraci, Joseph E., 944Gitelman, J., 962Grill, Susan, 957

Hall, Michael J., 897Harris, Patricia C., 922Hashimoto, Ikuo, 980Hassall, Cedric H., 897Hilleman, Maurice R., 929

Hirasawa, Sadako, 980Holmes, Simon W., 897Holt, Alan, 844Hopke, Charles J., 929Hurley, David J., 969

Inbar, M., 962Inoue, Matsuhisa, 853Isaacs, Linda L., 983

Jungkind, Donald L., 872

Karmali, M. A., 948Kohn, A., 962Krontz, Daniel P., 882

Lambert, Robert W., 897Landesman, Sheldon H., 893Lareng, Marie B., 841Lin, Emil T., 952Lloyd, William J., 897Logan, Margaret N., 844Luft, Friedrich C., 983

Matsumoto, Joseph Y., 944Melo, Julio, 926Mikami, Jiroh, 980Miller, James R., 926Minami, Shinzaburo, 853Mitsuhashi, Susumu, 853Mutimer, Malcolm D., 976

Nakamura, Takashi, 980

Overby, Terry L., 933

Panwalker, Anand P., 877Pelzer, Helmut, 887Penner, J. L., 868

Piepersberg, Wolfgang, 863Porembski, Priscilla E., 877Preston, M. A., 868Probst, Peter J., 913

Raff, Martin J., 926Rankin, Laura I., 983Reeves, David S., 844Reiner, Roland, 913Reuter, Wolfgang, 887Ringrose, Peter S., 897Ruth, Jerry, 957

Sande, Merle A., 933Sawada, Yasuo, 980Scattergood, Edgar M., 929Sealey, Lynn B., 922Sheld, W. MichaeL 933Spyker, Daniel A., 933Stocklein, Walter, 863Strausbaugh, Larry J., 882Streips, Uldis N., 926Summersgill, James, 926

Tainturier, Daniel J., 841Then, Rudolf L., 913Trager, Gary M., 877Tytell, Alfred A., 929

Waisbren, Burton A., 969Waisbren, Steven J., 969Washington, John A., II, 944Watanabe, Yasuo, 980Weaver, Susanne S., 939Werner, Rolf G., 858Wilson, Walter R., 944Wise, Richard, 844Woolcock, John B., 976Wright, Alan J., 944

Yum, Moo N., 983

ANNOUNCING

THIRD INTERNATIONAL SYMPOSIUMON

RAPID METHODS AND AUTOMATIONIN MICROBIOLOGY*

26-30 MAY 1981WASHINGTON, D.C.

TOPICAL AREAS WILL INCLUDE

* clinical, medical, and public health microbiology* industrial microbiology* environmental microbiology* food microbiology* quality control* microbiological technology in developing nations

SHORT PAPERS ARE INVITED AND MUST BESUBMITTED ON OFFICIAL ABSTRACT FORMSBY 31 DECEMBER 1980 to ASM HEADQUARTERS,1913 "EYE" ST., WASHINGTON, D.C. 20006.

For further information write:

Dr. Richard C. Tilton, ChairmanISRMA Planning CommitteeUniversity of Connecticut Health CenterDepartment of Laboratory Medicine263 Farmington AvenueFarmington, Connecticut 06032

* Sponsored by the American Society for Microbiology

ACKNOWLEDGMENT

The Editors express their thanks to the following individuals who so kindly refereed the papers

submitted for publication during the past year.

Fred R. AllisonGordon ArcherGeorge R. AronoffRichard H. BaltzR. M. BannatyneM. BarzaJoseph H. BatesHarry N. BeatyGerald P. BodeyW. Kline BoltonT. R. BreitmanCharles S. BryanG. BryceWard E. BullockJoseph H. BurchenalEnrico CabibCharles C. J. CarpenterRoy Cleeland, Jr.D. B. ClewellKenneth W. CochranRoger M. ColeRita R. ColwellBarry S. CoopermanRobert B. CouchJack CrawfordJames CurtinL. Daneo-MoorePatrick J. DavisFloyd DennyW. E. DismukesGerald DonowitzRichard DumaDavid DurackGertrude B. ElionR. EstabrookW. Edmund Farrar, Jr.Martin ForbesCarl J. FriedmanY. FuruichiL. P. GangarosaW. Lance GeorgeDale N. GerdingHoward Goldfine

Robert C. GoodSherwood L. GorbachD. P. GriswoldRichard L. GuerrantLawrence S. GuymonWendell H. HallRobert E. W. HancockWilliam L. HansonJean E. HawkinsJoseph E. HawkinsDavid K. HendersonJ. Owen HendleyPaul D. HoeprichKing K. HolmesEdward W. Hook IIIRobert N. HullL. 0. IngramKeith JensenWarren D. Johnson, Jr.G. KaczorowskiS. KerwarArlyn KinkelNancy KlecknerJ. KnowlesOksana KoreniowskiGeorge P. KubicaCalvin M. KuninS. A. LernerStuart B. LevyCharles E. McCallA. A. MedeirosL. Bruce MellettLouis H. MillerDavid MontgomerieHiroshi NikaidoT. NorthRichard D. PearsonW. PlunkettD. A. PrestonJames RaleighW. B. RedmondMichael F. ReinJ. Robinson

Rial D. RolfeJohn P. RosazzaH. RozenkrantzLeon D. SabathD. S. SalsburgW. E. SandersSam SchefflerMichael ScheldR. A. ScudamoreG. D. ShockmanT. F. SmithWallace SnipesB. G. SprattDaniel A. SpykerVilma StanisichE. 0. StapleyRolf SternglanzGene StollermanJ. StromingerEverett SugarbakerR. L. SwitzerF. P. TallyC. ThornsberryD. J. TipperMarvin TurckB. TylerPaul UnderwoodJ. UnowskyL. WannamakerLawrence G. WayneL. WeinsteinHerbert WeissbachArthur C. WhiteL. J. WilkoffR. WilliamsonD. S. WilsonCarl L. WinelySheldon M. WolffEmanuel WolinskyMartha YowPauline K. W. YuThomas Zimmerman

987

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D 4. .. Actign Managin0 Editonr- (w 197 P) (Sec wtnirions .-. ret)

AUTHOR INDEX

VOLUME 18

Abe, Hiromu, 980Adachi, Kimiko, 513Agee, C. Coe, 243Agyare, Emmanuel O., 832Ahmad, M. H., 798Akiyama, Shin-ichi, 226Alestig, Kjell, 349Amatnieks, Yuri E., 101Andrews, Jenny M., 844Angehrn, Peter, 913Anne, Jozef, 231Apollo, Elaine, 784Arai, Susumu, 1Arango, Maria D., 190Arnaud, J. P., 69Arnett, Gussie, 598Aronoff, George R., 212Atherton, Frank R., 897Atkinson, Barbara, 807

Badal, R. E., 338Badal, Robert E., 773Badaracco, Gianfranco, 50Baker, C. N., 338Baker, Carolyn N., 773Baker, John S., 872Baker, S., 369Baldwin, Jack E., 465Balt, Sijbe, 249Barriere, Steven L., 952Barry, A. L., 338, 716Barry, Arthur L., 88, 487, 616,

773Barton, Nancy H., 709Behar, Caren F., 722Bekesi, J. George, 622Bekki, Eiichi, 980Bennett, Peter M., 200Bennett, William M., 346Bergstrom, Donald E., 957Biron, Karen K., 443Block, Colin S., 493Blomster, Ralph N., 171Bock, August, 798Bodey, Gerald P., 574, 939Bollinger, Mitzi, 474Bolton, L., 137Bolton, W. Kline, 933Bongaerts, Ger P. A., 680Bowie, W. R., 978Braitburg, Janina, 586, 593Brogard, J. M., 69Brook, Itzhak, 164Broughall, John M., 844Bruggeman-Ogle, Kristiane M.,

680Brunken, Jan M., 474Bryan, L. E., 390

Buchanan, Robert A., 709Burd, John F., 264Burdett, Vickers, 753Burgess, Keith R., 829Butzler, J. P., 118Bywater, Martin J., 844

Calhoun, Leslie, 164Came, Paul E., 738Caplan, Ellis S., 448Carp, R. I., 276Carrizosa, J., 564Casero, Robert A., Jr., 317Cassel, Robert, 493Chai, Toby C., 638Chai, Tuu-jyi, 638Chapman, Stanley W., 699Chen, Ming S., 433Cheng, Yung-chi, 957Cherne, John E., 210Cherubin, Charles E., 893Childs, George E., 317Chrystal, Ewan J. T., 568Clavel, Sabine, 357Clement, Frangoise, 357Cobbs, C. Glenn, 709Cohen, Seymour S., 598Cohn, John R., 872Coignau, H., 118Comber, K. R., 182Contacos, Peter G., 289Conte, John E., Jr., 952Coppens, L., 437Corrado, Michael L., 893Courtney, Mary-Anne, 926Coyle, Marie, 814Crowlesmith, Ian, 667, 675Crum, John W., 360Crutzen, Ans Q. H., 521

Dabernat, Henry J., 841Daniel, Muthiah D., 622Dann, Otto, 231David, Hugo L., 357Davis, Henry T., 699de Bolster, Martinus W. G., 249De Clercq, Erik, 231De Grandis, S., 948Delmas, Catherine F., 841Demain, Arnold L., 465Desjardins, Robert E., 317Dessens-Kroon, M., 789Dick, J. D., 158Dickson, Edward T., 27Dierickx, R., 118Diethelm, Arnold G., 709Dobek, Arthur S., 27

Dobeli, H., 111Dobson, Richard A., 738Dornbusch, Kathrine, 220Dorner, M., 69Dougherty, Thomas J., 730Douglas, R. Gordon, Jr., 538Dowell, V. R., Jr., 13Duangmani, Chiraphun, 360

Eda, Yasuko, 37Edberg, Stephen C., 722Edelstein, Paul H., 403Elberg, Svetlana, 586, 593Elion, Gertrude B., 443, 741Elm, Joe L., Jr., 125Engelhardt, J. A., 243Evans, Richard T., 9Eyssen, Hendrik, 231

Falk, Lawrence A., 622Fass, Robert J., 483, 906Fayolle, Fransoise, 504Felsenfeld, Ambhan D., 142Field, A. Kirk, 929Finegold, Carolynn, 586Fique, Dorothy V., 171Fleischaker, Robert J., 130Fleming, P. C., 948Foleno, B., 137Forster, Dieter, 81Fortner, Clarence L., 299Frere, Jean-Marie, 508Fu, Kwung P., 311, 582Fuchs, Peter C., 88Furman, Phillip A., 741

Gabridge, M. G., 243Gambertoglio, John G., 952Garcia, Juan M., 215Gatmaitan, Bienvenido G., 409Gavan, Thomas L., 88Genco, Robert J., 9Georgopapadakou, Nafsika H.,

148, 834Geraci, Joseph E., 944Gerlach, E. H., 716Gerlach, E. Hugh, 88, 616Gerone, Peter J., 142Ghuysen, Jean-Marie, 508Giard, Donald J., 130Gibson, Susan, 142Gilbert, David N., 346Gillett, A. P., 240Ginelli, Enrico, 50Girolami, Roland L., 766Gitelman, J., 962Goldman, Peter, 568

ANTIMICROB. AGENTS CHEMOTHER.

