Annual Report 2005.doc

Annual ReportDivision of Endocrinology

University of Pittsburgh School of Medicine2004-2005

Academic year 2004-2005 has been another banner year for the Division of Endocrinology, on the academic, patient care, administrative front, teaching, training, and the national and international recognition fronts. With 33 faculty members, the Division is without question one of the largest, strongest and most stable in the US, and is a leader in academic, didactic and clinical endocrinology.

Faculty (As of July 1, 2005).

Full Time M.D. Full Time Ph.D.

1. Janet Amico 1. Alessandro Bisello2. Bankim Bhatt 2. Nicholas Brown3. Sue Challinor 3. James DeLany4. Fred DeRubertis 4. Nathalie Fiaschi-Taesch 5. Susan Greenspan 5. Adolfo Garcia-Ocaña6. Steven Hodak 6. Bret Goodpaster7. Jennifer Holst 7. Gary Marshall8. Mara Horwitz 8. Robert O’Doherty9. David Kelley 9. Linda Siminerio

10. Mary Korytkowski 10. Rupangi Vasavada11. Haruko Kuffner12. Shane LeBeau13. Harsha Rao14. Michelle Roberts Research Associates15. Roseanne Salata 1. Lisa Menchikova16. Maja Stefanovic-Racic 2. Vladimir Ritov17. Andrew Stewart 3. Karen Takane18. Frederico de Toledo 4. Cyrous Kangani19. Anthony Vagnucci

Clinical Care. Visits to the endocrine clinics at the University of Pittsburgh School of Medicine and UPMC continue to increase, as do clinical revenues. In recognition of this, UPMC leadership has expanded nursing and support staff substantially, is expanding the clinic space from 4000 to 7000 sf, and expanded the number of designated full time clinical endocrinologists from seven to ten, complemented by nine additional research-oriented MD faculty, who also perform clinical patient care. This means that the 19 MD faculty, together with the 14 PhD faculty, comprise one of the largest Endocrinology Divisions in the US. Over the past year, we have also developed a new and fully-staffed inpatient diabetes hospitalist service, comprised of an attending endocrinologist, two nurse practitioners and a designated clinical fellow, as well as residents and students. In addition to these services at UPMC, four Division endocrinologists provide outpatient and inpatient care at the Pittsburgh VA Medical Center, and this will increase to five with the addition of a fifth full time endocrinologist beginning in July, 2006. In regional terms, we have developed and validated a database of 90,000 patients with diabetes cared for in the 19 UPMC hospitals and their associated outpatient facilities and clinics in western

Pennsylvania. Remarkably, this is the largest diabetes registry of unselected patients in the US. (Medicare, the VA and Kaiser-Permanente have larger, but demographically selected diabetes registries.) We have also developed the second or third largest ADA-certified diabetes educator network in the US. Working with this University of Pittsburgh Diabetes Institute Registry and ADA-Certified Diabetes Education Network, we have launched quality improvement initiatives on a scale not possible in almost any other hospital system. We have also implemented system-wide computer-based physician order-entry initiatives targeting the inpatient management of hypoglycemia and sliding scale management of hyperglycemia, and also to site-specific and physician-specific reporting of ADA management targets. These have led to marked, large scale improvements in the management and outcomes relating to hypoglycemia, hospital length of stay, and achievement of compliance targets for diabetes management. Compliance measures and outcomes System-wide far exceed national averages and ADA guidelines. Finally, five of our clinicians were ranked among the Best Doctors in the US.

Research. Research continues to expand in the Division. In FY ’05, faculty within the Division received a total of $8,500,000 in research support from the NIH, the ADA, the JDRF, the AHA the VA, and from pharmaceutical trials, with the large majority coming from the NIH. Twelve of 15 research faculty cover all or most of their salary from NIH grants, and the remainder cover the large majority of their salary from the NIH and other foundations. Areas of excellence include clinical research in diabetes, obesity, calcium metabolism and osteoporosis, and basic research in diabetes, insulin resistance, pancreatic beta cell function, survival and regeneration, osteoblast and osteoclast biology, and arterial smooth muscle in health and disease. Research is supported by an NIH Training Grant, now in its 38th year, and which was recently renewed, by the NIH-funded General Clinical Research Center, and by the NIH-funded Obesity and Nutrition Research Center. Outstanding facilities for microarray gene profiling, DNA and protein synthesis and sequencing, animal care, proteomics, cellular imaging, and bioinformatics and biostatistics are available. Remarkably, Drs. Kelley, Greenspan, Stewart within the Division, and Drs. David Roodman and Mark Sperling who closely collaborate with Division members all have had one or more papers in the New England Journal of Medicine in the past year. From a research perspective, then, the Division clearly ranks among the top ten in the US. This excellence in research within the Division is complemented by the NIH ranking of the overall University of Pittsburgh, which ranked #7 out of 130 US Medical Schools in NIH support for 2003, the most recent year for which these numbers are available.

Teaching and Training. Division faculty rank among the best in the Medical School once again in both the second year medical students course, and also among resident and fellow teaching. In parallel, improvements in the quality and quantity of applicants for the fellowship has increased dramatically over the past five years. For example, for fellowship training slots beginning both in July 2005 and 2006, we received approximately 140-150 applicants per year, interviewed 10-12, and selected three to four per year. Of eight positions offered in the past two years, seven applicants accepted this program. Thus, 140-150 applicants compete for 3-4 slots per year. Training in clinical endocrinology is intense, rich, high-volume, and exceptionally diverse. Teaching and supervision are equally outstanding. Clinical care is also outstanding, and occurs at the University, Magee Women’s Hospital, Children’s Hospital of Pittsburgh, and the Oakland VA Medical Center. Training excellence is documented by 100 passage rate on the Endocrinology Board exams for the past 27 years, by the large proportion of training graduates who enter academic careers, and by the recent excellent score of our NIH Training Grant which will allow another five years of training support. A concrete example of the excellence in teaching is Dr. Rao’s winning (again!) the Distinguished Housestaff Teacher Award for the Department of Medicine

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Faculty Honors and Recognition.

Amico: Best Doctors in America 2004-2005

DeRubertis: Top Ranked Clinical Teacher in the Division 2004-2005

Garcia-Ocana: Senior Vice Chancellor’s Distinguished Lecture 2004

Greenspan: Appointed Clinical Program Chair, ASBMR Annual Meeting, 2006.Best Doctors in America 2004-2005Councilor, ASBMRCoordinating Author, US Surgeon General’s Report on Osteoporosis, 2005Vice Chair, Professional Practice Committee, National Osteoporosis

Foundation

Kelley: Elected to Association of American PhysiciansAmerican Diabetes Association Board of Directors

Korytkowski: America’s Best Doctors 2004-2005UPMC Presbyterian Presidential Performance Award for Patient Safety

Kuffner: Keynote Speaker, Japan-North America Medical Exchange Foundation, 2004

Rao: Physician Performance Award, VA Pittsburgh Health SystemDistinguished Housestaff Teacher Award, Department of Medicine

Salata: Best Doctors in America 2004-2005

Siminerio: Vice President and Member, Board of Directors, International Diabetes Federation

Chancellor’s Distinguished Public Service Award

Stewart: Co-Chair, NIH-ASBMR Conference on Anabolic Skeletal Agents for Osteoporosis, 2004

Invited Symposium Speaker, Royal Society of Medicine, London, 2004Best Doctors in America 2004-2005Chair, Science Policy Committee, American Diabetes Association

Individual Faculty Annual Reports. Individual Annual Reports from each Faculty Member follow below. Note that Drs. Bhatt, DeLany, LeBeau, Hodak, Holst are new arrivals and therefore have no Annual Repots.

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2004-2005

Name: Janet A. Amico, MD

Title: Professor

Section: Primary Appointment: Endocrinology, Department of Medicine, School of Medicine (SOM)

Secondary Appointment: Department of Pharmaceutical Sciences, School of Pharmacy (SOP)

Honors/ Committees:

a. National: America’s Top Doctors, 2004-2005Ad Hoc peer review 2004-2005: Endocrinology, JCEM, Brain Research, J of Neuroscience, Am J of Physiology, European J of Neuroscience, Arch Int Med, Hormones and Behavior, European J Pharmacology, J Neuroendocrinol, Experimental Neurology

Ad hoc peer review for NIH, Dept of Veterans Affairs, NIMH, Howard Hughes Medical Institute, New Zealand Research Council

b. University: Institutional Review Board for Biomedical Research (SOM/SOP)

c. Hospital: Utilization Review Committee (SOM)

d. Departmental: - Appointments and Promotions Committee (SOM)- Internship Interview Committee (SOM)- Medical School Interview Committee (SOM)- Focus Leader, Graduate program in NeuroEndocrine

Pharmacology (SOP)- Graduate Program Council (SOP)- Graduate Admissions Committee (SOP)- Distinguished Lectureship Committee (SOP)- Admissions Committee (SOP)- Ad Hoc Faculty Search Committees (SOP)

e. VA Hospital: None

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Invited Lectures/ Sessions:

U of North Carolina School of Medicine Sept 2004‘”Anxiety-related behavior and stress responses in female oxytocin deficient mice”

Research Topics

Stress, Anxiety and Ingestive Behaviors in the Oxytocin Deficient Mouse

Interrelationship of Oxytocin and Steroids in Cognitive Function and Affective Disorders

Grants/Awards/Contracts:Active:

1) 1RO1 HD044898-01 (Amico) 12-01/04-11/30/08 “Anxiety and Stress Responses in Oxytocin Deficient Mice”

Studies investigate the role of oxytocin in anxiety and stress

2) DOD BC030242 (Weihs) 01/01/05- 12/31/10 “Longitudinal effects of intimate partner relationship quality on serum oxytocin levels in newly diagnosed breast cancer patients”

Studies investigate if breast cancer patients with better quality relationships will have higher average blood levels of oxytocin than women without such relationships and if the blood level of oxytocin correlates with better outcome of the disease.

3) R01 HD37268 (Amico) 04/01/2000- 03/31/05 “Oxytocin Regulation by Neurosteroids & GABA-A Receptor”

Studies focus upon the GABA A mediated effects of steroids upon central oxytocin expression.

4) R01 HL068862 (Smith) 06/1/2003 - 5/31/08“Cardiovascular-Oxytocin Links in Social Interactions”

Studies investigate the role of oxytocin on stress markers in patients with cardiovascular disease

5) R01 DA05952 (Mezzich) 09/30/2001-05/31/06 “Female Adolescent Drug Abuse: Biobehavioral Development”

Studies investigate psychological and hormonal markers of substance abuse

6) K01 MH64144 (Cyranowski) 08/20/2001-7/31/05“Biobehavioral Mechanisms of Depression in Women

Mentored Research Scientist Development Award (MRSDA) investigates hormonal parameters affecting the etiology of depression in women.

PENDING

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7) 1RO1 MH074850 (Pedersen) 07/01/05 – 06/30/10 20%“Oxytocin & Nurture: Anxiety, Despair, & Mothering in Mice”

Studies investigate if altered maternal care has long term consequences in mice such as vulnerability to stress induced behavior

8) R01 HL64927 (Light) 12/01/05 -11/30/10“Cardiovascular Benefits of Family Support and Oxytocin”

The goal of the proposed research is to understand mechanisms by which oxytocin affects blood pressure response, cardiovascular reactivity and stress responses in humans.

PLANNED

9) (Amico) 12/01/05-11/30/10 “” Ingestive behaviors in oxytocin deficient mice”

Studies investigate the effects of oxytocin upon abnormal ingestive behiors

Publications for 2004-2005

a. ManuscriptsPublished

1. Fabian TJ, Amico JA, Kroboth PD, Mulsant Bh, Corey SE, Bagley AE, Bensasi SG, E, Dew MA, Reynolds, CF, Pollock BG. Paroxetine –induced hyponatremia in older adults: a twelve week prospective study Arch Int Med 164:327-332, 2004.

2. Amico JA, *Mantella RC, Vollmer RR, Li X, Cai HM. Anxiety and stress responses in female oxytocin deficient mice J of Neuroendocrinology 16:319-324, 2004.

3. Amico JA, Volmer RR, *Karam JR, Lee, PR, LI, X, Koenig JI, McCarthy MM Centrally administered oxytocin elicits exaggerated grooming in oxytocin null mice Pharmacology, Biochemistry and Behavior, 78:333-338, 2004.

4. Mantella RC, Rinaman L, Vollmer RR, Li X, Amico JA Enhanced plasma corticosterone concentrations and diminished Fos expression in the medial amygdala of female oxytocin deficient mice exposed to psychogenic stress American Journal of Physiology. , 287:R1494-R1504, 2004

5. Light KC, Grewen KM, Amico JA, Boccia M, Brownley KA, Johns JM Deficits in plasma oxytocin responses and increased negative affect, stress and blood pressure in mothers with cocaine exposure during pregnancy Addictive Behaviors, 29:1541-1564, 2004.

In Press

1. Rinaman L, Volmer RR, *Karam JR, Li X, Amico JA Attenuation of dehydration anorexia in oxytocin deficient mice American Journal of Physiology. in press, 2005.

2. Grewen K, Girdler SS, Amico JA, Light KC Effects of partner support on restingoxytocin, cortisol, norepinephrine, and blood pressure before and after warm partner contact Psychosomatic Medicine, in press, 2005.

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3. Light KC, Grewen KM, Amico JA More frequent partner hugs and higher oxytocin levels are linked to lower blood pressure and heart rate in premenopausal women Biological Psychology in press, 2005.

4. Light KC, Grewen KM, Amico JA, Brownley KA, West SG, Hinderliter AL, Girdler SS Oxytocinergic activity is linked to lower blood pressure and vascular resistance during stress in postmenopausal women on estrogen replacement Hormones and Behavior, in press, 2005.

5. Hruska MW, Amico JA, Langaee TY, Ferrell R, Fitzgerald SM, Frye RF The effect of trimethoprim on CYP2C8 mediated rosiglitazone metabolism in human liver microsomes and healthy subjects British Journal of Clinical Pharmacology in press, 2005.

Submitted

1. Pedersen CA, Boccia ML, Vadlamudi SV, Amico JA Maternal behavior deficits in nulliparous oxytocin knockout mice Genes, Brain and Behavior [submitted]

2. Mantella RC, Vollmer RR, Amico JA Overnight fluid deprivation heightens plasma corticosrterone concentratiojns in male oxytocin deficient mice Brain Research [submitted]

Abstracts : 5

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Annual Report of Educational ActivitiesDepartment of Internal Medicine


Name: Janet A. Amico, M.D.

Section: Medicine, Endocrinology

Type of Activity Date(s) Location/Course

I. AttendingA. Inpatient General MedicineB. Outpatient

1. Residents/fellows Weekly Clinic Weekly (Endo Clinic,SOM) Falk 2B2. Residents Ambulatory Block3. Students Ambulatory Block

C. Consult Service1. General Medicine2. Subspecialty (Endocrinology) August, 2004 (SOM) PUH/MUH/VA

D. Student Teaching AttendingE. 2nd Year Clinical Tutor - Clinical Skills October 2004, 12 h(SOM) PUH/MUH

F. Others (specify) Research Advisor: Rose Mantella (Ph D candidate, Pharmaceutical Sciences, SOP).

Research Advisor: Julie Miedlar (Ph D candidate,

Pharmaceutical Sciences, SOP).

II.Lecture/Seminar

A. For Residents/ Fellows - MKSAP Review, Thyroid(1 h) (SOM)

Summer lecture series, Physiology of Anterior and Posterior Pituitary (SOM)

B. For Students - Course-CoDirector, Endocrine Disorders Course (SOM), Nov-

Dec 2004 (3 weeks); two lectures (2 h), 3 PBL sessions (4 h)

- Course Coordinator 4th yr Selective in Endocrinology, I h/month

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-Doctoral Thesis Committees (4 students SOP and 1 student SOM)

-Pharm 3000 Topics in Neuroscience (SOP) Course Director - 1h weekly , 9/04 to 4/05

Pharm 5110: Exploring Research (3h) (SOP) Oct 2004

III. UPMC Medical Grand Rounds

IV. University Lectures University Endocrine Conference 4/05Vasopressin Receptor Antagonists: Development and Use in Patients with hyponatremia (SOM)

V. Teaching Evaluations: (SOM) Second Year Medical Students Rating of Teaching in the Endocrine Disorders Course: 3.8 for Lectures; 4.0 for PBL (Range 1 - 5, with 5 the best)

(SOM) Endocrine Fellows Rating of Teaching in the Fellowship Program: ranked # 3 out of 17 faculty in the Endocrinology Division( 5 yr average is also # 3)

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2004 - 2005

Name: Alessandro Bisello, Ph.D.

Title: Assistant Professor of MedicineAssistant Professor of Pharmacology (secondary)

Section: Endocrinology

Honors:Ad hoc reviewer for PNAS, Journal of Biological Chemistry, Endocrinology, Biochemistry, the Journal of Bone and Mineral Research, Trends in Endocrinology.

