ANTI-GRAVITY REGENERATING SERUM - Purelogicol€¦ · ANTI-GRAVITY REGENERATING SERUM 30ml •...

ANTI-GRAVITY REGENERATING SERUM 30ml

• Improves facial contours • Stimulates collagen and elastin• Antioxidant protection• Visibly diminishes wrinkles• Firms and nourishes

26 Age 54 - 75

2 x per day (60 days)4% IdeaLift

In vivo tests

IdeaLift™ Butylene Glycol, Aqua, Sorbitan Laurate, hydroxyethylcellulose, Acetyl Dipeptide-1 Cetyl Ester

FREE FROMParabensAlcoholArtificial perfumeArtificial colours

Table results: Anti-gravity, jowls and face contouring SKIN VISCO-ELASTICITY (measured by Aeroflexmeter®)

Results Cohesion Firmness Density Resistance Jowl surface Jaw line shape / Contouring effect

30 days -3.6 years +6.2% up to 24% +10% up to 32% +41.5% -4.7% up to -19% +5.3% up to +35%

60 days -4.4 years +7.8% up to 28% +9.2% up to 34% +43.6% -11.3% up to -21% +7.5% up to +29%

DIRECTIONSApply a thin layer daily to a cleansed face and neck.

SKIN SCIENCEGravity-control and micro-collagen peptides counteracts sagging skin by stimulating collagen production and boosting elastin synthesis.

The expert formulation also contains nano-vitamins F, A, C and E whose superior absorption properties improve their efficacy.

These clinically proven ingredients are balanced with pure natural botanicals for an effective formulation.

This silky serum contains gravity-control and micro-collagen peptides which help stimulate collagen and elastin synthesis to reduce wrinkles and improve facial contours. Soothing botanicals and powerful nano-vitamins F, A, C and E are absorbed deeply to promote a youthful, radiant glow.

Before After 1 monthSculpted face

contours

Less saggingskin

Lifted contours

Firmer skin

Pleasant texture

Want to continueapplication

0 20 40 60 80 100

Matrixyl®

Glycerin, Butylene Glycol, Aqua, Carbomer, Polysorbate, 20-Palmitoyl Pentapeptide 4

Table results: Matrixyl versus Vitamin C Matrixyl Vitamin C

Collagen Type I +117% +42%

Collagen Type IV +327% +229%

GAG Hyaluronic Acid +267% -

Before After

Ingredients (INCI): Aqua (Water), Ethylhexyl Methoxycinnamate, Squalane, Glycerin. Butylene Glycol, Tocopherol, Phenoxyethanol, Benzyl Alcohol, Carbomer, Serica (Silk), Simmondsia Chinensis (Jojoba) Seed Oil, Sorbitol, Cyclopentasiloxane, Ethylhexyl Palmitate, Propylene Glycol, Citrus Aurantium Dulcis (Orange) Oil, Citrus Nobilis (Mandarin Orange) Peel Oil, Ethoxydiglycol, Sodium Ascorbyl Phosphate, Chenopodium Quinoa Seed Extract, Carica Papaya (Papaya) Fruit Extract, Lecithin, Sorbitan Laurate, Faex Extract, Aloe Barbadensis Leaf Juice, Tocopheryl Acetate, Polysorbate 20, Silica Dimethyl Silylate, Glyceryl Linoleate, Glyceryl Linolenate, Caprlyl Glycol, Xanthan Gum, Retinyl Palmitate, Hyethylcellulose, Lactic Acid, Potassium Sorbate, Acetyl Dipeptide-1 Cetyl Ester, BHT, Sodium Benzoate, Limonene, Disodium Edta, Propylene Glycol Dicaprylate/Dicaprate, Sodium Hyaluronate, Glyceryl Caprylate, Palmitoyl Pentapeptide-3, Hexylene Glycol.

Copyright © Sederma.

Copyright © Sederma.

Untreated 3P editpePnoitcefreP %1obecalP

S-090 / © Mibelle AG Biochemistry 2011

Cellular adhesion scanned by electron microscopy

not treated placebo Perfection Peptide P3

TRIPLE HELIX COLLAGEN BOOSTING MASK 50ml

This rejuvenating tri-peptide mask contains purified micro-algae which work on three levels. It instantly firms, boosts collagen synthesis and helps strengthen the skin matrix. Potent antioxidants and nourishing botanicals acai, edelweiss and dragon fruit leave skin feeling soft and radiant.