Goldstein, Alma, 761Goldstein, Ellie J. C., 832Gombert, Myles E., 832Gorbach, Sherwood L., 167, 642Gordon, Leon L., 176Gordts, B., 118Goto, Mitsuyoshi, 372Grill, Susan, 957Grinsted, John, 200Groman, Neal, 814Grossberg, Sidney E., 20

Hakenbeck, Regine, 629Hall, Michael J., 897Halstead, Scott B., 125Haltiner, Rita C., 365Hamilton, Bruce K., 454Hamparian, Vincent V., 269Harawawa, Ry6, 58Hardisson, Carlos, 215Hardy, D. J., 544Harris, Patricia C., 922Harvey, Robert J., 323Hashimoto, Ikuo, 980Hassall, Cedric H., 897Hatheway, Charles L., 13Hayden, Frederick G., 538Herbert, Pamela, 355Hewitt, William L., 645Hilleman, Maurice R., 929Hindler, Janet A., 645Hinkle, Anne M., 574Hirasawa, Sadako, 980Hirose, Toshiharu, 377Hirtz, Jean L., 656Holland, James S., 622Holley, H. Preston, 448Holmes, Simon W., 897Holt, Alan, 844Hopke, Charles J., 929Horadam, Victor W., 559Hottendorf, G. H., 176, 746Houghton, Donald C., 346Howe, T. G. B., 667, 675Hughes, John H., 269Humbert, Guy, 656Hurley, David J., 969

Inbar, M., 962Inoue, M., 837Inoue, Matsuhisa, 77, 382, 687,

853Irie, Kenji, 37Isaacs, Linda L., 983Ishizaki, Takashi, 372Iwahi, Tomoyuki, 257Iwai, Yuzuru, 691Izawa, Akio, 37, 41, 45

Jacks, Thomas M., 397Jacobus, Nilda V., 642Jertborn, Marianne, 349Johnson, Paulette, 761

Jones, Benjamin V., 416Jones, R. N., 338, 716Jones, Ronald N., 88, 487, 616,

773J0rgensen, Sigrid Tue, 200Judith, Frederick R., 397Jungkind, Donald L., 872

Kabat, William J., 122Kailasam, S., 661Kampf, Dieter, 81Kaneko, Masae, 226Karmali, M. A., 948Kawahara, Kazuo, 45Kaye, D., 564Kim, H., 780Kim, K. S., 276King, Anna, 292King, Norval W., 622Kinkel, Arlyn W., 709Kisaki, Yoko, 37Kitao, Chiaki, 691Klastersky, J., 437Klayman, Daniel L., 27, 317Klein, Daniel, 508Kleit, Stuart A., 212Kobasa, W. D., 564Kobayashi, George S., 586, 593Koch, Arthur L., 323Koch, Ronald L., 568Koff, Wayne C., 125Kohn, A., 962Koller, Antje E., 730Komatsu, Toshiaki, 37, 41, 45Komiyama, Sohtaro, 226Kondo, Takao, 513Koornhof, Hendrik J., 493Kopferschmitt, J., 69Krontz, Daniel P., 882Kundsin, Ruth B., 738Kurashige, S., 105Kuroda, Kyoichi, 386Kurtz, Terrance O., 645Kuwano, Michihiko, 226

Lambert, Robert W., 897Landesman, Sheldon H., 893Lareng, Marie B., 841Lavillaureix, J., 69Lecaillon, Jean B., 656Lee, Francis H., 746Legeai, R. J., 544Lerman, Stephen J., 474Lerner, A. Martin, 409Levy, Hilton B., 409Lietman, Paul S., 534Lin, C., 780Lin, Emil T., 952Lipsky, James J., 534Liu, Fung Y., 148, 834Livingston, R., 240, 369Llaneza, Juan, 215Lloyd, William J., 897Lobbins, Phyllis M., 9

Logan, Margaret N., 844Lorian, Victor, 807Lubbers, Carol M., 741Luft, Friedrich C., 983Lysko, Paul G., 281, 416

Mandel, Laura J., 722Marcus, Edwin L.; 212Markowitz, Sheldon M., 651Marks, Melvin I., 579Marlin, Graham E., 829Martin, Jerry R., 761Martin, William J., 645Masuyoshi, Shinji, 1Matsubara, Nobuyuki, 195Matsuhashi, Michio, 195Matsumoto, Joseph Y., 944Matsuura, Masayuki, 687Mayhall, C. Glen, 784McCracken, George H., Jr., 476McCroskey, Loretta M., 13McDonough, P., 480McGuffin, Robert W., 471McGuire, Jeffrey C., 454McLafferty, Martha A., 568Means, B., 137Medoff, Gerald, 586, 593Mehl, J. Kurt, 269Meisel, Steven, 206Melo, Julio, 926Menday, A. P., 437Mendez, Francisco J., 215Mendoza, Carmen, 215Merz, W. G., 158Meunier-Carpentier, F., 437Meyer, Richard D., 403Meyers, Joel D., 471Middelbeek, Evert J., 521Migneault, Paula C., 365Mikami, Jiroh, 980Miller, Brinton M., 397Miller, James R., 926Miller, Michael H., 722Minami, Shinzaburo, 77, 195, 382,

853Mitsuhashi, S., 105, 837Mitsuhashi, Susumu, 1, 77, 195,

382, 687, 853Mitsuoka, Tomotari, 58Miyamoto, Masaki, 1Moniz-Pereira, Jose, 357Montgomery, Carol L., 559Moody, Marcia R., 299Morse, Stephen A., 281, 416Mourad, Aly, 696Murakawa, Takeo, 377Murillo, Jorge, 448Mutimer, Malcolm D., 976

Nair, N. G. K., 661Nakagome, Takenari, 37Nakamura, Takashi, 980Nakashita, Einosuke, 386Nakazawa, H., 837

ii AUTHORINDEX

VOL. 18, 1980

Nakazawa, Hisashi, 687Narayana, A. S. L., 661Nauta, Wijbe T., 249Nelson, John D., 476Nelson, Robert L., 212Neu, Harold C., 311, 582Newman, Kathryn A., 299Nishi, Takeshi, 551Nishida, Minoru, 377Nord, Carl Erik, 220North, Thomas W., 598Nuesch, J., 111

O'Callaghan, R. J., 544O'Connor, John R., 738Oden, E., 780Ohkawa, Mitsuo, 386Oill, Phyllis A., 355Oliva, Brunello, 200Olsson-Liljequist, Barbro, 220Omura, Satoshi, 691Orito, Matsuo, 386Ortiz, Jose M., 215Overby, Terry L., 933Owens, Lynn M., 610

Packer, R. R., 338Packer, Richard R., 773Panwalker, Anand P., 877Parker, Richard A., 346Parks, L. W., 822Pass, Robert F., 709Pearson, Richard D., 699Pelzer, Helxnut, 887Penner, J. L., 868Percheson, P. B., 390Pesanti, Edward L., 208Peterson, Lance R., 210Petrucelli, S., 137Phillips, Ian, 292Pieper, John A., 604Piepersberg, Wolfgang, 863Pijper, Pieter J., 249Plevani, Paolo, 50Pohlod, Donald J., 353Porembski, Priscilla E., 877Porter, George A., 346Poulin, Sharon A., 738Preston, M. A., 868Privitera, Gaetano, 504Probst, Peter J., 913Prusoff, William H., 433Pupkoff, Robert, 206

Quinn, Edward L., 353

Raff, Martin J., 926Raghupati Sarma, G., 661Ralph, Edward D., 101Rankin, Laura I., 983Rechenmacher, Angelika, 798Reeves, David S., 844Reiner, Roland, 913

AUTHOR INDEX

Restrepo M.Angela, 190

Reuter, Wolfgang, 887Ringrose, Peter S., 897Roberts, Marilyn C., 610Robertson, Richard G., 365Robinson, Roy G., 493Rodriguez, R. J., 822Rogers, Henry J., 63Rosenblum, Eugene D., 424Ruebush, Trenton K., II, 289Ruth, Jerry, 957

Sakamoto, Hiroshi, 377Sande, Merle A., 933Sanders, William J., 531Sapienza, V. J., 276Saral, R., 158Saravolatz, Louis D., 353Sasahara, Kunihiro, 386Sato, K., 837Saunders, Jean, 493Sawada, Yasuo, 980Sawada, Yosuke, 465Sawaki, Masaru, 386Scattergood, Edgar M., 929Schabel, Frank M., Jr., 598Schachter, Julius, 696Schentag, Jerome J., 604Schiller, John, 814Schimpff, Stephen C., 299Schleim, Klaus-Dieter, 397Schoeller, Jean P., 656Schoenherr, Christine K., 20Schuessler, D., 780Schurig, Randolf, 81Scovill, John P., 27, 317Sealey, Lynn B., 922Sebald, Madeleine, 504Seddon, M., 240Shannon, Kevin, 292Shannon, William M., 598Sheld, W. Michael, 933Shelton, Sharon, 476Shiau, George T., 433Shibata, Sharon A., 355Shimamura, Masayoshi, 386Shin, S., 480Shiota, Faith M., 471Shono, Fumiaki, 45Sibilla, Denise J., 651Simon, Gary L., 167Simons, Ruth, 538Singh, Pushpa D., 465Slots, J0rgen, 9Smilack, Jerry D., 559Smit, Hendrik, 249Smith, Arnold L., 610Smith, Thomas F., 738Smyth, Robert D., 746Snydman, David R., 167Soike, Kenneth F., 142Solomon, Nadine A., 465Somerville, Margaret M., 353

Sommers, Herbert M., 88Sora, Silvio, 50Speedie, Marilyn K., 171Spyker, Daniel A., 933Stamm, John M., 766Standiford, Harold C., 448St. Clair, Marty H., 741Steck, Edgar A., 289Steigbigel, Neal H., 722Steigbigel, Roy T., 699Stewart, George C., 424Stocklein, Walter, 863Stouthamer, Adrian H., 249Strausbaugh, Larry J., 882Streips, Uldis N., 926Stroshane, Ronald M., 454Sugata, Toshiaki, 386Sugg, Nancy, 696Sugimoto, Yoshikazu, 527Sugiyama, Masatoshi, 372Summersgill, James, 926Sutherland, R., 182Suthisomboon, Kalaya, 360Suzuki, Kunio, 58Svaan, John, 206Svedhem, Ake, 349Sweet, Richard L., 696Swenson, Christina D., 610Swenson, Jana M., 13Symchowicz, S., 780Synge, Charlotte, 63Szwed, James J., 212

Tabuki, Toshiko, 226Tadanier, Jack, 761Tainturier, Daniel J., 841Takaoka, Masayoshi, 195TaUy, Francis P., 167, 642Tamulevich, Ruth, 622Tanaka, Haruo, 691Tanaka, Yoshitake, 691Tanayama, Shigeharu, 513Tarpay, Martha M., 579Tatem, Beverly A., 448Taylor, Diane E., 480Taylor, Jerry L., 20Then, Rudolf L., 913Thomas, Monica C., 454Thompson, Philip J., 829Thompson, Stephan G., 264Thornsberry, C., 338, 716Thornsberry, Clyde, 13, 88, 487,616,773

Tight, Robert R., 307Timoney, J. F., 480Toda, M., 837Tomasz, Alexander, 629, 730Toyoshima, Shigeshi, 527Trager, Gary M., 877Tramont, Edmund C., 27Tripathy, S. P., 661Tsuchiya, Kanji, 257, 551Tucker, Bruce C., 709Tytell, Alfred A., 929

* *

iv AUTHOR INDEX

Umeda, Isao, 45

van der Goot, Henderikus, 249van Embden, J. D. A., 789Van Harken, Donald R., 746Vanhoof, R., 118van Klingeren, B., 789van Wijngaarden, L. J., 789Vasiljev, Michael, 746Verheul, Henk, 249Vibulyasekha, Somnuk, 360Vidal, Ronald A., 604Vis, Ronald D., 249Vischer, Wolfgang, 656Vogels, Godfried D., 521

Wade, James C., 299Waisbren, Burton A., 969

Waisbren, Steven J., 969Warren, Christine, 292Washington, John A., II, 944Watanabe, Yasuo, 980Weaver, Susanne S., 939Weihermiiller, Klaus, 81Welch, David F., 579Werner, Rolf G., 858Werringloer, Jurgen, 559Whelchel, John D., 709White, A. R., 182White, Richard J., 454Whitley, Richard J., 709Wiernik, Peter H., 299Williamson, Russell, 629Wilson, Walter R., 944Winston, Drew J., 645Wise, R., 240, 369

ANTIMICROB. AGENTS CHEMOTHER.

