Anti arrhythmic drugs
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Transcript of Anti arrhythmic drugs
STEP TO PG-MD/MS - DR.AKIF A.B
ANTI-ARRHYTHMICS
STEP TO PG-MD/MS - DR.AKIF A.B
STEP TO PG-MD/MS - DR.AKIF A.B
Na+ channel blockage Decreases slope of Phase 0
K+ channel blockage Increases duration of action potential
K+ channel opener Decrease duration of action potential
STEP TO PG-MD/MS - DR.AKIF A.B
--- a) Na+ channel blockage
--- b) K+ channel blockage
--- c) K+ channel opener
a)
b)
c)
Phase 0Phase 2
Phase 1
Phase 3
Phase 4Phase 4
STEP TO PG-MD/MS - DR.AKIF A.B
NORMAL ECGAction potential difference = QT interval
K+ channel blockers
K+ channel blockage
Increases duration of action potential
K+ channel opener
Decrease duration of action potential
STEP TO PG-MD/MS - DR.AKIF A.B
Na+ channel = Depolarisation(QRS wave)
Na+ channel blockage = Increases QRS duration
K+ channel = Repolarisation(QT interval)
K+ channel Blockage = Prolongs QT interval
K+channel Opener = Shortens QT interval
STEP TO PG-MD/MS - DR.AKIF A.B
ANTI ARRHYTHMICSClass I Na+ channel blockerClass II Beta blockersClass III K+ channel blockerClass IV Calcium channel
blockerClass V Others
STEP TO PG-MD/MS - DR.AKIF A.B
CLASS-I ANTI ARRHYTHMICS
Ia Ib IcNa+ channel blockage
Na+ channel blockage
Na+ channel blockage
K+ Channel blockage K+ channel opener No effect on K+ channel
QuinidineProcainamide (S/E:SLE)
LignocainePhenytoinTocainide
Encainide FlecainidePropafenone
Queen – QuinidinePrincess - Procainamide
Used only for ventricular Arrhythmias
STEP TO PG-MD/MS - DR.AKIF A.B
STEP TO PG-MD/MS - DR.AKIF A.B
PROPRANOLOL
METOPROLOL
CLASS-II ANTI ARRHYTHMICS
BETA BLOCKERS
STEP TO PG-MD/MS - DR.AKIF A.B
CLASS-IIIANTI ARRHYTHMICSB – Bretylium
I – Ibutilide
N – No
D – Dofetilide
A – Amiodarone
S - Sotalol
STEP TO PG-MD/MS - DR.AKIF A.B
AMIODARONE-Metabolised by microsomal enzymes
-Have all the 4 mechanisms : Na+ #
K+ #
Beta #
Ca #
-Longest acting (T1/2 = >3wks)
-Used for all Arrhytmias except Torsades De pointes ( Since it prolongs QT interval)
-
STEP TO PG-MD/MS - DR.AKIF A.B
AMIODARONES/E
The = Thyroid (Hypo or Hyper)
Periphery of = Peripheral Neuropathy
My = Myocardial Depression
Lung & = Lung fibrosis
Cornea is = Corneal deposits
Photosensitive = Photosensitivity
STEP TO PG-MD/MS - DR.AKIF A.B
AMIODARONES/E
STEP TO PG-MD/MS - DR.AKIF A.B
CLASS-IVANTI ARRHYTHMICS
Calcium Channel Blockers
-Verapamil
-Diltiazem
- Dipines do not act on heart.
STEP TO PG-MD/MS - DR.AKIF A.B
CLASS-V ANTI ARRHYTHMICS
Digitalis DOC for Atrial fibrillation + CHF
Atropine Used for Bradyarrhythmias
- DOC for AV blockAdenosine Shortest acting Anti-
Arrhythmias (T1/2 < 10sec)
- DOC for PSVTMgSO4 DOC for Torsades De
Pointes
STEP TO PG-MD/MS - DR.AKIF A.B
DOCAtrial fibrillation and flutter -Acute attack = I.V Ibutilide
-Rhythm control = Amiodarone
-Rate control = Beta blockersAnticoagulation in Atrial Fibrillation
Noval Oral Anticoagulants-Dabigatran-Apixaban
PSVT Treatment = I.V Adenosine
Prophylaxis = Verapamil or Beta Blockers
SVT Treatment and Prophylaxis = Verapamil> Beta blockers
- Associated with CHF = Digoxin
STEP TO PG-MD/MS - DR.AKIF A.B
DOCTorsades De Pointes Magnesium sulphate
Ventricular extrasystole Beta Blockers
Ventricular fibrillation Amiodarone
Digitoxin Toxicity Lidocaine
Ventricular Tachycardia in M.I Lidocaine
WPW Sx Procainamide
STEP TO PG-MD/MS - DR.AKIF A.B
STEP TO PG-MD/MS - DR.AKIF A.B