Committees:

a. National: Ad hoc Skeletal Biology Structure & Regeneration Study Section- NIH 2004Scientific Program Committee for the 26th Annual Meeting of the American Society of Bone and Mineral Research, Seattle, WA, USA.

b. University: NONE

c. Hospital: NONE

d. Departmental: Organizer Research Conference Series

e. Veterans Hospital:NONE

Invited Lectures, Seminars:

5/2004 Local Traffic 2004, University of Pittsburgh Title: Trafficking of the parathyroid hormone receptors: structural and functional significance”

Editor, Associate Editor: NONE

Research Topics:

a. Mechanisms of signal transduction of parathyroid hormone and PTH-related proteinb. Structure-activity studies on parathyroid hormone and PTH-related proteinc. Regulation of the Glucagon-like peptide 1 receptor.

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Grants/Awards/Contracts:

Active Direct Costs1. R01 DK062078-01(Bisello) NIH 07/02-06/06 $600,000

Parathyroid Hormone Signaling in Bone Cells

2. R01-51081 (Stewart) NIH 3/03-3/08 $50,000Pathophysiology of PTH-related Protein (1-35) in Humans

3. 2R01 DK54171-18-23(Friedman) NIH 7/03-7/08 $50,000Cellular Calcium Transport in Urinary Epithelia

4. Pilot/Feasibility Grant (Bisello) ONRC(NIH) 7/1/05-6/30/05 $15,000Regulation of the GLP-1 Receptor

Pending

1. 1R01 DK071158 (Bisello) NIH 2005-2010 $1,125,000PTH receptors in vascular smooth muscle cells.

2. R01 (Friedman) NIH 2005-2010 $100,000EBP50 regulation of PTH receptor signaling and trafficking.


a. Manuscripts

Published:

1. Bisello A, Manen D, Pierroz DD, Usdin TB, Rizzoli R, Ferrari SL. Agonist-specific regulation of parathyroid hormone (PTH) receptor type 2 activity: structural and functional analysis of PTH- and tuberoinfundibular peptide (TIP) 39-stimulated desensitization and internalization. Mol Endocrinol. 2004; 18:1486-98.

2. Sneddon WB, Magyar CE, Willick GE, Syme CA, Galbiati F, Bisello A, Friedman PA. Ligand-selective dissociation of activation and internalization of the parathyroid hormone (PTH) receptor: conditional efficacy of PTH peptide fragments. Endocrinology. 2004;145:2815-23.

3. Bisello A, Horwitz MJ, Stewart AF. Parathyroid hormone-related protein: an essential physiological regulator of adult bone mass. Endocrinology. 2004; 145:3551-3.

4. Syme CA, Friedman PA, Bisello A. Parathyroid hormone receptor trafficking contributes to the activation of extracellular signal-regulated kinases but is not required for regulation of cAMP signaling. J Biol Chem. 2004 Dec 17; [Epub ahead of print].

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In press or submitted: 1. Horwitz MJ, Tedesco MB, Sereika SM, Syed MA, Garcia-Ocaña A, Bisello A, Hollis BW, Rosen

CJ, Wysolmerski JJ, Dann P, Gundberg CM, Stewart AF. Continuous infusion of parathyroid hormone versus parathyroid hormone-related protein in humans: discordant effects on 1,25(OH)2 vitamin D and prolonged suppression of bone formation. (submitted) 2005.

2. Horwitz MJ, Tedesco MB, Sereika SM, Garcia-Ocaña A, Bisello A, Hollis BW, Gundberg CM, Stewart AF. Safety and Tolerability of Subcutaneous PTHrP(1-36) in Healthy Human Volunteers: A Dose Escalation Study. (submitted) 2005.

b. Abstracts: Four

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University of Pittsburgh School of Medicine2004 - 2005

Name: Alessandro Bisello, PhDSection: Internal Medicine, Endocrinology Type of Activity Date(s) Location/Course

I. AttendingA. Inpatient General Medicine NAB. Outpatient

1. Residents Weekly Clinic2. Residents Ambulatory Block3. Students Ambulatory Block

C. Consult Service1. General Medicine2. Subspecialty (Endocrinology) NA

D. Student Tutor E. 2nd Year Clinical TutorF. Others (specify) Research Advisor: Colin Syme, PhD

II. Lecture/Seminar

A. For Residents NONE

B. For Students January 2005; “Principles ofPharmacology” - 2 lectures

C. Others August 2004; “Introduction to signaling”. Lecture series for endocrine fellows

III. UPMC Medical Grand Rounds NONE

IV. Affiliated Hospital Program NONE

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2004 - 2005

Name: Nicholas F. Brown, Ph.D.

Title: Assistant Professor


Honors: None

Committees:

a. University: Redesign of MS 1 Fuel Metabolism Course curriculum


a. Tularik Inc., South San Francisco, CA (Aug, 2004)“Novel aspects of fatty acid metabolism in muscle and liver cells”

b. Bristol Myers Squib, Princeton, NJ (Aug, 2004)“Novel aspects of fatty acid metabolism in muscle and liver cells”

c. Wellstat Pharmaceuticals, DC (Sep, 2004)“Novel aspects of fatty acid metabolism in muscle and liver cells”

d. Metabasis Pharmaceuticals, San Diego, CA (Dec, 2004)“Beneficial effects of increased fatty acid oxidation in muscle and liver cells”

e. Novartis Institute for Biomedical Research, Cambridge, MA (Jan 2005)“Beneficial effects of increased fatty acid oxidation in muscle and liver cells

Editor, Associate Editor: None

Research Topics:a. Investigation of the structure/function and regulation of the mitochondrial carnitine

palmitoyltransferase (CPT) system of enzymes at a molecular level.b. Role of CPT I and acyl-CoA in the etiology of skeletal muscle insulin resistance.c. Role of immunosuppressant drugs in regulation of lipid metabolism.d. Role of CPT I in regulation of hepatic lipid metabolism in normal and disease states.

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Active Grant Support: Direct Costs

1. Junior Faculty Award (Brown) ADA 1/1/03-12/31/05 $120,000/yrCarnitine palmitoyltransferase, fatty acids and diabetes

2. Pilot and Feasibility Award (Brown) CMRF 1/7/02 - 6/30/05 $25,000 totalSkeletal muscle carnitine palmitoyltransferase I and insulin resistance

3. K08 (Stefanovic-Racic; Brown, mentor) NIH/NIDDK 4/1/04-3/31/09 $116,000/yrHepatic fatty acid metabolism and insulin resistance

4. R01 (Kelley; Brown, co-invest) NIDDK/NIH 7/1/04 - 6/30/09Mitochondrial impairment in muscle insulin resistance

5. R01 (Goodpaster; Brown, co-invest) NIH/NIDDK 7/1/04 – 6/30/08Muscle lipid and insulin resistance in aging


a. Manuscripts

Published:

1. Perdomo, G., Commerford, S.R., Adams, S.H., O’Doherty, R.M. and Brown, N.F. Increased -oxidation in muscle cells enhances insulin-stimulated glucose metabolism and protects against fatty acid induced insulin resistance despite intramyocellular lipid accumulation. J. Biol. Chem.2004; 279, 27177-27186

2. Sinha, S., Perdomo, G., Brown, N.F. and O’Doherty, R.M. Fatty acid induced insulin resistance in L6 myotubes requires nuclear translocation of NFB. J. Biol. Chem. 2004; 279, 41294-41301

3. Goodpaster, B.E. and Brown, N.F. Exercise and the role of skeletal muscle triglyceride in insulin resistance. Exercise and Sports Medicine Reviews 2005; (in press)

In Press or Submitted:

1. Perdomo, G., Stefanovic-Racic, M., Sipula, I. and Brown, N.F. Rapamycin promotes fatty acid oxidation and diminishes lipogenic pathways in primary cultures of rat hepatocytes. (submitted)

Abstracts: Two

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Name: Nicholas F. Brown, Ph.D.Section: Internal Medicine, Endocrinology Type of Activity Date(s) Location/Course

I. AttendingNot applicable

II. Lecture/Seminar

A. For Fellows July 2004 Techniques for isolating, characterizing and quantifying proteins. In, Introduction to Core Research Techniques.

Aug 2004 Lipoprotein Metabolism. In, Summer Lecture Series.

B. For Students Jan 2005 MS I Course, Fuel Metabolism: 5 lectures

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2004 - 2005

Name: Sue Challinor, MD

Title: Assistant Professor of Medicine


Honors: Best Doctors in America 2003-2004

Committees:

a. National: None

b. University: Director, Pituitary Conference

c. Hospital: None

d. Departmental: None

e. Veterans Hospital:None


a. Aug 2004 Cushings Syndrome: Endocrine Fellows Summer Lecture Series

b. Oct/Nov 2004 Pituitary Diseases: Pituitary Adenomas and Cushings Syndrome and Adrenal Insufficiency – Two lectures for 2nd year medical students – Endocrine Disorders Course

2 Problem-Based Learning Session on MEN 1

c. February 2005 The Utility of Gamma-Knife in the Treatment of Pituitary Tumors – The Pittsburgh Experience for University-Wide Endocrine Conference

d. April 2005 Pituitary Tumors: Noon Lecture Series for the Internal Medicine Housestaff at University of Pittsburgh Montefiore Hospital and at VA Hospital


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Research Topics:

a. The Global Hypopituitary Control and Complications Study: Principle Investigator- Industry-sponsored outcome study of GH therapy in hypopituitary patients

Research Grants: None


a. Manuscripts

Published: None

Submitted: Hypterthyroidism after Parathyroid Exploration. Stang MT, Yim JH, Challinor SM, Bahl S, Carty SE. submitted to Surgery, Feb 2005.

b. Abstracts: None

Other:Certification in Thyroid Ultrasound, at the AACE Thyroid Ultrasound and FNA Biopsy Accreditation Course, Jan 21-23, 2005.

Radiosurgery Practice Guidelines Initiative: Stereotactic Radiosurgery for Patients with Pituitary Adenomas, member of the Radiosrugery Guidelines Committee, 2005. www.guidelines.gov, and www.irsa.gov

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http://www.irsa.gov/

http://www.guidelines.gov/



Name: Sue Challinor, M.D.Section: Internal Medicine, Endocrinology____________________________________________________________________________


I. AttendingA. Outpatient

1. UPMC-Internal Medicine Residents Weekly UPMC-CDE2. Endocrinology Fellow Weekly UPMC-CDE3. Nurse Practitioner Weekly UPMC-CDE

B. Consult Service2. Subspecialty (Endocrinology) One/Mo. 2004 PUH/Montefiore/VA

C. Others (specify) None

II. Lecture/Seminar

A. Residents Noon Patient Management Conference on Cushings Syndrome and Pituitary Adenomas

B. Students 2 – two hour long PBL sessions for the Endocrinology course for the 2nd year Medical School Curriculum

2 hour long lectures on Pituitary Disease and Cushings Syndrome/Adrenal Insufficiency – Oct-Nov 2004 for Endocrine Disorders Course

C. Fellows Endocrine Summer Lecture Series: Cushings Syndrome, Aug 2004

D. Others: Pituitary Conference – a multidisciplinary conference for Endocrinology fellows, faculty and neurosurgery residents and faculty – 3 sessions/year

University-Wide Endocrine Conference: The Utility of Gamma-Knife in the Treatment of Pituitary Tumors- The Pittsburgh Experience, Feb 2005

III. UPMC Medical Grand Rounds None

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IV. Affiliated Hospital Program None

V. UPMC Medical Grand Rounds None

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2004-2005

Name: Frederick R. DeRubertis

Title: Professor of MedicineVice Chair, Department of MedicineCo-Director Fellowship Training Program in Endocrinology, Diabetes, MetabolismChief Medicine, VA Pittsburgh Healthcare System


Honors: None

Committees:

a. National: None

b. University:(1) Co-Director, Endocrine Disorder Course – PMS II Class(2) Dean’s Committee, VA Medical Center, School of Medicine, University of Pittsburgh

c. Hospital:None at PUH/MUH

d. Departmental:(1) Chairman, Committee for Promotion and Appointments, Department of

Medicine, University of Pittsburgh

(2) House Staff Selection Committee, Department of Medicine, University of Pittsburgh

(3) House Staff Competence Committee, Department of Medicine, University of Pittsburgh

(4) Curriculum Committee, Fellowship Training Program, Endocrine Division, UPMC

(5) Endocrine Fellow Selection Committee, Endocrine Division, UPMC

(6) Co-Director Endocrine Fellowship Program

e. Veterans Hospital:(1) Chief, Medical Service

(2) Medical Executive Board

(3) Executive Leadership Board

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(4) Adverse Events and Procedure Review

(5) Professional Standard Board, VAPHS

(6) Acute Care Task Force, VISN 4, VA

(7) Residency Review Committee, VAPHS, Chair

(8) Multiple ad hoc VA Committee Assignments

Invited Lectures, Seminars: None

Editor, Associate Editor:Associate Editor, Metabolism.

Ad hoc reviewer for: Kidney International, Journal American Society of Nephrology, Metabolism, Journal of Clinical Investigation, Diabetes, American Journal of Medicine

Research Topics:a. Role of reactive oxygen species/oxidant stress in diabetic nephropathy.b. Role of nitric oxide in the pathogenesis of diabetic nephropathy.c. Control of mesangial cell matrix protein production.


a. Active Direct Costs1. VA Merit Award (DeRubertis) 03/01/01-2/28/06 $764,700

Effects of Altered Superoxide Dismutase Activity on Diabetic Nephropathy.b. Pending


a. Manuscripts

Published:

1. DeRubertis,FR, Craven,PA, Melhem,MF; Salah,EM. Attenuation of Renal Injury in db/db Mice Overexpressing Superoxide Dismutase: Evidence for Reduced Superoxide-Nitric Oxide Interaction. Diabetes 53:762-768, 2004.

b. Submitted

1. DeRubertis,FR, Craven,PA, Melhem, M. Accelerated Renal Injury in Diabeteic Mice with Superoxide Dismutase Deficiency.

2.DeRubertis,FR and Craven,PA. Oxidative and Glycooxidative Stress in Diabetic Nephropathy.

c. Abstracts: None

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Name: Frederick R. DeRubertis, M.D.

Section: Internal Medicine, Endocrinology Type of Activity Date(s) Location/Course

I. AttendingA. Endocrine In-patient Consult/ Jan, 2005 PUH/MUH/VA/WPIC Teaching Rounds

B. Endocrine Fellow Weekly VA Clinic Each Monday 2 Endo Fellows/Week(0.5 day)

C. Teaching In-Patient Attending May, 2005 VAPHS For General Medicine Wards

II. Lecture/Seminar

A. Adrenal Cortex - Lecture Nov, 2004 Endo Disorders Course-PMS II Class

B. Mineralocorticoids - Lecture Nov, 2004 Endo Disorders Course-PMS II Class

C. PBL Facilitator Nov 2004 Four sessions in Endocrine Disorders Course – PMS II Class

D. Workshop on the Adrenal Nov 2004 Endo Disorders Course – PMS II Class

E. Paraneoplastic Syndromes May, 2004 Host Defense Course–PMS II Lecture

F. Misc. lectures and presentations Throughout Resident Noon Cnferences,to Endo Fellows, Medical Residents year Chief Conferences, Endo Fellow

Summer Lecture Series, Others

III. UPMC Medical Grand Rounds - None

IV. Affiliated Hospital Program -Medical Grand Rounds Oct, 2004 Mercy Hosp, Pgh, PA

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Primary Hyperaldosteronism

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2004 - 2005

Name: Adolfo Garcia-Ocaña, PhD

Title: Assistant Professor of MedicineAssistant Professor of Cell Biology and Physiology (secondary appointment)


Honors: Editorial Board, Endocrinology, 2001-2004Senior Vice-Chancellor’s Research Seminar, July 9th 2004Invited Course Speaker, European Renal Association/European Dialysis and Transplant

Association, Tenerife, Spain, October 2nd 2004.

Committees:

a. National: Noneb. University: Nonec. Hospital: Noned. Departmental: Endocrine Research Conference Co-Coordinator.e. Veterans Hospital:None


a. July 9, 2004. Senior Vice Chancellor’s Research Seminar. “Unraveling the Physiology and Therapeutic Potential of HGF in the Pancreatic Beta Cell”. University of Pittsburgh.

b. October 1, 2004. “The Future of Islet Transplantation”. Inaugural Conference of the Clinical Research Conference Series for the Academic year 2004-2005, Canary Islands General University Hospital, Tenerife, Spain.

c. October 2, 2004. CME Course: Genetics in renal transplantation held by EDTA/ERA (European Renal Association/European Dialysis and Transplant Association). Conference: “Gene- and Cell-Based Therapeutics for Type I Diabetes Mellitus”. Tenerife, Spain.

Editor, Associate Editor:

Editor -- None Associate Editor—NoneEditorial Boards-- Endocrinology 2001-2004.

Research Topics:

a. Gene therapy approaches to improve islet transplantation.d. Physiologic and therapeutic effects of hepatocyte growth factor on the pancreatic beta cell.e. Physiologic and therapeutic effects of hepatocyte growth factor on renal growth and

development.

25



1. Junior Faculty Award (Garcia-Ocaña) ADA 1/1/02-12/31/04 $120,000/yr“Transcriptional regulation of insulin, Glut-2 and glucokinase genes by hepatocyte growth factor in islet beta cells”.