Wise, Richard, 844Witiak, Donald T., 269Wolinsky, Emanuel, 531Woods, Vivienne E., 63Woolcock, John B., 976Wright, Alan J., 944

Yasuda, K., 105Yocum, Paula, 164Yogev, Ram, 122Yoshida, Kiyoshi, 513Yoshikawa, Thomas T., 355Yoshitake, Akira, 41, 45Yotsuji, Akira, 382Young, Lowell S., 645Young, Viola Mae, 299Yum, Moo N., 983

Zimmermann, Willy, 94

SUBJECT INDEX

VOLUME 18

Acycloguanosineherpesviruses, 622

Acyclovirgranulocyte progenitor cells, 471varicella-zoster virus, 443

Acyclovir triphosphateinhibition of DNA polymerases, 741

Adenosine triphosphataseinhibition by neomycin, 532

Aeromonas hydrophilacefoperazone, 483

Alafosfalinrelated phosphonopeptide antibacterial agents, 897

D-Alanyl-D-alanineanalogs inhibiting E. coli murein synthesis, 887

Amikacindisk susceptibility test interpretation, 616nephrotoxicity in rat model, 983

8-(L-a-Aminoadipyl)-L-cysteinyl-D-valinecyclization to isopenicillin N, 465

5'-Amino-5'-deoxythymidinediphosphate derivative, 433herpes simplex virus inhibitor, 433synthesis, 433

Aminoglycosidescarbenicillin interactions, in vitro and in vivo, 604combination with newer cephalosporins, 651gram-negative bacilli, 645O-demethylfortimicin A, compared, 773uptake and ribosomal resistance mutations, 798

Amphotericin Bantifungal, K+, Na+, and Mg2" influence, 593ion influence on antifungal activity, 593

Ampicillinresistant H. influenzae surveillance, 474S. aureus susceptibility by Autobac I, 922

Animal modelcarbenicillin-aminoglycoside interactions, 604

Antagonismerythromycin, 872

Antifungal agents15-azasterol, produced by G. flavo-brunneum, 822

Antimicrobial susceptibilitythree Providencia species compared, 868

Antiviral agentsenhanced activity in combination, 536influenza viruses, 536

9-fi-D-Arabinofuranosyladenineenhancement by erythro-9-(2-hydroxy-3-nonyl)-

adenine, 598systemic herpesvirus infections in mice, 598

Autobac IS. aureus susceptibility to penicillin and ampicillin,

92215-Azasterolproduction in G. flavo-brunneum, 822

Bactericidal efficacy

in vitro kinetic model, 377Bacteroides fragilis

tetracycline transport, 502Bile

cefoperazone concentrations, 980

Campylobacter fetus subsp. fetus (intestinalis)cephalosporins susceptibility, 948susceptibility different from C. jejuni, 948

Campylobacterjejunicephalosporins susceptibility, 948susceptibility different from C. fetus subsp. fetus,

948Cantharides-induced blisters

pharmacokineticscefotaxime, 369moxalactam, 369

Carbenicillincefazolin-mecillinam combination, 437interactions with aminoglycosides, in vitro and in

vivo, 604septicemia caused by gram-negative organisms, 437

CefazolinK. pneumoniae DT-S in mice, 549plus mecillinam-carbenicillin, 437S. aureus endocarditis in rabbits, 562

Cefmetazoleimpaired renal function, 386pharmacokinetics in normal humans, 386

CefoperazoneA. hydrophila, 483concentrations in bile and gall bladder wall, 980gram-negative bacilli, 645inoculum effect on P. aeruginosa susceptibility, 893nonfermenters, 483

CeforanideS. aureus endocarditis in rabbits, 562

Cefotaximegram-negative bacilli, 645gram-negative bacilli, pediatrics, 476inoculum effect on P. aeruginosa susceptibility, 893vs. moxalactam

pharmacokinetics, 369tissue levels, 369

CefotiamK pneumoniae DT-S in mice, 549

Cefroxadin (CGP 9000)pharmacokinetics, human, 656

Cephalexinpharmacokinetics, human, 656

Cephalosporin ,-lactamase (cephalosporinase)from E. cloacae, 853

CephalosporinsC. fetus subsp. fetus versus C. jejuni susceptibility,948

newer, S. marcescens susceptibility, 651Cephamycin C

enterotoxigenic colibacillosis, 397

ii SUBJECT INDEX

Cerebrospinal fluidvancomycin penetration in rabbits, 882

Cerumenbactericidal activity, 638

Chlamydia trachomatiserythromycin, relative resistance, 696rosaramicin activity in vitro, 978rosoxacin, 738susceptibility in tissue culture system, 696

Chloramphenicolresistant H. influenzae, characterization, 610

CI-867new semisynthetic penicillin, 939

Clavulanic acidsynergy with piperacillin, 582

Na-Cocoyl-L-arginine ethyl esterhepatitis B surface antigen inactivation, 525

Compound A49759O-demethylfortimicin A, 766, 773

Contagious equine metritisH. equigenitalis susceptibility, 841

Corynebacterium diphtheriaeerythromycin resistance plasmids, 814

Corynebacterium equisusceptibility, 976

Cycloheximideribosomal binding in S. cerevisiae, 863

Daunorubicin glycosidesbiosynthesis, 454e-rhodomycinone, 454

O-Demethylfortimicin Acomparative antimicrobial activity, 766compared with aminoglycosides, 773

3-O-Demethylfortimicinssynthesis, 761

Deoxyribonucleic acid polymerasesinhibition by acyclovir triphosphate, 741

Dibekacinnephrotoxicity in rat model, 983pharmacokinetics, human, 372

Diffusion susceptibility testinterpretive criteria, 487netilmicin, 30-lig disks, 487

Disk susceptibility testsamikacin, interpretive standards, 616moxalactam, interpretive standards, 716Sch 21420, interpretive standards, 616

Eikenella corrodenssusceptibility to newer,8-lactams, 832

Endocarditis, enterococcalprophylaxis, 448

Enterobacter cloacaecephalosporinase, 853,8-Lactamase induction by antibiotics, 382

Enterococcipenicillin/aminoglycoside synergy, 944thymine-thymidine requiring, 365

Enterotoxigenic colibacillosiscephamycin C

calves, 397piglets, 397

Erythro-9-(2-hydroxy-3-nonyl)adenine

ANTIMICROB. AGENTS CHEMOTHER.

combination with araA, 598systemic herpesvirus infections in mice, 598

Erythromycinantagonism to other drugs, 872C. trachomatis resistance, 696resistance plasmids

C. diphtheriae, 814diphtheroids, 814

Erythromycin ethyl succinateeffect of food on absorption, 829

Escherichia colimurein synthesis inhibition, 887

Fatty acidsinactivation of enveloped viruses, 962

Foodeffect on erythromycin ethyl succinate absorption,

829N-Formimidoyl thienamycin

activity vs. fB-lactamase producers, 837crystalline derivative of thienamycin, 557effect of /1-lactamases, 837inoculum effect on P. aeruginosa susceptibility, 893in vitro activity, 557, :642

Fortimicin AO-demethylfortimicin A, comparative activity, 766

Fortimicin Bsynthesis of 3-O-demethylfortimicins, 761

Gall bladdercefoperazone concentrations in wall, 980

Gentamicinnephrotoxicity in rat model, 983prophylaxis against enterococcal enterocarditis, 448synergy with penicillin against enterococci, 944uptake by S. aureus mutants, 722

Geotrichum flavo-brunneumantifungal homoazasterol production, 822growth, 822

Gram-negative bacillicefotaxime, 476cephalosporins, 476moxalactam, 476moxalactam, cefotaxime, cefoperazone, piperacillin,

aminoglycosides, 645pediatric isolates, drug susceptibility, 476Ro 13-9904, 476

Gram-positive bacteriaindolmycin uptake, 858

Granulocyte progenitor cellsacyclovir nontoxicity, 471

Group B streptococcitetracycline-resistant R plasmids, 753

Haemophilus equigenitalissusceptibility, 841

Haemophilus influenzaeampicillin resistance surveillance, 474chloramphenicol resistant, 610plasmid characterization of resistant strains, 610

Hepatitis B surface antigeneffect of NV-cocoyl-L-arginine ethyl ester, 525

Herpes simplex virus

VOL. 18, 1980

E-5-propenyl-2'-deoxyuridine activity, 957Herpesvirus

adenine nucleoside analogs in combination, 598comparative study, interferon and 3 agents, 622

High-pressure liquid chromatographyrosaramicin determination in human serum, 780

Homoazasterolproduction in G. flavo-brunneum, 822

Human albuminmedium for interferon-producing Namalva cells, 929

Human erythrocytespolyene antibiotics, large and small, effects, 586

Human polymorphonuclear leukocyteskilling of oxacillin-exposed S. aureus, 807

Indolmycinuptake in gram-positive bacteria, 858

Influenza virusesdrug combinations, enhanced activity, 536

InterferonNamalva cells in medium with human albumin, 929

Interferon, human lymphoblasticherpesviruses, 622

Isoniazideffect of rifampin and prednisolone on metabolism,

661Isopenicillin Nfrom 8-(L-a-aminoadipyl)-L-cysteinyl-D-valine, 465

Klebsiella pneumoniaebroadening aminoglycoside resistance 542cefazolin, 549cefotiam, 549kanamycin resistance, 542mouse experimental pneumonia, 549R-factor determining multiple resistance, 926

Klebsiella spp.bactericidal kinetics, 877inactivation of,8-lactam drugs, 877susceptibility, 877

fl-Lactam antibioticsbinding to penicillin-binding proteins, 834enzymatic method for quantitation, 506N-formimidoyl thienamycin in vitro, 557, 642inactivtion by Klebsiella spp., 877f,-lactamase induction in E. cloacae, 382mecillinam alone and in combination, 906newer, E. corrodens susceptibility, 832S. pneumoniae penicillin-binding proteins, 629

,f-Lactamasedeficient Rl and RP1 plasmid mutants, 667N-formimidoyl thienamycin

activity against producer, 837effect, 837

from P. rettgeri, purification and properties, 687induction in E. cloacae, 382mecillinam susceptibility of enterobacteria, 680R plasmid mutants, pencillin resistance, 675

Bl-Lactamase inhibitorssynergy with piperacillin, 582

Legionella pneumophilasusceptibility to 20 drugs, 403

SUBJECT INDEX iii

Leucomycineffect of magnesium phosphate on production, 691S. kitasatoensis, 691

Magnesium ionsinfluence on antifungal amphotericin B, 593

Magnesium phosphateleucomycin production by S. kitasatoensis, 691

Mechanism of actionpyocin vs. N. gonorrhoeae, 416

Mecillinamactivity alone and in combination, 906added to carbenicillin-cefazolin, 437enterobacterial susceptibility, 680,f-lactamase and salt effects, 680pharmacokinetics in healthy volunteers, 952

Methicillinresistance transduction to S. aureus, 424S. aureus endocarditis in rabbits, 562

Metronidazolemetabolism and bactericidal activity, 566

Micro-broth dilutionS. pneumoniae susceptibility testing, 579

Minimal bactericidal antibiotic concentrationsS. aureus, reliable determination, 699

Minimal lethal antibiotic concentrationsS. aureus, reliable determination, 699

Minimum inhibitory concentration testingsensititre microtitration trays, 844

Moxalactamdisk susceptibility test interpretive standards, 716gram-negative bacilli, 645gram-negative bacilli, pediatrics, 476inoculum effect on P. aeruginosa susceptibility, 893in patients with renal dysfunction, 933pharmacokinetics, 369tissue levels, 369

