Aging and Chronic Disease RIS Newsletter June 2015

   Carmen  Castaneda-­‐Sceppa,  MD,  PhD  Chair,  c.sceppa@neu.edu    Bahram  H.  Arjmandi,  PhD,  RD  Chair-­‐Elect,  barjmandi@fsu.edu    Christy  C.  Tangney,  PhD,  CNS,  FACN    Past  Chair,  ctangney@rush.edu    Elizabeth  J.  Reverri,  PhD,  RD,  LDN  Secretary,  EJReverri@gmail.com      Katie  P.  Starr,  PhD,  RD,  LDN  Postdoctoral  Representative,  kathryn.starr@duke.edu      Susannah  L.  Gordon,  MS,  RD  Graduate  Student  Representative,  gordon72@purdue.edu     Recap of EB 2015    

Congratulations!  ASN’s  Emerging  Leaders  in  Nutrition  Science  Poster  Competition  featured  eleven  graduate  students  and  four  postdoctoral  fellows  from  the  ACD  RIS.      Congratulations  to  the  winners  who  earned  travel  stipends:    

   

 Graduate  First  Prize:  Kristy  Du  University  of  Illinois    Urbana-­‐Champaign      

 Graduate  Second  Prize:  Jaime  Houdek  Rush  University  Medical  Center      

 Grand  Prize:  Marshall  Miller,  PhD,  USDA-­‐Agricultural  Research  Service

Featured  Speaker    

   Our  annual  business  meeting  featured  Clara  Lau,  PhD,  the  Director  of  Human  Nutrition  Research  at  the  National  Cattlemen’s  Beef  Association  (NCBA),  a  contractor  to  the  Beef  Checkoff  Program.  NCBA  is  the  oldest  and  largest  trade  association  and  marketing  organization  representing  America’s  one  million  cattle  ranchers  and  farmers.  Alongside  the  Executive  Director  of  Nutrition  Research,  Dr.  Lau  assist  in  the  planning,  developing,  managing  and  implementing  of  beef  nutrition  research  programs.  These  programs  are  designed  to  establish,  monitor  and  disseminate  scientific  evidence  on  beef’s  role  in  a  healthy  diet  and  support  the  overall  initiatives  of  the  beef  industry  nutrition  program.        Dr.  Lau  holds  a  bachelor’s  degree  in  Nutrition  Science  from  the  University  of  California,  Davis  and  a  doctorate  in  Human  Nutrition,  Foods  and  Exercise  from  Virginia  Tech.  She  currently  lives  in  the  Washington  DC  area  and  continually  works  towards  maintaining  a  healthy  and  active  lifestyle.        

Thank  you!  Our  late-­‐breaking  symposium  on  the,  “Nutritional  Approaches  for  Osteosarcopenic  Obesity:  Interrelationships  between  Bone,  Muscle,  and  Fat”  was  a  success  with  a  packed  ballroom!  Thank  you  to  our  symposium  speakers:  Jasminka  Ilich-­‐Ernst,  PhD,  RD,  FACN  from  Florida  State  University,  Clifford  Rosen,  PhD  from  Maine  Medical  Center  Research  Institute,  Ronenn  Roubenoff,  MD,  MHS,  FACP,  FACR  from  Novartis  Institutes  for  Biomedical  Research,  and  Wayne  W.  Campbell,  PhD  from  Purdue  University.   Feedback  

We  are  looking  for  feedback  on  our  events  at  EB  2015  in  Boston.  Please  let  us  know  what  you  thought  about  the  1.  new  poster  competition  format  and  2.  business  meeting  and  breakfast,  so  we  can  improve  our  events  for  next  year:  c.sceppa@neu.edu  

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Member Spotlight  

BRUCE  S.  KRISTAL,  PhD  Associate  Professor  of  Neurosurgery,  Department  of  Neurosurgery,  Harvard  Medical  School  in  the  Department  of  Neurosurgery,  Brigham  and  Women’s  Hospital    

   

