1

Annualreport2017

Women’sHealthandPerinatologyResearchGroup(ForskningsguppeKvinnehelseogperinatologi),DepartmentofClinicalMedicine,FacultyofHealthSciences,UiT

TheArcticUniversityofNorway,TromsøIntroductionWomen’sHealthandPerinatologyResearchGrouphasbeenworkingactivelyinresearchandeducationsinceitsestablishmentin2009withtheaimofenhancinghealthandwellbeingofwomenandbabies.Wefocusonclinical,basicandtranslationalresearchaswellasepidemiologicalstudiesrelatedtoobstetrics,maternal-fetalmedicine,perinatalmedicineandfemaleincontinence.MembersoftheresearchgroupandcollaboratorsPermanentstaff

• GaneshAcharya,leaderandprofessor(20%),currentlyonleavefromhis100%positionandworkingatKarolinskaInstitute

• PålØian,actingleaderfrom1.7.2015,professor(20%)• PurusotamBasnet,professor(20%)• ÅseVårtun,technicalstaff,senioringeniør(100%)

Otherstaff

• FrancescoD’Antonio,associateprofessor(100%)• ÅshildBjørneremassociateprofessor(50%)until01.08.16,then70%and30%researcher• EliseSletten,clinicallecturer(50%)until01.08.17• IngardNilsen,assistantprofessor(20%)• AnneBeateVereide,associateprofessor(20%).SheisemployedattheDepartmentofClinical

Medicine-ObstetricsandGynecology,butisassociatedwithGynecologicalOncologyResearchgroupattheDepartmentofMedicalBiology

• ØysteinPedersen,clinicallecturer(20%)from01.08.17• KariFlo,associateprofessor(10%)• AnneHansson,clinicallecturer(10%)from01.08.17

PhDcandidates

1. ChristianWidnes(nofundingin2017,UNN)2. ElisabethLudvigsen(50%)externalfunding,Helse-Nord3. MonaNystad(nofunding)in2017,dissertaionplannedon11May20184. MadhuWagle(nofunding)5. QiongjieZhou(50%)externalfunding,FudanUniversity,Shanghai,China.6. TonjeLippert(nofunding)in20177. SivBoonMundal(100%)supportedbyNTNU,Trondheim8. LottaHerling(partlyfunded)byHelseNord,dissertationplannedinKarolinskaInstituteon6April

20189. AmarnathBhide(50%)externalfundingbySt.GeorgesHospital,LondonuntilAugust2017.

DefendedthesisinAugust2017

2

10. PriyaBhide(50%)externalfundingbyHommertonHospital,London11. SigneEgenberg(100%)externalfunding,Lærdalfondet.DissertationMay15,2017.12. AneSigridNygaard(100%)externalfunding,Fysiofondet/HelseNord,maternityleaveuntilApril

201813. DariyaPopova(100%)externalfunding,UiTstrategicgrant201614. MaritOsima(100%)internalfunding–EpiNorresearchschool15. RitaKral(100%)externalfundingfromHelseNordDec201616. CamillaAndreasen(100%)externalfundingHELSEFORSK17. ToveTveitanBorgen(100%)externalfundingHELSEFORSK18. HanneFrøyshov(nofunding),employedatHelse-Nord

Postdoc.Candidate

• MayWencheJøraholmen(100%)externalfunding,HelseNord

PhDdegreeawards1. AmarnathBhide(2017).Thesistitle:EffectofHypoxiaonfetalcardiacfunction.UiT.TheArctic

universityofNorway.01.08.2017.Principalsupervisor:GaneshAcharya.Co-supervisor:JuhaRäsänen

2. SigneEgenberg(2017).Thesistitle:Multi-professionalsimulationtrainingonpostpartumhemorrhageinTanzaniaandNorway.15.05.2017.Principalsupervisor:LarsEdvinBru.Co-supervisor:PålØian

Localcollaboration• NatasaSkalko-Basnet,DrugTransportandDeliveryResearchGroup,IFA,UiT• AnneHusebekk,BjørnSkogenandHeidiTiller,ImmunologyResearchGroup,IMB,UiT• KirstiYtrehus,CardiovascularResearchGroup,IMB,UiT• ToreSørlie,PsychiatryResearchGroup,IKM,UiT• HenrikSchirmer,DepartmentofHeartMedicine,UNN• TrondFlægstad,PerIvarKaaresenandClausKlingenberg,PediatricResearchGroup,UiT• TomWilsgaard,ISM,UiT• GunnarLeivseth,IKM,UiT• EllisivMathiesenandSteinHaraldJohnsen,BrainandCirculationResearchGroup• TerkelHanssen,IFA,UiT• BalpreetAhluwalia,DepartmentofPhysics,UiT• LottaHalvorsen,UNN• HildeNerum,UNN• InigoMartinez,UiT• RagnarMartinJoakimsen,DepartmentofMedicine,UNN• ElinRichardsen,DepartmentofPathology,UNN• GunnarKnutsen,DepartmentofOrthopaedicSurgery,UNN• MaritWaaseth,DepartmentofPharmacy,UiT• AnneEliseEggen,DepartmentofCommunityMedicine,UiT• LarsMariusYtrebø,OPINklinikken,UNNogUiT

3

Nationalcollaboration

• VasilisSitras,OUS,Oslo• RolfGunnarJørstad,Norskpasientskadeerstatning(TheNorwegianSystemofCompensationto

Patients)• LarsTJohansen,Statenshelsetilsyn(TheNorwegianBoardofHealthSupervision)• SigneEgenberg,StavangerUniversitetssykehus• Ann-CharlotteIversen,Instituttforkreftforskningogmolekylærmedisin,Detmedisinskefakultet,

Norgesteknisknaturvitenskapeligeuniversitet(NTNU)Trondheim• MonaStedenfeldt,St.OlavsHospitalandNasjonaltKompetansesenterforinkontinensog

bekkenbunnsykdom(NorwegianNationalAdvisoryUnitonIncontinenceandPelvicFloorHealth)• EllenBlix,HøyskoleniOslo&Akershus• StineBernitz,HøyskoleniOslo&Akershus• TorbjørnEggebø,NTNUogNasjonaltsenterforfostermedisin,St.OlavsHospital.• LarsEdvinBru,UiS• ToneKristinOmslandUiO• ErikFinkEriksen,FredeFrihagen,LarsNordslettenogLeneBSolberg,UiOandOUS• TorbjørnWisløff,UiOandFHI• WenderFigved,Bærumsykehus• ToveTveitanBorgen,Drammensykehus• Jan-ErikGjertsenogEllenApalset,UiBogHaukelandsykehus• TrudeBasso,NTNUogSt.OlavsHospital• GunnhildHagen,FHI

Internationalcollaboration• JuhaRäsänen,OregonHealthandScienceUniversity,Portland,USAandUniversityofHelsinki,

Finland• TiinaErkinaro,OuluUniversityHospital,Oulu,Finland• RoyHomburg,LondonUK• AnthonyOdibo,UniversityofSouthFlorida,USA• AgataWloch,MedicalUniversityofSilesia,Katowice,Poland• AndresSalumets,UniversityofTartu,Estonia• MagnusWestgrenandSven-ErikSonesson,KarolinskaInstitutet,Stockholm,Sweden• JimZhang,XinhuaHospital,ShanghaiJiatongUniversitySchoolofMedicineShanhai,Chinaand

NationalInstituteofHealth;Bethesda,USA• XiaotianLi,FudanUniversity,Shanghai,China• JoukoPirhonen,Finland• MikeRobson,NationalMaternityHospital,Dublin,Ireland• MinhBui,JohnLHopper,andSusanPWalker,UniversityofMelbourne,Australia• StephenHodges,RoyalVeterinaryCollege,London,UK• B.Thilaganathan:FetalMedicineUnit,DivisionofDevelopmentalSciences,St.George’sUniversity

ofLondon,London• A.Bhide:FetalMedicineUnit,DivisionofDevelopmentalSciences,St.George’sUniversityof

London,London

4

• A.Khalil:FetalMedicineUnit,DivisionofDevelopmentalSciences,St.George’sUniversityofLondon,London

• A.Papagheorghiou:FetalMedicineUnit,DivisionofDevelopmentalSciences,St.George’sUniversityofLondon,London

• C.Garel:Hôpitald'EnfantsArmand-Trousseau-ServicedeRadiologie,26-28AvenueduDocteurArnoldNetter,Cedex12,Paris,France,75571

• ML.Moutard:ServicedeNeuropédiatrie,HôpitalTrousseau,HôpitauxUniversitairesdel'EstParisien,UniversitéPierreetMarieCurie,Paris,France

• G.Pilu:DepartmentofObstetricsandGynecology,Sant'Orsola-MalpighiHospital,UniversityofBologna,Bologna,Italy

• G.Rizzo:DepartmentofObstetricsandGynecology,UniversitàdiRoma,TorVergata,Roma,Italy• T.Lerman-Sagie:FetalNeurologyClinicandPaediatricNeurologyUnit,WolfsonMedicalCenter,

