ANAT2341 Lecture 7 - Beverdam - Mesoderm Development · No screen snap shots or copying of quiz...
Transcript of ANAT2341 Lecture 7 - Beverdam - Mesoderm Development · No screen snap shots or copying of quiz...
![Page 1: ANAT2341 Lecture 7 - Beverdam - Mesoderm Development · No screen snap shots or copying of quiz questions ... Dermatome Development Embryonic dermatomes will form the ... ANAT2341](https://reader034.fdocuments.net/reader034/viewer/2022042801/5af105497f8b9a572b9037d2/html5/thumbnails/1.jpg)
![Page 2: ANAT2341 Lecture 7 - Beverdam - Mesoderm Development · No screen snap shots or copying of quiz questions ... Dermatome Development Embryonic dermatomes will form the ... ANAT2341](https://reader034.fdocuments.net/reader034/viewer/2022042801/5af105497f8b9a572b9037d2/html5/thumbnails/2.jpg)
Quizrules:
SpreadoutacrossavailabletablesNophones,textbooks,or(lecture)notesonyourdesks
NoconsultationwithyourcolleaguesNowebsitesopenotherthantheQuizpage
NoscreensnapshotsorcopyingofquizquestionsPenaltieswillapply
![Page 3: ANAT2341 Lecture 7 - Beverdam - Mesoderm Development · No screen snap shots or copying of quiz questions ... Dermatome Development Embryonic dermatomes will form the ... ANAT2341](https://reader034.fdocuments.net/reader034/viewer/2022042801/5af105497f8b9a572b9037d2/html5/thumbnails/3.jpg)
Mesoderm Development
DrAnnemiekBeverdam– SchoolofMedicalSciences,UNSWWallaceWurth BuildingRoom234– [email protected]
Resources:http://php.med.unsw.edu.au/embryology/
Larsen’s Human EmbryologyThe Developing Human: Clinically Oriented Embryology
![Page 4: ANAT2341 Lecture 7 - Beverdam - Mesoderm Development · No screen snap shots or copying of quiz questions ... Dermatome Development Embryonic dermatomes will form the ... ANAT2341](https://reader034.fdocuments.net/reader034/viewer/2022042801/5af105497f8b9a572b9037d2/html5/thumbnails/4.jpg)
Week 3 Lecture overview
DrAnnemiekBeverdam– SchoolofMedicalSciences,UNSWWallaceWurth BuildingRoom234– [email protected]
Gastrulation
Early Mesoderm Development
Notochord
Paraxial Mesoderm
Intermediate Mesoderm
Lateral Plate Mesoderm
![Page 5: ANAT2341 Lecture 7 - Beverdam - Mesoderm Development · No screen snap shots or copying of quiz questions ... Dermatome Development Embryonic dermatomes will form the ... ANAT2341](https://reader034.fdocuments.net/reader034/viewer/2022042801/5af105497f8b9a572b9037d2/html5/thumbnails/5.jpg)
GastrulationWeek 3
Ingression of epiblast cells: EMT transitionGeneration of definitive endoderm
Generation of intra-embryonic mesodermOropharyngeal and cloacal membrane
Embryonic ectoderm
http://php.med.unsw.edu.au/embryology/images/5/55/Mesoderm_001.mp4
![Page 6: ANAT2341 Lecture 7 - Beverdam - Mesoderm Development · No screen snap shots or copying of quiz questions ... Dermatome Development Embryonic dermatomes will form the ... ANAT2341](https://reader034.fdocuments.net/reader034/viewer/2022042801/5af105497f8b9a572b9037d2/html5/thumbnails/6.jpg)
End product gastrulation:Trilaminar embryo
Ectoderm (Neural crest)brain, spinal cord, eyes, peripheral nervous system
epidermis of skin and associated structures, melanocytes, cranial connective tissues (dermis)
Mesodermmusculo-skeletal system
limbsconnective tissue of skin and organsurogenital system, heart, blood cells
Endodermepithelial linings of gastrointestinal and respiratory tracts
![Page 7: ANAT2341 Lecture 7 - Beverdam - Mesoderm Development · No screen snap shots or copying of quiz questions ... Dermatome Development Embryonic dermatomes will form the ... ANAT2341](https://reader034.fdocuments.net/reader034/viewer/2022042801/5af105497f8b9a572b9037d2/html5/thumbnails/7.jpg)
Page342S.F.GilbertDevelopmentalBiology5thedition
Embryonic development:
![Page 8: ANAT2341 Lecture 7 - Beverdam - Mesoderm Development · No screen snap shots or copying of quiz questions ... Dermatome Development Embryonic dermatomes will form the ... ANAT2341](https://reader034.fdocuments.net/reader034/viewer/2022042801/5af105497f8b9a572b9037d2/html5/thumbnails/8.jpg)