The  Kristal  laboratory  has  active  projects  in  three  areas:  metabolomics,  lipidomics,  and  proteomics  for  personalized  risk  analysis  based  on  diet  and  obesity,  the  analysis  of  megavariate  data  sets,  and  mitochondrial  roles  in  neurologic  injury.    The  lab  is  testing  whether  blood  tests  based  on  studies  of  food  intake  in  rats  and  humans  can  enable  scientists  to  predict  risk  of  human  disease.  Rats  maintained  on  low  calorie  diets  have  reduced  risk  of  certain  diseases,  such  as  cancer.  This  is  analogous  to  the  reduced  risk  of  diseases  seen  in  humans  who  are  comparatively  lean.      The  lab  and  their  collaborators  have  developed  approaches  to  simultaneously  examine  metabolites  in  

the  blood  using  HPLC  separations  with  Coulometric  electrode  array  detection.    The  use  of  HPLC  coupled  with  high  resolution  mass  spectrometric  (Orbitrap)  approaches  enables  us  to  look  >5,000  lipidomics  features  (e.g.,  >100  structurally  unique  triglycerides).    They  then  use  mathematical  approaches  to  identify  sets  of  these  compounds  that  can  be  used  as  dietary  biomarkers  (giving  information  about  the  diet).    The  goal  is  to  be  able  to  use  blood  tests  developed  in  these  studies  to  predict  long-­‐term  disease  risk  in  individuals  and  use  this  information  for  possible  protective  interventions  and  increased  monitoring.    These  tests  are  expected  to  complement  genetic  testing.    The  Kristal  lab  has  initially  focused  on  chronic  diseases  where  preventative  intervention  and/or  early  diagnostic  screening  are  available  (e.g.,  breast  cancer,  Type  II  diabetes,  hypertension).      

Dr.  Kristal  received  his  BS  in  Life  Sciences  from  MIT  (1986)  and  his  PhD  from  Harvard's  Graduate  School  of  Arts  and  Sciences,  Division  of  Medical  Sciences,  Committee  on  Virology  (1991).    He  was  a  post-­‐doc  (with  Byung  Pal  Yu)  through  Research  Assistant  Professor  at  University  of  Texas  Health  Science  Center  at  San  Antonio  (1991-­‐1996);  he  then  moved  to  Burke  Medical  Research  Institute  (1996)  and  the  Departments  of  Biochemistry/Neuroscience  (1997/1998)  at  Weill  Medical  College  of  Cornell  University  (Associate  Professor,  2004).      He  joined  Brigham  and  Women’s  Hospital/Harvard  Medical  School  (Neurosurgery/Surgery)  in  2007/2008.      He  was  the  founding  secretary  of  the  Metabolomics  Society  (2004-­‐2008)  and  on  their  Board  of  Directors  (2004-­‐2011).      

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RACHEL  A.  MURPHY,  PhD  Assistant  Professor,  Centre  of  Excellence  in  Cancer  Prevention,  School  of  Population  and  Public  Health,  University  of  British  Columbia,  Vancouver,  Canada    

     

Dr.  Murphy  joined  the  Centre  of  Excellence  in  Cancer  Prevention  a  partnership  between  the  Canadian  Cancer  Society  and  the  University  of  British  Columbia  in  2015.    Prior  to  this  Dr.  Murphy  was  employed  at  DSM  Nutritional  Products,  a  leading  supplier  of  vitamins  and  other  nutrients.  She  received  her  PhD  in  Nutrition  and  Metabolism  from  the  University  of  Alberta.  Her  work  characterized  the  clinical  role  of  omega-­‐3  fatty  acids  on  cancer  cachexia  and  response  to  chemotherapy  and  was  recognized  by  the  Canadian  Nutrition  Society’s  PhD  Dissertation  award.  Dr.  Murphy  received  post-­‐doctorate  training  in  epidemiology  at  the  National  Institute  on  Aging  under  Dr.  Tamara  Harris.  Her  post-­‐doctorate  focused  on  understanding  the  role  of  nutrition  and  obesity  on  chronic  disease  risk  in  aging  populations  and  was  supported  by  a  