Holon,SacklerSchoolofMedicine,Tel-AvivUniversity,Tel-Aviv,Israel• G.Malinger:FetalNeurologyClinicandPaediatricNeurologyUnit,WolfsonMedicalCenter,Holon,

SacklerSchoolofMedicine,Tel-AvivUniversity,Tel-Aviv,Israel• L.ManzoliDepartmentofMedicineandAgingSciences,UniversityofChieti-Pescara,Italy;EMISAC,

CeSIBiotech,Chieti,Italy• RolfSchybertandRegineSusse,DepartmentofPharmacy,UniversityofFreiburg,Germany. • A.Odibo:DivisionofMaternalFetalMedicine,DepartmentofObstetricsandGynecology,Morsani

CollegeofMedicine,UniversityofSouthFlorida,Tampa,FL,USA.• P.Lim:DepartmentofRadiology,AbingtonHospital,Abington,PA,USA• K.Hack:DepartmentofGynaecologyandObstetrics,Diakonessenhuis,3582KEUtrecht,Netherlands• DilipMehata,IndianInstituteofTechnology.NewDehli,India

EducationThenumberofmedicalstudentshasbeenincreasingoveryearsbutnotcompensatedforbyanincreaseinthestaff.Teachinginobstetricsandgynecologyisdemandingespeciallysincebed-sideteachingmustbegiveninaone-to-onebasis(intheobstetricout-patientclinic,thegynecologicalout-patientclinic,thelaborward,gynecologicalandgyn-oncologyunits,andintheoperationtheater)ratherthantogroupsofstudents.Teachinginobstetricsandgynecologyisgivenintheinternationalsemester(4thyearofthemedicalstudy),with30-40internatioanalstudents,thusallteachingisinEnglish.Teachingisalsogiventothe6thyearmedicalstudents.Intheinternationalsemester,theteachinginclinicalskillsandsimulationstraining(Sim-Mom)iscondensedtotwoweeksattheskillslab.ThemainpersonresponsibleisourEnglishcolleagueHelenBintley.

MedicalstudentsatMED-3501(5.year’smedicalstudents)hasclinicalpracticeatUNN.Everystudentaregiven2weeksofclinicalpracticesandtraininginobstetricsandgynecologyattheDepartmentofObstetricsandGynecology.Sinceautumn2017,wehaveincreasedthenumberofSeminarsforthe6thyearmedicalstudentslightly,

5

andwehaveintroduced“Test-Exams”foreachof6thyearstudentsinaonetoonepatientsetting,followedbyexamquestionsingroups.Thishasbeenverypopularamongthestudents.

Sinceautumn2016,wehaveofferedincreasingnumberandlongersessions(upto3hours)withclinicaltrainingattheout-patientclinicsforthe4thyearmedicalstudent.Itisnowcompulsorytoperformatleast1pelvicexaminationand1examinationofapregnantwoman.Theclinicalstaffatourdepartmenthasbeenverysupportive,providingmoreextensiveclinicaltrainingof4th,5thand6thyearstudents.

Thestaffisalsoinvolvedassupervisorsandmentorsformasterstudentsandinexamcommittees.Digitalexamhasbeenintroduced,andwehavebeentroughatrainingprocessusingWiseflowandmakingMCQ.

ResearchResearchfocus

• Fetalphysiologyandperinatalmedicine• Basicandtranslationalresearchinperinatologyusinganimalmodels• Pregnancyandmaternalmentalhealth• Reproductiveandperinatalepidemiology• Preeclampsiaanditslong-termconsequences• Placentalbiologyincludinggenomicsandproteomics• Reproductiveendocrionology,preimplantationbiologyandclinicalassistedreproduction

technology• Femaleincontinenceandpelvicphysiology• Gestationaldiabetes• Bonefragility• Secondaryfractureprevention

InternationalprojectsProjectleader Collaborator Researchtitle FundedbyJuhaRäsänenUniversityofOulu,Oulu,Finland

GaneshAcharya

Experimentalstudiesonfetalcardio-vascularfunctioninasheepmodel

SigridJuseliusFoundationandUniversityHospitalofOulu,Finland

BalpreetAhluwalia,DepartmentofPhysics,UiT

PurusotamBasnet

SubcellularanatomyoflivecellsusingNanoscopyincollabotationwiththeteamofprofDilipMehata,IIT,NewDehli,India

NFR,Norway

Post-doctoralresearchprojectsPostdocresearchers Collaborator ResearchtitleStineBernitz PålØian Labourprogressionstudy(LaPS)MayWencheJøraholmen

PurusotamBasnet,GaneshAcharya

Targetedtherapyofgenitalchlamydiainfections:actinglocally,efficientlyandpatient-friendly

6

PhDresearchprojectsPhDresearcher Mainsupervisorsandco-

supervisorsProjecttitle Funding

ChristianWidnes

GaneshAcharya(principalsupervisor);KariFloandAnneHusebekk(co-supervisor),IMB

Maternalendothelialfunctionandfeto-maternalhemodynamicsinnormalandcomplicatedpregnancies:Anobservationalstudy

UNN

MonaNystad GaneshAcharya(principalsupervisor);VasilisSitras(co-supervisor)OsloUniversityHospital

Investigationintosomegeneticaspectsofpreeclampsia:RoleofLaeverininthepathophysiologyofpreeclampsiaandgenomecopynumbervariationinmaternalanumbilicalcordblood

HelseNord

MadhuWagle GaneshAcharya(principalsupervisor);PurusotamBasnet(co-supervisor)

SelfreportedoralhealthawarenessandattitudetowardsdentalcareandriskofdentalcariesamongpregnantwomaninNorway

None

QiongjieZhou GaneshAcharya(Principalsupervisor);XiaotianLi(co-supervisor)

EpidemilogicalmapofTORCHinfectionsinthepreconceptionperiodamongwomenofreproductiveageinruralChina:Apopulation-basednationwidestudy

FudanUniversity

MaritOsima

ÅshildBjørnerem(principalsupervisor),ErikFinkEriksen(co-supervisor,UiO)

Whydosomewomenbreaktheirboneswhileothersdonot?TheTromsøStudy

UiTInternFinansieringEpiNor

RitaKral

ÅshildBjørnerem(principalsupervisor),ElinRichardsen(co-supervisor,UiT)

Whydosomewomenbreaktheirboneswhileothersdonot?TheTromsøStudy(submittedthesis)

UNNHelseNord

CamillaAndreasen

ÅshildBjørnerem(principalsupervisor),ToneKOmsland(co-supervisor,UiO)

NoFRACT-NorwegianCapturetheFractureInitiative(ongoing)

HELSE-FORSKNFR-utlysning

ToveTveitanBorgen

ÅshildBjørnerem(Projectleaderandco-supervisor),ErikFinkEriksen(principalsupervisor,UiO)

NoFRACT-NorwegianCapturetheFractureInitiative(ongoing)

HELSE-FORSKNFR-utlysning

HanneFrøydhov

ÅshildBjørnerem(co-supervisor)TorgeirEngstad(principalsupervisor),DagSHalvorsen(co-supervisor)

Hjerneslag,risikofaktorerogprognose.HelseNordogHelseMidt.

None

TonjeLippert PålØian(principalsupervisor)

Birthoutcomeaccordingtoriskstatusatadmissioninbirthandchangesinriskstatusduringlabour

SykehusetAskerogBærum

SigneEgenberg E.Bru(principalsupervisor)PålØianandTorbjørnEggebø(co-supervisor)

Simulationtraininginobstetricswithfocusonseverebleeding

Lærdal-fondet

AneS.Nygaard PålØian(principalsupervisor);GroKHaugstad

Groupbasedsomatocognitivephysiotherapyforwomenwithchronic

FysiofondetHelseNord

7

Masterlevelresearchprojects

andMonaStedenfeldt(co-supervisors)

pelvicpain.Arandomizedcontrolledtrial.