2. R-01-DK 067351-01 (Garcia-Ocaña) NIH/NIDDK 3/1/04-2/28//09 $143,500/yr“Hepatocyte Growth Factor and the pancreatic beta cell”.

3. R-21-DK 068836-01 (Garcia-Ocaña) NIH/NIDDK 7/1/04-6/30/06 $125,000/yr“Protein Kinase B/Akt in the human islet”

4. R-01-DK 51081-04 (Stewart) NIH/NIDDK 7/1/96-3/31/08 $256,000/yr“Pathophysiology of PTH-related protein (1-36) in humans”

5. R-33 066127 (Stewart) NIH/NIDDK 10/1/03-9/30/06 $500,000/yr“Islet Allograft Gene Therapy in Diabetes”

6. No # (Stewart Project 2 PI) JDRF 10/1/99-9/30/04 $200,000/yr“Viral Gene Delivery of Islet Growth Factors”

Pending: None


a. Manuscripts

Published:

1.Fiaschi-Taesch N.M., Santos S., Reddy V., Van Why S., Phillbrick W.F., Ortega A., Esbrit P., Orloff J.J., Garcia-Ocaña A. Prevention of acute ischemic renal failure by targeted delivery of growth factors to the proximal tubule in transgenic mice: The efficacy of HGF and PTHrP. J. Am. Soc. Nephrol. 15:112-125, 2004.

2.Lopez-Talavera J-C., Garcia-Ocaña A., Sipula I., Takane K.K., Cozar I., Stewart A.F. Hepatocyte Growth Factor Gene Therapy for Pancreatic Islets: Reducing the Minimal Requisite Islet Transplant Mass in a Glucocorticoid-free Rat Model of Allogeneic Portal Vein Islet Transplantation. Endocrinology 145:467-474, 2004.

3. Fujinaka Y., Sipula D., Garcia-Ocaña A., Vasavada R.C.. Characterization of mice doubly transgenic for parathyroid hormone-related protein and murine placental lactogen: a novel role for placental lactogen in pancreatic beta cell survival. Diabetes 53:3120-3130, 2004.

4. Rao P., Cozar I., Roccisana J., Vasavada R.C., Garcia-Ocaña A. Hepatocyte growth factor gene therapy for islet transplantation. Expert Opinion on Biological Therapy 4:507-518, 2004.

5.Garcia-Ocaña A . Protein kinase B/Akt and the pancreatic beta cell. Cellscience Reviews 1(3):36-43, 2005.


1. Rao P., Roccisana J., Takane K. K., Bottino R., Zhao A., Trucco M., García-Ocaña A. Gene

26

Transfer of Constitutively Active Akt Markedly Improves Human Islet Transplant Outcomes in Diabetic SCID Mice. Diabetes, in press, 2005.

2. Roccisana J., Reddy V., Vasavada R. C., Gonzalez-Pertusa J. A., Magnuson M. A., and Garcia-Ocaña A. Targeted inactivation of HGF receptor, c-met, in beta cells leads to defective insulin secretion and Glut-2 downregulation without alteration of beta cell mass. Diabetes, in press, 2005.

3. Horwitz M.J., Tedesco M.B., Sereika S.M., Syed M.A., Garcia-Ocaña A., Bisello A., Hollis B.W., Rosen C.J., Wysolmerski J.J., Dann P., Gundberg C.M., Stewart A.F. Continuous infusion of parathyroid hormone versus parathyroid hormone-related protein in humans: discordant effects on 1,25(OH)2 vitamin D and prolonged suppression of bone formation. J Bone Miner Res. (in revision) 2005.

4. Horwitz M.J., Tedesco M.B., Sereika S.M., Garcia-Ocaña A. , Bisello A., Hollis B.W., Gundberg C.M., Stewart A.F. Safety and Tolerability of Subcutaneous PTHrP(1-36) in Healthy Human Volunteers: A Dose Escalation Study. J Bone Miner Res. (in revision) 2005.

b. Abstracts: Three

27



Name: Adolfo Garcia-Ocana, PhDSection: Endocrinology Type of Activity Date(s) Location/Course



C. Consult Service1. General Medicine2. Subspecialty (Endocrinology)

D. Student Tutor E. 2nd Year Clinical TutorF. Others (specify) 2004-2005 Research Advisor: P. Rao, MD; J.A.

Gonzalez-Pertusa, PhD.II. Lecture/Seminar

A. For Residents 07/04 Introduction to Core Research Techniques: “The characterization and manipulation of DNA in vitro”.

B. For Students

C. Others


IV. Affiliated Hospital Program

28


2004 - 2005

Name: Bret H. Goodpaster, PhD

Title: Assistant Professor of Medicine; Adjunct Assistant Professor of Health and Education Recreation


Honors: Study section member, ad hoc, NIH/NIDDK March 22-24, 2004.Study section member, ad hoc, NIH/EDCA June 21-22, 2004.Study section member, ad hoc, NIH/NCAM November 3-4, 2004.Invited Symposium Speaker, American Geriatrics Society, Baltimore, 2004.Invited Symposium Speaker. American College of Sports Medicine. Indianapolis. 2004.Invited Symposium Speaker, Geriatrics Society of America, Washington D.C., 2004.Invited Symposium Speaker. American College of Sports Medicine. Nashville. 2005.Invited Speaker, Advances for the Treatment of Obesity, Albuquerque. 2004.Obesity Nutrition Research Center Grants Review Committee, 2004-2005.

Committees:

a. National: None

b. University: General Clinical Research Center Advisory CommitteeMagnetic Resonance Research Center Advisory CommitteeCo-director, Energy Balance Core of the Obesity Nutrition Research Center

c. Hospital: None

d. Departmental: Endocrinology Division Website Committee



a. February 27, 2004. Invited Speaker. Advances in the Treatment of Obesity, “Treatment of Obesity: Exercise, Weight Loss and Insulin Resistance.” Albuquerque, NM.

b. January 28, 2004. Invited Symposium Speaker. “Skeletal Muscle Mass and Quality as Contributors of Frailty.” American Geriatrics Society, Baltimore, MD.

c. June 2, 2004. Invited Symposium Speaker. “Interactions between Physiology and Exercise Related to Obesity.” American College of Sports Medicine. Indianapolis, IN.

d. June 3, 2004. Invited Symposium Speaker. “Physical Activity, Intramuscular Fat, and Insulin Resistance.” American College of Sports Medicine. Indianapolis, IN.

e. May 21, 2004. Obesity Center Conference. “Regional Fat Distribution and the Metabolic

29

Syndrome.” Saint Luke’s – Roosevelt Hospital Center Columbia University College of Physicians & Surgeons. New York, NY.

f. November, 2004. Invited Symposium Speaker. “Muscle fat infiltration as a marker of muscle quality in older adults.” Geriatric Society of America. Baltimore, MD.

g. February 17, 2005. Invited Speaker. “Muscle lipid accumulation and insulin resistance: What is the role of mitochondria and exercise?” National Institutes of Health, Phoenix, AZ.

h. March 17, 2005. University of Pittsburgh Endocrinology and Metabolism Research Conference. “Insulin Resistance and Type 2 Diabetes in Aging.”

i. March 14, 2005. Invited Speaker, Endocrine Grand Rounds. “Skeletal Muscle Lipid Accumulation: An Important Link Among Fitness, Fatness, and Insulin Resistance?” University of Oregon Health Sciences, Portland, OR.

j. March 14, 2005. Invited Speaker, Portland Bone Club Seminar. “Sarcopenia and Skeletal Muscle Quality in Older Men and Women: Implications for Frailty and Fracture.” University of Oregon Health Sciences, Portland, OR.

k. March 30, 2005. Invited Speaker. “Insulin resistance and type 2 diabetes in aging: What is the role of muscle lipid and mitochondria function?” John Pierce Laboratory, Yale University, New Haven, CT.


Editor -- none

Associate Editor – Journals of Gerontology Medical Sciences, 2005; Medicine and Science in Sports

and Exercise, 2005

Editorial Boards-- Diabetes Forecast

Reviewer for:The Lancet, Diabetes, Diabetes Care, Journal of Clinical Endocrinology and Metabolism, American Journal of Clinical Nutrition, American Journal of Physiolog,, Journal of Applied Physiology, Obesity Research, Metabolism, Medicine and Science in Sports and Exercise, Journal of the American Geriatrics Society, Journals of Gerontology, 2004-2005.

Research Topics:

a. Skeletal muscle composition in obesity, type 2 diabetes, and agingb. In vivo substrate metabolism in obesity, type 2 diabetes and agingc. Effects of exercise training on skeletal muscle metabolism in obesity and in the elderlyd. Muscle structure and function in aging and in patients with osteoarthritis

30


a. Active Direct Costs

1. R01 AG20128-01(Goodpaster) NIH/NIA 7/04-06/08 $880,000Muscle Lipid and Insulin Resistance in Aging

2. Clinical Research Award(Goodpaster) ADA 1/04-1/07 $260,871Skeletal Muscle Lipid and Insulin Resistance: Effects of Physical Activity and Weight Loss

3. N01-AG-6-2101 (Newman) NIH/NIA 3/96-11/07 $25,333Dynamics of Health, Aging and Body Composition (Health ABC) – Field Center

4. R01 AG021024-01 (Ferrell) NIH/NIA 3/03-2/98 $56,295Genetic Epidemiology of Musculoskeletal Aging

5. R01 HL70257-01A1 (Jakicic) NIH 1/03-12/06 $22,518Effects of Exercise on Prevention of Weight Gain

6. P30 DK46204 (Kelley) NIH/NIDDK 4/03-3/08 $56,295Obesity Nutrition Research Center

7. N01-AR-2-2260 (Kwoh) NIH/NIAMS 7/02-05/09 $19,703Osteoarthritis Initiative – Clinical Center

8. Experimental and Applied Sciences (Goodpaster) 4/04-9/05 $121,520The Effects of Exercise Training and Dietary Supplementation on Fat Metabolism and BodyComposition in Obese Women

9. U01-AG022376-01 (Newman) NIH/NIA 7/03-09/07 $33,777Exercise to Prevent Disability Pilot Study

b. Pending

1. ADA Program Project Grant (Goodpaster) ADA 1/06-12/07 $347,826Linking Mitochondrial Function to the Prevention


a. Manuscripts

Published:

1. Goodpaster BH, Stenger A, Boada F, McKolanis T, Davis D, Ross R, Kelley D: Skeletal Muscle Lipid Concentration Quantified by MRI. American Journal of Clinical Nutrition, 79:748-754, 2004.

2. Ruhl CE, Everhart JE, Ding J, Goodpaster BH, Kanaya AM, Simonsick EM, Tylavsky FA, Harris TB, Health A, Body Composition S: Serum leptin concentrations and body adipose

31

measures in older black and white adults. American Journal of Clinical Nutrition 80:576-583, 2004

3. Holvoet P, Kritchevsky SB, Tracy RP, Mertens A, Rubin SM, Butler J, Goodpaster BH, Harris TB: The metabolic syndrome, circulating oxidized LDL, and risk of myocardial infarction in well-functioning elderly people in the health, aging, and body composition cohort. Diabetes 53:1068-1073, 2004

4. Kanaya AM, Harris T, Goodpaster BH, Tylavsky F, Cummings SR: Adipocytokines attenuate the association between visceral adiposity and diabetes in older adults. Diabetes Care 27:1375-1380, 2004

5. He J, Goodpaster BH, Kelley DE: Effects of weight loss and physical activity on muscle lipid content and droplet size. Obesity Research 12:761-769, 2004

6. Pruchnic R, Katsiaras A, He J, Kelley DE, Winters C, Goodpaster BH: Exercise training increases intramyocellular lipid and oxidative capacity in older adults. Am J Physiol Endocrinol Metab 287:E857-E862, 2004

7. Kanaya AM. Fyr CL. de Rekeneire N. Shorr RI. Schwartz AV. Goodpaster BH. Newman AB. Harris T. Barrett-Connor E. Predicting the development of diabetes in older adults: the derivation and validation of a prediction rule. Diabetes Care. 28(2):404-8, 2005

8. Ritov VB. Menshikova EV. He J. Ferrell RE. Goodpaster BH. Kelley DE. Deficiency of subsarcolemmal mitochondria in obesity and type 2 diabetes. Diabetes. 54(1):8-14, 2005

9. Katsiaras A, Newman AB, Kriska A, Brach J, Krishnaswami S, Feingold E, Kritchevsky SB, Li R, Harris TB, Schwartz A, and Goodpaster BH. Skeletal Muscle Fatigue, Strength and Quality in the Elderly: The Health ABC Study. J Appl Physiol, Feb 2005.

10. Menshikova EV, Ritov VB, Toledo FGS, Ferrell RE, Goodpaster BH, and Kelley DE.Effects of Weight Loss and Physical Activity on Skeletal Muscle Mitochondrial Function in Obesity. Am J Physiol Endocrinol Metab, Dec 2004.

11. Goodpaster, BH, Wolf D: Skeletal muscle lipid accumulation in obesity, insulin resistance and type 2 diabetes. Pediatric Diabetes 5:219-226, 2004.


1. Goodpaster BH, Krishnaswami S, Harris T, Katsiaras A, Kritchevsky S, Simonsick E, Nevitt M, Holvoet P, Newman A: Regional Body Fat Distribution and The Metabolic Syndrome in Older Men and Women. Archives of Internal Medicine, In Press.

2. Menshikova EV, Ritov VB, Fairfull L, Ferrell RE, Kelley DE and Goodpaster BH.Effects of Exercise on Subsarcolemmal and intermyofibrillar mitochondria in human skeletal muscle. Journal of Gerontology Biological Sciences, In Review.

3. Fleet, S, Wolf, D, Katsiaras, A, Goss, F, Jakicic, J and Goodpaster, BH. Substrate Oxidation during Exercise in Overweight and Normal Weight Women. Medicine and Science in Sports and Exercise, submitted.

32

4. Goodpaster BH, Brown NF: Exercise and the Role of Muscle Triglyceride in Obesity, Insulin Resistance and Type 2 Diabetes. Exercise & Sport Sciences Reviews, In Press.

b. Abstracts: Six.

33



Name: Bret H. Goodpaster, Ph.D.Section: Endocrinology Type of Activity Date(s) Location/Course

I. AttendingA. Inpatient General Medicine NoneB. Outpatient


C. Consult Service1. General Medicine2. Subspecialty (Endocrinology) None

D. Student Tutor E. 2nd Year Clinical TutorF. Others (specify) Research Advisor:

Carena Winters PhD. Dissertation: “Substrate Availability and Utilization During Exercise in the Elderly” Completed December 2004. Role: Research advisor and committee chair.Andy Katsiaras PhD, Dissertation: “Effects of Exercise Training on Skeletal Muscle Lipid Content and Insulin Sensitivity in the Elderly” Completed December 2003. Role: Research advisor and committee chair.Sara Fleet, Masters degree candidate, Thesis: “The effects of resistive or aerobic training on fat metabolism in obese women” Completed May 2004. Role: Research advisor and committee chair.Donna Wolf, PhD candidate.John Dube, Post-doctoral Fellow. Project, “Effects of exercise and weight loss on lipid accumulation in human skeletal muscle.” Role: Mentor.

II. Lecture/Seminar

A. For Residents None

B. For Students Exercise in Obesity and Type 2 Diabetes Mellitus, Graduate Course, School of Health and Recreation Education: Summer terms 2004.

Skeletal Muscle Biochemistry, GraduateCourse, School of Health and Recreation Education: Summer terms 2005.

Exercise, Obesity and Diabetes, Graduate

34

Course, School of Health and Recreation Education: Summer terms 2004.

C. Others Introduction to Core Research Techniques, Division of Endocrinology, 2004 and 2005.

School of Health Education: Two lectures

Graduate School of Public Health: Two lectures

Miscellaneous Lectures to Adult Endocrinology and Geriatric Medicine Conferences.