prestigious  Banting  Fellowship  from  the  Canadian  Institutes  of  Health  Research.  She  was  also  awarded  an  NIH/Office  of  Dietary  Supplements  grant  during  her  fellowship.      The  overarching  goal  of  Dr.  Murphy’s  research  program  is  to  reduce  the  risk  of  chronic  disease  through  modifiable  factors.    Around  one-­‐third  of  cancers  can  be  prevented  by  a  healthy  diet,  healthy  body  weight  and  being  active.  Dr.  Murphy’s  research  focuses  on  optimal  nutrition  and  body  composition  with  an  interest  in  older  adults  and  other  populations  who  have  a  greater  risk  of  cancer  and  chronic  disease.  Additional  research  interests  include  nutrition  throughout  the  disease  continuum  from  diagnosis  to  survivorship  and  novel  markers  of  diet,  obesity  and  metabolism  such  as  metabolomics;  the  study  of  small  molecule  metabolites  in  biological  systems  that  may  help  identify  markers  as  well  as  pathways  linking  risk  factors  and  disease.      Dr.  Murphy  is  active  in  population  research,  public  health  and  community  knowledge  translation.  She  aims  to  translating  her  research  to  health  promotion  strategies  with  the  goal  of  reducing  preventable  cancers  and  chronic  diseases.    She  is  a  member  of  the  American  Society  for  Nutrition  as  well  as  the  Canadian  Nutrition  Society.        

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YANG  PAN,  MD,  PhD  Principal  Scientist,  Global  R&D  Nutrition  Sciences,  PepsiCo    

     

Dr.  Yang  Pan  is  a  Principal  Scientist  of  Global  R&D  Nutrition  Sciences  at  PepsiCo.    In  this  role,  Dr.  Pan  supports  the  Global  Snacks  business  by  driving  the  nutrition  research  and  innovation  programs  on  Better-­‐For-­‐You/Good-­‐For-­‐You  snack  categories  globally,  and  leading  Frito-­‐Lay’s  Health  &  Wellness  outreach  programs  in  US.    Dr.  Pan’s  areas  of  expertise  include  pediatric  and  adult  nutrition,  medical  nutrition,  energy  and  performance,  epidemiology,  cardiometabolic  health,  immunology,  etc.    Dr.  Pan  joined  PepsiCo  in  August  2014.        Prior  to  joining  PepsiCo,  Dr.  Pan  worked  at  The  Coca-­‐Cola  Company  for  7  years  as  Senior  Scientist  of  Global  Scientific  and  Regulatory  Affairs.    In  this  capacity,  Dr.  Pan  served  as  a  Subject  Matter  Expert  and  provided  scientific  and  research  expertise  to  guide  and  support  a  wide  array  of  beverage  business  and  innovation  platforms  globally.    Before  

joining  the  Coca-­‐Cola  Company,  Dr.  Pan  completed  her  research  internship  at  National  Heart,  Lung  and  Blood  Institute  (NHLBI)  of  National  Institutes  of  Health  (NIH)  where  she  conducted  and  published  her  research  on  the  relationship  between  lifestyle  behaviors  (diet  and  physical  activity)  and  metabolic  syndrome  in  U.S.  adolescents.        Dr.  Pan  currently  serves  on  Small  Business  Innovation  Research  (SBIR)  Special  Emphasis  Panel  to  review  phase  I  and  phase  II  research  grants  for  the  Risk,  Prevention  and  Health  Behavior  (RPHB)  Integrated  Review  Group  (IRG)  of  NIH.      She  is  on  the  Dietary  Lipids  Committee  of  International  Life  Sciences  Institute  (ILSI)  North  America.    Dr.  Pan  also  serves  as  ad  hoc  reviewer  for  several  scientific  journals  related  to  nutrition,  epidemiology  and  public  health.    She  is  an  active  member  of  American  Nutrition  Society,  Academy  of  Nutrition  and  Dietetics  and  Institute  of  Food  Technologists.        Dr.  Pan  received  her  doctoral  degree  in  Nutrition  Sciences  from  University  of  Maryland  at  College  Park,  Maryland.    While  pursuing  her  doctoral  degree,  Dr.  Pan  taught  the  core  nutrition  course  and  was  the  two-­‐time  winner  of  Distinguished  Graduate  Teaching  Assistant  Annual  Award  of  University  of  Maryland  (2003  &  2004).    She  was  also  the  two-­‐time  winner  of  the  Annual  Nutrition  Poster  Competition  at  University  of  Maryland  (2005  &  2006).        

