AGING AGING & & CANCERCANCER

telomareSTOP CYCLE/AGINGSTOP CYCLE/AGING

CANCERCANCER

Proteasome

DNA Repair

Gene loss

ENVIRONMENTAL ENVIRONMENTAL

STRESSSTRESS

mutation

silencing and expressing gene

Oxidative damage

Proteosomal

degradation

Oxidative damage

Proteosomal

degradation

Oxidized and

cross-linked

proteins

Oxidized and

cross-linked

proteins

(Lipofuscin)

Young and clean Old and Dirty

“Garbage

catastrophe”

Anti-aging Reversing the catastrophe

Aging as a catabolic malfunction

and

“Garbage Catastrophe”

telomareSTOP CYCLE/AGINGSTOP CYCLE/AGING

CANCERCANCER

Proteasome

DNA Repair

Gene loss

ENVIRONMENTAL ENVIRONMENTAL

STRESSSTRESS

mutation

silencing and expressing gene

ENVIRONMENTAL FACTORENVIRONMENTAL FACTOR

Nutrition excess calories cancers of colon, rectum, stomach,

breast, ovaries excess fat consumtion obesity

cigaretes 1/3 of cancer deaths Cancers of lung, pancreas, mouth,

larynx, liver, alchohol esophagus and bladder

occupation 5% of cancerdeaths cancers of lung, bladder, stomach, blood, liver, bones, skin

Radiation 3% /xray, uv, isotop blood and skin

Other drug, virus, bacteri various

Cancer cells

Normal and Cancer cells contrast in their proliferation capacity

Normal cells

Limited number of divisions

Permanent growth arrest/senescence

Unlimited number of divisions

Tumor

Vs

CANCER NEED MORE ENERGYCANCER NEED MORE ENERGY

environmental stressenvironmental stress

p53, HSF

ApoptosisApoptosisrepair mechanism,

protecting cell

necroticnecrotic

CancerCancer

healty nutrient/suplement

HSF, HO-1, NOS,

P45OR (GENE

PROTECTOR)

interaction of genes between stressor and food cause cancer