Volume 12, Number 5 November 1988

American Heart AssociationHYPERTENSION

VOL..12 NO. 5 01N0V88

73-2052

88340O4

Hardhearted

Thiazide diuretics

In study after study, they have beenassociated with increases in cholesterol.1

And now, the Lipid Research Clinics Trialhas established a clear link between lipidsand risk of coronary heart disease.2

Thiazide diuretics are also known to causepotassium depletion, which untreated canlead to cardiac disturbance.*

'Because a few patients may be sensitive to the diuretic effects of Lozol,periodic determination of serum electrolytes should be oerformed.

Kindhearted

LOZOL (indapamide)

Clinical data show no significant increasein cholesterol; in a long-term study, choles-terol levels actually fellto below baseline.3

Lozol also has minimal impact on potassium,with 95% of patients showing no clinicalhypokalemia in a long-term trial.4*

That's kindhearted antihypertensive therapy.

ONE A DAY

INDARAMIDEThe diuretic that doesn'tcompromise cholesterol

See following page for brief summary of prescribing information

ONE A CAY

NDAFAM/DE'Z5mg

The diuretic thatdoesn't compromisecholesterolUUOL*

S O ? SUMMARY

I H ) C / n U M «W) U U G t LOZtn. b M a t B l I n tt» D n m e a 01 tirpgnsi-mn. * n e a bi cait*i«)CTnrtJi a t o mt inuct i raw drupLOZOL S l lw Indtttd tor thetnatment ol i l l ind U d retantmt a o a a MvriOi congtstto houttlbre

( » PRECAUTIONS)Anurta, hyperstnsiljvily B moaparnide or odvr surfpiv

urtde-deriwd drug*.

WARKNBS. Hypotatenu occurs commonly wtth dhuebcs, and eltctrofylemoortDrhg Is essential In general. dkiiBUu should not be flhwi concorrJ-Qotty wtUi UHum.

PRECAUTOtt GENERAL 1 Hypo&orm and Other FW nl ElKtnty*UntoMncss Periodic dc>pi i*J*K*a 01 u r u m electrolytes thouidbc pa-fcxraed at ipproprfali intervals In addition, patients thouk) be o b w t d iwdtracal signs or fluid or efcictn*ytt Irnbaiancfl, such as hyponatremla. hypo-crttKBrrtc aflotosa. or hypokatanii Btdroryte dttarmrafcro i n partlcu-Ljrty Important in patients who i n vomiting excessively or r twMrt f l

parentersi b i d s . In patients subjtct to etoctrolytfl Imbalance (VeJudhQ thosewtth heart ta lon . Hdnty dtstau. ind drrtnsa) , and tn patients on • ufc-restricted tflet Tht risk oJ hypofciJimti secondary to dtojrwis md lULkrestst) bxrtasod wton lafQcr doses n ustd, when ttw diuresis b brisk, wtwisovon citrhosls is pftsent md dumg conconitail u n ol corbcDStBroidJ orACTH trttrterinCT wW *d«pia» oril rtate ol e*ectn^yiM w i i b o o w ( r ^ute to hypokaJemia. Hypototemia can «rtstte« w m w w i t f l the resporwoithe heart to t in toxic efiecOol dentals, such i s Increased vartricutif trrttaU-tty DtuboraJ ti^ionatrema may occur In •dcmttom pttentt; Bit •ppro-pflitt trMtmema r tstriction o4 water ntner than adminotntlon d salt,except In ram Instances when the hypooatramii is Ha tvesktt-^ However,In actual sett depletion, ippropnate replacement ts the treatment at choiceAny cWcrttt deficit that may occu; during trmmedisganeiitymidand \t Qeneraly mUd andunUvsrorrtnaJdlsauc2HypenMkamamGoutSerumusmly d o e s n o t r e q u f r t t p e c i f l c i i w U m i t e x c e p t I n s x t r a o n t n a f y c i r c u m -stancts u n Uvsr or rtnaJ dlsauc 2 Hyperurioma and Gout Scrumconcentrations of uric add knenued by an avenge or 1 0 mo/100 ml InptU(ntj t inted with indapunWe, and frank gout may be piocrpriitnj Incartain pabena recervlnc ndapamde (see ADVERSE REACTTOMS) Seromconcemratlom of i n acU snoid t h e n j f o r t b t m o r r t ^treatment 3 Rtnt Imfukmetx Htnal tundion tests trtoirtd be ptrformedperiodically during treatment wtth tndapamide 4 frnpandHepSK FunctionIndapamUe liathtthtazides, stwuW bt iaed wdh caution ri patiena wtfiimpakid hepatic function or processrve h w disease, sinca minor aSera-tons of DUd and etactrotyfe balance may prodpnate hepatic coma 5 GJu-cost Toknna Latent (tabetes may become manifest and hsiiin nqi i r t -ments In diabetic patiants rmy bt artsrsd during thlazidi admrtstrationSerum concentrations or Qtxose stwuU bt montofBd routinely during trojl-rrierilwtthin(taparnide_6 CakMjmExmtnn^Ctkkmsai^atkcnamiby dkLTtdo pharmacotogicaly related to tndaparnidt Indapamidt may dt-crease senjm PK levels wtthoul signs ol tnyroid disturtanca 7 InfractionWth Sytmnic Upta Etythemttma ThowJa havt exactrbated or acb-vrtd tystemic lupus erythemaSMus