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Dr.  Pan  received  her  Medical  Degree  from  Wuhan  University  School  of  Medicine,  Wuhan,  China.    She  completed  her  medical  residency  and  practiced  medicine  at  Wuhan  General  Hospital  of  Guangzhou  Military  Command,  Wuhan,  China.    During  her  medical  training,  she  was  the  winner  of  the  Golden  Prize  of  Medical  Education  Scholarship  for  Outstanding  Academic  Performances  at  Wuhan  University  School  of  Medicine.       Recent ACD RIS Member Publications (Please  send  your  new  and  imminent  citations  to  gordon72@purdue.edu  so  that  we  can  share  these  with  the  entire  membership.) Chondronikola  M,  Annamalai  P,    Chao  T,  Porter  C,  Saraf  MK,  Cesani  F,  and  Sidossis  LS.  A  percutaneous  needle  biopsy  technique  for  sampling  the  supraclavicular  brown  adipose  tissue  depot  of  humans.  Int  J  Obes  (Lond).  2015.    Corcoran  MP,  Nelson  ME,  Sacheck  JM,  Reid  KF,  Kirn  D,  Fielding  RA,  Folta  SC.  Recruitment  of  mobility  limited  older  adults  into  a  facility-­‐led  exercise-­‐nutrition  study:  the  effect  of  social  involvement.  Gerontologist.  2015;  1-­‐8.  doi:  10.1093/geront/gnv018        

Elam  ML,  Johnson  SA,  Hooshmand  S,  Feresin  RG,  Payton  ME,  Gu  J,  Arjmandi  BH.  A  calcium-­‐collagen  chelate  dietary  supplement  attenuates  bone  loss  in  postmenopausal  women  with  osteopenia:  a  randomized  controlled  trial.  J  Med  Food.  2015;18:324-­‐31.  doi:  10.1089/jmf.2014.0100.  Epub  2014  Oct  14.      Hannan  MT,  Mangano  KM,  Sahni  S.  Do  nutrients  influence  bone  health?  A  commentary  on  new  findings  in  the  field.  J  Bone  Miner  Res.  2015;30:967-­‐9.  doi:  10.1002/jbmr.2526.  PMID:  25854707.      Holden  RM,  Booth  SL,  Day  AG,  Clase  CM,  Zimmerman  D,  Moist  L,  Shea  MK,  McCabe  KM,  Jamal  SA,  Tobe  S,  Weinstein  J,  Madhumathi  R,  Adams  MA,  Heyland  DK.  Inhibiting  the  progression  of  arterial  calcification  with  vitamin  k  in  hemodialysis  patients  (ipackhd)  trial:  rationale  and  study  design  for  a  randomized  trial  of  vitamin  k  in  patients  with  end  stage  kidney  disease.  Can  J  Kidney  Health  Dis.  2015;  2:17.    Hooshmand  S,  Kumar  A,  Zhang  Z,  Johnson  SA,  Arjmandi  BH.  Evidence  for  anti-­‐inflammatory  and  antioxidative  properties  of  dried  plum  polyphenols  in  macrophage  RAW  264.7  cells.  Food  Funct.  2015;  13:1719-­‐25.  DOI:  10.1039/C5FO00173K.        

