{

AIDSPrepared By : Ahmadullah Sial Niazi and Sadullah Nihal Niazi

GHALIB UNIVERSTIYKABUL

AFGHANISTAN

Introduction Epidemiology Etiology Structure of HIV Life Cycle of HIV Clinical Features

Contents :

AIDS : Acquired Immunodeficiency Syndrome HIV : Human Immunodeficiency Virus

Retroviral disease caused by HIV

Depletion of CD4+ T lymphocyte

Opportunistic infection and neoplasms

Introduction :

African green monkey (SIV) , Sootey mangabey (HIV-2) , Chimpanzee (HIV-1)

Sexual Transmission - Homosexual - Heterosexual

Parenteral Transmission - Intravenous drug abusers - Hemophiliacs - Blood transfusion

Epidemiology

Mother-to-Infant Transmission - During Pregnancy - During Delivery - Breast Feeding

HIV can’t be transmitted through:1- Air2-personal contact3-insect bites4-saliva 5-tears

AIDS is caused by HIV belonging to Lentivirus family.

HIV-1 HIV-2

Etiology :

Structure of HIV virus

Life cycle of HIV

Virus-induced self destruction

Targeting by the body own immune system cells

How are CD4 T-cells depleted?

Acute Phase - 50-70% affected people - 3-6 weeks - Sore throat, Myalgia, skin rash, Fever ,Aseptic meningitis

Clinical Features :

Chronic Phase - may last for several years - patient often asymptomatic or often (Lymphadenopathy , (candida) , herpes zoster)

Clinical Features :

Crisis Phase - breakdown of host defenses , Viremia and clinical diseases - Fever (30 + days), fatigue, weight loss and diarrhea - CD4 cells less than 500 cells /

Clinical Features :

Antiretroviral Therapy

Acupuncture

Treatment :

AIDS caused by HIV which kills CD4 T-cells.

Transmission (sexual , blood , mother to infant)

HIV penetrate in CD4 T-cells and replicates

CD4 cells killed directly or killed by body immune sys

Three stages of AIDS : 1-Acute 2-Chronic 3-Crisis

Summary :

THANKS!!!