III. UPMC Medical Grand Rounds None.

IV. Affiliated Hospital Program March 4, 2004. Outreach Lecture, Brownsville, Hospital

35


2004 - 2005

Name: Susan L. Greenspan, MD

Title: Director, Osteoporosis Prevention and Treatment CenterProfessor of MedicineAssociate Program Director, General Clinical Research Center

Section: Endocrinology / Geriatric Medicine

Honors: Invited speaker, Plenary Session, Annual Meeting of the American Society for Bone and Mineral Research, Seattle, Washington, 2004

America’s Top Doctors, 2004Who’s Who in Medicine and Healthcare, 2002-Council Member, American Society for Bone and Mineral Research, 2002-Co-Editor, Osteoporosis: Clinical Updates, National Osteoporosis Foundation, 2002-

2004Coordinating Author, Surgeon General’s Report on Osteoporosis, 2002-2004Editorial Board, Journal of Clinical Endocrinology and Metabolism, 2001-Board of Trustees, International Society for Clinical Densitometry, 2001-2004Editorial Board, Journal of Gerontology: Medical Sciences, 1999-Editorial Board, Journal of Clinical Densitometry, 1998-Best Doctors in America, U.S. News and World Report, 1998-00, 2002-Editorial Board, Journal of Bone and Mineral Research, 1996-

Committees:

a. National: Member, Expert Blue Ribbon Panel, U.S. Administration on Aging, Whole Woman Strategy and Action Plan to Raise Awareness About Osteoporosis, 2004-

Nomination Committee, American Society for Bone and Mineral Research, 2004

Chair, Osteoporosis Pathophysiology Section, Scientific Program Committee, American Society for Bone and Mineral Research, 2004

Session Chair, Annual Meeting of the American Society for Bone and Mineral Research, 2004

Vice Chair, Professional Practice and Policy Subcommittee, Scientific Advisory Board, National Osteoporosis Foundation, 2002-2004

Scientific Advisory Council, International Society for Clinical Densitometry, 2001-

Scientific Advisory Board, National Osteoporosis Foundation, 1995-2004Mid-Atlantic Osteoporosis Board, 2000-

36

b. University: Multidisciplinary Advisory Committee, K12 Clinical Research Scholars Program, Department of Medicine, 2004-

Standing Committee for Non-Tenured Faculty Promotions and Appointments, Department of Medicine, 2001-2004

Chair, Education Subcommittee, General Clinical Research Center, 2001-Institutional Data and Safety Monitoring Board Subcommittee, 2001-

Scientific Advisory Committee, General Clinical Research Center, 1999-Prevention Task Force, School of Public Health, 1999-

c. Hospital: Clinical Research Steering Committee, 1999-

d. Departmental: Geriatric Fellowship Selection Committee, 2002-

Committee on Women’s Status at the University of Pittsburgh, Department of Medicine, 2000-

Endocrinology Fellowship Selection Committee, 1999-

Internal Medicine Residents Selection Committee, 1999-



a. July 7, 2004. “The Impact of Androgen Deprivation Therapy on Bone Loss in Men with Prostate Cancer,” Pittsburgh, PA

b. July 30, 2004. “Advances in Osteoporosis,” Fellows Conference, Division of Endocrinology and Metabolism, University of Pittsburgh, Pittsburgh, PA

c. August 5, 2004. “Bone Loss Following Chemotherapy in Women with Breast Cancer,” Pittsburgh, PA

d. August 19, 2004,” Steroid-Induced Bone Loss,” Pittsburgh, PAe. October 2, 2004. “Anabolic Treatment for Osteoporosis,” Plenary Session, Annual Meeting

of the American Society for Bone and Mineral Research, Seattle, WAf. October 3, 2004. “”Combination Therapy with PTH and Antiresorptives,” NPS

Pharmaceuticals Symposium, Annual Meeting of the American Society for Bone and Mineral Research, Seattle, WA

g. October 3, 2004. “Combination Therapy Roundtable,” Annual Meeting of the American Society for Bone and Mineral Research

h. November 3, 2004. “Combination Therapy with Parathyroid Hormone,” Endocrine Grand Rounds, University of California, San Francisco, CA

i. November 3, 2004. “Osteoporosis in Men,” Endocrine Metabolism Noon Conference, VAMC, San Francisco, CA

j. November 3, 2004, Endocrine Fellow Cases, University of California, San Francisco, CAk. November 9, 2004. “Osteoporosis,” Problem Based Learning Module, Division of

Endocrinology and Metabolism, University of Pittsburgh, Pittsburgh, PAl. November 13, December 7 and 14, 2004. “Clinical Skills Course,” Department of Medicine,

University of Pittsburgh, Pittsburgh, PA

37

m. December 10, 2004. “Dual X-ray Absorptiometry,” Case Based Learning Module, Division of Endocrinology and Metabolism, University of Pittsburgh, Pittsburgh, PA

n. February 28, 2005. “Head to Head Comparisons of Antiresorptive Therapies,” Pittsburgh, PA

o. March 28, 2005. “Osteoporosis,” Montefiore Hospital Housestaff, University of Pittsburgh Medical Center, Pittsburgh, PA

p. March 30, 2005. “Surrogate Markers for Fracture Reduction,” Pittsburgh, PAq. April 8, 2005. “Osteoporosis Update,” 13th Annual Clinical Update in Geriatric Medicine,

University of Pittsburgh, Pittsburgh, PAr. April 9, 2005. “Bisphosphonates: What We Know and Don’t Know,” 6 th International

Symposium on Osteoporosis, National Osteoporosis Foundation, Washington, DCs. June 17, 2005. “Combination Therapy for Osteoporosis,” University-Wide Endocrine

Conference, University of Pittsburgh, Pittsburgh, PA


Co-Editor

--Osteoporosis: Clinical Updates, National Osteoporosis Foundation

Editorial Boards--Journal of Bone and Mineral Research--Journal of Clinical Endocrinology and Metabolism--Journal of Clinical Densitometry--Journal of Gerontology: Medical Sciences--Osteoporosis: Clinical Updates, National Osteoporosis Foundation

Research Topics:

a. Osteoporosis in elderly men and womenf. Combination therapy for the treatment of osteoporosisg. Osteoporosis in men with prostate cancerh. New assessments of bone density and rate of bone loss in elderly women



1. M01 RR00056-42 NIH/NCRR 12/03-11/08 $212,670(Levine, PI – Greenspan, Assoc. Program Director)General Clinical Research Center, University of Pittsburgh

2. N01 AR-9-2245 (Black) NIH/NIAMS 10/99-10/05 $572,731PTH and Alendronate in Combination in the Treatment of Osteoporosis

3. R01 DK61536-03 (Greenspan) NIH/NIDDK 12/02-11/06 $740,000Prevention of Osteoporosis in Men with Prostate Cancer on Androgen Deprivation Therapy(POP Study)

4. K24 DK062895-02 (Greenspan) NIH/NIDDK 1/03-11/07 $650,714Osteoporosis in Older Men and Women

38

5. P30 AG024827-02 (Greenspan, Core PI) NIH/NIA 9/04-5/09 $79,765Pittsburgh Older American Independence Center

6. Pharmaceutical Study (Greenspan) Aventis Pharm. 11/02-6/07 $34,945The Effect of Bisphosphonate on Bone Mass, Bone Turnover and Bone Mineral Metabolism in Premenopausal and Newly Postmenopausal Women with Breast Cancer Following Chemotherapy

7. FACT Study (Greenspan) Merck & Co 9/02-8/05 $61,251A Randomized Double-blind, Double-dummy, Parallel Group, Multicenter Study to Evaluate and Compare the Effects of Once Weekly Alendronate and Risedronate on Bone Mineral Density in Postmenopausal Women with Osteoporosis

8. Pharmaceutical Study (Greenspan) Novartis Pharm. 9/03-3/06 $60,000The Impact of Prostate Cancer on Skeletal Health in Men

9. Pharmaceutical Study (Greenspan) Aventis Pharm. 3/04-2/06 $34,080Open-Label Study to Determine How Prior Therapy with Risendronate or Alendronate in Postmenopausal Women with Osteoporosis Influences the Clinical Effectiveness of Teriparatide

10. Pilot Award (Greenspan) UPCI 5/04-5/06 $25,000(Univ. of Pittsburgh Cancer Institute)Genetic Determinants of the Response to Osteoporosis Treatment in Men with Prostate Cancer on Androgen Deprivation Therapy

11. Aging Pilot Award (Greenspan) UPCI 8/04-7/06 $25,000(Univ. of Pittsburgh Cancer Institute)Genetic Determinants of Bone Loss in Men with Prostate Cancer

12. Pharamceutical Study (Greenspan) Aventis 2/05-1/06 $26,485The Effect of High Impact Exercise on Skeletal Integrity in Master Athletes

b. Pending

1. Competitive Medical Research Fund UPMCHS 5/05-4/06 $25,000Effect of Lower Extremity Loading on Bone Density and Muscular Strength in Life-Long Competitive Athletes


a. Manuscripts

Published:

1. Coates PS, Fernstrom JD, Fernstrom MH, Schauer PR, Greenspan SL. Gastric bypass surgery for morbid obesity leads to an increase in bone turnover and a decrease in bone mass. J Clin Endocrinol Metab. 89:1061-1065, 2004.

2. Rosen HN, Parker RA, Greenspan SL, Iloputaife ID, Bookman L, Chapin D, Perlmutter J, Kessel B, Qvist P, Rosenblatt M. Evaluation of ability of biochemical markers of bone turnover to predict a response to increased doses of HRT. Calcif Tissue Int. 74:415-423, 2004.

3. Luckey M, Kagen R, Greenspan S, Bone H, Kiel RD, Simon J, Sackarowitz J, Palmisano J, Chen E, Petruschke RA, De Papp AE. Once-weekly alendronate 70 mg and raloxifene 60 mg daily in the treatment of postmenopausal osteoporosis. Menopause 11:405-415, 2004.

39

4. Greenspan SL, et al. Assessing the risk of bone disease and fracture. In U.S. Department of Health and Human Services, ed. Bone Health and Osteoporosis: A Report of the Surgeon General. U.S. Department of Health and Human Services, Office of the Surgeon General, Rockville, MD, 2004, pp. 187-217.

5. Greenspan SL, et al. Prevention and treatment for those who have bone diseases. In U.S. Department of Health and Human Services, ed. Bone Health and Osteoporosis: A Report of the Surgeon General. U.S. Department of Health and Human Services, Office of the Surgeon General, Rockville, MD, 2004, pp. 219-253.


1. Greenspan SL, Resnick NM, Parker RA. The effect of hormone replacement on physical performance in community-dwelling elderly women: a randomized, controlled trial. A J Med. 2004 (in press).

2. Dacal K, Sereika SM, Greenspan SL. Quality of life in prostate cancer patients on androgen deprivation therapy. J Am Geriatr Soc. 2004 (submitted).

3.Harpavat M, Greenspan SL, O’Brien C, Chang C-C, Bowen A, Keljo DJ. Altered bone mass in children at time of diagnosis of Crohn’s disease: A pilot study. J Pediatr Gastroenterol Nutr. 2004 (submitted).

4. Greenspan SL, Resnick NM, Parker RA. Vitamin D supplementation in older women. J Gerontol: Med Sci. 2005 (in press).

5. Towers AL, Clay CA, Sereika SM, McIntosh I, Greenspan SL. Skeletal integrity in patients with nail patella syndrome. J Clin Endocrinol Metab. 2005 (in press).

6. Greenspan SL, Resnick NM, Parker RA. Early changes in biochemical markers of bone turnover are associated with long-term changes in bone mineral density in elderly women on alendronate, hormone replacement therapy, or combination therapy: a 3-year, double-blind, placebo-controlled, randomized clinical trial. J Clin Endocrinol Metab. 2005 (in press).

7. Rajakumar K, Fernstrom JD, Janosky JE, Greenspan SL. Vitamin D insufficiency in preadolescent African American children. Clin Pediatr. 2005 (in press).

8. Greenspan SL, Coates P, Sereika SM, Nelson JB, Trump DL, Resnick NM. Bone loss after initiation of androgen deprivation therapy in patients with prostate cancer. J Clin Endocrinol Metab. 2005 (submitted).

9. Greenspan SL, Beck TJ, Resnick NM, Bhattacharya R, Parker RA. The effect of hormone replacement, alendronate, or combination therapy on hip structural geometry: a 3-year, double-blind, placebo-controlled clinical trial. J Clin Endocrinol Metab. 2005 (submitted).

10. Black DM, Bilezikian JP, Ensrud KE, Greenspan SL, Palermo L, Hue T, Lang F, McGowan JA, Rosen CJ. The effect of 1 year of alendronate following 1 year of PTH 1-84: second year results from the PTH and alendronate (PaTH) trial. N Engl J Med. 2005 (submitted).

b. Abstracts: Eight

40



Name: Susan L. Greenspan, M.D.Section: Endocrinology, Geriatric Medicine Type of Activity Date(s) Location/Course

I. AttendingA. Inpatient General Medicine NoneB. Outpatient None


C. Consult Service1. General Medicine None2. Subspecialty (Endocrinology) Feb 1-28, 2005 PUH/Montefiore/VA/

MageeD. Student Tutor Cheryl Clay (MS II, Mentored Medical Student

in Clinical Research – NIH/NCRR); Kirsten Dacal (John A. Hartford American

Federation for Aging Research 2004Student Scholar);

Nicole Velez (John A. Hartford American Federation for Aging Research 2005 Student Scholar),

Amy Zhang (John A. Hartford American Federation for Aging Research 2005 Student Scholar)

E. 2nd Year Clinical Tutor NoneF. Others (specify) Fellows:

Rajib Bhattacharya (Endocrinology), Matthew Levy (Endocrinology); Julia Warren-Ulanch (Endocrinology)Junior faculty: Kumaravel Rajakumar (General Pediatrics),Manisha Harpavat (Pediatric GI); Pouran Famili (Dentistry), Cheryl Bernstein (Anesthesiology), Jean McCrory (Orthopedics), Adele Towers (Geriatric Medicine)

41

II.Lecture/Seminar

A. For Residents Miscellaneous lectures to Adult Endocrinology,Pediatric Endocrinology, General Pediatrics, Geriatric Medicine

B. For Students November, 2004 Endocrine 2nd yearcourse, 1 lecture

C. Others Miscellaneous lectures to Adult Endocrinology,Pediatric Endocrinology, General Pediatrics, Geriatric Medicine


IV. Affiliated Hospital Program Internal Medicine and Geriatric Medicine CME Courses

42


2004 - 2005

Name: Mara J Horwitz MD

Title: Assistant Professor of Medicine


Honors: CME Committee, The Endocrine Society, 2003-2006.

Committees:

a. National: CME Committee, The Endocrine Society, 2003-2006

b. University: Applicant Interviewer, Medical School Admissions CommitteeMember, GCRC Advisory CommitteeMember, ONRC Grant Advisory Committee

c. Hospital: None

d. Departmental: Member, Task Force on Women and Family Issues



1. PTHrP: Clinical Aspects. ASBMR Advances in Skeletal Anabolic Agents for the Treatment of Osteoporosis, Bethesda, MD, 2004.

2. The Temporal Profile in Humans of the Acute Skeletal Anabolic Response to Continuous, Steady-State Infusion of PTHrP and PTH. ASBMR Annual Meeting, Seattle, October 2004.


None

Research Topics:

a. Human in vivo pathophysiology of parathyroid hormone-related proteinb. Parathyroid hormone-related protein and osteoporosis therapyc. Effect of parathyroid hormone alone and in combination with a bisphosphonate, in the treatment of

postmenopausal osteoporosis.d. Effect of the SERM, Raloxifene, on heart disease in postmenopausal women with known heart

diseasee. Effect of the bisphosphonate Alendronate in the prevention of steroid-induced osteoporosisf. Effect of raloxifene compared to Alendronate in the treatment of postmenopausal osteoporosis

43

g. Effect of a once yearly infusion of a new bisphosphonate, zolendronate, in the prevention of postmenopausal osteoporotic fractures

h. Effect of a new SERM, lasofoxifene, in the treatment of postmenopausal osteoporosis


Active Direct Costs1. R01-51081 (Stewart) NIH 7/96-3/08 $297,112

Pathophysiology of PTH-related Protein(1-36) in Humans

2. Multiple Myeloma Research Foundation (MMRF) 1/04-12/07 $0(Stewart)Pure Anabolic Skeletal Therapy with PTH-related Protein for Myeloma Bone Disease

3. LY139481 (J. Cauley) Eli Lilly Co. 9/98-8/05 $47,538Raloxifene Hydrochlorid or Placebo in Postmenopausal Women at Risk for Major Coronary Events

4. LY139481 (J Cauley) Eli Lilly Co. 2/02-2/07 $47,538Raloxifene Alendronate Comparison in Postmenopausal Women with Osteoporosis

5. A2181002 (J Cauley) Pfizer 2/02-1/06 $23,769Postmenopausal Evaluation and Risk Reduction with Lasofoxifene

6. CZOL466H2301 (Cauley) Novartis 3/02-2/05 $24,957A Multicenter, Double-blind, Randomized Placebo-Controlled Study to Evaluate the Safety and Efficacy of Zolendronic Acid in the Treatment of Osteoporosis in Postmenopausal Women Taking Calcium and Vitamin D.


a. Manuscripts

Published:

1. Horwitz MJ, Stewart AF. Humoral Hypercalcemia of Malignancy. In Favus MF (ed.), Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism, Fifth Edition, The Society for Bone and Mineral Research, Washington DC, , pp.246-250.

2. Horwitz MJ, Roodman GD. Paget’s Disease of Bone. In, Andreolli TE (Ed), CECIL Essentials of Medicine, Sixth Edition. WB Saunders Company, Philadelphia, 2004, pp 723-727.

3. Bisello A, Horwitz MJ, Stewart AF. Parathyroid Hormone-related Protein: An Essential Physiologic Regulator of Adult Bone Mass. Endocrinology 145:3551-3, 2004.