ElisabethLudvigsen

Finn-EgilSkjeldestad(principalsupervisor)

Fødselsrelaterturininkontinensogprolaps(FRURIPRO)

Helse-Nord

SivBoonMundal

Ann-CharlotteIversen(principalsupervisor),NTNU,GaneshAcharya(co-supervisor)

Oxidativestressinplacentaldecudiaamongpreeclamticwomen

NTNU

DariyaPopova PurusotamBasnet(principalsupervisor);GaneshAcharyaandBalpreetAhluwalia(co-supervisors)

SubcellularanatomyofpreimplantionhumanembryousingNanoscopyTecnology.(astrategicgrantapprovedbyUiTandstartedfrom2016)

UiT

RebeckaDalbye

EllenBlix(principalsupervisor)PålØian(co-supervisor)

Laborprogressionstudy(LaPS).Aclusterrandomizedstudyin14obstetricdepartments

SykehusetØstfold

LottaHerling MagnusWestgren(principalsupervisor),GaneshAcharya,PeterLindgren,Sven-ErikSonesson(co-supervisors)

FunctionalstudiesofhumanfetalheartwithtissueDopplerimaging

KarolinskaInstitutet

EliseSletten(50%)

AnneØrbo(principalsupervisor);AnneBeateVereide(co-supervisor)

Significanceofprogestogentherapyinendometrialproliferativeconditions

UiT

PriyaBhide GaneshAcharya(principalsupervisor);RoyHomburg(co-supervisor)

Roleofovarianreservemarkersinfertilitymanagement

UiT

Masterstudent Supervisors Researchtitle

KristineTrovikFlaatten TorvidKiserud(principalsupervisor),GaneshAcharya(co-supervisor)

GynecologicalfistulasinNorway:Incidenceandmanagementoutcomes

MSc2017(completed)UiTMedicine

KarenLundTaranger PålØian Traumaticheadinjuriesafteroperativevaginaldeliveriesandcesareansections

MSc2017(completed)UiTMedicine

MariHansen ØysteinPedersen BehandlingavekstrauterintsvangerskapvedUNN,2006-2016

MSc(ongoing)UiTMedicine

EliseMarieSchneider PålØian Shoulderdystocia MSc(2017)(completed)UiTMedicine

8

OngoingprojectsGaneshAcharyaHisresearchactivitymainlyfocusesontheinvestigationoffetalandmaternalcardiovascularchangesinphysiologicalandpathologicalpregnancies.Thefocusisonthetranslationalaspectutilizingexperimentalanimalmodelsaswellasclinicalmaterialandepidemiologicaldatainourresearch.Someoftheongoingprojectsareoutlinedbelow.

• Experimentalstudiesonmaternalandfetalcardio-vascularfunctionusinganimalmodelsThisisanongoingcollaborationwithProfJuhaRäsänen(UniversityofHelsinki,Finland),OregonHealthSciencesUniversity,Portland,USAandUniversityofOulu,Finlandformorethan14years.Currentlyweareconductingexperimentsonfetalsheeptostudyfetalcardiovascularfunctionandmyocardialremodellingunderdifferentloadingconditionsusingconventionalechocardiography,myocardialtissue

FrankKwameNtiamoah ÅshildBjørnerem(co-supervisor),MaritWaaseth(mainsupervisor),AnneEliseEggen(co-supervisor)

Useofanti-osteoporoticdrugintheTromsøstudy.Isundertreatmentaproblem?

FAR-3911MasterofPharmacy,IFA.2016(completed)

NikitaBaiju RigmorBerg(mainsupervisor)GaneshAcharya(co-supervisor)

Self-assessmentoftheoutcomeoffirsttimestermedicalabortioncomparedtoClinicalfollowup:Asystematicreview

MasterofPublicHealth,ISM(ongoing)

MahmoodFouad ÅshildBjørnerem(co-supervisor),MaritWaaseth(mainsupervisor),AnneEliseEggen(co-supervisor)

Asssociationbetweenqualityoflifeanduseofanti-osteoporosisdrug

FAR-3911MasterofPharmacy,IFAUiT,May2017(completed)

SireMarrable ÅshildBjørnerem(mainsupervisor),BodilHvingel(co-supervisor)

Utviklingstrendiforekomstavdiabetesblantgravide,ogforekomstavpreeklampsiblantgravidemeddiabetes

MED-3950Master,5.-årsopp-gave,UiT,June2017.(completed)

MartineU.Glasø ÅshildBjørnerem(mainsupervisor),CamillaAndreasen(co-supervisor)

Forekomstavkomplikasjonerhosgravidemedogutendiabetes

MED-3950Master,5.-årsopp-gave.UiT(ongoing)

VeronicaG.Rognli ÅshildBjørnerem(mainsupervisor),MaritOsima(co-supervisor)

Behandlingogoppfølgingavbrudd-pasientermedbeinskjørhetvedUNN

MED-3950Master,5.-årsopp-gave.UiT(ongoing)

9

Dopplerimaging,ultrasonicflowprobesandpressurevolumeconductancecathetersinvivo.Wearealsostudyingthedifferencesinphysiologicalandpathologicalcardiacremodellinginpregnancyandeffectofavarietyofinterventions,suchasincreasedmaternalbloodpressure,high-intensityexercise,aortabindingetc,onthematernalheartandfeto-placentaldevelopmentusingpregnantrats.Wearealsoinvestigatingthefeasibilityofapplyingnewechocardiographictechniquessuchascolourtissuevelocityimagingindiagnosingfetalhypoxemia/acidemia.Wearetestingthepossibilityofusingcertainpharmaceuticalpreparationstoincreasefetalleftventricularpreloadbyimprovingfetalpulmonarybloodflow,whichmaybeusefulinpreventing/amelioratingcerebralhypoxemiainintrauterinegrowthrestrictedfetuses.

• Geneticandmolecularmarkersoffeto-maternaldiseasesWehavebeenstudyingplacentalgenomicsandcharacteristicsofhumantrophoblast(freshaswellascultured)usingadvancedcytogeneticandmolecularbiologymethods,suchasarray-CGH,PCR,microarrays,cellmigrationandinvasionassays,immunohistochemisty,electronmicroscopyetc.Wehavestudiedgeneexpressioninnormal,preeclampticandIUGRplacentas.Recentlywehaveidentifiedsomenovelimprintedgenesinplacenta.Wearealsoattemptingtoidentify,characterizeandclinicallyvalidatenovelmarkersofpreeclampsia.AmembraneboundplacentaspecificaminopeptidaseLaeverinisoneofsuchmarkerswearecurrentlystudying.

• Noninvasiveassessmentofcardiacfunctionandsystemicbloodflowinhumanfetuses:AnobservationalstudyThisprojectisconductedincollaborationwithKarolinskaInstitutet,KarolinskaUniversityHospitalandRoyalTechnicalInstitute,Stockholm.Inthisprojectweplantoestablishlongitudinalreferencerangesfortheparametersofheartfunctionmeasuredusingtissuevelocityimaging(thispartofthestudyisperformedinTromsø),applythistechniquetoidentifyfetusesatriskofcomplicationduetohypoxemia(IUGR,postdatepregnancy)andvolume-overload(anemiaduetoredcellalloimmunization,twin-twintransfusionsyndrome),anddevelopanautomaticandeasywayofmeasuringrelevantparametersincollaborationwithengineersattheRoyalTechnicalInstitute.

• Maternal-fetalhemodynamics,endothelialfunctionandplacentalbloodflowThisisanongoinglargestudyevaluatingmaternalhemodynamicsandendothelialfunctiontogetherwithseveralbiomarkerstoidentifywomenatriskofpregnancycomplications.Placentalandfetalbloodflowisalsosimultaneouslyinvestigated.Wearealsostudingsexdiffrencesinfetalplacentalbloodflowusingdatacollectedinthisstudyandpreviousstudies.Abiobankofbloodsamplesandplacentalsampleshavebeencollectedfromapproximately700participants.

• Long-termhealthandwellbeingofwomenwithaprevioushistoryofpre-eclampsiaInthisprojectweutilizethedatafromalargelongitudinalpopulationbased-surveyofTromsømunicipalitywhichhasbeenongoingfor>40years.Ourmainfocushasbeencardiovascularhealthofwomenwithprevioushistoryofpreeclampsia.TheprojectisconductedincollaborationbetweenourresearchgroupandtheInstituteofCommunityMedicine,UniversityofTromsø.

• Longitudinalchangesinoralmicrobialmilieuinnormalpregnancyandpregnancyoutcomes

10

Oralhealthinpregnancyisaneglectedareaofresearch.InthisstudyincollaborationwiththeInstituteofOdontologyinTromsøweareinvestigatingthelongitudinalchangesinoralmicrobialmilljoduringpregnancyandtheirrelationwithpregnancyoutcomes.

• Newnano-drugdeliverysystemsforthetreatmentofvaginalinfectionsIncollaborationwiththe“Drug-Delivery”ResearchgroupattheDepartmentofPharmacy,wearedevelopingnewliposome-basednanodrugformulationsforlocaldeliveryofintimicrobialsandantiinfammatoryagentstothegenitaltract.OnePhDthesishasbeencompletedrecentlyandonepostdoctorialprojecthasbeenjuststarted.ThepostdoctorialcandidatewillspendoneyearatKarolinskaInstitutet.

• ImpactoffreepreconceptioncareinruralChinaIncollaborationwithFudanUniversity,Shangahi,China,weareutilizingaverylargenationaldatasetcollectedduringtheimplimentaionofNationalFreePreconceptionHealthCareProjectinChinainselectedruralcountiesandsomemunicipalitiescoveringall31provincesinthecountrytostudypreconceptionriskfactors,vaccinationstatusprevalenceofTORCHinfectionsandimpactoffreepreconceptioncareonpregnancyoutcomes.OnePhDstudentfinancedbyFudanUniversityisregisteredatUiT.