EarlyMesodermDevelopment
![Page 9: ANAT2341 Lecture 7 - Beverdam - Mesoderm Development · No screen snap shots or copying of quiz questions ... Dermatome Development Embryonic dermatomes will form the ... ANAT2341](https://reader034.fdocuments.net/reader034/viewer/2022042801/5af105497f8b9a572b9037d2/html5/thumbnails/9.jpg)
EarlyMesodermDevelopment
1 23 4
NeuralTube
1:notochord2:paraxialmesoderm3:intermediatemesoderm4:lateralplatemesoderm
![Page 10: ANAT2341 Lecture 7 - Beverdam - Mesoderm Development · No screen snap shots or copying of quiz questions ... Dermatome Development Embryonic dermatomes will form the ... ANAT2341](https://reader034.fdocuments.net/reader034/viewer/2022042801/5af105497f8b9a572b9037d2/html5/thumbnails/10.jpg)
EarlyMesodermDevelopment
1 23 4
NeuralTube
1:notochord2:paraxialmesoderm3:intermediatemesoderm4:lateralplatemesoderm
![Page 11: ANAT2341 Lecture 7 - Beverdam - Mesoderm Development · No screen snap shots or copying of quiz questions ... Dermatome Development Embryonic dermatomes will form the ... ANAT2341](https://reader034.fdocuments.net/reader034/viewer/2022042801/5af105497f8b9a572b9037d2/html5/thumbnails/11.jpg)
1:Notochord
AxialmesodermTransient
DevelopmentNeurenteric canal
Crucialsignalling centreMechanicalroleinembryonicfolding
Notochordal plate
Hollow
Solid
![Page 12: ANAT2341 Lecture 7 - Beverdam - Mesoderm Development · No screen snap shots or copying of quiz questions ... Dermatome Development Embryonic dermatomes will form the ... ANAT2341](https://reader034.fdocuments.net/reader034/viewer/2022042801/5af105497f8b9a572b9037d2/html5/thumbnails/12.jpg)
1:Notochord
![Page 13: ANAT2341 Lecture 7 - Beverdam - Mesoderm Development · No screen snap shots or copying of quiz questions ... Dermatome Development Embryonic dermatomes will form the ... ANAT2341](https://reader034.fdocuments.net/reader034/viewer/2022042801/5af105497f8b9a572b9037d2/html5/thumbnails/13.jpg)
EarlyMesodermDevelopment
1 23 4
NeuralTube
1:notochord2:paraxialmesoderm3:intermediatemesoderm4:lateralplatemesoderm
![Page 14: ANAT2341 Lecture 7 - Beverdam - Mesoderm Development · No screen snap shots or copying of quiz questions ... Dermatome Development Embryonic dermatomes will form the ... ANAT2341](https://reader034.fdocuments.net/reader034/viewer/2022042801/5af105497f8b9a572b9037d2/html5/thumbnails/14.jpg)
2:ParaxialMesoderm
Cranial:Unsegmentedparaxialmesoderm:headmesenchyme
Trunk:Segmentedparaxialmesoderm:somites
![Page 15: ANAT2341 Lecture 7 - Beverdam - Mesoderm Development · No screen snap shots or copying of quiz questions ... Dermatome Development Embryonic dermatomes will form the ... ANAT2341](https://reader034.fdocuments.net/reader034/viewer/2022042801/5af105497f8b9a572b9037d2/html5/thumbnails/15.jpg)
2:ParaxialMesodermSomitogenesis
Block-likebilateralcondensationsoftheparaxialmesodermFormevery90minuts inacranialtocaudaldirection(day20today30)
‘Segmentationclock’dependsonHes7 transcription/translation44maxareformed,33remain
Giverisetoaxialskeletonandmusculature,dermisofthetrunk
![Page 16: ANAT2341 Lecture 7 - Beverdam - Mesoderm Development · No screen snap shots or copying of quiz questions ... Dermatome Development Embryonic dermatomes will form the ... ANAT2341](https://reader034.fdocuments.net/reader034/viewer/2022042801/5af105497f8b9a572b9037d2/html5/thumbnails/16.jpg)
2:ParaxialMesodermSomiteDevelopment
Somites developinto:- Sclerotome:mesenchymalcells(vertebralbodyandintervertebraldisk)- Dermomyotome:columnarepithelium
Dermomyotome developsinto:- Dermatome:dermisofthetrunk- Myotome:trunkmusculature
![Page 17: ANAT2341 Lecture 7 - Beverdam - Mesoderm Development · No screen snap shots or copying of quiz questions ... Dermatome Development Embryonic dermatomes will form the ... ANAT2341](https://reader034.fdocuments.net/reader034/viewer/2022042801/5af105497f8b9a572b9037d2/html5/thumbnails/17.jpg)
2:ParaxialMesodermSomiteDevelopment
Sonichedgehog(Shh)(notochordandfloorplate):ventralsomites.BMP-4:lateralsomites.Wnt familyproteins(roofplate):dorsalsomites.