DRUG bVTCRACTtONS 1 Ottw ArttypertBrwm LOZOL (Indaptrndt)miy add to or poterrtliU tht tctlon <A othtf inrJhypirtensrvt drugi2 Uttiium S« WARNINGS 3 Post-SympHtmtomy Pttbi The antiny-pertacttht iflacl ol the drug may bt enhanced In the pottfpnpalhectomizad******* * Nixa^ne^rn! tndapamictt may deensse antrial rtsponsiv*-ntss to noreptnepnrint. but this diminution is not sufGoiant to preduditSt&ma ol the pnsne U M t » Itmpeulk u » CARCWOGEWSS.MUTAgMtSlS. WPAlHHaftOf FERTILITY B O O I r r o » W a l l m »cudnoogictty studitt wtrt conducted Them was no stgnUuiU difTtrtnctIn tht Incidence c4 tumors befrntn the iralapamtde-ueited animjts and thtcortrol groupsPft£GNAHCY/TERATOG£HIC EFFECTS PREGNANCY CATEGORY B D4-ureoo are known to cross the pttcantaJ barriar md appear jn cord Moodbtcw%6tcarmt reproduction stuoits art not aAnays predctiw of humanrtsoonst. this drug should bt usod during pregnancy only H ctearty neededNURSING MOTHERS It is not known whtther this drug s wented h humanmix. H ust of tha drug is daamtd essential. B* patient should stop nursingAOVERtt REACnOJO: Most advtrst Kfects htv*been mid and transient.Inlong-term controltd drica} stucBes. equal to or greatar than 5% cumutntve

lethargy, tiredness, or nutalse, musclt uamps or spasm, or numbness olttt eitianHies, nenntsness, tension, anxiety. ^ititlAif, or tpHilffm md

vtrugo, Insomnia, dtprtssion, bhtrred vtsion, constipation, oausea. wratt-Ing, olamita, gasQic irntation, jrhvuii*^f i pain or cramps, anorena, ortho~ttttic hwoasnsion, premiture ventricular contracbons, irregular htaii b d ,paipttitions. treputneyot urinatun. nocturti, polyurta, rash, nhivs, pruritus,vMCuttis. ImpoConct or reduced ibido. rhinorrhea, kshlng.nypenjncemla,hyperplyccmia. hyporafinnb, hypochloremia. incrcast In seruni urea nMn>-geo (BIM) or crcatfnfcit, gfycosuria. wvght too, dry moufli. tnglng olexti amities Ctnical hypoiilcmii occurred in 3% and 7% rt patitnti gntnindapamide 2 Jb mg md 5 0 mg. rtspecttttty

HOW UPnSEt. Wbtte. nxn) tim-coCad aUets ol 2.5 u^ r botfin of100. 1.000. md in und-dose bister packs, boxes of 100 (10 x 10 strips)REFERENCES: 1. Ames RP: The tfrects o) autltyuwtenth* flruos on strumftptts aod ipuuiulaiB I Ouratia Owgx }9&,32:2&>m 2 Tht UpidRestarch CMcs Coronary Primary Prewrtion TroJ ResufirD Thtrttition-shf) ol rrtuciiw In ixidtnca ol coronary heart ft*tWH to chottsttrol bwr-ra iUM 19B4.S1 385-374 J, Scatrino A. 6 *on» f, Quntot F, a it

CMM.I I IfMslioitJon on lono-ttrni ifticts of tndjpumdt to p m m wtbmantU l u f i c i m i CurltrrRa US4.35 17-22 < Bebq S. VUmt i iRA. W t a ES. a A L o u - e m evericra «ttx fampimtt Am mm J1S63.106 2SJ-262

S a prodna d m t o to U [reaming aawacn

Product ol Servier Research liauiuU

RORER PHARMACEUTICALSI •OwWond1 nORSI PHAR1UCEUTIU1. CORPORATION1 roRTVW5HMOTON.PAt9IIW

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We're givingheart disease a

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THE AMERICANHEART ASSOCIATION

PHARMACEUTICALROUNDTABLE

Some of the biggest names inmedicine have joined forceswith us in the fight against acommon enemy — heartdisease They've teamed upto form the AHA Pharma-ceutical Roundtable, a groupcommitted to funding car-diovascular research proj-ects that have beenapproved as promising, butthat could not be fundedbecause we lacked theresources.

It's our pleasure to intro-duce the members of thisselect new circleFOUNDING MEMBERSBristol-Myers CompanyCIBA-GEIGY

Corporation

Genentech, Inc.Sandoz Pharmaceuticals

CorporationSquibb CorporationWyeth-Ayerst

LaboratoriesWlnthrop

Pharmaceuticals/Division of SterlingDrugs, Inc.

REGULAR MEMBERBoehringer Ingelheim

Pharmaceuticals, Inc.

We ask you to join us inrecognizing these com-panies for the importantcommitment they

represent

The AHA Pharmaceu-tical Roundtable: Itspowerful medicine.

American HeartAssociation

WERE FIGHTING FORMDUR UFE

Meetings Calendar

Meetings Calendar1988

Indicates meetings sponsored by the scientificcouncils of the American Heart Association.

Nov 17-18: Annual Kinetic Workshop. Wilson Hall,National Institutes of Health, Bethesda, Md.Sponsored by the National Cancer Institute.Inquiries: Dr Loren Zech, Bldg 10, Room 7N117,NIH, Bethesda, MD 20892, tel 301-496-8914; orDr Barbara Howard, Medlantic Research Foun-dation, 108 Irving St NW, Washington, DC20010, Tel 202-877-6536.

Nov 30-Dec 1: Frontiers in Basic Sciences That Relate toHeart, Lung, and Blood Diseases Symposium.Genetic Basis of Human Disease: Molecular Mech-anisms and Strategies for Therapy. Masur Audi-torium, National Institutes of Health, Bethesda,Md. Sponsored by the NHLBI. Doctors RonaldG. Crystal and Arthur W. Nienhuis, cochair-men. Inquiries: Dr Elliott C. Kulakowski, Officeof Program Planning and Evaluation, NHLBI/NIH, Bldg 31, Room 5A06, Bethesda, MD 20892.Tel 301-496-6765.

Dec 2-3: Iipoprotein<a): 25 Years of Progress. The Knick-erbocker Hotel, Chicago. Sponsored by the Uni-versity of Chicago School of Medicine. Angelo M.Scanu, MD, program director. Inquiries: Centerfor Continuing Medical Education, 5841 Mary-land, Chicago, IL 60637. Tel 312-702-1056.