PålØianInadditiontoongoingPh.Dprojects:• Obstericanalsphinctertears

AprojectwithnationaldatafromFinlandandNorway.Theprojectgroup:JoukoPirhonen,MikaGissler,MonaStedenfeldtandPålØian.

• ObstetricanalsphinctertearsinbreechdeliveriesAprojectwithdatafromMBRNfromtheperiod1994-2013.Theprojectgroup:Monastedenfeldt,TomWilsgaard,GaneshAcharyaandPålØian.

• MechanicalinjuriesaftervaginaldeliveriesAprojectwithdatafromMBRN.Focusisonmechanicalinjurieslikeskullfractures,intracranialbleeding,medullaspinalisinjuries,plexusbracialisinjuriesandotherfractures.Projectgroup:MonaStedenfeldt,GaneshAcharyaandPålØian.

• MaternaldeathinNorwayThisisanationalprojectonmaternaldeathfromthelast20yearsandup-datedeveryyear,alsoincollaborationwithotherScandinaviancountries.ProjectleaderSiriVangen,TheNationalHospital,Rikshospitalet,Oslo.CollaboratorPålØianandTheNorwegianAuditGrouponmaternalDeath.

• ClaimsinObstericsandGynecology–NorwegianBoardofHealthSupervision(Statenshelsetilsyn)ProjectleaderPålØiancollaboratingwithLarsT.Johansen,GeirSverreBrautandMikeRobson.

• Laborprogressionstudy(LaPSstudy)Thisisacluster-randomizedstudyin14Norwegianhospitalstestingouttwodifferentpartograms.In

11

NorwayandmostothercountriestheFriedman’spartogramforlaborprogressionhasbeenused.ContemporaryresearchbyZhangshowsthatthedilatationofthecervixcanbesubstantiallydifferent,especiallyintheearlystageoflaborandanewpartigramisdeveloped.Thetypeofpartogramusedisimportantforthediagnosisoflabordystocia.Inthisstudymorethan70000womenareincludedandtheinclusionprocessstopped31.jan2017.Theprimaryoutcomeiscesareansection.Secondaryoutcomesareindicationsforcesareansection,therateofoxytocinaugmentation,totaldurationofaugmentation,durationoflabor(firstandsecondstage),rateofdystocia,operativevaginaldeliveries,bleeding>500ml,Apgarscore≤7at5minutes,metabolicacidosis,transfertoNICUandwomen’sexperiencewithbirthcare.Dataarenowbeinganalyzed.Projectgroup:StineBernitz,EllenBlix,RebeckaDahlbye,JimZhang,TorbjørnEggebøandPålØian

• HomebirthinNorway,Sweden,DenmarkandIcelandProjectleaderEllenBlixcollaboratingwithPålØian,HelenaLindgren,OlofAstaOlafsdottir,HanneKHegaardandMereteKumle.

• NormalbirthinanepidemiologicalandclinicalperspectiveProjectleaderEllenBlix.CollaborationwithPålØian

• Mentalhealthandlabor

Theseprojectsarefollow-upstudiesbasedonthePhDprojectsofHildeNerumandLottaHalvorsen.Projectgroup:HildeNerum,LottaHalvorsen,ToreSørlie,BjørnStraume,PålØianogprofessorIngegerdHildingsson,Mitt-SverigeUniversitet.

PurusotamBasnet• Semenqualityandoxidativestress

Semenqualityhasbeenfoundtobedeterioratingtrendatlarge.Oneofthecauseshasbeenpointedtotheoxidativestress.APhDprojectisdevelopedtostudysemenqualityamongthehealthypopulationandmenneededinfertltytreatmentintheNorthernNorwayandtheirrootcauseofdeteriorationtogetherwithoxidativestress.ProjectleaderPurusotamBasnetisworkingwithcollaboratorsMarthaA.Hentemann,GaneshAcharyaandNatasaSkalkoBasnet.

• SpermatozoamotilityandviabilityDifferentsupplementsinthemediatoincreaseinvitromotilityandviabilityofspermcellshavebeenscreened.ProjectleaderPurusotamBasnetisworkingwithcollaboratorsMarthaA.Hentemann,NatasaSkalkoBasnet.

• OxidativestressinhumanembryopreimplantationstageApreliminarymethodforthemeasurementofoxidativestressinthepre-implantedhumanembryoisunderdevelopment.

• SubcellularanatomyofpreimplantedhumanembryousingnanoscopyThisisapartoftheprojectfundedbyUiTStrategicGrantfortheestablishmentofCentreforAdvancedNanoscopytoDecodeSub-cellularBiologicalSystems.ThisworkpackageisapprovedbyUiTforthePhDresearchwithPrincipalsupervisorPurusotamBasnetandco-supervisorsGaneshAcharya,andBalpreet

12

Ahluwalia.

• Norway-IndiaProjectThisisaninternationalprojectbetweenNorwegianpartners(DepartmentofPhysicsUniversityofTromsø,UniversityofTromsø,UniversityHospitalofNorthNorway,Tromsø)togetherwithIndianpartners(IndianInstituteofTechnology,NewDehli,Indiaandotherinstitutions).ThegrantissupportedbyNorwegianResearchCouncil.Mainobjectivesofthestudyaretodevelopnonlabelingmethodstostudysubcellularstructuresusingnanoscopytechnique.

ÅshildBjørneremResearchfocus

• Bonefragility-pathophysiology,diagnosisandprevention• Diabetesandpregnancy

Currentresearchprojects• Lactation,MenopauseandBoneHealth

TheresearchonLactation,MenopauseandBoneFragilitybasedondatacollectedduringherpost-doctoralinMelbourne,Australiaisongoing,withfocuson3Darchitectureofbone-toincreaseourunderstandingofthepathophysiologybehindbonefragility.

• PathophysiologyandDiagnosis–BonestructurestudyAnextentionoftheMelbourneworkafterreturningtoTromsøisauniqueopportunitytotesthypothesisondiagnostictoolsforassessmentoffractureriskbyusingarelativelynewsoftwaredevelopedinMelbourneforanalysisofCTimages,basedonfracturecasesandcontrolsinthepopulation-basedTromsøstudy.Thisresearchfocusesonpathophysiologyofbonefragility,anddiagnostictooltobetteridentifythosewhoareinneedoftreatment.

• SecondarypreventionofFractureNoFRACT–NorwegianCapturetheFractureInitiativeisahugenationalstudyinvolvingsecondaryfractureprevention.AllwomenandmenwithfracturesatsevenNorwegianhospitalsareidentified,offeredexaminationandtreatmentforosteoporosis.Theeffectofintroducingthisinterventiononre-fracturesratesandmortatlitywillbemeasuredusingnationalregistersduring2008-2020.

• DiabetesandPregnancyAqualityassurancestudyincludewomenwithandwithoutdiabetesduringgestationinNorthernNorway,forassessmentofcomplicationsofdiabetes,andfactorsassociatedwithcomplications.

FrancescoD’Antonio • Prenataldiagnosisofabnormallyinvasiveplacenta(AIP)byultrasoundandMRI.

Iamoneoftheleadinvestigatorsofamulticenterprospectivestudyinvolving20centersinItalyaimingatascertainingthedegreeofassociationofdifferentultrasoundandmagneticresonanceimagingsignsindetectingthepresenceofAIPfromthefirsttrimesteronwards.ThedatacollectionstartedlastSeptember.EstimatedcompletiondatehasbeensetinDecember2017

13

• Placentalinsufficiencyandintra-uterinegrowthrestriction.IampartoftheTruffle-2Study,amulticenterprospectivestudyinvolvingseveralcentersinEuropeaimingatascertainingtheroleoffetalDopplerinidentifyingfetusesaffectedbylateonsetintra-uterinegrowthrestrictionathigherriskofperinatalcompromise.

• MultiplepregnanciesIamtheleadinvestigatoroftheSTORKgroup,aresearchcollaborativeincluding9hospitalsintheSouth-westregionofThames.SeveralstudieshavealreadybeenpublishedinthelasttwoyearsaspartofmyPhDthesis.Thedataanalysisiscontinuing;themaintopicofthefuturepublicationswillbeperinataloutcomeoftwinpregnanciesafteronetwindeath,perinatalmorbidityintwinpregnanciesaffectedbybirthweightdiscordanceandperinataloutcomeinhighordermultiplegestations.

• Pre-andpost-natalfetalDopplerIamtheleadinvestigatorofalargeprospectivestudycarriedoutinItalyonthecorrelationbetweenpreandpost-natalDopplerinuncomplicatedpregannciesandinthoseaffectedbyintra-uterinegrowthrestriction.

Othermembersoftheresearchgroupareinvolvedintheseprosjects(notpresentedabove):

• UtviklingavnymålemetodeogbehandlingsmetodehoskvinnermedurininkontinensProjectleaderGunnarLeivsethcollaboratingwithIngardNilsen.