![Page 18: ANAT2341 Lecture 7 - Beverdam - Mesoderm Development · No screen snap shots or copying of quiz questions ... Dermatome Development Embryonic dermatomes will form the ... ANAT2341](https://reader034.fdocuments.net/reader034/viewer/2022042801/5af105497f8b9a572b9037d2/html5/thumbnails/18.jpg)
2:ParaxialMesodermSomiteDerivativeSpecificationdependsonAPlevel/Hox code
7:cervicalregion
12:thoracicregion
5:lumbarregion
5:sacralregion
4:caudalregion(tail)
![Page 19: ANAT2341 Lecture 7 - Beverdam - Mesoderm Development · No screen snap shots or copying of quiz questions ... Dermatome Development Embryonic dermatomes will form the ... ANAT2341](https://reader034.fdocuments.net/reader034/viewer/2022042801/5af105497f8b9a572b9037d2/html5/thumbnails/19.jpg)
2:ParaxialMesodermSomiteDevelopment
![Page 20: ANAT2341 Lecture 7 - Beverdam - Mesoderm Development · No screen snap shots or copying of quiz questions ... Dermatome Development Embryonic dermatomes will form the ... ANAT2341](https://reader034.fdocuments.net/reader034/viewer/2022042801/5af105497f8b9a572b9037d2/html5/thumbnails/20.jpg)
2:ParaxialMesodermMyotomeDevelopment
Epaxial myotome:epimere:erectorspinaeHypoaxial myotome:hypomere:3primarymusclelayers
MyoD initiatesmyogenesis
![Page 21: ANAT2341 Lecture 7 - Beverdam - Mesoderm Development · No screen snap shots or copying of quiz questions ... Dermatome Development Embryonic dermatomes will form the ... ANAT2341](https://reader034.fdocuments.net/reader034/viewer/2022042801/5af105497f8b9a572b9037d2/html5/thumbnails/21.jpg)
2:ParaxialMesodermMyotomeDevelopment
![Page 22: ANAT2341 Lecture 7 - Beverdam - Mesoderm Development · No screen snap shots or copying of quiz questions ... Dermatome Development Embryonic dermatomes will form the ... ANAT2341](https://reader034.fdocuments.net/reader034/viewer/2022042801/5af105497f8b9a572b9037d2/html5/thumbnails/22.jpg)
2:ParaxialMesodermDermatomeDevelopment
EmbryonicdermatomeswillformthedermisPostnataldermatomeisastripofskininnervatedbyasinglespinalnerve
![Page 23: ANAT2341 Lecture 7 - Beverdam - Mesoderm Development · No screen snap shots or copying of quiz questions ... Dermatome Development Embryonic dermatomes will form the ... ANAT2341](https://reader034.fdocuments.net/reader034/viewer/2022042801/5af105497f8b9a572b9037d2/html5/thumbnails/23.jpg)
EarlyMesodermDevelopment
1 23 4
NeuralTube
1:notochord2:paraxialmesoderm3:intermediatemesoderm4:lateralplatemesoderm
![Page 24: ANAT2341 Lecture 7 - Beverdam - Mesoderm Development · No screen snap shots or copying of quiz questions ... Dermatome Development Embryonic dermatomes will form the ... ANAT2341](https://reader034.fdocuments.net/reader034/viewer/2022042801/5af105497f8b9a572b9037d2/html5/thumbnails/24.jpg)
3:IntermediateMesodermSegmentedandunsegmentedintermediatemesoderm
MesonephricductUrogenitalsinus
MesonephrictubulesUretericbuds
![Page 25: ANAT2341 Lecture 7 - Beverdam - Mesoderm Development · No screen snap shots or copying of quiz questions ... Dermatome Development Embryonic dermatomes will form the ... ANAT2341](https://reader034.fdocuments.net/reader034/viewer/2022042801/5af105497f8b9a572b9037d2/html5/thumbnails/25.jpg)