Dec 5-7: Neurosurgery NYC/1988. Grand Hyatt Hotel,New York City. Sponsored by New York Uni-versity Medical Center Postgraduate MedicalSchool. Inquiries: NYU Medical Center Post-graduate Medical School, 550 First Ave, NewYork, NY 10016. Tel 212-340-5295.

Dec 12-17: CT and MRI—Head to Toe. Grand HyattHotel, New York City. Sponsored by New YorkUniversity Medical Center Postgraduate Medi-cal School. Inquiries: NYU Medical Center Post-graduate Medical School, 550 First Ave, NewYork, NY 10016. Tel 212-340-5295.

Dec 27-30: Clinical Cardiology 1988: Current and FutureTrends hi Diagnosis and Management. ThirdAnnual Symposium. Marriott World Center,Orlando, Fla. Sponsored by University of Wis-consin Medical School and Mount Sinai MedicalCenter, Milwaukee. Jeremy N. Ruskin, MD,and Masood Akhtar, MD, course directors.Inquiries: Masood Akhtar, MD, Sinai-SamaritanMedical Center, 950 N 12th St, Milwaukee, WI53233. Tel 414-289-8132.

1989Jan 7-11: Scientific Conference on Membrane Events and

IntraceUular Signalling in the Cardiovascular Sys-tem. Waikoloa, Hawaii. Sponsored by the Amer-ican Heart Association, Council on Basic Scienceand the Japan Heart Foundation. Attendancelimited. Inquiries: American Heart Association,

Scientific Sessions, 7320 Greenville Ave, Dallas,TX 75231. Tel 214-706-1253.

Feb 6-10: Courses in Diagnostic Ultrasound: Echocardtog-raphy. Winston-Salem, NC. Inquiries: Registrar,Ultrasound Center, Bowman Gray School of Med-icine, Winston-Salem, NC. Tel 919-748-4505.

Feb 9-11: 14th International Joint Conference on Strokeand Cerebral Circulation. San Antonio, Tex.Sponsored by the American Heart Association,Stroke Council. Inquiries: American Heart Asso-ciation, Scientific Sessions, 7320 Greenville Ave,Dallas, TX 75231. Tel 214-706-1453.

Feb 10-15: Laser and Stent Therapy in Vascular Disease:International Congress II. The Phoenician Resort,Scottsdale, Ariz. Sponsored by the Arizona HeartInstitute and Foundation in conjunction with theAmerican College of Angiology and the Cardio-vascular Center of Excellence at Humana Hos-pital, Phoenix. Inquiries: Paula Jennings, POBox 10000, Phoenix, AZ 85064. Tel 602-955-1000, ext 623.

Feb 11-13: Third International Symposium on Intra-cranial Hemodynamks: Transcranial Doppler andCerebral Blood Flow. Hyatt Regency Hotel, SanAntonio, Tex. Merrill P. Spencer, MD, organiz-ing committee chairman. Inquiries: Marian Man-del, Symposium Coordinator, Institute of AppliedPhysiology and Medicine, 701 16th Ave, Seattle,WA 98122. Tel 206-442-7330.

Feb 11-18: Cardiopubnonary Emergencies. Snowbird(Utah) Resort. Sponsored by Scripps MemorialHospital and the American Institute of Postgrad-uate Education. Inquiries: Edith S. Bookstein,AIPE, PO Box 2586, La Jolla, CA 92038. Tel619-454-3212.

Feb 16-19: Pathophysiology and Techniques of Cardio-pulmonary Bypass: EX. Ninth Annual San DiegoCardiothoracic Surgery Symposium. San DiegoMarriott Hotel and Marina. Sponsored by theCardiothoracic Research and Education Foun-dation. Joe R. Utley, MD, program director.Inquiries: CREF, PO Box 33185, San Diego, CA92103. Tel 619-692-9115.

Feb 22-25: Scientific Conference on Coronary Atheroscle-rosis and Thrombosis. Keystone, Colo. Sponsoredby the American Heart Association, Councils onCirculation, Arteriosclerosis, Thrombosis, and Clin-ical Cardiology. Inquiries: American Heart Asso-ciation, Scientific Sessions, 7320 Greenville Ave,Dallas, TX 75231. Tel 214-706-1253.

March 1-4: 21st Teaching Conference In Clinical Cardi-ology. Bal Harbor, Fla. Sponsored by the Uni-versity of Miami School of Medicine. Cospon-

^ ^ ™ sored by the American Heart Association,Council on Clinical Cardiology. Inquiries: Amer-ican Heart Association, Scientific Sessions, 7320Greenville Ave, Dallas, TX 75231.

March 6^8: International Research Symposium: Diabe-tes, Lipoproteins, and Atherosclerosis. HyattRegency Hotel, Hilton Head, SC. Abstracts byNov 18, 1988. Inquiries: American DiabetesAssociation, 1989 Research Symposium, 1660

29

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COLUMBUS INSTRUMENTS

P.O. BOX 44049COLUMBUS, OHIO 43204-0049, USAPHONE (614) 488-6176 TELEX 246514

ASSISTANTPROFESSOR

A position for Assistant Professor in theDepartment of Medicine at Boston Univer-sity School of Medicine is available. The ap-plicant will be expected to teach pre- andpost-doctoral research fellows and to initi-ate independent research in the generalarea of cardiovascular research. M.D. orequivalent, at least one year of laboratoryresearch experience and generalknowledge of experimental hypertensionand atherosclerosis is required. Technicalexpertise in RNA isolation, Northern blot-ting techniques, and in situ hybridizationis desirable.Address correspondence to: Dr. PeterBrecher, Cardiovascular Institute, BostonUniversity School of Medicine, RoomL-219, 80 East Concord St., Boston, MA02118-2394.