• Plateletsandplacenta–thenewhotspotinfetal-matenalcrosstalkProjectleaderHeidiTiller.CollaborationwithMonaNystadandGaneshAcharya.

• ResearchonplacentalgenomicsCollaborationwithProf.AndresSalumetsUniversityofTartu-ReproductiveCompetenceCenteronReproductionMedicine&BiologyandMonaNystad.

• EpigeneticchangesinpreeclampsiaCollaborationwithProf.AndresSalumetsUniversityofTartu-ReproductiveCompetenceCenteronReproductionMedicine&Biology.CooperationpartnerTartuUniversity:TriinViltropMSc(PhDcandidate)andGaneshAcharyaandMonaNystad.

• Maternalhemodynamics,endothelialfunctionandplacentalbloodflow.Co-worker:KariFlo(seealsosameprojectsunderG.Acharya).

• PlacentatissueimaginginSuperResolutionbyNanoscopyCollabotationwithassociateprofessorBalpreetSinghAhluwalia,LuisVillagasHernandez,CristinaIonicaØie,MonaNystadandPurusotomBasnet.

14

Publications1. AcharyaG.Improvingresearchinwomen'shealthinNordiccountries:challengesandopportunities

ahead.ActaObstetGynecolScand.2017Dec;96(12):1397-1398.doi:10.1111/aogs.13255.PubMedPMID:29168182.

2. WidnesC,FloK,WilsgaardT,OdiboAO,AcharyaG.SexualDimorphisminUmbilicalVeinBloodFlowDuringtheSecondHalfofPregnancy:ALongitudinalStudy.JUltrasoundMed.2017Dec;36(12):2447-2458.doi:10.1002/jum.14286.Epub2017Jun24.PubMedPMID:28646626.

3. OdiboAO,AcharyaG.Externalvalidityinperinatalresearch.ActaObstetGynecolScand.2017Nov28.doi:10.1111/aogs.13268.[Epubaheadofprint]Review.PubMedPMID:29192962.

4. AltmäeS,AcharyaG,SalumetsA.CelebratingBaer-aNordicscientistwhodiscoveredthemammalianoocyte.ActaObstetGynecolScand.2017Nov;96(11):1281-1282.doi:10.1111/aogs.13234.PubMedPMID:29034960.

5. AcharyaG,BhideA,RäsänenJ.Clinicaltrialsinpreeclampsia:implicationsforpractice.ActaObstetGynecolScand.2017Oct;96(10):1157-1158.doi:10.1111/aogs.13227.PubMedPMID:28944468.

6. LiangH,YinC,DongX,AcharyaG,LiX.Clustersofweek-specificmaternalgestationalweightgainpatternandtheirassociationwithbirthweight:anobservationalcohortstudy.ActaObstetGynecolScand.2017Oct;96(10):1251-1260.doi:10.1111/aogs.13204.PubMedPMID:28815546.

7. AcharyaG.SevendangerousPsofpregnancyandchallengesofcaringforpregnantwomenwithcomplexneeds.ActaObstetGynecolScand.2017Sep;96(9):1037-1038.doi:10.1111/aogs.13165.PubMedPMID:28812317.

8. DahlJ,RefsumE,AhlenMT,EgelandT,JensenT,VikenMK,StugeTB,AcharyaG,HusebekkA,SkogenB,TillerH.Unravelingtheroleofmaternalanti-HLAclassIantibodiesinfetalandneonatalthrombocytopenia-Antibodyspecificityanalysisusingepitopedata.JReprodImmunol.2017Aug;122:1-9.doi:10.1016/j.jri.2017.06.003.Epub2017Jun27.PubMedPMID:28686909.

9. FamiliariA,MorlandoM,SonessonSE,RizzoG,AcharyaG,ManzoliL,D'AntonioF.ResponsetoLetterRegardingArticle,"RiskFactorsforCoarctationoftheAortaonPrenatalUltrasound:ASystematicReviewandMeta-Analysis".Circulation.2017Jul18;136(3):338-339.doi:10.1161/CIRCULATIONAHA.117.029014.PubMedPMID:28716837.

10. HerlingL,JohnsonJ,Ferm-WidlundK,BergholmF,LindgrenP,SonessonSE,AcharyaG,WestgrenM.AutomatedanalysisoffetalcardiacfunctionusingcolortissueDopplerimaging.UltrasoundObstetGynecol.2017Jul17.doi:10.1002/uog.18812.[Epubaheadofprint]PubMedPMID:28715153.

15

11. AcharyaG.Impactofchangingglobalpoliticallandscapeonwomen'shealthpriorities.ActaObstetGynecolScand.2017Jul;96(7):793-794.doi:10.1111/aogs.13141.PubMedPMID:28635002.

12. BasciettoF,LiberatiM,MarroneL,KhalilA,PaganiG,GustapaneS,LeombroniM,BucaD,FlaccoME,RizzoG,AcharyaG,ManzoliL,D'AntonioF.Outcomeoffetalovariancystsdiagnosedonprenatalultrasoundexamination:systematicreviewandmeta-analysis.UltrasoundObstetGynecol.2017Jul;50(1):20-31.doi:10.1002/uog.16002.Epub2017Jun7.Review.PubMedPMID:27325566.

13. ZhouQ,WangQ,ShenH,ZhangY,ZhangS,LiX,AcharyaG.RubellavirusimmunizationstatusinpreconceptionperiodamongChinesewomenofreproductiveage:Anation-wide,cross-sectionalstudy.Vaccine.2017May25;35(23):3076-3081.doi:10.1016/j.vaccine.2017.04.044.Epub2017Apr26.PubMedPMID:28456531.

14. AcharyaG.Roleofmicrobesinmaternalandchildhealth-Friendsorfoes?ActaObstetGynecolScand.2017May;96(5):517-518.doi:10.1111/aogs.13134.PubMedPMID:28429534.

15. BhideA,RasanenJ,HuhtaH,JunnoJ,ErkinaroT,OhtonenP,HaapsamoM,AcharyaG.EffectofHypoxemiaonFetalVentricularDeformationinaChronicallyInstrumentedSheepModel.UltrasoundMedBiol.2017May;43(5):967-973.doi:10.1016/j.ultrasmedbio.2017.01.010.Epub2017Mar6.PubMedPMID:28268036.

16. BhideA,SebireN,AbuhamadA,AcharyaG,SilverR.Morbidlyadherentplacenta:theneedforstandardization.UltrasoundObstetGynecol.2017May;49(5):559-563.doi:10.1002/uog.17417.PubMedPMID:28120421.

17. WagleM,AcharyaG,BasnetP,TrovikTA.Knowledgeaboutpreventivedentistryversusself-reportedcompetenceinprovidingpreventiveoralhealthcare-astudyamongNepalesedentists.BMCOralHealth.2017Apr12;17(1):76.doi:10.1186/s12903-017-0366-5.PubMedPMID:28403843;PubMedCentralPMCID:PMC5389144.

18. BhideA,AcharyaG.Theunmeasuredcostofpretermlaborscreeningprograms.ActaObstetGynecolScand.2017Apr;96(4):393-394.doi:10.1111/aogs.13125.PubMedPMID:28345227.

19. JøraholmenMW,BasnetP,AcharyaG,Škalko-BasnetN.PEGylatedliposomesfortopicalvaginaltherapyimprovedeliveryofinterferonalpha.EurJPharmBiopharm.2017Apr;113:132-139.doi:10.1016/j.ejpb.2016.12.029.Epub2017Jan11.PubMedPMID:28087379.

20. ThapaSB,AcharyaG.Women'shealthisnotinfocusindisasterzones:lessonsfromtheNepalearthquake.JFamPlannReprodHealthCare.2017Apr;43(2):92-93.doi:10.1136/jfprhc-2016-101605.Epub2016Dec9.PubMedPMID:27940443.

21. GudmundssonS,FloK,GhoshG,WilsgaardT,AcharyaG.Placentalpulsatilityindex:anew,moresensitiveparameterforpredictingadverseoutcomeinpregnanciessuspectedoffetalgrowthrestriction.ActaObstetGynecolScand.2017Feb;96(2):216-222.doi:10.1111/aogs.13060.PubMed

16

PMID:27858967.

22. AcharyaG.Movingforwardwithchangingtimes.ActaObstetGynecolScand.2017Jan;96(1):5-6.doi:10.1111/aogs.13070.PubMedPMID:28032646.

23. BhideP,VårtunÅ,AuneB,FloK,BasnetP,AcharyaG.Ovarianreserveinwomenwithaprevioushistoryofseverepre-eclampsia.ArchGynecolObstet.2017Jan;295(1):233-238.doi:10.1007/s00404-016-4193-8.Epub2016Sep7.PubMedPMID:27604242.

24. WidnesC,FloK,AcharyaG.Exploringsexualdimorphisminplacentalcirculationat22-24weeksofgestation:Across-sectionalobservationalstudy.Placenta.2017Jan;49:16-22.doi:10.1016/j.placenta.2016.11.005.Epub2016Nov12.PubMedPMID:28012450.