Mueller-Hinton agarthymidine-dependent enterococci, 365

Murein synthesisinhibited in E. coli by D-alanyl-D-alanine analogs,

887Mycobacterium marinum

in vitro susceptibility, 529

NafcillinS. aureus endocarditis in rabbits, 562

Namalva cellsgrowth in human albumin medium, 929interferon production in human albumin medium,929

Neisseria gonorrhoeaepenicillinase producing, The Netherlands

epidemiology, 789plasmid characterization, :789

penicillin-binding proteins, 730pyocin inhibition, 416rosoxacin, 738

Neomycininhibition of adenosine triphosphatase, 532

Neonatal infectionsK. pneumoniae, aminoglycoside resistant, 42

Nephrotoxicity

ANTIMICROB. AGENTS CHEMOTHER.

dibekacin compared with gentamicin and amikacin,983

Netilmicindiffusion susceptibility test criteria, 487

Oxacillinkilling of exposed S. aureus by polymorphonuclear

leukocytes, 807

PenicillinBi-lactamase-altered plasmids, resistance, 675S. aureus susceptibility by Autobac I, 922S. pneumoniae, binding components, 390synergy with streptomycin and gentamicin, 944

Penicillin-binding componentsS. pneuhoniae, 390

Penicillin-binding proteinsin susceptible and resistant N. gonorrhoeae, 730,B-lactam antibiotics, interaction in vivo, 629S. aureus, binding of,-lactams, 834S. faecalis, binding of f,-lactams, 834S. pneumoniae, 629

Pharmacokinetics, animalpotassium phosphanilate, 746

Pharmacokinetics, humancefmetazole

impaired renal function, 386normal subjects, 386

cefotaxime, 369cefroxadin (CGP 9000) and cephalexin, 656dibekacin, 372impaired renal function: cefmetazole, 386mecillinam, in healthy volunteers, 952moxalactam, 369potassium phosphanilate, 746vidarabine 5'-monophosphate vs. herpes, 709

Phosphonoacetateherpesviruses, 622

Phosphonoformateherpesviruses, 622

Phosphonopeptide antibacterial agentsrelated to alafosfalin, 897

Pichia kluyverieffect of potassium and sodium ions on toxin, 519killing action in S. cerevisiae, 519

Piperacillincomparative in vitro appraisal, 493gram-negative bacilli, 645inoculum effect on P. aeruginosa susceptibility, 893S. typhi, 493synergy with ,B-lactamase inhibitors, 582

pJT2 plasmiddrug resistance, 480S. typhimurium, 480

Pneumococcal meningitis, experimentaleffect on vancomycin in rabbit cerebrospinal fluid,

882Polyene inhibitors

effect on human erythrocytes, 586large, 586small, 586

Polymorphonuclear leukocyteskilling of oxacillin-exposed S. aureus, 807

Polyriboinosinic-polyribocytidylic acid complex

toxicity modulated by component alterations, 409Potassium ions

influence on antifungal amphotericin B, 593influence on antifungal filipin, 593P. kluyveri toxin, 519

Potassium phosphanilatebioavailability, metabolism in humans and animals,

746Prednisolone

isoniazid metabolism, 661Probenecid

effect on vancomycin in rabbit cerebrospinal fluid,882

E-5-Propenyl-2'-deoxyuridineanti-herpes simplex virus, 957anti-human cell growth, 957

Proteus rettgeri,B-lactamase, purification and properties, 687

Providencia alcalifacienssusceptibility compared with other species, 868

Providencia rettgerisusceptibility compared with other species, 868

Providencia stuartiisusceptibility compared with other species, 868

Pseudomonas aeruginosainoculum effect on susceptibility testing, 893morphology changes under drug synergism, 969

PyocinN. gonorrhoeae inhibition, 416

Renal dysfunctionmoxalactam pharmacokinetics, 933

Resistance plasmidserythromycin

C. diphtheriae, 814diphtheroids, 814

R-factorK. pneumoniae, multiply resistant outbreak, 926

e-Rhodomycinoneconversion to daunorubicin glycosides, 454

Ribosomal resistance mutationsrelated to aminoglycoside uptake, 798

Rifampinisoniazid metabolism, 661

Ro 13-9904gram-negative bacilli, pediatrics, 476in vitro and in vivo studies, 913in vitro evaluation, 574

RosaramicinC. trachomatis activity in vitro, 978detefnination in humans, 780high'pressure liquid chromatography, 780

RosoxacinN. gonorrhoeae, C. trachomatis, U. urealyticum,

738Rl plasmid

fB-ladtamase-deficient mutants, 667penicillin resistance, 675

R plasmidsaltered-fi-lactamase mutants, penicillin resistance,

675,f-lactamase-deficient mutants in E. coli, 667

Saccharomyces cerevisiae

iv SUBJECT INDEX

VOL. 18, 1980

cycloheximide binding to ribosomes, 863P. kluyveri toxin killing action, 519ribosomal binding affinity for cycloheximide, 863

Salmonella typhipiperacillin, 493

Salmonella typhimuriumresistance plasmid pJT2, 480virulent, in calves, 480

Salteffect on enterobacterial mecillinam susceptibility,

680SCE-1365

disposition in rats and dogs, 511Sch 21420

disk susceptibility test interpretation, 616Scourscephamycin C

calves, 397piglets, 397

Selective protection conceptantivirus chemotherapy, 957

Sensititre dried microtitration traysMIC accuracy tested, 844

Septicemiaearly therapy with carbenicillin-cefazolin-mecilli-nam, 437

Serratia marcescenssusceptibility to newer cephalosporins, 651

Sodium ionsinfluence on antifungal amphotericin B, 593P. kluyveri toxin, 519

Staphylococcus aureusampicillin susceptibility by Autobac I, 922Autobac I susceptibility testing, 922drug concentration, effect on tolerance, 784endocarditis

ceforanide, cefazolin, methicillin, nafcillin, 562gentamicin uptake, 722growth phase, effect on drug tolerance, 784killing by polymorphonuclear leukocytes, 807methicillin resistance, transduction, 424penicillin-binding protein binding of fB-lactams, 834penicillin susceptibility by Autobac I, 922

SUBJECT INDEX V

small-colony, aminoglycoside-resistant mutants, 722storage, effect on drug tolerance, 784

Streptococcus faecalispenicillin-binding protein binding of 8l-lactams, 834

Streptococcus pneumoniaemicro-broth dilution susceptibility testing, 579penicillin-binding components, 390penicillin-binding proteins vs. f?-lactams, 629

Streptomyces kitasatoensisleucomycin production, 691

Streptomycinsynergy with penicillin against enterococci, 944

SynergismP. aeruginosa morphology changes, 969

Synergypenicillin/aminoglycosides against enterococci, 944piperacillin plus fi-lactamase inhibitors, 582

Tetracyclineresistance plasmids in group B streptococci, 753transport in B. fragilis, 502

Thymidinedependent enterococci, 365

Toxicitymodified poly(I)-poly(C) complex, 409

Ureaplasma urealyticumrosoxacin, 738

Vancomycinpenetration into rabbit cerebrospinal fluid, 882

Varicella-zoster virusacyclovir, 443

Vidarabine 5'-monophosphatepharmacology, tolerance, antiviral activity in hu-mans, 709

Viruses, envelopedinactivation by essential unsaturated fatty acids, 962

Yeastcycloheximide binding to S. cerevisiae ribosomes,

863

ANTIMICROBIAL AGENTS

AND

CHEMOTHERAPY

VOLUME 18

WASHINGTON, DC 20006

1980

ANTIMICROBIAL AGENTS ANDCHEMOTHERAPY

VOLUME 18 0 1980

EDITORIALLEON H. SCHMIDT, Editor-in-Chief (1985)

University ofAlabama in Birmingham,Birmingham, Alabama

HERBERT L. ENNIS, Editor (1982)Roche Institute ofMolecular Biology,

Nutley, New JerseyJOEL G. FLAKS, Editor (1981)

University of Pennsylvania, Philadelphia

BOARDROBERT L. HAMILL, Editor (1985)

Eli Lilly & Company, Inc.Indianapolis, Indiana

EDWARD W. HOOK, Editor (1981)University of Virginia, Charlottesville

GEORGE A. JACOBY, JR., Editor (1985)Massachusetts General Hospital

Boston, Massachusetts

Vincent T. Andriole (1981)John P. Anhalt (1981)Donald Armstrong (1980)Robert Austrian (1980)Arthur L. Barry (1980)John E. Bennett (1981)Lawrence E. Bryan (1982)Robert E. Brummitt (1982)D. Buyske (1980)Yves Chabbert (1980)Royston C. Clowes (1980)C. Glenn Cobbs (1980)Paul S. Cohen (1980)Naomi Datta (1981)Julian Davies (1980)Lawrence E. Day (1980)R. Gordon Douglas, Jr. (1980)Theodore Eickhoff (1982)Arthur English (1980)David S. Felngold (1981)Robert Fekety (1981)Sydney Finegold (1982)Robert J. Fitzgerald (1980)Anthony J. Glazko (1981)Irving H. Goldberg (1982)Harry Gooder (1982)Jack Gwaltney (1980)Maurice W. Harmon (1981)Michael Higgins (1980)Ronald D. Hinsdill (1982)Richard Hornick (1980)L. H. Huang (1982)Milton Huppert (1980)

George Gee Jackson (1980)Thomas Jones (1980)William J. Jusko (1980)Donald Kaye (1982),Jerome 0. Klein (1982)Vernon Knight (1980)George S. Kobayashi (1982)Jordan Konisky (1980)Matthew E. Levison (1981)Friedrich C. Luft (1981)Joan Lusk (1980)R. Luthy (1980)Gerald L. Mandell (1980)Gerald Medoff (1980)Barbara Minshew (1982)S. Mitsuhashi (1980)Robert C. Moellering, Jr. (1982)R. B. Morin (1982)Bernard Moss (1981)John D. Nelson (1980)Harold C. Neu (1980)J. F. Niblack (1980)T. J. Perun (1980)Charles A. Plate (1982)Burton M. Pogeli (1981)K. E. Price (1982)Paul Quie (1980)W. H. G. Richards (1980)Mark H. Richmond (1982)R. W. Rickards (1980)Richard Roberts (1982)Ian M. Rollo (1982)Richard Root (1980)

Jon E. Rosenblatt (1982)Milton R. J. Salton (1981)Merle Sande (1982)Jay Sanford (1980)Arthur K. Saz (1982)F. C. Sciavolino (1982)Oldrich K. Sebek (1980)William M. Shannon (1980)Jerome J. Schentag (1982)John C. Sherris (1980)Charles Shipman, Jr. (1982)Robert W. Sidwell (1981)Walter Siegenthaler (1980)Sigmund S. Socransky (1980)P. Frederick Sparling (1981)R. Sutherland (1982)Vera L Sutter (1981)Morton N. Swartz (1982)Richard B. Sykes (1982)Alexander Tomasz (1982)Ralph Tompsett (1982)Hamao Umezawa (1981)Donald Van Harken (1982)D. Vazquez (1980)Michael Waring (1981)John Washington I (1981)Pamela Waterworth (1982)Jerry A. Weisbach (1982)B. Weisblum (1982)Peter G. Welling (1982)Richard Wenzel (1980)

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EX OFFICIOAlbert Balows, President (1980-1981)

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Volume 18 Contents for July Number 1

Biosynthesis; Chemistry; Mechanisms of Action and Resistance

High-Yield Interferon Induction by 10-Carboxymethyl-9-Acridanonein Mice and Hamsters. JERRY L. TAYLOR, CHRISTINE K.SCHOENHERR, AND SIDNEY E. GROSSBERG* .. .... 20-26