An affirmative action/equal opportunity employer

Boston UniversityMedical Campus

STATEMENT OF OWNERSHIP. M

HYPERTENSION

MANAQENENT AND CIRCULATION

MONTHLY

American Heart A s s o c i a t i o n , 7320 Gre e n v i l l e Avenu

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0 1 9

12

e, Dallas

American Heart A s s o c i a t i o n , 7320 Qre e n v i l l e Avenu

Edgar Haber, K.D. 55 F r u i t S t ree tBoston. MA 02114

Nancy PMnney 7 W h i t t i e r P lace , S u i t eBoston, HA 02114-1408

American Heart A s s o c i a t i o n 7321

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CirculationMonograph

Cardiovascular Surgery 1986Part 2

Donald B. Doty (etf)

"Cardiovascular Surgery 1986, Part 2," the second in a two-part series supple-ment to Circulation, consists of papers presented by the Council on Cardiovas-cular Surgery at the American Heart Association's 59th Annual ScientificSessions. Problems in heart surgery, such as the mechanism of myocardialreperfusion injury in neonates and the results of surgery for hypertrophicobstructive cardiomyopathy, are discussed. Other topics offered include cardiactransplantation in children and adolescents, the role of intraoperative high-frequency epicardial echocardiography during coronary artery revascularization,and noninvasive detection of human cardiac transplant rejection with indium-111antimyosin (Fab) imaging. Supplement to Circulation, November 1987. CirculationMonograph No. 10, soft cover, 185 pp. ISSN 0009-7322 ISBN 0-87493-259-9.

Order No. 73-1161 $UA0

To order use this coupon:

• Check enclosed (Make payable to the American Heart Association)

Send me copies of CardlmascalarSurgery 1988, Part2 (73-1161) at $14.40 each. Price includespostage and handling.

JUI orders most to prepaid.

Olr SUte Up or Post* Coda

Mail to: ^ A m e r i c a n Heart AssociationNational Center7320 Greenville /VenueDallas, Texas 75231

thjpvvivnsiim November 1988, Volume 12, Number 5

Advertisers' IndexBoston University 30Columbus Instruments 30Gould 23Journal of Hypertension 31Marion Laboratories 21, 22Pfizer Laboratories 8 - 10, Cover 3, Cover 4Rorer Pharmaceuticals Cover 2 , 1 , 2Searle, Inc 1 7 - 1 8Sun tech Medical Instruments 15

Vicki SullivanScientific Publishing

Director

Jacqueline LaferAdvertising Production

Manager

American Heart Association, 7320 Greenville Avenue, Dallas, Texas 75231

Advertising SalesPharmaceutical Media Inc.

130 Madison Ave.New York, NY 10016

(212) 685-5010

All possible care is taken in preparing this index. AHA is not responsible for errors or omissions.

Journal of HypertensionOfficial Journal of the International Society of Hypertension

Volume 6 Number 9 September 1988

Prospective review685 The link between cytosolic Ca2+ and the Na+H+ antiport a unifying factor for essential hypertension

Abraham Aviv

Rapid communication693 The BBB study: a prospective randomized study of intensified antihypertensive treatment

The BBB study group

Original papers699 Cardiovascular baroreceptor control during angiotensin-induced acute hypertension in the dog

Roger J. Bagshaw and Robert H Cox

711 Sympathetic predominance in essential hypertension a study employing spectral analysis of heart rate variabilityStefano Guzzetti, Emanuela Piccaluga, rodolfo Casati, Sergio Cerutti, Federico Lombardi, Massimo Pagani andAlberto Malliani

717 Renal and systemic vascular conductances in renal wrap hypertension in rabbitsMasanobu Takata, Kate M. Denton and Warwick P Anderson

723 Pressure natriuresis and control of arterial pressure during chronic norepinephrme infusionJohn E. Hall, H Leland Mizelle, Lori L. Woods and Jean-Pierre Montani

733 The effects of coarctation hypertension upon vascular inositol phosphohpid hydrolysis in Wistar RatsJeremy D. Ollerenshaw, Anthony M. Heagerty, Kevin P West and John D. Swales

739 Suppression of hypertension during chronic reduction of brain acetylcholme in spontaneously hypertensive ratsHugo M. Vargas and Henry E. Brezenoff

747 Hormone, calcium and blood pressure relationships in primary hyperparathyroidismA. Mark Richards, Enc A. Espiner, M. Gary Nicholls, Hamid Ikram, Eric J Hamilton and Andrew H. Maslowski

753 Repeated measurements of ambulatory blood pressureLawrence F. Van Egeren

757 Physiological increases in circulating noradrenaline are antinatnuretic in manJohn J. McMurray, Peter H. Seidelin, David J.K. Balfour and Allan D Struthers

Current world literatureH31 Bibliography of the current world literature in hypertension

Meetings

Orders should be sent to Gower Academic Journals Ltd,34 Cleveland Street, London W1P 5FB, UK. (fc

Meetings Calendar

Duke St, Alexandria, VA 22314. Tel 1-800-ADA-DISC.

March 8-10: 90th Annual Meeting of the AmericanSociety for Clinical Pharmacology and Therapeu-tics. Opryland Hotel, Nashville. Doctors D. CraigBrater and Sandy Shepherd, scientific programdirectors. Inquiries: Ms Elaine Galasso, 1718Gallagher Rd, Norristown, PA 19401-2800. Tel215-825-3838.

March 9-12: 24th Annual Meeting of the AmericanSociety of Contemporary Medicine and Surgery.The Diplomat Hotel, Hollywood, Ha. Inquiries:John G. Bellows, MD, PhD, 233 East Erie St,Suite 710, Chicago, IL 60611. Tel 312-951-1400.

March 17: Fourth Annual Research Utilization Confer-ence: Promotion of Health/Prevention of Illness.Tucson. Sponsored by University Medical Cen-ter, Tucson, and University of Arizona Collegeof Nursing. Inquiries: Carolyn Murdaugh, PhD,RN, Nursing Administration, University Medi-cal Center, 1501 N Campbell, Tucson, AZ 85724.