25. JauniauxE,Ayres-de-CamposD;FIGOPlacentaAccretaDiagnosisandManagementExpertConsensusPanel.FIGOconsensusguidelinesonplacentaaccretaspectrumdisorders:Introduction.IntJGynaecolObstet.2017;140(3):261-264.

26. JauniauxE,ChantraineF,SilverRM,Langhoff-RoosJ;FIGOPlacentaAccretaDiagnosisandManagementExpertConsensusPanel.FIGOconsensusguidelinesonplacentaaccretaspectrumdisorders:Epidemiology.IntJGynaecolObstet.2017;140(3):265-273.

27. SentilhesL,KayemG,ChandraharanE,Palacios-JaraquemadaJ,JauniauxE;FIGOPlacentaAccretaDiagnosisandManagementExpertConsensusPanel.FIGOconsensusguidelinesonplacentaaccretaspectrumdisorders:Conservativemanagement.IntJGynaecolObstet.2017;140(3):291-298.

28. JauniauxE,BhideA,KennedyA,WoodwardP,HubinontC,CollinsS;FIGOPlacentaAccretaDiagnosisandManagementExpertConsensusPanel.FIGOconsensusguidelinesonplacentaaccretaspectrumdisorders:Prenataldiagnosisandscreening.IntJGynaecolObstet.2017;140(3):274-280.

29. AllenL,JauniauxE,HobsonS,Papillon-SmithJ,BelfortMA;FIGOPlacentaAccretaDiagnosisandManagementExpertConsensusPanel.FIGOconsensusguidelinesonplacentaaccretaspectrumdisorders:Nonconservativesurgicalmanagement.IntJGynaecolObstet.2017;140(3):281-290.

30. CiardulliA,D'AntonioF,Magro-MalossoER,SacconeG,ManzoliL,RadolecM,BerghellaV.Maternalsteroidtherapyforfetuseswithimmune-mediatedcompleteatrioventricularblock:asystematicreviewandmeta-analysis.JMaternFetalNeonatalMed.2017Dec17:1-261.

31. CalìG,Timor-TrischIE,Palacios-JaraquemadaJ,MonteaugudoA,ForlaniF,MinneciG,FotiF,BucaD,FamiliariA,ScambiaG,LiberatiM,D'AntonioF.Changesinultrasonographyindicatorsofabnormallyinvasiveplacentaduringpregnancy.IntJGynaecolObstet.2018Mar;140(3):319-325.

32. D'AntonioF,OdiboAO,PrefumoF,KhalilA,BucaD,FlaccoME,LiberatiM,ManzoliL,AcharyaG.Weightdiscordanceandperinatalmortalityintwinpregnancies:asystematicreviewandmeta-analysis.UltrasoundObstetGynecol.2017Nov20.doi:10.1002/uog.18966.

17

33. CaissuttiC,FamiliariA,KhalilA,FlaccoME,ManzoliL,ScambiaG,CagnacciA,D'antonioF.Smallfetalthymusandadverseobstetricaloutcome:asystematicreviewandameta-analysis.ActaObstetGynecolScand.2018Feb;97(2):111-121.

34. D'AntonioF,ThilaganathanB,LaoretiA,KhalilA;SouthwestThamesObstetricResearchCollaborative(STORK).Birthweightdiscordanceandneonatalmorbidityintwinpregnancies:AnalysisoftheSTORKmultiplepregnancycohort.UltrasoundObstetGynecol.2017Oct13.doi:10.1002/uog.18916.

35. PaganiG,CaliG,AcharyaG,TrischIT,Palacios-JaraquemadaJ,FamiliariA,BucaD,ManzoliL,FlaccoME,FanfaniF,LiberatiM,ScambiaG,D'antonioF.Diagnosticaccuracyofultrasoundindetectingtheseverityofabnormallyinvasiveplacentation:asystematicreviewandmeta-analysis.ActaObstetGynecolScand.2018Jan;97(1):25-37.

36. D'AntonioF,Timor-TritschIE,Palacios-JaraquemadaJ,MonteagudoA,BucaD,ForlaniF,MinneciG,FotiF,ManzoliL,LiberatiM,AcharyaG,CalìG.First-trimesterdetectionofabnormallyinvasiveplacentainhigh-riskwomen:systematicreviewandmeta-analysis.UltrasoundObstetGynecol.2018Feb;51(2):176-183.

37. FamiliariA,MorlandoM,SonessonSE,RizzoG,AcharyaG,ManzoliL,D'AntonioF.ResponsetoLetterRegardingArticle,"RiskFactorsforCoarctationoftheAortaonPrenatalUltrasound:ASystematicReviewandMeta-Analysis".Circulation.2017Jul18;136(3):338-339.

38. CalìG,Timor-TritschIE,Palacios-JaraquemadaJ,MonteaugudoA,BucaD,ForlaniF,FamiliariA,ScambiaG,AcharyaG,D'AntonioF.OutcomeofCesareanscarpregnancymanagedexpectantly:systematicreviewandmeta-analysis.UltrasoundObstetGynecol.2018Feb;51(2):169-175.

39. BucaDIP,KhalilA,RizzoG,FamiliariA,DiGiovanniS,LiberatiM,MurganoD,RicciardulliA,FanfaniF,ScambiaG,D'AntonioF.Outcomeofprenatallydiagnosedfetalheterotaxy:Asystematicreviewandmeta-analysis.UltrasoundObstetGynecol.2017Jun12.doi:10.1002/uog.17546.

40. ScalaC,MorlandoM,FamiliariA,LeoneRobertiMaggioreU,FerreroS,D'AntonioF,KhalilA.FetalTricuspidRegurgitationintheFirstTrimesterasaScreeningMarkerforCongenitalHeartDefects:SystematicReviewandMeta-Analysis.FetalDiagnTher.2017;42(1):1-8.

41. RizzoG,AielloE,BosiC,D'AntonioF,ArduiniD.Fetalheadcircumferenceandsubpubicangleareindependentriskfactorsforunplannedcesareanandoperativedelivery.ActaObstetGynecolScand.2017Aug;96(8):1006-1011.

42. LucaroniF,MorcianoL,RizzoG,D'AntonioF,BuonuomoE,PalombiL,ArduiniD.Biomarkersforpredictingspontaneouspretermbirth:anumbrellasystematicreview.JMaternFetalNeonatalMed.2018Mar;31(6):726-734

43. D'AntonioF,ThilaganathanB,DiasT,KhalilA;SouthwestThamesObstetricResearchCollaborative(STORK).Influenceofchorionicityandgestationalageatsinglefetallossonriskofpretermbirthintwinpregnancy:analysisofSTORKmultiplepregnancycohort.UltrasoundObstetGynecol.2017

18

Dec;50(6):723-727.

44. FamiliariA,MorlandoM,KhalilA,SonessonSE,ScalaC,RizzoG,DelSordoG,VassalloC,ElenaFlaccoM,ManzoliL,LanzoneA,ScambiaG,AcharyaG,D'AntonioF.RiskFactorsforCoarctationoftheAortaonPrenatalUltrasound:ASystematicReviewandMeta-Analysis.Circulation.2017Feb21;135(8):772-785.

45. SacconeG,CiardulliA,XodoS,DugoffL,LudmirJ,D'AntonioF,BoitoS,OlearoE,VotinoC,MaruottiGM,RizzoG,MartinelliP,BerghellaV.Cervicalpessaryforpreventingpretermbirthintwinpregnancieswithshortcervicallength:asystematicreviewandmeta-analysis.JMaternFetalNeonatalMed.2017Dec;30(24):2918-2925.

46. BucaD,PaganiG,RizzoG,FamiliariA,FlaccoME,ManzoliL,LiberatiM,FanfaniF,ScambiaG,D'AntonioF.OutcomeofmonochorionictwinpregnancywithselectiveintrauterinegrowthrestrictionaccordingtoumbilicalarteryDopplerflowpatternofsmallertwin:systematicreviewandmeta-analysis.UltrasoundObstetGynecol.2017Nov;50(5):559-568.

47. LeombroniM,LiberatiM,FanfaniF,PaganiG,FamiliariA,BucaD,ManzoliL,ScambiaG,RizzoG,D'AntonioF.Diagnosticaccuracyofultrasoundinpredictingbirth-weightdiscordanceintwinpregnancy:systematicreviewandmeta-analysis.UltrasoundObstetGynecol.2017Oct;50(4):442-450.

48. SlettenET,ArnesM,LysaLM,MoeBT,StraumeB,OrboA.Predictionofrelapseaftertherapywithdrawalinwomenwithendometrialhyperplasia:Alongtermfollow-upstudy.AnticancerRes.2017May;37(5):2529-2536.