DIRECTIONSApply a thin layer to a cleansed face and neck avoiding direct contact with eyes. Gently massage in an upward direction for 1 – 2 minutes. Leave on for 15 – 20 minutes before removing with lukewarm water or a damp muslin cloth.

SKIN SCIENCEPepha-tight’s micro-algae have an immediate firming effect on the skin. When applied long term, pepha-tight acts as a shield against oxidative stress and stimulates the formation of collagen I, an essential part of the skin’s connective tissue.

Our mask also contains perfection peptide which gently rejuvenates the skin and a combination of high quality nourishing botanicals, some of which contain high concentrations of vitamins, especially vitamin C.

• Visibly reduces fine lines & wrinkles• Activates skin cell regeneration• Visibly reduces hyperpigmentation• Boost collagen synthesis• Improves skin radiance

Perfection Peptide P3 Hexanoyl Dipeptide-3 Norleucine Acetate, Lecithin, Glycerin, Phenoxyethanol, Aqua

Placebo 1% PerfectionPeptide P3

Reduction compared to initial conditions and to untreated in %

–10 0 10 20 30 40

Median depthof furrows

Depth and numberof wrinkles

Results obtained with one volunteer (Age: 53)

Before

After 17 days

S-090 / ©Mibelle AG Biochemistry 2011

Placebo 1% PerfectionPeptide P3

Reduction compared to initial conditions and to untreated in %

–10 0 10 20 30 40

Median depthof furrows

Depth and numberof wrinkles

Results obtained with one volunteer (Age: 53)

Before

After 17 days

S-090 / ©Mibelle AG Biochemistry 2011

2 x per day (17 days)

1% P Peptide P3

In vivo tests Before After 17 days


Copyright © Mibelle AG Biochemistry

Pepha®-TightAlgae extract, Pullulan

FUNCTION:

3 in 1: PEPHA®-TIGHT works with short- middle -

and long-term effects:

1. Instantaneous: PEPHA®-TIGHT has a

noticeable instant tightening effect and smoothes

fine wrinkles

2. Prevention: PEPHA®-TIGHT acts preventively as

a protection shield against oxidative stress

3. Restoration: PEPHA®-TIGHT strengthens the

connective tissue by increasing the formation of

collagen I.

30 Age 54 - 75

2 x per day (14 days) 3% Pepha-Tight

In vitro tests

1. PEPHA®-TIGHT protects human fibroblasts from oxidative stress provoked by hydrogen peroxide.

2. PEPHA®-TIGHT stimulates the formation of collagen I in human fibroblasts.

In vivo test

1. The efficacy of PEPHA®-TIGHT was performed in an in vivo study with 30 volunteers applying a test gel containing 3% PEPHA®-TIGHT during 2 weeks. The figure shows the statements of the panellists reporting a very good/good tightening effect.

3. PEPHA®-TIGHT stimulates the proliferation of human skin fibroblasts in vitro.

PEPHA®-TIGHT [%]

PEPHA®-TIGHT [%] PEPHA®-TIGHT [%]

Ingredients: Aqua (water), Triheptanoin, Glyceryl Stearate, Cetearyl Alcohol, Stearic Acid, C10-30 Cholesterol/lanosterol Esters, Cera Alba (beeswax), Peg-100 Stearate, Glycerin, Triethanolamine, Phenoxyethanol, Pullulan, Adansonia Digitata Seed Oil, Cyclopentasiloxane, Xanthan Gum, Propylene Glycol, Citric Acid, Algae Extract, Tocopheryl Acetate, Disodium Edta, Calophyllum Inophyllum Seed Oil, Ethylhexylglycerin, Lecithin, Sodium Benzoate, Potassium Sorbate, Sorbitol, Trifolium Pratense (clover) Flower Extract, Sodium Ascorbyl Phosphate, Leontopodium Alpinum Flower/leaf Extract, Agave Tequilana Leaf Extract, Faex Extract, Lonicera Japonica (honeysuckle) Flower Extract, Hylocereus Undatus Fruit Extract, Glyceryl Linoleate, Glyceryl Linolenate, Retinyl Palmitate, Caprylyl Glycol, Tocopherol, Benzoic Acid, Ascorbic Acid, Euterpe Oleracea Fruit Extract, Glyceryl Capylate, Hexanoyl Dipeptide-3 Norleucine Acetate, Borago Officinalis Seed Oil.