Effect and Mechanism of Action of Aphidicolin on Yeast Deoxyri-bonucleic Acid Polymerases. PAOLO PLEVANI,* GIANFRANCOBADARACCO, ENRICO GINELLI, AND SILVIO SORA ............ 50-57

Streptococcus faecium-Derived Antibacterial Substance Antagonis-tic to Bifidobacteria. RYO HARASAWA,* KUNIO SUZUKI, ANDTOMOTARI MITSUOKA ..................................... 58-62

Antibacterial Effect of Scandium and Indium Complexes of Entero-chelin on Klebsiella pneumoniae. HENRY J. ROGERS,* CHAR-LOTTE SYNGE, AND VIVIENNE E. WOODS..................... 63-68

Purification and Properties of Cephalosporinase in Escherichiacoli. SHINZABURO MINAMI, MATSUHISA INOUE, AND SUSUMUMITSUHASHI * ............................................ 77-80

Penetration of fB-Lactam Antibiotics into Their Target Enzymes inPseudomonas aeruginosa: Comparison of a Highly SensitiveMutant with Its Parent Strain. WILLY ZIMMERMANN ....... 94-100

Cefroxadine (CGP-9000), an Orally Active Cephalosporin. K. YA-SUDA, S. KURASHIGE, AND S. MITSUHASHI* ....... ..... 105-110

Regulatory Properties of O-Acetyl-L-Serine Sulfhydrylase of Ceph-alosporium acremonium: Evidence of an Isoenzyme and ItsImportance in Cephalosporin C Biosynthesis. H. DOBELI ANDJ. NUESCH* .............................................. 111-117

Examination of Parameters Affecting Human Interferon Productionwith Microcarrier-Grown Fibroblast Cells. DONALD J. GIARD*AND ROBERT J. FLEISCHAKER..... .. .. 130-136

Penicillin-Binding Proteins in Bacteria. NAFSIKA H. GEORGOPA-PADAKOU * AND FUNG Y. LIu ............ 148-157

Affinity ofCefoperazone for Penicillin-Binding Proteins. NOBUYUKIMATSUBARA,* SHINZABURO MINAMI, MICHIO MATSUHASHI,MASAYOSHI TAKAOKA, AND SUSUMU MITSUHASHI .... ....... 195-199

New Translocation Sequence Mediating Tetracycline ResistanceFound in Escherichia coli Pathogenic for Piglets. SIGRID TUEJ0RGENSEN,* BRUNELLO OLIVA, JOHN GRINSTED, AND PETERM. BENNETT......... .. .... 200-205

Physiological Effects and Microbial Susceptibility

In Vitro Antimicrobial Activity of Cefotaxime, a New Cephalospo-rin. SHINJI MASUYOSHI,* SusuMu ARAI, MASAKI MIYAMOTO,AND SUSUMU MITSUHASHI...... 1-8

In Vitro Antimicrobial Susceptibility of Actinobacillus actinomyce-temcomitans. J0RGEN SLOTS,* RICHARD T. EVANS, PHYLLISM. LOBBINS, AND ROBERT J. GENCO... 9-12

Susceptibility of Clostridium botulinum to Thirteen AntimicrobialAgents. JANA M. SWENSON,* CLYDE THORNSBERRY, LORETTAM. MCCROSKEY, CHARLES L. HATHEWAY, AND V. R. DOWELL,JR... 13-19

Asterisk refers to person to whom inquiries regarding the paper should be addressed.

Inhibition of Clinically Significant Bacterial Organisms In Vitro by2-Acetylpyridme Thiosemicarbazones. ARTHUR S. DOBEK,*DANIEL L. KLAYMAN, EDWARD T. DICKSON, JR., JOHN P.SCOVILL, AND EDMUND C. TRAMONT ................ ..... 27-36

Cefotaxime: In Vitro Activity and Tentative Interpretive Standardsfor Disk Susceptibility Testing. PETER C. FUCHS,* ARTHUR L.BARRY, CLYDE THORNSBERRY, RONALD N. JONES, THOMAS L.GAVAN, E. HUGH GERLACH, AND HERBERT M. SOMMERS . 88-93

Metronidazole in Treatment Against Haemophilus vaginalis (Cory-nebacterium vaginale). EDWARD D. RALPH* AND YURI E.AMATNIEKS .......................................... 101-104

Bacteriostatic and Bactericidal Activities of 24 Antimicrobial AgentsAgainst Campylobacter fetus subsp. jejuni. R. VANHOOF,* B.GORDTS, R. DIERICKx, H. COIGNAU, AND J. P. BUTZLER ...... 118-121

Inhibition of Dengue Virus Replication by Amantadine Hydrochlo-ride. WAYNE C. KOFF, * JOE L. ELM, JR., AND ScoTT B.HALSTEAD.......... 125-129

Incidence of Polyene-Resistant Yeasts Recovered from Clinical Spec-imens. J. D. DICK,* W. G. MERZ, AND R. SARAL ..... 158-163

Beta-Lactamase-Producing Isolates of Bacteroides Species fromChildren. ITZHAK BROOK,* LESLIE CALHOUN, AND PAULAYOCUM .......................... 164-166

Radiometric Prescreen for Antitumor Activity with a Saccharomycescerevisiae Mutant Strain. MARILYN K. SPEEDIE,* DOROTHYV. FIQUE, AND RALPH N. BLOMSTER. 171-175

Comparative Bactericidal Effects of Azlocillin and Ticarcillin AgainstPseudomonas aeruginosa. A. R. WHITE, K. R. COMBER, ANDR. SUTHERLAND*.............. 182-189

In Vitro Susceptibility Testing of Paracoccidioides brasiliensis toSulfonamides. ANGELA RESTREPO M.* AND MARIA D.ARANGO ................................................. 190-194

Microdilution Aminoglycoside Susceptibility Testing of Pseudomo-nas aeruginosa and Escherichia coli with a Cation-Supple-mented Inoculum. JOHN E. CHERNE AND LANCE R.PETERSON * .............................................. 210-211

Pharmacology and Therapeutics

Antibacterial Activity of Miloxacin. AKIO IZAWA, YOKo KISAKI,KENJI IRIE, YASUKO EDA, TAKENARI NAKAGOME, AND To-SHIAKI KOMATSU* ............................... 37-40

Absorption and Excretion of Miloxacin in Mice, Rats, andDogs. AKIO IZAWA, AKIRA YOSHITAKE, AND TOSHIAKIKOMATSU* ............................................... 41-44

Determination of Miloxacin and Metabolites in Human Serum andUrine by High-Pressure Liquid Chromatography. AKIRAYOSHITAKE,* KAZUO KAWAHARA, FUMIAKI SHONO, ISAOUMEDA, AKIO IZAWA, AND TOSHIAKI KOMATSU .............. 4549

Biliary Elimination of Mezlocillin: an Experimental and ClinicalStudy. J. M. BROGARD, J. KOPFERSCHMITT, J. P. ARNAUD, M.DORNER, AND J. LAVILLAUREIX* ........................... 69-76

Effects of Impaired Renal Function, Hemodialysis, and PeritonealDialysis on the Pharmacokinetics of Mezlocillin. DIETERKAMPF,* RANDOLF SCHURIG, KLAUS WEIHERMULLER, AND DIE-TER FORSTER ........... .. ....... ...... 81-87

Synergistic Action of Nafcillin and Ampicillin Against Ampicillin-Resistant Haemophilus influenzae Type b Bacteremia andMeningitis in Infant Rats. RAM YOGEV* AND WILLIAM J.KABAT ................................. 122-124

Direct-Current Bactericidal Effect on Intact Skin. L. BOLTON,* B.FOLENO, B. MEANS, AND S. PETRUCELLI.137-141

Ineffectiveness of Adenine Arabinoside and Adenine Arabinoside 5'-Monophosphate in Simian Varicella Infection. KENNETH F.SOIKE,* AMBHAN D. FELSENFELD, SUSAN GIBSON, AND PETERJ. GERONE.142-147

Clinical Trial of Piperacillin with Acquisition of Resistance by Pseu-domonas and Clinical Relapse. GARY L. SIMON, DAVID R.SNYDMAN, FRANCIS P. TALLY, AND SHERWOOD L. GORBACH* 167-170

Comparative Low-Dose Nephrotoxicities of Gentamicin, Tobramy-cin, and Amikacin. G. H. HOTTENDORF* AND LEON L.GORDON.176-181

In Vitro Effect of Rifampin on Serum Bilirubin Determinations.STEVEN MEISEL,* ROBERT PUPKOFF, AND JOHN SVAAN 206-207

Protection of Staphylococci Ingested by Macrophages from Bacteri-cidal Action of Rifampin. EDWARD L. PESANTI.208-209

Hypoxanthine-Arabinoside Pharmacokinetics After Adenine Arabi-noside Administration to a Patient with Renal Failure. GEORGER. ARONOFF,* JAMES J. SZWED, ROBERT L. NELSON, EDWIN L.MARCUS, AND STUART A. KLEIT ........................... 212-214

Volume 18 Contents for August Number2Biosynthesis; Chemistry; Mechanisms of Action and Resistance

Plasmid-Determined Resistance to Fosfomycin in Serratia marces-cens. CARMEN MENDOZA, JUAN M. GARCIA, JUAN LLANEZA,FRANCISCO J. MENDEZ, CARLOS HARDISSON, AND JOSE M.ORTIZ* ..... 215-219

Mode of Action of Copper Complexes of Some 2,2'-Bipyridyl Analogson Paracoccus denitrificans. HENDRIK SMIT, HENDERIKUSVAN DER GOOT,* WIJBE T. NAUTA, PIETER J. PIJPER, SIJBEBALT, MARTINUS W. G. DE BOLSTER, ADRIAN H. STOUTHAMER,HENK VERHEUL, AND RONALD D. VIS ............. .. 249-256

Antiviral Activity of Antilipidemic Compounds on Herpes SimplexVirus Type 1. J. KURT MEHL, DONALD T. WITIAK, VINCENTV. HAMPARIAN, AND JOHN H. HUGHES* .................... 269-275

How Partially Inhibitory Concentrations of Chloramphenicol Affectthe Growth of Escherichia coli. ROBERT J. HARVEY* ANDARTHUR L. KOCH.................... 323-337

Physiological Effects and Microbial SusceptibilityCharacterization of Three Different f8-Lactamases from the Bacte-

roides fragilis Group. BARBRO OLSSON-LILJEQUIST, KATH-RINE DORNBUSCH, AND CARL ERIK NORD* .. ...... 220-225

Classification of Polyene Antibiotics According to Their SynergisticEffect inCombination with BleomycinA2 or Fusidic Acid. SHIN-ICHI AKIYAMA,* TOSHIKO TABUKI, MASAE KANEKO, SOHTAROKOMIYAMA, AND MICHIHIKO KUWANO ............ ...... 226-230

Antifungal and Antibacterial Activities of Diarylamidine Deriva-tives. JOSEF ANNE,* ERIK DE CLERCQ, HENDRIK EYSSEN, ANDOTTo DANN.............. 231-239

Antimycoplasmal Activity of Dimethylphenols in a Tracheal ExplantCulture System. C. COE AGEE,* J. A. ENGELHARDT, AND M.G. GABRIDGE.. 243-248

Substrate-Labeled Fluorescent Immunoassay for Amikacin in Hu-man Serum. STEPHAN G. THOMPSON* AND JOHN F. BURD 264-268

Antiviral Activity of Arildone on Deoxyribonucleic Acid and Ribo-nucleic Acid Viruses. K. S. KIM,* V. J. SAPIENZA, AND R. I.CARP.... 276-280

Effects of Steroid Hormones on Neisseria gonorrhoeae. PAUL G.LYSKO AND STEPHEN A. MORSE*.. 281-288

