The American Journal of Clinical Nutrition American Journal of Clinical Nutrition Skip to main page content Langsung ke konten halaman utama HOME HOME CURRENT ISSUE LANCAR MASALAH EMAIL ALERTS EMAIL TANDA ARCHIVES ARSIP SUBSCRIPTIONS LANGGANAN SEARCH FOR ARTICLES PENCARIAN ARTIKEL Top of FormSearch AJCN Cari AJCN Submit Menyerahkan Advanced Search Advanced Search Bottom of FormTop of FormUser Name Nama User Password Password Sign In Sign In Bottom of Form Expand+American Journal of Clinical Nutrition, Vol. American Journal of Clinical Nutrition, Vol. 71, No. 5, 1295S-1303s, May 2000 71, No 5, 1295S-1303s, Mei 2000 2000 American Society for Clinical Nutrition 2000 American Society Gizi Klinis Supplements Suplemen

Folic acid: influence on the outcome of pregnancy 1 Asam folat: berpengaruh pada hasil kehamilan 1 , 2 , 2 , 3 , 3 , 4 , 4 Theresa O Scholl and William G Johnson Theresa O Scholl dan William G Johnson 1 From the Department of Obstetrics and Gynecology, University of Medicine and Dentistry of New JerseySchool of Osteopathic Medicine, Stratford, and the Department of Neurology, University of Medicine and Dentistry of New JerseyRobert Wood Johnson Medical School, Piscataway. 1 Dari Departemen Obstetri dan Ginekologi, Universitas Kedokteran dan Kedokteran Gigi Sekolah New Jersey-Kedokteran Osteopathic, Stratford, dan Departemen Neurologi, Universitas Kedokteran dan Kedokteran Gigi Robert Wood Johnson Medical School-New Jersey, Piscataway. 2 Presented at the symposium Maternal Nutrition: New Developments and Implications, held in Paris, June 1112, 1998. 2 Disampaikan pada simposium Nutrisi Ibu: Baru Perkembangan dan Implikasi, diadakan di Paris, Juni 11-12, 1998. 3 Supported by grants HD 18269 and ES7437 from the National Institutes of Health. Kesehatan 3 Didukung oleh hibah HD 18269 dan ES7437 dari National Institutes of. 4 Address reprint requests to TO Scholl, UMDNJ-SOM, Department of Obstetrics and Gynecology, Science Center, Suite 185, Stratford, NJ 08084. 4 permintaan cetak ulang Alamat ke TO Scholl, UMDNJ-SOM, Departemen Obstetri dan Ginekologi, Science Center, Suite 185, Stratford, NJ 08084. E-mail: scholl@umdnj.edu . E-mail: disekolah @ umdnj.edu. ABSTRACT ABSTRAK The periconceptional use of folic acid containing supplements reduces the first occurrence, as well as the recurrence, of neural tube defects. Penggunaan periconceptional dari asam folat yang mengandung suplemen mengurangi kejadian pertama, serta kambuh, cacat tabung saraf. Women of populations in which adverse pregnancy outcomes are prevalent often consume diets that contain a low density of vitamins and minerals, including folate. Perempuan populasi di mana merugikan kehamilan yang lazim sering mengkonsumsi makanan yang mengandung kepadatan rendah vitamin dan mineral, termasuk folat. Folate intake may need to be sustained after complete closure of the neural tube to decrease the risk of other poor pregnancy outcomes. Asupan Folat mungkin perlu dipertahankan setelah penutupan lengkap dari tabung saraf untuk mengurangi risiko lainnya hasil kehamilan yang buruk. A central feature of embryonic and fetal development is widespread cell division; folate is central because of its role in nucleic acid synthesis. Fitur utama dari perkembangan embrio dan janin adalah pembelahan sel luas; folat adalah pusat karena perannya dalam sintesis asam nukleat. During gestation, marginal folate nutriture can impair cellular growth and replication in the fetus or placenta. Selama kehamilan, folat nutriture marjinal dapat merusak pertumbuhan sel dan replikasi pada janin atau plasenta. Folate deficiency can occur because dietary folate intake is low or because the metabolic requirement for folate is increased by a particular genetic defect or defects. During pregnancy, low concentrations of dietary and circulating folate are associated with increased risks of preterm delivery, infant low birth weight, and fetal growth retardation. kekurangan Folat dapat terjadi karena asupan makanan folat rendah atau karena kebutuhan metabolik untuk folat adalah meningkat cacat genetik tertentu atau cacat berat. Selama kehamilan rendah, konsentrasi makanan dan mengedarkan folat berhubungan meningkat dengan risiko prematur pengiriman lahir bayi rendah, , dan retardasi pertumbuhan janin. A metabolic effect of folate deficiency is an elevation of blood homocysteine. Likewise, the presence of maternal homocysteine concentrations have been associated both with increased habitual spontaneous abortion and pregnancy complications (eg, placental abruption and preeclampsia), which increase the risk of poor pregnancy outcome and of decreased birth weight and gestation duration. Efek metabolik dari kekurangan folat adalah ketinggian homocysteine darah,. Demikian juga kehadiran konsentrasi homosistein ibu telah dikaitkan baik dengan peningkatan aborsi spontan kebiasaan dan komplikasi kehamilan (misalnya plasenta dan preeclampsia), yang meningkatkan risiko hasil kehamilan yang buruk dan penurunan berat lahir dan durasi kehamilan. Key Words: Pregnancy folic acid supplements vitamins homocysteine birth weight preterm delivery spontaneous abortion pregnancy-induced hypertension placental abruption Kata Kunci: Kehamilan folat suplemen vitamin asam berat badan lahir homosistein kelahiran prematur kehamilan spontan aborsi -induced hipertensi plasenta INTRODUCTION PENDAHULUAN An adverse gestational event, such as a conception culminating in spontaneous abortion or stillbirth, is an unwelcome, but not an unusual, pregnancy outcome. Sebuah acara yang merugikan kehamilan, seperti konsepsi mencapai puncaknya pada aborsi spontan atau kelahiran mati, adalah tidak diterima, tapi bukan biasa, hasil kehamilan. Poor outcomes can also occur in pregnancies that give rise to live-born infants and include preterm delivery (