Copyright © Pentapharm

SUPER ANTIOXIDANT MOISTURISER - SPF 15 50ml

An uplifting moisturiser infused with nano-vitamins, grape seed and green tea to help defend against free radical damage and photo-ageing. This innovative formula combines active peptides and proteins clinically proven to boost collagen synthesis; it visibly reduces wrinkles, rehydrates and nourishes for a more youthful complexion.

DIRECTIONSApply daily to a cleansed face and neck. Reapply as required.

SKIN SCIENCETrylagen peptide works to boost collagen, supported by pepha-protect which helps protect the skin’s DNA from free radicals.

The expert formulation also contains nano-vitamins F, A, C and E whose superior absorption properties improve their efficacy.

• Superior antioxidant protection• Deeply hydrates and nourishes• Visibly reduces wrinkle depth• Boosts collagen synthesis• Helps prevent DNA damage


Trylagen™ Aqua, Pseudoalteromonas Ferment Extract, Hydrolyzed Wheat Protein, Hydrolyzed Soy Protein, Tripeptide-10

Citrulline, Tripeptide-1, Lecithin, Xanthan Gum, Carbomer, Triethanolamine.

• Increase in Collagen type III synthesis Human Dermal Fibroblasts were treated with a mixture of

Hydrolysed soy protein (HSP) and Hydrolysed wheat protein (HWP) at two different concentrations. Collagen III was detected using an ELISA test monoclonal antibodies.

1. COLLAGEN BOOSTING

• Increase in Collagen types I and IV synthesis

A sample of a cream containing

1.25% pseudoalteromonas Ferment Extract was testing in reconstituted human skin.

20 Age 35 - 55

2 x per day (60 days)1% Trylagen

In vivo tests

Copyright © Lipotec

Anti-wrinkle

The depth of wrinkles was examined by means of the optical 3D measurement PRIMOS.

2. COLLAGEN ORGANISATION

•Dermal Collagen fibrils study Tissues from a tridimesional human skin model

were treated with Tripeptide-10 Citrulline 0.01%. Tissues were sectioned and then observed by Transmission Electron Microscopy.

0 days

Control Tripeptide-10 Citrulline

30 days

128% increase of Collagen I synthesis after 15 days.

Type I collagen fibrils have a great tensile strength and elastic resistance.

81% increase of Collagen IV synthesis after 15 days.

Type IV collagen is the most abundant structural component of basement membranes.

Collagen III production tripled at the highest dose.

Youthful skin contains a predominance of collagen III, but during the aging process, cells gradually lose their ability to produce this type of collagen.

Trylagen™ controls collagen fibril dimensions by uniformising their diameter and regular spacing.

This function provides a better cohesion and stabilisation of collagen fibres, and gives suppleness to the skin.

Ingredients: aqua (water), caprylic/capric triglyceride, butyl methoxydibenzoylmethane, polysilicone-15, ethylhexyl methoxycinnamate, glyceryl stearate, octocrylene, peg-100 stearate, cyclopentasiloxane, glycerin, cetearyl alcohol, prunus amygdalus dulcis (sweet almond) oil, phenoxyethanol, simmondsia chinensis (jojoba) seed oil, vitis vinifera (grape) seed oil, polysorbate 60, citrus aurantium sinensis peel extract, citrus medica limonum (lemon) leaf/peel/stem oil, ocimum basilicum (basil) flower/leaf extract, citrus aurantium bergamia (bergamot) leaf oil, elettaria cardamomum seed oil, juniperus mexicana oil, cupressus sempervirens oil, ferula galbaniflua (galbanum) resin oil, zingiber officinale root, 3-hexenol, citrus aurantifolia (lime) peel extract, citrus nobilis (mandarin orange) peel oil, myristica fragrans (nutmeg) extract, citrus aurantium amara, rosmarinus officinalis stem extract, salvia sclarea (clary) oil, camelia sinensis leaf extract, ammonium polyacryloyldimethyl taurate/vp copolymer, tocopheryl acetate, aloe barbadensis leaf juice, tocopherol, isopropyl palmitate, panthenol, pseudoalteromonas ferment extract, ethylhexylglycerin, fucus vesiculosus extract, sodium ascorbyl phosphate, sorbitol, faex extract, lecithin, citrullus lanatus (watermelon) fruit extract, hydrolyzed wheat protein, camellia sinensis leaf extract, isopropyl myristate, hydrolyzed soy protein, citrus aurantifolia (lime) oil, citrus aurantium dulcis (orange) oil, citrus medica limonum (lemon) peel oil, sodium hyaluronate, triethanolamine, caprylyl glycol, xanthan gum, glyceryl linoleate, glyceryl linolenate, butylene glycol, potassium sorbate, citrulline, retinyl palmitate, sodium benzoate, BHT, disodium EDTA, glyceryl caprylate, tripeptide-10 citrulline, carbomer, tripeptide-1, limonene, linalool, citral