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Hsu  CC,  Cheng  CH,  Hsu  CL,  Lee  WJ,  Huang  SC,  Huang  YC.  Role  of  vitamin  B-­‐6  status  on  antioxidant  defense,  glutathione  and  related  enzyme  activities  in  mice  with  homocysteine-­‐induced  oxidative  stress.  Food  Nutr  Res.  2015;59:25702  doi:  10.3402/fnr.v59.25702      Johnson  SA,  Figueroa  A,  Navaei  N,  Wong  A,  Kalfon  R,  Ormsbee  LT,  Feresin  RG,  Elam  ML,  Hooshmand  S,  Payton  ME,  Arjmandi  BH.  Daily  blueberry  consumption  improves  blood  pressure  and  arterial  stiffness  in  postmenopausal  women  with  pre-­‐  and  stage  1-­‐hypertension:  a  randomized,  double-­‐blind,  placebo-­‐controlled  clinical  trial.  J  Acad  Nutr  Diet.  2015;115:369-­‐77.  doi:  10.1016/j.jand.2014.11.001.  Epub  2015  Jan  8.      K.S.  Kubena.    Metabolic  syndrome  in  adolescents:    role  of  cholesterol  sources,  eggs,  and  others.    In  Watson  RR,  De  Meester  F,  eds.  Handbook  of  eggs  in  human  function.  Human  health  handbooks  no.  9  .  The  Netherlands:  Wageningen  Academic  Publishers,  2015:109-­‐32.        Limdi  NA,  Nolin  TD,  Booth  SL,  Centi  A,  Marques  MB,  Crowley  MR,  Allon  M,  Beasley  TM.  Influence  of  kidney  function  on  risk  of  supratherapeutic  international  normalized  ratio–related  hemorrhage  in  warfarin  users:  a  prospective  cohort  study. Am  J  Kidney  Dis.  2015;65:701-­‐9.  doi:  10.1053/j.ajkd.2014.11.004.  Epub  2014  Nov  25.      

McRorie,  J.  Evidence-­‐based  approach  to  fiber  supplements  and  clinically  meaningful  health  benefits,  part  1:  what  to  look  for  and  how  to  recommend  an  effective  fiber  therapy.  Nutr  Today,  2015;50:82-­‐89.        McRorie,  J.  Evidence-­‐based  approach  to  fiber  supplements  and  clinically  meaningful  health  benefits,  part  2:  what  to  look  for  and  how  to  recommend  an  effective  fiber  therapy.  Nutr  Today.  2015;50:90-­‐97.      Paul  L,  Jacques  PF,  Aviv  A,  Vasan  RS,  D’Agostino  RB,  Levy  D,  Selhub  J.  High  plasma  folate  is  negatively  associated  with  leukocyte  telomere  length  in  Framingham  Offspring  cohort.  Eur  J  Nutr.  2015;54:235-­‐41.  doi:  10.1007/s00394-­‐014-­‐0704-­‐1.  Epub  2014  May  3.    Pop  LC,  Sukumar  D,  Tomaino  K,  Schlussel  Y,  Schneider  SH,  Gordon  CL,  Wang  X,  Shapses  SA.  Moderate  weight  loss  in  obese  and  overweight  men  preserves  bone  quality.  Am  J  Clin  Nutr.  2015;101:659-­‐67.  doi:  10.3945/ajcn.114.088534.    Raiten  DJ,  Ashour  FA,  Ross  AC,  Meydani  SN,  Dawson  HD,  Stephensen  CB,  Brabin  BJ,  Suchdev  PS,  van  Ommen  B,  INSPIRE  Consultative  Group.  Inflammation  and  nutritional  science  for  programs/policies  and  interpretation  of  research  evidence  (INSPIRE).  J  Nutr.  2015;  145:1039S-­‐108S.  doi:  10.3945/jn.114.194571.  Epub  2015  Apr  1.        

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Reidlinger  DP,  Darzi  J,  Hall  WL,  Seed  PT,  Chowienczyk  PJ,  Sanders  TAB.  How  effective  are  current  dietary  guidelines  for  cardiovascular  disease  prevention  in  healthy  middle-­‐aged  and  older  men  and  women?  A  randomized  control  trial.  Am  J  Clin  Nutr.  2015;101:922-­‐30.   Traber  MG,  Leonard  SW,  Bobe  G,  Fu  X,  Saltzman  E,  Grusak  MA,  Booth  SL.  Alpha-­‐tocopherol  disappearance  rates  from  plasma  depend  on  lipid  concentrations:  studies  using  deuterium-­‐labeled  collard  greens  in  younger  and  older  adults.  Am  J  Clin  Nutr.  2015;101:752-­‐9.  doi:  10.3945/ajcn.114.100966.  Epub  2015  Mar  4.    Zingg  JM,  Azzi  A,  Meydani  M.  Induction  of  VEGF  expression  by  alpha-­‐tocopherol  and  alpha-­‐tocopheryl  phosphate  via  PI3Kgamma/PKB  and  hTAP/SEC14L2-­‐mediated  lipid  exchange.  J  Cell  Biochem.  2015;116:398-­‐407.  doi:  10.1002/jcb.24988.  

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