March 19-23: 38th Annual Scientific Session of theAmerican College of Cardiology. Anaheim, Calif.Inquiries: Meetings Services Department, Amer-ican College of Cardiology, 9111 Old George-town Rd, Bethesda, MD 20814. Tel 1-800-253-4636; in Maryland or outside US, call301-897-5400.

April 10-17: Molecular Biology of the CardiovascularSystem. Keystone, Colo. Organized by DoctorsRobert Roberts and Joseph Sambrook. Cospon-sored by the University of California at LosAngeles. Abstracts by Dec 29, 1988. Inquiries:UCLA Symposia, 2032 Armacost Ave, LosAngeles, CA 90025. Tel 213-207-5042. Telex3716012. Fax 213-207-2397.

April 12-16: Third Annual Review and Update: CriticalCare Medicine Course. Crowne Plaza Hotel,Rockville, Md. Sponsored by the Clinical Cen-ter, National Institutes of Health. Doctors JosephParrillo and Henry Masur, cochairmen. Inqui-ries: Svetlana Lisanti, Center for BiomedicalCommunication, 491 Grand Ave, Englewood,NJ 07631. Tel 201-385-1808.

April 13-15: National Student Research Forum. TheUniversity of Texas Medical Branch, Galveston,Tex. Sponsored by the American Medical Asso-ciation and American Academy of Family Phy-sicians. Inquiries: National Student ResearchForum, Room 209, Family Medicine Bldg, RouteH-56, The University of Texas Medical Branch,Galveston, TX 77550. Tel 409-761-3762.

April 13-16: Prevention 89: State of the Art. Atlanta.Inquiries: Prevention 89,1030 15th St NW, Suite410, Washington, DC 20005. Tel 202-789-2928.

May 1-3: First International Symposium on EndotheUum-Derived Vasoactive Factors. Philadelphia. Inqui-ries: Dr Gabor M. Rubanyi, Berlex Laborato-ries, Inc, Department of Pharmacology, 110East Hanover Ave, Cedar Knolls, NJ 07927.

May 4-6: Embryonic Origins of Defective Heart Devel-opment Key Bridge Marriott, Alexandria, Va.

Sponsored by the New York Academy of Sci-ences. Dale E. Bockman, PhD, and Margaret L.Kirby, PhD, conference chairmen. Posterabstracts by Jan 1, 1989, to Dr Dale E. Bock-man, Department of Anatomy, Medical Collegeof Georgia, Augusta, GA 30912-3305. Inquiries:Conference Department, The New York Acad-emy of Sciences, 2 East 63rd St, New York, NY10021. Tel 212-838-0230.

May 6-9: National Conference on High Blood PressureControl: Advances hi Hypertension Control inSpecial Populations. Hilton at Walt Disney WorldVillage, Lake Buena Vista, Fla. Inquiries:National Conference on High Blood PressureControl, 1733 Bethesda Ave, Suite 530, Bethesda,MD 20814. Tel 301-951-3275.

May 13-17: Eighth Scientific Meeting of the Inter-American Society of Hypertension. San Juan,Puerto Rico. Inquiries: Planning Committee ofthe Inter-American Society of Hypertension, c/oSociedad de Nefrologia de P.R., Inc, PO Box11428, Ave Fernandez Juncos Station, Santurce,PR 00910. Tel 809-758-6900 or 763-3139.

May 14-18:13th Congress of the International Society forHeart Research in Conjunction With ISHR-American Section Meeting: Pharmacologic Mech-anisms and Heart Disease. University of Michi-gan, Ann Arbor. Benedict R. Lucchesi, PhD,MD, chairman. Inquiries: Glenda Radine, Uni-versity of Michigan Extension Service, Depart-ment of Conferences and Institutes, 200 Hill St,Ann Arbor, MI 48104-3297. Tel 313-764-5304.

May 15-19: Courses hi Diagnostic Ultrasound: EchocardJ-ography. Winston- Salem, NC. Inquiries: Regis-trar, Ultrasound Center, Bowman Gray School ofMedicine, Winston-Salem, NC. Tel 919-748-4505.

May 24-27: 23rd Annual Hugh Lofland Conference onArterial Wall Metabolism. Rippling River Resort,Welches, Ore. Inquiries: M.R. Malinow, MD,Chairman, Hugh Lofland Conference, OregonRegional Primate Research Center, 505 NW 185thAve, Beaverton, OR 97006. Tel 503-690-5258.

June 18-22: Second International Conference on Preven-tive Cardiology and Annual Meeting of the Amer-ican Heart Association's Council on Epidemiol-ogy. Washington (DC) Hilton Hotel. Sponsoredby the American Heart Association, Council onEpidemiology, in cooperation with the Interna-tional Society and Federation of Cardiology,Council on Epidemiology; American College ofCardiology; National Heart, Lung, and BloodInstitute; and World Health Organization.Abstracts by Dec 15, 1988. Official language:English. Inquiries: Secretariat, Second Interna-tional Conference on Preventive Cardiology,9650 Rockville Pike, Bethesda, MD 20814.

July 30-Aug 12: 15th 10-Day Seminar on Epidemiologyand Prevention of Cardiovascular Diseases. LakeTahoe, Calif. Sponsored by the American HeartAssociation, Council on Epidemiology. Inqui-ries: American Heart Association, Scientific Ses-

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Meetings Calendar

Sept

Sept

Nov 7

Nov

Nov

sions, 7320 Greenville Ave, Dallas, TX 75231.Tel 214-706-1438.

24-29: Board Review Coarse In CardiovascularDisease. Philadelphia. Sponsored by the Phila-delphia Heart Institute and cosponsored by theAmerican Heart Association, Council on Clini-cal Cardiology. Inquiries: Cardiology BoardReview Course, Philadelphia Heart Institute,39th and Market Streets, Philadelphia, PA 19104.Tel 215-662-9222.