CELLULAR RENEWAL FACE WASH 175ml

This luxurious foaming wash contains a rejuvenating AHA and enzyme complex to help stimulate cell-renewal. The skin-purifying formula decongests pores and targets uneven skin tone.

Enriched with skin-comforting liquorice and magnolia bark extract, it leaves skin feeling soft, supple and glowing.

DIRECTIONSUse once or twice daily. Dispense a small amount on to moistened hands and work into a creamy lather. Massage gently over wet face and neck. Rinse with lukewarm water and pat dry.

SKIN SCIENCEThe formula is the perfect balance between nature and science. AHA - Alpha-hydroxy acids help with fine lines, irregular pigmentation and age spots. Zymo Clear Enzyme boosts cell renewal.

Other pure, natural ingredients include a range of exotic plant extracts, carefully formulated to sooth the skin and improve hydration.

• Deeply cleanses & purifies• Stimulates cell renewal• Brightens & evens complexion• Visibly reduces fine lines •Improves skin tone & texture

MAXnolia Magnolia Officinalis Bark Extract (and) Vitis Vinifera / Vitis Vinifera (Grape) Seed Extract (and) Tocopherol (and) Lecithin (and)

Maltodextrin (and) Aqua / Water

20 Age 54 - 78

2 x per day (28 days)0.5% MAXnolia

In vivo tests

AHA Complex

Glycolic, Citric& Lactic Acid

Reduces pigmentation

Stimulates CellRenewal

Evens complexion


AquaCacteen - Opuntia Ficus-Indica Stem Extract,

Glycerin, Phenoxyethanol and Aqua/Water.

After 28 days of treatment, a reduction of skin redness could be detected in 85 % of the volunteers.

After 28 days of treatment, the improvement was observed in:

•90%ofthevolunteersforfirmness•100%ofthevolunteersforhydration•95%ofthevolunteersforTEWL.

1. Results showed that MAXnolia significantly reduced facial skin redness compared to the placebo.

2. Results showed that MAXnolia increased the skin elasticity of the crow’s feet and decreased the skin fatigue compared to the placebo.

3. Results showed that MAXnolia significantly in-creased skin hydration and firmness and decreased TEWL compared to the placebo..

Dec

reas

e in

red

ness

aft

er 2

8 d

ays

com

par

ed

to in

itial

con

diti

ons

in (%

)

Cha

nge

com

par

ed

to t

he in

itial

con

diti

ons

in (%

)

Cha

nge

com

par

ed

to t

he in

itial

con

diti

ons

in (%

)