4. Horwitz MJ, Tedesco MB, Sereika SM, Syed MA, Garcia-Ocana A, Bisello A, Hollis BW, Rosen CJ, Wysolmerski JJ, Dann P, Gundberg CM, Stewart AF. Continuous infusion of parathyroid hormone versus parathyroid hormone-related protein in humans: Discordant effect on 1,25(OH)2

vitamin D and prolonged suppression of bone formation. (submitted) 2005.5. Horwitz MJ, Tedesco MB, Sereika SM, Garcia-Ocana A, Bisello A, Hollis BW, Gundbert CM,

Stewart AF. Safety and Tolerability of Subcutaneous PTHrP91-36) in Healthy Human Volunteers: A Dose Escalation Study. (submitted) 2005.

b. Abstracts: 3

44



Name: Mara J Horwitz M.D.Section: Internal Medicine, Endocrinology

____________________________________________________________________________Type of Activity Date(s) Location/Course


1. Residents Weekly Clinic2. Residents Ambulatory Block 3 months Falk 2B3. Students Ambulatory Block

C. Consult Service1. General Medicine2. Subspecialty (Endocrinology) 11/04 PUH/Montefiore/VA

D. Student E. 2nd Year Clinical Tutor 1/05 -2/05 Clinical Skills II Course

(PDx III)

F. Others (specify)

II. Lecture/Seminar

A. For Residents Miscellaneous Lectures to epidemiology, orthopedics, endocrinology, and transplant

B. For Students Endocrinology Second Year Course 3 PBL sessions

C. Others Miscellaneous Lectures to epidemiology, orthopedics, endocrinology



45


2004-2005

Name: David E. Kelley

Title: Professor of MedicineDirector, Obesity & Nutrition Research Center


Honors: Member of the Metabolism Study Section NIH-NIDDK (2000-2004)American Diabetes Association, Board of Directors (2001-2005)

Committees:

a. National: Member of the Metabolism Study Section NIH-NIDDK (2000-2004)American Diabetes Association, Board of Directors (2002-2005)Chairperson, Safety Committee, NIH-NIDDK Look AHEAD TrialSteering Committee Co-Chair, NIH-NIDDK Bariatric Surgery ResearchConsortium

b. University: Member, IRBDirector, Obesity and Nutrition Research Center

c. Hospital:

d. Departmental: Co-Investigator of Endocrinology Training Grant


a. April 26, 2004 Yale University, John B. Pierce Laboratory, “Metabolic Inflexibility and the Pathogenesis of Insulin Resistance in Skeletal Muscle”

b. May 10, 2004 NIH-NIDDK, Symposium on “Obesity, Skeletal Muscle and Insulin Resistance”

c. May 26, 2004 NIH-NIA, Symposium on Biology of the Perimenopause: “Regional Adiposity and Insulin Resistance”

d. June 7, 2005 American Diabetes Association, Invited lecture, “Mitochondrial Dysfunction in Type 2 Diabetes Mellitus“

e. June 14, 2004 Endocrine Society, Invited Lecture, “Metabolic Inflexibility and Insulin Resistance“

f. August 24, 2004 Abbott Laboratory “Mitochondrial Dysfunction in Skeletal Muscle in Type 2 DM and Obesity“

g. September 23, 2004 Pittsburgh Diabetes Update “Regional Adiposity and Obesity in Type 2 Diabetes Mellitus“

h. September 28, 2004 Japan Association for the Study of Obesity, Invited lecture, “Metabolic Inflexibility and Insulin Resistance“i. November 15, 2004 North American Association for the Study of Obesity, Invited lecture

“Mitochondrial Dysfunction in Obesity“

46

j. November 18, 2004 Yale University, Endocrinology Grand Rounds: “PET Imaging of Insulin Resistance“

k. February 4, 2005 ADA Post Graduate Course, Invited lecture, “Non-alcoholic Steatohepatitis (NASH) “


Editorial Board for Diabetes, American Journal of Physiology (Endocrinology/Metabolism), Journal of Clinical Endocrinology and Metabolism.

Reviewer for American Journal of Physiology, Diabetes, Diabetes Care, Journal of Clinical Endocrinology and Metabolism, Journal of Clinical Investigation, Science, American Journal of Clinical Nutrition, Obesity Research, New England Journal of Medicine.

Research Topics:

Skeletal muscle substrate metabolism, insulin resistance; muscle mitochondrial function in insulin resistance; PET imagining, Type 2 diabetes mellitus (pathogenesis, complications and therapies); Obesity (pathogenesis, complications and therapies).


Active Direct Costs

5R01 DK060555 (Kelley) NIDDK 05/15/02-04/30/05 $881,707Multi-Tracer PET Quantitation of Insulin Action in Muscle

2P30-DK046204 (Kelley) NIDDK 9/30/97-3/31/08 $2,917,036Obesity/Nutrition Research Center

R01-DK049200 (Kelley) NIDDK 7/1/04-11/30/08 $1,100,000Mitochondrial Impairment in Muscle Insulin Resistance

5U01-DK057002 (Kelley) NIDDK 9/30/99-7/31/06 $5,222,163Action for Health in Diabetes (LOOK AHEAD)Study of Health Outcomes of Weight Loss (SHOW, Pittsburgh Site)

R01 DK60412 (Ravussin) NIDDK 9/01/01-8/31/06 $416,996Fat Cell Size, Muscle Lipid Infiltration and Insulin Resistance (Look AHEAD Ancillary Study)

R01 HL70298 (Gallagher) NHLBI 9/1/01-8/31/05 $171,732MRI Derived Organ & Tissue Mass Changes with Weight Loss (Look AHEAD Ancillary Study)

1U01-DK066585 (Courcoulas) NIDDK 9/30/03-9/29/08 $87,126Effect of Bariatric Surgery on Insulin Resistance & CVD

R01-AG023977 (Sanders) NIDDK 9/30/03-8/31/07 $50,060Obstructive Sleep Apnea (OSA) and Metabolic Syndrome: Role of Oxidative Stress

R01-HL61744 (Detre) NHLBI 9/30/00-9/29/06 $77,123

47

BARI II: A Trial of Revascularization and Glycemic Control in NIDDM7-04-MN-23 (Kelley) ADA 7/1/04-6/30/08 $180,000Mentor-Based Postdoctoral FellowshipSkeletal Muscle Insulin Resistance in Type 2 DM


a. Manuscripts

Published:

1. Kelley DE, Kuller LH, McKolanis TM, Harper P, Mancino J, Kalhan S. Effects of moderate weight loss and orlistat on insulin resistance, regional adiposity and fatty acids in type 2 diabetes mellitus. Diabetes Care 27:33-40, 2004.

2. Marroquin OC, Kip KE, Kelley DE, Johnson BD, Shaw LJ, Bairey Merz CN, Sharaf BL, Pepine CJ, Sopko G, Reis SE, Metabolic syndrome modifies the cardiovascular risk associated with angiographic coronary artery disease in women Circulation 109:714- 721, 2004

3. Kip KE, Marroquin OC, Kelley DE, Johnson BD, Kelsey SF, Shaw LJ, Rogers WJ, Reis SE Clinical importance of obesity versus the metabolic syndrome in cardiovascular risk in women. Circulation 109:706-713, 2004

4. Goodpaster BH, Stenger VA, Boada F, McKolanis TM, Davis D, Ross R, Stenger A, Kelley DE. Skeletal muscle lipid concentration quantified by MRI. American Journal of Clinical Nutrition 79:748-754 2004

5. He Jing, Goodpaster BH, Kelley DE Effects of weight loss and physical activity on muscle lipid content and droplet size. Obesity Research 12-5:761-769, 2004

6. Ritov VB, Menshikova EV, Kelley DE High-performance liquid chromatography-based methods of enzymatic analysis: electron transport chain activity in mitochondria from human skeletal muscle. Analytical Biochemistry 333:27-38, 2004.

7. Cottam DR, Mattar SG, Barinas-Mitchell E, Kuller L, Kelley DE, Schauer PR The chronic inflammatory hypothesis for the morbidity associated with morbid obesity: implications and effects of weight loss. Obesity Surgery 14:589-600, 2004

8. Heilbronn LK, Rood J, Janderova L, Albu JB, Kelley DE, Ravussin E, Smith SR, Relationship between serum resistin concentrations and insulin resistance in nonobese, obese and obese diabetic subjects. The Journal of Clinical Endocrinology & Metabolism 89: 1844- 1848, 2004

9. Fonseca,VA, Kelley DE, Cefalu W, Baron MA, Purkayastha D, Nestler JE, Hsia S, Gerich JE Hypoglycemic potential of nateglinide versus glyburide in patients with type 2 diabetes mellitus. Metabolism 53-10: 1331-1335, 2004

10. Butt AA, Fultz SL, Kwoh CJ ,Kelley DE, Skanderson M, Justice AC The risk of diabetes in HIV infected veterans the pre- and post-HAART era and the role of hepatitis C virus co- infection. Hepatology 40: 115-119, 2004

11. He J, Kelley DE, Muscle Glycogen content in type 2 diabetes mellitus. American Journal of Physiology (Endocrinology and Metabolism) 287: E1002-E1007, 2004

12. Ritov VB, Menshikova, EV, He J, Ferrell R, Goodpaster BH, Kelley DE Deficiency of subsarcolemmal mitochondria in obesity and type 2 diabetes. Diabetes 55: 8-14, 2005

13. Pruchnic R, Katsiaras A, He J, Kelley DE, Winters C, Goodpaster B Exercise training increases intramyocellular lipid and oxidative capacity in older adults. American Journal of Physiology (Endocrinology and Metabolism) 287: E857 – E862, 2004

48


1. Menshikova EV, Ritov VB, Toledo F, Ferrell R, Goodpaster B, Kelley DE Effects of weight loss and physical activity on skeletal muscle mitochondrial function in obesity. American Journal of Physiology (Endocrinology and Metabolism) 288: E000- E000, 2005

2. Bertoldo A, Price J, Mathis C, Mason S, Holt D, Kelley C, Cobelli C, Kelley DE Quantitative assessment of glucose transport in human skeletal muscle: Dynamic PET imaging of [O- Methyl – 11C]3-O-Methyl-D-Glucose. Journal of Clinical Endocrinology & Metabolism 90 (3): 0000-0000, 2005

Reviews and Chapters:

1. Kelley DE, Toledo F.G.S. “NonInvasive Imaging of Insulin Action and Resistance in Humans”. Diabetes Mellitus: A Fundamental and Clinical Text, Third Edition,. Derek LeRoith, Simeon I. Taylor, Jerrold M. Olefsky (ed.) Lippincott Williams & Wilkins, 2004

2. Kelley DE, Storlein L. “Skeletal Muscle and Obesity”. Handbook of Obesity, Etiology and Pathophysiology, Second Edition. George A. Bray, Claude Bouchard (ed): Marcel Dekker, Inc., 2004

3. Goodpaster BH, Kelley DE. “Obesity and Diabetes: Body Composition Determinants of Insulin Resistance”. Human Body Composition, 2 nd Edition , S. Heymsfield, T. Lohman, Z. Wang, and S. Going (ed). Human Kinetics. (In Press).

4. Storlien L, Oakes ND, Kelley DE, “Symposium 6: Adipose tissue-liver-muscle interactions leading to insulin resistance, metabolic flexibility” Proceedings of the Nutrition Society Gail Goldberg (ed): The Authors, 63, 363-368, 2004

5.. Kelley, DE “Influence of weight loss and physical activity interventions upon muscle lipid content in relation to insulin resistance” Current Diabetes Report, Edward S. Horton (ed): Current Science, Inc, 2004

6. Kelley, DK “Thermodynamics, liposuction and metabolism. New England Journal of Medicine: 350, 25 2542-2544, 2004

Reviews and Chapters In Press:

1. Buchwald H, O’Leary P, Billington C, Wittgrove A, Garcia V, Wolfe B, Detre K, Kelley DE, Sheldon G, Wadden T, Jensen M, Klein S Bariatric surgery for morbid obesity-2004 Consensus statement of the ASBS Consensus Conference on the state of bariatric surgery and morbid obesity: Health implications for patients, Health Professionals and third-party payers. Journal of the American College of Surgeons (In Press)

2. Toledo, FGS, Kelley, DE Mitochondrial dysfunction in the pathogenesis of insulin resistance associated with obesity, diabetes, and aging. Current Opinion in Endocrinology and Diabetes (In Press)

49



Name: David E. Kelley, M.D.

Section: Internal Medicine, Endocrinology Type of Activity Date(s) Location/Course

I. AttendingA. Inpatient General Medicine March, 2004 MontefioreB. Outpatient


C. Consult Service1. General Medicine2. Subspecialty (Endocrinology) February, 2004

D. Student Tutor E. 2nd Year Clinical TutorF. Others (specify) Research Advisor: Koichiro Azuma, MD-PhD,

Vladimir Ritov PhD, Elizaveta Menchikova PhD; Fred Toledo, MD; R. Richard Pencek, PhD Angela Jones-Leone (doctoral);

II. Lecture/Seminar

A. For Residents Intro to Research Methods for Endocrinology Fellows“Glucose Homeostasis”“Measuring Insulin Sensitivity”

B. For Students MS I “Nutrition, Obesity and Chronic Disease”MS I “Biochemical Mechanisms of the Metabolic

Syndrome”MS II “Insulin Resistance: A perspective from

clinical physiology” Intro to Research MethodsEndocrinology MSII PBL

C. Others May 14, 2004 Endocrine Grand Rounds“Pathophysiology of Adipose Tissue in Type 2 Diabetes Mellitus”February 3, 2005 Endocrine Research Conference“Triple Tracer PET Imaging of Skeletal Muscle:Isolating & Quantifying Insulin Action in Humans”

50



51


2004-2005

Name: Mary Korytkowski, MD

Title: Professor of Medicine Medical Director, Center for Diabetes and Endocrinology


Honors: Best Doctors 2003-2005

UPMC Presbyterian Presidential Performance Award for Patient Safety for Establishing Standardized Sliding Scale Regular Insulin Protocol

Committees:

a. National: BARI 2D Co-Chair Recruitment Sub-committee

b. University: Ad Hoc Committee to Review Decision regarding Promotion of a faculty member

c. Hospital: Chair Diabetes Patient Safety CommitteeUPMC Diabetes Initiative

d. Departmental: Quality AssuranceWomen’s Issues Committee

e. Division: DSMB member REBBCA Study (Susan Greenspan PI)Space Committee Meetings

Invited Lectures, Seminars: 2004August 18 Housestaff lecture - Inpatient Diabetes Management August 27 Endocrine Fellows Conference DKASeptember 24 Diabetes Prevention and Care 2004: Intervene Now

Lecture: Prevention of Type 2 DiabetesOctober 8 University of Pittsburgh Endocrine Conference

Lecture: Another form of insulin resistanceOctober 14 BARI 2D Steering Committee Progress Report from the Study Group on

Recruitment and RetentionOctober 15 Division of Endocrinology Patient Care Conference

An update on criteria for diagnosis of LOCAHNovember 18 UPMC Update in Internal Medicine

Diabetes Mellitus: What happens when the patient is hospitalizedNovember 10-11 MS2 Endocrine Disorders Course

Insulin Secretion and Replacement DKANovember 9 MS1 Cell and Tissue Physiology Course

Clinical Perspective: Endocrine Disease

52

American Diabetes Association Grand Rounds Program on Inpatient Diabetes Management 2004-2005September 29 Central Baptist Hospital Lexington KentuckyNovember 30 St. Vincent’s Hospital Birmingham AlabamaMarch 15 Bethesda North Hospital Cincinnati, Ohio

2005February 10-12 Medical Education Resources Las Vegas NV

1. Type 1 Diabetes2. Type 2 Diabetes3. Lipids, and obesity

April 8 Clinical Update in Geriatric MedicinePrevalence and Management of Diabetes in an Elderly Population

April 21 BARI 2D Steering Committee Progress Report from the Study Group on Recruitment and Retention

Research Topics:a. Optimal methods for treating hyperglycemia and heart disease in type 2 diabetesb. Quality improvement initiatives for inpatient diabetes carec. Menstrual patterns in women with diabetesd. Glycemic control in hospitalized patients receiving enteral nutritione. Etiology of androgen excess in women with PCOSf. Neurobehavioral markers for the insulin resistance syndromeg. Adherence to therapy in patients with type 2 diabetes


Active Direct Costs

1. 1R01 HL61744-02(Detre) NIH 9/01-12/07 $140,000BARI 2D

2. 5P01 HL40962-14(Manuck) NIH/NHLBI 04-05 $72,748Neurobehavioral Studies of Cardiovascular Disease

3. Pharmaceutical (Korytkowski) Pfizer 1998-2004 $156,228Atorvastatin in Primary Prevention of CHD in Type II Diabetes Mellitus

4. 5U54 HD08610-27 (Berga) NIH 2000-2005 $30,328Regulation of GNRH Drive in PCOS

5. Pharmaceutical (Korytkowski) Aventis 2005-2008 $67,790Insulin Glargine on Glycemic Control, Morbidity, and Length of Stay in Hospitalized PatientsReceiving Continuous Enteral Nutrition

6. Department of Defense (Siminerio) USAF 2004-2006 $160,128Inpatient Initiatives for Management of Patients with Hyperglycemia

7. ENHANCE Study (Sevick) NIH 2004-2006 $24,018Enhancing Adherence in Type 2 Diabetes

Pending

53

1. Department of Defense (Siminerio) USAF 2006-2007 $160,128Inpatient Initiative for Management of Patients with Hyperglycemia(Renewal)


Published:Zgibor JC, Rao H, Wesche-Thobaben J, Gallaher N, McWilliams J, Korytkowski MT. Improving the quality of diabetes care in primary care practice. J Health Care Quality 26(4):14-21, 2004.