In Vitro Antibacterial Activity and Susceptibility of the Cephalospo-rin Ro 13-9904 to Beta-Lactamases. KEVIN SHANNON, ANNAKING, CHRISTINE WARREN, AND IAN PHILLIPS*.292-298

In Vitro Activity of Chloramphenicol and Thiamphenicol Analogs.HAROLD C. NEU* AND KWUNG P.Fu................... ..... 311-316

Activity of 2-Acetylpyridine Thiosemicarbazones Against Trypano-soma rhodesiense In Vitro. ROBERT A. CASERO, JR., DANIELL. KLAYMAN,* GEORGE E. CHILDS, JOHN P. SCOVILL, AND ROB-ERT E. DESJARDINS..... 317-322

Comparison of In Vitro Activity of Sch 21420, a Gentamicin BDerivative, with Those of Amikacin, Gentamicin, Netilmicin,Sisomicin, and Tobramycin. C. THORNSBERRY,* A. L. BARRY,R. N. JONES, C. N. BAKER, R. E. BADAL, AND R. R. PACKER.. 338-345

Effect of Clavulanic Acid on Minimal Inhibitory Concentrations of16 Antimicrobial Agents Tested Against Legionella pneumo-phila. DONALD J. POHLOD,* LOUIS D. SARAVOLATZ, EDWARDL. QUINN, AND MARGARET M. SOMERVILLE ........ ... 353-354

In Vitro Activity ofRo 13-9904, Cefuroxime, Cefoxitin, and AmpicillinAgainst Neisseria gonorrhoeae. THOMAS T. YOSHIKAWA, *SHARON A. SHIBATA, PAMELA HERBERT, AND PHYLLIS A. OILL 355-356

Effects of Antituberculosis and Antileprosy Drugs on Mycobacter-iophage D29 Growth. HUGO L. DAVID,* SABINE CLAVEL,FRANSOISE CLEMENT, AND JOSE MONIZ-PEREIRA.... 357-359

Pharmacology and TherapeuticsPharmacokinetics of Ro 13-9904, a Broad-Spectrum Cephalosporin.

M. SEDDON, R. WISE,* A. P. GILLETT, AND R. LIVINGSTON ... 240-242Comparative Activities of Cefotiam and Cefazolin Against Urinary

Tract Infections with Proteus mirabilis in Mice. TOMOYUKIIWAHI AND KANJI TSUCHIYA* ......................... 257-263

Chemotherapy of Babesia microti Infections in MongolianJirds. TRENTON K. RUEBUSH II,* PETER G. CONTACOS, ANDEDGAR A. STECK.289-291

Potential of Mezlocillin as Empiric Single-Agent Therapy in FebrileGranulocytopenic Cancer Patients. JAMES C. WADE,* STE-PHEN C. SCHIMPFF, KATHRYN A. NEWMAN, CLARENCE L. FORT-NER, MARCIA R. MOODY, VIOLA MAE YOUNG, AND PETER H.WIERNIK.. 299-306

Ampicillin Therapy of Experimental Enterococcal Endocarditis.ROBERT R. TIGHT.307-310

Comparative Nephrotoxicities of High-Dose Netilmicin and Tobra-mycin in Rats. RICHARD A. PARKER,* DAVID N. GILBERT,DONALD C. HOUGHTON, GEORGE A. PORTER, AND WILLIAM M.BENNETT... .......... 346-348

Phlebitis Induced by Parenteral Treatment with Flucloxacillin andCloxacillin: a Double-Blind Study. AKE SVEDHEM,* KJELLALESTIG, AND MARIANNE JERTBORN... 349-352

Resistance to Penicillin and Identification of Penicillinase-ProducingNeisseria gonorrhoeae Among Clinical Isolates in Thailand.JOHN W. CRUM,* CHIRAPHUN DUANGMANI, SOMNUK VIBULY-ASEKHA, AND KALAYA SUTHISOMBOON ....................... 360-361

ErrataPurification and Properties of a New f,-Lactamase from Pseudomo-

nas cepacia. K. HIRAI, S. IYOBE, M. INOUE, AND S.MITSUHASHI ................................... 362

Bacteriostatic and Bactericidal Activities of,-Lactam AntibioticsEnhanced by the Addition of Low Concentrations of Gentami-cin. GOHTA MASUDA, KISHIo NAKAMURA, TARO YAJIMA, ANDKAZUE SAKU ............................................. 363

Effect of Orally Administered Probenecid on the Pharmacokineticsof Cefoxitin. PETER H. VLASSES, ANNE M. HOLBROOK, JOHNJ. SCHROGIE, J. DOUGLAS ROGERS, ROGER K. FERGUSON, ANDWILLIAM B. ABRAMS.................... 363

Volume 18 Contents for September Number 3

Biosynthesis; Chemistry; Mechanisms of Action and ResistancePenicillin-Binding Components of Penicillin-Susceptible and -Resist-

ant Strains of Streptococcus pneumoniae. P. B. PERCHESONAND L. E. BRYAN* ............... ........ 390-396

Pyocin Inhibition of Neisseria gonorrhoeae: Mechanism of Action.STEPHEN A. MORSE,* BENJAMIN V. JONES, AND PAUL G.LYSKO ............................. 416-423

Transduction of Methicillin Resistance in Staphylococcus aureus:Recipient Effectiveness and Beta-Lactamase Production.GEORGE C. STEWART AND EUGENE D. ROSENBLUM* .. 424-432

5'-Amino-5'-Deoxythymidine: Synthesis, Specific Phosphorylationby Herpesvirus Thymidine Kinase, and Stability to pH of theEnzymically Formed Diphosphate Derivative. MING S. CHEN,GEORGE T. SHIAU, AND WILLIAM H. PRUSOFF* ... 433-436

Biosynthesis of Daunorubicin Glycosides: Role of E-Rhodomycinone.JEFFREY C. McGUIRE,* MONICA C. THOMAS, RONALD M. STRO-SHANE, BRUCE K. HAMILTON, AND RICHARD J. WHITE ... 454-464

Cell-Free Cyclizatin of 8-(L-a-Aminodipyl)-L-Cysteinyl-D-Valine toIsopenicillin N. YOSUKE SAWADA, JACK E. BALDWIN, PUSHPAD. SINGH, NADINE A. SOLOMON, AND ARNOLD L. DEMAIN* 465470

pJT2: Unusual Hi Plasmid in a Highly Virulent Lactose-Positiveand Chloramphenicol-Resistant Salmonella typhimuriumStrain from Calves. J. F. TIMONEY,* DIANE E. TAYLOR, S.SHIN, AND P. MCDONOUGH ................................ 480-482

Physiological Effects and Microbial SusceptibilityIncidence of Thymidine-Dependent Enterococci Detected on Muel-

ler-Hinton Agar with Low Thymidine Content. RITA C. HAL-TINER, PAULA C. MIGNEAULT, AND RICHARD G. ROBERTSON* 365-368

Induction of f-Lactamase by Various ,B-Lactam Antibiotics in Enter-obacter cloacae. SHINZABURO MINAMI,* AKIRA YOTSUJI,MATSUHISA INOUE, AND SUSUMU MITSUHASHI .. 382-385

Susceptibility of Legionella pneumophila to Twenty AntimicrobialAgents. PAUL H. EDELSTEIN* AND RICHARD D. MEYER ..... 403-408

In Vitro Susceptibility of Varicella-Zoster Virus to Acyclovir. KARENK. BIRON* AND GERTRUDE B. ELION.... 443-447

Lack of Toxicity of Acyclovir to Granulocyte Progenitor Cells inVitro. ROBERT W. MCGUFFIN, FAITH M. SHIOTA, AND JOEL D.MEYERS* ............. 471-473

Prevalence of Ampicillin-Resistant Strains of Haemophilus influ-enzae Causing Systemic Infection. STEPHEN J. LERMAN,* JANM. BRUNKEN, AND MITzI BOLLINGER ...... ... 474-475

In Vitro Susceptibility of Gram-Negative Bacilli from Pediatric Pa-tients to Moxalactam, Cefotaxime, Ro 13-9904, and Other Ceph-alosporins. SHARON SHELTON, JOHN D. NELSON,* ANDGEORGE H. MCCRACKEN, JR............................... 476-479

In Vitro Activity of Cefoperazone Against Nonfermenters and Aero-monas hydrophila. ROBERT J. FASS .... .... 483-486

Tentative Interpretive Criteria for the Diffusion Susceptibility TestUsing 30-,ug Netilmicin Disks. RONALD N. JONES,* ARTHUR L.BARRY, AND CLYDE THORNSBERRY ...... ................... 487-490

Pharmacology and TherapeuticsComparison of Cefotaxime and Moxalactam Pharmacokinetics and

Tissue Levels. R. WISE,* S. BAKER, AND R. LIVINGSTON .... 369-371Pharmacokinetic Studies with Dibekacin, a New Aminoglycoside,

After Intravenous and Intramuscular Administration to HumanVolunteers. MITSUYOSHI GOTO,* MASATOSHI SUGIYAMA, ANDTAKASHI ISHIZAKI ............... ...... ........ 372-376

New In Vitro Kinetic Model for Evaluating Bactericidal Efficacy ofAntibiotics. TAKEO MURAKAWA, HIROSHI SAKAMOTO, TOSHI-HARU HIROSE, AND MINORU NISHIDA*.. 377-381

Phannacokinetics of Cefmetazole in Normal Subjects and in Patientswith Impaired Renal Function. MITSUO OHKAWA,* MATSUOORITO, TOSHIAKI SUGATA, MASAYOSHI SHIMAMURA, MASARUSAWAKI, EINOSUKE NAKASHITA, KYOICHI KURODA, AND KUNI-HIRO SASAHARA .......................................... 386-389

Cephamycin C Treatment of Induced Enterotoxigenic Colibacillosis(Scours) in Calves and Piglets. THOMAS M. JACKS,* KLAUS-DIETER SCHLEIM, FREDERICK R. JUDITH, AND BRINTON M.MILLER ............................................... 397-402

Modified Polyriboinosinic-Polyribocytidylic Acid Complex: Modula-tion of Toxicity for Rabbits by Alterations in Components.BIENVENIDO G. GATMAITAN, HILTON B. LEVY, AND A. MARTINLERNER* .................... 409-415

Carbenicillin plus Cefazolin with or Without Mecillinam as an EarlyTreatment of Bacteremia Caused by Gram-Negative Organsms:Randomized Double-Blind Study. J. KLASTERSKY,* L. Cop-PENS, F. MEUNIER-CARPENTIER, AND A. P. MENDAY .... ..... 437-442

Prophylaxis Against Enterococcal Endocarditis: Comparison of theAminoglycoside Component of Parenteral Antimicrobial Regi-mens. JORGE MURILLO, HAROLD C. STANDIFORD,* H. PRES-TON HOLLEY, BEVERLY A. TATEM, AND ELLIS S. CAPLAN ..... 448-453

ErrataInhibition of Clinically Significant Bacterial Organisms In Vitro by

2-Acetylpyridine Thiosemicarbazones. ARTHUR S. DOBEK,DANIEL L. KLAYMAN, EDWARD T. DICKSON, JR., JOHN P. SCOV-ILL, AND EDMUND C. TRAMONT ......................... 491

Absorption and Disposition Kinetics of Amoxicillin in Nornal Hu-man Subjects. A. ARANCIBIA, J. GUTTMAN, G. GONZALEZ, ANDC. GONZALEZ ............................................. 491

Combined Antibacterial Activity of Amoxicillin with Clavulanic AcidAgainst Ampicillin-Resistant Strains. M. MATSUURA, H. NAKA-ZAWA, T. HASHIMOTO, AND S. MITSUHASHI .............. .... 491