* p<0.05 versus initial conditions

** p<0.05 versus initial conditions and placebo

* p<0.05 versus initial conditions

** p<0.05 versus initial conditions and placebo

Elasticity Skin Fatigue

Firmness Hydration TEWL

0.5% MAXnolia 0.5% MAXnolia

0.5% MAXnolia

Placebo Placebo

Placebo

*

-10.6%

**

**

**

**

+10.3%

*

*

*

0.0

-1.0

-2.0

-3.0

-4.0

-5.0

-6.0

8

4

0

-4

-8

40

30

20

10

0

-10

Ingredients: Aqua (water), Sodium Coco-sulfate, Cocamidopropyl Betaine, Polysorbate 20, Glycerin, Glycyrrhiza Glabra (licorice) Root Extract, Sodium Lauryl Glucose Carboxylate, Styrene/acrylates Copolymer, Benzophenone-3, Lauryl Glucoside, Phenoxyethanol, Benzyl Alcohol, Maltodextrin, Potassium Sorbate, Disodium Edta, Ocimum Basilicum (basil) Flower/leaf Extract, Citrus Aurantium Bergamia, Carum Carvi (caraway) Fruit Oil, Elettaria Cardamomum Seed Oil, Coriandrum Sativum (coriander) Seed Oil, Cupressus Sempervirens Oil, Lavandula Hybrida Oil, Citrus Medica Limonum (lemon) Leaf/peel/stem Oil, Citrus Aurantifolia (lime) Peel Extract, Myristica Fragrans (nutmeg) Extract, Citrus Aurantium Sinensis Peel Extract, Piper Nigrum (pepper) Fruit Oil, Rosmarinus Officinalis (rosemary) Flower/leaf/stem Extract, Camelia Sinensis Leaf Extract, , Thymus Vulgaris (thyme) Extract, Anthemis Nobilis Flower Extract, Glycolic Acid, Lactic Acid, Symphytum Officinale Rhizome/root Extract, Lecithin, Tocopherol, Lactobaccillus/pumpkin Fruit Ferment Filtrate, Citric Acid, Opuntia Ficus-indica Stem Extract, Subtilisin, Magnolia Officinalis Bark Extract, Vitis Vinifera (grape) Seed Extract, Lipase, Limonene, Citral, Linalool.

20 volunteers (14 days) treatment of 2% AquaCacteen

In vivo tests

Incr

ease

in fi

rmne

ss in

(%)

Day 14 Day 17

2% AquaCacteenPlacebo25

20

15

10

5

0

After a pre-treatment time of 2 weeks, a clear improvement in skin firmness could be measured.

The test site was then radiated with 1 MED. ThreeDays later, skin firmness reduced in the area treatedwith the Placebo, whereas firmness in the zone treated with AquaCacteen remained unchanged.

Other testing confirmed that AquaCacteen at 2% was found to protect skin against irritation and increased skin hydration.

Copyright © Mibelle AG Biochemistry

TRI-PEPTIDE DEEP CLEANSER 175ml

This light creamy cleanser incorporates an advanced tri-peptide which helps detoxify skin cells. It gently and effectively sweeps away impurities, make-up and bacteria while protecting natural skin lipids.

Pure botanicals chamomile, green tea and mineral-rich seaweed leave skin feeling beautifully soft, nourished and hydrated.

DIRECTIONSUse morning and evening. Gently massage one or two pumps over the entire face and neck. Remove with a cotton pad or damp muslin cloth.

SKIN SCIENCEA key ingredient of our tri-peptide cleanser is Prolixir S20, a newly launched dimer tri-peptide which has been developed to help detoxify skin.

This sophisticated active ingredient helps maintain the natural defences of aged skin cells by preserving Ub-P levels and decreasing senescence markers.



Prolixir S20Aqua (water), Butylene Glycol, Dimer Tripeptide-43

Normal human keratinocytes aged

Prolixir S20 at 1% (45 day culture)

Normal human keratinocytes aged

Prolixir S20 at 1% (15 day culture)

Evaluation: Western blotting of proteasome 20S and ubiquitinated proteins.

Evaluation: Fluorescence assay of Trypsin-like,Chymotrypsin-like, Peptidylglutamyl peptidehydrolase (PGPH) peptidase activites.

In vitro tests In vitro tests

Ub-proteins Proteasome 20S Trypsin-like Chymostrypsin-like PGPH

Ub-proteins and proteasome 20S

level in aged cells.

proteasome activity

in aged cells.