3:IntermediateMesoderm3nephricsystems:- Pronephros:regress- Mesonephros:reproductivesystem,andcollectingductandtubulesofthekidney- Metanephros:nephronsofthekidney
![Page 26: ANAT2341 Lecture 7 - Beverdam - Mesoderm Development · No screen snap shots or copying of quiz questions ... Dermatome Development Embryonic dermatomes will form the ... ANAT2341](https://reader034.fdocuments.net/reader034/viewer/2022042801/5af105497f8b9a572b9037d2/html5/thumbnails/26.jpg)
EarlyMesodermDevelopment
1 23 4
NeuralTube
1:notochord2:paraxialmesoderm3:intermediatemesoderm4:lateralplatemesoderm
![Page 27: ANAT2341 Lecture 7 - Beverdam - Mesoderm Development · No screen snap shots or copying of quiz questions ... Dermatome Development Embryonic dermatomes will form the ... ANAT2341](https://reader034.fdocuments.net/reader034/viewer/2022042801/5af105497f8b9a572b9037d2/html5/thumbnails/27.jpg)
4:LateralPlateMesoderm
Lateralplatemesodermdevelopsinto:- Splanchnic/visceralmesoderm- Somatic/parietalmesoderm
Intraembryoniccoelom:3cavities:- Pericard- Pleural- Peritoneal
![Page 28: ANAT2341 Lecture 7 - Beverdam - Mesoderm Development · No screen snap shots or copying of quiz questions ... Dermatome Development Embryonic dermatomes will form the ... ANAT2341](https://reader034.fdocuments.net/reader034/viewer/2022042801/5af105497f8b9a572b9037d2/html5/thumbnails/28.jpg)
Somatic/parietalmesoderm:somatopleure- Closesttoectoderm- Givesriseto:
• Connectivetissueandliningofthebodywall• Bones,ligamentsanddermisofthelimbs
Splanchnic/visceralmesoderm:splanchnopleure- Closesttoendoderm- Givesriseto:
• Cardiacmesoderm(prechordal splanchnicmesoderm)• Bloodvessels• Smoothmusclesofthegut
4:LateralPlateMesoderm
![Page 29: ANAT2341 Lecture 7 - Beverdam - Mesoderm Development · No screen snap shots or copying of quiz questions ... Dermatome Development Embryonic dermatomes will form the ... ANAT2341](https://reader034.fdocuments.net/reader034/viewer/2022042801/5af105497f8b9a572b9037d2/html5/thumbnails/29.jpg)
Page342S.F.GilbertDevelopmentalBiology5thedition
Embryonic development:
![Page 30: ANAT2341 Lecture 7 - Beverdam - Mesoderm Development · No screen snap shots or copying of quiz questions ... Dermatome Development Embryonic dermatomes will form the ... ANAT2341](https://reader034.fdocuments.net/reader034/viewer/2022042801/5af105497f8b9a572b9037d2/html5/thumbnails/30.jpg)
Week 3 Lecture overview
DrAnnemiekBeverdam– SchoolofMedicalSciences,UNSWWallaceWurth BuildingRoom234– [email protected]
Placentation
Body axes
Gastrulation
Axis formation
Embryo folding
Lecture contents relevant to Labs 3 and 7
Resources:http://php.med.unsw.edu.au/embryology/
Larsen’s Human EmbryologyThe Developing Human: Clinically Oriented Embryology
![Page 31: ANAT2341 Lecture 7 - Beverdam - Mesoderm Development · No screen snap shots or copying of quiz questions ... Dermatome Development Embryonic dermatomes will form the ... ANAT2341](https://reader034.fdocuments.net/reader034/viewer/2022042801/5af105497f8b9a572b9037d2/html5/thumbnails/31.jpg)