Anti Hemostatic Drugs
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Transcript of Anti Hemostatic Drugs
ANTI - HEMOSTATIC DRUGS
• ANTI THROMBOTIC
• THROMBOLYTIC DRUGS
• ANTI COAGULANTS
ANTI THROMBOTIC• Anti platelet drug• Aspirin-Low dose (80-160 mg)• • Ticlopidine• Clopidogrel
• Mab –
• Dipyridamole • Pentoxiphylline
Dipyridamole
(-)
Platelet activation
Pentoxiphylline
• Xanthine analogue
• Increases deformability of RBCs thus increases microcirculation, reduce fibrinogen levels, inhibit pl. aggregation.
• Uses-CVAs esp.TIA(transient ischemic attacks) , Ischemic ulcers of legs
Anti fibrinolytic
• Streptokinase• • Staphylokinase
• Alteplase=t-PA
• Reteplase =U-PA
• Tenecteplase
ANTICOAGULANTS
ENDOGENOUS EXOGENOUS
ANTICOAGULANTS
ENDOGENOUS
1. HEPARIN2. ANTOTHROMBIN III3. PROTEIN C4. α2 MACROGLOBULIN
EXOGENOUS
1. HEPARIN2. VIT K ANTAGONISTS3. Ca SEQUESTERS4. DEFIBRINATION
SUBSTANCES5. COLD6. HIRUDIN
ANTICOAGULANTS
• FOR BLOOD COLLECTION
• FOR TREATMENT
ANTICOAGULANTS
• FOR BLOOD COLLECTION
1. HEPARIN2. Ca SEQUESTERS3. COLD
• FOR TREATMENT
• HEPARIN
CALCIUM SEQUESTERS• MOA
• OXALATES• CITRATE • TRISODIUM CITRATE• EDTA• SODIUM FLUORIDE• HEPARIN
OXALATES• Acts by insoluble salts with calcium in blood to
ppt Ca • Ammonium :Potassium oxalate =2:3
• 2mg/dl
• Uses • PCV• ESR
CITRATE
• Acts by deionisation of calcium in blood
• Blood banks• ACD• CPD• CPD-A
• 0.4 ml Na citrate in 1.6mlof blood
TRISODIUM CITRATE
• 3.8%
EDTA
• Sequester or chelating effect on calcium
• 1mg/dl
• ESR• PT
• Uses- routine blood tests
Three types of EDTA salt – sodium potassium lithiumDipotassium salt more soluble than Disodium salt, hence preferred
SODIUM FLUORIDE
• deionisation of calcium in blood
FIBRINOGENPTPTTESR(by westergren method)
USES
COLD
• 5-10 0C
ANTICOAGULANTS FOR TREATMENT
ORAL
VIT K ANTAGONISTS
PROTEIN C
VITAMIN K ANTAGONISTS• COUMARIN DERIVATIVES- DICOUMAROL
• WARFARIN
• PHENINDIONE
VITAMIN K
• SOURCES:
Causes of deficiency• Obstructive jaundice• New born babies• c/c diarrhoea• Side effect of antibiotic
VITAMIN K
• II• VII• IX• X• PROTEIN C• PROTEIN S
HEPARIN
PARENTERAL- I V OR S/C
• COLD-5-10 0C
• HIRUDIN –leech-anti thrombin
• DEFIBRINATION SUBSTANCES
• Malaysian pit viper venom
Hemostatic drugs
• INHIBIT FIBRINOLYTIC SYSTEM
• COAGULATION SYSTEM
• CAPILLARY INTEGRITY
• VASOCONSTRICTORS
• WOUND SEALING AGENTS
INHIBIT FIBRINOLYTIC SYSTEM
• Eaca• Transexemic acid• aprotinin
COAGULATION SYSTEM
• vit k• Botropase
CAPILLARY INTEGRITY
• Ethamsylate adrenochrome• Vitamin c
VASOCONSTRICTORS
• Somatostatin• adrenaline
WOUND SEALING AGENTS
• feracrylum