160 160180

+34% +30%+45%

+22%

+55%

140 140120 120

% o

f int

ensi

ty

% o

f act

ivity

100 10080 8060 6040 4020 20

0 0

Prolixir S20 Prolixir S20Control Control

Ingredients: Aqua (water), Ethylhexyl Palmitate, Glycerin, Candelilla/jojoba/rice Bran Polyglyceryl-3 Esters, Prunus Amygdalus Dulcis (sweet Almond) Oil, Olea Europaea (olive) Fruit Oil, Sclerotium Gum, Oleyl Alcohol, Isopropyl Palmitate, Glyceryl Stearate, Cetearyl Olivate, Benzyl Alcohol, Cetearyl Alcohol, Sorbitan Olivate, Camellia Sinensis Leaf Extract, Sodium Stearoyl Lactylate, Caprylic/capric Triglyceride, Butylene Glycol, Anthemis Nobilis Flower Extract, Fucus Vesiculosus Extract, Sodium Citrate, Chondrus Crispus (carrageenan) Extract, Aspalathus Linearis Extract, Aloe Barbadensis Leaf Juice, Bambusa Arundinacea Stem Powder, Tocopherol, Isopropyl Myristate, Dehydroacetic Acid,, Citrus Medica Limonum (lemon) Leaf/peel/stem Oil, Ocimum Basilicum (basil) Flower/leaf/extract, Citrus Aurantium Bergamia (bergamot) Leaf Oil, Elettaria Cardamomum Seed Oil, Juniperus Mexicana Oil, Cupressus Sempervirens Oil, Ferula Galbaniflua (galbanum) Resin Oil, Zingiber Officinale Root, 3-hexenol, Citrus Aurantifolia (lime) Peel Extract, Citrus Nobilis (mandarin Orange) Peel Oil, Myristica Fragrans (nutmeg) Extract, Citrus Aurantium Sinensis Peel Extract, Citrus Aurantium Amara , Rosmarinus Officinalis Stem Extract, Salvia Sclarea (clary) Oil, Citrus Aurantium Bergamia (bergamot) Fruit Oil, Phenoxyethanol, Potassium Sorbate, Faex Extract, Sodium Benzoate, Dimer Tripeptide-43, Limonene, Linalool, Citral

6mm of ex vivo human biopsies Prolixir S20 at 1% (48 hr culture)

Treatment: 24H -> UVB 100mJ/cm2 + Treatment 24H -> End (48H)Evaluation: Immunofluorescence staining of 20S proteasome and ubiquitinated proteinsQuantification: Image-Pro Analyzer software

Sun exposure is the major environmental influence for epidermal cells. The harmful effects of UV on skin is related to the generation of Reactive Oxygen Species which alter the cellular components, such as skin’s proteins.

Prolixir S20-treated skin exhibits higher level of ubiquitinated proteins and proteasome 20S after UV-irradiation, suggesting that Prolixir S20 may have a role in limiting UV-induced protein damage.

2D & 3D reconstruction of skin relief after application of Prolixir S20 cream from silicon replica measurement in-vivo.

Volunteer best result(Prolixir S20 cream vs placebo cream )

•Wrinklestotallength:-46.6%•Wrinklesnumber:-37.2%•Averagelengthcorrected:-46.6%•Averagedepthcorrected:-29%

Pro

lixir

S20

D23

| P

rolix

ir S

20 D

0

Cutaneous aging is associated with an accumulation of oxidized and covalently cross-linked proteins correlated with a decrease in proteasome activity.

Prolixir S20 helps fight against age-related decrease in Ub-P level and activity.

Aged cells treated with Prolixir S20 show increased levels of ubiquitinated proteins and proteasome S20. Likewise, the three peptidase activities of the proteasome: Trypsin-like, Chymotrypsin-like, Peptidylglutamyl peptide hydrolase are increased after Prolixir S20 application.

Ex vivo tests

12 Age 29 - 56

2 x per day (24 days)1% Prolixir S20 against Placebo.

In vivo tests

Copyright © Ashland Specialties

Copyright © Ashland Specialties

INTELLIGENT TONER 175ml

This intelligent toner contains Normaseb which balances the sebaceous function of oily, dry and combination skin. The cooling formula gently removes traces of cleanser, refines pores and helps restore the skin’s pH level.

Pomegranate extract energises skin cells while soothing botanicals chamomile and aloe vera leave skin feeling soft, hydrated and refreshed.

DIRECTIONSUse morning and evening after cleansing. Apply with a cotton pad and sweep gently over entire face and neck avoiding direct contact with eyes.

SKIN SCIENCENormaseb is an outstanding ingredient that works by balancing the sebaceous function of oily, dry and combination skin.

It has been expertly combined with Sea Starwort Oil, a marine plant extract which reinforces the skin’s barrier, and protects blood vessel membranes, reducing blotchiness and redness.