Korytkowski MT. Sulfonylurea treatment of Type 2 diabetes: Focus on glimepiride. Pharmacotherapy 24(5):606-620, 2004.

DiNardo MM, Korytkowski MT, Siminerio LS: The importance of normoglycemia in critically ill patients. Crit Care Nursing Q 27(2):126-134, 2004.

In PressDiNardo M, Donihi A, Piatt G, DeVita M, Siminerio L, Rao H, Zewe G, Korytkowski M. A Nurse Directed Protocol for Recognition and Treatment of Hypoglycemia in Hospitalized Patients with Diabetes. ( in press Practical Diabetology)

Abstracts: One

54



Name: Mary Korytkowski M.D.Section: Internal Medicine, Endocrinology Type of Activity Date(s) Location/Course

I. AttendingA. Medicine Teaching Attending PUH

Clinical Skills Course MS2 Dec 04-Jan 05B. Outpatient

1. Residents Weekly Clinic Selected months CDE2. Residents Ambulatory Block Selected months CDE3. Students Ambulatory Block

C. Consult Service1. General Medicine2. Subspecialty (Endocrinology) April 2005

II. Lecture/Seminar

A. For Residents Lectures to Internal Medicine Residents Resident’s Conferences. Board Review: EndocrinologyInterviews of prospective internsFaculty preceptor for Senior Resident lectures

B. For Students Cell Tissue and Physiology MS1 One lecture Endocrine Disorders Course MS2 Two lectures and three PBLsInterviews of prospective medical students

C. Others Monthly Diabetes Journal ClubChief’s Conference: QI Activities,

Division of Endocrinology III. UPMC Medical Grand Rounds

IV. Affiliated Hospital Program See list of invited lectures

V. Other: Greater Pittsburgh Diabetes Club8-28-04 ADA Expo Participant in “Ask the Expert” session8-28-05 Fellow interviewsFAST AdvisorInterviews of new faculty candidates/CRNP/CDE Clinic administrator

55


2004 - 2005

Name: Haruko Akatsu Kuffner, MD

Title: Assistant Professor of MedicineDirector, Pittsburgh-Japan Program


Honors: Invited Key Note Speaker, Japan-North America Medical Exchange Foundation 2004 Annual Seminar, Tokyo, Japan 2004.Invited Symposium Speaker, Japanese Endocrine Society Annual Meeting, Tokyo, Japan 2005.

Committees:

a. National: None

b. University: None

c. Hospital: Chair, Multidisciplinary Thyroid Group

d. Departmental: Director, Pittsburgh-Japan ProgramAdvisory Board, International Scholars Program



d. July 9, 2004. Summer Lecture Series. “Synthesis and Metabolism of Thyroid Hormones.” University of Pittsburgh, Pittsburgh, PA.

e. August 12, 2004. Introduction to Core Research Techniques. “Thyroid Function Test Lab Techniques.” University of Pittsburgh, Pittsburgh, PA.

f. September 15, 2004. Multidisciplinary Thyroid Cancer Conference. “Recombinant Human Thyrotropin in the Management of Differentiated Thyroid Cancer.” University of Pittsburgh, Pittsburgh, PA..

g. October 24, 2004. Japan-North America Medical Exchange Foundation 2004 Annual Seminar. “Pros and Cons of Clinical Training in the United States.” Tokyo, Japan.

h. October 27, 2004. Muribushi Project Faculty Development Lecture Series. “What to Teach and How.” Okinawa, Japan.

i. October 27, 2004. Muribushi Project Residency Program Grand Round. “What to Learn and How.” Okinawa, Japan.

j. November 4, 2004. University of Pittsburgh Internal Medicine Noon Conference. “Interpretation of Thyroid Function Tests.” Oakland VA Medical Center, Pittsburgh, PA.

56

k. November 11, 2004. University of Pittsburgh Internal Medicine Noon Conference. “Interpretation of Thyroid Function Tests.” Presby Hospital, Pittsburgh, PA.

l. January 14, 2005. Endocrine University Wide Conference, “Papillary Microcarcinoma of Thyroid” University of Pittsburgh, Pittsburgh, PA.

m. February 15, 2005. Acute Care Nurse Practitioner Program. “Diagnosis and Management of Thyroid Disease.” University of Pittsburgh, Pittsburgh, PA.

n. July 1, 2005. Japanese Endocrine Society Annual Meeting. “Endocrine Training in the United States.” Tokyo, Japan.


None

Research Topics:Thyroid CancerInternational Medical ExchangeMedical Education


a. Activei. “Promoting International Clinical Medical Exchange and Education”

Japan-North America Medical Exchange Foundation (Kuffner, PI) 6/1/02-5/31/05

b. PendingNone


a. Manuscripts

Published:

1. Kuffner H. Introducing International Perspective in Clinical Medicine: Pittsburgh-Japan Program (in Japanese) In Studying Medicine in the US and in Canada. Haru Shobou, pp271-274, 2004.


1. Kuffner, H, McCook, BM, Swaminatha R, Myers EN, Hunt JL. Controversial Ectopic Thyroid: A Case Report of Thyroid Tissue in the Axilla and Benign Total Thyroidectomy. (Accepted for publication in Thyroid, 4.2005. Manuscript MS# 05-150R)

2. Korytkowski M and Kuffner H. Thyroid disease. In Primary Care in Obstetrics and Gynecology, (in press) 2005.

b. Abstracts: One

57



Name: Haruko A Kuffner, M.D.Section: Internal Medicine, Endocrinology Type of Activity Date(s) Location/Course


1. Fellows Weekly Clinic All year, CDE-Falk Mon am & Mon pm

2. Residents Weekly Clinic3. Residents Ambulatory Block All year CDE-Falk 4. Students Ambulatory Block

C. Consult Service1. General Medicine2. Subspecialty (Endocrinology) July, 2004 PUH/Montefiore/VA

D. Student Tutor E. 2nd Year Clinical Tutor October, 2004 Physical Diagnosis CourseF. Others (specify)

II. Lecture/SeminarA. For Residents 2 Noon Conferences for Internal Medicine Residents

B. For Students Endocrinology Second Year Course: 2 lectures, 3 PBLs

C. Others 2 Summer Lectures for Endocrine Fellows



58


2004 - 2005

Name: Gary R. Marshall, Ph.D.

Title: Associate Professor of Medicine


Honors: None

Committees:

a. National: None

b. University: Director, Endocrine Immunoassay Core Laboratory

c. Hospital: None




o. March 26-27 Seminar: The role of gonadotropins in regulation of spermatogonial proliferation and differentiation in adult rehesus monkeys. Bioqual, Inc.


Ad hoc reviewer for:Endocrinology

International Journal of AndrologyJournal of Clinical Endocrinology and MetabolismJournal of AndrologyJournal of Reproduction and FertilityEndocrineBiology of Reproduction

Research Topics:

a. Hormonal control of spermatogenesis in adult primateb. Spermatogonial proliferation and differentiation in adult primatec. Spermatogonial proliferation and differentiation in immature primated. Stem cell renewal in primate spermatogensis

59



1. R01 DK61536-01 (Dr. S. Greenspan)NIH/NIDDK 5/12/02-3/31/06 $1,191,750/yr Prevention of Osteoporosis in Men with Prostrate Cancer on Androgen Deprivation Therapy

2. R01-1-51081(Dr. A.F. Stewart) NIH/NIDDK4/1/03 3/31/08 $500,000/yrPathophysiology of PTH-Related Protein (1-360 in Humans)

3. U54HD36207 (Dr. E. Albrecht, University of Maryland) 4/1/04 - 3/31/09 $711,000/yr Specialized Co-operative Center for Reproductive Research: The Primate Male Reproductive System By Estrogen In Utero: Impact on Fertility In Adulthood.

Pending:

1. P-30 (Stewart) NIDDK 4/1/05-9/30/04 $1,000,000/yrDiabetes and Endocrine Research Center


a. Manuscripts

Published:

In Press:

Marshall GR, Ramaswamy S Plant TM. Gonadotropin independent proliferation of the pale type A spermatogonia in the adult rhesus monkey (Macaca mulatta). Biol Reprod in press

b. Abstracts: Three

60



Name: Gary R. Marshall, Ph.D.Section: Internal Medicine, Endocrinology Type of Activity Date(s) Location/Course

I. Attending Not applicable

II. Lecture/Seminar

A. For Residents None

B. For Students Human Reproduction and Human Development Third Year Course: 5 PBLs and 2 Workshops

C. Others None



61


2004-2005

Name: Robert M. O’Doherty

Title: Assistant Professor


Honors: None

Committees: a. National: NONEb. University IACUC (Institutional Animal Care and Use Committee)

Course Design Committee, Fuel Metabolism Course for MS-1c. Hospital NONEd. Departmental: Member, Division of Endocrinology Fellowship Training Grant

Executive CommitteeCourse Director, "Introduction to Core Research Techniques"

e. Veterans Hospital: NONE

Invited Lectures, Seminars:a. February, 2004, Case Western Reserve University, Cleveland, OHb. April 2004. University of North Carolina, Durham, NCc. June 2004, MERCK Research Laboratories, Rahway, NJ.d. April 2005 Columbia University, NY, NYe. May 2005. University of Colorado, Denver, CO

Editor, Associate Editor: NONE

Research Topics:

a. Mechanisms of insulin resistance in obesity/NIDDM (diabesity)b. Mechanisms of leptin resistance and leptin action in liver


Active Grant Support Direct Costs

1. ADA (O'Doherty) American Diabetes Association 1/1/05-12/31/08 $100,000/yr"Insulin resistance and the IKK/IB/NFB pathway"

Pending

1. R-O1-DK-072162-01 (O'Doherty) NIH/NIDDK 7/1/05-6/30/10 $225,000/yr"Hepatic leptin action and leptin resistance in obesity"

62

Publications for 2004/2005

a. Manuscripts

Published:1. O'Doherty, RM, Nguyen, L. Blunted fasting-induced decreases in plasma and CSF leptin

concentrations in obese rats: The role of leptin secretion and leptin gene expression. Int. J. Obesity, 28:173-175, 2004.

2. Commerford, SR, J Dubé, L Nguyen, L Peng, RM O’Doherty. Skeletal muscle SREBP1c gene expression: effects of fasting-refeeding, hyperinsulinemia, and hyperleptinemia. Am.J.Physiol. 287:R218-R227, 2004.

3. Handley, D, N Serban, D Peters, RM O'Doherty, M Field, L Wasserman, P Spirtes, R Scheines, and C Glymour. Evidence of systematic expressed sequence tag (EST) I.M.A.G.E. clone cross-hybridization on cDNA microarrays. Genomics. 83(6):1169-1175, 2004

4. Huang, W, N Dedousis, BA Bhatt, RM O'Doherty. Impaired activation of phosphoinositol 3-kinase by leptin is a novel form of hepatic leptin resistance in diet-induced obesity. J.Biol.Chem. 279:21695-21700, 2004

5. Sinha S, G Perdomo, NF Brown, RM O’Doherty. Fatty acid-induced insulin resistance in L6 myotubes requires nuclear translocation of NFB. J.Biol.Chem, 279:41294-41301, 2004

6. Perdomo, G, SR Commerford, SH Adams, RM O'Doherty, NF Brown. Increased ß oxidation in muscle cells enhances insulin-stimulated glucose metabolism and protects against fatty acid induced insulin resistance despite intramyocellular lipid accumulation. J.Biol.Chem. 279:27177-27186, 2004.


1. Bhatt B, JJ Dube, N Dedousis, J Alton-Reider, RM O'Doherty. Diet-induced obesity and acute hyperlipidemia reduce IB levels in rat skeletal muscle in a fiber-type dependent manner. Submitted.

2. Huang, W, N Dedousis, A Biyani, RM O'Doherty. Hepatic lipoprotein and lipid oxidative metabolism are rapidly altered by direct actions of leptin on liver in vivo. Submitted.

b. Abstracts: 4

63



Name: Robert M. O’Doherty, Ph.D.

Section: Endocrinology Type of Activity Date(s) Location/Course

I. AttendingA. Student TutorB. Other (Specify):

Research Advisor: Sandeep Sinha, PhD,, Bankim Bhatt, MD, Wan Huang, Ph.D. Michael Radin MD, John Dube MSc, Archana Biyani MD, Jessica Perrini, MD.

II. Lecture/SeminarA. For Students Cell Structure, Metabolism , and Nutrition: Six lectures

and two review sessions

Endocrinology, Second Year Course, one lecture

Foundations of Biomedical Science, INTBP 2000/2005. 8 PBLs

B. For Fellows Introduction to Core Research Techniques. One lecture


IV. Affiliated Hospital Programs None

64


2004-2005

Name: R. Harsha Rao, MDTitle: Professor of Medicine


Honors: Performance Award ($1200) for Performance VAPHCS, 2005Visiting Guest Professor at Keio University, Tokyo, Japan, October 2004Distinguished Teacher Award, Medical Interns, Department of Medicine, UPMC, 2004

Committees:

a. National: None

b. University: None

c. Hospital: Member, Total Quality Council, UPMCMember, Physicians Advisory Council, UPMC

d. Departmental: Co-Director 3rd Yr Medicine Clerkship, Dept of MedicineTraining Director, Fellowship Program in EndocrinologyDirector, Diabetes Service, Endocrine DivisionDirector, Billings and E&M Documentation, Endocrine DivisionMember, Morning Report FacultyFaculty Member, Pittsburgh-Japan Program

e. VA Hospital: Division Chief, Endocrinology

Invited Lectures:1. June 11, 2004, UPMC Family Practice Refresher Course, Department of Family Practice, UPMC:

“Treating to Target in Type 2 Diabetes”, Pittsburgh Convention Center, Pittsburgh, PA. 2. November 19, 2004, Update in Internal Medicine, Department of Medicine: “Sexual Dysfunction”,

Pittsburgh Convention Center, Pittsburgh, PA.

Research Topics:

a. Diabetes Outcomes Research: Impact of Diabetes on Outcomes in Acute MIb. Diabetes Outcomes Research: Glycemic Control and Macrovascular Complications in Type 2

Diabetes

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Active: 1. Principal Investigator: “Enabling outcome and process analysis in an electronic database of

patients with acute myocardial infarction in relation to diabetes.“ $30,000, 1/1/01-continuing, Siemens Corporate Research, Princeton, N.J.

2. Principal Site Investigator: VA Cooperative Study on Diabetes Control and Complications #CSP465; 2000-2007

Pending: Air Force Diabetes Initiative, 25% Salary Support


a. Manuscripts: None

66

Annual Report of Education ActivitiesDepartment of Internal Medicine


Name: R. Harsha Rao, MDSection: Internal Medicine, Endocrinology


I. AttendingA. Inpatient General Medicine NoneB. Outpatient

1. Residents Weekly Clinic Tuesday PM Falk/Endocrine rotation2. Residents Ambulatory Block Tuesday AM Falk/ Endocrine rotation

Thursday PM Falk/ Endocrine rotationMonday PM VA Diabetes clinic elective

3. Students Ambulatory BlockC. Consult Service

1. General Medicine None2. Subspecialty (Endocrinology) December 2004 PUH/Montefiore/VA

D. Student Tutor (3rd Year) Every Thursday Professor’s Rounds: MS3 Medicine Clerkship

E. 2nd Year Clinical TutorF. Others (specify):

II. Lectures/Seminars

A. For Residents Miscellaneous Lectures to Internal Medicine & Dermatology Residents, and to Pediatric Endocrinology & Adult Endocrinology Fellows.

B. For Students MS1 Course on Cell Structure, Nutrition Two lecturesAnd MetabolismMS2 Course on Endocrine Disorders Director of Diabetes sub-block

Director of the Workshop on Diabetes Complications Five lecturesTwo PBL sessions

MS4 Selective in Pharmacology One LectureOne PBL Session



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Annual ReportDepartment of Medicine

2004-2005

Name: Michelle M. Roberts, M.D.

Title: Associate Professor of MedicineCo-Director, Women’s Health Training Program, Department of Medicine

Assistant Professor of Psychiatry


Honors: Fellow, American College of Physicians

Committees:

a. National: Chair, Osteoporosis Subcommittee, American Medical Women’s Association

b. University: Faculty Advisory Committee on Continuing Medical Education, Department of Medicine representative

Dean’s Interview Committee, Medical School interviews

c. Hospital: None

d. Departmental: Co-Director, Women’s Health Track Intern Selection Committee


Monthly series: Seminars in Women’s Health, Montefiore University Hospital, Pittsburgh, PA.

