Anemia in Scurvy - SpringerANEMIA IN SCURVY A 60-year-old man from rural Oregon was admitted with...
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CLINICAL PRACTICE Clinical Images Anemia in Scurvy Jeffrey Y. Bien, MD 1 , Richie Hegarty, MD 1 , and Brian Chan, MD, MPH 2 1 Department of Medicine , Oregon Health & Science University, Portland, OR, USA; 2 Division of General Internal Medicine & Geriatrics, Oregon Health & Science University, Portland, OR, USA. KEY WORDS: scurvy; anemia; disparity; deficiency. J Gen Intern Med 33(11):2008–9 DOI: 10.1007/s11606-018-4597-1 © Society of General Internal Medicine 2018 ANEMIA IN SCURVY A 60-year-old man from rural Oregon was admitted with symptomatic anemia, progressive, bilateral, dependent-leg ec- chymoses (Fig. 1), and knee arthropathy. Physical exam re- vealed Bcorkscrew hairs,^ most distinctively on his shoulder (Fig. 2). A social history was notable for limited financial resources and a longstanding diet consisting solely of toast, boxed macaroni and cheese, and canned tuna. Following administration of vitamin C, the patient’ s hemat- ocrit stabilized. The serum vitamin C level from admission returned undetectable, confirming a diagnosis of scurvy. Upon discharge, he received dietary counseling and a multivitamin prescription. Scurvy is caused by dietary deficiency of vitamin C, a key cofactor for collagen enzymes. It is the only known acquired connective-tissue disorder that is not immune-mediated. Ane- mia in scurvy can result from vascular fragility and subsequent subcutaneous hemorrhage and hemarthrosis. 1 Other features include gingivitis, myalgias, mood changes, perifollicular hemorrhage, occult gastrointestinal hemorrhage, and delayed wound healing. First described in 1753, scurvy is now rarely diagnosed in developed countries. 2 However, even in devel- oped countries, associations between scurvy and low-income status persist. 3, 4 As in our case, the acute presentation of scurvy can mimic an acquired coagulopathy. A careful history and physical exam may preclude a costly workup and expedite treatment. Corresponding Author: Jeffrey Y. Bien, MD; Department of Medicine Oregon Health & Science University, Portland, OR, USA (e-mail: [email protected]). Figure 1 Painful, dependent ecchymoses and arthropathy of bilateral lower extremities from hemorrhage tracking along fascial planes. Figure 2 Patient’ s body hair (shown: right shoulder) growing in a distinctive Bcorkscrew^ or Bkinked^ pattern. Received March 9, 2018 Revised May 22, 2018 Accepted July 13, 2018 Published online July 27, 2018 2008 JGIM
Transcript of Anemia in Scurvy - SpringerANEMIA IN SCURVY A 60-year-old man from rural Oregon was admitted with...
CLINICAL PRACTICEClinical ImagesAnemia in ScurvyJeffrey Y. Bien, MD1, Richie Hegarty, MD1, and Brian Chan, MD, MPH2
1Department of Medicine , Oregon Health & Science University, Portland, OR, USA; 2Division of General Internal Medicine & Geriatrics, OregonHealth & Science University, Portland, OR, USA.
KEY WORDS: scurvy; anemia; disparity; deficiency.
J Gen Intern Med 33(11):2008–9
DOI: 10.1007/s11606-018-4597-1
© Society of General Internal Medicine 2018
ANEMIA IN SCURVY
A 60-year-old man from rural Oregon was admitted withsymptomatic anemia, progressive, bilateral, dependent-leg ec-chymoses (Fig. 1), and knee arthropathy. Physical exam re-vealed Bcorkscrew hairs,^ most distinctively on his shoulder(Fig. 2). A social history was notable for limited financialresources and a longstanding diet consisting solely of toast,boxed macaroni and cheese, and canned tuna.Following administration of vitamin C, the patient’s hemat-
ocrit stabilized. The serum vitamin C level from admissionreturned undetectable, confirming a diagnosis of scurvy. Upondischarge, he received dietary counseling and a multivitaminprescription.Scurvy is caused by dietary deficiency of vitamin C, a key
cofactor for collagen enzymes. It is the only known acquiredconnective-tissue disorder that is not immune-mediated. Ane-
mia in scurvy can result from vascular fragility and subsequentsubcutaneous hemorrhage and hemarthrosis.1 Other featuresinclude gingivitis, myalgias, mood changes, perifollicularhemorrhage, occult gastrointestinal hemorrhage, and delayedwound healing. First described in 1753, scurvy is now rarelydiagnosed in developed countries.2 However, even in devel-oped countries, associations between scurvy and low-incomestatus persist.3, 4 As in our case, the acute presentation ofscurvy can mimic an acquired coagulopathy. A careful historyand physical exammay preclude a costly workup and expeditetreatment.
Corresponding Author: Jeffrey Y. Bien, MD; Department of MedicineOregon Health & Science University, Portland, OR, USA(e-mail: [email protected]).
Figure 1 Painful, dependent ecchymoses and arthropathy of bilaterallower extremities from hemorrhage tracking along fascial planes.
Figure 2 Patient’s body hair (shown: right shoulder) growing in adistinctive Bcorkscrew^ or Bkinked^ pattern.
Received March 9, 2018Revised May 22, 2018Accepted July 13, 2018Published online July 27, 2018
2008
JGIM
Compliance with Ethical Standards:
Conflict of Interest: The authors declare that they do not have aconflict of interest.
Disclaimers: None.
REFERENCES1. Reuler, J. B., Broudy, V. C. & Cooney, T. G. Adult Scurvy. JAMA 253,
805–807 (1985).
2. Lind, J. A treatise on the scurvy : in three parts, containing an inquiry intothe nature, causes, and cure, of that disease : together with a critical andchronological view of what has been published on the subject. (London,1753).
3. Schleicher, R. L., Carroll, M. D., Ford, E. S. & Lacher, D. A. Serumvitamin C and the prevalence of vitamin C deficiency in the United States:2003-2004 National Health and Nutrition Examination Survey (NHANES).Am. J. Clin. Nutr. 90, 1252–1263 (2009).
4. Mosdøl, A., Erens, B. & Brunner, E. J. Estimated prevalence andpredictors of vitamin C deficiency within UK’s low-income population.J. Public Health Oxf. Engl. 30, 456–460 (2008).
2009Bien et al.: Anemia in ScurvyJGIM