49. EgenbergS,ØianP,EggebøTM;ArsenovicMG.BruLE.Changesinself-efficacy,collectiveefficacyandpatientoutcomefollowinginterprofessionalsimulationtrainingonpostpartumhaemorrhage.JournalofClinicalNursing2017;Volum26(19-20).ISSN0962-1067.s3174-3187.sdoi:10.1111/jocn.13666.

50. BlixE,ØianP,TegnanderE.Metoderforfosterovervåkingunderfødslen.Kapittel35i:Jordmorboka,side507-520.CappelenDamm2017(ISBN9788202484316).

51. BlixE,WisborgT,ØianP.Livreddendeførstehjelpvedakuttesituasjoner.Kapittel40i:Jordmorboka,side573-608.CappelenDamm2017(ISBN9788202484316).

52. BernitzS,DalbyeR,ØianP,Zhang,J,EggebøTM,BlixE.Studyprotocol:theLaborProgressionStudy,LAPS-doestheuseofdynamicprogressionguidelineinlaborreducetherateofintrapartumcesareansectionsinnulliparouswomen?Amulticenter,clusterrandomizedtrialinNorway..BMCPregnancyandChildbirth2017;Volum17(1).ISSN1471-2393.sdoi:10.1186/s12884-017-1553-8.

53. JohansenL,PayASD,BroenL,RolandB,ØianP.Følgesfastsattekvalitetskravifødselsomsorgen?TidsskriftforDennorskelegeforening2017;Volum137(17).ISSN0029-2001.s1-8.sdoi:10.4045/tidsskr.16.1070.

54. EgenbergS,MasengaG,BruLE,EggebøTM,MushiC,MassayDA,ØianP.Impactofmulti-professional,scenario-basedtrainingonpostpartumhemorrhageinTanzania:Aquasi-experimental,pre-vs.post-

19

interventionstudy.BMCPregnancyandChildbirth2017;Volum17:87.ISSN1471-2393.s1-11.sdoi:10.1186/s12884-017-1478-2.

55. RosenlundIM,LeivsethL,NilsenI,FørdeOH,RevhaugA.Extent,regionalvariationandimpactofgynecologistpaymentmodelsinroutinepelvicexaminations:Anationwidecross-sectionalstudy.BMCWomen'sHealth2017;Volum17:114.ISSN1472-6874.s1-8.sdoi:10.1186/s12905-017-0471-2.

56. OsimaM,KralR,BorgenTT,HøgestølIK,JoakimsenRM,EriksenEF,BjørneremÅ.Womenwithtype2diabetesmellitushavelowercorticalporosityoftheproximalfemoralshaftusinglow-resolutionCTthannondiabeticwomen,andincreasingglucoseisassociatedwithreducedcorticalporosity.Bone2017;Volum97.ISSN8756-3282.s252-260.sdoi:10.1016/j.bone.2017.01.037.

57. BjørneremÅ,WangX,BuiM,Ghasem-ZadehA,HopperJL,ZebazeR,SeemanE.Menopause-RelatedAppendicularBoneLossisMainlyCorticalandResultsinIncreasedCorticalPorosity.JournalofBoneandMineralResearch2017.ISSN0884-0431.sdoi:10.1002/jbmr.3333.

58. OsimaM,BorgenTT,LukicM,GrimnesG,JoakimsenRM,EriksenEF,BjørneremÅ.Serumparathyroidhormoneisassociatedwithincreasedcorticalporosityoftheinnertransitionalzoneattheproximalfemurinpostmenopausalwomen:theTromsøStudy.OsteoporosisInternational2017.ISSN0937-941X.s1-11.sdoi:10.1007/s00198-017-4298-3.

59. KralR,OsimaM,BorgenTT,VestgaardR,RichardsenE,BjørneremÅ.IncreasedcorticalporosityandreducedcorticalthicknessoftheproximalfemurareassociatedwithnonvertebralfractureindependentofFractureRiskAssessmentToolandGarvanestimatesinpostmenopausalwomen.PLoSONE2017;Volum12(9).ISSN1932-6203.sdoi:10.1371/journal.pone.0185363.

60. BjørneremÅ,Ghasem-ZadehA,WangX,BuiM,WalkerSP,ZebazeR,SeemanE.IrreversibleDeteriorationofCorticalandTrabecularMicrostructureAssociatedWithBreastfeeding.JournalofBoneandMineralResearch2017;Volum32(4).ISSN0884-0431.s681-687.sdoi:10.1002/jbmr.3018.

61. FrøyshovHM,BjørneremÅ,EngstadT,HalvorsenDS.Elevatedinflammatorymarkerspredictmortalityinlong-termischemicstroke-survivors:apopulation-basedprospectivestudy.AgingClinExpRes.2017;29(3):379-385.

Publishedabstracts1. BasnetP,JøraholmenMW,AcharyaA,Skalko-BasnetN.PregnancyHypertension:Vesicle-based

resveratrolformulationforthetopicaltreatmentofTrichomonasvaginaliscausedvaginalinfectionandinflammation.PregnancyHypertension.AnInternationalJournalofWomen'sCardiovascularHealth.2017,Volume9P.49

2. VårtunÅ,FloK,WidnesC,AcharyaG.Maternalfunctionalhemodynamicsandnatriureticpeptidesat22–24weeksofgestation.PregnancyHypertension:AnInternationalJournalofWomen's

20

CardiovascularHealth.Volume9.P29

3. AlanneL,HoffrenJ,HaapsamoM,JunnoJ,HuhtaH,ErkinaroT,BhideA,AcharyaG,RäsänenJ.Effectofsildenafilcitrateonfetalcentralhemodynamicsandplacentalvolumebloodflowduringhypoxemiainachronicsheepmodel.AmericanJournalofObstetrics&Gynecology216(1),S18

4. SmelandM,NystadM,LeknessundA,HicksonN,SjåvikK,JørgensenAandPrescottT.AnovelPIK3CAmutationinMegalencephaly–capillarymalformationsyndromewithextremebrainovergrowthand45,Xmosaicism:relatedorcoincidentalphenomena?EuropeanSocietyofHumanGenetics(ESHG)27–30.05.2017Copenhagen.

5. SmelandM,NystadM,LeknessundA,HicksonN,SjåvikK,JørgensenAandPrescottT.AnovelPIK3CAmutationinMegalencephaly–capillarymalformationsyndromewithextremebrainovergrowthand45,Xmosaicism:relatedorcoincidentalphenomenaNorwegianSocietyofHumanGenetics(NSHG)/NorwegianSocietyofMedicalGenetics(NFMG)conference07–08.11.2017Skien,Norway.

6. NtiamoahF,BjørneremÅ,EggenAE,EmausN,WaasethM.Theuseofbisphosphonatesfortreatmentofosteoporosisinageneralpopulation–TheTromsøstudy2007-8.NordicSocialPharmacyConferenceNSPC;June7-9,2017.

7. FouadM,BjørneremÅ,EggenAE,EmausN,WaasethM.Associationbetweenanti-osteoporoticdruguseandqualityoflife(QoL)inwomenandmenwithosteoporosis-across-sectionalanalysiswithintheTromsøstudy.ResearchinSocialandAdministrativePharmacy2017;Volum13.(3)s.e8

8. KralR,OsimaM,BorgenTT,RichardsenE,BjørneremÅ.AddingCorticalPorositytoGarvanorFRAXtoolsImproveIdentificationofPostmenopausalWomenwithNonvertebralFracture:TheTromsøStudy.AmericanSocietyofBoneandMineralResearchAnnualMeeting2017;Denver,USA,Sept8-11,2017.

9. OsimaM,BorgenTT,LukicM,GrimnesG,JoakimsenRM,EriksenEF,BjørneremÅ.

Serumparathyroidhormoneisassociatedwithincreasedcorticalporosityoftheinnertransitionalzoneattheproximalfemurinpostmenopausalwomen:TheTromsøStudy.ASBMRDenver,USASept8-122017.

10. AndreasenC,OsimaM,RognliV,GrundelDE,ElvenesJ,Knutsen,G,MeknasK,JoakimsenRM,BorgenTT,SolbergLB,FrihagenFJ,NordslettenL,EriksenEF,BassoT,DahlC,OmslandTK,Bjørnerem,Å.Tromsoporosis-AdherencetoaSecondaryFracturePreventionPrograminTromsø,Norway.ASBMR,Denver,USASept8-12,2017.

11. VisheshD,BasnetP,WolfsonDL,AcharyaG,AhluwaliaBS(2017)InvestigationofInflammatoryresponseofmacrophagesusingstructuredilluminationmicroscopyandquantitativephasemicroscopy.conferenceonQuantitativePhaseImagingIV,partofSPIEBiOS,http://spie.org/BO506.PW18B-BO506-97

21

12. JøraholmenMW,BasnetP,AcharyaG,Skalko-BasnetN(2017)PEGylatedliposomesfortopicalvaginaltherapy:Improveddeliveryofinterferonalpha.31thCongressofIUSTI-Europe.Aug31-Sept2,Helsinki.Fomland(Posterpresentation).Bestposteraward

13. BasnetP,JøraholmenMW,AcharyaG,Skalko-BasnetN(2017)Vesicle-basedresveratrolformulationfor

thetopicaltreatmentTrichomonasvaginaliscausedvaginalinfectionandinflammation.ISSHPEuropeanCongress,September6-September9,2017,Berlin,Germany(Posterpresentation).