Normaseb Water(Aqua) (and) Hydrolyzed Milk Protein (and) Glycerin

14 volunteers - OILY SKIN

Normaseb at 3% (4 weeks against placebo)

24 volunteers - DRY SKIN

Normaseb at 3% (4 weeks against placebo)

Test Method: Sebutape Test Method: Sebutape

No significant difference in any parameters between 0 and 28 days where recorded with the Placebo.

In vivo tests In vivo tests

D0 D28 D0 D28 D0 D28D0 D28

Reduction of sebum

quantity: -50%

Increase in sebum

level: x 5

Reduction of active

glands: -29%

Increase of active

sebum glands: +124%

160180

140

6 3

120 5 2.5 100

100 4 2 80

80 3 1.5 60

60 2 1 4040

1 0.5 2020

0 0 0 0

Total Sebum (% de surface) Total SebumActive Glands Active Glands

Copyright © Sederma

PureLogicol International Ltd. 16 Hanover Square, Mayfair, London, W1S 1HT T + 44 (0)870 750 2401T + 44 (0)1563 541333 F + 44 (0)1563 541444 E [email protected] www.purelogicol.com

Ingredients: Aqua (water), Aloe Barbadensis Leaf Juice, Glycerin, Phenoxyethanol, Carbomer, Hydrolyzed Milk Protein, Ethylhexylglycerin, Propylene Glycol, Anthemis Nobilis Flower Extract, Cucumis Sativa (cucumber) Fruit Extract, Fucus Vesiculosus Extract, Caprylic/capric Triglyceride, Faex Extract, Punica Granatum Fruit Extract, Sodium Hyaluronate, Hamamelis Virginiana Leaf Extract, Aster Maritima Extract, Potassium Sorbate, Ascorbic Acid, Citric Acid, Sodium Hydroxide

20 Age 30 - 65

2 x per day (28 days)1% Sea Starwort Oil

In vivo testsTest Method: -Moisturising Measurment (CornemeterCM825R) -Self evaluation from a questioner -Visual scoring (Scaled from 1-10) -Spectro Photometric Measurement (Siascope II) of surface covered by micro-circulation network.

Surface covered by the micro circulation network per mm2

SEA STARWORT OIL® (1%) + UVBirradiation

UVB irradiation

Control

PGE2 release(pg/ml)

PGE2 variationin %Assay

SEA STARWORT OIL® reduces by 15% the surface covered by the microcirculation network

PGE2: first marker of blood vessel membrane disorders

SEA STARWORT OIL® decreases PGE2 release induced by UVB: protection of blood vessel membrane

Other testsProtocol: Human keratinocytes in cultureTest: PGE2 MeasurementUVB stress: 100mJ/cm2

1% of SEA STARWORT OIL® in culture medium.

In vivo skin redness results

SEA STARWORT OIL® increases face complexion homogeneity by 12% after 28 days

In vivo visual scoring results

Area Area

Treated area Skin firmness

No treated areaFace complexion

homogenity

Variation(in average)

D0

3.76 +/- 1.88

3.20 +/- 1.82

3.18 +/- 1.84

3.37 +/- 2.34

372 +/- 15 -

+ 45%

- 34%

539 +/- 21

358 +/- 24

-15.40%

+5.21%

4.30 +/- 1.53

4.05 +/- 1.82

4.60 +/- 1.43

4.44 +/- 1.47

+6.98%

+12.35%

D0 D28D28 - -

Variation(in average)

Visual scoring (Scale from 1 to 10)

Normaseb increases and decreases the sebum production simultaneously, but at different skin sites.

Normaseb balances combination skin.

D0 D28 D0 D28

Oily Skin Oil-def. Skin

300

250

200

150

100

50

0

Normalisation of Sebum

Oily Skin

Normal Zone

Oil Deficient Skin

Sea Starwort OilCaprilic/Capric triglyceride – Aster Maritima/Tripolium Extract

Copyright © Sederma

Copyright © Biotech Marine

Copyright © Biotech Marine

ANTI-GRAVITY REGENERATING SERUM - Purelogicol€¦ · ANTI-GRAVITY REGENERATING SERUM 30ml •...

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Transcript of ANTI-GRAVITY REGENERATING SERUM - Purelogicol€¦ · ANTI-GRAVITY REGENERATING SERUM 30ml •...