Volume 18 Contents for October 1980 Number 4

Biosynthesis; Chemistry; Mechanism of Action and Resistance

Tetracycline Transport in Bacteroides fragilis. FRANCOISE FAY-OLLE, GAETANO PRIVITERA,* AND MADELEINE SEBALD.502-505

Enzymatic Method for Rapid and Sensitive Determination of f8-Lactam Antibiotics. JEAN-MARIE FRERE, DANIEL KLEIN, ANDJEAN-MARIE GHUYSEN* .................................. 506-510

Effects of Potassium and Sodium Ions on the Killing Action of aPichia kluyveri Toxin in Cells of Saccharomyces cerevisiae.EVERT J. MIDDELBEEK,* ANS Q. H. CRUTZEN, AND GODFRIEDD. VOGELS.519-524

Influence of Chemical Modification of Na-Cocoyl-L-Arginine EthylEster on Its Hepatitis B Surface Antigen-Inactivating Effect.YOSHIKAZU SUGIMOTO* AND SHIGESHI TOYOSHIMA .......... 525-528

Neomycin Inhibition of Adenosine Triphosphatase: Evidence for aNeomycin-Phospholipid Interaction. JAMES J. LIPSKY* ANDPAUL S. LIETMAN .............. .......................... 532-535

Klebsiella Neonatal Infections: Mechanism of Broadening Amino-glycoside Resistance. D. J. HARDY, R. J. LIEGEAI, AND R. J.O0CALLAGHAN* .. ...... ... ........... 542-548

Relationship Between Metronidazole Metabolism and BactericidalActivity. EWAN J. T. CHRYSTAL, RONALD L. KOCH, MARTHAA. MCLAFFERTY, AND PETER GOLDMAN* ................... 566-573

Characterization of Chloramphenicol-Resistant Haemophilus influ-enzae. MARILYN C. ROBERTS,* CHRISTINA D. SWENSON, LYNNM. OWENS, AND ARNOLD L. SMITH ....... .................. 610-615

In Vivo Interaction of ,B-Lactam Antibiotics with the Penicillin-Binding Proteins of Streptococcuspneumoniae. RUSSELL WIL-LIAMSON, REGINE HAKENBECK, AND ALEXANDER TOMASZ* ... 629-637

Physiological Effects and Microbial SusceptibilityComparative In Vitro Appraisal of Piperacillin, Including Its Activity

Against Salmonella typhi. RoY G. ROBINSON, JEAN SAUN-DERS, ROBERT CASSEL, COLIN S. BLOCK, AND HENDRIK J.KOORNHOF* ........ ............... 493-501

In Vitro Susceptibility of Mycobacterium marinum to Eight Anti-microbial Agents. WILLIAM J. SANDERS AND EMANUELWOLINSKY* ... ....... ... .... ....... 529-531

Enhancement of Activity Against Influenza Viruses by Combinationsof Antiviral Agents. FREDERICK G. HAYDEN, R. GORDONDOUGLAS, JR.,* AND RUTH SIMONS ......................... 536-541

In Vitro Activity of N-Formimidoyl Thienamycin (MK0787), a Crys-talline Derivative of Thienamycin. VICTOR W. HORADAM,JERRY D. SMILACK,* CAROL L. MONTGOMERY, AND JURGENWERRINGLOER... 557-561

In Vitro Evaluation of Ro 13-9904. ANNE M. HINKLE AND GERALDP. BODEY*.574-578

Antimicrobial Susceptibility Testing of Streptococcus pneumoniaeby Micro-Broth Dilution. MARTHA M. TARPAY,* DAVID F.WELCH, AND MELVIN I. MARKS ............................ 579-581

Synergistic Activity of Piperacillin in Combination with f?-LactamaseInhibitors. HAROLD C. NEU* AND KWUNG P. Fu... 582-585

Permeabilizing and Hemolytic Action of Large and Small PolyeneAntibiotics on Human Erythrocytes. JANINA BRAJTBURG,*GERALD MEDOFF, GEORGE S. KOBAYASHI, SVETLANA ELBERG,AND CAROLYNN FINEGOLD... .... 586-592

Influence of Extracellular K+ or Mg2e on the Stages of the AntifungalEffects of Amphotericin B and Filipin. JANINA BRAJTBURG,*GERALD MEDOFF, GEORGE S. KOBAYASHI, AND SVETLANAELBERG ................. 593-597

Interpretive Standards for Disk Susceptibility Tests with Sch 21420and Amikacin. ARTHUR L. BARRY,* CLYDE THORNSBERRY,RONALD N. JONES, AND E. HUGH GERLACH........ 616-621

Comparative Studies of Interferon and Three Antiviral Agents onNeurotropic and Oncogenic Herpesviruses. MUTHIAH D. DAN-IEL,* LAWRENCE A. FALK, NORVAL W. KING, RUTH TAMULE-VICH, JAMES S. HOLLAND, AND J. GEORGE BEKESI.622-628

Bactericidal Activity of Cerumen. TUU-JYI CHAI* AND TOBY C.CHAI................................ 638-641

In Vitro Activity of N-Formimidoyl Thienamycin (MK0787). FRAN-CIS P. TALLY,* NILDA V. JACOBUS, AND SHERWOOD L.GORBACH ............................... 642-644

Comparative In Vitro Activity of Moxalactam, Cefotaxime, Cefo-perazone, Piperacillin, and Aminoglycosides Against Gram-Neg-ative Bacilli. TERRANCE 0. KURTZ, DREW J. WINSTON, JANETA. HINDLER, LOWELL S. YOUNG, WILLIAM L. HEWITT, ANDWILLIAM J. MARTIN*... 645-648

Pharmacology and TherapeuticsMetabolic Fate of SCE-1365, a New Broad-Spectrum Cephalosporin,

After Parenteral Administration to Rats and Dogs. SHIGEHARUTANAYAMA,* KIYOSHI YOSHIDA, KIMIKO ADACHI, AND TAKAOKONDO .... ... ... ........... ..... ............. 511-518

Therapeutic Effects of Cefotiam and Cefazolin on ExperimentalPneumonia Caused by Klebsiella pneumoniae DT-S inMice. TAKESHI NISHI AND KANJI TSUCHIYA*............. 549-556

Comparison of Ceforanide, Cefazolin, Methicillin, and Nafcillin inStaphylococcus aureus Endocarditis Therapy in Rabbits. J.CARRIZOSA, W. D. KOBASA, AND D. KAYE*.................. 562-565

Erythro-9-(2-Hydroxy-3-Nonyl)Adenine Alone and in Combinationwith 9-fl-D-Arabinofuranosyladenine in Treatment of SystemicHerpesvirus Infections in Mice. WILLIAM M. SHANNON,* GUS-SIE ARNETT, FRANK M. SCHABEL, JR., THOMAS W. NORTH, ANDSEYMOUR S. COHEN.... 598-603

Animal Model Distinguishing In Vitro from In Vivo Carbenicillin-Aminoglycoside Interactions. JOHN A. PIEPER, RONALD A. VI-DAL, AND JEROME J. SCHENTAG* ........ ... 604-609

Erratum

In Vitro Antimicrobial Susceptibility of Actinobacillus actinomyce-temcomitans. J0RGEN SLOTS, RICHARD T. EVANS, PHYLLIS M.LOBBINS, AND ROBERT J. GENCO ........................... 649

Volume 18 Contents for November Number 5

Biosynthesis; Chemistry; Mechanisms of Action and ResistanceCharacterization of fi-Lactamase-Deficient (bla) Mutants of the R

Plasmid Rl in Escherichia coli K-12 and Comparison withSimilar Mutants of RP1. IAN CROWLESMITH AND T. G. B.HOWE* ................................... 667-674

Quantitative Correlation Between Penicillin Resistance and 8-Lac-tamase Activity Specified by the R Plasmids Rl, Rl bla-45, andRP1 in Escherichia coli K-12. IAN CROWLESMITH AND T. G.B. HOWE* ... ... ................................. 675-679

Purification and Biochemical Properties of fi-Lactamase Producedby Proteus rettgeri. MASAYUKI MATSUURA, HISASHI NAKA-ZAWA, MATSUHISA INOUE,* AND SUSUMU MITSUHASHI ....... 687-690

Gentamicin Uptake in Wild-Type and Aminoglycoside-ResistantSmall-Colony Mutants of Staphylococcus aureus. MICHAEL H.MILLER,* STEPHEN C. EDBERG, LAURA J. MANDEL, CAREN F.BEHAR, AND NEAL H. STEIGBIGEL ......................... 722-729

Penicillin-Binding Proteins of Penicillin-Susceptible and IntrinsicallyResistant Neisseria gonorrhoeae. THOMAS J. DOUGHERTY,*ANTJE E. KOLLER, AND ALEXANDER TOMASZ ................ 730-737

Inhibition of Cellular a and Virally Induced Deoxyribonucleic AcidPolymerases by the Triphosphate of Acyclovir. MARTY H. ST.CLAIR,* PHILLIP A. FURMAN, CAROL M. LUBBERS, AND GER-TRUDE B. ELION .......................................... 741-745

Identification of Tetracycline-Resistant R-Plasmids in Streptococcusagalactiae (Group B). VICKERS BURDETT.753-760

Synthesis of 3-O-Demethylfortimicins. JERRY R. MARTIN,* PAU-LETTE JOHNSON, JACK TADANIER, AND ALMA GOLDSTEIN 761-765

Penicillinase-Producing Neisseria gonorrhoeae in the Netherlands:Epidemiology and Genetic and Molecular Characterization ofTheir Plasmids. J. D. A. VAN EMBDEN,* B. VAN KLINGEREN,M. DESSENS-KROON, AND L. J. VAN WIJNGAARDEN .......... 789-797

Interaction Between Aminoglycoside Uptake and Ribosomal Resist-ance Mutations. M. H. AHMAD, ANGELIKA RECHENMACHER,AND AUGUST BOCK* ......................... ........ 798-806

Plasmids in Corynebacterium diphtheriae and Diphtheroids Me-diating Erythromycin Resistance. JOHN SCHILLER, NEAL GRO-MAN,* AND MARIE COYLE ................................. 814-821

Growth and Antifungal Homoazasterol Production in Geotrichumflavo-brunneum. R. J. RODRIGUEZ AND L. W. PARKS* 822-828

Binding of,-Lactam Antibiotics to Penicillin-Binding Proteins ofStaphylococcus aureus and Streptococcus faecalis: Relation toAntibacterial Activity. NAFSIKA H. GEORGOPAPADAKOU * ANDFUNG Y. LIU... 834-836

Physiological Effects and Microbial SusceptibilityComparative Susceptibilities of Clinical Isolates of Serratia marces-

cens to Newer Cephalosporins, Alone and in Combination withVarious Aminoglycosides. SHELDON M. MARKOWITZ* ANDDENISE J. SIBILLA............... ... ..... ..... 651-655

Effect of Beta-Lactamase and Salt on Mecillinam Susceptibility ofEnterobacterial Strains. GER P. A. BONGAERTS* AND KRIS-TIANE M. BRUGGEMAN-OGLE ............................ 680-686

Stimulation of Leucomycin Production by Magnesium Phosphateand Its Relevance to Nitrogen Catabolite Regulation. SATOSHIOMURA,* YOSHITAKE TANAKA, CHIAKI KITAO, HARUO TANAKA,AND YUZURU IWAI.691-695

Relative Resistance to Erythromycin in Chlamydia trachomatis.ALY MOURAD, RICHARD L. SWEET, NANCY SUGG, AND JULIUSSCHACHTER*... 696-698

Method for Reliable Determination of Minimal Lethal AntibioticConcentrations. RICHARD D. PEARSON, Roy T. STEIGBIGEL,*HENRY T. DAVIS, AND STANLEY W. CHAPMAN.699-708

Tentative Interpretive Standards for Disk Susceptibility Tests withMoxalactam (LY127935). A. L. BARRY,* C. THORNSBERRY, R.N. JONES, AND E. H. GERLACH...... 716-721