Editor, Editorial Board

Editorial Board – Musculoskeletal Oncology and Metabolic Bone Disease Section of OrthopedicsToday

Reviewer for Journal of the American Medical Women’s Association

Research Topics

None

Grants/Awards/Contracts: None

68

Publications

a. Manuscripts - Noneb. Abstracts - None

69



Name: Michelle M. Roberts MD

Section: Internal Medicine, Endocrinology


I. AttendingEndocrinology Consult Service: April 2004

Department of Medicine Teaching Attending: Not required this year

Preceptor in Endocrinology Clinic: All year Endocrinology fellows – Tuesday AM Medicine and Women’s Health Track residents – Thursday – all day Women’s Health Students – Thursday mornings

II. Lecture/Seminar

A. For residents: Miscellaneous lectures to Women’s Health Track

B. For Students: Endocrinology PBL: three seminars ( Nov 9, Nov 19, and Dec 1 2004)

C. Others: Bone club presentations, Women’s Health Track Journal Club.

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2004-2005

Name: Rose Ann Salata MD

Title: Member, Division of EndocrinologyAssistant Professor of Medicine


Honors: Best Doctors in America 2003-2004

Committees: Diabetes Seminar 2004-2005, Planning Committee, Course Director

Invited Lectures, Seminars: None


Research Topics: None Grants/Awards/Contracts:

The Effect of Insulin Glargine on Glycemic Control, Morbidity, Mortality, and Hospital Length of Stay in Hospitalized Patients Receiving Enteral Nutrition , Co-Investigator. Aventis

Publications for 2004-2005: None

71



Name: Rose Ann Salata MDSection: Internal Medicine, EndocrinologyType of Activity Date(s) Location/Course

I. Attending A. Inpatient Sept, 2004 Nov, 2004B. Outpatient

1. Precept Fellows Every Tues. AM VA weekly VA Clinic2. Precept Fellow Alternate Friday PM CDE3. Precept Residents Thurs. AM CDE-Falk

Ambulatory Clinic C. Consult Service

1. Subspecialty (Endocrinology) Sept, 2004 2. Diabetes Consult Service Weekends in PUH/MUH/

Sept, Nov, 2004; WPIC/VA Feb. 4-6, 2005

II. Lecture/Seminar

A. For Residents Noon Resident Lectures

B. For Students Endocrinology Second Year CourseTwo lectures, two PBL’s, one workshop

Pharmacology Review Course – Fourth Year Students, Two lectures, One PBL.

C. For Fellows Summer Lecture Series – August, 2004

D. University Wide Endocrine Grand Rounds January 21, 2004

E. Hospital Program Thyroid Cancer Conference - March 16, 2005

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2004-2005

Name: Linda M. Siminerio, RN, PhD, CDE

Title: Executive DirectorAdult Clinical Services DivisionUniversity of Pittsburgh Diabetes InstituteAssistant Professor of MedicineAssistant Professor of Nursing


Honors: Plenary Lecture, International Diabetes Federation Congress, Paris 2003Invited Speaker, American Diabetes Association Annual Meeting, 2004

Harold Rifkin Award for Distinguished International Service in the Cause of Diabetes, 2003

Senior Vice-President, International Diabetes Federation, 2003-2006Member, Board of Management, International Diabetes Federation, 2003-2006Chancellor’s Distinguished Public Service Award, University of Pittsburgh, 2004

Committees:

a. International: American Appointee to the Diabetes Education SectionInternational Diabetes Federation

Task Force for the International Diabetes AtlasInternational Diabetes Federation

Member of the North American RegionInternational Diabetes Federation

Member of the North American Region Education CommitteeInternational Diabetes Federation

Chair of the Task Force on Publication Diabetes VoiceInternational Diabetes Federation

Member of the Strategic Planning CommitteeInternational Diabetes Federation

Membership representing North America, Planning CommitteeProgram Executive CommitteeInternational Diabetes Federation, Congress 2006

Member of the IDF/WHO work group on Health Care Delivery WorkshopInternational Diabetes Federation World Health Organization

WHO Reviewer of the World Diabetes ReportWorld Health Organization

b. National: Member, American Diabetes Association, International Task ForceMember, American Association of Diabetes Educators Research

73

CommitteeMember, Legal Advocacy Committee, American Diabetes

AssociationMember, National Diabetes Education Outcome System

Committee, American Association of Diabetes Educators

AACE, Implementation Conference for ACE Outpatient Diabetes MellitusConsensus Conference Recommendations, Washington DC

c. University: Co-Chair, Pennsylvania Statewide Diabetes Summit 2005.Course Director, “Diabetes Prevention and Care 2004: Intervene Now”

September 2004.

d. Hospital: Chair, Diabetes Advisory Committee, UPMC Health SystemDiabetes Patient Education Committee, UPMC Health SystemPatient Oversight Safety CommitteeDiabetes Committee, UPMC Health PlanOversight Committee for Diabetes Appropriation Funding

e. Departmental: None

f. Veterans Hospital:None


a. June 2004. American Diabetes Association Scientific Sessions. “Implementing the Chronic Care Model for Improvements in Diabetes Care and Education”, Orlando, FL USA.

b. August 2004. American Association oOf Diabetes Educators Annual Meeting. “Steering Toward a New DAWN in Diabetes Management: Facilitating Team Care”. Indianapolis, IN

c. Sept. 2004. UPMC Diabetes Quality Symposia. “Implementing the Chronic Care Model for Improvements in Diabetes Care and Outcomes”. Pittsburgh, PA

d. November 2003. Diabetes Attitude Wishes and Needs Summit. “The Team Approach” London, England.

e. February 2004. Presented to U.S. Army and the University of Hawaii. “Translating Genetic Information on Type 1 Diabetes to the Community”. Honolulu, HI, USA.

f. March 2004. Keynote Lecture, American Association of Diabetes Educators of St. Louis. “Diabetes Education: The Global Renaissance”. St. Louis, MO, USA.

g. May 2004. Croatian Telemedicine Meeting. “Translating Genetic Information on Type 1 Diabetes to the Community”. Zagreb, Croatia.

h. Oct., 2004. Mexican Diabetes Federation. “Diabetes Education: A Global Renaissance”, Mexico City, Mexico

i. Nov 2004. The United Nations Global Alliance for Women’s Health. “Diabetes Education and Women”. New York, New York.

j. January, 2005. American Assocication of Clinical Endocrinologists Consensus Conference. “Organizing Diabetes Education on a Large Scale: Breaking through the Barriers in Primary Care”. Washington, D.C.

k. March 2005. University of Pittsburgh Endocrine Conference. “A Chronic Care Approach for Improvements in Diabetes Care and Outcomes in UPMC Communities”.

l. April 2005. American Association Ofof Diabetes Educators DAWN Program. “Diabetes Attitude, Wishes and Needs (DAWN): The DAWN Findings”. Pittsburgh, PA

74

m. April 2005. The American Telemedicine Assoicication Annual Meeting. Using Technology in Implementing the Chronic Care Model for Improvements in Diabetes Care”. Denver, CO

75


Editor-in-Chief -- Diabetes Forecast

Research Topics:

a. Diabetes Educationb. Psychosocial and behavioral aspects of diabetesc. Diabetes program developmentd. Diabetes and telemedicine


a. Activea. Active Direct

Costs

1. 1R01 DK60586-01A1 HHS 12/01-11/06(Siminerio, Co-PI)Psychosocial Factors in Adolescent Adjustment to IDDM

2. U.S. Department of Defense (Siminerio, PI) 11/02-10/04Genetic Testing for Type 1 Diabetes in Families of Military Dependents: Translating Results from the Laboratory to the Community

3. U.S. Department of Defense (Siminerio, PI) 11/02-10/04 $800,000Administrative Core, University of Pittsburgh Diabetes Institute

4. 1T32 DK063686 (Siminerio, Co-PI) NIH/NIDDKResearch and Academic Training in Pediatric Diabetes


a. Manuscripts

Published:

1. DiNardo M, Korytkowski M, Siminerio L. “The Importance of Normoglycemia in Critically Ill Patients”. Crit Care Nurse Q 27(2):126-134, 2004.

2. Siminerio L, Zgibor J, Solano FX. “Implementing the Chronic Care Model for Improvements in Diabetes Practice and Outcomes in Primary Care: The University of Pittsburgh Medical Center Experience”. Clinical Diabetes 22(2):54-58, 2004.

3. Feathers A, Charron-Prochownik D, Siminerio L, Manthei E, Dorman J. “Genetics and Type 1 Diabetes: Online Resource for Your patients”. The Diabetes Educator 40(6): 972-979, 2004.

4. Manthei E, Siminerio L, Conley Y, Charron-Prochownik D, Feathers A, Charles B, Dorman J. “Genetics and Type 1 Diabetes: Online Resource for Diabetes Educators”. The Diabetes Educator 40(6): 961-971, 2004.

5. Siminerio L, Piatt G, Zgibor J. “Implementing the Chronic Care Model in a Rural Practice”. The Diabetes Educator 31(2), 2005.

76

In Press or Submitted:.“Implementing Diabetes Self-Management Education Programs: Breaking Through the Barriers in Primary

Care” Endocrine Practice In Press

b. Abstracts: 8

77



Name: Linda M. Siminerio, RN, PhD, CDESection: Internal Medicine, Endocrinology Type of Activity Date(s) Location/Course

I. AttendingA. Inpatient General Medicine N/A

B. Outpatient N/A1. Residents Weekly Clinic2. Residents Ambulatory Block3. Students Ambulatory Block

C. Consult Service N/A1. General Medicine2. Subspecialty (Endocrinology)

D. Student Tutor N/AE. 2nd Year Clinical Tutor N/AF. Others (specify) N/A

II. Lecture/Seminar

A. For Residents N/A

B. For Students October 2004 School of Nutrition

C. Others None

III. UPMC Medical Grand Rounds January 2004

IV. Affiliated Hospital Program UPMC McKeesport Lion’s Diabetes Center Board of Directors

78


2004-2005

Name: Maja Stefanovic-Racic, MD, PhD

Title: Instructor in Medicine


Committees:

a. Hospital: Diabetes Patient Safety Oversight Committee(Developed an inpatient protocol for continuous subcutaneous insulin pump use)


a. March 3, 2005. Endocrine Research Conference. “Beneficial Effects of Increased Hepatic Fatty Acid Oxidation.” Division of Endocrinology, University of Pittsburgh.

b. January 14, 2005. Patient Care Conference. “Just Another Diabetes Consult.” Division of Endocrinology, University of Pittsburgh.

Research Topics:

a. Hepatic fatty acid metabolism and development of fatty liver.b. Carnitine palmitoyltransferase I in human skeletal muscle.



1. K08 DK067272-02 (Stefanovic-Racic, PI) NIH/NIDDK 4/1/04-3/31/09 $126,630/yr Hepatic Fatty Acid Metabolism and Insulin Resistance


a. Manuscripts

In Preparation or Submitted:

1. Stefanovic-Racic M, Perdomo G, Sipula I and Brown NF: Overexpression of carnitine palmitoyltrasnferase I in hepatocytes decreases cellular triglyceride accumulation and secretion. (In preparation) 2005.

2. Perdomo G, Stefanovic-Racic M, Sipula I and Brwon NF: Rapamycin stimulates fatty acid oxidation and decreases lipogenesis in primary cultures of rat hepatocytes. (Submitted) 2005.

b. Abstracts

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1. Stefanovic-Racic M, Perdomo G, Sipula I and Brown NF: Overexpression of carnitine palmitoyltrasnferase I in rat hepatocytes increases free fatty acid oxidation, decreases cellular lipid content and diminishes triglyceride secretion. (Submitted for Annual Meeting of American Diabetes Association, June 2005).

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Annual Report of Educational ActivitesDepartment of Internal Medicine


Name: Maja Stefanovic-RacicSection: Internal Medicine, Endocrinology

Type of Activity Date Location/Course

I. AttendingA. Outpatient 1. Residents Ambulatory Falk Clinic

Block

B. Consult Service 1. Endocrinology October 2004 PUH/Montefiore/

WPIC/Magee

C. 2nd Year Clinical Tutor November 2004 Physical DiagnosisCourse

II. Lecture/SeminarA. For Residents March 9, 2005 “Hypoglycemia” at

UPMC-SSH Resident’s Conference

B. For Students November 2004 Endocrinology 2nd Year Course: 2 PBLs

April 2005 4th Year Clinical Pharmacology Course: 1 Lecture, 1 PBL

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2004 - 2005

Name: Andrew F. Stewart MD

Title: Chief, EndocrinologyProfessor of Medicine


Honors: Associate Editor, Journal of Bone and Mineral Research, 2003-2008Chair, Nominating Committee, The Endocrine Society, 2003-2004.Co-Chair, NIH-ASBMR Conference on Anabolic Skeletal Agents for Osteoporosis, 2004Invited Symposium Speaker, Endocrine Society Annual Meeting, New Orleans, 2004Invited Symposium Speaker, International Society for Endocrinology, Lisbon, 2004Invited Symposium Speaker, Royal Society of Medicine, London, 2004.Program Committee, International Society for Bone and Mineral Research, 2005Program Committee, American Society for Bone and Mineral Research, 2004Best Physicians in US, 2004

Committees:

a. National: Chair, Corporate Advisory Board, The American Society for Bone and Mineral Research, 2004

Medical Advisory Committee, The Paget’s Disease FoundationChair, Research Policy Committee, American Diabetes Association

b. University: Co-Director, University of Pittsburgh Diabetes InstituteCMRF Grants Review Committee

c. Hospital: Division Chief, Endocrinology

d. Departmental: Division Chief, EndocrinologyChair, Medical Grand Rounds CommitteeResearch Committee



a. July 9-10, 2004. Symposium: “PTHrP: From Hypercalcemia to Anabolic Skeletal Therapy for Osteoporosis.” Pittsburgh PTH-PTHrP Conference. Paris, France.

b. July 14, 2004. Symposium: “Growth Factor Gene Therapy and Cell Cycle Regulation in the Beta Cell of the Pancreatic Islet.” Vanderbilt University Division of Endocrinology, Nashville, TN.

c. September 3, 2004. Symposium: “The Pathophysiology of PTHrP in the Development of Humoral Hypercalcemia of Malignancy.” The International Society for Endocrinology. Lisbon, Portugal.

82

d. September 21, 2004. Medical Grand Rounds. “PTHrP: From Hypercalcemia to Anabolic Skeletal Therapy for Osteoporosis.” Northwestern School of Medicine. Chicago, IL.

e. October 7, 2004. Medical Grand Rounds. “PTHrP: From Hypercalcemia to Prevention of Artherial Re-Stenosis.” Cleveland Clinic Foundation. Cleveland, OH.

f. October 7, 2004. Endocrine Club. “PTHrP: From Hypercalcemia Anabolic Skeletal Therapy for Osteoporosis.” Cleveland Clinic Foundation. Cleveland, OH

g. October 8, 2004. Endocrine Grand Rounds. “Growth Factor Gene Therapy for Enhancing Pancreatic Islet Transplantation for Diabetes.” Cleveland Clinic Foundation. Cleveland, OH

h. November 12, 2004. “Growth Factor Gene Therapy for Enhancing Pancreatic Islet Transplantation for Diabetes.” Royal Society of Medicine, London.

i. January 20, 2005. Center for Musculoskeletal Disease Conference. “PTHrP: From Hypercalcemia Anabolic Skeletal Therapy for Osteoporosis.” Department of Pathology, University of Alabama at Birmingham, Birmingham, AL.

j. April 6, 2005. Symposium Speaker. “PTHrP from Hypercalcemia of Malignancy to Anabolic Skeletal Therapy for Osteoporosis. “ National Osteoporosis Foundation. Bethesda, MD.

k. June 29, 2005. Meet the Professor Session. “Hypercalcemia.” European Calcified Tissue Society. Geneva.


Associate Editor--American Society for Bone and Mineral Research, Primer on Metabolic Bone Diseases and

Disorders of Mineral Metabolism, First, Second, Third, Fourth, Fifth and Sixth Editions--Journal of Bone and Mineral Research 2003-2008.

Editorial Boards-- Bone

Research Topics:

a. Vascular actions of parathyroid hormone-related protein and therapy for arterial re-stenosis.b. Human in vivo pathophysiology of parathyroid hormone-related proteinc. Parathyroid hormone-related protein and osteoporosis therapyd. Physiologic and therapeutic effects of parathyroid hormone-related protein and hepatocyte growth

factor on the pancreatic islet



1. R-01-DK 51081-04 (Stewart) NIH/NIDDK 7/1/96-3/31/08 $256,000/yrPathophysiology of PTH-related protein (1-36) in humans

2. R-33 066127 (Stewart) NIH/NIDDK 10/1/03-9/30/06 $500,000/yrIslet Allograft Gene Therapy in Diabetes

83

3. No # (Stewart Project 2 PI) Pitt JDRF Center 10/1/99-9/30/04 $200,000/yrViral Gene Delivery of Islet Growth Factors

4. No # (Stewart Project 3 PI) MMRF 1/1/04-12/31/07 $120,000/yrPure anabolic skeletal therapy with PTH-related protein for myeloma bone disease.