26-29: 43rd Annual Fall Conference and ScientificSessions of the Council for High Blood PressureResearch. Cleveland. Sponsored by the Ameri-can Heart Association, Council for High BloodPressure Research. Inquiries: American HeartAssociation, Scientific Sessions, 7320 GreenvilleAve, Dallas, TX 75231. Tel 214-706-1253.1989 Subspecialty Examination in Critical Care

Medicine. Registration: Jan 1-April 1, 1989.Inquiries: Registration Section, American Boardof Internal Medicine, 3624 Market St, Philadel-phia, PA 19104.

7-8: 1989 Subspecialty Examination in Cardiovas-cular Disease. Registration: Jan 1-April 1, 1989.Inquiries: Registration Section, American Boardof Internal Medicine, 3624 Market St, Philadel-phia, PA 19104.

8-11: Tenth International Symposium on DrugsAffecting Lipid Metabolism. Westin GalleriaHotel, Houston. Sponsored by the FondazioneGiovanni Lorenzini; Giovanni Lorenzini Medi-cal Foundation; Institute of Pharmacological Sci-ences of the University of Milan (Italy); Meth-odist Hospital, Houston; and Baylor College ofMedicine, Houston. Doctors Rodolpho Paolettiand Antonio M. Gotto Jr, symposium chairmen.Inquiries: Louis Smith, PhD, c/o InternationalMeeting Managers, Inc, 4550 Post Oak Place,Suite 248, Houston, TX 77027. Tel 713-965-0566.Telex 205734 IMMI UR. Fax 713-978-6329.

13-16: 62nd Scientific Sessions of the AmericanHeart Association. New Orleans. Inquiries: Amer-ican Heart Association, Scientific Sessions, 7320Greenville Ave, Dallas, TX 75231.

Abroad1988Nov 27-30: Second International Conference on Trans-

cranial Doppler Sonography. Salzburg, Austria.Sponsored by the Salzburg State Governmentand the Christian Doppler Institute for MedicalScience and Technology. Inquiries: Second Inter-national Conference on Transcranial DopplerSonography, Christian Doppler Institute, Depart-ment of Neurology, Landesnervenklinik, Ignaz-Harrer-Strasse 79, A-5020 Salzburg, Austria.

Nov 29-Dec 2: Third International Kawasaki DiseaseSymposium. Keidanren Kaikan, Tokyo. Spon-sored by the American Heart Association, Coun-cil on Cardiovascular Disease in the Young;

Nov

Japan Heart Foundation; and Japan KawasakiDisease Research Society. Official languages:English and Japanese, with simultaneous trans-lation. Inquiries: Japan Heart Foundation, 603,Maru-Bldg, 2-4-1, Marunouchi, Chiyoda-ku,Tokyo 100, Japan.

Dec 1-3: International Symposium on TransesophagealEchocardiography. Mainz, Federal Republic ofGermany. Inquiries: Raimund Erbel, MD, II.Medical Clinic, Johannes Gutenberg-UniversityMainz, LangenbeckstrajSe 1, D-6500, Mainz,Federal Republic of Germany. Tel 0-6131/17-2230/17-3999.

Dec 4-8: Third International Symposium on Hyperten-sion in the Community. Tel Aviv (Israel) HiltonHotel. Under the auspices of the InternationalSociety of Hypertension, World HypertensionLeague, Israel Academy of Sciences and Human-ities, and Sackler Faculty of Medicine, Tel AvivUniversity. Official language: English. Inquiries:Secretariat, Third International Symposium onHypertension in the Community, POB 50006,Tel Aviv 61500, Israel. Tel 03-654571. Telex341171 KENSLL.

Dec 5-9: Third International Symposium on Hyperten-sion in the Community. Tel Aviv, Israel. Officiallanguage: English. Inquiries: Secretariat, ThirdInternational Symposium on Hypertension inthe Community, POB 50006, Tel Aviv 61500,Israel. Tel 03-654571. Telex 341171 KENS IL.

Dec 10-11: Third International Symposium on Hyperten-sion In the Community, Tiberias, Israel. Officiallanguage: English. Inquiries: Secretariat, ThirdInternational Symposium on Hypertension inthe Community, POB 50006, Tel Aviv 61500,Israel. Tel 03-654571. Telex 341171 KENS IL.

Dec 15: Potassium Channel Modulators: New Drugs WithNovel Mechanisms of Action. Royal College ofPhysicians, London. Inquiries: Penny Robin-son, IBC Technical Services Ltd, Bath House,56 Holborn Viaduct, London EC1A 2EX,England. Tel 01-236-4080. Telex 888870 IBC G.

1989Jan 19-20: Electrical Stimulation of Musde. Hexham

General Hospital, Northumberland, United King-dom. Sponsored by Biological Engineering Soci-ety. Inquiries: Dr R.J. Minns, Regional MedicalPhysics Department, Durham Unit, DryburnHospital, Durham, United Kingdom. Tel 091-386-4911.

February: How to Approach Complex Arrhythmias. Can-cun, Mexico. Cosponsored by the AmericanHeart Association, Council on Clinical Cardiol-ogy. Inquiries: American Heart Association, Sci-entific Sessions, 7320 Greenville Ave, Dallas,TX 75231.

March 21-24: Ninth International Symposium on Inten-sive Care and Emergency Medicine. BrusselsCongress Center. Sponsored by the EuropeanSociety of Intensive Care, the Society of Critical

33

Meetings Calendar

Care Medicine, and the World Federation ofSocieties of Intensive Care. Abstracts by Dec31, 1988. Official language: English. Inquiries:Dr Jean-Louis Vincent, Department of IntensiveCare, Erasme University Hospital, Route deLennik 808, B-1050 Brussels, Belgium. Tel 32-2-568-33-80. Telex 62-546.

March 29-April 1: Serotonin: From Cell Biology toPharmacology and Therapeutics. An Interna-tional Symposium. Palazzo dei Congressi, Flor-ence, Italy. Sponsored by the Serotonin Cluband the Fondazione Giovanni Lorenzini. Prof R.Paoletti and Dr Paul M. Vanhoutte, cochairmen.Inquiries: Fondazione Giovanni Lorenzini, ViaMontenapoleone 23, 20122 Milan, Italy. Tel02/702267-783868.