In Vitro Antimicrobial Activity of Rosoxacin Against Neisseria gon-orrhoeae, Chlamydia trachomatis, and Ureaplasma urealyti-cum. RICHARD A. DOBSON,* JOHN R. O'CONNOR, SHARON A.POULIN, RUTH B. KUNDSIN, THOMAS F. SMITH, AND PAUL E.CAME .............. ....... 738-740

Comparative Antimicrobial Activity of O-Demethylfortimicin A, aDerivative of Fortimicin A. ROLAND L. GIROLAMI* AND JOHNM. STAMM....... 766-772

Compound A49759, a 3-O-Demethyl Derivative of Fortimicin A: InVitro Comparison with Six Other Aminoglycoside Antibiotics.RONALD N. JONES,* CLYDE THORNSBERRY, ARTHUR L. BARRY,RICHARD R. PACKER, CAROLYN N. BAKER, AND ROBERT E.BADAL......................... 773-779

High-Pressure Liquid Chromatographic Method for Determinationof Rosaramicin in Humans. C. LIN,* H. KIM, D. SCHUESSLER,E. ODEN, AND S. SYMCHOWICZ ............................. 780-783

Effect of Storage and Changes in Bacterial Growth Phase and Anti-biotic Concentrations on Antimicrobial Tolerance in Staphylo-coccus aureus. C. GLEN MAYHALL* AND ELAINE APOLLO 784-788

Killing of Oxacillin-Exposed Staphylococci in Human Polymorpho-nuclear Leukocytes. VICTOR LORIAN* AND BARBARAATKINSON..... 807-813

Susceptibility of Eikenella corrodens to Newer Beta-Lactam Anti-biotics. ELLIE J. C. GOLDSTEIN,* MYLES E. GOMBERT, ANDEMMANUEL 0. AGYARE.8324833

Effect of N-Formimidoyl Thienamycin (MK0787) on f?-Lactamasesand Activity Against ,B-Lactamase-Producing Strains. M.TODA,* K. SATO, H. NAKAZAWA, M. INOUE, AND S.MITSUHASHI.837-838

Pharmacology and TherapeuticsPharmacokinetic Comparison of Cefroxadin (CGP 9000) and Ce-

phalexin by Simultaneous Administration to Humans. JEANB. LECAILLON,* JEAN L. HIRTZ, JEAN P. SCHOELLER, GUYHUMBERT, AND WOLFGANG VISCHER ....................... 656-660

Effect of Prednisolone and Rifampin on Isoniazid Metabolism inSlow and Rapid Inactivators of Isoniazid. G. RAGHUPATISARMA, S. KAILASAM, N. G. K. NAIR, A. S. L. NARAYANA, ANDS. P. TRIPATHY*.661-666

Pharmacology, Tolerance, and Antiviral Activity of VidarabineMonophosphate in Humans. RICHARD J. WHITLEY,* BRUCE C.TUCKER, ARLYN W. KINKEL, NANCY H. BARTON, ROBERT F.

PASS, JOHN D. WHELCHEL, C. GLENN COBBS, ARNOLD G.DIETHELM, AND ROBERT A. BUCHANAN.709-715

Bioavailability and Metabolism of Potassium Phosphanilate in Lab-oratory Animals and Humans. FRANCIS H. LEE,* DONALD R.VAN HARKEN, MICHAEL VASILJEV, ROBERT D. SMYTH, AND G.H. HOTTENDORF.... 746-752

Influence of Food on Absorption of Erythromycin Ethyl Succinate.PHILIP J. THOMPSON, KEITH R. BURGESS, AND GRAHAM E.MARLIN * ... ...... ................ ...... 829-831

ErratumFactors Affecting Gentamicin Assay. LENNART NILSSON .......... 839

Volume 18 Contents for December Number 6Biosynthesis; Chemistry; Mechanisms of Action and Resistance

Purification and Properties of a Cephalosporinase from Enterobac-ter cloacae. SHINZABURO MINAMI,* MATSUHISA INOUE, ANDSUSUMU MITSUHASHI..... 853-857

Uptake of Indolmycin in Gram-Positive Bacteria. ROLF G.WERNER ........................... 858-862

Binding of Cycloheximide to Ribosomes from Wild-Type and MutantStrains of Saccharomyces cerevisiae. WALTER STOCKLEIN*AND WOLFGANG PIEPERSBERG ........ ..................... 863-867

Inhibition of Peptidoglycan Synthesis in Ether-Permeabilized Esch-erichia coli Cells by Structural Analogs of D-Alanyl-D-Alarnie. HELMUT PELZER* AND WOLFGANG REUTER ....... 889-892

R-Factor Responsible for an Outbreak of Multiply Antibiotic-Resist-ant Klebsiella pneumoniae. MARY-ANNE COURTNEY, JAMESR. MILLER, JAMES SUMMERSGILL, JULIO MELO, MARTIN J.RAFF, AND ULDIS N. STREIPS* .. ..... ... 926-929

Replacement of Animal Serum Proteins by Human Albumin forGrowth and Interferon Production by Namalva Cells. A. KIRKFIELD,* EDGAR M. SCATTERGOOD, CHARLES J. HOPKE, ALFREDA. TYTELL, AND MAURICE R. HILLEMAN .................... 930-932

Anti-Herpes Simplex Virus and Anti-Human Cell Growth Activityof E-5-Propenyl-2'-Deoxyuridine and the Concept of SelectiveProtection in Antivirus Chemotherapy. YUNG-CHI CHENG,*SUSAN GRILL, JERRY RUTH, AND DONALD E. BERGSTROM .... 957-961

Interaction of Polyunsaturated Fatty Acids with Animal Cells andEnveloped Viruses. A. KOHN,* J. GITELMAN, AND M. INBAR 962-968

Physiological Effects and Microbial SusceptibilityIn Vitro Susceptibility Haemophilus equigenitalis, the Causative

Organism of Contagious Equine Metritis 1977, to AntimicrobialAgents.-HENRY J. DABERNAT,* CATHERINE F. DELMAS, DAN-IEL J. TAINTURIER, AND MARIE B. LARENG... 841-843

Comparison of Sensititre Dried Microtitration Trays with a StandardAgar Method for Determination of Minimum Inhibitory Con-centrations of Antimicrobial Agents. DAVID S. REEVES, ALANHOLT, MARTIN J. BYWATER, RICHARD WISE, MARGARET N.LOGAN, JENNY M. ANDREWS, AND JOHN M. BROUGHALL* ... 844-852

Differences Among Providencia Species in Their In Vitro Suscepti-bilities to Five Antibiotics. J. L. PENNER* AND M. A.PRESTON.868-871

In Vitro Antagonism by Erythromycin of the Bactericidal Action ofAntimicrobial Agents Against Common Respiratory Patho-gens. JOHN R. COHN, * DONALD L. JUNGKIND, AND JOHN S.BAKER ................................................ 872-876

Klebsiella Species: Antimicrobial Susceptibilities, Bactericidal Ki-netics, and In Vitro Inactivation ofBeta-Lactam Agents. ANANDP. PANWALKER, GARY M. TRAGER,* AND PRISCILLA E.POREMBSKI...... 877-881

Influence of Inoculum Size on Activity of Cefoperazone, Cefotaxime,Moxalactam, Piperacillin, and N-Formimidoyl Thienamycin(MK0787) Against Pseudomonas aeruginosa. MICHAEL L.CORRADO,* SHELDON H. LANDESMAN, AND CHARLES E.CHERUBIN........ ... 893-896

Phosphonopeptide Antibacterial Agents Related to Alafosfalin: De-sign, Synthesis, and Structure-Activity Relationships. FRANKR. ATHERTON, MICHAEL J. HALL, CEDRIC H. HASSALL,* SIMONW. HOLMES, ROBERT W. LAMBERT, WILLIAM J. LLOYD, ANDPETER S. RINGROSE... ... .. 897-905

Activity of Mecillinam Alone and in Combination with Other ,B-Lactam Antibiotics. ROBERT J. FASS .... .. 906-912

Two-Hospital Study of Staphylococcus aureus Susceptibility to Pen-icillin and Ampicillin by Autobac I. PATRICIA C. HARRIS* ANDLYNN B. SEALEY...... .. 922-925

CI-867, a New Semisynthetic Penicillin: In Vitro Studies. SUSANNES. WEAVER AND GERALD P. BODEY* .. .. ........ .. 939-943

Synergy of Penicillin and Decreasing Concentrations of Aminogly-cosides Against Enterococci from Patients with Infective Endo-carditis. JOSEPH Y. MATSUMOTO,* WALTER R. WILSON, ALANJ. WRIGHT, JOSEPH E. GERACI, AND JOHN A. WASHINGTON II 944-947

Antimicrobial Susceptibility of Campylobacterjejuni and Campylo-bacter fetus subsp. fetus to Eight Cephalosporins with SpecialReference to Species Differentiation. M. A. KARMALI, S. DEGRANDIS, AND P. C. FLEMING*. 948-951

Morphological Expressions of Antibiotic Synergism Against Pseu-domonas aeruginosa as Observed by Scanining Electron Micros-COPY. STEVEN J. WAISBREN, DAVID J. HURLEY, AND BURTONA. WAISBREN* ........................................... 969-975

Corynebacterium equi: In Vitro Susceptibility to Twenty-Six Anti-microbial Agents. JOHN B. WOOLCOCK* AND MALCOLM D.MUTIMER........ .... .......... 976-977

In Vitro Activity of Rosaramicin Against Chlamydia tracho-matis. W. R. BOWIE.... ... .. 978-979

Pharmacology and TherapeuticsEffect of Meningitis and Probenecid on the Penetration of Vanco-

mycin into Cerebrospinal Fluid in Rabbits. DANIEL P. KRONTZAND LARRY J. STRAUSBAUGH* ... .... 882-886

Ro 13-9904, a Long-Acting Broad-Spectrum Cephalosporin: In Vitroand In Vivo Studies. PETER ANGEHRN,* PETER J. PROBST,ROLAND REINER, AND RUDOLF L. THEN .. .. ... ... 913-921

Pharmacokinetics of Moxalactam in Subjects with Various Degreesof Renal Dysfunction. W. KLINE BOLTON,* W. MICHAELSHELD, DANIEL A. SPYKER, TERRY L. OVERBY, AND MERLE A.SANDE.. 933-938

Pharmacokinetics of Mecillinam in Healthy Subjects. JOHN G.GAMBERTOGLIO,* STEVEN L. BARRIERE, EMIL T. LIN, AND JOHNE. CONTE, JR. ............................................ 952-956

Cefoperazone Concentrations in Bile and Gall Bladder Wall AfterIntravenous Administration. TAKASHI NAKAMURA, * IKUOHASHIMOTO, YASUO SAWADA, JIROH MIKAMI, EIICHI BEKKI,SADAKO HIRASAWA, HIROMu ABE, AND YASUO WATANABE ... 980-982

Comparative Nephrotoxicities of Dibekacin, Amikacin, and Genta-micin in a Rat Model. LAURA L. RANKIN,* FRIEDRICH C. LUFT,Moo N. YUM, AND LINDA L. ISAACS ...... .................. 983-985

ErratumpJT2: Unusual Hi Plasmid in a Highly Virulent Lactose-Positive

and Chloramphenicol-Resistant Salmonella typhimuriumStrain from Calves. J. F. TIMONEY, DIANE E. TAYLOR, S. SHIN,AND P. MCDONOUGH ..................................... 986

INDEX TO DATE OF ISSUE

Month Date of Issue PagesJuly 30 July 1980 1-214August 4 September 1980 215-363September 22 September 1980 365-491October 13 October 1980 493-649November 13 November 1980 651-839December 26 December 1980 841-987