5. T-32 DK 07052 (Stewart PI) NIH/NIDDK 7/1/00–6/30/05 $177,000/yrTraining in Diabetes and Endocrinology

Pending:

1. R-01- No Number (Stewart) NIH/NIDDK 10/1/05-9/30/08 $250,000/yrRegulation of 1,25 vitamin D and Bone Formation By PTH and PTHrP

2. Research Grant (Stewart) JDRF 1/1/05–12/31/06 $100,000/yrHGF for Pancreatic Islet Allograft in Human lslets

3. P-30 (Stewart) NIDDK 4/1/05-9/30/04 $1,000,000/yrDiabetes and Endocrine Research Center

4. T-32 DK 07052 (Stewart) NIH/NIDDK 7/1/05–6/30/10 $277,000/yrTraining in Diabetes and Endocrinology


a. Manuscripts

Published:6. Lopez-Talavera J-C, Garcia-Ocaña A, Sipula I, Takane KK, Cozar I, Stewart AF. Hepatocyte

Growth Factor Gene Therapy for Pancreatic Islets: Reducing the Minimal Requisite Islet Transplant Mass in a Glucocorticoid-free Rat Model of Allogeneic Portal Vein Islet Transplantation. Endocrinology 145:467-474, 2004.

7. Cozar-Castellano I, Takane KK, Bottino R, Balamurugan AN, Stewart AF. Induction of Beta Cell Proliferation and Retinoblastoma Protein Phosphorylation in Rat and Human Islets Using Adenoviral Delivery of Cyclin-Dependent Kinase-4 and Cyclin D1. Diabetes 53:149-59, 2004.

8. Taesch N, Takane KK, Masters S, Lopez-Talavera J-C, Stewart, AF. Parathyroid Hormone-related Protein as a Regulator of pRb and the Cell Cycle in Arterial Smooth Muscle. Circulation 110:177-85, 2004.

9. Stewart AF. Translational Implications of the Parathyroid Calcium Receptor. N Engl J. Med. 351:324-6, 2004.

10. Bisello A, Horwitz MJ, Stewart AF. Parathyroid hormone-related protein: an essential physiological regulator of adult bone mass. Endocrinology 145:3551-53, 2004.

11. Stewart AF. Normal Physiology of Bone and Mineral Homeostasis. In, Andriole TE (Ed). Cecil’s Essentials of Medicine, Saunders, Philadelphia, pp. 683-694, 2004.

12. Stewart AF. Disorders of Serum Minerals. In, Andriole TE (Ed). Cecil’s Essentials of Medicine, Saunders, Philadelphia, p. 695-707, 2004.

13. Stewart AF. Metabolic Bone Diseases. In, Andriole TE (Ed). Cecil’s Essentials of Medicine, Saunders, Philadelphia, pp. 709-714, 2004.

14. Stewart AF. Hypercalcemia Associated with Cancer. N Engl J Med 352:373-379, 2005.

84


10. Horwitz MJ, Tedesco MB, Sereika SM, Syed MA, Garcia-Ocaña A, Bisello A, Hollis BW, Rosen CJ, Wysolmerski JJ, Dann P, Gundberg CM, Stewart AF. Continuous infusion of parathyroid hormone versus parathyroid hormone-related protein in humans: discordant effects on 1,25(OH)2 vitamin D and prolonged suppression of bone formation. J Bone Min Res (in revision) 2005.

11. Horwitz MJ, Tedesco MB, Sereika SM, Garcia-Ocaña A, Bisello A, Hollis BW, Gundberg CM, Stewart AF. Safety and Tolerability of Subcutaneous PTHrP(1-36) in Healthy Human Volunteers: A Dose Escalation Study. Osteoporosis International (in revision) 2005.

12. Fiaschi-Taesch N, Sicari B, Bigatel T, Takane KK, Cozar-Castellano I, Law B, Stewart AF. The Cellular Mechanism Through Which PTH-related Protein Induces Proliferation in Arterial Smooth Muscle Cells: Definition of an Arterial Smooth Muscle PTHrP-p27cip Axis. (submitted) 2005.

13. Zgibor JC, Orchard TJ, Saul M, Piatt G, Ruppert K, Stewart AF, Siminerio LM. Developing and validating an administrative diabetes data: implications for diabetes care in a large health system. (Submitted) 2005.

14. Stewart AF, Broadus AE: Malignancy-associated hypercalcemia. In: Endocrinology, Fifth edition. DeGroot L, Jameson LJ (eds.), W.B. Saunders, Philadelphia, (in press) 2005.

b. Abstracts: Six

85



Name: Andrew F. Stewart M.D.Section: Internal Medicine, Endocrinology Type of Activity Date(s) Location/Course



C. Consult Service1. General Medicine2. Subspecialty (Endocrinology) March 2004 PUH/Montefiore/VA

May 2005 PUH/MontefioreD. Student Tutor E. 2nd Year Clinical Tutor Jan-Feb, 2005 Physical Diagnosis Course

F. Others (specify) Research Advisor: Karen Takane PhD, Mara Horwitz MD, Nathlie Fiaschi PhD, Irene Cozar PhD, Kiran Ubrianai MD

II. Lecture/Seminar

A. For Residents Miscellaneous Lectures to Oncology, Orthopedics, Pediatric Endocrinology, Adult Endocrinology, Hoouse Staff Conferences, Cell Biology, Physiology, and Resident’s Conferences. Resident morning report once per month.

B. For Students Endocrinology Second Year Course: 7 lectures, 2 PBLs

C. Others Miscellaneous Lectures to Oncology, Orthopedics, Pediatric Endocrinology, Adult Endocrinology, Pharmacology, GI, Pathology, Pulmonary, Cell Biology, Physiology, and Resident’s Conferences.

III. UPMC Medical Grand Rounds May 13, 2005

IV. Affiliated Hospital Program None.

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2004 - 2005

Name: Nathalie M Fiaschi-Taesch

Title: Instructor of Medicine


Honors: None

Committees: None


a. February 25, 2005. Research Conference Speaker: PTHrP as a Regulator of Arterial Smooth Muscle Proliferation and Angioplasty-Induced Re-Stenosis.” School of Medicine, Strasbourg, France

b. March 30, 2005. Symposium Speaker. “PTHrP as a regulator of arterial smooth muscle proliferation and angioplasty-induced re-stenosis.” AIMM/ASBMR John Haddad Young Investigators’ Meeting, Snowmass, CO.


Research Topics:

a. Vascular actions of parathyroid hormone-related protein and therapy for arterial re-stenosis.b. Physiologic and therapeutic effects of parathyroid hormone-related protein and hepatocyte

growth factor on the pancreatic islet



1. R-33 066127 (Stewart PI) NIH/NIDDK 10/1/03 - 9/30/06 $500,000/yrIslet Allograft Gene Therapy in Diabetes

Pending:

1. RO1 Research Grant (Fiaschi-Taesch PI) NIH 12/1/05 – 11/30/10 $225,000/yrPTHrP as a regulator of vascular cell cycle and neointima formation

87


a. Manuscripts

Published:

1. Taesch N, Takane KK, Masters S, Lopez-Talavera J-C, Stewart, AF. Parathyroid Hormone-related Protein as a Regulator of pRb and the Cell Cycle in Arterial Smooth Muscle. Circulation 110:177-85, 2004.


1. Fiaschi-Taesch N, Sicari B, Bigatel T, Takane KK, Cozar-Castellano I, Law B, Stewart AF. The Cellular Mechanism Through Which PTH-related Protein Induces Proliferation in Arterial Smooth Muscle Cells: Definition of an Arterial Smooth Muscle PTHrP-p27cip Axis. (submitted) 2004.

2. Welsch S, Schordan E, Massfelder T, Fiaschi-Taesch N, Lambert A, Helwig JJ, Barthelmebs M. Is the downregulation of type 1 PTH/PTHrP Receptor a General Feature of the Cardiovascular System in Hypertensive Rats? (Submitted) 2005

b. Abstracts: one

88



Name: Nathalie Fiaschi-TaeschSection: Internal Medicine, Endocrinology Type of Activity Date(s) Location/Course




D. Student Tutor E. 2nd Year Clinical TutorF. Others (specify) Research Advisor: Karen Takane PhD,

Kiran Ubriani MDII. Lecture/Seminar

A. For Residents

B. For Students

C. Others


IV. Affiliated Hospital Program None.

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2004 - 2005

Name: Frederico Granchi Steidel de Toledo, MD

Title: Instructor of Medicine


Committees:

a. National:b. University:c. Hospital: Diabetes Safety Committee (2004)d. Departmental:e. Veterans Hospital:

Research Topics:

a. Type-2 Diabetes Mellitus.b. Human in vivo pathophysiology of insulin resistance and obesityc. Lipid disorders in obesityd. Clinical trial of a new medication (Novartis) for type-2 DM


a. Manuscripts

Published:

1. Toledo FGS, Taylor A. Alternative site testing at the earlobe tip: Reliability of glucose measurements and pain perception. Diabetes Care 27:616-6-617, 2004.

2. De Toledo FG, Symes SN. Leukemoid reaction due to Clostridium dificile infection in acquired immunodeficiency syndrome: Two case reports and a review of the literature. South Med J 97:388-392, 2004.

In Press:

1. Menshikova EV, Ritov VB, Toledo FGS, Ferrell RE, Goodpaster BH, Kelley DE. Effects of Weight Loss and Physical Activity on Skeletal Muscle Mitochondrial Function in Obesity. Am J Physiol Endocrinol Metab: (in press), 2005.

2. Toledo FGS, Kelley DE. Mitochondrial dysfunction in the pathogenesis of insulin resistance associated with obesity, diabetes and aging. Current Opinion in Diabetes and Metabolism (in Press), 2005

90

b. Abstracts: two, submitted to 2005 ADA meeting.

c. Textbook chapters:

In Press:

1. Toledo, FGS. “Glycemic control during enteral and parenteral nutritional support”. In: “Nutrição enteral e parenteral” [Enteral and Parenteral Nutrition]. Chapter 90. Ed. Revinter , 2005 (in press).

2. Andrade, P, Toledo, FGS, and Lameu, E. “Carbohydrates: Biochemical, digestion and absorption” In: “Nutrição enteral e parenteral” [Enteral and Parenteral Nutrition]. Chapter 06, ed. Revinter , 2005 (in press).

3. Lameu, E, and Toledo, FGS. “Water and Electrolytes” In: “Nutrição enteral e parenteral” [Enteral and Parenteral Nutrition]. Chapter 11, ed. Revinter , 2005 (in press).

91



Name: Frederico G. S. Toledo, MDSection: Internal Medicine, Endocrinology Type of Activity Date(s) Location/Course

I. AttendingA. Inpatient General MedicineB. Outpatient C. Consult Service

1. Subspecialty (Endocrinology) January 2005 PUH/MontefioreFebruary 2005 PUH/Montefiore

II. Lecture/Seminar

A. For Residents/Fellows: Adult Endocrinology (Patient Care Conference)

B. For Students Endocrinology Second Year Course: 3 PBLs

C. Others 07/2004-07/2005 Coordinator of the Endocrinology Fellows’ Board Review Club

92

ANNUAL REPORTDivision of Endocrinology

2004-2005

Name: Anthony H. Vagnucci, M.D.

Title: Professor of MedicineProgram Director, Diabetes Consultation and Education Clinic Latrobe Area HospitalSupervisor, Forbes Avenue and Bellefield Towers Ambulatory Primary Medicine

Clinics, Western Psychiatric Institutes and Clinics


Honors: None

Committees:a. National: Noneb. University: Nonec. Hospital: None




Research Topics:

a. Diabetes mellitus - management and treatment (Latrobe)b. Adrenal dysfunctionc. Circadian cycles, cortisold. Correlation antipsychotics with prolactin and sexual dysfunction (WPIC)

Reviewer:Diabetes CareJournal of Endocrinology and Metabolism

93



1. Stanley Foundation (Ganguli) 2003-2006 $35,372A Randomized, Double-blind, Placebo Controlled, Clinical Trial of Adjunctive Treatment with Pravastatin in Partially Remitted Patients with Schizophrenia or Schizoaffective Disorder

2. R01 (Ganguli) NIH 2004-2009 $89,642A Clinical Trial of Weight Reduction in Schizophrenia

Awards: None

Publications:a. Manuscripts

Published:

None

b. Abstracts:

None

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Name: Anthony H. Vagnucci, M.D.Section: Endocrinology_____________________________________________________________________


I. AttendingA. Inpatient General Medicine No rounding assignment

B. Outpatient1. Residents/Fellows Weekly Clinic No trainees assigned

C. Consult Service1. Subspecialty (Endocrinology) No rounding assignment

D. Other (Specify)

II. Lecture/SeminarA. Residents Family Practice Program

Latrobe Area HospitalDiabetes Lecture Series

B. For students

C. Other

III. UPMC Medical Grand RoundsIV. Affiliated Hospital Program Diabetes Lecture Series

Glucose Control in DiabetesLatrobe Area Hospital

New Definition of DiabetesLatrobe Area Hospital

Oral HypoglycemicsLatrobe Area Hospital

Sexual Function in DiabetesLatrobe Area Hospital

Use of Insulin in DiabetesLatrobe Area Hospital

V. Continuing Education (Community)

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2004 - 2005

Name: Rupangi C. Vasavada, Ph.D.

Title: Research Assistant Professor of Medicine


Honors: Invited Speaker at the Pittsburgh PTH-PTHrP Conference, Yale University, CT, July 15-16, 2005.

.Committees:

a. National: None

b. University: None

c. Hospital: None

d. Departmental: Committee for Endocrine Research Conference (2000-2004)


Invited Lectures, Seminars: a. February 13, 2004. Endocrine Research Conference. "Effect of Parathyroid Hormone-Related

Protein on Pancreatic Beta Cell Survival" Yale University, School of Medicine, New Haven, CT.b. November 1, 2004. “Regulation of pancreatic beta cell survival: The role of PTHrP" Magee

Women’s Research Institute, University of Pittsburgh, Pittsburgh, PA.c. March 15, 2005. Endocrine Bone Club Conference. “PTHrP is a Beta Cell Mitogen in Vivo and

in Vitro through PI3K/PKC Activation” Division of Endocrinology, University of Pittsburgh, Pittsburgh, PA.

d. April 21, 2005. Endocrine Research Conference. “Lactogens and the Pancreatic Beta Cell” Division of Endocrinology, University of Pittsburgh, Pittsburgh, PA.

e. July 15-16, 2005. “PTHrP and the Pancreatic Beta Cell” Pittsburgh PTH-PTHrP Conference, Yale University, CT.


Editor – NoneAssociate Editor --NoneEditorial Boards--None

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Research Topics:

a. Physiologic and therapeutic effects of parathyroid hormone-related peptide on the pancreatic beta cell.

b. Physiologic and therapeutic effects of lactogens on the pancreatic beta cell.



1. Junior Faculty Award (Vasavada) ADA 1/1/02-12/31/04 $120,000/yr"Mechanisms of pancreatic beta cell death resistance mediated by parathyroid hormone-related protein".

2. R-21-DK068831-01 (Vasavada) NIH/NIDDK 7/15/04-6/30/06 $150,000/yr“Parathyroid hormone-related protein in the human islet".

Pending:

1. R-01- No Number (Vasavada) NIH/NIDDK 7/1/05-6/30/10 $175,000/yr“Lactogens and Pancreatic Beta Cell Survival”.Scored: 161; Percentile: 16.8

2. Career Development Award (Vasavada) ADA 7/1/05-6/30/10 $172,500/yr“Lactogens and Pancreatic Beta Cell Survival”.

3. Career Development Award (Vasavada) JDRF 7/1/05-6/30/10 $125,000/yr“Lactogens and Pancreatic Beta Cell Survival”.


a. Manuscripts

Published:

1. Rao P, Cozar-Castellano I, Roccisana J, Vasavada RC, Garcia-Ocaña A. Hepatocyte growth factor gene therapy for islet transplantation. Expert Opin Biol Ther 4:507-518 (2004).

2. Fujinaka Y, Sipula D, Garcia-Ocaña A, Vasavada RC. Characterization of mice doubly transgenic for parathyroid hormone-related protein and murine placental lactogen: a novel role for placental lactogen in pancreatic beta cell survival. Diabetes 53:3120-3130 (2004).


1. Roccisana J, Reddy V, Vasavada RC, Gonzalez-Pertusa JA, Magnuson MA, Garcia-Ocaña A. Targeted inactivation of HGF receptor, c-met, in beta cells leads to defective insulin secretion and Glut-2 downregulation without alteration of beta cell mass. Diabetes, in revision, 2005.

b. Abstracts: Three

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Name: Rupangi C. Vasavada Ph.D.Section: Internal Medicine, Endocrinology Type of Activity Date(s) Location/Course

I. Attending NoneA. Inpatient General MedicineB. Outpatient



D. Student Tutor E. 2nd Year Clinical TutorF. Others (specify) Research Advisor: Yuichi Fujinaka MD, Ph.D.

II. Lecture/Seminar

A. For Residents Lecture to Pediatric Endocrinology, Adult Endocrinology, on 7/04 on"Introduction to core research techniques".

B. For Students Graduate Student Course. "Molecular Mechanisms of Tissue growth and differentiation" One lecture each 2/04 and 2/05.

C. Others None.



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Annual Report 2005.doc

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Transcript of Annual Report 2005.doc