April 2-5: Macrophage-Smooth Musde Interactions hiAtherogenesis: Tenth Annual European Confer-ence on Vascular Biology. Queen's College, Cam-bridge, England. Doctors D.E. Bowyer and A.Kadar, organizers. Inquiries: Dr J. Gordon,Research and Development Division, British Bio-technology Ltd, Brook House, Watlington Rd,Cowley Oxford OX4 5LY, United Kingdom.

April 6-8: Second International Assisi Symposium on Heartin Renal Diseases and hi Dialysis. Cittadella, Assisi,Italy. Sponsored by the University of Perugia andthe Italian Society of Nephrology, Cardiology, andHypertension. Inquiries: Dr Mario Timio, Sympo-sium Chairman, Department of Nephrology andDialysis, 06038, Spello-Perugia, Italy. Tel 0742-651109-652755.

April 10-16: Third International Symposium on Cardio-vascular Pharmacotherapy. Montreux, Switzer-land. Inquiries: Adam Schneeweiss, MD, Scien-tific Secretary, 9 Kehilat Sofia St, 69018 TelAviv, Israel.

April 19-21: Workshop: What Are the Initial Lesions hiAtherosclerosis? (Part of the 23rd Scientific Meet-ing of the European Society for Clinical Inves-tigation.) Athens. Dr S. Moncada, FRS, chair-man. Limited attendance. Inquiries: Dr J.F.Martin and Dr R.F.G. Booth, Department ofMedicine, King's College Hospital MedicalSchool, Denmark Hill, London, SE5 8RX, UnitedKingdom. Tel 01-658-2211, ext 5136.

April 20-22: International Atherosclerosis Congress. Hof-burg, Vienna. Organized by the European Ath-erosclerosis Group. Inquiries: Prof Dr G.M.Kostner, Medical Biochemistry, University ofGraz, Harrachgasse 21, A-8010, Graz, Austria.

May 4-6: Tenth Annual Scientific Session of the NorthAmerican Society of Pacing and Ekctrophysiology.Sheraton Centre Hotel and Towers, Toronto, Can-ada. Abstracts by Dec 1, 1988. Abstracts andmanuscripts for Young Investigator Award by Jan5, 1989. Inquiries: NASPE, 13 Eaton Court, Wel-lesley Hills, MA 02181. Tel 617-237-1866.

May 20-21: Transesophageal and Color Doppler. (Pre-cedes International Workshop on PatientDecision-Making in CAD, May 22-24). Bari,Italy. Cosponsored by the University of Bari

and the Thorax Center, Erasmus University,The Netherlands. Inquiries: Organizing Secre-tariat, Inter-Centre, Via Principe Amedeo 93,70122 Bari, Italy. Tel 80-214154.

May 21-25: First International Symposium on HeartFailure: Mechanisms and Management. Jerusa-lem. Abstracts by Nov 30,1988. Inquiries: AsherKimchi, MD, and Basil S. Lewis, MD, Cochair-men, PO Box 50006, Tel Aviv, Israel 61500. Tel03-654571. Telex 341171 KENS IL.

May 22-24: International Workshop on Patient Decision-Making in Coronary Artery Disease: Present Roleand Future Prospectives of Echocardiography.Bari, Italy. Cosponsored by the University ofBari and the Thorax Center, Erasmus Univer-sity, The Netherlands. Abstracts by Dec 15,1988. Inquiries: Organizing Secretariat, Inter-Centre, Via Principe Amedeo 93, 70122 Bari,Italy. Tel 80-214154.

May 25-27: Fourth International Symposium on CalciumAntagonists: Pharmacology and Clinical Research.Congress Palace, Florence, Italy. Abstracts byFeb 10, 1989. Inquiries: Fondazione GiovanniLorenzini, Via Monte Napoleone, 23, 20121Milan, Italy. Tel 02-78-38-68 or 70-22-67. Fax02-781511.

May 28-31: Fourth European Symposium on CardiacPacing. Stockholm. Official language: English.Inquiries: Secretariat, EURO-PACE 1989, c/oKreab Congrex, Box 5619, S-11486 Stockholm,Sweden. Tel +46-8-723-42-30. Telex 16949 Kre-con S.

May 28-June 1: 14th International Symposium on Cere-bral Blood Flow and Metabolism: Brain 89.Palazzo dei Congressi, Bologna, Italy. Spon-sored by the University of Bologna and theUniversity of Rome. Inquiries: Prof Cesare Fies-chi, c/o GIBI Studio Congressi, Via Marco Besso,40 00191 Rome, Italy. Tel 06-3286478-3273291.

June 4-6: Neurotransmlssion and Cerebrovascular Func-tion. (Official satellite of the 14th InternationalSymposium on Cerebral Blood Flow and Metab-olism, May 28-June 1.) La Napoule, FrenchRiviera, France. Inquiries: Dr J. Seylaz, INSERMU 182, CNRS UA 641, 10 avenue de Verdun,75010 Paris, France. Tel 33-1-42-41-79-69.

June 28-July 2: Fourth International InterdisciplinaryConference on Hypertension hi Blacks. KenyataInternational Conference Center, Nairobi,Kenya. Sponsored by the International Societyon Hypertension in Blacks. Abstracts and awardsnominations by Dec 1, 1988. Inquiries: CecileCate, Executive Director, International Societyon Hypertension in Blacks, 69 Butler St SE,Atlanta, GA 30303.

July 9-14: XXXI International Congress of PhysiologicalSciences. Helsinki, Finland. Inquiries: Secretar-iat, XXXI International Congress of Physiolog-ical Sciences, PO Box 722, 00101 Helsinki,Finland. Tel +358-0-177331. Telex 122529 Trexsf. Fax 611188.