14. SinghR,WolfsonDL,BasnetP,AcharyaG,AhluwaliaBS(2017)Inflammatoryresponseofmacrophagesand

trophoblastsstudiedusingstructuredilluminationmicroscopy(SIM)andquantitativephaseimaging(QPI)InternationalFederationofPlacentaAssociation(IFPA),August30-September2,2017,Manchester,UK(Posterpresentation).

15. JøraholmenMW,BasnetP,AcharyaG,Skalko-BasnetN(2017)PEGylatedliposomesfortopicalvaginal

therapy:Improveddeliveryofinterferonalpha.6thPharmaceuticalScienceWorldCongress(PSWC)May21-24,Stockholm,Sweden(Posterpresentation).

Presentationsincongresses/conferences/meetingsGaneshAcharya:Invitedspeakerat:1. 4thRedHouseForum--InternationalObstetrics&GynecologySummit,Shanghai,China2-4June2017

2. 4.NordicFertilitySocietyCongress,Nyborg,Denmark.2-5August2017

3. 5.IFPACongress,Manchester,UK.30August-2September2017

4. ISSHPEurpeanCongress,Berlin,Germany.6-9September2017

5. NordicNetworkforFetalMedicineMeeting,Helsinki,Finland.18-19May2017

FrancescoD’Antonio:1. Agenesisofthecorpuscallosuminthefetus.ItalianCongressofUltrasoundinObstetricsand

Gynecology,Florence,September2017.

2. Fetalcardiacfunctioninintra-uterinegrowthrestriction.ItalianCongressofUltrasoundinObstetricsandGynecology,Florence,September2017.

3. Ultrasoundinabnormallyinvasiveplacenta.ItalianCongressofUltrasoundinObstetricsandGynecology,Florence,September2017.

4. UltrasoundvsMRIdiagnosisofabnormallyinvasiveplacenta.InternationalCongressofAbnormallyinvasiveplacenta,Catania,March2017.

22

PurusotamBasnet1. InvitedSpeaker:AretherepossibilitiesfortheimprovementinIVFtreatment?IndianInstituteof

Technology,NewDelhi,IndiaonDec16,2017.

2. InvitedSpeaker:Subcellularanatomyofhumanembryousingopticalnanoscopy.ICentraldeoartmentofChemistry,TribhuvanUniversity,Kathmandu,Nepal,Feb22,2017.

3. InvitedSpeaker:Moderntoolsforresearchesinthefieldofbiodiversity,PokharaUniversity,Pokhara,

NepalFeb16,2017.OthersAndreasenC.Tromsoporosis.Beinforskningssymposium;Framlegg.Oslo4.mai2017.SolbergLB,FrihagenF,BassoT,GjesdalCG,EriksenEF,NordslettenL,OmslandTK,BorgenTT,FigvedW,WisløffT,HagenG,BjørneremÅ.UpdatesontheNorwegianCapturetheFracture®Initiative(NoFRACT).FragilityFractureNetworkGlobalCongress;Malmø,24.-26.aug.2017.Communicationtogeneralpublic1. OsimaM.Jakterpåbeinskjørhetsmekanismer.Diabetesforum[Fagblad]17.sept2017.

2. OsimaM,AndreasenC,AuneKW.Sikkerpåatduikkeerbeinskjør?UIT-NorgesArktiskeUniversitet

[Internett].20.sept.2017.

3. OsimaM,AndreasenC.NoFRACT:Ombruddogbruddforebygging.Populærvitenskapeligforedrag;Herakleumsykehjem,Tromsø,21.sept.2017.

4. OsimaM,AndreasenC,BjørneremÅ.NoFRACT.ForskningstorgetUiTNorgesArktiskeUniversitet.22.-23.Sept2017.

5. BjørneremÅ.BEINSKJØRHET-hvaeregentligdetteoghvorforerdetviktig?NorskOsteoporoseforbund.ÅpentmøtemedtemaetOsteoporose–beinskjørhet;Tromsø14.Sept2017.

6. KralR.RISIKOFAKTORERFORBRUDD-hvorforblirnoensprøogbrekkerbein?NorskOsteoporoseforbund.ÅpentmøtemedtemaetOsteoporose–beinskjørhet;Tromsø14.Sept2017.

7. AndreasenC.NOFRACT-PROSJEKTEToggodbehandlingforbeinskjørhet.NorskOsteoporoseforbund.ÅpentmøtemedtemaetOsteoporose–beinskjørhet;Tromsø14.Sept2017.

8. NystadM.Innleggpåfolkemøteitrondheimiregiavbioteknologirådet27.03.17samtdeltagelseipaneldebatt.Tittelpåforedrag.Non-invasivprenataltesting(NIPT).

9. NystadM.MedieoppslagAdresseavisa03.04.17:sierjatilblodprøvesomavslørerDownssyndrome.

23

Referees• KariFlo.BritishJournalofObstetricsandGynaecology(BJOG).• GaneshAcharya,PurusotamBasnet,ÅshildBjørnerem,FrancescoD’AntonioandPålØian:Several

internationaljournals.

Opponents• GaneshAcharya.FirstopponentPhDthesis.MarianneMunkSinding.Placentalfunctionestimatedby

T2*-weightedmagneticresonanceimaging.AlborgUniversity,Denmark

• PålØian.Secondopponent.Ph.Dthesis,UniversityofOslo:IdaKathrineGravensteen.Stillbirth:Women’slong-termqualityoflife,mentalhealthandthesubsequentpregnancy.Oslo14.06.2017.

• ÅshildBjørnerem.LeaderofcommitteeforevaluationofPhDthesis(3rdopponent)-AnnaUsynina:“Riskfactorsofadversepregnancyoutcomes:opportunitiesandperspectivesofbirthregistry-basedstudy.”Disputas08.02.2017.

• PurusotamBasnetevaluatedthePhDThesisofShahllaImam(Title:Studiesofflavonoidsfromseasomnalfruitsandtopicalformulationforcorrelationoftheirusefulnessinthemanagementofpersonalcareproblems)submittedtoFacultyofPharmacy,KarachiUniversity,Karachi,Pakistan.

• PurosotamBasnet.LeaderofPhDdefenceforAmarBhide.DepartmentofclinicalMedicine,UiT,Tromsø01.08.2017

Teachingincoursesotherthanobstetricsandgynecologyformedicalstudents

• PurusotamBasnet.Nonomedicinecourse(FAR-3043)intelligentTherapeutics(4hours)RepresentationtoUniversitybodies

• EliseSletten.Medlemidelemnekomite6.7Gynekologi,obstetrikkogkroniskesykdommerog6.4Onkologiiforbindelsemedplanleggingavnytt6.studieåretternystudieplan.

• ØysteinPedersenogÅshildBjørnerem:MentoridetlangsgåendeprosjektetPROFKOM.• ÅshildBjørnerem:DelemnelederforObsterikkoggynekologiMed-3601,delemne6.7.• ÅshildBjørnerem:DelemnelederforObsterikkoggynekologiMed-2520,internasjonaltsemester.• ÅshildBjørnerem:medlemeksamenskommisjonMed-2520,internasjonaltsemester.• ÅseVårtun:MedlemistyringsgruppaTRAVERS.• ÅshildBjørnerem:VicechairmanofRegionalCommitteeforMedical&HealthResearchEthics2013-

2017.RepresentationoutsideofUniversitybodies

• GaneshAcharya:BoardmemberNordicFederationofObstetricsandGynecology(NFOG)• GaneshAcharya:ChiefeditorActaObstetetriciaetGynecologicaScandinavica• GaneshAcharya:MedlemiNasjonalreferansegruppeforavansertfostermedisin

24

• GaneshAcharya:MedlemfraUSAMtilFaggruppenforobstetrikkoggynekologiunderdetnasjonalepubliseringsutvalgetimedisin.

• FrancescoD’Antonio:AssistantchiefeditorActaObstetetriciaetGynecologicaScandinavica• PålØian:HovedredaktørforVeilederifødselshjelp.DennorskeLegeforening/NorskGynekologisk

Forening• PålØian:MedlemiNorskGynekologiskforeningsNPEutvalg• PålØian:MedlemiNGFgruppeformaternelledødsfalliNorge• PurusotamBasnet:AssociateeditorofTheJournalofReproductiveBiotechnologyandfertility• IngardNilsen:MedlemiStyringsgruppenforrekrutteringogstabiliseringavgynekologeriHelse

Nord• ÅseVårtun:InternationalSociatyofUltrasoundinObstetricsandGynecology(ISUOG)