Anti Pyre Tics

Click here to load reader

  • date post

    06-Apr-2018
  • Category

    Documents

  • view

    217
  • download

    0

Embed Size (px)

Transcript of Anti Pyre Tics

  • 8/3/2019 Anti Pyre Tics

    1/17

    ANTIPYRETICSPRESENTED BY-

    BRUCHELLE PEREIRA.

    DISHA DHAIRYAWAN.

    DR KAVITA BADGUJAR.

    DR PARAG SARVE.

    MSC CR (2010-12), ICRI MUMBAI.

  • 8/3/2019 Anti Pyre Tics

    2/17

    CONTENTS

    INTRODUCTION

    DRUG INFORMATION

    DOSAGE FORMS RECENT DEVELOPMENTS

  • 8/3/2019 Anti Pyre Tics

    3/17

    INTRODUCTION

    Antipyretic drugs are class of drugs that are

    used to prevent or reduce fever.

    Do not affect normal body temperature.

    Reduce body temperature from raised state

    in case of bacterial or viral triggered defense

    mechanism.

  • 8/3/2019 Anti Pyre Tics

    4/17

    DRUG INFORMATION

    PARACETAMOL

    It is a type of NSAIDS(non steroidal anti-

    inflammatory drugs). Deacetylated active metabolite of phenacetin

    Chemical name - Para-aminosalicyclic acid.

    Non-proprietary name Acetaminophen.

    Proprietary name (Brand name) Crocin,Calpol, Panadol etc.

  • 8/3/2019 Anti Pyre Tics

    5/17

    DRUG INFORMATION CONTD.

    Mechanism of action-

    Inhibits synthesis of prostaglandins in the

    CNS and peripherially blocks pain impulse.Hence also used as analgesic widely.

    Decreased levels of prostaglandins leads to

    decreased effect of microbial pyrogens onheat regulating centers in brain & produces

    antipyresis.

  • 8/3/2019 Anti Pyre Tics

    6/17

    DRUG INFORMATION

    PARACETAMOL

    Dosage according to age -

    Infants :50mg.

    Children (1-3yrs ): 80-160 mg.(4-8yrs): 240-320mg.

    (9-12yrs): 300-600 mg.

    Adults: 0.5 -1g TDS (total daily dose ) not toexceed 2.5g .

  • 8/3/2019 Anti Pyre Tics

    7/17

    DRUG INFORMATION CONTD

    Advantages of Paracetamol-

    Well tolerated & Safe.

    Does not lead to gastric irritation, ulceration or

    bleeding as in case of aspirin.No significant drug interactions.

    Hypersensitivity is rare.

    No acid-base disturbances.

    Safely used in infants, pregnant, lactatingwomen & in patients where NSAIDScontraindicated .

  • 8/3/2019 Anti Pyre Tics

    8/17

    DRUG INFORMATION CONTD

    PARACETAMOL is available in various oral &parenteral dosage forms.

  • 8/3/2019 Anti Pyre Tics

    9/17

    PARACETAMOL TABLETS.

    Dose 500 mg, 1.0g .

    Brand name Crocin , Calpol, Panadol.

    Manufacturers Glaxosmithklinepharmaceuticals (crocin), Aurobindo pharma,

    Cipla limited etc.

    Glaxosmithkline in 2003 has launched Crocinpain relief containing paracetamol&caffeine

    as actives.

  • 8/3/2019 Anti Pyre Tics

    10/17

    PARACETAMOL CAPSULES

    DOSE- 500 mg -1g.

    Can be used in children over 12yrs.

    Brand name -Boots Paracetamol capsulesMfg by Boots pharmaceuticals .

  • 8/3/2019 Anti Pyre Tics

    11/17

    PARACETAMOL SYRUP

    DOSE 125mg/5 ml , 150mg / ml syrup.

    Brand name- Aeknil syrup drops, Metacin,

    Paracin ,Apecin paracetamol syrup etc Manufacturers Arihant pharmaceutical

    works (Apecin), Therapeutic pharmaceuticals

    (Aeknil syrup ).

  • 8/3/2019 Anti Pyre Tics

    12/17

    PARACETAMOL ELIXIR

    Paracetamol dissolved in defined quantities of

    alcohol.

    Dose 120mg/5ml. Dose repeated every 4hrsupto 4 times a day.

    Brand name - Panadol Paracetamol elixir.

    Manufactured by- Cynosure pharma UK

  • 8/3/2019 Anti Pyre Tics

    13/17

    PARACETAMOL SUSPENSION

    Dose -150mg/5ml

    Brand name Crocin suspension in strawberry

    flavour (1-5 yrs of children) Crocin suspension double strength in mixed

    fruit flavour (5-12yrs) .

    Manufactured by Glaxosmithkline .

  • 8/3/2019 Anti Pyre Tics

    14/17

    PARACETAMOL I.M INJECTION

    Dose 150mg/ml.

    Brand name- Aeknil Paracetamol I.M injection.

    Manufactured by Aeknil Pharmaceuticals

    Uses febrile convulsion , post operative

    trauma , when oral medication is not possible.

  • 8/3/2019 Anti Pyre Tics

    15/17

    PARACETAMOL SUPPOSITORIES

    Dose 300mg per suppository

    Used in paedriatic patients for mild to

    moderate pain & fever. Brand name Doliprane

    Manufactured by Aventis pharma.

  • 8/3/2019 Anti Pyre Tics

    16/17

    RECENT DEVELOPMENTS

    FDA approval for Acetavance Paracetamol I.Vinjection by Cadence pharmaceuticals on2ndNov 2010.

    Antipyretics like paracetamol , aspirin,dipyrine are used for modifying the labellingblood elements with tectnetium(nuclearmedicine).

    Crocin quick works twice times as regularparacetamol tablet launched by GSK .

  • 8/3/2019 Anti Pyre Tics

    17/17

    THANK YOU !!!