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Meetings Calendar

July 23-28: 13th Interamerican Congress of Cardiology.Rio de Janeiro. Sponsored by the InteramericanSociety of Cardiology, the International Societyand Federation of Cardiology, and the BrazilianSociety of Cardiology. Official languages:English, Spanish, and Portuguese. Inquiries: Bra-zilian Society of Cardiology, Av Paula Sousa364, Rio de Janeiro, RJ, Brazil 20271, or MarioF.C. Maranhao, MD, Rotating Secretary of theInteramerican Society of Cardiology, Av Batel,1839, Curitiba, PR, Brazil 80420. Tel 21-2841290(Rio de Janeiro) or 41-2447441 (Curitiba).

Aug 17-18: 25th Anniversary and 54th Meeting of theEuropean Atherosclerosis Society. Linkdping,Sweden. Organized by Anders G. Olsson, MD.Inquiries: Kit Burmeister, Department of Inter-nal Medicine, University Hospital, S-581, 85Linkdping, Sweden.

Sept 3-6: 1989 Annual Scientific Meeting: Engineeringfor Health. Bristol, England. Inquiries: The Bio-logical Engineering Society, Royal College ofSurgeons, Lincoln's Inn Fields, London, EnglandWC2A 3PN.

Sept 7-9: 10th European Meeting of the InternationalSociety of Heart Research. Rotterdam, The Neth-erlands. Inquiries: Erasmus University Rotter-dam, Office for Postgraduate Medical Educa-tion, PO Box 1738, 3000 DR Rotterdam, TheNetherlands. Tel 010-4635048/5013. Telex 25076mbrt nl.

Sept 7-9: Electrocardiography: Past and Future. HyattBeach Regency, Nice, France. Sponsored bythe New York Academy of Sciences and theEuropean Congress of Cardiology. Oscar Gar-fein, MD, and Philippe Coumel, MD, conferencechairmen. Inquiries: Conference Department,New York Academy of Sciences, 2 East 63rd St,New York, NY 10021. 212-838-0230.

Sept 19-21: International Symposium on PercutaneousBalloon Valvuloplasty. Fuzhou, People's Repub-lic of China. Abstracts by April 15, 1989. Inqui-ries: ISPBV, Union Hospital, 11 Xingquan Rd,

Fuahou/Fujian, People's Republic of China. Tel591-5578%. Cable 8906/Fuzhou.

October: Third Cardiovascular Pharmacotherapy Inter-national Symposium. Kyoto, Japan. Sponsoredby the International Society of CardiovascularPharmacotherapy. Cosponsored by the Ameri-can Heart Association, Council on Clinical Car-diology. Inquiries: American Heart Association,Scientific Sessions, 7320 Greenville Ave, Dallas,TX 75231.

Oct 15-19: First International Stroke Congress. MiyakoHotel, Kyoto, Japan. Cosponsored by the Japa-nese Cerebrovascular Disease Society and theJapan Heart Foundation. Inquiries: Secretariat,First International Stroke Congress, c/o JapanConvention Services, Inc, Nippon Press CenterBldg, 2- 2-1, Uchisaiwai-cho Chiyoda-ku, Tokyo100, Japan. Tel 03-508-1213. Telex 222-9025JCS J. Fax 03-508-0820.

Oct 17-22: 18th International Epilepsy Congress. NewDelhi, India. Inquiries: Prof M.C. Maheshwari,Secretary-General, 18th International EpilepsyCongress 89, Department of Neurology, Neuro-sciences Centre, All India Institute of MedicalSciences, New Delhi-110029, India.

November: Third World Congress of Pediatric Cardiol-ogy. Bangkok, Thailand. Sponsors include the

^ ^ ^ American College of Cardiology, the American^ ^ ™ Heart Association, the Interamerican Society of

Cardiology, and the International Society andFederation of Cardiology. Official language:English. Inquiries: The Cardiac Children's Foun-dation of Thailand, Children's Hospital, Cardi-ology Unit, Fourth Floor, Rajvithee Rd, Bang-kok 10400, Thailand. Tel 245-7870, 233-5955.Telex 72509 TATBKK.

Dec 3-12: International Roundtable on Silent MyocardialIschemia. Tel Aviv, Israel. Cosponsored by theAmerican Heart Association, Council on Clini-cal Cardiology. Jan J. Kellerman, MD, andEugene Braunwald, MD, cochairmen. Inquiries:Prof Jan J. Kellerman, Institute of Cardiac Reha-bilitation, Chaim Sheba Medical Center, TelHashomer 52621, Israel.

American Heart AssociationScientific Sessions

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Washington, DCNew OrleansDallasAnaheim, CaliforniaNew Orleans

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The American Heart Association welcomesnews and meeting announcements of interest tophysicians, researchers, and others concerned withcardiovascular and cerebrovascular medicine. Allcopy is reviewed by the Office of Scientific Affairsand may be edited for style, clarity, and length.Copy is due 90 days prior to date of publication andshould be addressed to Sarah Flaherty, Editor,News From the American Heart Association, 7320Greenville Avenue, Dallas, TX 75231.

35

o ,

NEWmm REVISEDFOURTH EUTION

Published by DavidMcKay Company, Iand available atlocal bookstores

Money can't buy it. But a changed life-style can go along way toward a healthier future.

Smart living includes eating right—the kinds ofdelicious, low-fat, low-cholesterol foods contained inthe American Heart Association Cookbook. It'sdesigned to help health-conscious people preparefoods that will help them maintain a reasonableweight, reduce the amount of fat and cholesterol in thediet, and cut salt intake.

In this fourth edition of the AHA Cookbook, you'll findthe latest scientific evidence on the relationship be-tween diet and heart health. You'll also find:

• Dietary guidelines for children—how you can startthem off right with low-fat, low-cholesterol foodsand still satisfy the needs of the "fast food"generation.

• A complete guide to restaurant dining• A totally revised fat and cholesterol chart outlining

the fat content of common foods• Expanded information on the basics of microwave

cookery

For a blend of good taste and good health, recom-mend the American Heart Association Cookbook toyour patients.

American Heart Association